Electrospinning nozzle block equipped with gas ejection means, and electrospinning device equipped with said nozzle block

Abstract

One embodiment of the present invention relates to an electrospinning nozzle block including an internal space for accommodating a spinning solution transferred and injected from a solution storage tank, a nozzle body including a plurality of solution distribution ports, an electrospinning nozzle including an airflow ejection means, a nozzle adapter for detachably connecting the electrospinning nozzle to the nozzle body, and a high voltage application means for applying high voltage electricity from a high voltage generator to the spinning solution accommodated in the internal space of the nozzle body.

Description

[Technical Field]

[0001] This application claims priority based on Korean Patent Application No. 10-2022-0135897, filed on October 20, 2022, the entire contents of which are incorporated herein by reference in their entirety in the specification and drawings thereof.

[0002] The present invention relates to an electrospinning device, and more particularly to a nozzle block for electrospinning having a gas ejection means for forming an air flow layer that surrounds a spun filament discharged from a spinning nozzle at a distance from the discharge port and causes the spun filament to move straight, and an electrospinning device having the nozzle block. [Background technology]

[0003] The electrospinning process is a process of producing nanofibers in an electric field environment by applying a high DC voltage of several thousand to several tens of thousands of volts to a solution and connecting a collector to ground or negative voltage.

[0004] The charged droplets of the spinning solution discharged from the spinning nozzle are formed into a cone shape from the tip of the nozzle, and the cone-shaped protrusion extends longitudinally toward the collecting plate to form a charged filament. The cone-shaped part of the droplet is called a Taylor cone, and the longitudinally extending charged filament is called a jet.

[0005] The jet extending from the protruding part of the Taylor cone undergoes a whipping mode, which oscillates rapidly from a certain point above the critical high voltage, volatilizing the solvent and producing nanofibers with a very small diameter. At this time, the higher the concentration of the spinning solution, the smaller the Taylor cone, the longer the linear jet, and the fewer whipping modes occur.

[0006] When a spinning solution with high surface tension is used, the surface tension of the droplets is greater than the electrical force, making it difficult to convert the conical Taylor cone into a jet of charged filaments. If not all of the charged droplets are converted into charged filaments, some of the discharged solution will collect on the collection plate as fine droplets rather than fibers, resulting in a nanofiber web containing fine droplets, making it difficult to produce a uniform web. For this reason, when using an aqueous solution with high surface tension or a spinning solution with high solution viscosity, spinning is performed by increasing the voltage strength or reducing the discharge rate.

[0007] However, if the voltage strength applied to the spinning solution is increased, the Taylor cone at the end of the nozzle becomes unstable, and the charged filament jet cannot maintain its direction, making it difficult to uniformly accumulate nanofibers in the desired area of ​​the accumulation section.Furthermore, if the discharge rate of the spinning solution is reduced, there is a problem that the productivity of nanofibers decreases.

[0008] Therefore, it is difficult to fundamentally solve the problem of a large amount of fine droplets being contained in the nanofiber web laminated on the collecting plate during the electrospinning process.

[0009] In order to solve the problem caused by the high surface tension of the spinning solution, various methods have been proposed to add auxiliary pressure means such as air or gas to the outside of the spinning filament.

[0010] Patent Document 1 discloses an electrospinning apparatus including a spinning nozzle with multiple needles for spinning nanofibers, and a temperature and humidity unit disposed between the spinning nozzles arranged in multiple rows, which directly injects temperature and humidity-controlled air onto the nanofibers being spun. However, Patent Document 1 only injects temperature and humidity-controlled air onto the nanofiber web accumulated in the collector to prevent temperature and humidity from varying from position to position, and is unable to prevent fine droplets from being generated from the discharged spinning solution.

[0011] Patent Document 2 discloses an electrospinning nozzle module that includes a housing having an outlet hole at one end through which nitrogen gas supplied from the outside is sprayed to the outside, and a nozzle unit having one end inserted into the outlet hole to spray a drug to the outside and the other end supplied with electricity, where the outlet hole is disposed around one end of the nozzle unit, and when the drug is sprayed from one end of the nozzle unit, nitrogen gas is also sprayed around one end of the nozzle unit, thereby spraying and coating the drug onto a target object. The configuration of disposing the nitrogen gas outlet hole around one end of the nozzle unit in Patent Document 2 is intended to prevent the drug from being exposed to general air and becoming infected when spraying and coating the drug.

[0012] Patent Document 3 discloses an electrospinning nozzle pack including a main body having a solution storage space for storing a supplied solution, a plurality of solution injection nozzles provided on the main body along the longitudinal direction so as to communicate with the solution storage space, and gas injection nozzles arranged to surround the solution injection nozzles so as to penetrate the center. Patent Document 3 also has a problem in that the gas injection nozzles are arranged to surround the solution injection nozzles, and the inlet of the injection nozzle is clogged due to solidification of the solution discharged from the solution injection nozzle. [Prior art documents] [Patent documents]

[0013] [Patent Document 1] Korean Patent No. 10-1601169 [Patent Document 2] Korean Patent No. 10-1440448 [Patent Document 3] Korean Patent No. 10-1478184 Summary of the Invention [Problem to be solved by the invention]

[0014] In the above-mentioned conventional techniques, particularly in Patent Documents 2 and 3, a solution injection nozzle, which is a solution ejection outlet, is disposed at the center of a nozzle, and a cap having a central hole larger than the outer diameter of the solution injection nozzle is disposed around the nozzle, and air or gas is ejected from the space formed between the nozzle and the cap to atomize the spinning solution.

[0015] However, such conventional techniques have problems such as solidification occurring at the tip of the solution injection nozzle and directly affecting the air flow of the spinning solution because air or gas is directly injected around the area in contact with the solution injection nozzle.

[0016] Therefore, the first technical objective of the present invention is to increase the spinning speed by vertically ejecting an air flow onto the periphery of the spun filament flying in the air layer, thereby quickly converting the discharged droplets into spun filaments and suppressing the generation of fine droplets.

[0017] A second technical objective of the present invention is to eject an air flow perpendicularly onto the periphery of the spun filament flying in the air layer without affecting the tip of the spinning nozzle.

[0018] Other objects and advantages of the present invention can be understood from the following description and become more apparent from the embodiments of the present invention, and can be realized by the means and combinations thereof set forth in the claims. [Means for solving the problem]

[0019] In order to solve the above-mentioned technical problems, an electrospinning nozzle block according to a first aspect of the present invention includes an internal space for accommodating a spinning solution transferred and injected from a solution storage tank, a nozzle body including a plurality of solution distribution ports, an electrospinning nozzle including an airflow jetting means, a nozzle adapter for detachably connecting the electrospinning nozzle to the nozzle body, and a high voltage applying means for applying high voltage electricity from a high voltage generator to the spinning solution accommodated in the internal space of the nozzle body, and the electrospinning nozzle includes an internal nozzle part body into which a spinning solution as a first fluid is injected, an internal needle part connected to the internal nozzle part body and including a hollow tubular internal needle as an outlet for the first fluid, and an external nozzle part body into which air as a second fluid is injected. a gas ejection means coupled to an end of the external nozzle body and configured to generate a stream of air as the second fluid that moves straight while surrounding the spun filament discharged from the internal needle at a distance from the discharge port, wherein the gas ejection means includes a central hole through which the internal needle passes and a plurality of gas ejection ports arranged radially around the central hole at a predetermined distance apart, wherein the high-voltage application means includes a highly conductive high-voltage application needle that corresponds one-to-one to the electrospinning nozzle, and a high-voltage body that fixes and positions the high-voltage application needle in a width direction, and the nozzle body is configured to have a plurality of holes through which the high-voltage application needle passes, facing the opposite side to the coupling side of the electrospinning nozzle.

[0020] The second aspect of the present invention is characterized in that, in the electrospinning nozzle block of the first aspect, the gas outlet comprises a plurality of air holes, at least two of which are arranged at regular intervals in a plurality of circumferential regions consisting of at least one row of circular lines around the central hole, and which discharge the second fluid, air, to the outside.

[0021] A third aspect of the present invention is characterized in that, in the electrospinning nozzle block of the second aspect, the gas outlet includes a first gas outlet in which at least two air holes are arranged in a first circumferential region that is a first circular line spaced apart from the central hole by a radius r1 and surrounding the central hole, and a second gas outlet in which at least two air holes are arranged in a second circumferential region that is a second circular line spaced apart from the central hole by a radius r2 and surrounding the central hole, and the radius r2 of the second circumferential region is greater than the radius r1 of the first circumferential region.

[0022] A fourth aspect of the present invention is characterized in that, in the electrospinning nozzle block of the third aspect, a plurality of n-th circumferential regions (where n is a natural number greater than or equal to 3) are further arranged outside the second circumferential region surrounding the second circumferential region, and at least two air holes are arranged in the n-th circumferential region.

[0023] A fifth aspect of the present invention is characterized in that, in the electrospinning nozzle block of the fourth aspect, six air holes are arranged at an angle of 60° to each other in the first circumferential region, the second circumferential region, and the nth circumferential region.

[0024] In a sixth aspect of the present invention, in the electrospinning nozzle block of the fifth aspect, the gas ejection means includes a side fastening part coupled to an end extending from the external nozzle part body, and a cover part having the central hole and a plurality of gas outlets arranged surrounding the central hole, and is an air cap in which a retention space for the second fluid, air, is formed by the side fastening part and the cover part.

[0025] A seventh aspect of the present invention is characterized in that the electrospinning nozzle block of the sixth aspect further includes a hollow tubular guide needle that guides the high-voltage application needle so that it can stably enter the hole, the guide needle being disposed between the high-voltage body and the nozzle body, and the inner diameter of the guide needle being larger than the diameter of the high-voltage application needle.

[0026] The eighth aspect of the present invention is characterized in that, in the electrospinning nozzle block of the sixth aspect, the high voltage application needle is arranged coaxially inside the internal needle of the electrospinning nozzle or coaxially inside the solution storage space of the internal nozzle body.

[0027] A ninth aspect of the present invention is characterized in that the electrospinning nozzle block of the sixth aspect further comprises a linear reciprocating device for reciprocating the high voltage application means up and down along the longitudinal direction of the nozzle.

[0028] A tenth aspect of the present invention is characterized in that, in the electrospinning nozzle block of the sixth aspect, the electrospinning nozzles attached to the nozzle body are arranged at intervals of 20 mm to 70 mm.

[0029] An eleventh aspect of the present invention is the electrospinning nozzle block of the sixth aspect, characterized in that the high-voltage body is composed of a circular or square rod made of a metal material that conducts electricity inside an insulating cylindrical pipe or a square pipe, and the high-voltage application needles are connected one-to-one to the metal rod.

[0030] A twelfth aspect of the present invention is the electrospinning nozzle block of the sixth aspect, characterized in that the high voltage application needle is a hollow metal needle or a metal wire.

[0031] An electrospinning nozzle block according to a thirteenth aspect of the present invention includes an internal space for accommodating a spinning solution transferred from a solution storage tank and injected therein, a nozzle body including a plurality of solution distribution ports, an electrospinning nozzle including an airflow jetting means, a nozzle adapter for detachably connecting the electrospinning nozzle to the nozzle body, and a high voltage applying means for applying high voltage electricity from a high voltage generator to the spinning solution accommodated in the internal space of the nozzle body, wherein the electrospinning nozzle includes an internal nozzle body into which a first fluid is injected, an internal needle part connected to the internal nozzle body and having a hollow tubular internal needle as an outlet for the first fluid, an external nozzle body into which a second fluid is injected, an external needle part connected to the external nozzle body and having a hollow tubular external needle as an outlet for the second fluid, and a center of the external needle the electrospinning nozzle includes an outer needle position adjusting unit for adjusting the position of an axis; a gas inlet for injecting air; and a gas ejection means coupled to an end of the outer needle position adjusting unit for generating a straight air flow surrounding a spun filament discharged from a double needle including an outer needle coaxially surrounding the inner needle at a distance from the ejection port, the gas ejection means including a central hole through which the double needle passes and a plurality of gas ejection ports disposed radially around the central hole at a predetermined distance apart. The high-voltage application means includes a highly conductive high-voltage application needle corresponding to the electrospinning nozzle one-to-one, and a high-voltage body for fixing and disposing the high-voltage application needle in a width direction, and the nozzle body has a plurality of holes through which the high-voltage application needle passes, the holes facing the opposite side to the coupling side of the electrospinning nozzle.

[0032] A 14th aspect of the present invention is characterized in that, in the electrospinning nozzle block of the 13th aspect, the external needle position adjustment unit includes a cylindrical position adjustment unit body that is arranged between the external needle portion and the gas ejection means to form a gas flow path, and a plurality of screw pins that are provided in a part of the position adjustment unit body and that adjust the central axis of the external needle.

[0033] A 15th aspect of the present invention is characterized in that, in the electrospinning nozzle block of the 14th aspect, the gas inlet is formed at one end of the position adjustment unit body, and air injected through the gas inlet is discharged to the gas ejection means.

[0034] A 16th aspect of the present invention is characterized in that, in the electrospinning nozzle block of the 15th aspect, a plurality of the screw pins are arranged around the outer needle at a certain angle apart from each other around a portion of the position adjustment unit body.

[0035] A 17th aspect of the present invention is characterized in that, in the electrospinning nozzle block of the 16th aspect, the inner diameter of the outer needle is 5 μm to 1000 μm larger than the outer diameter of the inner needle, and the distance between the central axis of the inner needle and the central axis of the outer needle is within 0.1 mm.

[0036] In an 18th aspect of the present invention, in the electrospinning nozzle block of the 16th aspect, the gas outlet comprises a plurality of air holes, at least two of which are arranged at regular intervals in a plurality of circumferential regions consisting of at least one row of circular lines around the central hole, and which discharge the second fluid, air, to the outside.

[0037] A 19th aspect of the present invention is characterized in that, in the electrospinning nozzle block of the 18th aspect, the gas outlet includes a first gas outlet in which at least two air holes are arranged in a first circumferential region that is a first circular line spaced apart from the central hole by a radius r1 and surrounding the central hole, and a second gas outlet in which at least two air holes are arranged in a second circumferential region that is a second circular line spaced apart from the central hole by a radius r2 and surrounding the central hole, and the radius r2 of the second circumferential region is greater than the radius r1 of the first circumferential region.

[0038] A 20th aspect of the present invention is characterized in that, in the electrospinning nozzle block of the 19th aspect, a plurality of nth circumferential regions (where n is a natural number greater than or equal to 3) are further arranged outside the second circumferential region surrounding the second circumferential region, and at least two air holes are arranged in the nth circumferential region.

[0039] A 21st aspect of the present invention is characterized in that, in the electrospinning nozzle block of the 20th aspect, six air holes are arranged at an angle of 60° to each other in the first circumferential region, the second circumferential region, and the nth circumferential region.

[0040] A 22nd aspect of the present invention is characterized in that, in the electrospinning nozzle block of the 21st aspect, the gas ejection means includes a side fastening part coupled to an end extending from the external needle position adjusting part, and a cover part having the central hole and a plurality of gas outlets arranged surrounding the central hole, and is an air cap in which a retention space for the air is formed by the side fastening part and the cover part.

[0041] A 23rd aspect of the present invention is characterized in that the electrospinning nozzle block of the 22nd aspect further includes a hollow tubular guide needle that guides the high-voltage application needle so that it can stably enter the hole, the guide needle being disposed between the high-voltage body and the nozzle body, and the inner diameter of the guide needle being larger than the diameter of the high-voltage application needle.

[0042] The 24th aspect of the present invention is characterized in that, in the electrospinning nozzle block of the 22nd aspect, the high voltage application needle is coaxially arranged inside the internal needle of the electrospinning nozzle or coaxially arranged inside the solution storage space of the internal nozzle body.

[0043] The electrospinning nozzle block according to a twenty-fifth aspect of the present invention includes an electrospinning nozzle block having an internal space for accommodating a spinning solution transferred from a solution storage tank and injected therein, a nozzle body including a plurality of solution distribution ports, an electrospinning nozzle including an airflow jetting means, a nozzle adapter for detachably connecting the electrospinning nozzle to the nozzle body, and a high voltage applying means for applying high voltage electricity from a high voltage generator to the spinning solution accommodated in the internal space of the nozzle body, wherein the electrospinning nozzle includes an internal nozzle body including a first fluid inlet through which a first fluid is injected, an internal needle part connected to the internal nozzle body and having a hollow tubular internal needle as an outlet for the first fluid, an external nozzle body including a second fluid inlet through which air as a second fluid is injected, a needle shaft for controlling and blocking the flow of the first fluid transferred to the internal needle part, and a needle sleeve. the electrospinning nozzle includes an air pressure control unit body having a needle shaft sealing unit for preventing the first fluid from flowing back and leaking above the shaft; and a gas ejection means coupled to an end of the outer nozzle body and generating a stream of air as the second fluid that moves straight while surrounding the spun filament ejected from the inner needle at a distance from the ejection port, the gas ejection means including a central hole through which the inner needle passes and a plurality of gas ejection ports arranged radially around the central hole at a predetermined distance apart. The high-voltage application means includes a highly conductive high-voltage application needle that corresponds one-to-one to the electrospinning nozzle, and a high-voltage body that fixes and positions the high-voltage application needle in a width direction, and the nozzle body has a plurality of holes through which the high-voltage application needle passes, facing the opposite side to the coupling side of the electrospinning nozzle.

[0044] In a 26th aspect of the present invention, in the electrospinning nozzle block of the 25th aspect, the air pressure control unit body further includes an air inlet for injecting air into the needle shaft, and the needle shaft includes: a spring wound around the needle shaft and having elastic restoring force; a tapered blocking portion formed at an end of the needle shaft to block a fluid passage toward the inner needle portion and block the flow of the first fluid; and a pointed-ended shaft needle connected to the tapered blocking portion, penetrating the inner needle and protruding from a tip end thereof.

[0045] A 27th aspect of the present invention is characterized in that, in the electrospinning nozzle block of the 26th aspect, the gas outlet comprises a plurality of air holes, at least two of which are arranged at regular intervals in a plurality of circumferential regions consisting of at least one row of circular lines around the central hole, and which discharge the second fluid, air, to the outside.

[0046] A 28th aspect of the present invention is the electrospinning nozzle block of the 27th aspect, wherein the gas outlets include a first gas outlet in which at least two air holes are arranged in a first circumferential region that is a first circular line spaced apart from the central hole by a radius r1 and surrounding the central hole, and a second gas outlet in which at least two air holes are arranged in a second circumferential region that is a second circular line spaced apart from the central hole by a radius r2 and surrounding the central hole, and the radius r2 of the second circumferential region is greater than the radius r1 of the first circumferential region.

[0047] A 29th aspect of the present invention is characterized in that, in the electrospinning nozzle block of the 28th aspect, a plurality of nth circumferential regions (where n is a natural number greater than or equal to 3) are further arranged outside the second circumferential region surrounding the second circumferential region, and at least two air holes are arranged in the nth circumferential region.

[0048] A 30th aspect of the present invention is characterized in that, in the electrospinning nozzle block of the 29th aspect, six air holes are arranged at an angle of 60° to each other in the first circumferential region, the second circumferential region, and the nth circumferential region.

[0049] In a 31st aspect of the present invention, in the electrospinning nozzle block of the 30th aspect, the gas ejection means includes a side fastening part coupled to an end extending from the external nozzle part body, and a cover part having the central hole and a plurality of gas outlets arranged surrounding the central hole, and is an air cap in which a retention space for the second fluid, air, is formed by the side fastening part and the cover part.

[0050] A 32nd aspect of the present invention is the electrospinning nozzle block of the 31st aspect, further comprising a hollow tubular guide needle that guides the high-voltage application needle so that it can stably enter the hole, the guide needle being disposed between the high-voltage body and the nozzle body, and the inner diameter of the guide needle being larger than the diameter of the high-voltage application needle.

[0051] A 33rd aspect of the present invention is characterized in that, in the electrospinning nozzle block of the 31st aspect, the high voltage application needle is coaxially arranged inside the internal needle of the electrospinning nozzle or coaxially arranged inside the solution storage space of the internal nozzle body.

[0052] The electrospinning apparatus according to the 34th aspect of the present invention is characterized by comprising: an unwinding section as an unwinding section that unwinds a roll on which a substrate for spinning a spinning solution to laminate nanofibers is wound; a winding section as a winding section that winds the substrate on which nanofibers are laminated; at least one nozzle block array formed by connecting at least one electrospinning nozzle block of any one of the 1st to 33rd aspects in the width direction of the substrate; a collector for laminating nanofibers spun from at least one of the nozzle block arrays while transporting the substrate; a solution storage tank for storing the spinning solution; a solution transfer device for transferring the spinning solution from the solution storage tank to the spinning nozzle of the modular electrospinning nozzle block; and a high-voltage power supply device for applying a high DC voltage to the spinning solution.

[0053] The 35th aspect of the present invention is characterized in that, in the electrospinning apparatus of the 34th aspect, it further includes: a robot driving unit for driving the nozzle block array back and forth along the width direction of the substrate; a spinning distance adjusting unit for moving the nozzle block array up and down to adjust the distance between the collector and the tip of the spinning needle; and stacking guide units arranged on the left and right of the nozzle block array in the direction in which the substrate is transported, for stacking the spun nanofibers in a limited area of ​​the collector.

[0054] The 36th aspect of the present invention is characterized in that the electrospinning apparatus of the 35th aspect further includes a hot air generator for volatilizing the solvent from a large amount of spun filaments spun from the spinning needles of the nozzle block array to produce fine nanofibers, a humidity regulator for controlling the evaporation rate of the solvent by adjusting the internal humidity of the electrospinning apparatus, and a laminator for adjusting the bonding state of the nanofibers laminated on the substrate. [Effects of the Invention]

[0055] According to one aspect of the present invention, the following effects can be obtained from an electrospinning nozzle block and an electrospinning apparatus including an electrospinning nozzle having multiple gas outlets at a certain distance from a central hole through which a spinning needle passes.

[0056] First, nanofibers can be produced more efficiently from the discharged droplets without generating fine droplets, and a uniform nanofiber web can be produced.

[0057] Second, the evaporation rate of the solvent can be increased, and the output amount of the solution can be increased, thereby increasing the production rate of nanofibers.

[0058] Third, by generating a straight air layer flow around the spun filament flying in whipping mode in the air layer section, it does not directly affect the solution outlet of the nozzle, thereby preventing the solution from solidifying at the nozzle tip.

[0059] The following drawings attached to this specification illustrate preferred embodiments of the present invention and, together with the detailed description of the invention, are intended to facilitate a better understanding of the technical concepts of the present invention; therefore, the present invention should not be interpreted as being limited to the matters described in the drawings. [Brief explanation of the drawings]

[0060] [Figure 1] FIG. 1 is a cross-sectional view of an electrospinning nozzle according to a first preferred embodiment of the present invention. [Figure 2] FIG. 2 is a cross-sectional view of the gas ejection means of the electrospinning nozzle of FIG. 1 taken along line AA. [Figure 3] 3 is a vertical cross-sectional view of the gas ejection means of FIG. 2 taken along line BB. [Figure 4] FIG. 2 is a cross-sectional view of an electrospinning nozzle according to a second embodiment of the present invention. [Figure 5] FIG. 10 is a cross-sectional view of an electrospinning nozzle according to a third embodiment of the present invention. [Figure 6] 1 is a schematic perspective view showing the configuration of an electrospinning nozzle block to which an electrospinning nozzle according to an embodiment of the present invention is applied; [Figure 7] FIG. 7 is a perspective view showing a downward roll-to-roll electrospinning apparatus in which a plurality of electrospinning nozzle blocks shown in FIG. 6 are arranged in succession. DETAILED DESCRIPTION OF THE INVENTION

[0061] Since the present invention is susceptible to various modifications and embodiments, specific embodiments will be illustrated in the drawings and described in detail. However, the present invention is not limited to the specific embodiments, and it is understood that the present invention includes all modifications, equivalents, and alternatives within the spirit and technical scope of the present invention.

[0062] When a component is said to be "coupled" or "connected" to another component, this includes not only when the component is directly coupled or connected to the other component, but also when there are other components intervening.

[0063] However, when an element is said to be "directly coupled" or "directly connected" to another element, it is understood that there are no other elements intervening therebetween.

[0064] The terms used in this specification are merely used to describe specific embodiments and are not intended to limit the present invention. The singular expressions include the plural expressions unless otherwise clearly indicated in the context. In the present specification, the terms "comprise" or "have" indicate the presence of features, numbers, steps, operations, components, parts, or combinations thereof described in the specification, and do not preclude the presence or additional possibility of one or more other features, numbers, steps, operations, components, parts, or combinations thereof.

[0065] Unless otherwise defined, all terms used herein, including technical or scientific terms, have the same meaning as commonly understood by a person of ordinary skill in the art to which this invention pertains. Terms defined in commonly used dictionaries are to be interpreted as meanings consistent with the contextual meaning of the relevant art, and are not to be interpreted in an idealized or overly formal sense unless specifically defined in this application.

[0066] The terms and words used in this specification and claims should not be construed as being limited to their ordinary or dictionary meanings, but should be construed as meanings and concepts that correspond to the technical concepts of the present invention, based on the principle that the inventor himself can appropriately define the concepts of terms in order to best describe his invention. Furthermore, unless otherwise defined, the technical and scientific terms used have the meanings commonly understood by those of ordinary skill in the art to which the present invention pertains. In the following description and the accompanying drawings, descriptions of well-known functions and configurations that may obscure the gist of the present invention will be omitted. The accompanying drawings are provided for illustrative purposes only to fully convey the concepts of the present invention to those skilled in the art. Therefore, the present invention is not limited to the accompanying drawings and may be embodied in other forms. Furthermore, the same reference numerals refer to the same components throughout the specification. Please note that the same reference numerals are used to refer to the same components in the drawings whenever possible.

[0067] DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Preferred embodiments of the present invention will now be described in detail with reference to the accompanying drawings, in which: The drawings are not drawn to scale, and like reference numerals in different drawings refer to like elements.

[0068] <Electrospinning nozzle> First Embodiment FIG. 1 is a cross-sectional view showing the configuration of an electrospinning nozzle equipped with a gas ejection means according to a first embodiment of the present invention.

[0069] Referring to FIG. 1, the electrospinning nozzle 100 according to the present embodiment includes an inner nozzle body 101 into which a spinning solution, which is a first fluid, is injected; an outer nozzle body 102 into which air, which is a second fluid, is injected; an inner needle 103 having a hollow needle 103a serving as an outlet for the first fluid; a gas ejection means 104 coupled to an end of the outer nozzle body 102 and configured to generate a flow of air, which is the second fluid, that moves straight while surrounding the charged filaments formed by the spinning solution ejected from the hollow needle 103a at a distance from the outlet; and a high voltage application means 106 connected to the inner nozzle body 101.

[0070] The internal nozzle body 101 is composed of a first fluid inlet 101a, which is an inlet through which the first fluid, the spinning solution, is injected, a solution storage space 101b in which the spinning solution flows and accumulates, and a tapered outlet 101c that delivers the spinning solution to the internal needle 103a.

[0071] The inner needle 103 is detachably coupled to the inner nozzle body 101 through an inner needle fastening cap 105 .

[0072] The inner nozzle body 101 may have a screw thread on the outer surface thereof for fastening to a specific external fastening part (not shown).

[0073] A syringe or male fitting having a double-threaded luer lock structure outlet, or a tube fastening fitting, may be connected to the first fluid inlet 101a of the inner nozzle body 101. The outlet 101c of the inner nozzle body 101 is configured in a luer taper shape so as to abut and closely couple with the socket portion of the inner needle 103. The solution storage space 101b of the inner nozzle body 101 may be used as a flow path for transporting the spinning solution or as a storage space for temporarily retaining the solution.

[0074] The connection standard of the Luer taper of the outlet 101c of the inner nozzle body 101 is in accordance with the ISO 594 standard {ISO 594-1:1986 "Conical fittings with a 6% (Luer) taper for syringes, needles and certain other medical equipment". [1](https: / / www.iso.org / standard / 4693.html)}.

[0075] The material of the inner nozzle body 101 is preferably a conductive metal such as stainless steel (SUS), aluminum, copper-based material plated with nickel or chromium, brass-based material plated with nickel or chromium, etc. Meanwhile, when the spinning solution as the first fluid is a biopolymer solution containing cells, the material of the inner nozzle body 101 may be a non-metallic material such as a fluorine-based polymer such as Teflon, PEEK (polyether ether ketone), superhard material, or quartz material.

[0076] A high voltage applying means 106 for applying a DC high voltage of several tens to several tens of thousands of volts is connected to the inner nozzle body 101. Therefore, when a high voltage is applied to the inner nozzle body 101, the spinning solution discharged from the tip of the inner needle 103a is charged by the high voltage.

[0077] The inner needle part 103, which is detachably connected to the inner nozzle part body 101 through the inner needle part fastening cap 105, includes a hollow tubular inner needle 103a for discharging the spinning solution to the outside. The inner needle 103a is connected to the inner needle part 103 via a hub or a sleeve.

[0078] The sleeve may be a hollow tube or may be configured as a hollow screw having an external thread. If the sleeve is configured as a soft and elastic polymer, it becomes easier to replace the hollow needle 103a from the internal needle portion 103. For example, the hollow tube-shaped sleeve is preferably configured as a fire-resistant soft material such as fluorinated ethylene propylene (FEP), perfluoroalkoxyalkane (PFA), or polytetrafluoroethylene (PTFE).

[0079] Furthermore, the sleeve may be made of a conductive polymer material containing carbon or a metal component to provide conductivity to the inner needle 103a through the inner nozzle body 101. The inner diameter of the hollow tubular sleeve is preferably approximately the same as or smaller than the outer diameter of the inner needle 103a to ensure excellent adhesion to the inner needle 103a. That is, the hollow tubular sleeve preferably has an inner diameter of 0.05 mm to 4 mm and an outer diameter of 1 mm to 5 mm. The sleeve may be made of a copper-based material or a non-metallic material containing copper. More preferably, the sleeve may be made of a non-ferrous metal such as brass, nickel-plated brass, or copper, or an aluminum-based material, a stainless steel metal, or a moldable polymer such as PEEK.

[0080] The inner needle 103a preferably has an inner diameter of 0.005 mm to 2 mm, an outer diameter of 0.02 mm to 3 mm, and a length of 2 mm to 200 mm. The material of the inner needle 103a is preferably stainless steel (SUS), silica, quartz, super hard, fluorine, or SUS coated with PEEK.

[0081] The tip of the inner needle 103a may be in the form of a blunt end or a pointed end, where the edge angle of the blunt end may be a sharp tip with a 90° angle, a chamfered tip with rounded corners, or a tapered tip with a gradually tapered end.

[0082] An inner needle part fastening cap 105 is used when connecting the inner needle part 103 to the inner nozzle part body 101. The inner needle part fastening cap 105 has a semicircular groove structure on which the hub of the inner needle part 103 is placed or a luer lock structure.

[0083] If the inner needle part fastening cap 105 has a semicircular groove structure, the inner needle part 103 is placed in the groove of the inner needle part fastening cap 105, and then when the cap 105 is turned, the socket part of the hub of the inner needle part 103 is pushed up against the upper end of the taper and abuts against it to be coupled. On the other hand, if the inner needle part fastening cap 105 has a luer lock structure with a double-start screw thread inside, when the hub of the inner needle part 103 is turned, it is pushed up against the upper end of the taper and coupled.

[0084] The outer nozzle body 102 is coupled to the inner nozzle body 101 while surrounding the inner needle 103 and at least a portion of the inner nozzle body 101. The outer nozzle body 102 includes a second fluid inlet 102a for injecting air as a second fluid, and a mounting space in which the inner needle 103 is mounted. The second fluid inlet 102a is configured by a female fitting or a tube fastening fitting coupled to a side portion. The female fitting is preferably made of an insulating material so as not to be affected by an electric field even when a high voltage is applied.

[0085] The gas ejection means 104 is fastened to the lower end of the external nozzle body 102. That is, a fastening tube 102b extending in the longitudinal direction of the nozzle is formed at the lower end of the external nozzle body 102. The fastening tube 102b preferably has an outer diameter smaller than that of the main body of the external nozzle body 102. A screw thread may be formed on the outer surface of the fastening tube 102b for attaching and detaching the gas ejection means 104.

[0086] The gas ejection means 104 is a kind of air cover or air cap that is fastened to the fastening tube 102b of the external nozzle part main body 102 to cover the mounting space of the external nozzle part main body 102 and form a space in which the second fluid, air, is retained.

[0087] The gas ejection means 104 is composed of a side fastening part 104b that is screwed to the fastening tube 102b, and a cover part 104a that covers the installation space and forms an air retention space. The cover part 104a is also formed with a central hole 114 through which the internal needle 103a passes, and a plurality of gas exhaust ports 115 that are arranged surrounding the central hole 114.

[0088] FIG. 2 is a cross-sectional view taken along line AA of the gas ejection means 104 according to the first embodiment of the present invention, and FIG. 3 is a vertical cross-sectional view taken along line BB of the gas ejection means 104 in FIG.

[0089] 2, the gas ejection means 104 is composed of a type of air cap including a central hole 114 through which the inner needle 103a passes and several to several tens of gas ejection ports 115 arranged in at least two circular rows surrounding the central hole 114. The gas ejection ports 115 are air holes for discharging air, which is the second fluid injected through the second fluid inlet 102a, to the outside. As a result, multiple air flowing layers 116 moving in a straight line parallel to the inner needle 103a are formed around the inner needle 103a passing through the central hole 114.

[0090] The gas outlets 115 may be arranged at regular intervals or randomly in a plurality of circumferential regions, each of which comprises at least one circular line centered around the central hole 114. For example, referring to FIG. 2, six first gas outlets 115a are arranged at 60° angles to each other in a first circumferential region 111, which is a first circular line surrounding the central hole 114 and spaced a radius r1 from the central hole 114. Additionally, six second gas outlets 115b are arranged at 60° angles to each other in a second circumferential region 112, which is a second circular line surrounding the central hole 114 and spaced a radius r2 from the central hole 114. In this case, the radius r2 of the second circumferential region 112 is greater than the radius r1 of the first circumferential region 111. That is, the radius r1 is 2 mm to 10 mm, more preferably 3 mm to 5 mm, and the radius r2 is 4 mm to 20 mm, more preferably 4 mm to 10 mm. The gas outlet 115 may be a circular or rectangular hole, but is preferably a circular hole. In this case, if the gas outlet 115 is a circular hole, the diameter of the circular hole is preferably 0.1 mm to 2 mm. The gas outlet 115 may be configured by pressing a hollow needle with an inner diameter of 0.1 mm to 1 mm into the cover part 104a of the gas ejection means 104, instead of a circular hole.

[0091] 2 shows a configuration in which a total of 12 first gas outlets 115a and second gas outlets 115b are arranged in two circular rows around the central hole 114. However, the gas ejection means 104 of the present invention is not necessarily limited to such an arrangement or configuration.

[0092] In this embodiment, a plurality of n-th circumferential regions (where n is a natural number equal to or greater than 3) surrounding the second circumferential region 112 may be further arranged outside the second circumferential region 112. In addition, more than six gas outlets or fewer than six gas outlets may be arranged in the first circumferential region 111, the second circumferential region 112, and the n-th circumferential region (where n is a natural number equal to or greater than 3). In addition, the plurality of gas outlets 115 arranged in one circumferential region may be arranged at a certain angle (e.g., 60°) from each other, or may be arranged randomly without any angular rule.

[0093] The diameter of the central hole 114 is approximately the same as or slightly larger than the outer diameter of the hollow needle 103a that passes through the central hole 114. For example, the diameter of the central hole 114 is preferably 0.001 mm to 0.5 mm larger than the outer diameter of the hollow needle 103a. It is more preferable to set the diameter of the central hole 114 to 0.001 mm to 0.1 mm larger than the outer diameter of the hollow needle 103a to prevent a gap from forming between the central hole 114 and the hollow needle 103a, thereby preventing air, the second fluid, from leaking through the gap. The inlet portion of the central hole 114 through which the internal needle 103a passes is preferably chamfered to allow the internal needle 103a to pass easily. The thickness h1 of the cover portion 104a, which is the bottom surface of the air cap serving as the gas ejection means 104, is preferably 0.1 mm to 5 mm. More preferably, the thickness h1 of the cover portion 104a is 0.5 mm to 2 mm. At this time, if the thickness h1 of the cover portion 104a exceeds 5 mm, it is difficult to drill a small diameter hole.

[0094] In order to prevent leakage of air injected into the external nozzle part body 102, an O-ring may be provided between the fastening tube 102b of the external nozzle part body 102 and the side fastening part 104b of the gas ejection means 104. In this case, the O-ring may be made of a fluorine-based material, Viton (registered trademark), an ethylene-propylene olefin-based material, or a silicone-based material.

[0095] Furthermore, the hollow needle 103a penetrates through the central hole 114 of the air cap (gas ejection means 104) and protrudes, and the protruding length at this time is preferably 1 mm to 10 mm.

[0096] The operation of the electrospinning nozzle according to this embodiment will be described in detail below.

[0097] First, a spinning solution, which is a first fluid, is injected through a first fluid inlet 101a, and the spinning solution is discharged from the tip of an internal needle 103a. At this time, air, which is a second fluid, is injected through a second fluid inlet 102a, and the air is discharged through a plurality of gas outlets 115 provided in an air cap, which is a gas discharge means 104. The spinning solution discharged from the internal needle 103a passes through a conical Taylor cone to generate a filament jet of a certain length, and then passes through a whipping mode in which the filament jet whips suddenly at a specific position, and the solvent evaporates, and the filament jet is deposited as nanofibers in the accumulation portion.

[0098] The filament jet flies within a certain region in the air layer, and the air flow ejected from the gas outlet 115 and moving straight pushes the filament jet toward the accumulating portion within a range spaced a certain distance from the filament jet, forming a straight-moving air flow layer. This prevents the filament jet from excessively spreading or dispersing outward in the whipping mode. The straight-moving air flow concentrates the charged filaments in the whipping mode section. As a result, charged filaments are stably formed from the spinning solution and are concentrated and stacked in the desired stacking region of the accumulating portion.

[0099] Second Embodiment FIG. 4 is a cross-sectional view showing the configuration of an electrospinning nozzle according to a second embodiment of the present invention.

[0100] The electrospinning nozzle 300 according to the second embodiment of the present invention is characterized in that it further includes an outer needle coaxially surrounding the inner needle and an outer needle position adjusting unit for adjusting the position of the central axis of the outer needle, in addition to the configuration of the electrospinning nozzle 100 according to the first embodiment. That is, the electrospinning nozzle 300 according to this embodiment is substantially identical to the electrospinning nozzle 100 according to the first embodiment, except that it further includes an outer needle unit 304 and an outer needle position adjusting unit 306. Therefore, detailed descriptions of the configuration of the electrospinning nozzle 300 according to this embodiment that is the same as that of the electrospinning nozzle 100 according to the first embodiment will be omitted.

[0101] 4, the electrospinning nozzle 300 according to the present embodiment includes an inner nozzle part body 301 into which a first fluid is injected, an outer nozzle part body 302 into which a second fluid is injected, an inner needle part 303 connected to the inner nozzle part body 301 and having a hollow tubular inner needle 303a as an outlet for the first fluid, an outer needle part 304 connected to the outer nozzle part body 302 and having a hollow tubular outer needle 304c as an outlet for the second fluid arranged to coaxially surround the inner needle 303a, an outer needle position adjusting part 306 for adjusting the position of the central axis of the outer needle 304c, a gas ejection means 307 connected to the outer needle position adjusting part 306 for ejecting gas around the double needle consisting of the outer needle 304c coaxially surrounding the inner needle 303a, and a high voltage applying means 308 connected to the inner nozzle part body 301.

[0102] The second fluid to be injected into the outer needle portion 304 is injected through a second fluid inlet 302a, and a gas (eg, air) is injected through a gas inlet 306d.

[0103] The outer needle part 304 includes a holder 304a into which an outer needle 304c having a sleeve 304b is pushed and coupled. A hole (hole) and threads into which the sleeve 304b is pushed are formed in the holder 304a of the outer needle part 304. In this case, it is preferable that the diameter of the hole of the holder 304a is processed to be slightly smaller than the outer diameter of the sleeve 304b so that liquid leakage does not occur after the sleeve 304b of the outer needle 304c is pushed in.

[0104] The opening of the hole in holder 304a is preferably slightly rounded (R-processed) so that sleeve 304b can be easily inserted. If sleeve 304b is threaded, it is preferable to use a unified national fine (UNF) M2 to M5 screw, preferably an M3 screw, to prevent leakage from the thread.

[0105] The external needle position adjustment part 306 includes a cylindrical position adjustment part body 306a that is disposed between the external needle part 304 and the gas ejection means 307 to form a gas flow path, and a plurality of screw pins 306b that are provided in a part of the position adjustment part body 306a and that are used to adjust the central axis of the external needle 304c.

[0106] A gas inlet 306d is connected to one end of the position adjustment part body 306a, and gas (air) injected from the gas inlet 306d is discharged through the gas flow path to a plurality of gas outlets 307a formed in the gas outlet means 307.

[0107] In addition, a fastening tube 306c is formed at the lower end of the position-adjusting unit body 306a to be coupled to a side fastening portion of the gas ejection means 307. That is, the fastening tube 306c extending in the longitudinal direction of the nozzle is formed at the lower end of the position-adjusting unit body 306a. The fastening tube 306c preferably has an outer diameter smaller than that of the position-adjusting unit body 306a. A screw thread may be formed on the outer surface of the fastening tube 306c for attaching and detaching the gas ejection means 307.

[0108] The plurality of screw pins 306b are arranged around a portion of the position adjusting unit body 306a, spaced apart from each other at a predetermined angle (for example, 60° intervals) to surround the outer needle 304c. In this case, the plurality of screw pins 306b may be arranged in a line around the outer needle 304c or in a zigzag pattern.

[0109] At least one, preferably six, screw pins 306b are arranged at 60° intervals to adjust the central axis of the outer needle 304c. At this time, the central position of the outer needle 304c is adjusted to match the central position of the inner needle 303a arranged coaxially inside. By adjusting the central axis of the outer needle 304c relative to the inner needle 303a in this manner, the inner needle 303a and the outer needle 304c can be arranged coaxially or non-coaxially with each other.

[0110] The diameter of the screw pin 306b is preferably 0.5 mm to 5 mm. The tip of the screw pin 306b is preferably pointed or U-shaped. When the inner needle 303a and the outer needle 304c are arranged coaxially, it is preferable to adjust the distance between the central axis of the inner needle 303a and the central axis of the outer needle 304c to within 0.1 mm.

[0111] The outer diameter of the position-adjusting unit body 306a is preferably 5 mm to 50 mm, and the inner diameter is preferably 2 mm to 45 mm. The position-adjusting unit body 306a may be made of any one of SUS metal, aluminum, brass, PEEK, acetal, and nylon. When the position-adjusting unit body 306a is made of an electrically conductive metal material, applying a high voltage to the outer needle position-adjusting unit 306 can achieve stable spinning at the tip of the inner needle 303a.

[0112] In the electrospinning nozzle 300 according to this embodiment, the inner diameter of the outer needle 304c is configured to be 5 μm to 1000 μm larger than the outer diameter of the inner needle 303a. For example, in the electrospinning nozzle according to this embodiment, the inner needle 303a and the outer needle 304c are configured to be 17G-23G [17G (OD: 1.47 mm, ID: 1.07 mm)], 23G (OD: 0.63 mm, ID: 0.33 mm)], 17G-25G [17G (OD: 1.47 mm, ID: 1.07 mm), 25G (OD: 0.50 mm, ID: 0.25 mm)], 18G-25G [18G (OD: 1.27 It is preferable to have any one combination of 21G-27G [21G (OD: 0.80mm, ID: 0.50mm), 27G (OD: 0.40mm, ID: 0.20mm)] and 22G-30G [22G (OD: 0.70mm, ID: 0.40mm), 30G (OD: 0.30mm, ID: 0.15mm)]].

[0113] Gas ejection means 307, which includes a central hole 307d through which outer needle 304c coaxially (or non-coaxially) surrounds inner needle 303a passes and a plurality of gas ejection ports 307a, is connected to a fastening tube 360c formed at the lower end of the position adjustment unit body 306a. The central hole 307d is sealed by fastening a thin silicone plate 307d or an O-ring and a hollow screw 307b. The length by which outer needle 304c protrudes from central hole 307d to the outside is preferably 1 to 10 mm from the lower end of gas ejection means 307.

[0114] The gas ejection means 307 according to this embodiment has the same configuration and function as the gas ejection means 104 shown in FIGS. 2 and 3 of the first embodiment.

[0115] Hereinafter, the operation of the electrospinning nozzle 300 according to this embodiment will be described in detail.

[0116] First, a first spinning solution, which is a first fluid, is injected through a first fluid inlet 301a, and the spinning solution is discharged from the tip of the internal needle 303a. A second fluid, which is a second spinning solution, is injected through a second fluid inlet 302a and discharged to the outside through an external needle 304c. At this time, air is injected through a gas inlet 306d, and the air is discharged through a plurality of gas outlets 307a provided on an air cap, which is a gas discharge means 307. The first spinning solution discharged from the internal needle 303a and the second spinning solution discharged from the external needle 304c pass through a conical Taylor cone to generate a filament jet of a certain length. Then, the filament jet undergoes a whipping mode in which the filament jet rapidly whips at a specific position, and the solvent evaporates, resulting in nanofibers being deposited in the accumulation area.

[0117] The filament jet flies within a certain region in the air layer, and the air flow ejected from the gas outlet 307a and moving straight forms an air fluidized layer moving straight while pushing the filament jet toward the accumulating portion within a range separated by a certain distance from the filament jet, thereby preventing the filament jet from excessively spreading or dispersing outward in the whipping mode. As a result, the spun filaments are laminated as a nanofiber web with a core-shell structure within a desired lamination region of the accumulating portion.

[0118] <Third embodiment> FIG. 5 is a cross-sectional view showing the configuration of an electrospinning nozzle 400 according to a third embodiment of the present invention.

[0119] The electrospinning nozzle 400 according to the third embodiment of the present invention is characterized in that it further includes a needle shaft 411 capable of controlling and blocking the flow of the spinning solution during the electrospinning process in addition to the electrospinning nozzle 100 according to the first embodiment. That is, the electrospinning nozzle 400 according to this embodiment is substantially the same as the electrospinning nozzle 100 according to the first embodiment, except that it further includes a needle shaft 411. Therefore, detailed descriptions of the components of the electrospinning nozzle 400 according to this embodiment that are the same as those of the electrospinning nozzle 100 according to the first embodiment will be omitted.

[0120] Referring to FIG. 5, the electrospinning nozzle 400 according to the present embodiment includes an inner nozzle body 401 including a first fluid inlet 401a through which a first fluid is injected, an inner needle part 403 connected to the inner nozzle body 401 and including a hollow tubular inner needle 403b serving as an outlet for the first fluid, an outer nozzle body 402 including a second fluid inlet 402a through which a gas, which is a second fluid, is injected, an air inlet 410a through which air is injected, and a nozzle 410b for controlling the flow of the first fluid transferred to the inner needle part 403. The device includes an air pressure control unit main body 410 including a needle shaft 411 for controlling and blocking, and a needle shaft sealing unit 412 for preventing the first fluid from flowing back and leaking above the needle shaft 411; a gas ejection means 404 including a central hole 404a through which the internal needle 403b passes, and a plurality of gas ejection ports 404b arranged around the central hole 404a for ejecting the second fluid, gas (air), to the outside; and a high voltage application means 406 connected to the internal nozzle unit main body 101.

[0121] In addition, the electrospinning nozzle 400 of this embodiment, like the second embodiment, may further include an outer needle portion having a hollow tubular outer needle connected to the outer nozzle portion body 302 and arranged to coaxially surround the inner needle 403b, and an outer needle position adjustment portion including a plurality of screw pins for adjusting the position of the central axis of the outer needle.

[0122] The needle shaft 411 includes a tapered blocking portion 411a that blocks the fluid passage toward the inner needle portion 403 to block the flow of the first fluid, and a pointed end shaft needle 411b that penetrates the inner needle 403b and protrudes from its tip.

[0123] The needle shaft 411 is normally kept in an upwardly pushed-up state by the spring restoring force of a spring 413 wound around the shaft. As a result, the fluid passage toward the internal needle portion 403 is opened (ON state), allowing the first fluid to flow into the internal needle portion 403. When air is injected through the air inlet 410a, the spring 413 of the needle shaft 411 is compressed by air pressure, and the tapered blocking portion 411a at the tip of the needle shaft 411 blocks the fluid passage for the first fluid. At the same time, the shaft needle 411b penetrates and protrudes through the internal needle 403b, thereby blocking the hollow of the internal needle 403b.

[0124] The operation of the electrospinning nozzle 400 of this embodiment will be described in detail below.

[0125] First, a spinning solution, which is a first fluid, is injected through the first fluid inlet 401a and discharged from the tip of the internal needle 403b. At this time, air is injected through the second fluid inlet 402a, and the air is discharged through multiple gas outlets 404b provided on the air cap, which is the gas discharge means 404. The spinning solution discharged from the internal needle 403b passes through a conical Taylor cone to generate a filament jet of a certain length. The filament jet then undergoes a whipping mode, in which the filament jet whips rapidly at a specific position, causing the solvent to volatilize and form nanofibers in the accumulation portion. Meanwhile, when the first fluid injected through the first fluid inlet 401a is transported to the internal needle 403, the needle shaft seal 412 prevents the first fluid from flowing back and leaking above the internal needle 403.

[0126] The filament jet flies within a certain region in the air layer, and the air flow ejected from the gas outlet 404b moves straight while pushing the filament jet toward the accumulating part within a range separated by a certain distance from the filament jet, thereby preventing the filament jet from spreading or dispersing excessively outward in a whipping mode, thereby enabling the spun filaments to be concentrated and laminated within a desired lamination region of the accumulating part.

[0127] Meanwhile, by injecting air through the air inlet 410a, the spring 413 of the needle shaft 411 is compressed by air pressure, and the tapered blocking portion 411a at the tip of the needle shaft 411 blocks the fluid passage of the first fluid. At the same time, the shaft needle 411b penetrates the inner needle 403b and blocks the passage of the inner needle 403b, thereby blocking the flow of the first fluid (the spinning solution), and the electrospinning process is interrupted. To resume the electrospinning process, the air injected through the air inlet 410a is blocked and air is injected through the second fluid inlet 402a. With the air injected through the air inlet 410a blocked, the spring 413 of the needle shaft 411 returns to its original position due to its spring restoring force, and the fluid passage of the inner needle portion 403 is converted to an open state, and the electrospinning process is resumed.

[0128] In this way, the needle shaft 411 can easily control the on / off of the flow of the spinning solution injected into the first fluid inlet 401a.

[0129] The air injected from the outside through the air inlet 410 a to control the needle shaft 411 needs to be injected with a pressure equal to or greater than the spring restoring force (tension) of the spring 413 .

[0130] In addition, if the electrospinning nozzle 400 of this embodiment further includes an outer needle coaxially surrounding the inner needle 403b, it may further include a separate gas inlet for injecting another spinning solution into the second fluid inlet 402a and for injecting air ejected from the gas outlet 404b.

[0131] <Electrospinning nozzle block> FIG. 6 is a schematic perspective view showing the configuration of an electrospinning nozzle block to which an electrospinning nozzle according to one embodiment of the present invention is applied.

[0132] Referring to FIG. 6, the electrospinning nozzle block 200 of a preferred embodiment of the present invention includes an internal space for accommodating a spinning solution transferred and injected from a solution storage tank (not shown), a nozzle body 230 including a plurality of solution distribution ports, an electrospinning nozzle 210 selected from the first, second, and third embodiments, a nozzle adapter 220 for detachably connecting the electrospinning nozzle 210 to the nozzle body 230, and a high voltage applying means 240 for applying high voltage electricity from a high voltage generator 250 to the spinning solution accommodated in the internal space of the nozzle body 230.

[0133] The nozzle body 230 is a cylindrical or rectangular pipe having an internal space for receiving the spinning solution from a solution reservoir (not shown). The nozzle body 230 may be a rectangular container including an upper body and a lower body that can be separated or connected to each other.

[0134] The inner space of the nozzle body 230 is used as a space for temporarily storing the spinning solution flowing from the solution storage tank while it is being transferred to the electrospinning nozzle 210, or for temporarily storing the spinning solution when the electrospinning process is temporarily stopped. The height of the inner space may be 1 mm to 30 mm, more preferably 3 mm to 10 mm, when used as a storage space, and may be 20 mm to 500 mm when used as a storage space.

[0135] The nozzle body 230 is preferably made of an insulating material such as PEEK or a fluoropolymer (Teflon). The electrospinning nozzle 210 is detachably connected to the nozzle body 230 through the nozzle adapter 220.

[0136] There are various ways to connect the electrospinning nozzle 210 to the nozzle adapter 220. After pushing the electrospinning nozzle 210 up to the upper end of the nozzle adapter 220, it can be fastened by rotating it 45° to 360° using a fine thread or a double thread, or it can be lifted up and pushed in to fix it.

[0137] The nozzle adapter 220 may be provided with a controllable on / off valve that blocks the flow of the solution to prevent leakage of the spinning solution from the nozzle body 230 after the electrospinning nozzle 210 is separated.

[0138] The spacing between the electrospinning nozzles 210 attached to the nozzle body 230 (the distance between adjacent electrospinning nozzles) is 20 mm to 70 mm. More preferably, when the electrospinning nozzles 210 are arranged at high density to mass-produce nanofibers, the spacing between the electrospinning nozzles 210 is 10 mm to 40 mm.

[0139] The material of the nozzle adapter 220 is preferably a fluorine-based material such as polyether ether ketone (PEEK) or polytetrafluoroethylene (PTFE), or a metal-based material such as stainless steel (SUS).

[0140] The high voltage application means 240 is a means for transmitting a high voltage from a high voltage generator 250 to the spinning solution in the nozzle body 230, and includes high voltage application needles 241 that correspond one-to-one to the electrospinning nozzles 210, and a high voltage body 242 that fixes and arranges the high voltage application needles 241 at a constant width along the width direction (direction perpendicular to the nozzle direction). The high voltage application needles 241 are made of a metal with excellent electrical conductivity.

[0141] Therefore, the nozzle body 230 is formed with a plurality of holes 233 through which the high voltage application needles 241 pass, facing the opposite side of the coupling side of the electrospinning nozzle 210 .

[0142] Therefore, the high voltage application needle 241 penetrates the hole 233 and enters the inner space of the nozzle body 230, and charges the spinning solution retained or stored in the inner space with high voltage.

[0143] Also, the nozzle body 230 may further include a hollow tubular guide needle (not shown) that guides the high voltage application needle 241 so that it can stably enter the hole 233. The guide needle is disposed between the high voltage body 242 and the nozzle body 230 and guides the high voltage application needle 241 so that it can accurately enter the hole 233 of the nozzle body 230. Therefore, the inner diameter of the guide needle needs to be at least larger than the diameter (or outer diameter) of the high voltage application needle 241.

[0144] The high-voltage body 242 may be a round or square rod (hereinafter referred to as "metal rod") made of SUS metal material, which is electrically connected to the inside of a PEEK or PTFE fluorine-based insulating cylindrical or square pipe. The high-voltage application needle 241 is connected to the metal rod in a one-to-one correspondence.

[0145] The high-voltage body 242 may be configured as a cylindrical pipe or a square pipe made of a metal material that can be electrically connected, and a plurality of high-voltage application needles 241 may be configured by being pressed into the high-voltage body 242. In this case, the high-voltage application needles 241 may be configured as hub-type current-carrying needles that can be attached to and detached from an adapter.

[0146] The high-voltage application needle 241 is made of a highly electrically conductive material such as a hollow metal needle or a metal wire. The high-voltage application needle 241 may be coaxially disposed inside the inner needle 103a, 303a, 403b of the electrospinning nozzle 210 or inside the solution storage space 101b of the inner nozzle body 101, 301, 401. In this case, it is preferable that the tip of the high-voltage application needle 241 is located 0 mm to 50 mm inward from the tip of the inner needle 103a, 303a, 403b.

[0147] In addition, the high voltage applying means 240 can be reciprocated up and down in the direction of the nozzle by a linear reciprocating device 245 .

[0148] <Electrospinning device> FIG. 7 is a perspective view showing a downward roll-to-roll electrospinning apparatus 500 in which a plurality of electrospinning nozzle blocks 200 of FIG. 6 are arranged in series.

[0149] For example, a downward roll-to-roll electrospinning apparatus 500 according to one embodiment of the present invention may be configured by arranging four electrospinning nozzle blocks 200 shown in FIG. 6, each having a unit length of 500 mm, in series along the width direction (arrow A) of the substrate to produce a wide nanofiber web having a width of at least 1000 mm.

[0150] Referring to FIG. 7, a downward-type roll-to-roll electrospinning apparatus 500 according to one embodiment of the present invention includes an unwinding unit 501 as an unwinding unit that unwinds a roll on which a substrate is wound for spinning a spinning solution to form nanofibers, a winding unit 502 as a winding unit that winds the substrate on which the nanofibers are formed, at least one (e.g., three) nozzle block array 506 formed by continuously connecting a plurality (e.g., four) electrospinning nozzle blocks 200 shown in FIG. 6 in the width direction (direction of arrow A) of the substrate, a collector 503 for transferring the substrate and forming nanofibers spun from at least one nozzle block array 506, and a solution storage tank (not shown) for storing the spinning solution.

[0151] In addition, the downward roll-to-roll electrospinning apparatus 500 of the present invention further includes a solution transfer device including a plunger for pushing out the solution in the solution storage tank and a solution transfer pump for precisely transferring the spinning solution to the spinning nozzle by operating the plunger; a high-voltage power supply unit 507 for applying a high voltage to the spinning solution to impart a charge of (+) or (-) polarity to the spinning solution so that the spinning solution discharged from the spinning needle of the electrospinning nozzle block 200 is produced as fine fibers having a diameter of nanometers (nm) or micrometers (μm); a robot driving unit 508 for driving the nozzle block array 506 back and forth along the width direction of the substrate; a spinning distance adjusting unit 509 for moving the nozzle block array 506 up and down to adjust the distance between the collector 503 and the tip of the spinning needle; and stacking guide units arranged on the left and right sides of the nozzle block array 506 in the direction in which the substrate is transported, for stacking the spun nanofibers in a limited area of ​​the collector 503.

[0152] The stacking guide unit prevents the nanofibers spun at both ends of the spinning nozzle from being pushed outward and spreading outward, thereby accumulating them in a limited internal region of the collector 503. To this end, the stacking guide unit may be supplied with a high voltage of the same polarity as the high voltage applied to the spinning solution, or may use an airflow.

[0153] In addition, the downward roll-to-roll electrospinning apparatus 500 of the present invention may further include a hot air generator for volatilizing the solvent from a large amount of spun filaments spun from the spinning needles of the nozzle block array 506 to produce fine nanofibers, a humidity controller for controlling the internal humidity of the electrospinning apparatus 500 to control the evaporation rate of the solvent, and a laminator for adjusting the bonding state of the nanofibers laminated on the substrate.

[0154] In addition, the downward roll-to-roll electrospinning apparatus 500 of the present invention may further include a video camera that can monitor in real time the solidification or clogging state of the spinning solution occurring at the tip of the spinning needle or the state of droplets of the Taylor cone formed at the tip of the spinning needle and save the video or image. The video camera is installed at the lower end of the side of the nozzle block array 506 and moves back and forth to check the state of the tip of the spinning needle in real time or take an image.

[0155] According to one embodiment of the present invention, the solution reservoir and the solution transfer pump may be integrally coupled to each other to push out the solution from the solution reservoir. The solution reservoir preferably has a double structure in which the interior is made of stainless steel and the exterior of the stainless steel is coated with a fluorine-based polymer, polyethylene (PE), or polypropylene (PP) as an exterior material. The solution reservoir may be made of an insulating material with excellent voltage resistance, such as polypropylene (PP), polyethylene (PE), polyether ether ketone (PEEK), MC nylon, or acetal. The syringe-type solution reservoir preferably has a capacity of 10 ml to 3000 ml. Meanwhile, the plunger preferably has a Teflon cover or a Teflon seal such as an omniseal at the tip to prevent leakage of the solution from the rear surface of the plunger when pushing out the solution.

[0156] The solution transfer pump comprises a motor, a screw connected to the motor shaft, a pusher fastened to the screw to push a plunger located inside a storage tank, a guide rod connecting the plunger and pusher, a linear motion (LM) guide for smoothly moving the pusher in a linear motion, and a support for fastening and fixing the solution storage tank. The lead of the screw is 0.5 mm to 2 mm, preferably 1 mm. The speed of the pusher moving due to the rotation of the screw is preferably a minimum speed of 1 μm / hour to 100 μm / hour and a maximum speed of 1 cm / minute to 20 cm / minute. The plunger is driven by an external motor to move forward inside the barrel and expel the solution. The plunger of the solution transfer pump may also be driven by air pressure without the operation of an external motor.

[0157] If the capacity of the solution storage tank is insufficient, two solution transfer pumps can be installed in parallel to form a three-way valve to transfer the solution. The flow direction of the valve is open from the first solution pump to the spinning nozzle, and the second solution pump remains closed. When the solution in the solution storage tank of the first transfer pump is depleted, the valve direction switches to close the first transfer pump and open from the second transfer pump to the spinning nozzle. At this time, the depleted solution transfer pump is refilled separately.

[0158] In the spinning process, a solution discharge rate per spinning needle of 0.5 μl / min to 1000 μl / min is suitable for producing nanofibers. A preferred solution discharge rate is 5 μl / min to 300 μl / min. The strength of the applied high voltage is 0.01 kV / cm to 10 kV / cm based on the distance (cm) between the tip of the spinning needle 111b and the collector 503. A more preferred strength of the high voltage is 0.5 kV / cm to 25 kV / cm.

[0159] The nanofiber collecting unit, collector 503, may rotate together with the substrate as it moves. It may be composed of multiple rod rolls, multiple wire rolls, or conveyor-type rolls with electrically conductive surfaces. The rolls may be grounded or may be powered by a DC voltage having a polarity opposite to that of the charged solution. In this case, the strength of the applied voltage having a polarity opposite to that of the solution is 1 kV to 20 kV. The substrate transport speed is preferably 10 cm to 50 m per minute.

[0160] In addition, a hot air injection process is preferably carried out in parallel to volatilize the solvent from the spun filaments discharged during spinning into the atmosphere. At this time, the hot air emitted from the hot air generator is set to a wind speed of 0.1 m / s to 10 m / s and a temperature range of 20°C to 150°C. The temperature of the hot air is preferably 30°C to 80°C.

[0161] As described above, the present invention has been described using limited embodiments and drawings, but the present invention is not limited thereto, and it goes without saying that various modifications and variations can be made by a person having ordinary knowledge in the technical field to which the present invention pertains within the technical spirit of the present invention and the equivalent scope of the claims. [Industrial Applicability]

[0162] According to an electrospinning apparatus using an electrospinning nozzle block according to one embodiment of the present invention, a nanofiber web having micropores can be produced. The nanofiber web can be used as a waterproof and breathable membrane, a filter material for filtering ultrafine dust particles, a scaffold for cell culture, a drug-carrying patch, a sensor material having a high specific surface area, and a flexible electronic material.

Claims

1. An electrospinning nozzle block comprising: an internal space for accommodating a spinning solution transferred and injected from a solution storage tank; a nozzle body including a plurality of solution distribution ports; an electrospinning nozzle including an airflow jetting means; a nozzle adapter for detachably connecting the electrospinning nozzle to the nozzle body; and a high voltage applying means for applying high voltage electricity from a high voltage generator to the spinning solution accommodated in the internal space of the nozzle body, The electrospinning nozzle comprises: an inner nozzle body into which a spinning solution, which is a first fluid, is injected; an inner needle portion connected to the inner nozzle portion body and including a hollow tubular inner needle that is an outlet for the first fluid; an external nozzle body into which air, which is the second fluid, is injected; a gas ejection means coupled to an end of the outer nozzle body, for generating a stream of air, the second fluid, which moves straight while surrounding the spun filament discharged from the inner needle at a distance from the discharge port, the gas ejection means includes a central hole through which the internal needle passes, and a plurality of gas ejection ports arranged radially around the central hole at a predetermined distance apart, The high voltage applying means a highly conductive high voltage application needle that corresponds one-to-one to the electrospinning nozzle; a high voltage body that fixes and arranges the high voltage application needle in the width direction, The nozzle body has a plurality of holes through which the high voltage application needle passes, the holes being formed on the opposite side to the coupling side of the electrospinning nozzle.

2. 2. The electrospinning nozzle block of claim 1, wherein the gas outlet comprises a plurality of air holes, at least two of which are arranged at regular intervals in a plurality of circumferential regions formed by at least one row of circular lines around the central hole, and which discharge the second fluid, i.e., air, to the outside.

3. The gas outlet is The radius r from the central hole １ a first gas outlet in which at least two air holes are arranged in a first circumferential region, which is a first circular line surrounding the central hole and spaced apart by a distance of The radius r from the central hole ２ a second gas outlet in which at least two air holes are arranged in a second circumferential region that is a second circular line surrounding the central hole and spaced apart by a distance of the radius r of the second circumferential region ２ is the radius r of the first circumferential region １ The electrospinning nozzle block of claim 2 , wherein the nozzle block is greater than

4. a plurality of n-th circumferential regions are further disposed outside the second circumferential region and surrounding the second circumferential region, where n is a natural number equal to or greater than 3; The electrospinning nozzle block of claim 3 , wherein at least two air holes are arranged in the nth circumferential region.

5. 5. The electrospinning nozzle block of claim 4, wherein six air holes are arranged at an angle of 60° to each other in the first circumferential region, the second circumferential region, and the nth circumferential region.

6. The gas ejection means is a side fastening part coupled to an end extending from the external nozzle part body; and a cover part having the central hole and a plurality of gas discharge ports arranged to surround the central hole, The electrospinning nozzle block according to claim 5 , wherein the side fastening portion and the cover portion form an air cap inside which a retaining space for the second fluid, i.e., air, is formed.

7. The high voltage application needle further includes a hollow tubular guide needle for guiding the high voltage application needle so that the high voltage application needle can stably enter the hole, 7. The electrospinning nozzle block of claim 6, wherein the guide needle is disposed between the high-voltage body and the nozzle body, and the inner diameter of the guide needle is larger than the diameter of the high-voltage application needle.

8. 7. The electrospinning nozzle block according to claim 6, wherein the high-voltage application needle is coaxially arranged inside the inner needle of the electrospinning nozzle or coaxially arranged inside the solution storage space of the inner nozzle body.

9. The electrospinning nozzle block of claim 6, further comprising a linear reciprocating device for reciprocating the high voltage application means up and down along the longitudinal direction of the nozzle.

10. The electrospinning nozzle block according to claim 6, wherein the electrospinning nozzles attached to the nozzle body are arranged at intervals of 20 mm to 70 mm.

11. 7. The electrospinning nozzle block according to claim 6, wherein the high-voltage body is composed of a circular or square rod made of a metal material that is electrically conductive inside an insulating cylindrical or square pipe, and the high-voltage application needles are connected to the metal rods in a one-to-one relationship.

12. The electrospinning nozzle block according to claim 6 , wherein the high voltage application needle is a metal hollow needle or a metal wire.

13. An electrospinning nozzle block comprising: an internal space for accommodating a spinning solution transferred and injected from a solution storage tank; a nozzle body including a plurality of solution distribution ports; an electrospinning nozzle including an airflow jetting means; a nozzle adapter for detachably connecting the electrospinning nozzle to the nozzle body; and a high voltage applying means for applying high voltage electricity from a high voltage generator to the spinning solution accommodated in the internal space of the nozzle body, The electrospinning nozzle comprises: an internal nozzle body into which a first fluid is injected; an inner needle portion connected to the inner nozzle portion body and including a hollow tubular inner needle that is an outlet for the first fluid; an external nozzle body into which the second fluid is injected; an outer needle portion including a hollow tubular outer needle that is connected to the outer nozzle portion body and that is an outlet for the second fluid and that is arranged so as to coaxially surround the inner needle; an outer needle position adjusting unit that adjusts the position of the central axis of the outer needle; a gas inlet for injecting air, which is a gas; a gas ejection means coupled to an end of the outer needle position adjusting part, for generating a straight air flow surrounding the spun filament discharged from the double needle consisting of an outer needle coaxially surrounding the inner needle at a distance from the discharge port, the gas ejection means includes a central hole through which the double needle passes, and a plurality of gas ejection ports arranged radially around the central hole at a predetermined distance apart, The high voltage applying means a highly conductive high voltage application needle that corresponds one-to-one to the electrospinning nozzle; a high voltage body that fixes and arranges the high voltage application needle in the width direction, The nozzle body has a plurality of holes through which the high voltage application needle passes, the holes being formed on the opposite side to the coupling side of the electrospinning nozzle.

14. The external needle position adjustment unit a cylindrical position adjustment unit body that is disposed between the external needle portion and the gas ejection means and forms a gas flow path; The electrospinning nozzle block according to claim 13 , further comprising: a plurality of screw pins provided in a portion of the position adjustment part body for adjusting the central axis of the outer needle.

15. The gas inlet is formed at one end of the position adjustment unit body, The electrospinning nozzle block according to claim 14 , wherein the air injected through the gas inlet is discharged to the gas ejection means.

16. The electrospinning nozzle block according to claim 15, wherein the plurality of screw pins are arranged around the outer needle at a certain angular interval around a portion of the position adjustment portion body.

17. The inner diameter of the outer needle is configured to be 5 μm to 1000 μm larger than the outer diameter of the inner needle; 17. The electrospinning nozzle block of claim 16, wherein the distance between the central axis of the inner needle and the central axis of the outer needle is within 0.1 mm.

18. 17. The electrospinning nozzle block of claim 16, wherein the gas outlet comprises a plurality of air holes, at least two of which are arranged at regular intervals in a plurality of circumferential regions formed by at least one row of circular lines around the central hole, and which discharge the second fluid, air, to the outside.

19. The gas outlet is The radius r from the central hole １ a first gas outlet in which at least two air holes are arranged in a first circumferential region, which is a first circular line surrounding the central hole and spaced apart by a distance of The radius r from the central hole ２ a second gas outlet in which at least two air holes are arranged in a second circumferential region that is a second circular line surrounding the central hole and spaced apart by a distance of The radius r of the second circumferential region ２ is the radius r of the first circumferential region １ 20. The electrospinning nozzle block of claim 18, wherein the nozzle block is greater than

20. a plurality of n-th circumferential regions are further disposed outside the second circumferential region and surrounding the second circumferential region, where n is a natural number equal to or greater than 3; 20. The electrospinning nozzle block of claim 19, wherein at least two air holes are arranged in the nth circumferential region.

21. 21. The electrospinning nozzle block of claim 20, wherein six air holes are arranged at an angle of 60° to each other in the first circumferential region, the second circumferential region, and the nth circumferential region.

22. The gas ejection means is a side fastening part coupled to an end extending from the external needle position adjusting part; and a cover part having the central hole and a plurality of gas discharge ports arranged to surround the central hole, The electrospinning nozzle block according to claim 21 , which is an air cap in which the air retention space is formed by the side fastening portion and the cover portion.

23. The high voltage application needle further includes a hollow tubular guide needle for guiding the high voltage application needle so that the high voltage application needle can stably enter the hole, 23. The electrospinning nozzle block of claim 22, wherein the guide needle is disposed between the high voltage body and the nozzle body, and the inner diameter of the guide needle is larger than the diameter of the high voltage application needle.

24. 23. The electrospinning nozzle block of claim 22, wherein the high-voltage application needle is coaxially arranged inside the inner needle of the electrospinning nozzle or coaxially arranged inside the solution storage space of the inner nozzle body.

25. An electrospinning nozzle block comprising: an internal space for accommodating a spinning solution transferred and injected from a solution storage tank; a nozzle body including a plurality of solution distribution ports; an electrospinning nozzle including an airflow jetting means; a nozzle adapter for detachably connecting the electrospinning nozzle to the nozzle body; and a high voltage applying means for applying high voltage electricity from a high voltage generator to the spinning solution accommodated in the internal space of the nozzle body, The electrospinning nozzle comprises: an inner nozzle portion body including a first fluid inlet through which a first fluid is injected; an inner needle portion connected to the inner nozzle portion body and including a hollow tubular inner needle that is an outlet for the first fluid; an external nozzle body including a second fluid inlet through which air, which is a second fluid, is injected; an air pressure control unit body including a needle shaft for controlling and blocking the flow of the first fluid transferred to the internal needle portion, and a needle shaft sealing portion for preventing the first fluid from flowing back and leaking above the needle shaft; a gas ejection means coupled to an end of the outer nozzle body, for generating a stream of air, the second fluid, which moves straight while surrounding the spun filament discharged from the inner needle at a distance from the discharge port, the gas ejection means includes a central hole through which the internal needle passes, and a plurality of gas ejection ports arranged radially around the central hole at a predetermined distance apart, The high voltage applying means a highly conductive high voltage application needle that corresponds one-to-one to the electrospinning nozzle; a high voltage body that fixes and arranges the high voltage application needle in the width direction, The nozzle body has a plurality of holes through which the high voltage application needle passes, the holes being formed on the opposite side to the coupling side of the electrospinning nozzle.

26. the air pressure control unit body further includes an air inlet for injecting air into the needle shaft; The needle shaft a spring wound around the needle shaft and having an elastic restoring force; a tapered blocking portion formed at the distal end of the needle shaft for blocking a fluid passage toward the internal needle portion and thereby blocking the flow of the first fluid; 26. The electrospinning nozzle block of claim 25, comprising: a pointed-ended shaft needle connected to the tapered interruption and extending through the inner needle and protruding from its tip.

27. 27. The electrospinning nozzle block of claim 26, wherein the gas outlet comprises a plurality of air holes, at least two of which are arranged at regular intervals in a plurality of circumferential regions formed by at least one row of circular lines around the central hole, and which discharge the second fluid, air, to the outside.

28. The gas outlet is The radius r from the central hole １ a first gas outlet in which at least two air holes are arranged in a first circumferential region, which is a first circular line surrounding the central hole and spaced apart by a distance of The radius r from the central hole ２ a second gas outlet in which at least two air holes are arranged in a second circumferential region that is a second circular line surrounding the central hole and spaced apart by a distance of The radius r of the second circumferential region ２ is the radius r of the first circumferential region １ 28. The electrospinning nozzle block of claim 27, wherein the electrospinning nozzle block is greater than

29. a plurality of n-th circumferential regions are further disposed outside the second circumferential region and surrounding the second circumferential region, where n is a natural number equal to or greater than 3; 29. The electrospinning nozzle block of claim 28, wherein at least two air holes are arranged in the nth circumferential region.

30. 30. The electrospinning nozzle block of claim 29, wherein six air holes are arranged at an angle of 60° to each other in the first circumferential region, the second circumferential region, and the nth circumferential region.

31. The gas ejection means is a side fastening part coupled to an end extending from the external nozzle part body; and a cover part having the central hole and a plurality of gas discharge ports arranged to surround the central hole, The electrospinning nozzle block of claim 30, wherein the side fastening portion and the cover portion form an air cap inside which a retaining space for the second fluid, i.e., air, is formed.

32. The high voltage application needle further includes a hollow tubular guide needle for guiding the high voltage application needle so that the high voltage application needle can stably enter the hole, 32. The electrospinning nozzle block of claim 31, wherein the guide needle is disposed between the high voltage body and the nozzle body, and the inner diameter of the guide needle is larger than the diameter of the high voltage application needle.

33. 32. The electrospinning nozzle block of claim 31, wherein the high voltage application needle is coaxially arranged inside the inner needle of the electrospinning nozzle or coaxially arranged inside the solution storage space of the inner nozzle body.

34. an unwinding unit that unwinds a roll around which a substrate is wound to spin the spinning solution and laminate the nanofibers; a winding unit that winds the substrate on which the nanofibers are laminated; At least one nozzle block array formed by connecting at least one electrospinning nozzle block according to any one of claims 1 to 33 in the width direction of the substrate; a collector for depositing nanofibers spun from at least one of the nozzle block arrays while transporting the substrate; a solution storage tank for storing a spinning solution; a solution transfer device for transferring the spinning solution from the solution storage tank to the spinning nozzle of the modular electrospinning nozzle block; a high-voltage power supply for applying a high DC voltage to the spinning solution.

35. a robot driving unit for driving the nozzle block array back and forth along the width direction of the substrate; a spinning distance adjusting unit that moves the nozzle block array up and down to adjust the distance between the collector and the tip of the spinning needle; 35. The electrospinning apparatus of claim 34, further comprising: stacking guide units arranged on the left and right sides of the nozzle block array in the direction in which the substrate is transported, for stacking the spun nanofibers in a limited area of ​​the collector.

36. a hot air generator for producing fine nanofibers by volatilizing a solvent from a large amount of spun filaments spun from the spinning needles of the nozzle block array; a humidity control device for controlling the evaporation rate of the solvent by controlling the internal humidity of the electrospinning device; The electrospinning apparatus of claim 35, further comprising a laminating device for adjusting the bonding state of the nanofibers laminated on the substrate.

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