System and method for using color cherenkov imaging and color reflectance imaging to correct and map radiation dosage and monitor radiation damage during radiation treatments

The system addresses inaccuracies in radiation dosimetry by using color Cherenkov and reflectance imaging to correct radiation dosage maps, enhancing the accuracy of dose estimation and toxicity monitoring, thus optimizing cancer treatment.

WO2025006845A1PCT designated stage expired Publication Date: 2025-01-02TRUSTEES OF DARTMOUTH COLLEGE THE
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Patent Information

Application Number
PCT/US2024/035968
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2023-06-28
Filing Date
2024-06-28
Publication Date
2025-01-02

AI Technical Summary

Technical Problem

Current optical imaging methods for radiation dosimetry in cancer treatment face inaccuracies due to photon absorption, scattering, and refraction, leading to uncertainties in radiation dose estimation and tissue toxicity monitoring.

Method used

A system utilizing color Cherenkov imaging and reflectance imaging to correct and map radiation dosage by recording light intensity in multiple spectral bands, applying spectral correction parameters to Cherenkov images, and determining dose correction functions based on tissue optical properties, thereby enhancing the accuracy of radiation dose estimation and monitoring tissue response.

Benefits of technology

This approach improves the accuracy of radiation dose estimation and monitoring, allowing for real-time correction of radiation dosage maps and prediction of radiation toxicity, thereby optimizing cancer treatment outcomes and minimizing tissue damage.

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Abstract

A radiation treatment observation system has a camera configured to image Cherenkov light emissions in multiple spectral bands including a band having a center wavelength between 750 and 900 nanometers from a treatment zone to generate Cherenkov images, and an image processor. The image processor determines Cherenkov spectral correction parameters at pixels of the Cherenkov images based on differences between imaged intensity of Cherenkov light in the spectral bands at pixels of the Cherenkov images, and determines a corrected dosage map of the subject based upon at least the Cherenkov images and the Cherenkov spectral correction parameters. A method of monitoring radiation treatment of diffuse media includes determining surface coloration; determining subsurface optical parameters; and using the surface color and optical parameters, determining dose correction functions. The method includes obtaining and totalizing color Cherenkov images, and using the dose correction function to give corrected dose images.
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Citation Information

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