Hydrogenation of esters to alcohols in the presence of Ru-PNN complexes

Abstract

The present invention relates to a method for hydrogenating an ester to the corresponding alcohol with molecular hydrogen in the presence of a ruthenium complex (I), wherein the complex comprises a tridentate ligand L of general formula (II), wherein n and m are each independently 0 or 1, and the solid-dashed double lines represent a single bond or a double bond, provided that when n=1, both solid-dashed double lines represent single bonds and m is 1, and when n=0, one solid-dashed double line represents a single bond and the other solid-dashed double line represents a double bond, and when the double bond is on the side facing the phenyl ring, m=1, and when the double bond is on the side facing the pyridyl ring, m=0, or both solid-dashed double lines represent single bonds and m is 1. [Formula 1] TIFF2022538350000056.tif29142

Description

[Technical Field]

[0001] The present invention relates to a method for hydrogenating an ester with molecular hydrogen in the presence of a ruthenium complex having a tridentate PNN ligand to give the corresponding alcohol. [Background technology]

[0002] Alcohols are not only important solvents, but also important intermediates and synthetic units for producing, for example, pharmaceuticals, plant protection agents or fragrances. Depending on the type of desired alcohol and the availability of the corresponding starting material, direct hydrogenation of the corresponding ester with hydrogen or reduction with a reducing agent is often the method of choice.

[0003] The synthesis of alcohols from esters is usually achieved by heterogeneous catalytic hydrogenation with hydrogen through the use of metal hydrides, such as LiAlH or NaBH, or by homogeneous catalytic hydrogenation with hydrogen. Homogeneous catalytic hydrogenation with hydrogen often results in less drastic reaction conditions and at the same time excellent selectivity. The prior art has demonstrated that this is particularly achieved by the use of ruthenium complexes with multidentate phosphorus-, sulfur-, and nitrogen-containing ligands.

[0004] For example, U.S. Patent No. 8,013,193 describes the use of Ru complexes with triphos ligands, such as 1,1,1-tris(diphenylphosphinomethyl)ethane, in the hydrogenation of lactones and esters. However, the mentioned complexes exhibit much lower reaction rates. Acceptable reaction rates can only be achieved by using a very specific activating solvent (2,2,2-trifluoroethanol). However, the added solvent must then be separated from the product again.

[0005] Another disadvantage of the triphos ligand is the high phosphorus / ruthenium molar ratio of 3. Phosphine ligands are complex to prepare. Furthermore, the three phosphino groups result in a relatively high molar mass of the complexing ligand and the Ru complex to be used. This high molar mass is fundamentally disadvantageous from the standpoint of general handling. Subsequent disposal of the used Ru complex is expensive, since more mass must be discarded and the phosphorus-containing component requires special disposal.

[0006] A series of different publications have described Ru complexes with tetradentate PNNP ligands for the hydrogenation of esters to alcohols. For example, Saudan et al., in Angewandte Chemie International Edition 2007, Vol. 46, pp. 7473-7476, U.S. Pat. Nos. 7,989,665, 8,124,816, 8,524,953 and 9,193,651, inter alia:

[0007] [ka] (where the dashed line represents an optional double bond in each case) disclose the use of ligands of the type [Formula 1]. Additional ligands in hexacoordinated Ru complexes are, inter alia, Cl, H, BH4, CO, OH, alkoxy, carboxy, and monophosphines. Based on a series of tests on Ru complexes with bidentate and tetradentate P- and N-containing ligands, Saudan et al. point out in the aforementioned article that two amino-phosphino bridging ligands are required in the Ru complexes for hydrogenating esters to alcohols. These may be in the form of a PNNP ligand or two PN ligands in the Ru complexes.

[0008] The disadvantage of using Ru complexes with one PNNP ligand or two PN ligands is the high phosphorus / ruthenium molar ratio of 2. As already mentioned above, phosphine ligands are complex to prepare. Furthermore, they lead to a relatively high molar mass of the Ru complex, which is disadvantageous due to its low atom economy (larger mass per catalyst complex) compared to smaller catalyst complexes with the same catalytic activity.

[0009] The drawback of high phosphorus content is that tridentate PNP ligands of the general structure described in U.S. Pat. No. 8,471,048

[0010] [ka] where the Ru-catalyzed hydrogenation of esters and ketones and lactones to alcohols has also been previously described.

[0011] A drawback of this ligand is its complicated synthesis via bis(2-chloroethyl)ammonium chloride and its reaction with diphenylphosphine and potassium tert-butoxide, followed by workup with HCl (see Whitesides et al., J. Org. Chem. 1981, 46, 2861-2867).

[0012] Milstein et al., in Angewandte Chemie International Edition 2006, Vol. 45, pp. 1113-1115, describe the use of Ru complexes with so-called pincer ligands of the PNN type for the hydrogenation of esters to alcohols. The tridentate pincer ligands described have a pyridyl group as the backbone and phosphino and amino groups, each with a low-molecular-weight alkyl group as the donor group. The name mentioned here is the use of (2-(di-tert-butylphosphinomethyl)-6-(diethylaminomethyl)pyridine.

[0013] [ka]

[0014] Similar pincer ligands of the PNN type for the hydrogenation of esters to alcohols are also described in US Pat. No. 8,178,723 and US Pat. No. 2017 / 0,283,447.

[0015] The drawback of using the mentioned PNN type pincer ligands is that they require starting from 2,6-dimethylpyridine, reacting it with N-bromosuccinimide and diethylamine to give 2-diethylaminomethyl-6-methylpyridine, then activating its methyl group by reaction with butyllithium and reacting it with di-tert-butylphosphine to give P t Its complex, multi-step synthesis using modern reagents ultimately leads to the addition of the Bu2 group.

[0016] US Patent No. 2014 / 0,328,748 teaches the Ru-catalyzed hydrogenation of esters and lactones to alcohols, catalyzed by Ru complexes having PNN ligands characterized by a nitrogen-containing heterocycle, an aliphatic bridge to the amine nitrogen, and a further aliphatic bridge having a length of at least two carbons from this to a phosphino group. Typical representatives of this category include compounds of the structure

[0017] [ka] where R is an alkyl group, such as isopropyl or tert-butyl, or a phenyl group.

[0018] This ligand is also accessible only through a complex synthesis involving the -NH-CHCH-PR unit. For example, the synthetic unit HN-CHCH-PR is usually produced by reacting HPR with the difficult-to-obtain 2-chloroethylamine and HCl. Furthermore, phosphines with the structural unit -CHCH-PR (where R = iPr) are relatively sensitive to oxidation, which has negative effects due to the poor storage stability of the ligand or the high handling costs caused by the use of protective gas atmospheres.

[0019] In Chemistry An Asian Journal 2016, Vol. 11, pp. 2103-2106, Zhang et al. disclose the use of Ru complexes bearing tetradentate bipyridine ligands as catalysts for the hydrogenation of esters to alcohols. In particular, they contain two PNNN ligands.

[0020] [ka] is being dealt with.

[0021] The authors teach that the bipyridine fragment is essential for high catalytic activity and is suitable for achieving high acidity of the NH group.

[0022] These ligands also have significant drawbacks. For example, their synthesis from common synthetic units is complicated due to the bipyridine fragment. Starting from 2-bromopyridine and 2-(diphenylphosphaneyl)ethylamine or (2-(diphenylphosphaneyl)phenyl)methylamine, each requires a four-step synthesis using n-butyllithium. The ligands shown above containing the -CH2C6H4-PPh2 unit also have relatively high molar masses. The negative effects of a high molar mass have already been mentioned above. Furthermore, a catalytic investigation in the cited references shows that ligands containing the -CH2C6H4-PPh2 unit allow yields of more than 60% only in toluene as solvent and in the presence of sodium alkoxide as base.

[0023] In Organometallics 2007, Vol. 26, pp. 5636-5642, Rigo et al., the structure of the transfer hydrogenation of ketones with 2-propanol to the corresponding secondary alcohols and acetone is described.

[0024] [ka] The use of the tridentate PNN ligand of the formula (I) after its reaction with RuCl2(PPh3)3 to form the corresponding Ru complex is taught. Thus, in transfer hydrogenation, the reducing agent is not hydrogen, but a reducing compound, such as a secondary alcohol or HCOOH / amine, is used. However, it is known that catalysts well suited for the transfer hydrogenation of ketones to alcohols usually do not exhibit sufficient activity in the hydrogenation of esters to alcohols. Transfer hydrogenation catalysts for ketones differ from hydrogenation catalysts for esters both structurally and in terms of their reactivity.

[0025] For example, in the Journal of the American Chemical Society (1996), Vol. 118, pp. 2521-2522, it was shown that Ru complexes, particularly (R)-RuCl[(1S,2S)-p-TsNCH(CH)CH-(CH)NH](η-mesitylene), which are highly suitable for the transfer hydrogenation of ketones to alcohols, easily achieve 99% yields in the transfer hydrogenation of ketones, but only 5% yields in hydrogenation using hydrogen. Furthermore, Noyori et al. showed that in the case of a substrate having an ester functional group in addition to a keto functional group, only the keto functional group is reduced to the corresponding alcohol in the transfer hydrogenation, but the ester functional group is not reduced.

[0026] WO 2017 / 134,618 discloses the use of ruthenium and osmium monocarbonyl complexes in the transfer hydrogenation of ketones and aldehydes and the hydrogenation of ketones and aldehydes with hydrogen to give the corresponding alcohols, the monocarbonyl complexes also containing nitrogen- and phosphorus-containing ligands. Among the many nitrogen- and phosphorus-containing ligands mentioned, also disclosed are, inter alia, the compounds of the structure

[0027] [ka] is a tridentate PNN ligand.

[0028] WO 2017 / 134,618 confirms in numerous examples that Ru complex catalysts that achieve high yields in the transfer hydrogenation of ketones have significantly lower conversion rates in hydrogenation. For example, in the transfer hydrogenation of acetophenone with 2-propanol to give 1-phenylethanol, Ru complex catalysts with numbers 16, 20, and 22 each show 100% conversion, but in the hydrogenation of acetophenone with hydrogen, the same Ru complex catalysts only achieve 25 to 63% conversion. The Ru complex catalyst with the aforementioned PNN ligand ([Ru(OAc)2(CO)(PNN)]) achieves only 96% conversion in the transfer hydrogenation of acetophenone with 2-propanol to give 1-phenylethanol, and has not been tested in the hydrogenation of acetophenone with hydrogen.

[0029] In summary, it can be stated that the ligands described in the prior art for the homogeneously catalyzed hydrogenation of esters to alcohols have relatively high molar masses, and / or are relatively complex and laborious to prepare, and / or have only relatively low chemical stability. Furthermore, it is generally known that ligands that give very good results in the transfer hydrogenation of ketones to alcohols are usually not very suitable as reducing agents in hydrogenation with hydrogen, and in particular are often unsuitable in the hydrogenation of esters. Summary of the Invention [Problem to be solved by the invention]

[0030] The object of the present invention was to find a process for the homogeneously catalyzed hydrogenation of esters to the corresponding alcohols which is free of or only to a limited extent from the disadvantages described in the prior art, is easy to carry out in terms of the required equipment and reaction conditions, and allows the highest possible space-time yield.

[0031] In particular, catalytically active complexes should be directly prepared from readily available raw materials, have high activity in the hydrogenation of esters to alcohols, and ultimately be disposable without excessive cost. In this context, complexing ligands are particularly important. In order to manage as little catalyst mass as possible, preferred ligands should have the lowest possible molar mass with comparable catalytic activity and comparable preparation costs. Furthermore, it is desirable for the ligands to have high chemical stability so that they exhibit storage stability before use and remain stable during use without requiring particularly complicated measures.

[0032] Furthermore, the catalytically active complexes can be used to hydrogenate a large number of esters, regardless of their molar mass and further structure. [Means for solving the problem]

[0033] Surprisingly, a method for hydrogenating an ester with molecular hydrogen in the presence of a penta- or hexacoordinated ruthenium complex (I) at a temperature of 50 to 200°C and a pressure of 0.1 to 20 MPa abs to give the corresponding alcohol, wherein the ruthenium complex is optionally bridged to form a dimer, and the ruthenium complex is a tridentate ligand L of the general formula (II)

[0034] [ka] (In the formula, R 1 , R2 are each independently an aliphatic hydrocarbon group having 1 to 8 carbon atoms, an aromatic hydrocarbon group having 6 or 10 carbon atoms, or an araliphatic hydrocarbon group having 7 to 12 carbon atoms, the specified hydrocarbon group being unsubstituted or substituted with 1 to 3 methoxy, thiomethoxy, or dimethylamino groups; and two groups R 1 and R 2 may be bonded to each other to form a 5- to 10-membered ring containing a phosphorus atom, R 3 , R 4 , R 5 , R 6 , R 10 , R 11 are each independently hydrogen, linear C1 to C4 alkyl, branched C3 to C4 alkyl, methoxy, hydroxyl, trifluoromethyl, nitrile, or dialkylamino, each independently having from 1 to 4 carbon atoms per alkyl group; R 7 , R 8 , R 9 are each independently hydrogen, linear C1 to C4-alkyl or branched C3 to C4-alkyl, n and m each independently represent 0 or 1; A solid-dashed double line represents a single or double bond, provided that: When n=1, both solid-dashed double lines represent single bonds, and m is 1; When n=0, one solid-dashed double line represents a single bond, the other solid-dashed double line represents a double bond, and when the double bond is on the side facing the phenyl ring, m=1, and when the double bond is on the side facing the pyridyl ring, m=0, or both solid-dashed double lines represent single bonds and m is 1. A method has been found which includes: DETAILED DESCRIPTION OF THE INVENTION

[0035] The core of the process according to the invention is the use of a penta- or hexacoordinate ruthenium complex (I) containing a tridentate ligand L of general formula (II) in the hydrogenation of esters with molecular hydrogen to give the corresponding alcohols.

[0036] The tridentate ligand L is a so-called PNN ligand of general formula (II)

[0037] [ka] (In the formula, R 1 , R 2 are each independently an aliphatic hydrocarbon group having 1 to 8 carbon atoms, an aromatic hydrocarbon group having 6 or 10 carbon atoms, or an araliphatic hydrocarbon group having 7 to 12 carbon atoms, the specified hydrocarbon group being unsubstituted or substituted with 1 to 3 methoxy, thiomethoxy, or dimethylamino groups; and two groups R 1 and R 2 may be bonded to each other to form a 5- to 10-membered ring containing a phosphorus atom, R 3 , R 4 , R 5 , R 6 , R 10 , R 11 are each independently hydrogen, linear C1 to C4 alkyl, branched C3 to C4 alkyl, methoxy, hydroxyl, trifluoromethyl, nitrile, or dialkylamino, each independently having from 1 to 4 carbon atoms per alkyl group; R 7 , R 8 , R 9 are each independently hydrogen, linear C1 to C4-alkyl or branched C3 to C4-alkyl, n and m each independently represent 0 or 1; A solid-dashed double line represents a single or double bond, provided that: When n=1, both solid-dashed double lines represent single bonds, and m is 1; When n=0, one solid-dashed double line represents a single bond, the other solid-dashed double line represents a double bond, and if the double bond is on the side facing the phenyl ring, then m=1; if the double bond is on the side facing the pyridyl ring, then m=0; or both solid-dashed double lines represent single bonds and m=1).

[0038] Tridentate means that the ligand L(II) occupies three coordination sites in the ruthenium complex (I). The three ligand donor atoms are P and two N atoms, hence the name PNN ligand.

[0039] With regard to the environment of the central donor atom, the ligand can in principle have four different substructures, which are described in more detail below.

[0040] (1) When n=1, both solid-dashed double lines represent single bonds and m is 1. This gives general formula (IIa). Ligand (IIa) is neutral, and therefore has a charge of "0".

[0041] [ka]

[0042] When n=0, there are a total of three different substructures.

[0043] (2) When n=0, the solid-dashed double line facing the phenyl ring is a double bond, and the solid-dashed double line facing the pyridyl ring is a single bond, m is equal to 1. This gives the general formula (IIb). The ligand (IIb) is neutral and therefore has a charge of "0".

[0044] [ka]

[0045] (3) When n=0, the solid-dashed double line facing the pyridyl ring is a double bond, and the solid-dashed double line facing the phenyl ring is a single bond, m is equal to 0. This gives the general formula (IIc). The ligand (IIc) is neutral, and therefore has a charge of "0".

[0046] [ka]

[0047] (4) In the fourth variant, n=0, but both solid-dashed double lines are single bonds, and m=1. As a result, the N atom has a negative charge. This gives the general formula (IId). The ligand (IId) therefore has a charge of "-1".

[0048] [ka]

[0049] R of ligand (II) 1 and R 2 The groups may vary widely and are each independently an aliphatic hydrocarbon group having 1 to 8 carbon atoms, an aromatic hydrocarbon group having 6 or 10 carbon atoms, or an araliphatic hydrocarbon group having 7 to 12 carbon atoms, where the designated hydrocarbon group may be unsubstituted or substituted with 1 to 3 methoxy, thiomethoxy, or dimethylamino groups, and the two groups R 1 and R 2 may be bonded to each other to form a 5- to 10-membered ring containing the phosphorus atom.

[0050] In the case of an aliphatic hydrocarbon group, it may be unbranched or branched, linear or cyclic. The aliphatic hydrocarbon group preferably has 1 to 6 carbon atoms, particularly preferably 1 to 4 carbon atoms, and particularly preferably 1 to 2 carbon atoms. Specific examples that may be mentioned are methyl, ethyl, isopropyl, n-propyl, n-butyl, isobutyl, tert-butyl (also called tBu) and cyclohexyl (also called Cy).

[0051] In the case of one aromatic hydrocarbon group, this is phenyl (also called Ph), 1-naphthyl or 2-naphthyl.

[0052] The araliphatic hydrocarbon group comprises aromatic and aliphatic elements, whether bonded to the phosphorus atom in the ligand L via an aliphatic or aromatic group. The araliphatic hydrocarbon group preferably has 7 to 10 carbon atoms, particularly preferably 7 to 9 carbon atoms. Specific examples which may be mentioned are o-tolyl, m-tolyl, p-tolyl and benzyl.

[0053] In the case of one ring containing a phosphorus atom, it is preferably a ring having 5 to 6 atoms including the phosphorus atom. Examples which may be mentioned are butane-1,4-diyl, pentane-1,5-diyl and 2,4-dimethylpentane-1,5-diyl.

[0054] The aliphatic, aromatic and araliphatic hydrocarbon groups mentioned may be bonded to each other to form a ring containing the phosphorus atom and may be unsubstituted or substituted with 1 to 3 methoxy, thiomethoxy or dimethylamino groups. The number of carbon atoms in each hydrocarbon group specified above should be understood to include the carbon atoms of the methoxy, thiomethoxy or dimethylamino groups. Specific examples that may be mentioned are 3,5-dimethylphenyl, 3,5-dimethyl-4-methoxyphenyl, 3,5-dimethyl-4-thiomethoxyphenyl and 3,5-dimethyl-4-(dimethylamino)phenyl.

[0055] R 1 and R2 The radicals are particularly preferably phenyl, p-tolyl, o-tolyl, 4-methoxyphenyl, 2-methoxyphenyl, cyclohexyl, isobutyl, tert-butyl, 3,5-dimethyl-4-methoxyphenyl, 3,5-tert-butyl-4-methoxyphenyl and 3,5-dimethylphenyl, particularly preferably phenyl, p-tolyl, 3,5-dimethyl-4-methoxyphenyl, isobutyl and cyclohexyl, preferably both radicals being the same.

[0056] R 3 , R 4 , R 5 , R 6 , R 10 and R 11 The groups are each independently hydrogen, linear C1 to C4 alkyl, branched C3 to C4 alkyl, methoxy, hydroxyl, trifluoromethyl, nitrile, or dialkylamino, each independently having 1 to 4 carbon atoms per alkyl group. What is referred to as linear C1 to C4 alkyl is methyl, ethyl, n-propyl, and n-butyl, and what is referred to as branched C3 to C4 alkyl is isopropyl, sec-butyl, and tert-butyl. As dialkylamino, particular mention should be made of amino groups having the same alkyl groups, in particular dimethylamino, diethylamino, di-n-propylamino, and di-n-butylamino.

[0057] R 3 and R 4 The radicals are preferably each independently hydrogen or methyl, particularly preferably hydrogen.

[0058] R 5 The radicals are preferably hydrogen, methyl, isopropyl, sec-butyl, tert-butyl, methoxy, hydroxyl or dialkylamino, particularly preferably hydrogen, methyl or hydroxyl and especially preferably hydrogen.

[0059] R 6 The group is preferably hydrogen.

[0060] R 10 The radicals are preferably hydrogen, methyl, isopropyl, sec-butyl, tert-butyl or methoxy, particularly preferably hydrogen, methyl or tert-butyl, particularly preferably hydrogen.

[0061] R 11 The radicals are preferably hydrogen, methyl, ethyl, methoxy, ethoxy or isopropyloxy, particularly preferably hydrogen, methyl or methoxy.

[0062] Particularly preferred are: -R 3 , R 4 , R 5 , R 6 , R 10 and R 11 is hydrogen, -R 3 , R 4 , R 5 , R 6 and R 10 is hydrogen and R 11 is methyl, -R 3 , R 4 , R 5 , R 6 and R 10 is hydrogen and R 11 is methoxy, -R 3 , R 4 , R 6 , R 10 and R 11 is hydrogen and R 5 is methyl, -R 3 , R 4 , R 6 , R 10 and R 11 is hydrogen and R 5 is tert-butyl, -R 3 , R 4 , R 5 , R 6 and R 11 is hydrogen and R 10 is methyl, -R 3 , R 4 , R 5 , R 6 and R 11 is hydrogen and R 10 is tert-butyl, -R 3 , R 4 , R 5 and R 6 is hydrogen and R 10 and R 11 is methyl, ligand (II).

[0063] R 7 , R 8 and R 9 The groups are each independently hydrogen, linear C1 to C4-alkyl or branched C3 to C4-alkyl. What will be referred to as linear C1 to C4-alkyl is methyl, ethyl, n-propyl and n-butyl, and what will be referred to as branched C3 to C4-alkyl is isopropyl, sec-butyl and tert-butyl.

[0064] R 7 , R 8 and R 9 The radicals are preferably each independently hydrogen, methyl, ethyl or n-propyl, particularly preferably hydrogen or methyl, particularly preferably hydrogen.

[0065] Particularly preferred are: -R 7 , R 8 and R 9 is hydrogen, -R 7 and R 9 is hydrogen and R 8 is methyl, -R 7 is hydrogen and R 8 and R 9 is methyl, -R 7 is methyl and R 8 and R 9 is hydrogen, -R 7 and R 8 is methyl and R 9 is hydrogen, ligand (II).

[0066] Particularly advantageous in the method according to the invention are (i) n and m are 1 in each case and the two solid-dashed double lines represent a single bond (structure (IIa)), or (ii) n is 0, m is 1, the solid-dashed double line facing the phenyl ring represents a double bond, and the solid-dashed double line facing the pyridyl ring represents a single bond (structure (IIb), -R 1 and R 2 are both phenyl, p-tolyl, 3,5-dimethyl-4-methoxyphenyl, isobutyl, or cyclohexyl; -R 3 , R 4 and R 6 The group is hydrogen, -R 5 and R 10 The group is hydrogen, methyl, or tert-butyl; -R 11 The group is hydrogen, methyl or methoxy, -R 7 , R 8 and R 9 The use of ligand (II) in which the group is hydrogen or methyl.

[0067] Ligands (II) can be obtained in a simple manner by condensation of the corresponding amine with the corresponding aldehyde or ketone (ligands (IIb) and (IIc)), possibly followed by reduction (ligand (IIa)), and possibly followed by deprotonation under basic conditions (ligand (IId)).

[0068] In principle, two different possibilities exist for the condensation: First, it is possible to use 2-picolylamine or its corresponding derivative as the amine component and an appropriately substituted phosphanylbenzaldehyde or the corresponding ketone as the aldehyde or ketone component.

[0069] [ka]

[0070] Secondly, however, it is also possible to use appropriately substituted phosphanylphenylmethanamines as the amine component and picolinaldehyde or its corresponding derivatives as the aldehyde or ketone component.

[0071] [ka]

[0072] The corresponding starting compounds (amines, ketones, or aldehydes) are generally commercially available or can be synthesized using commonly known methods. The synthesis of ligands (IIb) and (IIc) is usually carried out under a protective gas atmosphere. The two components are typically reacted with each other in a solvent at temperatures of 50 to 200°C. Suitable solvents include, for example, aliphatic alcohols such as methanol, ethanol, or isopropanol, and aromatic hydrocarbons such as toluene or xylene. The two starting compounds may be used in stoichiometric amounts. However, it is also possible to use an excess of one of the two components, for example, to increase the conversion of the other component. This is particularly useful when access to the other component is difficult. When an excess is used, the molar ratio of the two starting compounds is generally in the range of more than 1 to 2 or less. The reaction time typically ranges from several minutes to several hours. Typical reaction times that may be mentioned are 10 minutes to 5 hours, preferably 30 minutes to 3 hours. The reaction mixture may be worked up, and the ligand is isolated by conventional methods. However, added solvents and water are advantageously removed under reduced pressure.

[0073] Ligands (IIb) and (IIc) can be used to prepare ruthenium complexes (I).

[0074] A particularly elegant and therefore preferred variant combines the synthesis of ligands (IIb) and (IIc) with the preparation of ruthenium complex (I) in a single reaction. For this purpose, the starting compounds (amine and ketone or aldehyde) are first reacted with each other as described above, but without subsequent workup and isolation, the corresponding ruthenium precursor, optionally a base for forming catalytically active ruthenium complex (I), is added to the resulting reaction mixture. By adjusting the hydrogenation conditions and adding an ester to be hydrogenated, it is therefore very easy to prepare ligand (II) in a single reaction, then directly prepare ruthenium complex (I) from it, and then directly hydrogenate the ester.

[0075] Ligand (IIa) can be obtained in a simple manner from ligands (IIb) and (IIc) by reducing ligand (IIb) or (IIc) with a reducing agent such as sodium borohydride or lithium aluminum hydride, or by catalytic reduction with hydrogen. The reaction can be carried out using the general knowledge of a person skilled in the art.

[0076] In a particularly advantageous synthesis, the above-mentioned condensation and reduction to ligand (IIa) are carried out directly one after the other in a one-pot reaction without prior isolation of ligands (IIb) and (IIc). To achieve this, after the condensation is complete, a reducing agent is added directly to the reaction mixture and they are allowed to react with each other for a further period of time. Again, a period of several minutes to several hours is usually sufficient. Typical reaction times that can be mentioned are 10 minutes to 5 hours, preferably 30 minutes to 3 hours. The reaction mixture can then be worked up, and the ligand is isolated by conventional methods. Information available regarding the workup and isolation of ligands (IIb) and (IIc) is explicitly mentioned.

[0077] Ligand (IIa) is formed from ligands (IIb) and (IIc) and is again bound in the ruthenium complex (I) by hydrogenation with hydrogen supplied under the reaction conditions.

[0078] Anionic ligand (IId) is formed from ligand (IIa) by reaction with a strong base, resulting in the elimination of the hydrogen atom on nitrogen as a proton. Suitable strong bases are, for example, NaOMe or KOMe. Usually, this reaction is not carried out using free ligand (IIa). Rather, ligand (IId) can be formed in ruthenium complex (I) under hydrogenation conditions in the presence of a strong base.

[0079] The ruthenium complex (I) to be used in the method according to the present invention is penta- or hexa-coordinated. Three of these coordination positions are already occupied by the tridentate ligand (II). The ruthenium complex (I) may be mononuclear or binuclear, i.e., bridged as a dimer. When the ruthenium complex (I) is bridged to form a dimer, it has two ruthenium atoms in the complex.

[0080] In the method according to the present invention, the oxidation state of ruthenium in the ruthenium complex (I) is not limited, but is usually 0 (zero), +2 or +3, preferably +2 or +3.

[0081] The ruthenium complexes (I) preferably used in the process according to the invention contain ruthenium in the oxidation state +2 or +3 and have the general formula (IA) [Ru(L)X a Y b ] p Z (p·c) (IA) (In the formula, X is independently in each occurrence a neutral monodentate ligand, and two ligands X may be combined to form a neutral bidentate ligand; Y in each occurrence is independently an anionic monodentate ligand having a charge of "-1"; Y and X may together be an anionic bidentate ligand having a charge of "-1"; Z is independently in each occurrence a non-coordinating anion having a charge of "-1", and two ligands Z may combine to form a non-coordinating anion having a charge of "-2", a, b, and c are each independently 0, 1, 2, or 3; p is 1 or 2; however, a+b+c is equal to 1, 2, 3, 4, 5 or 6, b and c are determined so that the ruthenium complex (IA) has a total charge of "0").

[0082] In the ruthenium complex (IA), the subscripts a, b, and c designate the number of ligands X, Y, and non-coordinating counterions Z, respectively, based on one ruthenium atom. Since the ligand (II) is tridentate and the ruthenium complex (IA) has a maximum of six coordinations, the maximum value of the subscripts is 3 in all cases.

[0083] The subscript p indicates whether the ruthenium complex (IA) is mononuclear (p=1) or dinuclear (p=2).

[0084] By observing further boundary conditions, the sum of a, b, and c can only assume values ​​of 1, 2, 3, 4, 5, and 6. Since the ruthenium complex (IA) is defined as totally neutral, any combination of a, b, and c is not possible.

[0085] For the sake of completeness, it should be explicitly pointed out that the subscript "(p·c)" in the general formula (IA) is the product "p × c".

[0086] In the process according to the invention, preferred ruthenium complexes (IA) are X in each case is independently CO, NH3, NR3, R2NS02R, PR3, AsR3, SbR3, P(OR)3, SR2, RCN, RNC, N2, NO, PF3, pyridine, thiophene, tetrahydrothiophene, and a group of the general formula

[0087] [ka] or two ligands X together are 1,5-cyclooctadiene, Independently, Y is H - , F - , Cl - , Br - , I - , O.H. - , C1 to C6-alkoxy, C1 to C6-carboxy, methylallyl, acetylacetonate, RSO3 - , CF3SO3 - , C.N. - and BH4 - or an anionic ligand selected from the group comprising: or one Y and one X together are C1 to C6-carboxy or acetylacetonato; Independently, Z is H - , F - , Cl - , Br - , I - , O.H. - , BF4 - , PF6 - , NO3 - , R.C.O.O. - , CF3COO - , CH3SO3 - , CF3SO3 - , BH4 - , NH2 - , R.O. - , C.N. - , R2N - , SCN - , OCN - , R.S. - , R-CONH - , (R-CO)N - , HCO3 - , HSO4 - , H2PO4 - , acetylacetonate, pentafluorobenzoate, bis(trimethylsilyl)amide, and tetrakis[3,5-bis(trifluoromethyl)phenyl]borate, or two ligands Z together form CO3 2- , SO42- , HPO4 2- , S 2- and The R groups in the definitions of X, Y, and Z are each independently C1 to C 10 -Alkyl, CF3, C2F5, C3 to C 10 -cycloalkyl, C3 to C containing at least one heteroatom selected from the group including N, O and S 10 -Heterocyclyl, C5 to C 10 -aryl or C5 to C containing at least one heteroatom selected from the group including N, O and S 10 -hetaryl ruthenium complexes.

[0088] The R groups are preferably each independently C1 to C4-alkyl, C5 to C6-cycloalkyl, o-tolyl, p-tolyl, xylyl or mesityl, particularly preferably methyl, xylyl or mesityl.

[0089] The neutral ligand X in the ruthenium complex (IA) is preferably CO, trimethylphosphine, triphenylphosphine, tricyclohexylphosphine, triphenylphosphine or trimethylphosphite, or two ligands X together form cycloocta-1,5-diene. The neutral ligand X is particularly preferably triphenylphosphine.

[0090] The anionic ligand Y in the ruthenium complex (IA) is preferably H - , Cl - , O.H. - , C1 to C4-alkoxy, C1 to C4-carboxy, methylallyl, acetylacetonate or bis(trimethylsilyl)amide, or the ligand Y and the ligand X together are C1 to C4-carboxy or acetylacetonate. The anionic ligand Y is particularly preferably H - , Cl - , methoxy or acetate.

[0091] Anionic ligands with an anionic O- group and a neutral O= group bonded to each other through an odd number of carbon atoms, such as carboxylates or acetylacetonates, can function as both monodentate and bidentate ligands, as demonstrated in the following example with the acetate anion.

[0092] [ka]

[0093] If the complex with the ligands L, X and Y is to have a positive charge, a corresponding number of non-coordinating anions Z are required to neutralize the ruthenium complex (IA). In this case, Z is Cl. - , O.H. - , C1 to C4-alkoxides, C1 to C4-carboxylates, BF4 - or PF6 - Or two Zs together form SO4 2- The non-coordinating anion Z is particularly preferably Cl - , methoxide, acetate, BF4 - or PF6 - is.

[0094] In particular, the ruthenium complex (IA) (a) Ruthenium complexes of general formula (IAa) [Ru(L)X 1+p Y 2-p ]Z p (IAa) (wherein p=0 or 1); (b) Ruthenium complexes of general formula (IAb) [Ru(L)X p Y 2-p ] Z p (IAb) (wherein p=0 or 1); (c) Ruthenium complex (IAc) of general formula (IAc) [Ru(L)X p Y 2-p ]2Z 2p (IAc) (wherein p=0 or 1); (d) Ruthenium complexes of the general formula (IAd) [Ru(L)X p+1 Y 1-p ]2Z 2p (IAd) (wherein p=0 or 1); (e) Ruthenium complex (IAe) of general formula (IAe) [Ru(L)X p Y 3-p ]Z p (IAe) (wherein p=0 or 1); (f) Ruthenium complex (IAf) of general formula (IAf) [Ru(L)X p Y 2-p ]Z 1+p (IAf) where p=0 or 1; and (g) Ruthenium complex (IAg) of the general formula (IAg) [Ru(L)X p-1 Y 3-p ]2Z 2p (IAg) (wherein p=1); (h) Ruthenium complex (IAh) of general formula (IAh) [Ru(L)X p Y 2-p ]2Z 2p (IAh) wherein p=1.

[0095] [Ru(L)(PPh3)Cl2][Ru(L)(PPh3)Cl(OAc)][Ru(L)(PPh3)Cl2] Ru(L)(PPh3)(H)(Cl)]、[Ru(L)(PPh3)(OAc)2]、[Ru(L)(PPh3)acac(H)]、[ Ru(L)(PPh3)(H)(OMe)]、[Ru(L)(PPh3)(H)2]、[Ru(L)(CO)(H)2][Ru(L)(P Ph3)(H)(OAlkyl)]、[Ru(L)(PPh3)(H)(OAc)]、[Ru(L)(P(o-tolyl)3)Cl2]、 [Ru(L)(P(o-tolyl)3)Cl(OAc)]、[Ru(L)(P(o-tolyl)3)(H)(Cl)]、[Ru(L) (P(o-tolyl)3)(OAc)2]、[Ru(L)(P(o-tolyl)3)acac(H)]、[Ru(L)(P(o-tol) yl)3)(H)(OMe)]、[Ru(L)(P(o-tolyl)3)(H)]OMe、[Ru(L)(P(o-tolyl)3)( H)2]、[Ru(L)(P(o-tolyl)3)(H)(OAlkyl)]、[Ru(L)(P(o-tolyl)3)(H)(OAc )]、[Ru(L)(P(p-tolyl)3)(Cl)2]、[Ru(L)(P(p-tolyl)3)Cl(OAc)]、[Ru(L )(P(p-tolyl)3)(H)(Cl)]、[Ru(L)(P(p-tolyl)3)(OAc)2]、[Ru(L)(P(p-to lyl)3)acac(H)]、[Ru(L)(P(p-tolyl)3)(H)(OMe)]、[Ru(L)(P(p-tolyl)3 )H2]、[Ru(L)(P(p-tolyl)3)(H)(OAlkyl)]、[Ru(L)(P(p-tolyl)3)(H)(OAc )]、[Ru(L)(PCy3)Cl2]、[Ru(L)(PCy3)Cl(OAc)]、[Ru(L)(PCy3)(H)(Cl)]、 [Ru(L)(PCy3)(OAc)2]、[Ru(L)(PCy3)acac(H)]、[Ru(L)(PCy3)(H)(OMe)]、 [Ru(L)(PCy3)H2]、[Ru(L)(PCy3)(H)(OAlkyl)]、[Ru(L)(PCy3)(H)(OAc)] 、[Ru(L)(PtBu3)Cl2]、[Ru(L)(PtBu3)Cl(OAc)]、[Ru(L)(PtBu3)(H)(Cl)]、[Ru(L)(PtBu3)(OAc)2], [Ru(L)(PtBu3)acac(H)], [Ru(L)(PtBu3)(H)(OMe)]. 3)(H)(OAlkyl)], [Ru(L)(PtBu3)(H)(OAc)]. [Ru(L)(CO)(H)(OMe)], [Ru(L)(P(OR)3)(H)2], [Ru(L)(P (OR)3)(H)(Cl)], [Ru(L)(P(OR)3)(OAc)2](also, R remains Methane, dioxide, tert-metal, o-tolyl, p-toly l and 2,4-dimer is 2,4-di-tert-dimer) [Ru(L)(P(O). R)3)acac], [Ru(L)(NHC)Cl2], [Ru(L)(NHC)(OAc)2], [Ru(L)(NHC)acac], [Ru(L)(PPh3)(CO)(H)]Cl, [Ru(L)(PPh3) (CO)(H)]OAc、[Ru(L)(P(o-tolyl)3)(CO)(H)]Cl、[Ru(L)(P(o-tolyl)3)(CO)(H)]OAc、[Ru(L)(P(p-tolyl)3)(CO)( H)]Cl、[Ru(L)(P(p-tolyl)3)(CO)(H)]OAc、[Ru(L)(PCy3)(CO)(H)]Cl、[Ru(L)(PCy3)(CO)(H)]OAc、[Ru(L)(PtBu3) (CO)(H)]Cl and [Ru(L)(PtBu3)(CO)(H)]OAc and [Ru(L)(CO)C l2] (also, L is the smooth surface of (IIa) and (IIb) is (IIc)).

[0096] Preferred examples of ruthenium complexes (IAb) are [Ru(L)H2], [Ru(L)Cl2], [Ru(L)OAc2], [Ru(L)H(OMe)], [Ru(L)H(OAlk)], [Ru(L)(H)acac], [Ru(L)(H)(Cl)], [Ru(L)(H)OAc], [Ru(L)(PPh3)OAc]Cl, [Ru(L)(PPh3)(OMe)]Cl, [Ru(L)(PPh3)(OMe)]OAc, [Ru(L)(PPh3)(H)]OAc, [Ru(L)(PPh3)(H)]OMe, [Ru(L)(CO)(H)]OMe, [Ru(L)(CO)(H)]OAc and [Ru(L)(PPh3)Cl]OAc (wherein L is in each case a neutral ligand (IIa), (IIb) or (IIc)).

[0097] Preferred examples of ruthenium complexes (IAc) are [Ru(L)(PPh3)Cl]2Cl2, [Ru(L)(Cl)2]2, [Ru(L)(OMe)2]2) where L is in each case a neutral ligand (IIa), (IIb) or (IIc) or [Ru(L)(OMe)2] 2、 There is also [Ru(L)(Cl)], where L is in each case an anionic ligand (IId).

[0098] Preferred examples of ruthenium complexes (IAd) are [Ru(L)(H)(PPh3)]2, [Ru(L)(H)(CO)]2, [Ru(L)(Cl)(CO)]2, [Ru(L)(Cl)(PPh3)]2, and [Ru(L)(OMe)(CO)]2, where L is in each case the anionic ligand (IId).

[0099] Preferred examples of ruthenium complexes (IAe) include [Ru(L)(PPh3)(Cl)2]BF4, [Ru(L)(PPh3)(Cl)2]PF6, [Ru(L)(PPh3)(Cl)2]OAc, [Ru(L)(PPh3)(Cl)2]acac, [Ru(L) (PPh3)(H)(Cl)]BF4, [Ru(L)(PPh3)(H)(Cl)]PF6, [Ru(L)(PPh3)(H)(Cl)]OAc, [Ru(L)(PPh3)(H)(Cl)]OMe, [Ru(L)(CO)(H)(Cl)]BF4, [Ru(L) (CO)(H)(Cl)]PF, [Ru(L)(CO)(H)(Cl)]OAc, [Ru(L)(CO)(H)(Cl)]OMe, [Ru(L)(CO)(Cl)]BF, [Ru(L)(CO)(Cl)]PF, [Ru(L)(CO)(Cl)]OAc, [Ru(L)(CO)(Cl)]OMe, [Ru(L)(OAc)]BF, [Ru(L)(OAc)]PF and [Ru(L)(OAc)]OAc, where L is in each case a neutral ligand (IIa), (IIb) or (IIc).

[0100] Preferred examples of ruthenium complexes (IAf) are [Ru(L)(PPh3)(CF3SO3)](CF3SO3)2, [Ru(L)(CO)(Cl)](OAc)2, [Ru(L)(OAc)2](OAc) and [Ru(L)(Cl)2](Cl), where L is in each case a neutral ligand (IIa), (IIb) or (IIc).

[0101] Preferred examples of ruthenium complexes (IAg) are [Ru(L)(Cl)](BF) and [Ru(L)(Cl)](PF), where L is in each case a neutral ligand (IIa), (IIb) or (IIc).

[0102] Preferred examples of ruthenium complexes (IAh) are [Ru(L)(PPh3)(Cl)]2(BF4)2, [Ru(L)(PPh3)(Cl)]2(PF6)2, [Ru(L)(PPh3)(Cl)]2(OAc)2, [Ru(L)(PPh3)(Cl)]2(acac)2, [Ru(L)(CO)(Cl)]2(BF4)2, [Ru(L)(CO)(Cl)]2(PF6)2, [Ru(L)(CO)(Cl)]2(OAc)2, [Ru(L)(CO)(Cl)]2(acac)2, where L is in each case an anionic ligand (IId).

[0103] Particularly preferred ruthenium complexes (IA) are the ruthenium complexes (IAa) and (IAc).

[0104] The method according to the present invention comprises: - the ligand (II) is the ligand (IIa), (IIb) or (IIc), -R 1 and R 2 the radicals are in each case phenyl, p-tolyl, 3,5-dimethyl-4-methoxyphenyl, isobutyl or cyclohexyl, -R 5 and R 10 groups are each independently hydrogen, methyl, or tert-butyl; -R 11 groups are each independently hydrogen, methyl, or methoxy; -R 7 , R 8 and R 9 groups are each independently hydrogen or methyl; - The ruthenium complex (I) is [Ru(L)(PPh3)Cl2], [Ru(L)(PPh3)(H)(Cl)], [Ru(L)(PPh3)(OAc)2], [Ru(L)(PPh3)H(acac)], [Ru(L)(PPh3)(H)(OMe)], [Ru(L)(PPh3)(H)]OMe, [Ru(L)(P(o-tolyl)3)Cl2], [Ru(L)(P(o-tolyl)3)Cl(OAc)], [Ru(L)(P(o-tolyl)3)(H)(Cl)], [Ru(L)(P(o-tolyl)3)(OAc)2], [Ru(L)(P(o-tolyl)3)acac], [Ru(L)(P(o-tolyl)3)(H)(OMe)], [Ru(L)(P(p-tolyl)3)Cl2], [Ru(L)(P(p-tolyl)3)Cl(OAc)], [Ru(L)(P(p-tolyl)3)(H)(Cl)], [Ru(L)(P(p-tolyl)3)(OAc)2], [Ru(L)(P(p-tolyl)3)acac], [Ru(L)(P(p-tolyl)3)(H)(OMe)], [Ru(L)(PCy3)Cl2], [Ru(L)(PCy3)Cl(OAc)], [Ru(L)(PCy3)(H)(Cl)], [Ru(L)(PCy3)(OAc)2], [Ru(L)(PCy3)acac], [Ru(L)(PCy3)(H)(OMe)], [Ru(L)(PtBu3)Cl2], [Ru(L)(PtBu3)Cl(OAc)], [Ru(L)(PtBu3)(H)(Cl)], [Ru(L)(PtBu3)(OAc)2], [Ru(L)(PtBu3)acac], [Ru(L)(PtBu3)(H)(OMe)], [Ru(L)(P(OR)3)(OAc)2], [Ru(L)H(OMe)], [Ru(L)H(OAlk)], [Ru(L)(P(OR)3)acac], [Ru(L)(NHC)Cl2], [Ru(L)(NHC)(OAc)2], [Ru(L)(NHC)acac], [Ru(L)(PPh3)OAc]Cl, [Ru(L)(PPh3)(OMe)]Cl, [Ru(L)(PPh3)(OMe)]OAc, [Ru(L)(PPh3)Cl]OAc, [Ru(L)(PPh3)(Cl)]2OAc2, [Ru(L)(PPh3)(Cl)]2Cl2, [Ru(L)(Cl)2]2, [Ru(L)(OAc)2]2, [Ru(L)(OMe)2]2,It is particularly preferably carried out in the presence of a ruthenium complex (I) having the composition [Ru(L)(H)(Cl)] or [Ru(L)(H)(OAc)].

[0105] The ruthenium complex (I) to be used in the method according to the invention can be obtained in various ways. As a ruthenium-containing starting material, one preferred possibility is to use a compound in which ruthenium is already present in the form of a complex (hereinafter referred to as Ru precursor complex (IV)) and react this with the ligand L. Therefore, a method in which the ruthenium complex (I) is obtained by reacting the ligand (II) with the Ru precursor complex (IV) is preferred.

[0106] In principle, a wide variety of Ru complexes may be used as the Ru precursor complex (IV). Ru precursor complexes (IV) are typically penta- or hexacoordinate ruthenium complexes, which may be bridged to form dimers or trimers. The oxidation state of ruthenium is preferably 0, +2, or +3. Therefore, Ru precursor complexes (IV) contain neutral and / or anionic ligands, and, if necessary, one or more non-coordinating anions to achieve a total charge of "0." In many cases, it is not necessary for Ru precursor complexes (IV) to already contain the ligands X and Y and the non-coordinating anion Y of the desired ruthenium complex (I). The ligands X and Y and the non-coordinating anion Y can often be added separately in the synthesis. To keep synthesis costs low, readily accessible or readily available complexes are advantageously used as the Ru precursor complex (IV). Such complexes are well known to those skilled in the art. Those skilled in the art are familiar with ligand exchange in ruthenium-containing complexes.

[0107] In principle, all neutral ligands already listed under ligand X are suitable as the neutral ligand in the Ru precursor complex (IV), although two X ligands may of course be bonded to each other to form a bidentate ligand in the Ru precursor complex (IV). Furthermore, other neutral ligands not mentioned under X are also possible. Examples here include benzene and p-cymene. Preferred neutral ligands in the Ru precursor complex (IV) include triphenylphosphine, CO, and cycloocta-1,5-diene.

[0108] In principle, all anionic ligands already mentioned for ligand Y are suitable as the anionic ligand in the Ru precursor complex (IV), but of course the anionic ligand Y in the Ru precursor complex (IV) may also be bidentate. Furthermore, other anionic ligands not mentioned for Y are also possible. An example here is methylallyl. Preferred anionic ligands in the Ru precursor complex (IV) include Cl-, acetylacetonate, and methylallyl.

[0109] The reaction of Ru precursor complex (IV) with ligand L is typically carried out at a Ru / L molar ratio of 0.8 to 20, preferably 0.9 to 10, and particularly preferably 0.9 to 1.1. To achieve the highest possible conversion, it is advantageous to use only monodentate and bidentate ligands with Ru precursor complex (IV) and utilize the complexing effect of the tridentate ligand L. The reaction is anhydrous, but is usually carried out in the presence of a solvent under a protective gas atmosphere. Suitable solvents include, for example, aliphatic alcohols such as methanol, ethanol, or isopropanol, and aromatic hydrocarbons such as toluene or xylene. Generally, ruthenium in Ru precursor complex (IV) has the same oxidation state as that in the subsequent ruthenium complex (I), and therefore preferably has an oxidation state of +2 or +3.

[0110] The ruthenium complex (I) may be isolated from the resulting reaction mixture, for example, by precipitation or crystallization.

[0111] However, in order to carry out the hydrogenation according to the present invention, it is generally not necessary to first isolate the ruthenium complex (I) after its preparation. Rather, it is advantageous in terms of a simplified procedure to prepare the ruthenium complex (I) as described above from the Ru precursor complex (IV) and the ligand L in the presence of a solvent, and then carry out the hydrogenation according to the present invention directly in the resulting reaction mixture.

[0112] The esters to be used in the process according to the invention may be of a variety of nature: in principle, it is therefore possible to use linear or branched, acyclic or cyclic, saturated or unsaturated, aliphatic, aromatic or araliphatic esters of various molar masses, from low to high, which are unsubstituted or interrupted by heteroatoms or functional groups.

[0113] The esters used are preferably esters of general formula (III)

[0114] [ka] (In the formula, R a and R b groups are each independently a carbon-containing organic, linear or branched, acyclic or cyclic, saturated or unsaturated, aliphatic, aromatic or araliphatic group, which is unsubstituted or interrupted or substituted by heteroatoms or functional groups, and has a molar mass of 15 to 10000 g / mol, and two groups R a and R b may be bonded to each other) is.

[0115] Branched R a and R bIn the case of groups, they may be branched one or more times. Similarly, in the case of cyclic groups, they may be monocyclic or polycyclic. Similarly, in the case of unsaturated groups, they may be mono- or polyunsaturated, where both double and triple bonds are possible. Heteroatoms should be understood as atoms other than carbon and hydrogen. Preferred examples of heteroatoms include oxygen, nitrogen, sulfur, phosphorus, fluorine, chlorine, bromine, and iodine, and particularly preferred examples are oxygen, nitrogen, fluorine, chlorine, and bromine. A functional group is another description of a group containing at least one heteroatom. For example, a hydrocarbon chain interrupted by -O- can be considered both as a hydrocarbon chain interrupted by an oxygen heteroatom and as a hydrocarbon chain interrupted by an ether group. Other non-limiting examples are amino groups (-NH, -NH-, -N<), aldehyde groups (-CHO), carboxyl groups (-COOH), amide groups (-CONH, -CONH-, -CON<), nitrile groups (-CN), isonitrile groups (-NC), nitro groups (-NO), sulfonic acid groups (-SO), keto groups (>CO), imino groups (>CNH, >CN-), ester groups (-CO-O-), anhydride groups (-CO-O-CO-) and imide groups (-CO-NH-CO-, -CO-NR-CO-). Of course, more than one so-called functional group may also be present. Examples here include fats.

[0116] R a and R b When the groups are linked together, they are cyclic esters, also called lactones.

[0117] R a and R b The molar mass of the radical is generally from 15 to 10 000 g / mol, preferably from 15 to 5000 g / mol, particularly preferably from 15 to 2000 g / mol.

[0118] In the process according to the invention, preference is given to using esters having a molar mass of from 74 to 20 000 g / mol, particularly preferably from 74 to 10 000 g / mol, particularly preferably from 74 to 5 000 g / mol, in particular from 74 to 2 000 g / mol and in particular from 74 to 1 000 g / mol.

[0119] The molecular hydrogen (H2) to be used in the method according to the present invention may be supplied undiluted or diluted with an inert gas, such as nitrogen. It is advantageous to supply a hydrogen-containing gas with the highest possible hydrogen content. A hydrogen content of 80% by volume or more, particularly preferably 90% by volume or more, particularly preferably 95% by volume or more, and in particular 99% by volume or more is preferred.

[0120] In a very general embodiment of the process according to the invention, the ruthenium complex (I), the ester to be hydrogenated and hydrogen are fed to a suitable reactor and the mixture is reacted under the desired reaction conditions.

[0121] The reactor used in the process according to the invention may in principle be any reactor suitable for gas / liquid reactions at the specified temperature and pressure. Standard reactors suitable for gas / liquid and liquid / liquid reaction systems are described, for example, in KD Henkel, "Reactor Types and Their Industrial Applications", Ullmann's Encyclopedia of Industrial Chemistry, 2005, Wiley-VCH Verlag GmbH & Co. KGaA, DOI: 10.1002 / 14356007.b04_087, Chapter 3.3 "Reactors for gas-liquid reactions". Examples include stirred tank reactors, tubular reactors or bubble column reactors. Pressure-resistant stirred tanks are also commonly called autoclaves.

[0122] The ruthenium complex (I) may be fed directly to the reactor in the form of a pre-synthesized ruthenium complex (I), but this requires prior synthesis, subsequent work-up or isolation, and handling under a protective gas atmosphere.

[0123] It is much simpler and more preferable to form the ruthenium complex (I) in situ from the Ru precursor complex (IV) and the ligand L(II). In situ means that the ruthenium complex (I) is formed by feeding the Ru precursor complex (IV) and the ligand L(II) into a reactor. For this purpose, a molar ratio of the ligand L(II) to ruthenium of 0.5 to 5, preferably 0.8 or more, particularly preferably 1 or more, preferably 3 or less, particularly preferably 2 or less, and particularly preferably 1.5 or less is advantageously used. This in situ variant eliminates the need for prior isolation of the ligand (II).

[0124] Another, much simpler possibility for the in situ preparation of ruthenium complex (I) is to form the ruthenium complex (I) from the Ru precursor complex (IV) and the ligand L(II) synthesis unit without isolation or purification. From the ligand L(II) synthesis unit, the ligand (II) is first formed, which then coordinates to ruthenium to give the ruthenium complex (I). Thus, the ruthenium complex (I) can be (a) an aldehyde or ketone of general formula (Va)

[0125] [ka] and an amine of general formula (Vb)

[0126] [ka] and / or (b) an amine of general formula (VIa)

[0127] [ka] with an aldehyde or ketone of general formula (VIb)

[0128] [ka] The reaction gives the ligand L(II) (wherein R 1 From R 11 It is particularly preferred that the ligand L(II) is formed in situ by reacting the formed ligand L(II) with the Ru precursor complex (IV) without subsequent isolation or purification thereof (the groups each having the meaning defined above).

[0129] The process according to the present invention can be carried out in the presence or absence of a solvent. When a solvent is used, it serves, for example, to dissolve the ruthenium complex (I) or the Ru precursor complex (IV) and the ligand L, but also optionally to dissolve the ester to be hydrogenated. In particular, in the case of low molecular weight esters, the ester may also function as a solvent.

[0130] When using a solvent, it is preferred that the solvent does not hydrogenate itself under the reaction conditions and has a generally clear polarity.Preferred examples include aliphatic alcohols, such as methanol, ethanol or isopropanol, and aromatic hydrocarbons, such as toluene or xylene.The amount of solvent used can vary widely.However, the amount is usually in the range of 0.1 to 20 g of solvent per 1 g of ester to be hydrogenated, preferably 0.5 to 10 g of solvent per 1 g of ester to be hydrogenated, particularly preferably 1 to 5 g of solvent per 1 g of ester to be hydrogenated.

[0131] The ester to be hydrogenated may be fed directly in the form of a pure, undiluted ester, or it may be diluted or dissolved in a solvent. The form in which the ester to be hydrogenated is added is often determined by purely practical considerations, such as the nature of the ester present and how it can be handled. For example, the aim is that the ester in the reaction mixture is in liquid form under the reaction conditions.

[0132] The molar ratio between the ester to be hydrogenated and the ruthenium complex (I) may vary widely in the process according to the invention. Generally, the molar ratio specified in the reaction mixture to be hydrogenated is from 1 to 100,000, preferably from 10 to 25,000, particularly preferably from 100 to 5,000, and particularly preferably from 500 to 20,000.

[0133] The process according to the invention is carried out at temperatures of from 50 to 200° C., preferably at or below 170° C., particularly preferably at or below 150° C. In this case, the pressure is from 0.1 to 20 MPa abs, preferably at or above 1 MPa abs, particularly preferably at or above 5 MPa abs, preferably at or below 15 MPa abs, particularly preferably at or below 10 MPa abs.

[0134] The reaction time or average residence time during which the reaction mixture is under reaction conditions may also vary widely, but is typically in the range of 0.1 to 100 hours, preferably 1 hour or more, particularly preferably 2 hours or more, and preferably 80 hours or less, particularly preferably 60 hours or less.

[0135] Furthermore, it has been shown that the hydrogenation according to the present invention is generally positively affected by the presence of a base, resulting in significantly higher final conversion.Therefore, in most cases, it is advantageous to carry out the hydrogenation in the presence of a base.In exceptional cases, for example, when the starting material is unstable to a base or when a secondary reaction occurs with the base under the reaction conditions, the reaction regime may be more advantageous overall without a base.In principle, the base can be present in the reaction mixture as a solid, but it is preferred that the base be present in the reaction mixture in dissolved form.Examples of possible bases include alkoxides, hydroxides, carbonates of alkali metals and alkaline earth metals, amides, basic aluminum, and silicon compounds, as well as hydrides.The base used is particularly preferably an alkoxide or amide, preferably sodium methoxide, potassium methoxide, sodium hydroxide, sodium borohydride or sodium hydride, especially sodium methoxide and potassium methoxide.

[0136] When the process according to the invention is carried out in the presence of a base, the base is generally used in excess relative to the ruthenium complex (I). It is preferable to use a molar ratio of base to ruthenium complex (I) of 2 to 1000, preferably 10 or more, particularly preferably 20 or more, particularly preferably 50 or more, preferably 500 or less, particularly preferably 250 or less.

[0137] The process according to the invention may be carried out continuously, in semi-batch mode, discontinuously, with backmixing in the product as solvent, or in a single pass without backmixing. The ruthenium complex, the ester to be hydrogenated, hydrogen, optionally the solvent, and optionally the base may be fed simultaneously or separately from one another.

[0138] In a discontinuous mode of operation, the ruthenium complex (I) or Ru precursor complex (IV) and the ligand L (II), the ester to be hydrogenated, optionally a solvent and a base, are typically first placed in a reactor, and the desired reaction pressure under the desired reaction conditions is set by adding hydrogen and mixing. The reaction mixture is then placed under the desired reaction conditions for the desired reaction time. Optionally, additional hydrogen is metered in. After the desired reaction time has elapsed, the reaction mixture is cooled or decompressed. The corresponding alcohol may be obtained as the reaction product by subsequent workup. The discontinuous reaction is preferably carried out in a stirred tank.

[0139] In a continuous mode of operation, the ruthenium complex (I) or Ru precursor complex (IV) and the ligand L(II), the ester to be hydrogenated, optionally solvent and base, are continuously fed to the reactor and a corresponding amount is continuously withdrawn for workup and isolation of the corresponding alcohol formed.

[0140] The continuous reaction is preferably carried out in a stirred tank or in a stirred tank cascade.

[0141] The hydrogenation product can be separated from the hydrogenation mixture by processes known per se to those skilled in the art, for example by distillation and / or flash evaporation, and the remaining catalyst can be used in further reactions. In the context of preferred embodiments, it is advantageous to avoid the addition of solvents and to carry out the reactions described above in the substrate or product to be converted, optionally in high-boiling by-products as dissolution medium. A continuous reaction regime with homogeneous catalyst reuse or recycling is particularly preferred.

[0142] In the ester hydrogenation according to the invention, terminal -CHOH and terminal -OH groups are formed from the -CO-O-ester group. Thus, in the case of ester (III), two corresponding alcohols R are formed, which correspond to the following reaction scheme: a -CHOH and R b -OH is formed.

[0143] [ka]

[0144] When cyclic esters, so-called lactones, are used, two groups R a and R b are linked together to form the corresponding diol.

[0145] The process according to the invention allows the preparation of alcohols in high yield and selectivity by homogeneously catalyzed hydrogenation of esters. The hydrogenation may be carried out technically in conventional laboratory equipment for hydrogenation reactions, allowing the use of a wide variety of esters as substrates.

[0146] The particular advantages of the process according to the present invention are based on the specific tridentate PNN ligand. Due to its tridentate nature, the ligand coordinates tightly to ruthenium, but has a much lower molar mass compared to other tridentate ligands of the prior art. For example, the ligand according to the present invention has only one phosphorus atom, which is advantageous in terms of both production costs and subsequent disposal. After forming the corresponding ruthenium complex, the ligand according to the present invention provides a catalyst with high hydrogenation activity. Furthermore, the ligand according to the present invention is relatively insensitive to oxidation, which results in advantageous handling and high storage stability.

[0147] Particular advantages of the ligands according to the invention include, inter alia, their easy accessibility and the possibility of easily modifying the basic structure by replacing hydrogen atoms with various organic groups. The ligands can generally be prepared from readily available raw materials by a simple one-pot synthesis. Isolation of the ligands is generally not required. Rather, the synthesis of the ligands and even the preparation of the ruthenium complexes can be carried out by direct preparation in an autoclave (without isolating intermediates) prior to hydrogenation. Ruthenium precursor complexes, which are easily accessible and commercially available in large quantities, can also be used as ruthenium-containing raw materials. [Example]

[0148] The abbreviations shown in Tables 1 to 4 are used in the following examples.

[0149] [Example 1] Example 1 describes the preparation of various ligands in the form of Examples 1.1 to 1.8. Example 1.1 (Preparation of Ligand 1 = L1)

[0150] [ka] L1 was prepared as described by Rigo et al., Organometallics, 2007, 26, 5636-5642. 31 P-NMR (203 MHz, CD2Cl2) δ -13.9.

[0151] Example 1.2 (Preparation of Ligand 3 = L3)

[0152] [ka] (2-(Diphenylphosphaneyl)phenyl)methanamine (amine A, 1.00 g, 3.43 mmol) was added to a solution of picolinaldehyde (aldehyde A, 368 mg, 3.43 mmol) in ethanol (10 mL) at room temperature, and the resulting mixture was stirred at room temperature for 2 h. NaBH (208 mg, 5.49 mmol) was added, and the mixture was stirred at room temperature for an additional 2 h. Saturated aqueous NaHCO (15 mL) and CHCl (25 mL) were then added. After phase separation, the aqueous phase was extracted with CHCl (2 × 25 mL). The combined organic phases were dried (NaSO) and concentrated in vacuo. The crude product was purified by column chromatography on silica gel (using a mixture of hexane / EtOAc / NEt3, 9:1 to 1:1; 10% NEt3 in EtOAc) to give N-(2-(diphenylphosphaneyl)benzyl)-1-(pyridin-2-yl)methanamine (L3) as a colorless oil (600 mg, 46% yield). 1 H NMR (500 MHz, CD2Cl2) δ 8.48-8.46 (m, 1H), 7.57 (td, J = 7.7, 1.8 Hz, 1H), 7.54-7.51 (m, 1H), 7.36-7.30 (m, 7H), 7.28-7.24 (m, 4H), 7.19-7.10 (m, 4H), 6.91 (ddd, J = 7.7, 4.5, 1.4 Hz, 1H), 4.02 (d, J = 1.7 Hz, 2H), 3.79 (s, 2H). 31 P NMR (203 MHz, CD2Cl2) δ -15.94. HRMS (ESI) C 25 H 23 N2P ([M] + ): Calculated value: 382.1599; Measured value: 382.1611.

[0153] Example 1.3 (Preparation of Ligand 4 = L4)

[0154] [ka] (2-(Diphenylphosphaneyl)phenyl)methanamine (amine A, 1.53 g, 5.25 mmol) was added to a solution of 6-methylpicolinaldehyde (aldehyde B, 636 mg, 5.25 mmol) in ethanol (20.0 mL) at room temperature, and the resulting mixture was stirred at room temperature for 2 h. NaBH (318 mg, 8.41 mmol) was added, and the mixture was stirred at room temperature for an additional 2 h. Saturated aqueous NaHCO (50 mL) and CHCl (50 mL) were then added. After phase separation, the aqueous phase was extracted with CHCl (2 × 25 mL). The combined organic phases were dried (NaSO) and concentrated in vacuo. The crude product was purified by column chromatography on silica gel (using a mixture of hexane / EtOAc / NEt3, 9:1 to 6:4; 10% NEt3 in EtOAc) to give N-(2-(diphenylphosphaneyl)benzyl)-1-(6-methylpyridin-2-yl)methanamine (L4) as a colorless oil (1.23 mg, 3.10 mmol, 59% yield). 1 H NMR (500 MHz, CD2Cl2) δ 7.54-7.52 (m, 1H), 7.46 (t, J = 7.7 Hz, 1H), 7.36-7.30 (m, 7H), 7.27-7.24 (m, 4H), 7.18-7.15 (m, 2H), 6.98 (d, J = 7.7 Hz, 1H), 6.94 (d, J = 7.7 Hz, 1H), 6.92-6.89 (m, 1H), 4.01 (s, 2H), 3.74 (s, 2H), 2.47 (s, 3H). 31 P NMR (203 MHz, CD2Cl2) δ -16.31. HRMS (ESI) C 26 H2N2P ([M] + ): Calculated value: 396.1755; Measured value: 396.1777.

[0155] Example 1.4 (Preparation of Ligand 5 = L5)

[0156] [ka] (2-(Diphenylphosphaneyl)phenyl)methanamine (amine A, 1.5 g, 5.14 mmol) was added to a solution of 6-methoxypicolinaldehyde (aldehyde C, 706 mg, 5.14 mmol) in ethanol (20 mL) at room temperature, and the resulting mixture was stirred at room temperature for 2 h. NaBH (311 mg, 8.22 mmol) was added, and the mixture was stirred at room temperature for an additional 2 h. Saturated aqueous NaHCO (50 mL) and CHCl (50 mL) were then added. After phase separation, the aqueous phase was extracted with CHCl (2 × 25 mL). The combined organic phases were dried (NaSO) and concentrated in vacuo. The crude product was purified by column chromatography on silica gel (using a mixture of hexane / EtOAc / NEt3, 9:1 to 6:4; 10% NEt3 in EtOAc) to give N-(2-(diphenylphosphaneyl)benzyl)-1-(6-methylpyridin-2-yl)methanamine (L5) as a colorless oil (1.67 mg, 4.06 mmol, 79% yield). 1 H NMR (500 MHz, CD2Cl2) δ 7.56-7.51 (m, 1H), 7.46 (dd, J = 8.2, 7.2 Hz, 1H), 7.39-7.28 (m, 7H), 7.27-7.22 (m, 4H), 7.17 (td, J = 7.5, 1.4 Hz, 1H), 6.90 (ddd, J = 7.7, 4.4, 1.4 Hz, 1H), 6.71 (m, 1H), 6.56 (m, 1H), 4.01 (d, J = 1.8 Hz, 2H), 3.86 (s, 3H), 3.69 (s, 2H). 31 P NMR (203 MHz, CD2Cl2) δ -16.25. HRMS (ESI) C 26 H 25 N2P ([M] + ): Calculated value: 396.1755; Measured value: 396.1767.

[0157] Example 1.5 (Preparation of Ligand 6 = L6)

[0158] [ka] 2-Picolylamine (amine 1, 715 mg, 6.61 mmol) was added to a solution of 2-(dicyclohexylphosphaneyl)benzaldehyde (aldehyde 2, 2.00 g, 6.61 mmol) in ethanol (50 mL) at room temperature, and the resulting mixture was stirred at room temperature for 2 h. NaBH (401 mg, 10.6 mmol) was added, and the mixture was stirred at room temperature for an additional 2 h. Saturated aqueous NaHCO (100 mL) and CHCl (75 mL) were then added. After phase separation, the aqueous phase was extracted with CHCl (2 × 50 mL). The combined organic phases were dried (NaSO) and concentrated in vacuo. The crude product was purified by column chromatography on silica gel (using a mixture of hexane / EtOAc / NEt3, 9:1 to 3:1; 10% NEt3 in EtOAc) to give N-(2-(dicyclohexylphosphaneyl)benzyl)-1-(pyridin-2-yl)methanamine (L6) as a colorless oil (1.3 g, 54% yield). 1 H NMR (500 MHz, C6D6) δ 8.50-8.49 (m, 1H), 7.51-7.79 (m, 1H), 7.44-7.41 (m, 1H), 7.24-7.22 (m, 1H), 7.18-7.17 (m, 1H), 7.14-7.10 (m, 2H), 6.65-6.62 (m, 1H), 4.31 (d, J = 2.1 Hz, 2H), 4.03 (s, 2H), 1.95-1.87 (m, 4H), 1.70-1.53 ​​(m, 9H), 130.-1.00 (m, 11H). 31 P NMR (203 MHz, CD2Cl2) δ -16.66. HRMS (ESI) C 26 H 23 N2P ([M] + ): Calculated value: 394.2538; Measured value: 394.2527.

[0159] Example 1.6 (Preparation of Ligand 7 = L7)

[0160] [ka] 2-Picolylamine (amine 1, 532 mg, 4.92 mmol) was added to a solution of 2-(bis(4-methoxy-3,5-dimethylphenyl)phosphaneyl)benzaldehyde (aldehyde 3, 2.00 g, 4.92 mmol) in ethanol (50 mL) at room temperature, and the resulting mixture was stirred at room temperature for 2 h. NaBH (300 mg, 7.88 mmol) was added, and the mixture was stirred at room temperature for an additional 2 h. Saturated aqueous NaHCO (50 mL) and CHCl (50 mL) were then added. After phase separation, the aqueous phase was extracted with CHCl (2 × 25 mL). The combined organic phases were dried (NaSO) and concentrated in vacuo. The crude product was purified by column chromatography on silica gel (using a mixture of hexane / EtOAc / NEt3, 9:1 to 6:4; 10% NEt3 in EtOAc) to give N-(2-(bis(4-methoxy-3,5-dimethylphenyl)phosphaneyl)benzyl)-1-(pyridin-2-yl)methanamine (L7) as a colorless oil (1.20 g, 50% yield). 1 H NMR (500 MHz, C6D6) δ 8.45-8.44 (m, 1H), 7.63-7.60 (m 1H), 7.40 (ddd, J = 7.6, 4.4, 1.4 Hz, 1H), 7.27 (s, 2H), 7.25 (s, 2H), 7.18-7.17 (m, 1H), 7.09-7.05 (m, 2H), 7.00-6.98 (m, 1H), 6.63-6.60 (m, 1H), 4.26 (d, J = 1.9 Hz, 2H), 3.89 (s, 2H), 3.89 (s, 2H), 3.29 (s, 6H), 2.05 (s, 12H). 31 P NMR (203 MHz, CD2Cl2) δ -17.13. HRMS (ESI) C 26 H 25 N2P ([M] +): Calculated value: 498.2436; Measured value: 498.2441.

[0161] General Procedures 1-5 for Hydrogenation Step 1 (Isolated Ligand)

[0162] [ka] 1,4-DMT = methyl 1,4-dimethyl terephthalate 1,4-BDM = 1,4-benzenedimethanol 4-HMBM = methyl 4-hydroxymethylbenzoate 4-HMBA = 4-hydroxymethylbenzaldehyde

[0163] The selected ligand (as indicated in each example), the selected Ru precursor (as indicated in each example), methyl 1,4-dimethylterephthalate (as indicated in each example), and NaOMe (as indicated in each example) were initially charged into a 100 mL autoclave under protective gas, and 40 mL of toluene was added. The autoclave was sealed, hydrogen pressure of 6.0 MPa abs was applied, and the mixture was heated to the desired reaction temperature at 700 rpm (as indicated in each example). After the desired reaction temperature was reached, a hydrogen pressure of 8.0 MPa abs was set. After the desired reaction time had elapsed at the desired reaction temperature, the autoclave was cooled to room temperature, and the resulting effluent was concentrated. The yield was optionally determined, and the effluent was analyzed by GC (sample dissolved in dioxane). An Optima FFAP column (30 m × 0.25 mm / 0.5 μm; 15 min at 140 °C, then 20 °C / min up to 250 °C; flow rate: 2.0 mL / min; hydrogen as carrier gas) was used. Conversion was determined by GC area %. R (1,4-BDM)=24.9 minutes;t R (4-HMBM)=23.0 min, t R (4-HMBA) = 22.5 min.

[0164] Procedure 2 (without isolating the intermediate of ligand L)

[0165] [ka] The selected amine (as indicated in each example) and the selected aldehyde (as indicated in each example) were initially charged into a 100 mL autoclave under protective gas, and 20 mL of toluene was added. The autoclave was sealed and heated to 110 °C for 2 hours. The autoclave was then cooled to room temperature, and Ru precursor 1 (as indicated in each example), methyl 1,4-dimethyl terephthalate (as indicated in each example), and NaOMe (as indicated in each example) were added. 20 mL of toluene was again added, and a hydrogen pressure of 6.0 MPa abs was applied, and the mixture was heated to 130 °C at 700 rpm. After the internal temperature reached 130 °C, a hydrogen pressure of 8.0 MPa abs was set. After the desired reaction time at 130 °C had elapsed, the autoclave was cooled to room temperature, and the resulting effluent was concentrated. The yield was optionally determined, and the effluent was analyzed by GC (sample dissolved in dioxane). Optima FFAP column (30 m x 0.25 mm / 0.5 μm; 15 min at 140 °C, then 20 °C / min to 250 °C; flow rate: 2.0 mL / min; hydrogen as carrier gas). Conversion was determined by GC area %. R (1,4-BDM)=24.9 minutes;t R (4-HMBM)=23.0 min, t R (4-HMBA) = 22.5 min.

[0166] Step 3 (Screening of isolated ligands / substrates with base)

[0167] The selected ligand (as indicated in each example), the selected Ru precursor (as indicated in each example), the selected ester (as indicated in each example), and KOMe (as indicated in each example) were initially charged into a 100 mL autoclave under protective gas, and 20 mL of toluene was added. The autoclave was sealed, hydrogen pressure of 6.0 MPa abs was applied, and the mixture was heated to the desired reaction temperature at 700 rpm (as indicated in each example). After the desired reaction temperature was reached, a hydrogen pressure of 8.0 MPa abs was set. After the desired reaction time had elapsed at the desired reaction temperature, the autoclave was cooled to room temperature, and an aliquot of the resulting effluent was analyzed by GC. An HP5 column (60 m × 0.25 mm / 1.0 μm; 5 min at 60 °C, then 20 °C / min to 250 °C; flow rate: 2.0 mL / min; helium as carrier gas) was used. Yields by GC were determined using tetrahydropyran (THP) as an internal standard. R (THP)=8.4 minutes;t R (benzyl alcohol) = 13.0 min; t R (methyl benzoate) = 13.6 min.

[0168] Step 4 (Base-free screening of isolated ligands / substrates) Procedure 4 corresponds to procedure 3, except that the reaction was carried out without the addition of KOMe.

[0169] Step 5 (Screening of isolated ligands / substrates) Procedure 5 corresponds to Procedure 3, except that the reaction was carried out in THF instead of toluene as solvent, using different concentration ratios, and NaOMe was used as the base.

[0170] The selected ligand (as indicated in each example), the selected Ru precursor (as indicated in each example), the selected ester (as indicated in each example), and NaOMe (as indicated in each example) were initially charged into a 100 mL autoclave under protective gas, and THF (40 mL) was added. The autoclave was sealed, hydrogen pressure of 6.0 MPa abs was applied, and the mixture was heated to the desired reaction temperature at 700 rpm (as indicated in each example). After the desired reaction temperature was reached, a hydrogen pressure of 8.0 MPa abs was set. After the desired reaction time at the desired reaction temperature had elapsed, the autoclave was cooled to room temperature, and an aliquot of the resulting effluent was analyzed by GC. An Optima FFAP column (30 m × 0.25 mm / 0.5 μm; 140 °C for 5 min, then 15 °C / min to 250 °C; flow rate: 2.0 mL / min; helium as carrier gas) was used. Conversion was determined by GC area %.

[0171] [Example 2] In Example 2, the hydrogenation of methyl 1,4-dimethylterephthalate (1,4-DMT) to 1,4-benzenedimethanol (1,4-BDM) in the presence of ruthenium complexes was investigated using previously synthesized and isolated ligands and various Ru precursors according to Procedure 1. The data for Examples 2.1 to 2.8 are shown in Table 5.

[0172] Using ligands L1, L3 and L4 and Ru precursors 1, 2 and 3, very high conversions of 1,4-DMT up to >98% and very high selectivities to 1,4-BDM up to >98% were achieved.

[0173] [Example 3] In Example 3, the hydrogenation of methyl 1,4-dimethylterephthalate (1,4-DMT) to 1,4-benzenedimethanol (1,4-BDM) in the presence of ruthenium complexes was investigated by preparing different ligands and using different Ru precursors according to Procedure 2 (without isolating the intermediates). The data for Examples 3.1 to 3.5 are shown in Table 6.

[0174] Using amines 1, 2, and 3, aldehyde 1 (from which ligands L1, L2, and L8 are formed), and Ru precursors 1, 3, and 4, extremely high conversions of 1,4-DMT up to >98% and extremely high selectivities to 1,4-BDM up to >98% were achieved.

[0175] [Example 4] In Example 4, the hydrogenation of methyl benzoate to benzyl alcohol was investigated in the presence of Ru complex 1. Ru complex 1 was used according to the method described in the experimental section of P. Rigo et al., Organometallics, 2007, Vol. 26, pp. 5636-5642, entitled "Synthesis of trans-[RuCl(PPh)(b)](1)."

[0176] 36.7 μmol (30 mg) of Ru complex 1, 36.7 mmol of methyl benzoate, and 1.84 mmol of KOMe were initially charged into a 100 mL autoclave under protective gas, and 20 mL of toluene was added. The autoclave was sealed, hydrogen pressure of 6.0 MPa abs was applied, and the mixture was heated to 130 °C at 700 rpm. After reaching 130 °C, hydrogen pressure of 8.0 MPa abs was set. After 16 h at 130 °C, the autoclave was cooled to room temperature, and an aliquot of the resulting effluent was analyzed by GC. An HP5 column (60 m × 0.25 mm / 1.0 μm; 5 min at 60 °C, then 20 °C / min up to 250 °C; flow rate: 2.0 mL / min; helium as carrier gas) was used. Yields by GC were determined using tetrahydropyran (THP) as an internal standard. R (THP)=8.4 minutes;t R (benzyl alcohol) = 13.0 min; t R (methyl benzoate) = 13.6 min.

[0177] The following results were achieved: Methyl benzoate conversion: >99% Selectivity for benzyl alcohol: 99.3% Selectivity for benzaldehyde: 0.74%

[0178] Even when using pre-synthesized ruthenium complexes, extremely high conversions of >99% and selectivities of >99% for benzyl alcohol were achieved in the hydrogenation of methyl benzoate to benzyl alcohol.

[0179] [Example 5] In Example 5, the hydrogenation of various esters in the presence of ruthenium complexes (as shown in Table 7) according to procedures 3, 4 and 5 was investigated using various previously synthesized and isolated ligands and Ru precursors 2, 3 and 5. Table 7 shows the data for Examples 5.1 to 5.17.

[0180] Examples 5.1 to 5.17 show that the process according to the invention is versatile and that the Ru precursors and ligands allow high conversions and high selectivities to the corresponding alcohols when using a wide variety of esters. [Example 6]

[0181] [ka]

[0182] In Example 6, the hydrogenation of (3aR)-(+)-sclareolide to ambroxdiol was investigated.

[0183] In Examples 6.1 and 6.2, Ru complex 1 (as shown in Table 8), (3aR)-(+)-sclareolide (as shown in Table 8), and NaOMe (as shown in Table 8) were initially charged into a 100 mL autoclave under protective gas, and 40 mL of tetrahydrofuran was added. The autoclave was sealed, hydrogen pressure of 6.0 MPa abs was applied, and the mixture was heated at 700 rpm to the desired reaction temperature (as shown in Table 8). After the desired reaction temperature was reached, a hydrogen pressure of 8.0 MPa abs was set. After the desired reaction time had elapsed at the desired reaction temperature, the autoclave was cooled to room temperature, and the resulting solution was analyzed by GC. Optima FFAP column (30 m × 0.25 mm / 0.5 μm; 15 min at 140 °C, then 20 °C / min to 250 °C; flow rate: 2.0 mL / min; helium as carrier gas). R (sclareolide) = 29.4 min; t R (Ambroxidiol) = 32.5 min.

[0184] In Example 6.3, the hydrogenation of (3aR)-(+)-sclareolide to ambroxidiol in the presence of a ruthenium complex was investigated. The procedure was similar to that in Examples 6.1 and 6.2, but in contrast to Examples 6.1 and 6.2, the ligand L3 and Ru precursor 3 were used instead of Ru complex 1.

[0185] Table 8 shows the data for Examples 6.1 to 6.3.

[0186] [Example 7]

[0187] [ka]

[0188] In Example 7, the hydrogenation of isopropyl homofarnesylate to homofarnesol was investigated.

[0189] The Ru precursor 5 (as shown in Table 9) and the ligand L3 (as shown in Table 9) were initially charged into a 100 mL autoclave under protective gas, and 30 mL of methanol was added. The autoclave was sealed, hydrogen pressure of 5.0 MPa abs was applied, and the mixture was heated to 60°C at 700 rpm for 1.5 hours. The pressure was then briefly released again, and NaOMe and isopropyl homofarnesylate dissolved in 10 mL of methanol (as shown in Table 9) were added under an inert atmosphere. The hydrogen pressure was then set to 5.0 MPa, and the autoclave was heated to the desired reaction temperature (as shown in Table 9) at 700 rpm. After the desired reaction temperature was reached, a hydrogen pressure of 8.0 MPa abs was set. After the designated reaction time had elapsed, the autoclave was cooled to room temperature, and the resulting solution was analyzed by GC. VF-23ms column (60 m × 0.25 mm / 0.25 μm; 5 min at 50 °C, then 5 °C / min to 250 °C; flow rate: 1.0 mL / min; helium as carrier gas). R (isopropyl homofarnesylate) = 34.3 min; t R (homofarnesol, sum of four isomers) = 35.1, 35.3, 35.7, 35.8 min.

[0190] Table 9 shows the data for Example 7.

[0191] [Example 8] Example 8 demonstrates the reuse of the catalyst after removing the products from the first hydrogenation by distillation (catalyst recycle).

[0192] 36.7 μmol of L3, 12.2 μmol of Ru precursor 5, and 36.7 mmol of methyl benzoate were initially charged into a 100 mL autoclave under protective gas, and 20 mL of benzyl alcohol was added. The autoclave was sealed, hydrogen pressure of 7.0 MPa abs was applied, and the mixture was heated to 130 °C at 700 rpm. After reaching the reaction temperature, a hydrogen pressure of 8.0 MPa abs was set. After a reaction time of 16 h at 130 °C, the autoclave was cooled to room temperature, and an aliquot of the resulting effluent was analyzed by GC. An HP5 column (60 m × 0.25 mm / 1.0 μm; 5 min at 60 °C, then 20 °C / min up to 250 °C; flow rate: 2.0 mL / min; helium as carrier gas) was used. Yields by GC were determined using tetrahydropyran (THP) as an internal standard. R (THP)=8.4 minutes;t R (benzyl alcohol) = 13.0 min; t R (methyl benzoate) = 13.6 min. Conversion 99.3%; selectivity 95% benzyl alcohol.

[0193] The resulting effluent was concentrated in vacuo and then diluted again with benzyl alcohol to a total volume of 20 mL. The catalyst-containing reaction solution was transferred back to the autoclave under protective gas, and another 36.7 mmol of methyl benzoate was added. A hydrogen pressure of 7.0 MPa abs was applied, and the autoclave was heated to 130°C at 700 rpm. After reaching the reaction temperature, a hydrogen pressure of 8.0 MPa abs was set. After a reaction time of 16 hours at 130°C, the autoclave was cooled to room temperature, and an aliquot of the resulting effluent was analyzed by GC (method as described above). Conversion 97.8%; selectivity 96% benzyl alcohol.

[0194] [Table 1]

[0195] [Table 2]

[0196] Table 3

[0197] Table 4

[0198] Table 5 TIFF0007789566000039.tif244159

[0199] Table 6 TIFF0007789566000041.tif244155

[0200] Table 7 TIFF0007789566000043.tif246161TIFF0007789566000044.tif245153TIFF0007789566000045.tif245153TIFF0007789566000046.tif250153

[0201] Table 8

[0202] Table 9 The following is one embodiment of the present invention. (1) A method for hydrogenating an ester with molecular hydrogen in the presence of a penta- or hexa-coordinated ruthenium complex (I) at a temperature of 50 to 200°C and a pressure of 0.1 to 20 MPa abs to obtain the corresponding alcohol, wherein the ruthenium complex may be bridged to form a dimer, and the ruthenium complex contains a tridentate ligand L of the general formula (II):

change

change

change

change

change

change

Claims

1. A method for hydrogenating an ester with molecular hydrogen in the presence of a penta- or hexa-coordinated ruthenium complex (I) at a temperature of 50 to 200°C and a pressure of 0.1 to 20 MPa abs to obtain the corresponding alcohol, wherein the ruthenium complex may be bridged to form a dimer, and the ruthenium complex contains a tridentate ligand L of the general formula (II): 【Chemistry 1】 (In the formula, R 1 , R 2 are each independently selected from phenyl, benzyl, p-tolyl, m-tolyl, o-tolyl, 4-methoxyphenyl, 2-methoxyphenyl, 1-naphthyl, 2-naphthyl, cyclohexyl, 3,5-dimethyl-4-methoxyphenyl, 3,5-di-tert-butyl-4-methoxyphenyl, and 3,5-dimethylphenyl; R 3 , R 4 , R 5 , R 6 and R 10 are each independently selected from hydrogen and methyl; R 7 , R 8 , R 9 are each independently selected from hydrogen, methyl, ethyl, and n-propyl; R 11 is selected from hydrogen, methyl, ethyl, methoxy, ethoxy and isopropyloxy; n and m each independently represent 0 or 1; A solid-dashed double line represents a single or double bond, provided that: When n=1, both solid-dashed double lines represent single bonds, and m is 1; When n=0, one solid-dashed double line represents a single bond, the other solid-dashed double line represents a double bond, and when the double bond is on the side facing the phenyl ring, m=1, and when the double bond is on the side facing the pyridyl ring, m=0, or both solid-dashed double lines represent single bonds and m is 1. Including, The ester is an ester of general formula (III) 【Chemistry 2】 (In the formula, R a and R b each group is independently a linear or branched, acyclic or cyclic, saturated or unsaturated, aliphatic, aromatic or araliphatic group, which is unsubstituted or interrupted or substituted with heteroatoms or functional groups, said heteroatoms being selected from oxygen, nitrogen, sulfur and phosphorus, and said functional groups being selected from fluorine, chlorine, bromine and iodine; R a and R b The groups each have a molar mass of 15 to 10,000 g / mol and two groups R a and R b may be bonded to each other) That's the method.

2. (i) n and m are 1 in each case and the two solid-dashed double lines represent single bonds, or (ii) n is 0, m is 1 and the solid-dashed double line facing the phenyl ring represents a double bond and the solid-dashed double line facing the pyridyl ring represents a single bond; R 1 and R 2 are both phenyl, p-tolyl, 3,5-dimethyl-4-methoxyphenyl or cyclohexyl; R 3 , R 4 , R 5 , R 6 and R 10 The group is hydrogen, R 11 The group is hydrogen, methyl or methoxy, R 7 , R 8 and R 9 2. The method according to claim 1, wherein a ligand L(II) is used in which the group is hydrogen or methyl.

3. The ruthenium complex (I) contains ruthenium in the oxidation state +2 or +3 and has the general formula (IA) [Ru(L)X a Y b ] p Z (p・c) (IA) (In the formula, X is independently in each occurrence a neutral monodentate ligand, and two ligands X may be combined to form a neutral bidentate ligand; Y in each occurrence is independently an anionic monodentate ligand having a charge of "-1"; Y and X may together be an anionic bidentate ligand having a charge of "-1"; Z is independently in each occurrence a non-coordinating anion having a charge of "-1", and two ligands Z may combine to form a non-coordinating anion having a charge of "-2", a, b, and c are each independently 0, 1, 2, or 3; p is 1 or 2; however, a+b+c is equal to 1, 2, 3, 4, 5 or 6, b and c are determined so that the ruthenium complex (IA) has a total charge of "0" 3. The method of claim 1 or 2, comprising:

4. 4. The method according to claim 1, wherein the ruthenium complex (I) is obtained by reacting the ligand (II) with a Ru precursor complex (IV).

5. R of the ester of general formula (III) a and R b each group is independently a linear or branched, acyclic or cyclic, saturated or unsaturated, aliphatic, aromatic or araliphatic group, which is unsubstituted or interrupted or substituted with heteroatoms or functional groups, said heteroatoms being selected from oxygen and nitrogen, and said functional groups being selected from fluorine, chlorine and bromine; R in formula (III) a and R b The groups each have a molar mass of 74 to 5000 g / mol and the two groups R of the ester of formula (III) a and R b The method of any one of claims 1 to 4, wherein

6. 6. The method according to any one of claims 1 to 5, wherein the ruthenium complex (I) is formed in situ from a Ru precursor complex (IV) and a ligand L(II).

7. The ruthenium complex (I) (a) an aldehyde or ketone of general formula (Va) 【Transformation 3】 and an amine of general formula (Vb) 【Chemistry 4】 and / or (b) an amine of general formula (VIa) 【Transformation 5】 with an aldehyde or ketone of general formula (VIb) 【Transformation 6】 The reaction gives the ligand L(II) (wherein R 1 From R 11 6. The method according to claim 1 , wherein the ligand L(II) is formed in situ by reacting the formed ligand L(II) with the Ru precursor complex (IV) without subsequent isolation or purification thereof (wherein the group L(II) has the meaning defined in claim 1 or 2, respectively).

8. 8. The process according to claim 1, wherein a molar ratio of ester to ruthenium complex (I) of from 100,000 to 1 is used.

9. 9. The process according to any one of claims 1 to 8, wherein the hydrogenation is carried out in the presence of a base.

10. 10. The method of claim 9, wherein an alkoxide or an amide is used as the base.

Images