Multi-chamber container

The multi-chamber container design ensures reliable opening and mixing of drugs by using a weak seal and shaped middle seals to transmit pressure effectively, addressing issues of incomplete mixing and drug quality maintenance.

JP2026026285APending Publication Date: 2026-02-16OTSUKA PHARMACEUTICAL FACTORY INC
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Patent Information

Application Number
JP2025225424
Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
Filing Date
2025-12-03
Publication Date
2026-02-16

AI Technical Summary

Technical Problem

Existing multi-chamber medical containers face issues with unreliable opening of small containers due to insufficient or improperly applied external forces, leading to incomplete mixing of drugs stored in separate compartments.

Method used

A multi-chamber container design featuring a small container within a container body, with a weak seal portion that peels off under increased pressure, and two middle seal portions with specific shapes and strengths to ensure reliable opening, even with weak external forces or incorrect application positions.

Benefits of technology

The design allows for reliable opening of the small container and mixing of contents with the storage section drugs, maintaining drug quality and ease of use, even with varying force application strengths and positions.

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Abstract

To provide a multi-chamber container in which a small container can be surely unsealed without affecting the easy peelability of a weak seal part for sealing a part of the small container in the multi-chamber container storing the small container in a container body.SOLUTION: The multi-chamber container includes a container body having a plurality of storage parts, and a small container arranged in one of the plurality of storage parts and formed in a bag shape by two laminated films, and the storage part and the small container are opened and communicated with each other by increasing pressure in the storage part. A multi-chamber container comprising: a weak seal part that seals a part of a small container, is not bonded to a container body, and is peeled off by increasing a pressure in a storage part; and a bonded part that bonds two films forming the small container to each other and to the container body at a position other than the weak seal part, and is bonded so that the two films are peeled off by increasing the pressure in the storage part.SELECTED DRAWING: Figure 1
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Description

[Technical Field]

[0001] The present invention relates to a multi-chamber container. [Background technology]

[0002] Some drugs administered intravenously to patients are unstable and undergo undesirable changes over time when mixed together. For example, when an amino acid infusion solution and a glucose infusion solution are mixed and stored, the mixture turns brown due to the Maillard reaction. Furthermore, when a fat emulsion and an electrolyte solution are mixed and stored, the fat content aggregates, and when a phosphate-containing solution and a calcium-containing solution are mixed, calcium phosphate precipitates, causing undesirable changes.

[0003] For such medicines, multi-chamber medical containers that individually store the components before mixing are often used. These multi-chamber medical containers have multiple storage sections that individually store the medicines and weak partition seals that separate the storage sections and can be peeled off by applying pressure from the outside (see, for example, Patent Document 1). [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Japanese Patent Application Laid-Open No. 2002-136570 [Patent Document 2] International Publication No. 03 / 092574 Summary of the Invention [Problem to be solved by the invention]

[0005] 8 to 10 are explanatory views showing an example of such a multi-chamber medical container according to a reference example, in which FIG. 8 is a plan view, FIG. 9 is a cross-sectional view taken along line XX in FIG. 8, and FIG. 10 is a cross-sectional view when opened.

[0006] As shown in Fig. 8, the multi-chamber container 1 has a rectangular container body 5 with its periphery 3 bonded together, and the interior of the container body 5 is divided by a partition 13 into a first storage section 9 and a second storage section 11, and each storage section 9, 11 contains various drugs a, b that are undesirable if mixed or dissolved in advance. Furthermore, a small container 15 is provided in one of the storage sections 9, 11 (first storage section 9 in Fig. 8), and drug c is stored in the small container 15. As shown in the enlarged cross section of Fig. 9, this small container 15 has an adhesive section 21 on the inner surface of films 15a, 15b of the small container 15, which is inside the films 5a, 5b that make up the container body 5. As shown in Figure 10, when a force is applied from the outside of the container body 5, pressure is applied to the partition 13 to apply peeling forces F, F, opening the first storage section 9 and the second storage section 11 and mixing the drugs a and b, the adhesive section 21 of the small container 15 also peels off at the same time, and the drug c in the small container 15 also mixes with the drugs a and b in each storage section 9, 11 (see, for example, Patent Document 2).

[0007] However, if the pressure and peeling forces F, F on the partition 13 are insufficient, for example, because the external force on the multi-chamber container is not strong enough or the position at which the force is applied is inappropriate, the adhesive portion 21 of the small container 15 may not peel off, and the drug c in the small container 15 may not mix with the drugs a, b in each storage section 9, 11.

[0008] In order to solve the above-mentioned problems, the present invention aims to provide a multi-chamber container that stores a small container inside the container body, and that allows the small container to be opened reliably without affecting the ease of peeling of the weak seal portion that seals part of the small container. [Means for solving the problem]

[0009] The present invention is a multi-chamber container comprising a container body having a plurality of storage compartments, and a small container that is placed in one of the plurality of storage compartments and is formed into a bag shape from two laminated films, wherein the storage compartments and the small container can be opened and connected to each other by increasing the pressure inside the storage compartment, and the multi-chamber container comprises a weak seal portion that seals a portion of the small container, is not adhered to the container body, and peels off when the pressure inside the storage compartment is increased, and an adhesive portion that bonds the two films that form the small container together and the container body, and is bonded so that the adhesion between the two films peels off when the pressure inside the storage compartment is increased.

[0010] The present invention also provides a multi-chamber container comprising a container body having a plurality of storage sections, and a small container formed into a bag shape by two laminated films and placed in one of the plurality of storage sections, wherein the storage section and the small container can be opened and connected to each other by increasing the pressure inside the storage section, the container comprising: a weak seal section that seals a portion of the small container, is not adhered to the container body, and peels when the pressure inside the storage section is increased; an adhesive section that bonds the two films forming the small container and the container body together at a position other than the weak seal section, and is bonded so that the adhesion between the two films peels when the pressure inside the storage section is increased; a first middle seal section that has a seal strength higher than that of the weak seal section; and a second middle seal section that has a seal strength higher than that of the weak seal section. the first middle seal portion and the second middle seal portion are arranged opposite each other, the weak seal portion is arranged along the adhesive portion, and the adhesive portion is arranged along the portion sandwiched between the first middle seal portion and the second middle seal portion, the first middle seal portion and the second middle seal portion are inclined so that the sandwiched portion becomes narrower as it approaches the adhesive portion so that pressure and peeling force within the storage portion are transmitted to the adhesive portion and the weak seal portion, causing the adhesive portion and the weak seal portion to peel off, and the distance from the tip of the first middle seal portion to the adhesive portion in the sandwiched portion is shorter than the longitudinal length of the first middle seal portion, and the distance from the tip of the second middle seal portion to the adhesive portion in the sandwiched portion is shorter than the longitudinal length of the second middle seal portion.

[0011] The container body may be provided with a partition weak seal portion that separates the multiple storage sections and that can be opened and connected by increasing the pressure within the storage sections, the adhesive portion being arranged between the weak seal portion and the partition weak seal portion, and the first middle seal portion and the second middle seal portion being arranged to overlap a portion of the partition weak seal portion.

[0012] In addition, the multi-chamber container of the present invention further comprises a first middle seal portion having a higher seal strength than the weak seal portion, and a second middle seal portion having a higher seal strength than the weak seal portion, the first middle seal portion and the second middle seal portion being arranged opposite each other, and the first middle seal portion and the second middle seal portion may be inclined so that the pressure and peeling force within the storage portion are transmitted to the weak seal portion, causing it to peel off.

[0013] Furthermore, the first middle seal portion of the present invention has one end that is close to the peripheral edge of the container body having multiple storage compartments and a tip portion that is the opposite end, and the second middle seal portion has one end that is close to the peripheral edge of the container body and a tip portion that is the opposite end, the area between the tip portion of the first middle seal portion and the tip portion of the second middle seal portion is provided along the weak seal portion, the distance from the tip portion of the first middle seal portion to the weak seal portion is shorter than the distance from one end of the first middle seal portion to the tip of the first middle seal portion, and the distance from the tip portion of the second middle seal portion to the weak seal portion is shorter than the distance from one end of the second middle seal portion to the tip of the second middle seal portion, the first middle seal portion and the second middle seal portion have inclined portions so that the distance between them becomes narrower the closer they are to the weak seal portion that is the tip end side of each other, and the inclined portions of the first middle seal portion and the second middle seal portion are configured so that the pressure and peeling force within the storage compartments are transmitted to the weak seal portion, causing the weak seal portion to peel off.

[0014] In addition, in order to solve the above-mentioned problems, the present invention also aims to provide a multi-chamber container in which a small container is stored within the container body, and in which the storage section on the container body and the small container can be easily opened even if the external force applied to the multi-chamber container is not strong enough or the position at which the force is applied is not appropriate.

[0015] As a result of extensive research into the structure of multi-chamber containers, the present inventors have discovered a multi-chamber container that can solve the above-mentioned problems by providing two middle seal portions with specific shapes. For example, the present invention provides a multi-chamber container comprising a plurality of storage sections, a small container arranged adjacent to one of the plurality of storage sections and having a smaller volume than the adjacent storage section, and a container body having the plurality of storage sections and the small containers, wherein the storage sections and the small containers can be opened and connected to each other by increasing the pressure inside the storage sections, and the container comprises a weak seal section that seals a part of the small container and is peeled off by increasing the pressure inside the storage sections, a first middle seal section having a seal strength higher than that of the weak seal section, and a second middle seal section having a seal strength higher than that of the weak seal section, the small container is rectangular with long sides facing the adjacent storage sections, the weak seal section is provided on the long sides, the first middle seal section and the second middle seal section are arranged opposite each other, and the first middle seal section has one end close to the periphery of the container body having the plurality of storage sections and a tip end which is the opposite end. the second middle seal portion has one end close to the peripheral edge of the container body and a tip portion which is the opposite end, the area between the tip portion of the first middle seal portion and the tip portion of the second middle seal portion is provided along the weak seal portion, the distance from the tip portion of the first middle seal portion to the weak seal portion is shorter than the distance from one end of the first middle seal portion to the tip of the first middle seal portion, and the distance from the tip portion of the second middle seal portion to the weak seal portion is shorter than the distance from one end of the second middle seal portion to the tip of the second middle seal portion, the first middle seal portion and the second middle seal portion have sloped portions so that the distance between them becomes narrower the closer they are to the weak seal portion which is the tip end side of each other, and the sloped portions of the first middle seal portion and the second middle seal portion allow the pressure and peeling force within the storage portion to be transmitted to the weak seal portion, causing the weak seal portion to peel off.

[0016] According to the present invention, in a multi-chamber container that stores a small container within the container body, even if the external force applied to the multi-chamber container is not strong enough or the position at which the force is applied is not appropriate, the storage section on the container body and the small container can be easily opened.

[0017] For example, the present invention is a multi-chamber container comprising a plurality of storage sections, a discharge port connected to one of the plurality of storage sections, and a small container provided within one of the plurality of storage sections, wherein the plurality of storage sections and the small container are opened and connected to each other by increasing the pressure within the storage sections, and the multi-chamber container comprises a weak seal section that seals a portion of the small container and is peeled off by increasing the pressure within the storage sections, a first middle seal section that has a seal strength higher than that of the weak seal section, and a second middle seal section that has a seal strength higher than that of the weak seal section, the first middle seal section and the second middle seal section are arranged opposite each other, the tip of the first middle seal section facing the second middle seal section and the tip of the second middle seal section facing the first middle seal section are close to the weak seal section, and the first middle seal section and the second middle seal section have inclined portions so that the distance between them becomes narrower the closer they are to the weak seal section.

[0018] In the multi-chamber container of the present invention, the leading edge of the first inner seal and the leading edge of the second inner seal are close to the weak seal, and the first inner seal and the second inner seal have sloped portions such that the distance between them becomes narrower the closer they are to the weak seal. This makes it easier for the pressure and peeling forces F, F to be transmitted to the weak seal, making it easier for the weak seal of the small container to peel, and for the contents of the small container to mix with the contents of each storage section, even when the external force is not strong or is applied in an incorrect position.

[0019] The weak seal portion of the present invention may be disposed on an extension line connecting the discharge port and a space between the first and second middle seal portions.

[0020] The first middle seal portion of the present invention has one end portion close to the peripheral edge of the multi-chamber container and a tip portion which is the opposite end, and the second middle seal portion has one end portion close to the peripheral edge of the multi-chamber container and a tip portion which is the opposite end, and the distance from the tip portion of the first middle seal portion to the weak seal portion may be shorter than the distance from one end of the first middle seal portion to the tip portion, and the distance from the tip portion of the second middle seal portion to the weak seal portion may be shorter than the distance from one end of the second middle seal portion to the tip portion.

[0021] The weak seal portion of the present invention may seal the small container without being adhered to the container body.

[0022] In the present invention, an adhesive part for adhering the small container to the container body may be provided on the inside of the small container outside the weak seal part.

[0023] The adhesive portion may be provided opposite the weak seal portion.

[0024] In addition, a multi-chamber container can also be provided that includes a container body having a plurality of storage compartments, a discharge outlet connected to the storage compartments, weak partition seals that separate the storage compartments and that are opened and connected to each other by increasing the pressure within the storage compartments, and a small container provided within one of the storage compartments, wherein the weak seal seal seals the small container and is opened together with the opening and connection of the weak partition seal seal, a first middle seal seal that has a higher seal strength than the weak partition seal seal, and a second middle seal seal that has a higher seal strength than the weak partition seal seal, wherein at least a portion of the weak partition seal seal is provided within the space between the first middle seal seal and the second middle seal seal, and the weak seal seal is provided opposite the weak partition seal seal provided within the space, and the tip end of the first middle seal seal on the space side and the tip end of the second middle seal seal on the space side are close to the weak seal seal.

[0025] In this multi-chamber container, at least a portion of the partitioning weak seal portion is provided within the space between the first and second inner seal portions, and the weak seal portion is provided opposite the partitioning weak seal portion provided within that space. This makes it easier for the pressure and peeling forces F, F to be transmitted to the partitioning weak seal portion, making it easier for the weak seal portion of the small container to peel, and facilitating mixing of the contents of the small container with the contents of each storage portion, even when the external force is not strong or is applied from an incorrect position.

[0026] This multi-chamber container may further comprise an adhesive portion that bonds the small container and the container body and that is opened together with the opening and communication of the partitioning weak seal portion.

[0027] In this multi-chamber container, the adhesive portion may be provided along the weak seal portion between the partitioning weak seal portion and the weak seal portion.

[0028] In this multi-chamber container, the first and second middle seal portions may be peelable.

[0029] In this multi-chamber container, the peripheral edge of the container body is bonded, and the seal strength of the first middle seal portion and the second middle seal portion may be lower than that of the peripheral edge portion.

[0030] In this multi-chamber container, the interval may be longer than half the width of the small container.

[0031] In this multi-chamber container, the distance from the tip of the first middle seal portion to the weak seal portion and the distance from the tip of the second middle seal portion to the weak seal portion may be smaller than the width in a direction perpendicular to the longitudinal direction of the partition weak seal portion.

[0032] Also, there is a multi-chamber container that includes a container body having a plurality of storage sections and a discharge port connected to the storage sections, and that divides the container body into a plurality of storage sections and that are opened and connected to each other by increasing the pressure inside the storage sections, and that has a partition weak seal section in one of the storage sections and that holds a small container that is opened when the partition weak seal section is opened and connected, and that has a first middle seal section that has a shape that is inclined toward the small container from one end side of the partition weak seal section to the center, and a second middle seal section that has a shape that is inclined toward the small container from the other end side of the partition weak seal section to the center, and The weak partition seal portion extends from one end to the other without intersecting with the first and second middle seal portions, and the first and second middle seal portions have a higher seal strength than the weak partition seal portion. The distance between the central tip of the first middle seal portion and the central tip of the second middle seal portion is shorter than the width of the small container, and at least a portion of the weak partition seal portion has a trapezoidal shape that narrows from the side away from the small container to the small container side, between the first and second middle seal portions.

[0033] In this multi-chamber container, at least a portion of the partitioning weak seal portion is provided with a first middle seal portion and a second middle seal portion having an inclined shape that provides greater seal strength and allows pressure and / or peeling force to be more easily transmitted to the small container. This makes it easier for the pressure and peeling force F, F to be transmitted to the partitioning weak seal portion, even when the external force is not strong or the force is applied in an off-center position, making it easier for the adhesive and weak seal portions of the small container to peel, and allowing the contents of the small container to mix with the contents of each storage portion.

[0034] In this multi-chamber container, the first and second inner seal portions may have symmetrical shapes, which makes it easier for the pressure and peeling forces F, F to be transmitted evenly to the partition weak seal portion and the small container.

[0035] In this multi-chamber container, the central tip ends of the first and second middle seal parts may have an angle of 10° or more and less than 90°. If the angle of the central tip ends of the first and second middle seal parts is in the range of 10° or more and less than 90°, the pressure and peeling forces F, F are more easily transmitted to the partition weak seal part and the small container.

[0036] It is preferable that the distance between the central tip of the first inner seal and the central tip of the second inner seal be shorter than the width of the small container and longer than half the width of the small container, which makes it easier to transmit pressure and peel forces F, F to the small container.

[0037] In this multi-chamber container, the maximum point load may be 250 N or more and 1800 N or less. When the maximum point load is in the above range, the multi-chamber container is easy to open and has good sealability during transportation, etc.

[0038] The opening strength of the partitioning weak seal may be 2.5 N / 15 mm or more and 4.5 N / 15 mm or less. When the opening strength of the partitioning weak seal is within this range, the resulting multi-chamber container is easy to open and has good airtightness during transportation, etc.

[0039] The multi-chamber container is preferably for medical or food use. Such a multi-chamber container that combines ease of opening with sealability during transportation can be used as a medical multi-chamber container and can also be used for food. [Effects of the Invention]

[0040] According to the present invention, in a multi-chamber container in which a small container is stored within a container body, the small container can be reliably opened without affecting the ease of peeling of the weak seal portion that seals a portion of the small container. [Brief explanation of the drawings]

[0041] [Figure 1] 1 is a plan view of a multi-chamber medical container according to one embodiment of the present invention. [Figure 2] FIG. 2 is an enlarged cross-sectional view of a portion of FIG. 1 taken along the line AA. [Figure 3] 1 is an enlarged cross-sectional view showing a peeled open state of a multi-chamber medical container according to one embodiment of the present invention. [Figure 4] FIG. 10 is a plan view of a multi-chamber medical container that is a modified example of the present embodiment. [Figure 5] FIG. 10 is a plan view of a multi-chamber medical container that is a modified example of the present embodiment. [Figure 6] FIG. 10 is a plan view of a multi-chamber medical container that is a modified example of the present embodiment. [Figure 7] FIG. 10 is a plan view of a multi-chamber medical container that is a modified example of the present embodiment. [Figure 8] FIG. 10 is a plan view of a multi-chamber container according to a reference example. [Figure 9] FIG. 9 is an enlarged cross-sectional view of a portion of FIG. 8 taken along the line XX. [Figure 10] 9 is a cross-sectional view showing the multi-chamber container shown in FIG. 8 in a peeled open state. DETAILED DESCRIPTION OF THE INVENTION

[0042] DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, an embodiment of a multi-chamber container according to the present invention will be described with reference to the drawings. The multi-chamber container of this embodiment comprises a container body having multiple storage sections and a discharge outlet connected to the storage sections, and is a multi-chamber container in which the container body is divided into multiple storage sections and weak partition seal sections that can be opened and connected to each other by increasing the pressure within the storage sections, and a small container is provided in one of the storage sections that can be opened together with the opening and connection of the weak partition seal section.

[0043] FIG. 1 is a plan view of a multi-chamber medical container according to an embodiment of the present invention, and FIG. 2 is an enlarged cross-sectional view taken along line AA in FIG.

[0044] As shown in Figure 1, the multi-chamber medical container 1 includes a container body 5 formed in a rectangular shape with a peripheral edge 3 bonded together, and a drug outlet 7 connected to the container body 5 and equipped with a rubber stopper for discharging the drug. The container body 5 has a first storage section 9 and a second storage section 11 arranged side by side in the longitudinal direction, and the two storage sections 9, 11 are separated by a peelable weak seal section 13 for separating them. The first storage section 9 and the second storage section 11 each contain various drugs a and b, which should not be mixed or dissolved in advance.

[0045] The multi-chamber medical container 1 can be a bag-like container formed by heat-sealing or gluing the peripheral edges of two single-layer or multi-layer films. The material constituting the container body 5 of the multi-chamber medical container 1 can be a film made of various resins, such as thermoplastic resins such as polyethylene, polypropylene, and polystyrene.

[0046] In order to adjust the pressure required to peel off the partition weak seal 13, for example, when melt-bonding a film made of a thermoplastic resin, the heat-bonding time for the partition weak seal 13 can be made shorter than the heat-bonding time for the peripheral edge 3 of the container body 5. Alternatively, the adhesive strength can be adjusted by applying a lower adhesive pressure to the partition weak seal 13 than to the peripheral edge 3 of the container body 5.

[0047] The first storage section 9 of the multi-chamber medical container 1 is provided with a small container 15 for storing a drug c, and the seal section for sealing the small container 15 is a weak seal section 21.

[0048] The adhesive portion 19 of the small container 15 to the container body 5 may be formed on the extensions 23a, 23b of the films 15a, 15b constituting the small container 15 outside the weak seal portion 21, as shown in the figure. The extensions 23a, 23b may be bonded in a continuous line over almost the entire length. Suitable bonding methods include, for example, heat sealing.

[0049] The width B (see FIG. 2) of the extensions 23a, 23b need only be wide enough to allow the small container 15 to adhere to the films 5a, 5b that make up the container body 5, and is specifically 3 to 20 mm, more preferably 5 to 15 mm. The width of the extensions 23a, 23b in FIG. 1 may be the same as the width of the weak seal portion 21.

[0050] The small container 15 is preferably a three-layer film with an inner layer of polyethylene, a middle layer of polycyclic olefin, and an outer layer of polyethylene, with films 15a and 15b having an easily peelable structure. The two overlapping films 15a and 15b are heat-sealed together to form a bag-like container. The pressure required to peel the weak seal 21 of the small container 15 can be adjusted by shortening the heat-sealing time for the weak seal 21 compared to the heat-sealing time for the other peripheral portions of the small container 15, as in the case of sealing the partition weak seal 13 of the container body 5 with the peripheral portion 3. Alternatively, the adhesive pressure for the weak seal 21 can be adjusted to a lower pressure than the adhesive pressure for the peripheral portion of the small container 15.

[0051] Fig. 2 is an enlarged cross-sectional view taken along line AA in Fig. 1. Fig. 3 is an enlarged cross-sectional view showing the peeled-open state of the multi-chamber medical container 1 according to one embodiment of the present invention. When using the multi-chamber medical container 1, a force is applied to the container body 5 (e.g., a part of the second storage section 11) in the direction of arrows F, F as shown in Fig. 2, peeling the partitioning weak seal section 13 and opening the first storage section 9 and the second storage section 11. Furthermore, as shown in Fig. 3, the opening of the small container 15 is pulled from the extensions 23a, 23b to the films 5a, 5b of the container body 5, and the peeling force is transmitted to the weak seal section 21, peeling it open as shown in Fig. 3, allowing the drug c inside to flow out.

[0052] At this time, the adhesive portion 19 is located at a position other than the weak seal portion 21, so that in the case of, for example, thermal melt adhesion, the heat does not affect the ease of peeling of the weak seal portion 21, making it possible to reliably open the package as shown in Figure 3. Furthermore, because the adhesive portion 19 is located on the outside of the small container 15, the drug c inside is not affected by the heat generated during melt adhesion, and the quality of the drug c inside can be maintained at a good level.

[0053] In the multi-chamber medical container 1 of this embodiment, a first middle seal L1 is formed, which has a shape that slopes toward the small container 15 from one end of the partitioning weak seal 13 toward the center. A second middle seal R1 is also formed, which has a shape that slopes toward the small container 15 from the other end of the partitioning weak seal 13 toward the center. The first middle seal L1 and the second middle seal R1 do not intersect with each other. The shapes of the first middle seal L1 and the second middle seal R1 are not particularly limited as long as they slope toward the small container 15 from one end of the partitioning weak seal 13 toward the center and do not intersect with each other. For example, as shown in FIG. 1, the first middle seal L1 may be triangular with three sides p1, q1, and r1. The second middle seal R1 may also be triangular like the first middle seal L1. In the first middle seal L1 in FIG. 1, side q1 indicates the inclination of the inclined shape. The inclined shape is not limited to a straight line like the side q1 in FIG. 1, but may be, for example, an arc shape. By forming the first middle seal L1 and the second middle seal R1 in this way, the partition weak seal 13 has a trapezoidal shape that narrows from the second storage section 11 side toward the small container 15 side. As a result, for example, when a load is applied to a part of the second storage section 11, pressure and peeling forces F, F are easily transmitted from the second storage section 11 side to the partition weak seal 13 and the small container 15 side, making it easier to peel the adhesive section 19 and the weak seal 21 of the small container 15. As a result, the drug c in the small container 15 is more likely to mix with the drugs a, b in the storage sections 9, 11. Note that in this embodiment, the middle seal refers to a seal with stronger sealing strength than the weak seal.

[0054] In the multi-chamber medical container 1 of this embodiment, the shape of the first middle seal portion L1 and the shape of the second middle seal portion R1 may be asymmetric, but are preferably symmetrical to each other. If the shape of the first middle seal portion L1 and the shape of the second middle seal portion R1 are symmetrical to each other, the pressure and peeling forces F, F to the partition weak seal portion 13 and the small container 15 are more likely to be transmitted uniformly from the inclined shape of the first middle seal portion L1 and the inclined shape of the second middle seal portion R1.

[0055] Furthermore, in the multi-chamber medical container 1 of this embodiment, the central tip X of the first middle seal portion L1 and the central tip Y of the second middle seal portion R1 may have an angle of 10° or more and less than 90°. If the angle between the central tip X of the first middle seal portion L1 and the central tip Y of the second middle seal portion R1 is in the range of 10° or more and less than 90°, the pressure and peeling forces F, F are more easily transmitted to the partition weak seal portion 13 and the small container 15.

[0056] The angle between the central tip X of the first middle seal part L1 and the central tip Y of the second middle seal part R1 is more preferably in the range of 10 to 80°, even more preferably in the range of 50 to 80°, and particularly preferably in the range of 60 to 70°.

[0057] The distance between the central tip X of the first middle seal portion L1 and the central tip Y of the second middle seal portion R1 is preferably shorter than the width of the small container 15, and is preferably longer than half the width of the small container 15. This makes it easier to transmit pressure and peeling forces F, F to the small container 15.

[0058] Furthermore, it is preferable that the center of the gap between the central tip X of the first middle seal portion L1 and the central tip Y of the second middle seal portion R1 coincides on a line perpendicular to the width of the partition weak seal portion 13. It is particularly preferable that the center of the gap coincides with the center of the width of the partition weak seal portion 13.

[0059] In the multi-chamber medical container 1 of this embodiment, the maximum point load during the process of increasing the pressure inside the storage section (second storage section 11) is preferably 250 N or more and 1800 N or less. If the maximum point load is within this range, medical personnel can adequately open the weak partition seal 13 and the small container 15 of the multi-chamber medical container 1 with an appropriate amount of force. The maximum point load (maximum point load value) is the maximum load value when gradually applying force to the second storage section 11 of the multi-chamber medical container 1. This value increases for a certain period of time when force is applied, peaks just before the weak partition seal 13 or the adhesive section 19 and weak seal 21 of the small container 15 open, and then drops sharply after opening. If the maximum point load value is designed to be lower than 250 N, there is a risk that the weak partition seal 13 or the adhesive section 19 and weak seal 21 of the small container 15 will open unintentionally, for example, during transportation, or that the medical personnel will open them unintentionally. Furthermore, if the maximum point load is designed to be higher than 1800N, it may become difficult to increase the pressure inside the storage section, which is necessary to open the partition weak seal section 13 or the adhesive section 19 and weak seal section 21 of the small container 15. More preferably, the maximum point load is 300N or more and 1800N or less, and even more preferably, the maximum point load is 350N or more and 1600N or less.

[0060] The opening strength (N / 15mm) of the partition weak seal portion 13 is the force required to peel off a 15mm-wide piece of the partition weak seal portion 13, and may be lower than the opening strength of the first and second middle seal portions L1 and R1, i.e., 2.5N / 15mm or more and 4.5N / 15mm or less. If the opening strength is lower than 2.5N / 15mm, there is a risk that the partition weak seal portion 13 may be unintentionally opened, for example, during transportation. If the opening strength is higher than 4.5N / 15mm, there is a risk that it will be difficult to increase the pressure inside the storage compartment, which is necessary to open the partition weak seal portion 13 or the adhesive portion 19 and weak seal portion 21 of the small container 15.

[0061] Fig. 4 is a plan view of a multi-chamber medical container that is a modified example of this embodiment. As shown in Fig. 4, the central tip ends of the first middle seal portion L2 and the second middle seal portion R2 do not have to be acute angles like X and Y in Fig. 1, but the first middle seal portion L2 or the second middle seal portion R2 may be trapezoidal, with the central tip end being a side like S2. Here, when the central tip end forms a side rather than an acute angle as in Fig. 4, for example, in the first middle seal portion L2, the angle between side S2 and side q2 may be subtracted by 90°, the right angle, to obtain a preferred angle, as in the embodiment of Fig. 1.

[0062] FIG. 5 is a plan view of a multi-chamber medical container according to a modified example of this embodiment. As shown in FIG. 5, the shape of the first middle seal L3 or the second middle seal R3 may extend beyond the partitioning weak seal 13, or may overlap a portion of the peripheral edge 3 of the container body 5 or a portion of the second storage section 11. Furthermore, the shape of the first middle seal L3 or the second middle seal R3 does not have to be triangular as in the embodiment of FIG. 1 , but may be, for example, a combination of a triangle or a trapezoid and a rectangle. The formation of the first middle seal L3 and the second middle seal R3 may result in at least a portion of the partitioning weak seal 13 narrowing into a trapezoidal shape from the second storage section 11 side toward the small container 15 side.

[0063] 6 and 7 are plan views of a multi-chamber medical container according to a modified example of this embodiment. As shown in FIGS. 6 and 7, the shape of the first middle seal L4 or the second middle seal R4 (the first middle seal L5 or the second middle seal R5) may extend further beyond the partitioning weak seal 13 than in the embodiments shown in FIGS. 1, 4, and 5. A portion of the first middle seal L4 or the second middle seal R4 (the first middle seal L5 or the second middle seal R5) may overlap the peripheral edge 3 of the container body 5 or a portion of the second storage compartment 11, as long as the capacity of the second storage compartment 11 is not significantly reduced. Furthermore, the shape of the first middle seal L4 or the second middle seal R4 (the first middle seal L5 or the second middle seal R5) does not have to be triangular, as in the embodiment shown in FIG. 5, and may be, for example, a combination of a triangle, a trapezoid, and a rectangle.

[0064] The multi-chamber medical container 1 of this embodiment can be manufactured in the same manner as known multi-chamber medical containers. The first middle seal L or the second middle seal R can be formed, for example, by forming the partitioning weak seal 13 and then thermally bonding the desired portion of the first middle seal L or the second middle seal R at a higher temperature. Alternatively, after forming the partitioning weak seal 13, it is possible to create irregularities similar to the shape of the first middle seal L or the second middle seal R using an irregular mold, which will catch when opening the container and delay the opening. The aforementioned irregularities can also be caught by, for example, strongly vibrating and mixing the first storage section 9 and the second storage section 11, thereby completely opening the container.

[0065] Furthermore, in the multi-chamber medical container 1 of this embodiment, for example, a load can be applied to a portion of the second storage section 11, and pressure and peeling forces F, F can be transmitted from the second storage section 11 side to the partitioning weak seal 13 and small container 15 side, opening the first storage section 9, second storage section 11, and small container 15, and further, by applying a load to a portion of the first storage section 9, the partitioning weak seal 13, first middle seal L, and second middle seal R can be completely peeled off. This makes it possible to adjust the content volume of the second storage section 11 after opening so that it does not become smaller than before.

[0066] In the above embodiment, a multi-chamber medical container is described as an example, but this embodiment is not limited to medical use and may be, for example, a multi-chamber food container. In the case of a multi-chamber food container, the contents may be, for example, a fluid food, and the outlet serves as a food outlet for discharging the food out of the container. [Example]

[0067] Examples of the present invention will be described below, but the present invention is not limited to the following examples.

[0068] In this example, a first and second middle seal portion were provided in the partitioning weak seal portion of a multi-chamber medical container, and the maximum point load value was measured when an operation to increase the pressure inside the storage portion was carried out.

[0069] The maximum point load values ​​of the multi-chamber medical containers of Examples 1 to 3 were measured with a Tensilon (product name, manufactured by A&D Co., Ltd.) using a hand-pressing plate (170 mm×100 mm).

[0070] Example 1 The multi-chamber medical container used was Elneopa No. 2 (product name, manufactured by Otsuka Pharmaceutical Factory, Inc., capacity 1500 ml). The shapes of the first and second inner seals were the same as those shown in Figure 5 and Table 1. The opening strength of the partition weak seal 13 was 3.5 N / 15 mm. After forming the partition weak seal 13, the first inner seal L3 and second inner seal R3 were resealed to create a shape that would make the opening strength greater than that of the partition weak seal 13. The maximum point load when force was applied to the second storage section 11 of this container to perform the opening operation is shown in Table 1.

[0071] Example 2 The multi-chamber medical container used was Elneopa No. 2 (product name, manufactured by Otsuka Pharmaceutical Factory, Inc., capacity 1500 ml). The shapes of the first and second inner seals were the same as those shown in Figure 6 and Table 1. The opening strength of the partition weak seal 13 was 3.5 N / 15 mm. After forming the partition weak seal 13, the first inner seal L4 and second inner seal R4 were resealed to create a shape that was greater than the opening strength of the partition weak seal 13. The maximum point load when force was applied to the second storage section 11 of this container to perform the opening operation is shown in Table 1.

[0072] Example 3 The multi-chamber medical container used was Elneopa No. 2 (product name, manufactured by Otsuka Pharmaceutical Factory, Inc., capacity 1500 ml). The shapes of the first and second inner seals were the same as those shown in Figure 7 and Table 1. The opening strength of the partition weak seal 13 was 3.5 N / 15 mm. After forming the partition weak seal 13, the first inner seal L5 and second inner seal R5 were resealed to create a shape that was greater than the opening strength of the partition weak seal 13. The maximum point load when force was applied to the second storage section 11 of this container to perform the opening operation is shown in Table 1.

[0073] The angles and intervals of the middle seal portions of Examples 1 to 3, as well as the measurement results of the maximum point load when opened, are shown in Table 1 below.

[0074] [Table 1] [Explanation of symbols]

[0075] 1...multi-chamber medical container, 3...periphery, 5...container body, 7...discharge port, 9...first storage section, 11...second storage section, 15...small container, 19...adhesive section, 21...weak seal section, L, L1 to L5...first middle seal section, R, R1 to R5...second middle seal section, X...central tip of first middle seal section, Y...central tip of second middle seal section, q1...side (sloped shape).

Claims

[Claim 1] A multi-chamber container comprising: a container body having a plurality of storage sections; and a small container formed in a bag shape by two laminated films, the small container being disposed in any one of the plurality of storage sections; wherein the storage section and the small container are opened and communicated with each other by increasing the pressure within the storage section; a weak seal portion that seals a portion of the small container, is not adhered to the container body, and peels off when the pressure inside the storage portion is increased; A multi-chamber container is provided with an adhesive portion that bonds the two films forming the small container together and the container body, and that is bonded so that the adhesion between the two films can be peeled off by increasing the pressure inside the storage portion.

Citation Information

Patent Citations

  • Medical double-chamber container

    JP2002136570A

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    WO2003092574A1