Apparatus, system and method for fluorescence imaging on a planar sensor - Patent Application 20070122997

JP2025532870APending Publication Date: 2025-10-03RGT UNIV OF CALIFORNIA
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Patent Information

Application Number
JP2025518008
Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
Priority Date
2022-09-28
Filing Date
2023-09-26
Publication Date
2025-10-03

AI Technical Summary

Technical Problem

Current laparoscopic fluorescence imagers provide only macroscopic visualization, limiting their application in multi-imaging, while surgical microscopes offer high resolution but are bulky and incompatible with minimally invasive surgical techniques, making it difficult to distinguish microscopic diseased tissue from healthy tissue during surgery.

Method used

A system with an optical front end comprising multiple layers of materials with different refractive indices to form filters and a collimator, integrated with a CMOS sensor, which can be used with surgical tools for high-resolution imaging without lenses, utilizing a fiber optic plate to compensate for angular sensitivity.

Benefits of technology

Enables high-resolution, lens-free imaging that is compatible with minimally invasive surgery, allowing for accurate differentiation between microscopically diseased and healthy tissue during surgery.

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Abstract

Disclosed herein are systems and methods for imaging tissue. Such systems can be used for in vivo or ex vivo imaging. In vivo imaging can include an imager and an optical front end. Such a front end can include a collimator and a filter. This combination can be used to reduce interference or noise from oblique light. Additional systems can be used for laparoscopic imaging and / or image-guided surgery, such as tumor resection.
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