Automatic analysis device

Abstract

To provide an autoanalyzer designed to detect the abnormality of two or more trains of piping while avoiding a decrease in the accuracy of detecting abnormality, an increase in data amount and device size and an increase in cost.SOLUTION: The autoanalyzer includes an A train 35 and a B train 36 which are independent of each other. The suction states of the A train 35 and B train 36 are individually controlled by having an A-side two-way solenoid valve 101 and a B-side two-way solenoid valve 102 individually. A determination unit 103 compares the measured pressure values by suction pertaining to the A train 35 and B train 36 on the basis of the measured pressure value of a reagent probe cleaning tank-side vacuum pump 87 that is measured by a reagent probe cleaning tank-side pressure sensor 71 and thereby detects the abnormality of the autoanalyzer.SELECTED DRAWING: Figure 7

Description

[Technical field]

[0001] The present invention relates to an automatic analyzer. [Background technology]

[0002] Patent Document 1 describes an automatic analyzer equipped with a vacuum suction device for vacuum-suctioning a post-analysis reaction liquid from a reaction vessel. This patent document describes "an automatic analyzer characterized by comprising a vacuum pump, a vacuum tank connected to the vacuum pump, a vacuum bottle connected to the vacuum tank, a unit having a plurality of suction nozzles for respectively sucking liquid from a plurality of reaction vessels and connected to the vacuum bottle, and a pressure adjustment mechanism for adjusting the suction pressure of the suction nozzle between the vacuum pump and the vacuum tank." It also describes that "if the automatic analyzer is installed in an environment with a different external air pressure, the performance of the vacuum pump decreases."

[0003] A pressure control system in a flow system for an automatic biochemical analyzer that can measure the pressure in the flow system for an automatic biochemical analyzer and output an alarm signal and the type of alarm according to the pressure value is described in Patent Document 2. Patent Document 2 describes that "if the check valve remains closed, the pressure is determined to be much lower than the lower threshold at the time of pressure measurement, and therefore an abnormality is detected," "if the check valve does not close, the pressure is determined to be lower than the lower threshold at the time of pressure measurement, and therefore an abnormality is detected in the check valve," and "if the solenoid valve remains closed, the pressure in the flow path exceeds the upper threshold in the cleaning water discharge mode, and therefore an abnormality is detected in the solenoid valve." [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Patent Publication No. 2018-159682 [Patent Document 2] Patent Publication No. 2010-217147 Summary of the Invention [Problem to be solved by the invention]

[0005] The vacuum pump mounted on the vacuum suction device described in Patent Document 1 varies in performance when the air pressure changes, resulting in daily performance differences. Therefore, when attempting to detect abnormalities in the vacuum suction device, such as malfunction of the solenoid valve, blockage of piping, or breakage of piping, from the pressure of the vacuum tank, it is difficult to distinguish whether the abnormality is due to daily differences in the vacuum pump or an abnormality, resulting in a problem of reduced accuracy in detecting the abnormality.

[0006] The above-mentioned Patent Document 2 describes a pressure control system for a flow system of an automatic biochemical analyzer that can measure pressure and output an alarm signal and the type of alarm according to the pressure value. The pressure control system described in Patent Document 2 sets upper and lower thresholds for pressure, and determines that there is an abnormality in a check valve or a solenoid valve when the pressure is higher than the upper threshold or lower than the lower threshold.

[0007] When setting the threshold value in this way to detect an abnormality in the vacuum suction flow path, the threshold value must be set broadly to take into account pressure fluctuations due to daily and individual differences in the vacuum pump. For example, if the average pressure of a vacuum pump during normal operation is -50 kPa and the daily difference is ±3 kPa, the pressure during normal operation will be between -53 kPa (=-50 kPa-3 kPa) and -47 kPa (=-50 kPa+3 kPa).

[0008] Assuming that there is a pressure fluctuation of ±2 kPa or more during an abnormality, the lower threshold is the minimum pressure during normal operation, i.e., -55 kPa (=-53 kPa-2 kPa), and the upper threshold is -45 kPa (=-47 kPa+2 kPa). Here, if the pressure during normal operation is -53 kPa and there is a pressure fluctuation of +2 kPa due to an abnormality, the actual pressure will be -51 kPa (=-53 kPa+2 kPa), but this is within the threshold (-55 kPa to -45 kPa) and is not determined to be an abnormality.

[0009] Thus, there has been a problem in that setting a threshold value taking into account daily differences in the pump reduces the accuracy of anomaly detection.

[0010] In addition, the pressure control system described in Patent Document 2 acquires pressure over all time periods. Therefore, in the case of a large device that has multiple other mechanisms and sensors and needs to acquire multiple measured values, acquiring pressure over all time periods results in a large amount of data, which is a problem.

[0011] Furthermore, the pressure control system described in Patent Document 2 detects abnormalities in only one system, i.e., the cleaning water supply pipe of the sample dispensing device. Therefore, when detecting abnormalities in a second and third system in addition to the cleaning water supply pipe, i.e., abnormalities in pipes of multiple systems, a pressure sensor must be installed for each system, which causes problems such as the device becoming larger and the cost becoming higher. Furthermore, there is also a problem in that the amount of data becomes large because data is also acquired from the second pressure sensor.

[0012] An object of the present invention is to provide an automatic analyzer capable of detecting abnormalities in piping of two or more systems while avoiding a decrease in accuracy of abnormality detection, an increase in the amount of data, an increase in the size of the device, and an increase in cost. [Means for solving the problem]

[0013] An example of an automatic analyzer according to the present invention is A first vacuum pump; a first vacuum tank connected to the first vacuum pump; A first pressure sensor installed in the first vacuum tank; a first vacuum bottle connected to the first vacuum tank; A plurality of first suction solenoid valves; A control unit; A determination unit; An automatic analyzer comprising: The first vacuum tank sucks liquid from a plurality of reaction vessels or cleaning tanks each containing a liquid, each of the first suction solenoid valves is disposed between the first vacuum tank and the first vacuum bottle, and opens and closes when the first vacuum tank sucks liquid to adjust a suction pressure; The control unit controls opening and closing of each of the first suction solenoid valves, The automated analyzer has a plurality of independent aspiration systems, Each of the suction systems has the first suction solenoid valve, and the suction state is controlled individually. The determination unit detects an abnormality in the automated analyzer by comparing the pressure measurement values ​​during suction related to each of the suction systems based on the pressure measurement value of the first vacuum tank measured by the first pressure sensor. Effect of the Invention

[0014] According to the present invention, it is possible to provide an automatic analyzer that is capable of detecting abnormalities without reducing accuracy even when there are day-to-day or individual differences in pump performance.

[0015] Furthermore, it is possible to provide an automatic analyzer that can suppress an increase in data volume and detect abnormalities, even in large equipment that has multiple other mechanisms and sensors and must obtain multiple measurement values.

[0016] Furthermore, it is possible to provide an automatic analyzer that is capable of detecting abnormalities while suppressing increases in size, cost, and data volume, even when detecting abnormalities in piping for multiple systems.

[0017] Other objects, configurations and advantages than those described above will become apparent from the following description of the embodiments. [Brief description of the drawings]

[0018] [Figure 1] FIG. 1 is a schematic diagram of an automatic analyzer according to a first embodiment of the present invention. [Diagram 2] FIG. 2 is a schematic configuration diagram of a reagent probe washing tank side suction unit according to the first embodiment of the present invention. [Diagram 3] FIG. 2 is a schematic configuration diagram of a reagent probe washing tank side suction unit and a reaction container side suction unit according to the first embodiment of the present invention. [Figure 4] FIG. 4 is a diagram showing the operation of each solenoid valve according to the first embodiment of the present invention. [Figure 5A] 5 is a diagram showing pressure fluctuations in a vacuum tank when the solenoid valve operation shown in FIG. 4 is performed (under normal conditions). [Figure 5B] A graph showing the maximum values ​​for each cycle extracted from the pressure fluctuations in the vacuum tank shown in Figure 4 (under normal conditions). [Figure 6A] 5 is a diagram showing pressure fluctuations in a vacuum tank on the reagent probe washing tank side when the solenoid valve operation shown in FIG. 4 is performed (when the solenoid valve is abnormally closed). [Figure 6B] FIG. 6B is a diagram showing the maximum values ​​for each cycle extracted from the pressure fluctuations in the vacuum tank on the reagent probe washing tank side shown in FIG. 6A (when the solenoid valve is abnormally closed). [Figure 7] 4 is a flowchart of an anomaly detection process according to the first embodiment of the present invention. [Figure 8A] 5 is a diagram showing pressure fluctuations in a vacuum tank on the reagent probe washing tank side when the solenoid valve operation shown in FIG. 4 is performed (when the solenoid valve is abnormally open). [Figure 8B] FIG. 8B is a diagram showing the maximum values ​​for each cycle extracted from the pressure fluctuations in the vacuum tank on the reagent probe washing tank side shown in FIG. 8A (when the solenoid valve is abnormally open). [Figure 9A] 5 is a diagram showing pressure fluctuations in a vacuum tank on the reagent probe washing tank side when the solenoid valve operation shown in FIG. 4 is performed (when the flow path is blocked). [Figure 9B] FIG. 9B is a diagram showing the maximum values ​​for each cycle extracted from the pressure fluctuations in the vacuum tank on the reagent probe washing tank side shown in FIG. 9A (when the flow path is blocked). [Figure 10A] 5 is a diagram showing pressure fluctuations in a vacuum tank on the reagent probe washing tank side when the solenoid valve operation shown in FIG. 4 is performed (when there is a flow path leak). [Figure 10B] FIG. 10B is a diagram showing the maximum values ​​for each cycle extracted from the pressure fluctuations in the vacuum tank on the reagent probe washing tank side shown in FIG. 10A (when there is a leak in the flow path). [Figure 11] FIG. 11 is a schematic configuration diagram of a reagent probe washing tank side suction unit, a reaction container side suction unit, and a liquid supply unit according to a second embodiment of the present invention. [Figure 12A] 5 is a diagram showing pressure fluctuations in a vacuum tank on the reagent probe washing tank side when the solenoid valve operation shown in FIG. 4 is performed (when a liquid supply abnormality occurs). [Figure 12B]FIG. 12B is a diagram showing the maximum values ​​for each cycle extracted from the pressure fluctuations in the vacuum tank on the reagent probe washing tank side shown in FIG. 12A (when an abnormality occurs in the liquid supply). [Figure 13] 10 is a flowchart of anomaly detection according to a second embodiment of the present invention. [Figure 14] FIG. 11 is a diagram showing the operation of a water supply two-way solenoid valve and a reaction vessel side three-way solenoid valve according to the third embodiment of the present invention. [Figure 15A] 15 is a diagram showing pressure fluctuations in a vacuum tank on the reaction vessel side when the solenoid valve operation shown in FIG. 14 is performed (normal state). [Figure 15B] A diagram showing the maximum values ​​for each cycle extracted from the pressure fluctuations in the vacuum tank on the reaction vessel side shown in Figure 14 (under normal conditions). [Figure 16A] FIG. 15 is a diagram showing pressure fluctuations in a vacuum tank on the reaction vessel side when the solenoid valve operation shown in FIG. 14 is performed (when water supply abnormality occurs). [Figure 16B] FIG. 16B is a graph showing the maximum values ​​for each cycle extracted from the pressure fluctuations in the vacuum tank on the reaction vessel side shown in FIG. 16A (when there is an abnormality in the water supply). [Figure 17] 11 is a flowchart of an anomaly detection process according to the third embodiment of the present invention. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0019] Hereinafter, the embodiments will be described with reference to the drawings. EXAMPLES

[0020] An embodiment of the present invention will now be described with reference to Figs. 1 to 10B. Fig. 1 is a schematic diagram of an automatic analyzer according to Example 1. The configuration of the automatic analyzer is not limited to that shown in Fig. 1, and the present invention can be applied to, for example, a general automatic analyzer.

[0021] In Fig. 1, reaction containers 2 are arranged circumferentially on a reaction disk 1. A plurality of reagent bottles 10 are arranged circumferentially on a reagent disk 9. A detergent bottle 6 can also be arranged on the reagent disk 9. A sample transport mechanism 17 that moves a rack 16 carrying sample containers 15 is also installed near the reaction disk 1.

[0022] Between the reaction disk 1 and the reagent disk 9, an A-side reagent dispensing mechanism 7 and a B-side reagent dispensing mechanism 8 that can rotate and move up and down are installed, and each is equipped with an A-side reagent probe 22 and a B-side reagent probe 23. The A-side reagent probe 22 and the B-side reagent probe 23 are moved up and down and horizontally by the A-side reagent dispensing mechanism 7 and the B-side reagent dispensing mechanism 8, respectively.

[0023] A reagent syringe 18 is connected to each of the A-side reagent probe 22 and the B-side reagent probe 23. In response to the operation of the reagent syringe 18, the A-side reagent probe 22 and the B-side reagent probe 23 aspirate and discharge reagent. The reagent syringe 18 also aspirates and discharges detergent from the detergent bottle 6, thereby cleaning the insides of the A-side reagent probe 22 and the B-side reagent probe 23.

[0024] A rotatable and vertically movable sample dispensing mechanism 11 is installed between the reaction disk 1 and the sample transport mechanism 17, and is equipped with a sample probe 12. A sample syringe 19 is connected to the sample probe 12. The sample probe 12 moves horizontally while drawing an arc around the rotation axis, and also moves vertically to dispense a sample from a sample container 15 to a reaction container 2.

[0025] Arranged around the reaction disk 1 are a cleaning mechanism 3, a spectrophotometer 4, stirring mechanisms 5a and 5b, a reagent disk 9, and a sample transport mechanism 17. The spectrophotometer 4 receives light emitted from a light source (not shown).

[0026] The cleaning mechanism 3 cleans the reaction vessel 2 by sucking and discharging a cleaning liquid into the reaction vessel 2 .

[0027] Washing tanks 30a and 30b for the stirring mechanisms are disposed above the movement ranges of the stirring mechanisms 5a and 5b. Furthermore, washing tanks 31 and 32 for the A-side reagent probe are disposed above the movement ranges of the A-side reagent probe 22 and the B-side reagent probe 23. Furthermore, washing tanks 34 for the sample probe are disposed above the movement range of the sample probe 12.

[0028] Here, a method of analyzing a sample will be described. A sample container 15 containing a test sample such as blood is placed on a rack 16 and transported by a sample transport mechanism 17. The sample to be tested is dispensed from the sample container 15 into a reaction container 2 by a sample probe 12. A reagent is dispensed from a reagent bottle 10 into the reaction container 2 by an A-side reagent probe 22 and a B-side reagent probe 23. The sample and reagent are stirred in the reaction container 2 by stirring mechanisms 5a and 5b, and the mixture is irradiated with light emitted from a light source, and the irradiated light is received by a spectrophotometer 4. Based on the amount of light received, a controller 21 calculates the concentration of a predetermined component contained in the sample.

[0029] A vacuum suction device 50 is connected to the cleaning mechanism 3, the A-side reagent probe cleaning tank 31, and the B-side reagent probe cleaning tank 32. The analyzed reaction liquid remaining in the reaction container 2 is sucked from the cleaning mechanism 3. In addition, the cleaning water used to clean the outer walls of the A-side reagent probe 22 and the B-side reagent probe 23 is sucked from the A-side reagent probe cleaning tank 31 and the B-side reagent probe cleaning tank 32.

[0030] 2 is a schematic diagram of an automatic analyzer including a reagent probe washing tank side suction unit 41 (first suction unit). The reagent probe washing tank side suction unit 41 has multiple independent suction systems. In this embodiment, the multiple independent suction systems include system A 35 and system B 36. System A 35 and system B 36 each have their own solenoid valve (a two-way solenoid valve in this embodiment), so that the suction state is controlled individually.

[0031] The A system 35 includes an A-side reagent probe washing tank 31, an A-side waste liquid bottle 80 (first vacuum bottle) which is a vacuum bottle, and an A-side two-way solenoid valve 101 (first suction solenoid valve). The A-side reagent probe washing tank 31 and the A-side waste liquid bottle 80 are connected by a tube 55, and the A-side waste liquid bottle 80 and the A-side two-way solenoid valve 101 are also connected by a tube 55.

[0032] The B system 36 includes a B-side reagent probe washing tank 32, a B-side waste liquid bottle 81 (first vacuum bottle) which is a vacuum bottle, and a B-side two-way solenoid valve 102 (first suction solenoid valve). The B-side reagent probe washing tank 32 and the B-side waste liquid bottle 81 are connected by a tube 55, and the B-side waste liquid bottle 81 and the B-side two-way solenoid valve 102 are also connected by a tube 55.

[0033] As described above, the tubes 55 connecting the components in the A system 35 and the B system 36 can have the same structure. In this case, the A system 35 and the B system 36 have the same or equivalent pressure loss during vacuum suction.

[0034] The A system 35 and the B system 36 join at a three-way branch 33 and are connected to a reagent probe washing tank side vacuum tank 87 (first vacuum tank) via a reagent probe washing tank side three-way solenoid valve 120. The reagent probe washing tank side vacuum tank 87 is connected to a reagent probe washing tank side vacuum pump 54 (first vacuum pump). The reagent probe washing tank side vacuum tank 87 is always kept in a low pressure state by the reagent probe washing tank side vacuum pump 54.

[0035] A reagent probe washing tank side pressure sensor 71 (first pressure sensor) is installed in the reagent probe washing tank side vacuum tank 87 to measure the pressure inside the reagent probe washing tank side vacuum tank 87 .

[0036] As described above, the automatic analyzer of this embodiment includes the reagent probe washing tank side vacuum pump 54, the reagent probe washing tank side vacuum tank 87 connected to the reagent probe washing tank side vacuum pump 54, the reagent probe washing tank side pressure sensor 71 installed in the reagent probe washing tank side vacuum tank 87, an A-side waste liquid bottle 80 and a B-side waste liquid bottle 81 connected to the reagent probe washing tank side vacuum tank 87, an A-side two-way solenoid valve 101 and a B-side two-way solenoid valve 102.

[0037] The cleaning liquid in the A-side reagent probe washing tank 31 is sucked in by utilizing the vacuum pressure from the reagent probe washing tank vacuum tank 87 when the reagent probe washing tank three-way solenoid valve 120 and the A-side two-way solenoid valve 101 are simultaneously opened. Similarly, the cleaning liquid in the B-side reagent probe washing tank 32 is sucked in by utilizing the vacuum pressure from the reagent probe washing tank vacuum tank 87 when the reagent probe washing tank three-way solenoid valve 120 and the B-side two-way solenoid valve 102 are simultaneously opened.

[0038] In this manner, the reagent probe washing tank side vacuum tank 87 sucks the liquid inside the A-side reagent probe washing tank 31 and the B-side reagent probe washing tank 32, each of which contains liquid.

[0039] The A-side two-way solenoid valve 101 is installed between the reagent probe washing tank side vacuum tank 87 and the A-side waste liquid bottle 80, and adjusts the suction pressure by opening and closing when the reagent probe washing tank side vacuum tank 87 sucks liquid. Similarly, the B-side two-way solenoid valve 102 is installed between the reagent probe washing tank side vacuum tank 87 and the B-side waste liquid bottle 81, and adjusts the suction pressure by opening and closing when the reagent probe washing tank side vacuum tank 87 sucks liquid.

[0040] The A-side waste liquid bottle 80 and the B-side waste liquid bottle 81 are containers for storing the aspirated cleaning liquid. That is, the A-side waste liquid bottle 80 and the B-side waste liquid bottle 81 serve to prevent liquid from entering the reagent probe cleaning tank side vacuum tank 87.

[0041] It is also possible to discharge liquid from the A-side waste liquid bottle 80 and the B-side waste liquid bottle 81 via the A-side waste liquid two-way solenoid valve 84 and the B-side waste liquid two-way solenoid valve 85, respectively.

[0042] The automatic analyzer includes a controller 21. The controller 21 is, for example, configured by a computer. The computer has, for example, a hardware configuration as a known computer, and includes, for example, a calculation means and a storage means. The calculation means includes, for example, a processor, and the storage means includes, for example, a storage medium such as a semiconductor memory device and a magnetic disk device. The storage means may store a program. The processor may execute this program, causing the computer to execute the functions described in this embodiment.

[0043] The controller 21 is connected to each mechanism of the automatic analyzer and controls the operation of the automatic analyzer. The controller 21 functions as a control unit.

[0044] The signal output by the reagent probe washing tank side pressure sensor 71 is input to a determination unit 103. The determination unit 103 includes a sampling unit 104 and a storage unit 105. The determination unit 103 outputs information to a display unit .

[0045] FIG. 3 is a diagram showing the reagent probe washing tank side suction unit 41 (first suction unit) and the reaction container side suction unit 42 (second suction unit) of FIG. 2 in the automatic analyzer.

[0046] As described above, the reagent probe washing tank side suction unit 41 is connected to the reagent probe washing tank side vacuum pump 54 and the reagent probe washing tank side vacuum tank 87. In addition, the reaction container side suction unit 42 is connected to the reaction container side vacuum pump 53 (second vacuum pump) and the reaction container side vacuum tank 88 (second vacuum tank). In this way, by providing each suction unit with its own vacuum pump and vacuum tank, vacuum suction can be performed independently of each other.

[0047] Here, the reagent probe washing tank side vacuum pump 54 and the reaction vessel side vacuum pump 53 may be vacuum pumps of different configurations, or a single parallel vacuum pump in which vacuum pumps of different configurations are arranged in parallel may be used. Also, vacuum pumps of the same configuration may be used, or a single parallel vacuum pump in which vacuum pumps of the same configuration are arranged in parallel may be used.

[0048] The reagent probe washing tank side vacuum tank 87 and the reaction vessel side vacuum tank 88 may be vacuum tanks of different shapes or may be vacuum tanks of the same shape. Also, a single vacuum tank may be divided into two by providing a partition inside the tank so that the tank functions as two vacuum tanks.

[0049] Reaction vessel side suction unit 42 includes reaction vessel 2, cleaning mechanism 3, and suction nozzles 13a, 13b, 13c, and 13d (a single suction nozzle 13 is shown in FIG. 1). Suction nozzles 13a, 13b, 13c, and 13d provided on cleaning mechanism 3 are connected via tube 55 to reaction vessel side waste liquid bottle 83 (second vacuum bottle), which is a vacuum bottle, reaction vessel side three-way solenoid valve 121 (second solenoid valve for suction), reaction vessel side vacuum tank 88, and reaction vessel side vacuum pump 53.

[0050] When the analyzed reaction liquid is to be aspirated, the reaction vessel-side three-way solenoid valve 121 opens, and the analyzed reaction liquid is aspirated from the reaction vessel 2 by utilizing the vacuum pressure from the reaction vessel-side vacuum tank 88. Meanwhile, the reaction vessel-side waste liquid bottle 83 is a container for storing the aspirated analyzed reaction liquid. In other words, the reaction vessel-side waste liquid bottle 83 plays a role in preventing the analyzed reaction liquid from entering the reaction vessel-side vacuum tank 88.

[0051] It is also possible to discharge liquid from the reaction vessel side waste liquid bottle 83 via a two-way electromagnetic valve 86 for reaction vessel side waste liquid.

[0052] A reaction vessel side pressure sensor 72 (second pressure sensor) is installed in the reaction vessel side vacuum tank 88 and measures the pressure inside the reaction vessel side vacuum tank 88. A signal output from the reaction vessel side pressure sensor 72 is input to a determination unit 103.

[0053] As described above, the automatic analyzer of this embodiment includes the reaction vessel side vacuum pump 53, the reaction vessel side vacuum tank 88 connected to the reaction vessel side vacuum pump 53, the reaction vessel side pressure sensor 72 installed in the reaction vessel side vacuum tank 88, the reaction vessel side waste liquid bottle 83 connected to the reaction vessel side vacuum tank 88, and the reaction vessel side three-way solenoid valve 121.

[0054] FIG. 4 shows the opening and closing operations of the reagent probe washing tank side three-way solenoid valve 120, the A-side two-way solenoid valve 101, and the B-side two-way solenoid valve .

[0055] The cleaning water in the A-side reagent probe washing tank 31 is sucked in when the reagent probe washing tank side three-way solenoid valve 120 and the A-side two-way solenoid valve 101 are simultaneously opened. Similarly, the cleaning water in the B-side reagent probe washing tank 32 is sucked in when the reagent probe washing tank side three-way solenoid valve 120 and the B-side two-way solenoid valve 102 are simultaneously opened.

[0056] In FIG. 4, the cycle switching is indicated by the dashed lines. The reagent probe washing tank side three-way solenoid valve 120 opens once per cycle. On the other hand, the A-side two-way solenoid valve 101 and the B-side two-way solenoid valve 102 open once every two cycles, and the opening timing alternates. During a part of a cycle, both the reagent probe washing tank side three-way solenoid valve 120 and the A-side two-way solenoid valve 101 open, and during another part of the cycle, one or both are closed. During a part of the next cycle, both the reagent probe washing tank side three-way solenoid valve 120 and the B-side two-way solenoid valve 102 open, and during another part of the cycle, one or both are closed. In this way, the A-side reagent probe washing tank 31 and the B-side reagent probe washing tank 32 alternately aspirate the washing solution once every two cycles.

[0057] 5A shows pressure fluctuations in the vacuum tank 87 on the reagent probe washing tank side when the solenoid valve operation shown in Fig. 4 is performed and the cleaning solution is normally suctioned from the A-side reagent probe washing tank 31 and the B-side reagent probe washing tank 32. The horizontal axis represents time, and the vertical axis represents relative pressure with atmospheric pressure set to 0.

[0058] In Figure 5A, the dashed lines indicate the timing when the cleaning solution for the A-side reagent probe cleaning tank 31 is aspirated when both the reagent probe cleaning tank side three-way solenoid valve 120 and the A-side two-way solenoid valve 101 are open, and the solid lines indicate the timing when the cleaning solution for the B-side reagent probe cleaning tank 32 is aspirated when both the reagent probe cleaning tank side three-way solenoid valve 120 and the B-side two-way solenoid valve 102 are open.

[0059] As shown in FIG. 5A, the pressure decreases in the area other than the area indicated by the dashed and solid lines, and the pressure increases in the area indicated by the dashed and solid lines.

[0060] In sections other than those indicated by the dashed and solid lines, the reagent probe washing tank side three-way solenoid valve 120 is closed, or both the A-side two-way solenoid valve 101 and the B-side two-way solenoid valve 102 are closed. Therefore, there is no communication between the A-side reagent probe washing tank 31 or the B-side reagent probe washing tank 32 and the reagent probe washing tank side vacuum tank 87. At this time, the reagent probe washing tank side vacuum pump 54 sucks the reagent probe washing tank side vacuum tank 87, so that the pressure in the reagent probe washing tank side vacuum tank 87 drops. Therefore, the pressure is minimum at the end of this section (i.e., the start of the dashed line section and the start of the solid line section).

[0061] The dashed and solid line sections are sections where the reagent probe washing tank side three-way solenoid valve 120 and the A-side two-way solenoid valve 101 or the B-side two-way solenoid valve 102 are open. Therefore, the A-side reagent probe washing tank 31 or the B-side reagent probe washing tank 32 communicates with the reagent probe washing tank side vacuum tank 87 via piping.

[0062] In this section, air flows from the A-side reagent probe washing tank 31 or the B-side reagent probe washing tank 32, which has a higher pressure than the reagent probe washing tank vacuum tank 87, to the reagent probe washing tank vacuum tank 87, which has a lower pressure. In other words, the washing water in the A-side reagent probe washing tank 31 or the B-side reagent probe washing tank 32 is sucked into the piping. At this time, the pressure in the reagent probe washing tank vacuum tank 87 increases. Therefore, the pressure reaches a maximum at the end of the section indicated by the dashed and solid lines.

[0063] If the A system 35 and the B system 36 have the same structure, the pressure rise value in the dashed line section and the solid line section will be approximately the same. Also, the pressure drop value in the non-dashed line section and the non-solid line section will be approximately the same.

[0064] Fig. 5B is a graph extracting the maximum value for each cycle of Fig. 5A. As shown in Fig. 5B, the maximum pressure of the reagent probe washing tank side vacuum tank 87 shows almost the same value for each cycle. That is, the pressure Pa at the end of suction of the A system 35 is constant or almost constant regardless of the cycle, and the pressure Pb at the end of suction of the B system 36 is also constant or almost constant regardless of the cycle.

[0065] The fluctuation range of the pressure measurement value due to the operation of the A-side two-way solenoid valve 101 in the A system 35 (i.e., the difference between the maximum value and the minimum value) is denoted as ΔPa. Moreover, the fluctuation range of the pressure measurement value due to the operation of the B-side two-way solenoid valve 102 in the B system 36 (i.e., the difference between the maximum value and the minimum value) is denoted as ΔPb. The difference between these fluctuation ranges, i.e., ΔPa-ΔPb (strictly speaking, the absolute value of the difference), is 0 in the example of Fig. 5B, and is equal to or less than a predetermined threshold value TH1 (first threshold value) under normal conditions.

[0066] FIG. 6A shows the pressure fluctuation in the reagent probe washing tank side vacuum tank 87 when an abnormality occurs in which the B-side two-way solenoid valve 102 does not close, and FIG. 6B shows a graph in which the maximum value for each cycle of FIG. 6A is extracted.

[0067] Figures 6A and 6B show the pressure fluctuations not only during abnormal times (black squares) but also during normal times (white circles). As shown in Figures 6A and 6B, during normal times (white circles), the pressure fluctuations were the same for all cycles and Pa = Pb. However, during abnormal times (black squares), Pa > Pb.

[0068] The reason for this is that if the B-side two-way solenoid valve 102 does not close, it means that the B-side two-way solenoid valve 102 is always open. That is, at the timing when the A-side two-way solenoid valve 101 opens, both the A-side two-way solenoid valve 101 and the B-side two-way solenoid valve 102 are open. Therefore, at the timing when the A-side two-way solenoid valve 101 opens, the cleaning liquid is sucked from both the A-side reagent probe cleaning tank 31 and the B-side reagent probe cleaning tank 32, and the pressure increase value becomes large.

[0069] On the other hand, at the timing when the B-side two-way solenoid valve 102 opens, only the B-side two-way solenoid valve 102 is open. Therefore, at the timing when the B-side two-way solenoid valve 102 opens, only the B-side reagent probe cleaning tank 32 is sucked, and the pressure increase value becomes small.

[0070] Therefore, when Pa > Pb, the possibility of an abnormality that the B-side two-way solenoid valve 102 does not close can be predicted. Conversely, when Pa < Pb, the possibility of an abnormality that the A-side two-way solenoid valve 101 is not closed can be predicted.

[0071] Also, the difference ΔPa - ΔPb in the fluctuation range of the pressure measurement values due to the operations of the A-side two-way solenoid valve 101 and the B-side two-way solenoid valve 102 in the A system 35 and the B system 36 is not zero. When this difference is equal to or greater than a predetermined threshold value TH2 (second threshold value), the possibility of an abnormality in the automatic analyzer (for example, an abnormality in the A system 35 or the B system 36) can be predicted. By appropriately setting the first threshold value, an abnormality can be appropriately detected. When there are three or more suction systems, the difference between the maximum value and the minimum value of the fluctuation range of the pressure measurement values can be used.

[0072] 7 is a chart for detecting an abnormality in the reagent probe washing tank side suction unit 41. First, the controller 21 closes the reagent probe washing tank side three-way solenoid valve 120, the A-side two-way solenoid valve 101, and the B-side two-way solenoid valve 102 (201).

[0073] Next, the controller 21 starts the operation of the reagent probe washing tank side vacuum pump 54. At this time, since all the solenoid valves are closed, the pressure in the reagent probe washing tank side vacuum tank 87 decreases to a certain value (202).

[0074] Next, the controller 21 starts measuring the pressure of the reagent probe washing tank side vacuum tank 87 (203).

[0075] Thereafter, the controller 21 starts the analysis operation (204). For example, the controller 21 controls the opening and closing of the A-side two-way solenoid valve 101 and the B-side two-way solenoid valve 102. Accordingly, a cycle including the supply of liquid to the A-side reagent probe washing tank 31 and the B-side reagent probe washing tank 32 and the vacuum suction operation is started. The pressure at this time changes, for example, as shown in FIG. 5A or FIG. 6A.

[0076] In the i-th cycle (where i is the cycle number), the determination unit 103 acquires the maximum value Pa of the pressure measurement value in the cycle in which the A-side two-way solenoid valve 101 opens (205). Next, the determination unit 103 acquires the maximum value Pb of the pressure measurement value in the cycle in which the B-side two-way solenoid valve 102 opens (i.e., the (i+1)th cycle) (206).

[0077] The determination unit 103 calculates ΔP=Pa−Pb (207), and determines whether or not there is an abnormality (208).

[0078] If ΔP is within a preset normal range, the judgment unit 103 judges that "there is no abnormality in the automatic analyzer" (209). For example, it is judged that there is no abnormality in the A system 35 and the B system 36. On the other hand, if ΔP is outside the normal range, the judgment unit 103 judges that "there is an abnormality in the automatic analyzer" (210). For example, it is judged that there is an abnormality in the A system 35 or the B system 36.

[0079] When an abnormality in the automatic analyzer is detected (210), the determination unit 103 outputs information indicating that there is an abnormality in the automatic analyzer. For example, the determination unit 103 outputs information indicating that an abnormality may have occurred due to a malfunction of the A-side two-way solenoid valve 101 or the B-side two-way solenoid valve 102 opening and closing, a reduction in the inner diameter of a pipe in the automatic analyzer, or a break in a pipe in the automatic analyzer. The manner of output can be designed arbitrarily, and is realized, for example, by display on a display device and / or storage in a storage medium. By outputting the information, the user of the automatic analyzer can be informed of the possibility of an abnormality occurring.

[0080] In this way, the determination unit 103 detects an abnormality in the automatic analyzer based on the pressure measurement value of the reagent probe washing tank side vacuum tank 87 measured by the reagent probe washing tank side pressure sensor 71. In particular, the determination unit 103 detects an abnormality in the automatic analyzer by comparing the pressure measurement values ​​during suction related to the A system 35 and the B system 36.

[0081] 7, the determination unit 103 may detect the abnormality of the automatic analyzer as an abnormality in one of the suction systems (for example, system A 35 or system B 36). In other words, when the determination unit 103 detects an abnormality in the automatic analyzer, it may output information indicating that an abnormality may have occurred in one of the suction systems. In this way, the user of the automatic analyzer can know in more detail the location where the abnormality has occurred.

[0082] For example, when the determination unit 103 determines that there is an abnormality in the automatic analyzer, if Pa > Pb, it may output information indicating that there may be an abnormality that the B-side two-way solenoid valve 102 does not close. Conversely, if Pa < Pb, it may output information indicating that there may be an abnormality that the A-side two-way solenoid valve 101 does not close.

[0083] In this embodiment, the determination unit 103 detects an abnormality based on the pressure measurement value during the analysis operation by the automatic analyzer. Therefore, it is possible to detect an abnormality without stopping the analysis operation.

[0084] In this embodiment, the determination unit 103 detects an abnormality in the automatic analyzer (for example, a vacuum suction pipe) based on ΔP (= Pa - Pb). That is, on the same day, an abnormality is determined based on the pressure values of the same pump. In this way, by detecting an abnormality based on ΔP calculated from consecutive cycles, it is possible to eliminate the daily difference and individual difference of the pump, and abnormality detection can be performed without reducing the accuracy.

[0085] Note that factors affecting the performance of the vacuum pump such as atmospheric pressure and temperature may be measured using a barometer, thermometer, etc., and the daily difference of the vacuum pump may be eliminated from the measurement values. Also, the individual difference of the vacuum pump may be grasped in advance and the individual difference of the vacuum pump may be eliminated.

[0086] Also, the daily difference of the vacuum pump may be eliminated based on the pressure measurement values of different suction units. For example, the state of the pump on that day may be grasped from the pressure measurement value of the vacuum tank 87 on the reagent probe washing tank side, and the pressure measurement value of the vacuum tank 88 on the reaction vessel side may be corrected.

[0087] Also, in this embodiment, an abnormality is detected from the pressure measurement value (for example, the maximum value) at a specific time during each cycle. That is, if pressure measurement data at at least one time per cycle is acquired, an abnormality can be detected. Therefore, an abnormality can be detected with a small amount of data.

[0088] Moreover, the pressure can be measured only by the reagent probe washing tank side pressure sensor 71. In other words, there is no need to install a pressure sensor for each system, which allows the device to be made smaller and less expensive.

[0089] In a modified example, the determination unit 103 may determine that an abnormality in the automatic analyzer has not been detected if the difference ΔPa-ΔPb in the fluctuation range of the pressure measurement values ​​is equal to or less than the threshold value TH2. For example, it is determined that there is no abnormality in the A system 35 and the B system 36. On the other hand, the determination unit 103 may determine that an abnormality in the automatic analyzer has been detected if ΔPa-ΔPb exceeds the threshold value TH2. For example, it is determined that there is an abnormality in the A system 35 or the B system 36. By using the difference in the fluctuation range in this way, a determination can be made that takes into account both the maximum value and the minimum value.

[0090] In the first embodiment, the determination unit 103 detects an abnormality in the automatic analyzer by comparing pressure measurement values ​​at the time when the pressure in the reagent probe washing tank side vacuum tank 87 is at its maximum. As a modified example, the determination unit 103 may detect an abnormality in the automatic analyzer by comparing pressure measurement values ​​at the time when the pressure in the reagent probe washing tank side vacuum tank 87 is at its minimum. When the maximum or minimum value is used, the detection accuracy is not affected even if there is a slight time lag in the cycle.

[0091] In another modified example, the determination unit 103 may detect an abnormality in the automatic analyzer by comparing pressure measurement values ​​at a predetermined time during the operation cycle of the A-side two-way solenoid valve 101 and the B-side two-way solenoid valve 102. For example, as shown in Fig. 5A, the pressure measurement value at time t during each cycle may be used. Using the measurement value at the predetermined time makes it possible to detect an abnormality when a time lag occurs in the cycle.

[0092] In the first embodiment (FIG. 7), the process ends after step 209 or 210, but as a modified example, the process may return to step 205 after step 209 or 210. In this way, the determination is made continuously in each cycle.

[0093] In the first embodiment, the determination unit 103 detects an abnormality in relation to the reagent probe washing tank side vacuum tank 87 (for example, based on the pressure measurement value thereof). In a modified example, as shown in Fig. 7, after step 209 or 210, the determination unit 103 may detect an abnormality in the automatic analyzer individually in relation to the reaction vessel side vacuum tank 88 (for example, based on the pressure measurement value thereof). In this way, by detecting an abnormality in the automatic analyzer individually in relation to the reagent probe washing tank side vacuum tank 87 and the reaction vessel side vacuum tank 88, the range of abnormalities that can be detected is widened.

[0094] A method for detecting an abnormality in relation to the reaction vessel side vacuum tank 88 can be appropriately designed by a person skilled in the art. For example, a known abnormality detection method may be used. Also, for example, separate suction systems may be provided between each of the suction nozzles 13a, 13b, 13c, and 13d and the reaction vessel side vacuum tank 88, and a configuration may be provided with a plurality of suction systems like the reagent probe washing tank side suction unit 41 of the first embodiment. In that case, the same abnormality detection method as that for the reagent probe washing tank side vacuum tank 87 of the first embodiment can also be implemented for the reaction vessel side vacuum tank 88.

[0095] Fig. 8A shows pressure fluctuations in the reagent probe washing tank side vacuum tank 87 when an abnormality occurs in which the B-side two-way solenoid valve 102 does not open. Fig. 8B is a graph showing maximum values ​​extracted for each cycle in Fig. 8A.

[0096] As shown in FIGS. 8A and 8B, during normal operation (white circles), the pressure fluctuations were the same in all cycles and Pa = Pb. However, during abnormal operation (black squares), the pressure increased and decreased differently every other cycle, resulting in Pa > Pb. The reason for this is that when the B-side two-way solenoid valve 102 does not open, it means that at the timing when the B-side two-way solenoid valve 102 should open, both the A-side two-way solenoid valve 101 and the B-side two-way solenoid valve 102 are closed. Therefore, the reagent probe cleaning tank side vacuum pump 54 sucks the reagent probe cleaning tank side vacuum tank 87, and the pressure of the reagent probe cleaning tank side vacuum tank 87 decreases. On the other hand, at the timing when the A-side two-way solenoid valve 101 opens, the A-side two-way solenoid valve 101 opens while the B-side two-way solenoid valve 102 is closed. Therefore, at the timing when the A-side two-way solenoid valve 101 opens, the cleaning tank 31 for the A-side reagent probe is being sucked, and the pressure increases.

[0097] Therefore, when Pa > Pb, it is possible to predict the abnormality that the B-side two-way solenoid valve 102 does not open. Conversely, when Pa < Pb, it is possible to predict the abnormality that the A-side two-way solenoid valve 101 does not open. For this reason, when an abnormality is detected, the user of the automatic analyzer can obtain more detailed information by checking the status of the pressure fluctuations during the cycle.

[0098] For example, when the determination unit 103 determines that there is an abnormality in the automatic analyzer, if Pa > Pb, it may output information indicating that there may be an abnormality that the B-side two-way solenoid valve 102 does not open. Conversely, if Pa < Pb, it may output information indicating that there may be an abnormality that the A-side two-way solenoid valve 101 does not open.

[0099] FIG. 9A shows the pressure fluctuations of the reagent probe cleaning tank side vacuum tank 87 when an abnormality occurs where a part of the B-side reagent probe cleaning tank side vacuum suction flow path (for example, between the B-side waste liquid bottle 81 and the B-side two-way solenoid valve 102) is blocked. FIG. 9B shows a graph obtained by extracting the maximum value of each cycle in FIG. 9A.

[0100] As shown in FIGS. 9A and 9B, under normal conditions, the pressure fluctuations were the same in all cycles and Pa = Pb. In the event of an abnormality, the pressure rise and fall differed every other cycle, and Pa > Pb. The reason for this is that if there is a blockage in the B-side vacuum suction channel, it means that suction cannot be performed from the B-side vacuum suction channel. Therefore, at the timing when the B-side two-way solenoid valve 102 opens, the pressure rise value becomes small. Thus, when Pa > Pb, the possibility of an abnormality such as a blockage in the B-side vacuum suction channel can be predicted. For this reason, when an abnormality is detected, the user of the automatic analyzer can obtain more detailed information by checking the status of the pressure fluctuations during the cycle.

[0101] For example, when the determination unit 103 determines that there is an abnormality in the automatic analyzer, if Pa > Pb, it may output information indicating that there may be a blockage in the B system 36. Conversely, if Pa < Pb, it may output information indicating that there may be a blockage in the A system 35.

[0102] FIG. 10A shows the pressure fluctuations of the vacuum tank 87 on the reagent probe cleaning tank side when an abnormality occurs where air leaks from a part of the vacuum suction channel on the cleaning tank side of the B-side reagent probe (for example, between the B-side waste liquid bottle 81 and the B-side two-way solenoid valve 102). FIG. 10B shows a graph in which the maximum value of each cycle in FIG. 10A is extracted.

[0103] As shown in FIGS. 10A and 10B, under normal conditions, the pressure fluctuations were the same in all cycles and Pa = Pb. In the event of an abnormality, the pressure rise and fall differed every other cycle, and Pa < Pb. The reason for this is that due to a leak in the B-side vacuum suction channel, air rather than liquid is sucked from the leak point. Since air has a lower density compared to liquid, the pressure loss is small. Therefore, at the timing when the B-side two-way solenoid valve 102 opens, the pressure rise value becomes large. Thus, when Pa < Pb, the possibility of an abnormality such as a leak point in the B-side vacuum suction channel can be predicted. For this reason, when an abnormality is detected, the user of the automatic analyzer can obtain more detailed information by checking the status of the pressure fluctuations during the cycle.

[0104] For example, when the determination unit 103 determines that there is an abnormality in the automatic analyzer, if Pa < Pb, it may output information indicating that there may be a leak in the B system 36. Conversely, if Pa > Pb, it may output information indicating that there may be a leak in the A system 35.

Example

[0105] Hereinafter, a second embodiment of the present invention will be described with reference to FIGS. 11, 12A, 12B, and 13. In FIGS. 11, 12A, 12B, and 13, the same reference numerals as those in FIGS. 1 to 10 denote the same components, and repeated descriptions may be omitted. Also, descriptions of the same parts as those in the first embodiment may be omitted.

[0106] The automatic analyzer according to the second embodiment includes a liquid supply unit 123 in addition to the configuration of the first embodiment.

[0107] FIG. 11 is a diagram showing a reagent probe cleaning tank side suction unit 41, a reaction vessel side suction unit 42, and a liquid supply unit 123 of the second embodiment. The liquid supply unit 123 includes a water supply tank 111, a water supply pump 112, a gear pump 113, a branch pipe 122, a tube 55, water supply two-way solenoid valves 114a to 114f (water supply solenoid valves), and water supply probes 115a to 115d.

[0108] The water supply pump 112 is installed to supply liquid to the pipe, and the water supply tank 111 stores the liquid and supplies the liquid to the water supply pump 112. The gear pump 113 applies pressure to the pipe.

[0109] The branch pipe 122 branches the pipe to supply liquid individually to the reaction vessels 2 (2a to 2d), the A-side reagent probe cleaning tank 31, and the B-side reagent probe cleaning tank 32.

[0110] The water supply two-way solenoid valves 114a, 114b, 114c, and 114d individually control the timing of supplying liquid to the reaction vessels 2a, 2b, 2c, and 2d. The water supply two-way solenoid valves 114e and 114f individually control the timing of supplying liquid to the A-side reagent probe washing tank 31 and the B-side reagent probe washing tank 32. The water supply probes 115a, 115b, 115c, and 115d discharge liquid to each of the reaction vessels 2a, 2b, 2c, and 2d. The water supply two-way solenoid valves 114a to 114f are connected to the controller 21 and are operationally controlled by the controller 21.

[0111] Thus, the automatic analyzer according to the second embodiment includes a liquid supply unit 123 and a plurality of water supply two-way electromagnetic valves 114a to 114f. The liquid supply unit 123 also includes a water supply pump 112 for supplying liquid, a water supply tank 111 for supplying liquid to the water supply pump 112, and a gear pump 113 for applying pressure to the liquid.

[0112] The two-way water supply solenoid valves 114a to 114f are respectively installed between the gear pump 113 and the reaction container 2, the washing tank 31 for the A-side reagent probe, or the washing tank 32 for the B-side reagent probe, and adjust the supply pressure by opening and closing when the liquid supply unit 123 supplies liquid.

[0113] Fig. 12A shows the pressure fluctuation of the reagent probe washing tank side vacuum tank 87 when an abnormality occurs in the liquid supply to the B-side reagent probe washing tank 32, and Fig. 12B shows a graph extracting the maximum values ​​for each cycle of Fig. 12A. The white sections in Fig. 12A show the timing when the reagent probe washing tank side three-way solenoid valve 120 and the A-side two-way solenoid valve 101 open simultaneously, and the shaded sections show the timing when the reagent probe washing tank side three-way solenoid valve 120 and the B-side two-way solenoid valve 102 open simultaneously.

[0114] 12A and 12B, under normal conditions, the pressure fluctuations are equal in all cycles, and Pa = Pb. This is because system A 35 and system B 36 have the same structure, so the pressure rise values ​​in the white rectangle section and the shaded rectangle section are approximately equal to the pressure drop values ​​outside these sections.

[0115] On the other hand, during abnormal times, the pressure increase and decrease are different every cycle, and Pa < Pb. This is because when an abnormality occurs in the liquid supply to the cleaning tank 32 for the B-side reagent probe, the liquid is not supplied to the cleaning tank 32 for the B-side reagent probe. Therefore, the vacuum suction channel sucks the air present in the cleaning tank 32 for the B-side reagent probe. As a result, the pressure loss during suction of the cleaning tank 32 for the B-side reagent probe becomes smaller. For this reason, the pressure fluctuation during suction of the cleaning tank 32 for the B-side reagent probe becomes larger than the pressure fluctuation during suction of the cleaning tank 31 for the A-side reagent probe.

[0116] Therefore, when Pa > Pb, it can be predicted that there is a possibility that an abnormality has occurred in the liquid supply channel on the B side.

[0117] Figure 13 is a chart for detecting abnormalities in the suction unit 41 on the cleaning tank side of the reagent probe and the liquid supply unit 123. As shown in Figure 13, first, the controller 21 closes all of the three-way solenoid valve 120 on the cleaning tank side of the reagent probe, the two-way solenoid valve 101 on the A side, the two-way solenoid valve 102 on the B side, and the two-way solenoid valves 114a to 114f for water supply (220).

[0118] Next, the controller 21 starts the operation of the vacuum pump 54 on the cleaning tank side of the reagent probe, the water supply pump 112, and the gear pump 113. Since all the solenoid valves are closed, the pressure in the vacuum tank 87 on the cleaning tank side of the reagent probe decreases until it reaches a certain value (221).

[0119] Subsequently, the controller 21 starts measuring the pressure in the vacuum tank 87 on the cleaning tank side of the reagent probe (222).

[0120] After that, the controller 21 starts the analysis operation (223). For example, the controller 21 controls the opening and closing of the A-side two-way solenoid valve 101 and the B-side two-way solenoid valve 102, and the water supply two-way solenoid valves 114a to 114f. Along with this, a cycle including liquid supply to the reaction vessel 2, the A-side reagent probe cleaning tank 31, and the B-side reagent probe cleaning tank 32, and a vacuum suction operation is started. The pressure at this time changes as shown in, for example, FIG. 12A.

[0121] In the i-th cycle (where i is the cycle number), the determination unit 103 acquires the maximum value Pa of the pressure measurement value in the cycle when the A-side two-way solenoid valve 101 opens (224). Subsequently, the determination unit 103 acquires the maximum value Pb of the pressure measurement value in the cycle when the B-side two-way solenoid valve 102 opens (i.e., the (i + 1)-th cycle) (225).

[0122] The determination unit 103 calculates ΔP = Pa - Pb (226) and determines whether there is an abnormality (227).

[0123] If ΔP is within the preset normal value range, the determination unit 103 determines that "there is no abnormality in the automatic analyzer" (228). For example, it is determined that there is no abnormality in the A system 35, the B system 36, and the reagent probe cleaning tank side suction unit 41. On the other hand, if ΔP is outside the normal value range, the determination unit 103 determines that "there is an abnormality in the automatic analyzer" (229). For example, it is determined that there is an abnormality in the A system 35, the B system 36, or the reagent probe cleaning tank side suction unit 41.

[0124] For example, when the determination unit 103 determines that there is an abnormality in the automatic analyzer, if Pa < Pb, it may output information indicating that there may be an abnormality in the liquid supply path of the B system 36, and conversely, if Pa > Pb, it may output information indicating that there may be an abnormality in the liquid supply path of the A system 35.

[0125] In this embodiment, in addition to the components of embodiment 1, a liquid supply unit 123 is provided. In embodiment 1, only abnormalities in A system 35 or B system 36 were detected. In this embodiment, there is an advantage that an abnormality in liquid supply unit 123 can also be detected based on the pressure measurement value of reagent probe washing tank side vacuum tank 87. EXAMPLES

[0126] Next, a third embodiment of the present invention will be described with reference to Figures 14, 15A, 15B, 16A, 16B, and 17. In Figures 14, 15A, 15B, 16A, 16B, and 17, the same reference numerals as in Figures 1 to 13 indicate the same parts, and therefore repeated description will be omitted. In the third embodiment, a difference from the second embodiment is that the liquid supply unit 123 of the second embodiment detects an abnormality in the liquid supply on the reaction vessel side. Hereinafter, description of the same parts as in the second embodiment may be omitted.

[0127] FIG. 14 shows the opening and closing operations of the water supply two-way solenoid valves 114a to 114d and the reaction vessel side three-way solenoid valve 121.

[0128] First, the water supply two-way solenoid valve 114a opens to supply water to the reaction vessel 2a. After the water supply to the reaction vessel 2a is completed, the water supply two-way solenoid valve 114a closes. Next, the reaction vessel side three-way solenoid valve 121 opens to suck in the water from the reaction vessel 2a. After the reaction vessel side three-way solenoid valve 121 closes, the water supply two-way solenoid valve 114b opens to supply water to the reaction vessel 2b. After the water supply to the reaction vessel 2b is completed, the water supply two-way solenoid valve 114b closes. Next, the reaction vessel side three-way solenoid valve 121 opens to suck in the water from the reaction vessel 2b. The same operation is performed for the reaction vessel 2c and the reaction vessel 2d.

[0129] Figure 15A shows the pressure fluctuations in the vacuum tank 88 on the reaction vessel side when the solenoid valve operation shown in Figure 14 is performed, there is no abnormality in the water supply flow path on the reaction vessel side, water is supplied normally to the reaction vessel 2, and cleaning liquid is suctioned normally from within the reaction vessel 2.

[0130] In FIG. 15A, the section in which the liquid in the reaction vessel 2 is sucked by opening the reaction vessel side three-way electromagnetic valve 121 is shown by a broken line.

[0131] As shown in Fig. 15A, the pressure rises and reaches a maximum value within the dashed line section, and drops and reaches a minimum value outside the dashed line section. The reason for this is that outside the dashed line section, the reaction vessel side three-way solenoid valve 121 is closed, and there is no communication between the reaction vessel 2 and the reaction vessel side vacuum tank 88. At this time, the reaction vessel side vacuum pump 53 sucks the reaction vessel side vacuum tank 88, so the pressure in the reaction vessel side vacuum tank 88 drops. Therefore, the pressure reaches a minimum at the end of the section where the reaction vessel side three-way solenoid valve 121 is closed (i.e., the start of the dashed line section).

[0132] In the dashed line section, the reaction vessel-side three-way solenoid valve 121 is open, and the reaction vessel 2 and the reaction vessel-side vacuum tank 88 are in communication. In this state, fluid flows from the reaction vessel 2, which has a higher pressure than the reaction vessel-side vacuum tank 88, to the reaction vessel-side vacuum tank 88, which has a lower pressure. Due to this phenomenon, the pressure in the reaction vessel-side vacuum tank 88 rises while the reaction vessel-side three-way solenoid valve 121 is open. Therefore, the pressure reaches its maximum at the end of the section (dashed line section) in which the reaction vessel-side three-way solenoid valve 121 is open.

[0133] Fig. 15B is a graph in which the maximum values ​​for each cycle of Fig. 15A are extracted. As shown in Fig. 15B, under normal conditions, the maximum pressure of the reaction vessel side vacuum tank 88 shows approximately the same value for each cycle.

[0134] Fig. 16A shows pressure fluctuations in the reaction vessel side vacuum tank 88 when the solenoid valve operation shown in Fig. 14 is performed and an abnormality occurs in the water supply flow path of the reaction vessel 2d. Fig. 16B shows a graph in which the maximum values ​​of each cycle in Fig. 16A are extracted.

[0135] As shown in Fig. 16A, during normal operation, the pressure fluctuations are equivalent in all cycles. Let the maximum values of the pressure measurement values in the cycles when the two-way solenoid valves 114a, 114b, 114c, and 114d for water supply are open be Pa, Pb, Pc, and Pd respectively, then Pa = Pb = Pc = Pd.

[0136] On the other hand, during abnormal operation, this relationship may not hold. For example, when an abnormality occurs in the liquid supply to the reaction vessel 2d, the pressure increase and decrease in the reaction vessel 2d are different, and as shown in Fig. 16B, Pa = Pb = Pc < Pd. The reason for this is that when an abnormality occurs in the liquid supply to the reaction vessel 2d, no liquid is supplied to the reaction vessel 2d, and air is sucked instead of liquid, so the pressure loss during the suction of the reaction vessel 2d becomes smaller. Therefore, the pressure fluctuation during the suction of the reaction vessel 2d becomes larger than the pressure fluctuations during the suction of the reaction vessels 2a, 2b, and 2c.

[0137] Therefore, when Pa = Pb = Pc < Pd, it is possible to predict the abnormality that the liquid supply by the liquid supply unit 123 to the reaction vessel 2d is not being performed.

[0138] Fig. 17 is a chart for abnormality detection of the reaction vessel side suction unit 42. First, the controller 21 closes the three-way solenoid valve 121 on the reaction vessel side (300).

[0139] Next, the controller 21 starts the operation of the reaction vessel side vacuum pump 53. At this time, since the three-way solenoid valve 121 on the reaction vessel side is closed, the pressure in the reaction vessel side vacuum tank 88 decreases until it reaches a certain value (301).

[0140] Subsequently, the controller 21 starts measuring the pressure of the reaction vessel side vacuum tank 88 (302).

[0141] Thereafter, the controller 21 starts a water discharge check operation (303). For example, the controller 21 controls the opening and closing of the water supply two-way solenoid valves 114a to 114d. Accordingly, a cycle including liquid supply to the reaction vessels 2a to 2d and a vacuum suction operation is started. The pressure at this time changes, for example, as shown in FIG. 15A or FIG. 16A.

[0142] In the i-th cycle (where i is the cycle number), the judgment unit 103 acquires the maximum pressure measurement value Pa in the cycle in which the water supply two-way solenoid valve 114a opens (304). Next, the judgment unit 103 acquires the maximum pressure measurement value Pb in the cycle in which the water supply two-way solenoid valve 114b opens (i.e., the i+1th cycle) (305). Next, the judgment unit 103 acquires the maximum pressure measurement value Pc in the cycle in which the water supply two-way solenoid valve 114c opens (i.e., the i+2th cycle) (306). Next, the judgment unit 103 acquires the maximum pressure measurement value Pd in ​​the cycle in which the water supply two-way solenoid valve 114d opens (i.e., the i+3th cycle) (307).

[0143] The determination unit 103 compares Pa, Pb, Pc, and Pd (308) and determines whether or not there is an abnormality (309).

[0144] If Pa, Pb, Pc, and Pd are all the same or nearly the same value, the determination unit 103 determines that "the liquid supply unit is normal" (311). More specifically, it may determine that there is no abnormality in the water discharge flow path. On the other hand, if any of Pa, Pb, Pc, and Pd is a different value or substantially different value from the others, it determines that "the liquid supply unit is abnormal" (310). More specifically, it may determine that there is no abnormality in the water discharge flow path.

[0145] A specific judgment criterion can be appropriately designed by a person skilled in the art. For example, the maximum and minimum values ​​of Pa, Pb, Pc, and Pd may be specified, and if the difference between them is equal to or less than a predetermined threshold, it may be judged that there is no abnormality, and if not, it may be judged that there is an abnormality.

[0146] When an abnormality in liquid supply unit 123 is detected (310), determination unit 103 outputs information indicating that there is an abnormality in the liquid supply unit. For example, determination unit 103 outputs information indicating that an abnormality may have occurred due to poor opening and closing of water supply two-way solenoid valves 114a-114d, a reduction in the inner diameter of the piping in liquid supply unit 123, or a break in the piping in liquid supply unit 123. The manner of output can be designed arbitrarily, and is realized, for example, by display on a display device and / or storage in a storage medium. By outputting the information, a user of the automatic analyzer can be made aware of the possibility of an abnormality occurring.

[0147] For example, when the judgment unit 103 detects an abnormality in the liquid supply unit 123, it may output information indicating that there is a possibility that an abnormality has occurred in which liquid is not being supplied in the path associated with the water supply two-way solenoid valve 114a-114d having the largest maximum pressure.

[0148] In this way, the automatic analyzer sequentially operates the water supply two-way solenoid valves 114a-114d to supply liquid, and detects an abnormality in the liquid supply unit 123 based on the fluctuation in the pressure measurement value of the reaction vessel side vacuum tank 88 when the liquid is aspirated. In this way, an abnormality in the liquid supply system can be detected.

[0149] In this embodiment, the determination unit 103 detects an abnormality in the automatic analyzer (for example, liquid supply unit 123) based on the pressure measurement values ​​Pa, Pb, Pc, and Pd in ​​each cycle. That is, an abnormality is determined based on the pressure value of the same pump on the same day. In this way, by detecting an abnormality based on the pressure measurement values ​​of consecutive cycles, it is possible to eliminate day-to-day differences and individual differences in the pump, and abnormality detection can be performed without reducing accuracy.

[0150] It is also possible to use a barometer, a thermometer, etc. to measure factors that affect the performance of the vacuum pump, such as air pressure and temperature, and eliminate the day-to-day difference of the vacuum pump from the measured values. Also, the individual difference of the vacuum pump may be determined in advance and eliminated.

[0151] In this embodiment, abnormalities are detected from the pressure measurement value (for example, the maximum value) at a specific time during each cycle. In other words, abnormalities can be detected by obtaining pressure measurement data at least at one time per cycle. Therefore, abnormalities can be detected with a small amount of data.

[0152] Moreover, the pressure can be measured only by the reaction vessel side pressure sensor 72. In other words, there is no need to install a pressure sensor for each system, which allows the device to be made smaller and less expensive.

[0153] In this embodiment, the determination unit 103 detects an abnormality in the automatic analyzer by comparing the pressure measurement values ​​at the time when the pressure in the reaction vessel side vacuum tank 88 is at its maximum. As a modified example, the determination unit 103 may detect an abnormality in the automatic analyzer by comparing the pressure measurement values ​​at the time when the pressure in the reaction vessel side vacuum tank 88 is at its minimum. When the maximum or minimum value is used, the detection accuracy is not affected even if a slight time lag occurs in the cycle.

[0154] In another modified example, the determination unit 103 may detect an abnormality in the automatic analyzer by comparing pressure measurement values ​​at a predetermined time during the operation cycle of the water supply two-way solenoid valves 114a to 114d. For example, as in the modified example of the first embodiment, the pressure measurement value at time t (FIG. 5A) during each cycle may be used. Using the measurement value at the predetermined time makes it possible to detect an abnormality when a time lag occurs in the cycle.

[0155] In this embodiment, the process ends after step 310 or 311, but as a variant, the process may return to step 304 after step 310 or 311. In this way, the determination is made continuously in each cycle.

[0156] The present invention is not limited to the above-mentioned embodiment, but includes various modifications. For example, the above-mentioned embodiment has been described in detail to clearly explain the present invention, and is not necessarily limited to those including all of the configurations described. It is also possible to add a part of the configuration of one embodiment to the configuration of another embodiment. It is also possible to add, delete, or replace a part of the configuration of each embodiment with another configuration. [Explanation of symbols]

[0157] 2 (2a to 2d)…Reaction vessel 21...Controller (control unit) 31…A side reagent probe cleaning tank (cleaning tank) 32…B side reagent probe cleaning tank (cleaning tank) 35…A system (suction system) 36...B system (suction system) 41... Reagent probe washing tank side suction unit (first suction unit) 42...Reaction vessel side suction unit (second suction unit) 53...Reaction vessel side vacuum pump (second vacuum pump) 54... Vacuum pump for reagent probe washing tank (first vacuum pump) 71...Reagent probe washing tank side pressure sensor (first pressure sensor) 72...Reaction vessel side pressure sensor (second pressure sensor) 80...A side waste liquid bottle (first vacuum bottle) 81...B side waste liquid bottle (first vacuum bottle) 83...Reaction vessel side waste liquid bottle (second vacuum bottle) 87... Vacuum tank for reagent probe washing tank (first vacuum tank) 88…Reaction vessel side vacuum tank (second vacuum tank) 101...A side two-way solenoid valve (first suction solenoid valve) 102...B side two-way solenoid valve (first suction solenoid valve) 103...Judgment section 111…Water tank 112…Water supply pump 113…Gear pump 121...Reaction vessel side three-way solenoid valve (second suction solenoid valve) 123...Liquid supply unit 114 (114a to 114f)...Water supply two-way solenoid valve (water supply solenoid valve) Pa~Pd…Pressure measurement value TH1: Threshold (first threshold) TH2: Threshold (second threshold)

Claims

1. A first vacuum pump; a first vacuum tank connected to the first vacuum pump; A first pressure sensor installed in the first vacuum tank; a first vacuum bottle connected to the first vacuum tank; A plurality of first suction solenoid valves; A control unit; A determination unit; An automatic analyzer comprising: The first vacuum tank sucks liquid from a plurality of reaction vessels or cleaning tanks each containing a liquid, each of the plurality of first suction solenoid valves is installed between the first vacuum tank and the first vacuum bottle, and adjusts a suction pressure by opening and closing when the first vacuum tank sucks liquid; The control unit controls opening and closing of each of the first suction solenoid valves, The automated analyzer has a plurality of independent aspiration systems, Each of the suction systems has the first suction solenoid valve, and the suction state of each of the suction systems is controlled individually. the determination unit detects an abnormality in the automated analyzer by comparing the pressure measurement values ​​during suction related to each of the suction systems based on the pressure measurement value of the first vacuum tank measured by the first pressure sensor. An automatic analyzer characterized by:

2. 2. The automated analyzer according to claim 1, An automatic analyzer according to claim 1, wherein a difference in a fluctuation range of the pressure measurement value due to operation of the first suction solenoid valve in each of the suction systems is equal to or smaller than a first threshold value under normal conditions.

3. 2. The automated analyzer according to claim 1, The automatic analyzer according to claim 1, wherein the determination unit detects an abnormality based on the pressure measurement value during an analysis operation by the automatic analyzer.

4. 2. The automated analyzer according to claim 1, The automated analyzer comprises: A second vacuum pump; a second vacuum tank connected to the second vacuum pump; A second pressure sensor installed in the second vacuum tank; a second vacuum bottle connected to the second vacuum tank; A second suction solenoid valve; Equipped with The automatic analyzer according to claim 1, wherein the determination unit detects an abnormality in the automatic analyzer individually in relation to the first vacuum tank and the second vacuum tank.

5. 2. The automated analyzer according to claim 1, the determination unit detects an abnormality in the automatic analyzer by comparing the pressure measurement values ​​at the time when the pressure in the first vacuum tank is at its maximum or its minimum.

6. 2. The automated analyzer according to claim 1, The automatic analyzer according to claim 1, wherein the determination unit detects an abnormality in the automatic analyzer by comparing the pressure measurement values ​​at predetermined times during an operation cycle of the first suction solenoid valve.

7. 2. The automated analyzer according to claim 1, The automatic analyzer is characterized in that when the judgment unit detects an abnormality in the automatic analyzer, it outputs information indicating that an abnormality may have occurred due to failure to open or close the first suction solenoid valve, a reduction in the inner diameter of the piping, or a break in the piping.

8. 2. The automated analyzer according to claim 1, The automated analyzer includes a liquid supply unit and a plurality of water supply solenoid valves; The liquid supply unit includes: a water pump for supplying the liquid; a water supply tank for supplying liquid to the water supply pump; a gear pump for applying pressure to the liquid; Equipped with the plurality of water supply solenoid valves are respectively installed between the gear pump and the reaction vessel or the cleaning tank, and adjust the supply pressure by opening and closing when the liquid supply unit supplies liquid; The automatic analyzer according to claim 1, wherein the determination unit detects an abnormality in the liquid supply unit based on the pressure measurement value.

9. 9. The automated analyzer according to claim 8, The automatic analyzer is characterized in that it supplies liquid by sequentially operating the multiple water supply solenoid valves, and detects an abnormality in the liquid supply unit based on fluctuations in the pressure measurement values ​​when the liquid is aspirated.

10. 2. The automated analyzer according to claim 1, The automatic analyzer is characterized in that, when the determination unit detects an abnormality in the automatic analyzer, it outputs information indicating that an abnormality may have occurred in any of the suction systems.

11. 2. The automated analyzer according to claim 1, The automatic analyzer is characterized in that the judgment unit judges that an abnormality in the automatic analyzer has been detected when a difference in the fluctuation range of the pressure measurement value due to the operation of the first suction solenoid valve in each of the suction systems exceeds a second threshold value.

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