Biological analysis devices and systems

Abstract

To provide biological analysis devices and systems for simultaneously analyzing a plurality of biological samples.SOLUTION: A biological analysis system can include an excitation module 102 and an emission module 104. The excitation module can include a collimator element 112 for receiving excitation light from an excitation light source 106 and transmitting collimated excitation light in a first direction, and a plurality of excitation mirrors 116 arrayed along an excitation light path, each excitation mirror disposed at an acute angle relative to the first direction and configured to reflect collimated excitation light along a second direction. The emission module can be positioned to receive the excitation light transmitted along the second direction, and includes a plurality of photodetectors 126 configured to receive emission light transmitted from each sample receptacle 120 in a direction transverse to the second direction of the excitation light path.SELECTED DRAWING: Figure 1

Claims

1. A biological analysis system, A first element configured to receive excitation light from at least one excitation light source and to transmit the excitation light along the excitation light path in a first direction, A plurality of excitation mirrors arranged along the excitation light path, each excitation mirror being positioned at an acute angle with respect to the first direction and configured to reflect each beam of excitation light along the second direction of the excitation light path, A sample block comprising multiple sample receptacles, wherein each sample receptacle is positioned to receive a beam of collimated excitation light transmitted along the second direction of the excitation light path, A plurality of photodetectors, each photodetector configured to receive emitted light transmitted from its respective sample receptacle in a third direction, wherein the third direction forms an angle with the second direction of the excitation light path, A biological analysis system equipped with the necessary components.

2. The biological analysis system according to claim 1, wherein the third direction intersects the second direction of the excitation light path.

3. The biological analysis system according to claim 1 or 2, wherein the first element is a collimator element.

4. The biological analysis system according to claim 1 or 2, comprising a plurality of excitation lenses, each excitation lens positioned in the second direction of the excitation light path and configured to focus its respective light beam onto a respective focused excitation light beam received by a respective sample receptacle.

5. The biological analysis system according to claim 4, wherein the excitation lens acts on the incident beam to produce a linearly focused beam.

6. The biological analysis system according to claim 4, wherein the plurality of excitation mirrors are arranged in a staggered diagonal pattern formed by the first center point of the first excitation lens being offset vertically and horizontally from the second center point of the second excitation lens, and the acute angle of each excitation mirror in the staggered diagonal pattern is 50° to 75° with respect to the first direction.

7. The biological analysis system according to claim 1, wherein each photodetector is oriented toward each sample receptacle in the third direction.

8. The biological analysis system according to claim 1, wherein the third direction is orthogonal to the second direction of the excitation light path.

9. The biological analysis system according to claim 1, further comprising a plurality of emission lenses configured to focus the emitted light transmitted in the third direction onto the plurality of photodetectors.

10. The biological analysis system according to claim 9, wherein each emission lens is equipped with a curved lens.

11. The biological analysis system according to claim 9, further comprising a plurality of emission filters corresponding to the plurality of emission lenses, wherein the plurality of emission filters are positioned downstream of the corresponding plurality of emission lenses and are configured to allow emitted light to pass through the emission filters and to block stray excitation light.

12. The biological analysis system according to claim 11, wherein the plurality of emission filters include dual-band stop filters.

13. The biological analysis system according to claim 1, further comprising a plurality of emission windows, each emission window associated with its respective sample receptacle and defining a region in which emitted light is transmitted to a downstream component in the third direction.

14. The biological analysis system according to claim 1, wherein at least one of the plurality of excitation mirrors is independently adjustable.

15. The biological analysis system according to claim 14, wherein the plurality of sample receptacles are arranged in a staggered pattern.

16. A biological analysis system, A first element configured to receive excitation light from at least one excitation light source and to transmit the excitation light in a first direction, A plurality of excitation mirrors, which are optically connected to the first element and configured to transmit excitation light in a second direction, wherein the second direction has a dominant angle greater than 270° with respect to the first direction, A plurality of sample blocks comprising a plurality of sample receptacles, each sample receptacle associated with its respective excitation mirror and positioned to receive light transmitted by its respective excitation mirror along the second direction, A plurality of photodetectors, each photodetector associated with a respective sample receptacle and configured to receive emitted light transmitted from the sample receptacle in a third direction, wherein the third direction is a dominant angle greater than 270° with respect to the second direction, A biological analysis system equipped with the necessary components.

17. The biological analysis system according to claim 16, wherein the first element is a collimator element.

18. The biological analysis system according to claim 16 or 17, comprising a plurality of excitation lenses, each excitation lens positioned in the second direction and configured to focus its respective light beam onto a respective focused excitation light beam received by a respective sample receptacle.

19. A biological analysis system, Light path and A first element configured to receive an excitation light beam from at least one excitation light source and to transmit the excitation light beam along the optical path, The optical path is configured to transmit excitation light to a plurality of excitation mirrors along a first direction, and the first excitation mirror among the plurality of excitation mirrors is spaced a certain distance from the second excitation mirror among the plurality of excitation mirrors when measured along the first direction. The optical path is configured to transmit excitation light from the plurality of excitation mirrors along a second direction, and the second direction has a certain angle with respect to the first direction. The optical path is configured to transmit light along the second direction to a plurality of sample receptacles included in the biological analysis system, each sample receptacle accompanied by its own excitation mirror. The aforementioned optical path is configured to transmit light in a third direction from the sample receptacle to the photodetector associated with the sample receptacle. A biological analysis system.

20. The biological analysis system according to claim 19, comprising a plurality of excitation lenses, each excitation lens positioned in the second direction and configured to focus its respective light beam onto a respective focused excitation light beam received by a respective sample receptacle.

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