Spectroscopic Light Pipes
A light pipe is used to improve spectroscopic analysis by aligning and spacing the spectrometer and sample, addressing scattering issues and enhancing measurement accuracy and efficiency.
Patent Information
- Application Number
- JP2022209338
- Authority / Receiving Office
- JP · JP
- Patent Type
- Patents
- Current Assignee / Owner
- Priority Date
- 2016-04-05
- Filing Date
- 2022-12-27
- Publication Date
- 2025-01-09
- Estimated Expiration
- 2037-04-05
AI Technical Summary
Existing spectroscopic methods face challenges in accurately and efficiently identifying the composition of samples due to light scattering and difficulty in spacing the spectrometer and sample for reliable measurements.
The use of a light pipe to align and space the spectrometer and sample, ensuring accurate optical measurements by directing light between the spectrometer and sample, reducing scattering, and improving alignment and spacing.
Enhances the accuracy and speed of spectroscopic analysis by minimizing light loss and scattering, reducing alignment difficulties, and optimizing sample-spectrometer spacing.
Smart Images

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Abstract
Description
[Background technology]
[0001] Raw material identification can be used for quality control of medicines, foods, etc. For example, raw material identification For pharmaceutical compounds, the ingredients of the pharmaceutical compound are associated with the packaging label of the pharmaceutical compound. It is possible to determine whether the product is consistent with the raw materials by non-destructive spectroscopic analysis. For example, spectroscopic analysis can be used to identify tablets sealed in a blister pack. The tablet or pill matches the blister pack packaging label. You can determine whether it is. Summary of the Invention [Means for solving the problem]
[0002] According to some possible embodiments, the spectroscopic assembly may include a spectrometer. The spectrometer may include an illumination source that generates light to illuminate the sample. The spectrometer may include a spectrometer that divides the light that illuminates the sample by reflecting it off the sample. The spectroscopic assembly may include a sensor that performs spectroscopic measurements based on light reflected from the sample. The light pipe may include a first opening that accommodates the spectrometer. The light pipe is arranged so that when the sample is accommodated in the second opening, the sample is held by the light pipe and the base surface. The light pipe may include a second opening for receiving a sample so as to be surrounded by the light pipe. It may be related to the alignment with the sample.
[0003] According to some possible embodiments, the device may include a body portion. The body portion may include a cavity. The cavity may extend axially from a first opening in the body to a second opening in the body. The second opening in the body may be associated with receiving a sample for spectroscopic analysis. The first opening is a specific distance away from the sample so that the spectrometer does not come into contact with the sample. It may be relevant to housing the spectrometer as such.
[0004] According to some possible embodiments, the apparatus may comprise a spectroscopic assembly. The spectrometer may include a spectrometer. The spectrometer may include an illumination source and a spectroscopic sensor. The light pipe may comprise a turned cavity. The light pipe may include a first opening that houses the spectrometer. The light pipe may include a second opening. The portion may include a protective window to prevent the sample from entering the turned cavity and coming into contact with the spectrometer. The cavity may be optically reflective. The spectroscopic assembly may include a support structure. The support structure may be optically reflective. The support structure can be attached to the surface at a specific distance from the radiation source. By providing a certain distance, the sample can be placed between the protective window and the surface. It can be done. [Brief description of the drawings]
[0005] [Figure 1] FIG. 1 is a schematic diagram of an exemplary embodiment described herein. [Diagram 2] FIG. 1 illustrates an example environment in which the systems and / or methods described herein may be implemented. [Diagram 3] FIG. 3 illustrates example components of one or more of the devices of FIG. 2. [Figure 4] 1 is a flow chart of an exemplary process for raw material identification using spectroscopy. [Figure 5A] FIG. 5 illustrates an exemplary embodiment of the exemplary process shown in FIG. 4. [Figure 5B] FIG. 5 illustrates an exemplary embodiment of the exemplary process shown in FIG. 4. [Figure 6A]FIG. 5 illustrates another exemplary embodiment of the exemplary process shown in FIG. [Figure 6B] FIG. 5 illustrates another exemplary embodiment of the exemplary process shown in FIG. [Figure 6C] FIG. 5 illustrates another exemplary embodiment of the exemplary process shown in FIG. [Figure 7A] FIG. 5 illustrates yet another exemplary embodiment of the exemplary process shown in FIG. [Figure 7B] FIG. 5 illustrates yet another exemplary embodiment of the exemplary process shown in FIG. [Figure 8A] FIG. 5 illustrates yet another exemplary embodiment of the exemplary process shown in FIG. [Figure 8B] FIG. 5 illustrates yet another exemplary embodiment of the exemplary process shown in FIG. [Figure 8C] FIG. 5 illustrates yet another exemplary embodiment of the exemplary process shown in FIG. [Figure 9A] FIG. 5 illustrates yet another exemplary embodiment of the exemplary process shown in FIG. [Figure 9B] FIG. 5 illustrates yet another exemplary embodiment of the exemplary process shown in FIG. [Figure 10] FIG. 5 illustrates yet another exemplary embodiment of the exemplary process shown in FIG. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
[0006] Exemplary embodiments are described in detail below with reference to the accompanying drawings, in which: The same reference numbers refer to the same components.
[0007] A raw material identification (RMID) is a method for identifying the components (e.g., constituents) of a particular sample for identification, verification, etc. For example, RMID is a method used to identify the ingredients of a drug. It can be used to verify that the ingredients listed on the label match the set of ingredients listed on the label. Spectrometers perform spectroscopic analysis of a sample (e.g., a pharmaceutical) to determine its components. The spectrometer can be used to perform a set of spectroscopic measurements of a sample and analyze the set of spectroscopic measurements. can be output for the class.
[0008] However, when the spectrometer directs light towards the sample, the light disperses, which can reduce the reliability of the measurement. Furthermore, it is difficult to obtain an ideal distance between the spectrometer and the sample for making measurements. The embodiments described herein direct light between a spectroscopic sensor of a spectrometer and a sample. To achieve this, a light pipe (e.g., a light conduit or a light relay) can be used. By improving the accuracy of light measurements, the light pipe can be used to perform spectroscopy without the need for a light pipe. It is possible to improve RMID. In addition, it is possible to ensure accurate alignment and spacing of the sample and the spectroscopic sensor. The use of light pipes allows for faster spectroscopic measurements based on a light pipe that retains the This can reduce the time and / or cost of verifying sample components compared to non-spectrometers. can.
[0009] FIG. 1 is a schematic diagram of an exemplary embodiment 100 described herein. As shown in FIG. The exemplary embodiment 100 may include a spectrometer 110, a light pipe 120, and a sample 130. FIG. 1 is a cross-sectional view of a spectrometer 110, a light pipe 120, and a sample 130.
[0010] As further shown in FIG. 1 at 140, attachment of the spectrometer 110 to the light pipe 120: The splitter 110 may be axially aligned with the cavity 140 of the light pipe 120. 120 may be turned (e.g., by diamond turning) to form cavity 140. (The body may be turned using a lathe procedure to create the turned cavity.) In some embodiments, In this case, the cross-sectional shape of the cavity 140 is determined based on the expected shape of the sample 130, the manufacturing process of the specific cross-section, Depending on the possibilities etc., it can be circular, oval, rectangular, octagonal, square, etc. The cavity 140 has a first portion having a first diameter 142 and a second portion having a second diameter 144. The cavity 140 may extend axially from a first opening 146 to a second opening 148. In some embodiments, the cavity 140 may have a reflective inner surface (e.g., aluminum The adhesive may have a Mite surface or an aluminized Mylar foil surface. The second portion of the cavity 140 extends axially a length 150, which is the same length as the spectrometer 110. Based on the expected ideal distance (or a specific distance range) between the spectroscopic sensor and the sample 130, In some embodiments, the light pipe 120 can be selected from a gold-based material. , a hollow light pipe coated with a reflective material such as a silver-based material, other metallic materials, or a dielectric material. In some embodiments, the light pipe 120 may be coated with a reflective material. For example, a portion of the cavity 140 may be depleted to a specific spectral region ( For example, zinc sulfide (ZnS) is optically transparent at infrared wavelengths, while quartz glass is optically transparent at ultraviolet wavelengths. The material may be a solid light-transmitting material such as glass or plastic. In some embodiments, the light pipe 120 is coated with a reflective material. Solid light pipes that are not reflective (e.g., those that are not reflective due to the total internal reflection effect (or related effects) It may also be a light pipe that directs threshold internal reflection (THR) between the spectrometer 110 and the sample.
[0011] As further shown in FIG. 1 at 155, the spectrometer 110 is attached to the light pipe 120. , the end of the spectrometer 110 can be inserted into the cavity 140 through an opening 146. For example, the end of the spectrometer 110 through which light is transmitted for spectroscopic measurement may be located at the end of the cavity 140. In another example, the light pipe 120 can be inserted into the first portion (e.g., a spectrometer). 110) to direct light to the sample 130 and The width (i.e., diameter 142) of the first portion can be The width of the two portions (i.e., diameter 144) can be made larger than that of the two portions. When the spectrometer 110 is inserted into the cavity 140 through the opening 146, the spectrometer 110 is aligned with the surface 1 52 (e.g., a mounting surface), and a length 150 (e.g., a length of 10 mm) from the sample 130 , 120 mm, etc. The cavity 140 may include a protective window (e.g., a semi-transparent window that prevents the spectrometer 110 from contacting the sample 130). For example, the cavity 140 may include a transparent sapphire glass window. A protective window (e.g., , with an anti-reflective coating, such as a single anti-reflective coating, a double anti-reflective coating, transparent and / or semi-transparent Thus, the light pipe 120 may include a single light pipe 120 (e.g., a single light pipe 120 and a cavity 140 is used to transmit the light toward the sample 130 and toward the spectrometer 110. In addition to transmitting light between the spectrometer 110 and the sample 130 (in both directions of receiving light), The end of the spectrometer 110 is protected from particles entering the opening 148 and is protected by a protective window. In another example, the maintenance costs can be reduced compared to a non-integrated spectrometer 110. The protective window reduces the amount of light passing through the mirror toward the spectrometer 110 (compared to, for example, using a window without a polarizer). The polarizer may include a circular polarizer portion (which reduces surface reflections).
[0012] As further shown in FIG. 1 at 160, the spectrometer 110 and the light pipe 120 ("assembly") When using the “Sample-Based 165” (referred to as “Sample-Based 165”), the sample 130 (e.g., pills in a blister pack) is opened and A second portion of the cavity 140 can be inserted through the mouth 148. For example, The surface 162 on which the sample 130 is placed is placed adjacent to the surface 164 of the light pipe 120. 30 placed sample containers 166 (e.g., blisters of transparent plastic or the like for encasing pills) The pack (part of the pack) is surrounded by a second part of the cavity 140. As shown by reference numeral 170 The light is then directed by a light pipe 120 between the end of the spectrometer 110 and a sample container 166 (e.g., , toward the sample 130. For example, the spectrometer 110 may A determination can be made and an RMID can be made based on the measurement.
[0013] As noted above, FIG. 1 is provided by way of example only. Other examples are possible and will be described with respect to FIG. For example, the embodiments may be described with respect to pill samples. However, the present disclosure is not limited to pill samples and may include other types such as granular, food, liquid, solvent, etc. A sample of the above can also be used.
[0014] In this manner, the light pipe 120 ensures that light is directed between the spectrometer 110 and the sample 130. The light pipe 120 surrounding the sample 130 provides a light source that is less sensitive to light than the exposed sample 130. The light pipe 120 is used to filter the amount of light lost from the spectrometer 110 and / or the light available from surrounding light sources. Improves the accuracy of spectroscopic measurements by reducing the amount of This reduces the amount of light that is incident on the sample 130, ensuring a relatively uniform illumination of the sample 130 and allowing spectroscopic measurements to be performed. This reduces the time required to
[0015] Additionally, the length 15 is selected based on the ideal spacing between the spectrometer 110 and the sample 130. 0 allows the light pipe 120 to provide a resolution for spectroscopic analysis compared to manually determining the spacing. This reduces the difficulty of aligning the spectrometer 110 with the sample 130. For example, provides a set of light pipes 120 associated with a set of different lengths 150 and a set of different samples 130, a particular light having an associated length 150 based on the sample 130 being measured. The pipe 120 may be selected.
[0016] FIG. 2 is an exemplary diagram of a system that may implement the systems and / or methods described herein. FIG. 2 illustrates an environment 200. As shown in FIG. 2, the environment 200 includes a spectrometer 212 and a light pipe. A spectroscopic assembly 210 having a 214, a server device 220, and a network 230. The devices in the environment 200 may be connected by wires, wirelessly, or a combination thereof. This can be done.
[0017] The spectroscopic assembly 210 includes one or more devices capable of performing spectroscopic measurements of a sample. For example, the spectroscopic assembly 210 may be used for spectroscopic analysis (e.g., a near-infrared (NIR) spectrometer, etc. Vibrational spectroscopy, mid-infrared spectroscopy (mid-IR), Raman spectroscopy, X-ray spectroscopy, ultraviolet A spectrometer 212 (e.g., a spectrometer for performing infrared (UV) spectroscopic analysis, deep ultraviolet spectroscopic analysis, visible light spectroscopic analysis, etc.) In some embodiments, the spectroscopic assembly 210 may include a spectroscopic device. In some embodiments, the spectrometer can be incorporated into a wearable device such as a wearable spectrometer. The optical assembly 210 includes an illumination source that generates light, a receiving light that is used for spectroscopy (e.g., a set of A spectroscopic module (e.g., In some embodiments, the spectroscopic assembly 210 may include a spectrometer 212. Disposable dip probes, disposable caps, etc., that must be replaced after each use In some embodiments, the spectroscopic assembly may include a set of disposable parts that can be used to The bridge 210 includes a set of reusable components, such as a reusable dip probe, a reusable cap, etc. It may have an available portion.
[0018] In some embodiments, the spectroscopic assembly 210 is provided by a spectrometer 212. In some embodiments, the processor may include a processor that performs RMID based on the spectroscopic measurements. The spectroscopic assembly 210 may include a calibration section for calibrating the spectrometer 212 and / or the RMID. In some embodiments, the spectroscopic assembly 210 includes a device (e.g., a light pipe 214 In some embodiments, the spectroscopic assembly 210 may include the assembly shown in FIG. In some embodiments, the spectrometer 212 corresponds to the spectrometer shown in FIG. 110. In some embodiments, light pipe 214 corresponds to the light pipe shown in FIG. In some embodiments, the spectroscopic assembly 210 corresponds to the environment 200. The server device 220 may receive information from, and send information to, another device within the network, such as the server device 220.
[0019] The server device 220 stores, processes, and / or routes information related to the spectroscopic measurements of the samples. For example, the server device 220 may include one or more devices capable of performing spectroscopic measurements of a sample. A system that receives a sample and performs RMID to identify the composition (e.g., a set of ingredients) of the sample. In some embodiments, the server device 220 may include a The server device 220 is provided with a communication interface that enables the server device 220 to transmit and receive data to and from other devices. It is possible.
[0020] Network 230 may comprise one or more wired and / or wireless networks. For example, the network 230 may include a cellular network (e.g., a Long Term Evolution LTE network, 3G network or Code Division Multiple Access (CDMA) network networks), Public Land Mobile Networks (PLMN), Local Area Networks (LONs), LAN, wide area network (WAN), metropolitan area network ( MAN), telephone networks (e.g., Public Switched Telephone Network (PSTN)), private networks, Hook networks, intranets, internet, optical fiber networks, cloud computing networks, and / or these or other types of networks There are combinations of networks.
[0021] The number and arrangement of devices and / or networks shown in FIG. 2 are provided as an example. In practice, more or fewer devices and / or networks may be used, or different devices and / or networks may be used. In addition, two or more of the devices shown in FIG. It may be implemented in a single device, or the single device shown in FIG. 2 may be implemented as multiple distributed devices. Additionally or alternatively, a set of devices in the environment 200 (e.g., , one or more devices) are described as being performed by another set of devices in the environment 200. It may perform one or more functions.
[0022] FIG. 3 illustrates exemplary components of the device 300. The device 300 includes a spectroscopic assembly. The spectrometer 212 may correspond to the server device 220. In an embodiment, the spectroscopic assembly 210 (e.g., the spectrometer 212) and / or the server device 220 includes one or more devices 300 and / or one or more components of the devices 300. As shown in FIG. 3, the device 300 may include a bus 310, a processor 320, a memory 330, and a 30, a storage unit 340, an input unit 350, an output unit 360 and a communication interface 370. It is possible.
[0023] Bus 310 includes components that enable communication between the components of device 300. The processor 320 may be implemented in hardware, firmware, or a combination thereof. can be.
[0024] The processor 320 includes a central processing unit (CPU), a graphics processing unit (GPU), and an acceleration Processing Unit (APU), Microprocessor, Microcontroller, Digital Signal Processor FPGAs, application specific integrated circuits (ASICs), In some embodiments, the processor may be a processor-based integrated circuit (SIC) or other type of processing component. The processor 320 may include one or more programmable logic units (PLCs) that may be programmed to perform functions. The memory 330 includes a random access memory (RAM), a read-only memory (WOM), and a ROM and / or information used by the processor 320 Other types of dynamic or static storage devices that store instructions (e.g., flash memory) , magnetic memory and / or optical memory).
[0025] Storage unit 340 stores information and / or software regarding the operation and use of device 300. For example, the storage unit 340 may include a hard disk (e.g., a magnetic disk, an optical disk, Magneto-optical disks and / or solid-state disks), compact disks (CDs) , digital versatile disk (DVD), floppy disk, cartridge, magnetic tape and / or any other type of non-transitory computer-readable medium that is compatible with the drive. .
[0026] Input section 350 accepts user input (e.g., a touch screen display, a keyboard, a keypad, The device 300 receives information by using a variety of methods, such as a mouse, a button, a switch, and / or a microphone. Additionally or alternatively, the device may include a component that allows the device to receive input The unit 350 includes a sensor for detecting information (e.g., a Global Positioning System (GPS) ), an accelerometer, a gyroscope, and / or an actuator. The device 300 (e.g., a display, a speaker, and / or one or more light emitting diodes ( It has a component that provides output information from a LED.
[0027] The communication interface 370 allows the device 300 to communicate with the A transceiver-like component that allows a device to communicate with other devices via a The communication interface 370 includes a The device 300 may be capable of sending and receiving information to and from another device. For example, The Interface 370 has an Ethernet interface, an optical interface, and a coaxial interface. Interface, infrared interface, radio frequency (RF) interface, universal USB interface, Wi-Fi interface, cellular -Network interfaces, etc.
[0028] The apparatus 300 may perform one or more of the processes described herein. The device 300 may include a non-transitory computer-readable medium, such as a memory 330 and / or a storage unit 340. These processes are responsive to the processor 320 executing stored software instructions. In this specification, a computer readable medium may be a non-transitory memory device. A memory device is defined as a memory area within one physical storage device or multiple physical storage devices. The memory area spans a variety of storage devices.
[0029] The software instructions may be transmitted via a communication interface from another computer readable medium or another device. The data can be read into the memory 330 and / or the storage unit 340 via the access 370. When executed, the software instructions stored in 330 and / or storage 340 cause the processor to The processor 320 may perform one or more of the processes described herein. Alternatively, hard-wired circuitry may be used in place of software instructions or in the form of software. may be used in conjunction with instructions to perform one or more of the processes described herein. Thus, the embodiments described herein may be implemented in any combination of hardware circuitry and software. The present invention is not limited to any particular combination.
[0030] The number and arrangement of components shown in FIG. 3 are provided as an example. 300 may include more or fewer components than those shown in FIG. 3, or may have different components than those shown in FIG. It may have different components or differently arranged components. Additionally or alternatively, a set of components of the device 300 (e.g., one or more The components are described as being performed by another set of components of the apparatus 300. The device may perform one or more of the functions described above.
[0031] FIG. 4 is a flow chart of an exemplary process 400 for performing ingredient identification using spectroscopy. In some embodiments, one or more of the process blocks of FIG. In some embodiments, the above may be performed on the optics 210 (e.g., the spectrometer 212). One or more of the process blocks of FIG. 4 may be implemented by a spectroscopic assembly 200, such as a server device 220. 10. An apparatus separate from the above, or a separate apparatus or group of apparatuses comprising a spectroscopic assembly. The process blocks of FIG. 4 may be performed on the Description will be given with reference to Figures 6C, 7A and 7B.
[0032] 5A and 5B are diagrams illustrating an example embodiment 50 of the example process 400 shown in FIG. 5A and 5B are examples of spectroscopic assembly 210 for ingredient identification.
[0033] 6A-6C are diagrams illustrating an example embodiment 400 of the example process 400 shown in FIG. 6A-6C are examples of another spectroscopic assembly 210 for ingredient identification.
[0034] 7A and 7B are diagrams illustrating an example embodiment 70 of the example process 400 shown in FIG. 7A and 7B are examples of yet another spectroscopic assembly 210 for performing ingredient identification. .
[0035] As shown in FIG. 4, process 400 includes the steps of aligning a sample with a spectrometer using a light pipe. For example, the spectrometer 212 may include a light pipe 214 for detecting the sample. In some embodiments, the light pipe 214 can be used to split the light. Separating the vessel 212 from the sample by a threshold distance (e.g., a distance that allows for spectroscopic measurements) For example, the light pipe 214 may surround a portion of the spectrometer 212 in a first portion of the cavity. Alternatively, the second portion of the cavity may surround the sample. In this case, the end of the spectrometer 212 is connected to the sample ( For example, from the edge of a pill in a blister pack, about 2 mm to about 10 mm, about 3 mm to about 5 mm In some embodiments, the distance may be a specific distance, such as mm. The cavity may be a hollow cavity, a solid cavity (e.g., a light-transmitting material), etc. In some embodiments, the light pipe 214 allows for adjustment of the distance between the spectrometer 212 and the sample. For example, as shown in FIG. 5A, the spacer structure 5 of the light pipe 214 may include a spacer. 05 (e.g., a ring spacer or a translucent disk spacer) is a spacer structure 505 The splitter 212 is attached to the light pipe 214 without the splitter 212. In another example, the light pipe 21 can be used to increase the distance between the light sources. 4 is a telescopic part, an extension tube part (for example, a main body part is attached to extend the light pipe 214). The device may have variable length sections, such as removable sections that shorten by removing the removable sections. In some embodiments, the light pipe 214 is a 20-mm square beam splitter 212 with respect to the light pipe 214. Use spacers to change the position or location of the sample 515 relative to the light pipe 214. It is possible.
[0036] In some embodiments, the light pipe 214 is inserted into the cavity of the light pipe 214. Based on the sample being measured, the sample can be aligned with the spectrometer 212. For example, When the surface of the plate 214 is placed adjacent to the base surface of a blister pack that contains the sample (e.g. For example, the blister pack may have a translucent plastic layer extending from the base surface to the light pipe 214. In the case where the sample is enclosed in a blister pack window, the sample enclosure of the blister pack (and the sample) is connected to the light pipe 214. In some embodiments, the light pipe 214 may extend to another type of sample. For example, the light pipe 214 may be enclosed in a blister pack. You can align items that are not aligned, such as pills, grains, seeds, etc. , the light pipe 214 can be positioned adjacent to the surface on which the item is placed.
[0037] Additionally or alternatively, light pipe 214 may be used to transmit another type of sample to spectrometer 212. For example, as shown in FIG. 5A and FIG. 5B, a sample (e.g., liquid A sample tube 515 (e.g., a vial, test tube, or cuvette) containing a sample or solvent sample 2. Place a cap (e.g., a cap that provides a substantial seal around the sample tube) over the opening of the light pipe 214. 520) to align the sample with the spectrometer 212. Light pipe 214 allows spectroscopic analysis of liquid or solvent samples to be performed in the sample tube. A substantial seal is one in which a threshold percentage of light passes through the opening. It is a seal to prevent
[0038] Similarly, as shown in FIGS. 6A and 6B, a sample pipe 605 (e.g., borosilicate glass Spectroscopic measurements are performed using a wide variety of tubes, including quartz silica glass tubes, plastic tubes, etc. A transparent glass or plastic tube in the region of the sample (e.g., a liquid sample or a solvent) is inserted into the sample. The sample is inserted into a light pipe 214 (e.g., a hollow cavity, a solid cavity (e.g., a sample pipe In this case, the optical pipe is guided through a cavity such as a 605 (including 606) as shown in FIG. 6B. The pipe 214 has openings 620-1 to 620-2 for introducing the sample pipe 605. 620-1 and 620-2 are provided with one or more seals and are substantially sealed around the sample pipe 605. This ensures a tight seal and ensures that the liquid or solvent sample is aligned with the spectrometer 212. Light pipe 214 allows spectroscopic analysis of a liquid or solvent sample introduced through the sample tube. In some embodiments, the light pipe 214 may be non-circular, such as elliptical or rectangular. A sample pipe 605 having a cross section of a light beam may be used. The type 214 is transparent (e.g., relatively close to the spectrometer 212) and 2) and a frosted top (relatively distant from the sample pipe 605). A sample pipe 605 having a substantially opaque portion may be used.
[0039] In another example, as shown in FIG. 6C, the sample pipe 605 is irradiated with light through an opening 630-1. The sample may be introduced into the cap 626 of the pipe 214. The cap 626 is a flow cell void. The sample may include a nozzle 635 through which the liquid or solvent sample is directed to the opening 630-2. Through this opening, the sample leaves the flow cell void 635 and enters the sample pipe 605. The flow cell 626 includes a window 640. The window provides a seal for the flow cell void 635 and allows light to pass through the spectrometer. 212 to the liquid or solvent sample (e.g., via light pipe 214). The cap 626 redirects light that is directed toward the liquid or solvent sample toward the spectrometer 212 (e.g., For example, the light splitting assembly may include a reflecting surface that reflects the light (through a light pipe 214). The tube 210 includes one or more caps 62 through which a liquid or solvent sample is introduced. 6, the testing of liquid or solvent samples can be expedited. Furthermore, the flow cell void 635 can be used as a cavity into which a liquid sample or a solvent sample is introduced. By using a circular cross section of the sample tube 605, a larger volume of the liquid or solvent sample can be obtained. This exposes a larger cross-sectional area to the light, resulting in more accurate spectroscopic measurements.
[0040] Additionally or alternatively, the light pipe 214 may be inserted into a sample container. Based on the portion of the pipe 214, the sample can be aligned with the spectrometer 212. For example, As shown in FIG. 7A and FIG. 7B, the light pipe 214 is connected to a dip probe 710 (e.g., a delta probe). The dip probe 710 may be attached to a sample container 711. 2, and a specific amount of the sample 712 (e.g., A liquid sample or a solvent sample can be placed in the sample space 713 aligned with the spectrometer 212. In this case, the light pipe 214 is arranged so that the spectrometer 212 does not contact the sample 712, and may include a window 714 to protect it from exposure to light.
[0041] In some embodiments, the light pipe 214 is configured to guide the sample through the spectrometer 21. 2, the sample can be surrounded. the surface to be irradiated (e.g., the base surface of a blister pack), the inner surface of the cavity of the light pipe 214 and may be surrounded by a window in the light pipe 214 located between the sample and the spectrometer 212 . In this case, the window ensures that the sensor of the spectrometer 212 is not exposed to particulate matter or the like. This can reduce the maintenance requirements associated with the spectrometer 212. In the present invention, a window may include a solid cavity portion (e.g., a solid cavity portion that transmits light). Additionally or alternatively, (e.g., if light pipe 214 does not include a window) ) The sample is attached to the surface on which it is placed, the inner surface of the cavity of the light pipe 214, and the spectrometer 21 It can be surrounded by 2.
[0042] In some embodiments, the light pipe 214 is a special light source that aligns the sample with the spectrometer 212. For example, the spectrometer 212 may be axially aligned. If there is a sample at the position, the corner of the cavity, the optical fiber part of the cavity (e.g. Optical fiber structures inside a fiber optic cable, optical fiber structures forming a solid cavity, etc. In this manner, the light pipe 214 connects the spectrometer 212 to the sample. In some embodiments, the light pipe 214 can be reflectively aligned. It may be specially shaped to accommodate a sample tube, such as a tube, and align the sample with the spectrometer. For example, as shown in FIG. 5A, light pipe 214 includes an opening 525 that accommodates sample tube 515. A cap 520 (e.g., optionally a reflective cap, a diffusive cap, or a light absorbing cap) In this case, the sample tube 515 is inserted into the cap 520 as shown in FIG. 5B. By inserting the sample into the cavity 530 of the light pipe 214, the sample is directed toward the spectrometer 212. The length of time can be extended.
[0043] In some embodiments, the light pipe 214 may be used to connect the spectrometer 212 to a light diffuser or It can be aligned with the surface of the reflector. For example, as shown in Figures 5A and 5B, Cap 535 (e.g., a Teflon core optical reflector such as a diffuse reflector, a specular reflector, etc.) A filter cap (such as a filter cap) may be inserted into the sample tube 515 to reflect the light toward the spectrometer 212. In this case, a cap of a specific size is selected to capture the ideal amount of sample, as shown in Figure 5B. may be included in the sample tube 515 to maintain a threshold thickness 540 of the sample. As shown in FIG. 6A and FIG. 6B, a cap 625 (e.g., a diffuse reflector, a specular reflector, A Teflon light diffusion cap or light reflection cap such as a Teflon light diffusion cap is inserted through the sample pipe 60. 5 may be arranged to surround the portion of the sample introduced into the light pipe 214. Alternatively, the light pipe 214 may be attached to a structure that supports a reflective or diffusive surface. For example, as shown in FIGS. 7A and 7B, a surface 720 (e.g., a Teflon sphere, A light diffusing or reflecting surface such as a fluororesin cylinder or a Teflon square pillar is measured by a dip probe 710. 212 and light pipe 214. The light may be diffused from or directed towards the spectrometer 212. The tip probe 710 may support the surface 720, such as by a pressure fit.
[0044] In some embodiments, the light pipe 214 may be positioned on a surface that acts as a light diffuser or reflector. For example, as shown in Figures 7A and 7B, a spacer may be provided to adjust the distance between the actuator and the spacer. A ring 725 may be included in or attached to the light pipe 214 and / or dip probe 710. The dip probe 710 is attached to the surface 720 of the light pipe 214 (and the spectrometer 2 12), the spacer ring 725 is attached to the light pipe 214 and / or the dip probe 710. may extend further than if it were not included in or attached to Similarly, a cap (e.g., a light reflector or light diffuser) may be associated with the spacer. , the distance between the cap and the sample or the spectrometer 212 can be changed.
[0045] As further shown in FIG. 4, the process 400 is based on aligning the sample with the spectrometer using a light pipe. The method may include performing a set of spectroscopic measurements of the sample based on the results (block 420). For example, The spectrometer 212 detects a portion of the sample based on the alignment of the sample with the spectrometer 212 using a light pipe 214. In some embodiments, the spectrometer 212 can perform a set of spectroscopic measurements. The light can be directed to the sample via a spectrometer 214. For example, the spectrometer 212 can be a set of spectroscopic measurements. 212. The spectrometer 212 generates light for performing the measurement and directs the light to the sample based on the alignment of the sample with the spectrometer 212. It is possible.
[0046] Additionally or alternatively, the splitter 212 may be based on the reflective surface of the light pipe 214: For example, the cavity of the light pipe 214 may have a reflective surface (e.g. It contains a 3-layer anodized aluminum surface that allows the light to be directed towards the sample. Alternatively, the light pipe 214 may include a light pipe that can reflect light toward the sample. It may comprise a Mylar foil-faced cylinder inserted into the cavity of the pipe 214. Additionally or alternatively, a light pipe 214 may direct light between the spectrometer 212 and the sample. In this manner, the light pipe 214 may include a corner portion, a fiber optic portion, and / or a light emitting diode portion. This increases the amount of light directed to the sample compared to the light divergence without the use of the probe 214. This can improve the accuracy of the spectroscopic measurements. Compared to conventional methods, it reduces the amount of ambient light illuminating the sample, thereby improving the accuracy of spectroscopic measurements. Additionally, the light pipe 214 can be used to diffuse light and / or ambient light without the use of the light pipe 214. Compared to light, it ensures relatively uniform illumination of the sample.
[0047] In some embodiments, the spectrometer 212 may receive light reflected from the sample. For example, in a spectrometer 212 that directs light to a sample through a light pipe 214, the reflected light is The light can be directed through a light pipe 214 to a spectrometer 212. Based on the surface of the star pack, the light pipe 214 is exposed without the use of the light pipe 214. Similarly, the light pipe 214 reduces the scattering of the reflected light compared to a sample that is not covered by the light pipe 214. Reduces the amount of ambient light directed to the spectrometer 212 compared to a sample exposed without .
[0048] In some embodiments, the spectrometer 212 may be configured to receive a signal from the spectrometer 212 in response to the light received by the spectrometer 212. For example, the spectrometer 212 may receive a sample and perform one or more spectroscopic measurements. 2. Generate light that is directed by light pipe 214 between chambers 212, one or more of the light In this way, the spectrometer 212 uses the light pipe 214 to analyze the sample. Take a light measurement.
[0049] As further shown in FIG. 4, the process 400 identifies a set of components of a sample based on a set of spectroscopic measurements. For example, the spectrometer 212 may determine a set of spectroscopic measurements (block 430). In some embodiments, a set of components of a sample can be determined based on the determination. The spectrometer 212 provides information identifying the set of spectroscopic measurements to the server device 220. In some embodiments, the device 220 may determine the set of components. The spectrometer 212 can determine the set of components using a particular classification technique. For example, The spectrometer 212 uses a support vector machine (SVM) classifier to classify one or more The components can be identified.
[0050] In some embodiments, the spectrometer 212 performs a spectroscopic analysis based on a set of spectroscopic measurements and a set of calibration measurements. For example, the spectrometer 212 may, for example, The light pipe 214 is not enclosed in a light diffusion cap or a light reflection cap. align the cap with the light pipe 214, misalign the cap with the light pipe 214, etc., and perform calibration measurements. The spectrometer 212 can be calibrated by obtaining a calibration measurement of The spectrometer 212 uses a comparison technique to compare the set of spectroscopic measurements to a set of calibration measurements to determine the One or more components of the above can be determined.
[0051] In some embodiments, the spectrometer 212 provides information that identifies a set of components of a sample. For example, the spectrometer 212 may be configured to In addition, or in addition, the method may provide information that identifies a set of components of a sample. Alternatively, the spectrometer 212 may generate information identifying a set of components for display, for storage, etc. may be provided via a separate device. The system may provide an alert or notification based on a set of components. For example, If there is a mismatch with the expected set of components, the spectrometer 212 can provide a warning (e.g. (e.g., displaying to inspectors or disabling pipes carrying samples).
[0052] FIG. 4 illustrates example blocks of a process 400, in some embodiments. However, the process 400 may have more or less blocks, and may have different blocks. 4. In addition, the Alternatively, two or more blocks of process 400 may be performed in parallel.
[0053] As noted above, Figures 5A and 5B are provided as examples only. Other examples are possible. 5A and 5B.
[0054] As noted above, FIGS. 6A-6C are provided as examples only. Other examples are possible. and may be different from that described with respect to Figures 6A-6C.
[0055] As noted above, Figures 7A and 7B are provided as examples only. Other examples are possible. 7A and 7B.
[0056] 8A-8C illustrate an example embodiment 800 of the example process 400 shown in FIG. 8A-8C show another example of a spectroscopic assembly for performing raw material identification. There are.
[0057] As shown in FIG. 8A, a light pipe 814 is attached to the splitter 212. In an embodiment, light pipe 814 corresponds to light pipe 214. Light pipe 814 is A cap 816, a rotor assembly 818, a switch 820, a window 822, a mirror 824, and a cap In some embodiments, the cap 816 is pointed. This allows the light pipe 814 to be inserted into a sample, such as a soil sample in the ground. Additionally or alternatively, the cap 816 may have a threaded or other feature that allows for insertion into the sample. In some embodiments, the rotor assembly may have a cap in the shape of 818 may include a motor, a battery, etc. In some embodiments, switch 820 A switch for operating the motor of the rotor assembly 818 may be included. For example, The rotation speed can be varied based on the switch 820. Based on the operation switch 820, the reflective angle associated with the mirror 824 can be changed. In some embodiments, a controller (e.g., of the spectrometer 212) may control the switch 8 20 can be automatically operated to control the motor of the rotor assembly 818. As shown in FIG. 1, the mirror 824 is rotated to obtain a 360-degree spectroscopic sample by the spectrometer 212. It is possible.
[0058] In some embodiments, the window 822 surrounds the mirror 824 and is axially spaced from the cavity 826 . In some embodiments, the mirror 824 may include a transparent window aligned in the gold direction. The mirror surface may be a metal-based mirror surface, a glass-based mirror surface, or the like. In some embodiments, the window 822 may be a glass window, a plastic window, or the like, and may be used to mirror the sample. It can be directed at a sample outside of the light pipe 814 without touching 824. In some embodiments, the cavity 826 is configured to allow the light pipe 814 to penetrate the sample to a selected depth. As shown by reference numeral 828, the light can be inserted into the optical fiber 810. A pipe 814 passes light from the spectrometer 212 into a cavity 826 (e.g., a cavity with reflective walls). The light is reflected by mirror 824 and directed through window 822 to sample 830. In this case, the light is reflected by the sample 830, through the window 822, and onto the mirror 824, The light is guided into the cavity 826 and into the spectrometer 212, which can perform spectroscopic measurements. In operation, the rotator assembly 818 rotates the mirror 824 to adjust the insertion of the light pipe 814. The light is directed towards and reflected from different parts of the sample.
[0059] In this manner, the light pipe 814 is tested using the mirror 824 and the rotator assembly 818. This allows for rotational scanning of the sample, which allows multiple parts of the sample to be measured. For example, spectrometer 212 may use light pipe 814 to obtain data regarding the spectral variations of the sample. and determine the average spectrum of the sample to perform RMID of this sample. .
[0060] As shown in FIG. 8B, a similar light pipe 814' is used to rotate the light using a rotor assembly 818. The light pipe 814' is fitted with a cap 816', a window 822', cavity 826'-1, cavity 826'-2 and cavity bend 83 In some embodiments, the cavity 826′-1 may include a spectrometer 212. In some embodiments, the cavity may include a cylindrical cavity for receiving the The spectrometer 826'-1 has various cross-sectional shapes corresponding to the cross-sectional shapes of the output of the spectrometer 212. In some embodiments, the cavity 826'-2 can be configured to fold the light into the cavity. 832. In some embodiments, the cross-section of the casing 832 may be rectangular. The cavity bend 832 can redirect light from the spectrometer 212 to the window 822'. For example, the cavity bend 832 directs light perpendicular to the cavity 826'-2 and toward the window 826'-3. 822′. In this case, the light pipe 814′ may be manually rotated to By rotating the window 822', rotational scanning can be performed without the rotor assembly 818. Additionally or alternatively, an external component such as a rotor assembly of the spectrometer 212 may be An external device can be used to rotate the light pipe 814'.
[0061] As shown in FIG. 8C, a similar light pipe 814″ can be used to illuminate the light pipe 814″ or one of its The light pipe 814" can be rotated and scanned without rotating the cap 81. 6”, window 822”, mirror 824”, cavity 826”, and cavity housing 834. The cavity 826" can be placed within a cavity housing 834. In this case, The light is directed from the beam splitter 212 to a mirror 824″ through a cavity 826″. In some embodiments, the mirror 824" can be oriented 360 degrees, for example, through a window 822". In other words, the light can be diverged into a light pipe. The light is directed toward a sample surrounded by a filter 814" and can be scanned in each direction simultaneously. , which is reflected by the sample aligned with window 822″ toward mirror 824″, The light can be directed through cavity 826″ to spectrometer 212. In this manner, The splitter 212 may be configured to rotate the light pipe 814″ or any portion of the light pipe 814″ without rotating the light pipe 814″ (e.g., Average spectrum of a sample surrounded by light pipe 814″ (e.g., aligned with window 822″) can be obtained.
[0062] In this manner, spectroscopic samples of dissimilar materials can be taken using light pipes 814, 814' or 814''. This allows for a much faster and more accurate measurement than moving the spectrometer to different locations in the sample area. Therefore, the time required to obtain a spectroscopic sample can be reduced. This reduces power consumption and eliminates the need to move the spectroscopy sample. Based on this avoidance, the spectrometer can be moved to a different location within the sample, resulting in a faster analysis time. The accuracy and reproducibility of the light measurements can be improved.
[0063] As noted above, FIGS. 8A-8C are provided as examples only. Other examples are possible. , which may be different from that described with respect to FIGS. 8A-8C.
[0064] 9A and 9B are diagrams illustrating an example embodiment 90 of the example process 400 shown in FIG. 9A and 9B show another example of a spectroscopic assembly 210 for ingredient identification. is doing.
[0065] As shown in FIG. 9A, a light pipe 914 is connected to the spectrometer 212 to measure the intensity of a sample (e.g., a gas sample). The light pipe 914 may be arranged to provide a cavity 916, a The cap 918 may include an input 920 and an output 922. For example, a liquid or gas may be input 920 (e.g., a first opening in cavity 916 that contains a liquid or gas). or through a cavity 916 (e.g., a hollow optical cavity with reflective surfaces). An output 922 (e.g., a second opening in the cavity 916 that emits liquid or gas) In this case, the spectrometer 212 may irradiate light into the cavity 916 to measure the liquid. For example, the light pipe 914 can be used to measure the wavelength of light from the spectrometer 212 to the The light is received and directed to the cap 918. In this case, the light is directed to the cap 918 (e.g. 212 (e.g., via cavity 916 ). In some embodiments, the cavity 916 is configured to include a sample in the cavity 916. A threshold axis that allows for a threshold absorption of the light emitted by the spectrometer 212. This can be the threshold axial length, allowing for spectroscopic analysis of the sample.
[0066] A similar light pipe 914' is shown in FIG. 9B, which includes a cavity 916', a cap 918', and an inlet In this case, the cavity 916' may include a force portion 920' and an output portion 922'. 24, which allows the light emitted from the spectrometer 212 to travel through the cap 918′. without increasing the threshold lateral distance of the cavity 916′ from the spectrometer 212. The absorption of light by the sample in the cavity 916' can be increased. The pipe 914' can be constructed in a compact package to allow for spectroscopic analysis of samples. This can be done.
[0067] In this manner, the light pipe 914 allows the spectrometer 212 to be, for example, It becomes possible to perform spectroscopic analysis of gases.
[0068] As noted above, Figures 9A and 9B are provided as examples only. Other examples are possible. 9A and 9B.
[0069] FIG. 10 illustrates an example implementation 1000 of the example process 400 shown in FIG. FIG. 10 illustrates another example of a spectroscopic assembly 210 for ingredient identification.
[0070] As shown in FIG. 10, a light pipe 1014 is connected to a spectrometer 212 to perform spectroscopic measurements of the sample. The light pipe 1014 includes a cavity housing 1020, a cavity 1022, A spacer 1024, a window 1026, and a mirror 1028 may be included. 2 to form a cavity 1022 (e.g., a hollow cavity, a light-transmitting solid cavity, etc.) A window 1026 (e.g., a sapphire window, a glass window, a plastic window, or other window) is inserted through the The mirror 10 can be directed toward a sample (e.g., a liquid sample) placed on the optically transparent window of the mirror 10. 28 is another window (e.g., another sapphire window, a glass window, a plastic window, or other light-transmitting window). Transmissive window) and reflector (e.g., diffuse reflector associated with threshold reflectance of 95%, 99%, etc. 1028 has a hinged reflector 1030 that allows the mirror 1028 to be repositioned between an open and a closed position. In the open position, the sample is exposed to the window 1026 and mirror 1028 as shown. In the closed position, the The sample is surrounded by a spacer 1024, a window 1026, and a mirror 1028. Thus, the mirror 102 is spaced a threshold distance from the window 1026 to obtain a threshold thickness of the sample for measurement. After passing through the sample, the light is reflected by a mirror 1028 and directed to a spectrometer 212 (e.g., For example, the measurement may be performed by reflection through a window 1026 and a cavity 1022.
[0071] In some embodiments, the sample is not placed between the window 1026 and the mirror 1028, and the light is Alternatively, the light may be returned to the spectrometer 212 by a mirror 1028. may take a baseline measurement associated with mirror 1028. In the present invention, a spectroscopic assembly 210 including a spectrometer 212 and a light pipe 1014 is provided with a sensor system. For example, a temperature sensor and / or a thermoelectric cooler / heater may be provided adjacent to the window 1026. In this way, the temperature of the sample can be measured and controlled. In some embodiments, the spacer 1024 may be a repositionable spacer (e.g., For example, a phosphorescent light source 1026 extends along the optical axis of the light pipe 1024 from the window 1026 to the mirror 1028. A spacer (such as a spacer having a shape of a bracket or other shape) is provided to adjust the distance between the window 1026 and the mirror 1028. , thereby controlling the thickness of a sample placed between the window 1026 and the mirror 1028. In some embodiments, the window 1026 and the mirror 102 8 is installed at an angle to the optical axis of the light pipe 1014 as shown in the figure, and aligned with the optical axis. Mirror 1028 is a mirror for reflecting light from mirror 1028. Reduce surface area and provide users with an ergonomic grip design. can.
[0072] In this way, the light pipe 1014 is used to perform spectroscopic measurements of a sample (e.g., a liquid sample). This eliminates the need for vials, cuvettes, etc., reducing the cost of spectroscopy analysis. Additionally, the light pipe 1014 improves spectroscopic accuracy by ensuring uniform thickness and placement of the sample. Increases the accuracy of the analysis. Furthermore, by eliminating the need for vials or cuvettes, For example, rather than placing a vial or vials of sample, the sample can be placed directly into the light pipe 1014. The accuracy of the spectroscopic measurements can be improved based on the improved homogeneity of the sample. For example, a pair of flat windows (e.g., window 1026 and the window of mirror 1028) may be used. By enclosing the sample, cleaning is much easier than cleaning a vial or cuvette. The difficulty can be reduced.
[0073] As noted above, FIG. 10 is provided as an example only. Other examples are possible. It may be different from that described with respect to FIG.
[0074] In this manner, the spectroscopic assembly 210 allows the use of a spectrometer 212 without a light pipe 214. 2, a light pipe 214 is used between the spectrometer 212 and the sample (e.g., a transmission 212 and 213. By reducing the amount of ambient light to which the sample is exposed, the accuracy of spectroscopic measurements can be improved. Furthermore, by providing an opening in the light pipe 214 where a sample can be placed, The sample 214 is placed at a particular distance selected to enhance the accuracy of one or more spectroscopic measurements. This allows the material and the spectrometer 212 to be quickly aligned.
[0075] While the above disclosure provides illustrations and descriptions, it is not intended to be exhaustive or to limit the scope of the present invention. It is not intended to be exhaustive or to be limited to the precise form disclosed. Modifications and variations may be made as described above. This may be implemented in light of the disclosure or by practice of the embodiments.
[0076] Some embodiments have been described herein in connection with a threshold value. "Meeting the threshold value" means a value that is greater than the threshold value, a value that exceeds the threshold value, a value that is higher than the threshold value, a value that is less than the threshold value, Above, below, less than, less than, below, equal to, For example,
[0077] Particular user interfaces are described herein and / or illustrated in the figures. The interface can be a graphical user interface or a non-graphical user interface. User interfaces include text-based user interfaces, and The interface provides information for display. In some embodiments, the user The information is inputted through an input unit of a device that provides a user interface for the In some embodiments, the user interface The system may be configurable by the device and / or the user (e.g., the user may configure the user interface). the size of the user interface, the information provided through the user interface, (e.g. change the location of information provided via the service). Instead, the user interface is configured as a standard configuration, A specific configuration based on the type of device on which the user interface is displayed and / or the device on which the user interface is displayed. The device may be pre-configured into a set of configurations based on the capabilities and / or specifications associated with the device.
[0078] The systems and / or methods described herein may be implemented in hardware, firmware, or Obviously, this can be implemented in various forms using a combination of hardware and software. The actual dedicated control hardware used to implement these systems and / or methods may be The hardware or software code does not limit the embodiment. The operations and behavior of the systems and / or methods herein are referred to as specific software code. The software and hardware described herein are not intended to be limiting. It will be understood that the present invention may be designed to perform the steps of the method and / or the method.
[0079] Although particular combinations of features are set out in the claims and / or specification, these combinations The above description is not intended to limit the disclosure of possible embodiments. Many of the features of the present invention may be combined in ways not explicitly set forth in the claims and / or specification. Each dependent claim below depends directly on only one claim, but may be implemented in any manner. The disclosure of possible embodiments is based on each dependent claim in combination with all other claims falling within its scope. This includes.
[0080] Any element, operation or instruction used herein is intended to be illustrative unless expressly described as such. In addition, as used herein, "a" or "b" means "an element or element that is essential to the intended purpose of the present invention. The articles " and "an" are intended to include one or more items, and "one or more" is used interchangeably. " may be used interchangeably with ". Additionally, as used herein, "set" refers to one or Multiple items (e.g., related items, unrelated items, or a combination of related and unrelated items) "one or more" is intended to include all elements of the term "one or more" and may be used interchangeably with "one or more." When only one is intended, the term "1" or similar terminology is used. The terms "has," "have," "having," etc., which are used in Moreover, the phrase "based on" is intended to be used interchangeably with "based on" unless otherwise specified. Unless otherwise stated, "based at least in part on" shall mean "based at least in part on."
Claims
1. a light pipe having a dip probe and a body having a cavity therein through which light passes; a sample container configured to contain the sample; A spectrometer; The dip probe is configured to support a surface of an optical diffuser or optical reflector to place a specific amount of the sample in a sample space aligned with the spectrometer, whereby the light is directed toward the sample and subsequently diffused or directed toward the spectrometer.
2. The system of claim 1 , wherein the specific amount of sample is placed in the sample space without exposing the spectrometer to the sample.
3. The system of claim 1 , wherein the light pipe comprises a window to protect the spectrometer from contacting the sample.
4. 2. The system of claim 1, wherein when the light pipe aligns the sample with the spectrometer, the sample is surrounded by a surface of the light diffuser or light reflector on which the sample is placed and an inner surface of the light pipe cavity or a window of the light pipe.
5. 10. The system of claim 1, wherein the light pipe further comprises a window configured to be positioned between the sample and the spectrometer.
6. The system of claim 1 , wherein the surface is supported by the dip probe by a pressure fit.
7. 10. The system of claim 1, further comprising a spacer ring included in or attached to one or both of the light pipe or the dip probe such that the dip probe extends a surface of the light diffuser or light reflector from the light pipe.
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