Lesion marking system

Abstract

The present invention relates to a lesion marking device and system, comprising: a body; and a fixing part having one side connected to the body and the other side formed to be fixable to a lesion position, wherein the body or the fixing part is formed to include a dye.

Description

Lesion marking system

[0001] The present invention relates to a lesion marking system, and more particularly, to a lesion marking system for fixing a clip containing a dye to a lesion location and enabling the lesion location to be identified during laparoscopic surgery through the clip.

[0002] Typically, an endoscopy is required to remove tumors within the body. If a tumor is discovered during an endoscopy, the location of the tumor is marked for surgical removal.

[0003] Traditionally, open surgery, involving an incision in the abdomen, was the mainstream abdominal surgical technique. This traditional surgical technique remains widely used in modern medicine. However, open surgery carries disadvantages such as the risk of wound infection, slow postoperative recovery, and reduced aesthetic satisfaction due to scarring. As an alternative, laparoscopic gastrotomy, first introduced by Kitano in 1994 for gastric cancer, aims to overcome the aforementioned shortcomings of open surgery by inserting surgical instruments through small incisions in the abdomen. Recently, with the growing interest in aesthetics, the number of laparoscopic surgeries has increased, and laparoscopic instruments and techniques have advanced. Laparoscopic surgery is already recognized as the standard surgical technique for early-stage gastric cancer, and numerous researchers have reported its superiority in advanced gastric cancer. Compared to open surgery, laparoscopic surgery offers several advantages, including less postoperative pain, faster recovery, and superior cosmetic outcomes. However, during surgery, it can be difficult to palpate the lesion manually, and the precise location of the lesion can be challenging due to the use of instruments. In particular, early-stage lesions or benign lesions growing into the intestinal lumen are often not marked by the serosal membrane, making it difficult to determine the lesion's location and determine an appropriate resection margin.

[0004] There have been cases in the past where various methods were used to confirm the location of lesions during laparoscopic surgery.

[0005] In 2005, Hyung WJ et al. introduced a method for identifying lesions using intraoperative laparoscopic ultrasound for gastric submucosal tumors growing into the lumen. This method has the advantage of being easy and safe to perform, but has limitations in that the surgeon must be proficient in the laparoscopic ultrasound technique and the lesion may not be identified due to the small size of the clip. In 2011, Kim HI et al. reported a method for finding clips placed before surgery using intraoperative recovery X-rays in 80 patients with early gastric cancer, and in 2014, Kim BS et al. reported a method for identifying lesions after X-ray acquisition using a radio-opaque gauge. Various methods using upper endoscopy have also been introduced. In 2012, Jeong O. et al. reported an autologous blood tattooing method in which blood was drawn from a patient and injected into the submucosal layer of the stomach through an upper gastrointestinal endoscope before surgery to mark lesions on the serosa. Xuan Y. et al. also introduced a method in which dye was injected into the submucosal layer of the stomach through an endoscope during surgery without installing clips before surgery to identify the location of lesions on the serosa.

[0006] However, the use of clips presents the challenge of requiring additional measures to accurately identify the lesion location. For example, prior to surgery, additional instruments are used to mark the lesion location near the area suspected of being cancerous. (Laparoscopic metal clip -> location identified with a mobile X-ray -> stomach resected along the marked area outside the body.)

[0007] In addition, when marking the location of the lesion with a dye, the dye sample is injected into living tissue, so the dye spreads to the surrounding area, making it difficult to pinpoint the location of the cancer, and thus there is a problem of resecting the stomach by including more normal tissue than necessary.

[0008] Accordingly, the industry is continuously and actively conducting research and development to develop an efficient lesion marking device and system that minimizes the problems of the method for identifying the location of the lesion as described above and the additional measures required after the endoscopy as described above.

[0009] The present invention was created to solve the problems of the prior art as described above, and the purpose of the present invention is to provide a lesion marking system that can prevent the resection of normal cells by including a clip that can be fixed to a lesion location so that the lesion location can be accurately and quickly identified during laparoscopic surgery and can be easily and quickly confirmed through an endoscopic camera.

[0010] The present invention relates to a lesion marking device, comprising: a body part; and a fixing part, one side of which is connected to the body part and the other side of which is formed to be fixable to a lesion location; characterized in that the body part or the fixing part is formed to contain a dye.

[0011] Specifically, the body part or the fixed part may be formed of a material including the dye.

[0012] Specifically, the body part or the fixed part may be coated with the dye.

[0013] Specifically, the body part or the fixed part may have a receiving space formed to receive the dye.

[0014] Specifically, the receiving space may include a hole formed in a cylindrical shape and having one side open to receive the dye; and a stopper that blocks the hole from the outside.

[0015] Specifically, when one side of the hole is in the body part, the other end may be formed only up to the body part or may extend into the fixed part, and when one side is in the fixed part, the other end may be formed only up to the fixed part or may extend into the body part.

[0016] Specifically, the dye may be a solid or liquid and may be capable of fluorescing at near-infrared wavelengths.

[0017] Specifically, the present invention further includes a case for sealing the dye, and the case is formed in a capsule shape and can be inserted into the receiving space.

[0018] Specifically, the case is formed of a flexible material, can be fitted into at least a portion of the receiving space, and can be detached by an external force.

[0019] Specifically, the plug may be spirally connected to the body or formed of a rubber material and fitted.

[0020] Specifically, the receiving space may include a donut-shaped hole and a plug through which a portion of the applier can pass.

[0021] Specifically, at least a portion of the body portion or the fixing portion may be formed transparently so that the dye is projected.

[0022] In addition, the present invention is characterized by comprising a lesion marking system for identifying a lesion location, the lesion marking device according to any one of claims 1 to 12; and an applier for attaching the lesion marking device to the lesion location.

[0023] A lesion marking system according to one embodiment of the present invention has the effect of enabling easy and quick confirmation of the exact location of a lesion during surgery by providing a dye in the clip itself.

[0024] In addition, the lesion marking system according to one embodiment of the present invention has the effect of confining the dye within the clip and preventing it from spreading to normal tissue.

[0025] In addition, the lesion marking system according to one embodiment of the present invention has the effect of minimizing additional measures such as location identification through X-ray by including a dye in the clip that is first installed.

[0026] In addition, the lesion marking system according to one embodiment of the present invention has the effect of enabling easy, quick, and accurate identification of the lesion location by enabling confirmation of the dye through a simple operation of changing the photographing camera used during laparoscopic surgery to near-infrared mode.

[0027] In addition, the lesion marking system according to one embodiment of the present invention is cost-effective for the patient by minimizing additional measures (shortening surgical time, reducing use of unnecessary equipment, and minimizing resection of normal tissue), and has the effect of improving the quality of life of the patient.

[0028] FIG. 1 is a schematic diagram showing a state of use of a clip during endoscopy in a lesion marking system according to an embodiment of the present invention.

[0029] FIG. 2 is a schematic drawing showing the overall shape and cross-section of a clip of a lesion marking system according to an embodiment of the present invention.

[0030] FIG. 3 is a drawing schematically showing the overall shape of a clip and applicator of a lesion marking system according to an embodiment of the present invention.

[0031] FIG. 4 is a drawing schematically showing the shape of a clip when installed using an applier of a lesion marking system according to an embodiment of the present invention.

[0032] FIG. 5 is a schematic drawing showing the shape of a clip of a lesion marking system according to an embodiment of the present invention installed by an applier.

[0033] FIG. 6 is a schematic drawing showing a cross-section of a clip of a lesion marking system according to an embodiment of the present invention.

[0034] The objects, specific advantages, and novel features of the present invention will become more apparent from the following detailed description and preferred embodiments, taken in conjunction with the accompanying drawings. In this specification, when reference numerals are assigned to components in each drawing, it should be noted that, where possible, identical components are given the same reference numerals even if they appear in different drawings. Furthermore, in describing the present invention, if a detailed description of a related known technology is deemed to unnecessarily obscure the gist of the present invention, the detailed description thereof will be omitted.

[0035] Hereinafter, a detailed description will be provided along with the drawings shown below.

[0036] FIG. 1 is a drawing schematically showing a state of use of a clip during endoscopy in a lesion marking system according to an embodiment of the present invention, FIG. 2 is a drawing schematically showing the overall shape and cross-section of a clip in a lesion marking system according to an embodiment of the present invention, FIG. 3 is a drawing schematically showing the overall shape of a clip and an applier in a lesion marking system according to an embodiment of the present invention, FIG. 4 is a drawing schematically showing the shape of a clip when installed using an applier in a lesion marking system according to an embodiment of the present invention, FIG. 5 is a drawing schematically showing the shape of a clip in a lesion marking system according to an embodiment of the present invention installed by an applier, and FIG. 6 is a drawing schematically showing a cross-section of a clip in a lesion marking system according to an embodiment of the present invention.

[0037] According to one embodiment of the present invention, a lesion marking system is provided, which fixes a clip containing a dye to a lesion location so that the lesion location can be accurately identified during laparoscopic surgery, and the dye is made to fluoresce at a specific wavelength so that the surgeon can easily identify the lesion location. Here, a laparoscope is a laparoscope for examining and treating the abdominal cavity and the inside of the abdominal cavity. Specifically, it refers to making a small hole in a place such as the side of the abdomen or the navel, inflating it with air to make it easier to observe, and then examining, operating, and extracting tissue while looking at the inside of the abdominal cavity. Unlike general open surgery, laparoscopic surgery is a surgery performed by making a small incision (0.5 cm to 1.2 cm) in the abdomen, inserting the abdominal cavity, and inserting a laparoscope equipped with a camera through this tube (trocar), and viewing the surgical field of view through a TV monitor, using a surgical instrument that is specially designed to be thin and long for laparoscopic surgery. Laparoscopic surgery became widely used in surgical practice in 1987, when French surgeon Dr. Mouret first performed a laparoscopic cholecystectomy. This recognition of its advantages led to its widespread adoption worldwide. The scope of laparoscopic surgery has recently expanded to cover virtually all surgical conditions. The benefits of laparoscopic surgery include reduced postoperative pain, fewer complications, faster recovery, shorter hospital stays, and an earlier return to daily life and work. This is due to the minimal abdominal incision required and the significant reduction in traction or contact with the abdominal wall or other intra-abdominal organs. This significantly reduces surgical stress compared to open surgery, resulting in a significant reduction in harmful physiological effects. Furthermore, the surgical scars from the 0.5-1.2 cm incisions become indistinguishable over time without careful examination, offering significant cosmetic benefits.Laparoscopic surgery presents significant challenges for the surgeon. This is because the image captured by the laparoscope is viewed as a two-dimensional image on a TV monitor, making it difficult to properly adjust the distance between objects and potentially confusing the sense of direction. Furthermore, the surgical field of view is limited to the area illuminated by the laparoscope. Furthermore, tactile information, such as the ability to feel the surgical site directly, is not available, making it extremely difficult to accurately identify the lesion location. Therefore, preoperative endoscopic marking of the lesion location has recently been adopted. Examples include staining the lesion with indocyanine green (ICG), methylene blue, or autologous blood, or using a simple clip to directly mark the lesion. However, these methods have the disadvantage of resecting normal tissue due to dye spread. Furthermore, using a simple clip alone to mark the lesion location necessitates additional interventions, such as X-rays.

[0038] The present invention proposes a lesion marking system as an alternative to solve the above problems.

[0039] In a lesion marking system for identifying a lesion location using a lesion marking device (100) according to one embodiment of the present invention, the lesion marking device (100) may include a body part (101) having a receiving space formed on one side for receiving a dye; one side of which is connected to the body part (101), and the other side of which is capable of being fixed to a lesion location, a fixing part (102).

[0040] Here, the lesion marking device (100) may be a type of clip widely used in operating rooms, and will be referred to as a clip in the following. The clip (100) may be a means for identifying the lesion location by being fixed to the lesion location when performing an endoscope to accurately identify the lesion location prior to laparoscopic surgery.

[0041] In particular, it may be important for the clip (100) to be accurately identified by the surgeon performing the laparoscopic surgery. To this end, the clip (100) may be at least partially illuminated within the darkened body. For example, the dye contained within the clip (100) may utilize a self-luminous material or a material that appears bright at a specific wavelength.

[0042] In addition, the body part (101) may occupy the largest volume in the clip (100). Accordingly, the dye-containing space formed inside has a large volume compared to the size of the entire clip (100), and thus can be easily confirmed from the outside of the clip (100).

[0043] Here, it may be desirable for the body part (101) or the fixed part (102) in which the receiving space is formed to be formed of a transparent material so that the dye inside the receiving space can be confirmed from the outside.

[0044] Additionally, the receiving space may be formed throughout the entire body portion (101). As the volume of the receiving space increases, the capacity to receive the dye may increase, and accordingly, the volume of the dye exposed to the outside may increase, allowing the operator to easily check it.

[0045] Additionally, the fixed part (102) connected to the body part (101) may be fixed to the affected area by a clamp provided on the other side.

[0046] Specifically, one side is connected to the body (101) so as to be movable, and the two arms of the forceps can be attached and detached like tweezers.

[0047] That is, when two or more forceps formed on the fixed part (102) are formed to attach to each other near the affected area, the shape may be such that the affected area is held together with the attachment of the forceps.

[0048] In addition, the fixing member (102) may be fixed in a state where the movement is fixed while holding the affected area. Accordingly, the clip (100) may be fixed to the lesion location.

[0049] Here, the term "affected area" may be used interchangeably with "lesion location." Specifically, "lesion" refers to the physical or physiological changes caused by the disease, while "lesion location" may refer to the exact location of the lesion or the tissues nearby.

[0050] Meanwhile, the body part (101) or the fixed part (102) may be formed of a material containing a dye. For example, a dye may be added to the material forming the clip (100) so that the clip (100) is manufactured from a material containing a dye.

[0051] Additionally, the body part (101) or the fixed part (102) can be formed so that the outside is coated with a dye.

[0052] Of course, the receiving space can be formed only in the fixed portion (102). However, considering the size of the receiving space, it is preferable that the fixed portion (102) be formed so that the dye is in the form of a coating or as a part of the constituent material, and that the body portion (101) be formed so that a receiving space for receiving the dye is formed.

[0053] The receiving space of the lesion marking system according to one embodiment of the present invention may include a hole formed in a cylindrical shape inside the body part (101) and having one side open to receive the dye; and a stopper (110) that blocks the hole from the outside.

[0054] Here, the hole may have one side open so that dye can be injected. In addition, the hole may preferably be provided in a cylindrical shape, but is not limited thereto, and may vary depending on the shape of the clip (100).

[0055] At this time, the clip (100) should be inserted into the stomach through the patient's mouth when an endoscopy is performed for gastric cancer. Alternatively, it can be inserted through a small incision made in the abdomen. That is, since it is inserted through a small hole, a small volume may be advantageous, and it may be advantageous if sharp shapes on the side are minimized. For this reason, the clip (100) is preferably provided in a cylindrical shape, and accordingly, the shape of the receiving space may also be preferably formed in a cylindrical shape. In addition, the front of the body portion (101) may be preferably provided in a round shape. This part is a part that directly contacts the affected area, and if an angled or sharp part is present, there may be problems such as additional bleeding.

[0056] Additionally, the plug (110) may isolate the hole from the outside. That is, it may block the open portion of the hole from the outside so as to prevent the dye inserted into the hole from leaking or being released to the outside. This is to prevent the dye from leaking out and staining the surrounding normal tissue, and to prevent the operator from confusing the location of the lesion due to the leaked dye.

[0057] The hole of the lesion marking system according to one embodiment of the present invention may have one end blocked by the plug (110) and the other end extended into the interior of the fixing member (102).

[0058] Here, the fixed part (102) refers to a clamp shape, and the space formed inside the fixed part (102) may be provided in a shape that is extended from the hole.

[0059] That is, the dye may be injected not only into the body part (101) where the receiving space is formed, but also into the fixing part (102) so that the operator can easily check it.

[0060] Here, the fixed part (102) may be formed of a transparent material so that the inside can be seen from the outside.

[0061] For example, when one end of the hole is in the body part (101), the other end may be formed only up to the body part (101) or may extend into the fixed part (102), or when one end of the hole is in the fixed part (102), the other end may be formed only up to the fixed part (102) or may extend into the body part (101).

[0062] The dye of the lesion marking system according to one embodiment of the present invention may be a solid or liquid and may be capable of fluorescing at a near-infrared wavelength.

[0063] Here, if the dye is provided in liquid form, the process of inserting it into the clip (100) can be easily performed. However, when the open portion of the hole is blocked from the outside with a stopper (110), the liquid may seep into the gap between the hole and the stopper (110) due to its characteristics.

[0064] In addition, if the dye is provided in a solid form, there may be some difficulty in inserting it into the clip (100). However, when the open portion of the hole is blocked from the outside with a plug (110), the situation where the dye escapes through the gap between the hole and the plug (110) can be minimized due to the nature of the solid.

[0065] A lesion marking system according to one embodiment of the present invention further includes a case for sealing the dye, and the case may be formed in a capsule shape and be insertable into the receiving space.

[0066] Here, the case may be one that maintains the dye in a sealed state. That is, the dye may be inserted into the containing space, sealed in a case formed separately from the containing space. This configuration allows the dye to be incorporated into the case during its manufacturing process, eliminating the need to directly insert the dye into the containing space, and minimizing contamination until it is inserted into the human body.

[0067] Additionally, if the case becomes contaminated, the case itself may be able to be disinfected without affecting the dye.

[0068] According to one embodiment of the present invention, the case is formed of a flexible material, can be fitted into at least a portion of the receiving space, and can be detached by an external force. Here, the case may include a dye, and a case formed of a rubber material may be at least partially pressed. By utilizing this property, the case may be fitted into the receiving space. Specifically, the rear portion of the receiving space (opposite the fixing portion (102)) may be open. In addition, the opened portion may be formed to have a smaller size than the side circumference of the case. Accordingly, when the case is pushed into the receiving space, a portion of the case is pressed, and thus the side circumference diameter may be reduced to some extent, and may be inserted into the receiving space.

[0069] Conversely, a case in a fitted state can be pulled out by an external force, and at this time, the case can be detached by reducing the side circumference diameter of the case by the opened portion of the receiving space in the same manner as when it was joined.

[0070] The plug (110) of the lesion marking system according to one embodiment of the present invention may be spirally connected to the body part (101) or may be formed of a rubber material and fitted.

[0071] Here, the spiral connection may be formed by forming threads on the inner diameter of the hole and the outer diameter of the part inserted into the hole, and the threads may be fitted into each other by the rotation of the plug (110) or the hole. This structure can completely block the outside from the liquid or solid dye while it is sealed in the receiving space.

[0072] Additionally, the stopper (110) may be formed of a rubber material and fitted into the hole. Specifically, a stopper (110) having an outer diameter equal to or slightly larger than the inner diameter of the hole may be inserted into the hole to block the receiving space from the outside. For example, a cork stopper (110) may be used to seal a wine bottle.

[0073] Referring to FIG. 6, in a lesion marking system for identifying a lesion location according to another embodiment of the present invention, a clip (100) is provided that is fixable to the lesion location and has a receiving space (120) formed on one side to receive a dye; an applier (200) that attaches the clip (100) to the lesion location; wherein the receiving space (120) is transparent at least in part so that the dye can be projected, and has a donut shape so that a part of the applier (200) can pass through it, and the dye may be formed as a solid or a liquid and may be capable of fluorescence expression in a near-infrared mode.

[0074] The lesion marking system may be used in an actual laparoscopic surgery field by approaching an applier (200) with a clip (100) loaded near the lesion location and fixing the clip (100) to the lesion location.

[0075] This is a form of simply adding a lesion marking system for laparoscopic surgery that uses an applier (200) to fix a clip (100) to the lesion location in the endoscope insertion step among the steps of puncture - endoscope insertion - lesion confirmation using an endoscope and a probe - lesion resection using a resection instrument, which are steps of the existing laparoscopic surgery process, so it can be said to be suitable for surgeons who are familiar with the existing surgical method (laparoscopic surgery). In addition, compared to the existing laparoscopic surgery marking method, the existing method had many difficulties in actual application because it was greatly affected by the skill of the surgeon or the method was too complicated and required cooperation. Therefore, the lesion marking system for laparoscopic surgery of the present invention was developed in a way that minimizes the dependence on the skill of the surgeon, puts less burden on the body alone, is simple, and increases reliability.

[0076] In particular, the curvature shape of the colon varies from the general normal distribution to Alpha, N, and Reverse Alpha Loop shapes, so the location identified within the lumen may differ from the location viewed from the outside. In addition, it is difficult to tactilely identify lesions in colon tissue during incision surgery, so marking that allows visual identification is essential.

[0077] A clip (100) of a lesion marking system according to one embodiment of the present invention may be provided in a cylindrical shape and may include a body part (101) having a round shape in a portion that comes into contact with a lesion location, and a fixing part (102) formed in a forceps shape so as to be fixed to the lesion location.

[0078] Here, the body part (101) may be formed with a clip (100) frame at the part connected to the applier (200) and a fixing part (102) may be formed to extend from the side toward the front.

[0079] The fixing member (102) may have an open end and a shape in which the other end remains connected. The clamps of the fixing member (102) may each have a curved shape. In addition, the connected portion on the other side may be embedded in the body portion (101). In addition, the clamps of the fixing member (102) may be brought into contact with the other connected portion by pulling it with the applier (200), thereby capturing the lesion position and fixing it to the lesion position.

[0080] After this, the body part (101) can be confirmed from the outside of the clip (100) while the clip (100) is fixed to the lesion location. However, the size of the clip (100) is very small, and since a narrow space is confirmed through the camera, there may be cases where it is missed.

[0081] To prevent this, the receiving space (120) may contain a dye.

[0082] The receiving space (120) of the lesion marking system according to one embodiment of the present invention may be a donut shape with a hole (H) formed in the center.

[0083] In order to move the fixing part (102) of the clip (100), a wire may pass through the inside while connected to the applier (200). For this purpose, the body part (101) may form a space inside, and together with this, the receiving space (120) may have a hole (H) formed therein. That is, a dye may be formed in a part excluding the hole (H) so that the operator can easily check it.

[0084] The applier (200) of the lesion marking system according to one embodiment of the present invention can fix the clip (100) to the lesion location through at least one wire.

[0085] Here, the applier (200) may be equipped with a clip (100) at one end, and the other end may be formed with a control unit that can be operated by the operator.

[0086] Specifically, a wire connected to the operating unit may be formed to penetrate the interior of the applier (200) and may be freely movable. One side of the wire and the fixing unit (102) may be connected. Thereafter, the wire and the fixing unit (102) may be pulled by a pulling movement from the operating unit. The fixing unit (102) pulled by the wire is closed and fixed to the lesion location. The fixed clip (100) may be separated by the operation of the applier (200) and maintained in a fixed state at the lesion location.

[0087] The specific shape of the fixed part (102) is a clamp shape, and is divided into a side where the clamp is opened and a side where it is connected, and may be connected to the wire of the applier (200) and the connected side of the fixed part (102). In addition, the fixed part (102) may be inserted into the interior of the body part (101), and the outer surface of the fixed part (102) may be in contact with the inner surface of the body part (101). Accordingly, when the connected side of the fixed part (102) is pulled, the outer surface of the fixed part (102) may be pushed by the inner surface of the body part (101), thereby closing the fixed part (102).

[0088] Additionally, the applier (200) may be equipped with an endoscopic camera along with a wire connected to the control unit. This may be used to secure a clip (100) to a lesion location identified through the camera during endoscopy, and may be used to identify and resect the lesion location during surgery.

[0089] Additionally, the applier (200) may have a separate camera formed outside the applier (200). In this case, the procedure time may be shortened as the clip (100) can be installed at the lesion location identified by the camera while another location can be identified.

[0090] In addition, the applier (200) may include at least one clip (100). Specifically, a plurality of clips (100) may be connected to a single wire. The hole (H) formed in the body (101) may be provided in a completely penetrating shape and may be in a shape in which the wires penetrate the plurality of clips (100). The wires penetrating the clips (100) may drive the fixing portion (102) of each clip (100) through various methods such as magnetic or ring-shaped. When a plurality of clips (100) are mounted, multiple clips (100) can be fixed with a single endoscope, thereby shortening the procedure time.

[0091] While the present invention has been described in detail through specific embodiments, these are intended to illustrate the present invention in detail. It is to be understood that the present invention is not limited thereto, and that modifications and improvements within the technical scope of the present invention are readily apparent to those skilled in the art. All simple modifications and variations of the present invention fall within the scope of the present invention, and the specific scope of protection of the present invention will be made clear by the appended claims.

Claims

1. Body; and One side is connected to the body part, and the other side includes a fixing part formed to be fixed to the lesion location, A lesion marking device characterized in that the body part or the fixing part is formed to contain a dye.

2. In the first paragraph, the body part or the fixed part, A lesion marking device characterized in that it is formed of a material containing the above dye.

3. In the first paragraph, the body part or the fixed part, A lesion marking device characterized by being coated with the above dye.

4. In the first paragraph, the body part or the fixed part, A lesion marking device characterized in that a receiving space for receiving the dye is formed.

5. In paragraph 4, the accommodation space is: A hole formed in a cylindrical shape and having one side open to receive the dye; and A lesion marking device characterized by including a plug that blocks the hole from the outside.

6. In paragraph 5, the hole, When one end is in the body part, the other end is formed only up to the body part or extends into the inside of the fixed part, A lesion marking device characterized in that when one end is at the fixed portion, the other end is formed only up to the fixed portion or extends up to the body portion.

7. In paragraph 1, the dye, is solid or liquid, A lesion marking device characterized by being capable of fluorescence expression at near-infrared wavelengths.

8. In paragraph 4, Further comprising a case for sealing the dye, The above case is, A lesion marking device characterized in that it is formed in a capsule shape and can be inserted into the receiving space.

9. In paragraph 8, the case, A lesion marking device characterized in that it is formed of a flexible material, can be fitted into at least a portion of the receiving space, and can be detached by an external force.

10. In paragraph 5, the stopper, A lesion marking device characterized in that it is spirally connected to the above body part or is formed of rubber material and fitted.

11. In paragraph 4, the accommodation space is: A lesion marking device characterized by including a donut-shaped hole and a plug so that a portion of the applier can penetrate.

12. In the first paragraph, the body part or the fixed part, A lesion marking device characterized in that at least a portion thereof is formed transparently so that the dye can be projected.

13. In a lesion marking system for identifying lesion locations, A lesion marking device according to any one of claims 1 to 12; and A lesion marking system characterized by including an applier that attaches the lesion marking device to the lesion location.

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