Topical preparation for skin

Abstract

The present invention provides a topical preparation for skin, which does not emit a smell or undergo discoloration even when being stored at a high temperature, has excellent storage stability, and does not cause sticky feeling during application and after application.　The present invention relates to a topical preparation for skin, which contains the following components (A), (B), and (C): (A) γ-amino-β-hydroxybutyric acid, (B) one or more components selected from osmolytes, and (C) water.

Description

topical skin preparations

[0001] The present invention relates to an external preparation for skin.

[0002] γ-Amino-β-hydroxybutyric acid is used by blending it into cosmetics and the like. For example, Patent Document 1 describes that a skin cosmetic containing γ-amino-β-hydroxybutyric acid has excellent anti-aging effects for skin. Patent Document 2 describes that a skin cosmetic containing γ-amino-β-hydroxybutyric acid and vitamin B6 has excellent anti-skin leveling effects and the durability of these effects. Patent Document 3 describes that a whitening cosmetic containing an extract obtained from Dioscoria composita and medicinal ingredients such as γ-amino-β-hydroxybutyric acid prevents inflammation caused by ultraviolet rays, suppresses melanin production caused by ultraviolet damage, and promotes the excretion of melanin pigment, thereby exhibiting excellent whitening effects in a short period of time.

[0003] Japanese Patent Laid-Open No. 62-255405 Japanese Patent Laid-Open No. 63-10708 Japanese Patent Laid-Open No. 2003-246709

[0004] The present invention relates to an external skin preparation containing the following components (A), (B), and (C): (A) γ-amino-β-hydroxybutyric acid, (B) one or more osmolytes selected from the group consisting of osmolytes, and (C) water. Detailed Description of the Invention

[0005] γ-amino-β-hydroxybutyric acid has the problem of coloring and odor generation over time, particularly when stored at high temperatures in the presence of water, and also has the problem of sticky feeling during and after application.

[0006] The present inventors have found that by using an osmolyte in combination with γ-amino-β-hydroxybutyric acid, it is possible to obtain an external skin preparation that does not develop odor or coloration even when stored at high temperatures, has excellent storage stability, and does not feel sticky during or after application.

[0007] The topical skin preparation of the present invention has excellent storage stability, does not change in odor or appearance even when stored at high temperatures, and is not sticky or slimy during or after application.

[0008] Component (A), γ-amino-β-hydroxybutyric acid, is a known substance and has the following chemical properties:

[0009]

[0010] From the viewpoint of improving the anti-aging effect on skin and reducing stickiness during and after application, the content of component (A) is preferably 0.001% by mass or more, more preferably 0.005% by mass or more, even more preferably 0.05% by mass or more, even more preferably 0.1% by mass or more, particularly preferably 0.3% by mass or more, preferably 3.5% by mass or less, more preferably 2% by mass or less, even more preferably 1.5% by mass or less, even more preferably 1.2% by mass or less, and particularly preferably 1% by mass or less. The content of component (A) is preferably 0.001% by mass or more and 3.5% by mass or less, more preferably 0.005% by mass or more and 2% by mass or less, even more preferably 0.05% by mass or more and 1.5% by mass or less, even more preferably 0.1% by mass or more and 1.2% by mass or less, and particularly preferably 0.3% by mass or more and 1% by mass or less.

[0011] Component (B) osmolytes are chemical substances that primarily regulate osmotic pressure in living organisms. In cells, they function to maintain cell volume against the influx or excretion of water due to extracellular osmotic stress (osmotic pressure gradient), while also stabilizing the structure and function of proteins such as enzymes over a wide range of concentrations, protecting the proteins from denaturation. Note that component (B) does not include component (D), a pH adjuster, which will be described later. Examples of osmolytes for component (B) include ectoine, sodium pyrrolidone carboxylate (PCA-Na), arginine, arginine hydrochloride, carnitine chloride, taurine, glutamic acid, glutamate, serine, N-methyl-L-serine, trimethylglycine, alanine, and N-amidino-L-proline. From the viewpoint of improving stability during high-temperature storage and reducing stickiness during and after application, the osmolyte preferably contains one or more selected from ectoine, sodium pyrrolidone carboxylate (PCA-Na), arginine, N-methyl-L-serine, trimethylglycine, alanine, and N-amidino-L-proline, and more preferably contains one or more selected from ectoine, sodium pyrrolidone carboxylate (PCA-Na), arginine, N-methyl-L-serine, trimethylglycine, alanine, and N-amidino-L-proline. It is more preferable that the surfactant contains one or more selected from ectoine, sodium pyrrolidone carboxylate (PCA-Na), arginine, trimethylglycine, and N-amidino-L-proline, it is even more preferable that the surfactant contains one or more selected from ectoine, sodium pyrrolidone carboxylate (PCA-Na), trimethylglycine, and N-amidino-L-proline, and it is particularly preferable that the surfactant contains ectoine.

[0012] Component (B) can be used alone or in combination of two or more types, and from the viewpoint of improving stability during high-temperature storage and reducing stickiness during and after application, the content is preferably 0.015% by mass or more, more preferably 0.02% by mass or more, even more preferably 0.3% by mass or more, still more preferably 0.5% by mass or more, particularly preferably 0.8% by mass or more, particularly preferably 0.9% by mass or more, preferably 3.5% by mass or less, more preferably 3% by mass or less, even more preferably 2.5% by mass or less, still more preferably 2% by mass or less, particularly preferably 1.5% by mass or less, particularly preferably 1% by mass or less. Furthermore, the content of component (B) in the total composition is preferably 0.015% by mass or more and 3.5% by mass or less, more preferably 0.02% by mass or more and 3% by mass or less, even more preferably 0.3% by mass or more and 2.5% by mass or less, even more preferably 0.5% by mass or more and 2% by mass or less, particularly preferably 0.8% by mass or more and 1.5% by mass or less, and especially preferably 0.9% by mass or more and 1% by mass or less.

[0013] In the present invention, from the viewpoint of improving stability during high-temperature storage and reducing stickiness during and after application, the molar ratio (B) / (A) of component (B) to component (A) is preferably 0.005 or more, more preferably 0.01 or more, even more preferably 0.1 or more, even more preferably 0.5 or more, particularly preferably 0.75 or more, preferably 5 or less, more preferably 3 or less, even more preferably 2.5 or less, even more preferably 2 or less, and particularly preferably 0.85 or less. Furthermore, the molar ratio (B) / (A) of component (B) to component (A) is preferably 0.005 or more and 5 or less, more preferably 0.01 or more and 3 or less, even more preferably 0.1 or more and 2.5 or less, even more preferably 0.5 or more and 2 or less, and particularly preferably 0.75 or more and 0.85 or less.

[0014] From the viewpoint of uniformly dissolving component (B) and reducing stickiness during and after application, the content of water in component (C) is preferably 20% by mass or more, more preferably 40% by mass or more, and even more preferably 60% by mass or more, and is preferably 99.98% by mass or less, more preferably 90% by mass or less, and even more preferably 85% by mass or less. The content of water in component (C) is preferably 20% by mass or more and 99.98% by mass or less, more preferably 40% by mass or more and 90% by mass or less, and even more preferably 60% by mass or more and 85% by mass or less, based on the total composition.

[0015] The topical skin preparation of the present invention may further contain (D) a pH adjuster, which can improve stability during high-temperature storage. Note that component (D) does not include the osmolyte of component (B). Any pH adjuster commonly used in cosmetics may be used, with inorganic acids and their salts, and organic acids having 6 or fewer carbon atoms and their salts being preferred, and organic acids having 6 or fewer carbon atoms and their salts being more preferred. The inorganic acid preferably contains one or more acids selected from, for example, hydrochloric acid, nitric acid, nitrous acid, sulfuric acid, sulfurous acid, phosphoric acid, phosphonic acid, phosphinic acid, and their salts, and more preferably contains one or more acids selected from phosphoric acid and their salts. Furthermore, the organic acid having 6 or fewer carbon atoms and its salts is preferably a water-soluble organic acid and its salt, such as a fatty acid, hydroxy acid, or dicarboxylic acid having 1 to 6 carbon atoms, and its salts. Among these, it is preferable to include one or more selected from malic acid, lactic acid, citric acid, succinic acid, acetic acid, tartaric acid, aspartic acid, adipic acid, and salts thereof, more preferably one or more selected from malic acid, lactic acid, citric acid, succinic acid, and salts thereof, and even more preferably one or more selected from succinic acid, citric acid, and salts thereof. The pH adjuster is preferably one or more selected from organic acids having 6 or less carbon atoms and salts thereof, more preferably one or more selected from succinic acid, citric acid, and salts thereof.

[0016] Component (D) can be used alone or in combination of two or more, and from the viewpoint of improving stability during high-temperature storage, the content is preferably 0.01% by mass or more, more preferably 0.03% by mass or more, even more preferably 0.05% by mass or more, even more preferably 0.08% by mass or more, and preferably 1% by mass or less, more preferably 0.5% by mass or less, even more preferably 0.3% by mass or less, and even more preferably 0.1% by mass or less, based on the total composition. The content of component (D) is preferably 0.01% by mass or more and 1% by mass or less, more preferably 0.03% by mass or more and 0.5% by mass or less, even more preferably 0.05% by mass or more and 0.3% by mass or less, and even more preferably 0.08% by mass or more and 0.1% by mass or less.

[0017] The topical skin preparation of the present invention may further contain a water-soluble polysaccharide. The water-soluble polysaccharide is not limited as long as it is one that is commonly used in cosmetics, and may be derived from a natural product or obtained by chemical synthesis.

[0018] Also included as polysaccharide-like substances are derivatives of polysaccharides obtained by bonding, to part of the sugar of a polysaccharide, an alkyl group, a hydroxyalkyl group, a polyalkylene oxide group such as a polyethylene oxide group or a polypropylene oxide group, a sugar such as glucose, lactose, or sucrose, or a polymer having these sugars as a constituent unit.

[0019] Specific examples include mucopolysaccharides such as locust bean gum, guar gum, tamarind gum, quince seed-derived gum, gum arabic, tragacanth gum, karaya gum, carrageenan, alginic acid, pectin, hydroxypropyl guar gum, methylcellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, carboxymethylcellulose, tuberose polysaccharide, xanthan gum, Alcaligenes latus-produced polysaccharides, gellan gum, dextran, pullulan, hyaluronic acid or a salt thereof, chondroitin sulfate, dermatan sulfate, chitin, chitosan, etc. Among these, from the viewpoint of improving moisturizing feeling, it is preferable to contain one or more selected from carrageenan, hydroxypropyl methylcellulose, hyaluronic acid or a salt thereof, and it is more preferable to contain at least hyaluronic acid or a salt thereof.

[0020] The water-soluble polysaccharides can be used alone or in combination of two or more, and from the viewpoint of improving the feel when the topical preparation is applied, the content is preferably 0.01% by mass or more in the total composition, more preferably 0.02% by mass or more, even more preferably 0.03% by mass or more, and preferably 1% by mass or less, more preferably 0.5% by mass or less, and even more preferably 0.1% by mass or less.In addition, the content of the water-soluble polysaccharides is preferably 0.01% by mass or more and 1% by mass or less, more preferably 0.02% by mass or more and 0.5% by mass or less, and even more preferably 0.03% by mass or more and 0.1% by mass or less in the total composition.

[0021] The topical skin preparation of the present invention may further contain a polyhydric alcohol. The polyhydric alcohol does not include the osmolyte of component (B). The polyhydric alcohol is a compound having two or more hydroxyl groups in the molecule, and any of those commonly used in topical skin preparations may be used. Examples of dihydric alcohols include polyethylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, polypropylene glycol, 1,3-butylene glycol, and propanediol. Examples of trihydric alcohols include glycerin and trimethylolpropane. Examples of tetrahydric alcohols include diglycerin and erythritol. Examples of pentahydric or higher polyhydric alcohols include polyglycerins such as triglycerin; and sugars and sugar alcohols such as glucose, maltose, maltitol, sucrose, xylitol, sorbitol, malbitol, polyoxyethylene methyl glucoside, polyoxyethylene ethyl glucoside, and polyoxyethylene propylene glucoside.

[0022] From the viewpoint of improving the moisturizing feeling, the polyhydric alcohol preferably contains one or more selected from dihydric alcohols, trihydric alcohols, tetrahydric alcohols, sugars, and sugar alcohols, more preferably contains one or more selected from trihydric alcohols, tetrahydric alcohols, sugars, and sugar alcohols, and even more preferably contains one or more selected from glycerin, diglycerin, sorbitol, and glucose.

[0023] The polyhydric alcohol can be used alone or in combination of two or more, and from the viewpoint of improving the feeling when the topical preparation is applied, the content is preferably 1% by mass or more in the whole composition, more preferably 3% by mass or more, even more preferably 5% by mass or more, preferably 20% by mass or less, more preferably 15% by mass or less, even more preferably 12% by mass or less.The content of water-soluble polysaccharide is preferably 1% by mass or more and 20% by mass or less in the whole composition, more preferably 3% by mass or more and 15% by mass or less, even more preferably 5% by mass or more and 12% by mass or less.

[0024] In addition to the above-mentioned components, the skin external preparation of the present invention can contain the components used in ordinary skin external preparations, such as oily components, surfactants, preservatives, antioxidants, pigments, fragrances, plant extracts, coloring agents, powders, ultraviolet absorbers, moisturizers other than polyhydric alcohols, blood circulation promoters, cooling agents, antiperspirants, bactericides, skin activators, etc. In addition, when containing diisopropylamidinochloroacetic acid, from the viewpoint of improving stability during high-temperature storage and reducing stickiness during and after application, its content is preferably 0.1% by mass or less, more preferably 0.05% by mass or less, even more preferably 0.01% by mass or less, and even more preferably does not contain substantially.In addition, the skin external preparation of the present invention can be used as a hypersensitivity alleviator.

[0025] The topical skin preparation of the present invention can be produced by a conventional method, for example, by adding components (A), (B) and other ingredients to water while stirring, and then stirring.

[0026] From the viewpoint of enhancing transdermal absorbability, the pH of the topical skin preparation of the present invention is preferably 4 to 7, more preferably 4.5 to 6.5, and even more preferably 5 to 6. In the present invention, the pH is measured at 25°C using a tabletop pH meter F-72 manufactured by HORIBA.

[0027] The topical skin preparation of the present invention can be applied to cosmetics, medicated cosmetics that are quasi-drugs, pharmaceuticals, etc. It is suitable as a cosmetic, more preferably as a skin care cosmetic such as a skin care lotion, a skin care emulsion, a skin care cream, a BB cream, or a beauty serum, and even more preferably as a skin care lotion.

[0028] In relation to the above-described embodiment, the present invention further discloses the following composition. <1> A topical skin preparation containing the following components (A), (B), and (C): (A) γ-amino-β-hydroxybutyric acid, (B) one or more osmolytes selected from the group consisting of osmolytes, and (C) water. <2> The topical skin preparation according to <1>, wherein the content of component (A) is preferably 0.001% by mass or more and 3.5% by mass or less, more preferably 0.005% by mass or more and 2% by mass or less, even more preferably 0.05% by mass or more and 1.5% by mass or less, still more preferably 0.1% by mass or more and 1.2% by mass or less, and especially preferably 0.3% by mass or more and 1% by mass or less, based on the total composition. <3> The topical skin preparation according to <1> or <2>, wherein component (B) preferably contains one or more selected from ectoine, sodium pyrrolidone carboxylate (PCA-Na), arginine, N-methyl-L-serine, trimethylglycine, alanine, and N-amidino-L-proline, more preferably one or more selected from ectoine, sodium pyrrolidone carboxylate (PCA-Na), arginine, N-methyl-L-serine, trimethylglycine, and N-amidino-L-proline, even more preferably one or more selected from ectoine, sodium pyrrolidone carboxylate (PCA-Na), arginine, trimethylglycine, and N-amidino-L-proline, still more preferably one or more selected from ectoine, sodium pyrrolidone carboxylate (PCA-Na), trimethylglycine, and N-amidino-L-proline, and particularly preferably ectoine. <4> The topical skin preparation according to any one of <1> to <3>, wherein the content of component (B) in the total composition is preferably 0.015% by mass or more and 3.5% by mass or less, more preferably 0.02% by mass or more and 3% by mass or less, even more preferably 0.3% by mass or more and 2.5% by mass or less, still more preferably 0.5% by mass or more and 2% by mass or less, particularly preferably 0.8% by mass or more and 1.5% by mass or less, and particularly preferably 0.9% by mass or more and 1% by mass or less.<5> The topical skin preparation according to any one of <1> to <4>, wherein the molar ratio (B) / (A) of component (B) to component (A) is preferably 0.005 to 5, more preferably 0.01 to 3, even more preferably 0.1 to 2.5, even more preferably 0.5 to 2, and particularly preferably 0.75 to 0.85. <6> The topical skin preparation according to any one of <1> to <5>, wherein the content of component (C) is preferably 20% to 99.98% by mass, more preferably 40% to 90% by mass, and even more preferably 60% to 85% by mass, of the total composition. <7> The topical skin preparation contains the following components (A), (B), and (C): (A) 0.3% to 3.5% by mass of γ-amino-β-hydroxybutyric acid, (B) one or more osmolytes, and (C) water. <8> A topical skin preparation containing the following ingredients (A), (B), and (C): (A) 0.3% by mass or more and 3.5% by mass or less of gamma-amino-beta-hydroxybutyric acid, (B) one or more selected from ectoine, sodium pyrrolidonecarboxylate, arginine, trimethylglycine, N-methyl-L-serine, and N-amidino-L-proline, and (C) water. <9> The topical skin preparation according to <7> or <8>, wherein the content of ingredient (B) is 0.015% by mass or more and 3.5% by mass or less of the total composition. <10> A topical skin preparation containing the following ingredients (A), (B), and (C): (A) gamma-amino-beta-hydroxybutyric acid, (B) one or more selected from ectoine, sodium pyrrolidonecarboxylate, arginine, trimethylglycine, and N-amidino-L-proline, and (C) water. <11> A topical skin preparation containing the following components (A), (B), and (C): (A) γ-amino-β-hydroxybutyric acid, (B) ectoine, and (C) water. <12> The topical skin preparation according to <10> or <11>, wherein the content of component (A) is from 0.001% by mass to 3.5% by mass of the total composition, and the content of component (B) is from 0.015% by mass to 3.5% by mass of the total composition. <13> The topical skin preparation according to any one of <1> to <10>, further comprising (D) one or more selected from a pH adjuster, a water-soluble polysaccharide, and a polyhydric alcohol.

[0029] Examples 1 to 20, Comparative Example 1 External skin preparations (lotions) were prepared with the compositions shown in Tables 1 and 2, and the pH was measured. The odor after storage at 50°C for one month, the appearance after storage at 50°C for one month, and the lack of stickiness during and after application were evaluated. The results are also shown in Table 1. In Table 1, PCA-Na refers to sodium pyrrolidone carboxylate.

[0030] (Production Method) Components (A), (B) and other ingredients were added to water at 25°C while stirring, and the mixture was stirred to produce an external skin preparation (lotion).

[0031] (Evaluation Methods) (1) pH: Immediately after production, the pH of each topical skin preparation was measured at 25° C. using a tabletop pH meter F-72 manufactured by HORIBA.

[0032] (2) Odor after storage at 50°C for 1 month: 40 g of each topical skin preparation was filled into a 50 mL glass bottle and stored in a thermostatic chamber at 50°C for 1 month. After storage, the glass bottle containing the topical skin preparation was removed from the thermostatic chamber at 50°C and allowed to stand at 25°C for 6 hours. The lid of the glass bottle was then opened, and the odor of the topical skin preparation was subjected to a sensory evaluation based on the following criteria: A: Only the odor of the original base material was detected. B: A weak strange odor was detected. C: A clear strange odor was detected.

[0033] (3) Appearance after storage at 50°C for 1 month: 40 g of each topical skin preparation was filled into a 50 mL glass bottle and stored in a thermostatic bath at 50°C for 1 month. After storage, the glass bottle containing the topical skin preparation was removed from the thermostatic bath at 50°C and allowed to stand at 25°C for 6 hours. Thereafter, the appearance of the cosmetic was observed with the naked eye and evaluated according to the following criteria. A: Colorless and transparent. B: Weak coloring was observed. C: Clear coloring was observed.

[0034] (4) Non-stickiness during and after application: Ten expert panelists took approximately 0.2 g of each skin cosmetic on the back of their hand and applied it with their fingers, and evaluated the non-stickiness during and after application according to the following criteria. The results were shown as the total score of the 10 panelists: 3 points: No stickiness felt; 2 points: Mild stickiness felt; 1 point: Strong stickiness felt.

[0035]

[0036]

[0037] Formulation Example 1 (Lotion) (Ingredients) 1. γ-amino-β-hydroxybutyric acid 0.3 (mass%) 2. Allantoin 0.5 3. Citric acid appropriate amount (0.01 to 0.2) 4. Succinic acid appropriate amount (0.01 to 0.2) 5. Trisodium citrate appropriate amount (0.01 to 0.2) 6. Glycerin 5.0 7. Diglycerin 2.0 8. Sodium hyaluronate 0.1 9. Carrageenan 0.15 10. Ectoin 0.7 11. N-methyl-L-serine 0.1 12. Sodium benzoate 0.21 3. Water balance Total 100

[0038] (Production Method) While stirring, ingredients 1 to 12 are added in order and dissolved in water, and the resulting mixture is filtered to produce a lotion (pH 4 to 7).

[0039] Formulation Example 2 (Serum) (Ingredients) 1. Ascorbic acid 2-glucoside 3.0 (mass%) 2. γ-amino-β-hydroxybutyric acid 1.5 3. Citric acid appropriate amount (0.01 to 0.2) 4. Trisodium citrate appropriate amount (0.01 to 0.2) 5. Potassium hydroxide appropriate amount (0.1 to 1.0) 6. Glycerin 3.0 7. Diglycerin 1.0 8. 1,3-butylene glycol 5.0 9. Carboxyvinyl polymer appropriate amount (0.1 to 1.0) 10. Sodium hyaluronate 0.05 11. Alanine 0.5 12. Ectoine 0.05 13. Arginine appropriate amount (0.1 to 1.0) 14. Phenoxyethanol 0.3 15. Polyoxyethylene hydrogenated castor oil (60E.O.) 0.2 16. Fragrance (as needed) 17. Water (remaining) Total 100

[0040] (Production Method) Components 1 to 13 are added in order while stirring the water and dissolved, and 15 and 16 are separately mixed and then added to the pre-mixed aqueous phase to produce a cosmetic serum (pH 6-7). The amount of component 9 is adjusted so that the final viscosity of the cosmetic serum is 1,000-20,000 mPa s as measured with a Brookfield viscometer at 30°C.

[0041] Formulation Example 3 (Emulsion) (Ingredients) 1. γ-amino-β-hydroxybutyric acid 0.2 (mass%) 2. Nicotinamide 1.0 3. Citric acid Appropriate amount (0.01 to 0.2) 4. Trisodium citrate Appropriate amount (0.01 to 0.2) 5. Glycerin 5.0 6. Carrageenan 0.2 7. N-methyl-L-serine 0.2 8. Trimethylglycine 0.3 9. Water Remaining 10. Hydrogenated soybean phospholipid (PC content 50 to 95%) 0.5 11. Cholesterol (phytosterol) 0.5 12. Sugar squalane 8.0 13. Polyglyceryl-10 diisostearate 1.0 14. Octyldodecyl myristate 3.0 15. 16. Isostearic acid 0.5 17. Dipropylene glycol 5.0 18. 1,3-butylene glycol 3.0 19. Fragrance appropriate amount (0-0.5) 20. Phenoxyethanol 0.5 21. Carboxyvinyl polymer appropriate amount (0.1-1.0) 22. Potassium hydroxide appropriate amount Total 100

[0042] (Production Method) Components 1 to 9 are dissolved with stirring at 80°C, gradually added to components 10 to 19 previously dissolved at 80°C, dispersed and emulsified using a homomixer (HM), and then cooled. Components 20 to 22 are added sequentially at around 50°C, dispersed again using the HM, and cooled to 30°C to produce an emulsion. (pH 5 to 7) The amount of component 21 is adjusted so that the final viscosity of the emulsion, measured using a Brookfield viscometer at 30°C, is 1,500 to 20,000 mPa s.

[0043] Formulation Example 4 (Cream) (Ingredients) 1. γ-amino-β-hydroxybutyric acid 2.0 (mass%) 2. Citric acid Appropriate amount (0.01 to 0.2) 3. Trisodium citrate Appropriate amount (0.01 to 0.2) 4. Phytic acid 0.1 5. Sodium benzoate 0.2 6. Dipotassium glycyrrhizinate 0.1 7. Glycerin 5.0 8. Maltitol 8.0 9. Sodium hyaluronate 0.1 10. PCA-Na 1.0 11. Ectoin 0.5 12. Water (remaining) 13. Hydrogenated soybean phospholipid 1.0 14. Cholesterol (phytosterol) 0.5 15. Palmitic acid 0.2 16. Behenyl alcohol 1.0 17. Vegetable squalane 10.0 18. Isostearic acid 0.5 19. Cetyl alcohol 0.5 20. Macadamia nut oil 3.0 21. Jojoba oil 3.0 22. Dipropylene glycol 5.0 23. 1,3-butylene glycol 3.0 24. Fragrance appropriate amount (0-0.5) 25. Carboxyvinyl polymer appropriate amount (0.1-1.0) 26. Potassium hydroxide appropriate amount Total 100

[0044] (Manufacturing Method) Components 1 to 12 are dissolved by stirring at 80°C, gradually added to components 13 to 24 previously dissolved at 80°C, dispersed and emulsified using a homomixer (HM), and then cooled. Components 25 and 26 are added sequentially at around 50°C, dispersed again using the HM, and cooled to 30°C to produce a cream. (pH 5 to 7) The amount of component 25 is adjusted so that the final viscosity of the cream, measured with a Brookfield viscometer at 30°C, is 10,000 to 300,000 mPa s.

[0045] All of the external skin preparations of Formulation Examples 1 to 4 do not produce odor or coloration even when stored at high temperatures, have excellent storage stability, and do not feel sticky during or after application.

Claims

1. A topical skin preparation containing the following components (A), (B) and (C): (A) γ-amino-β-hydroxybutyric acid, (B) one or more selected from osmolytes, (C) water.

2. The topical skin preparation according to claim 1, wherein the component (B) is one or more selected from ectoine, sodium pyrrolidone carboxylate, arginine, arginine hydrochloride, carnitine chloride, taurine, glutamic acid, glutamate, serine, N-methyl-L-serine, trimethylglycine, alanine.

3. The topical skin preparation according to claim 1 or 2, wherein the molar ratio (B) / (A) of the component (B) to the component (A) is 0.005 to 5.

4. The topical skin preparation according to any one of claims 1 to 3, wherein the content of the component (A) is 0.001 to 3.5% by mass.

5. The topical skin preparation according to any one of claims 1 to 4, wherein the content of the component (B) is 0.015 to 3.5% by mass.

6. The topical skin preparation according to any one of claims 1 to 5, further containing (D) a pH adjuster.

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