Device for boosting normal cell vitality using electric fields

Abstract

The present invention discloses an electric field generating device (20) for boosting normal cell vitality comprising an electric field generator (101) used for outputting electric field stimulation, an end of cables (102) connected at one end to the electric field generator (101), and at another end to a controller (104), then further connected to a plurality of electric conductive plates (103). Then, the electric conductive plates (103) are a capacitance-based electrode configuration, with an electrode panel (105) designed to encase a plurality of movable electric conductive plates (103a) and are extendable to suit the user's body condition. The controller (104) is a multimode controller that controls electric field signal modes to target different organs needs, and an outlet (106) to encase a plurality of the electric conductive plates (103); the electrode panel (105); and the controller (104) in a convertible design. The electric conductive plates (103) comprise the movable electric conductive plates (103a), a fixed electric conductive plates (103b), or a combination thereof.

Description

[0001] DEVICE FOR BOOSTING NORMAL CELL VITALITY USING ELECTRIC FIELDS

[0002] FIELD OF INVENTION

[0003] The present invention comprehensively relates to an electric field-generating device for boosting normal cell vitality.

[0004] BACKGROUND OF THE INVENTION

[0005] The electric field device designed to boost normal cell vitality utilises electric fields to stimulate cell growth and function within the body. Electric field serves as stimulants capable of exerting force on charged particles (i.e. electrons and ions). They have the potential to influence various aspects of cell behaviour, movement, shape, polarity, division, and cellular communication. Examples of electric fields with the capacity to enhance cell vitality include both endogenous electric fields and exogenous electric fields.

[0006] Endogenous electric fields refer to the natural electric field inherent in the body, found in areas such as the brain, heart, and muscles. These electric fields play a crucial role in modulating the activity of neurons, cardiac cells, and muscle cells. The significance of the endogenous electric field is evident in processes such as wound healing, tissue development, and nerve regeneration. Conversely, exogenous electric fields are artificial electric fields applied externally to the body, utilizing methods like electrodes or implants. These external electric fields are employed for the treatment of various diseases and disorders by influencing cellular functions. Their applications include enhancing tissue regeneration, improving blood circulation, reducing inflammation, and stimulating nerve regeneration.

[0007] Normal cells are essential components of the body, adhering to regulated growth, contact inhibition, and differentiation processes. They exhibit responsiveness to signals, undergo apoptosis for controlled cell death, and maintain genetic stability through DNA repair mechanisms. Adhering to tissue architecture, normal cells contribute to organized structures within organs. With a limited lifespan, some cells are consistently replaced, while others endure throughout life. Specialized for specific functions, normal cells collaboratively ensure the health and proper functioning of tissues and organs. A comprehension of these characteristics is imperative for studying health, disease, and potential therapeutic interventions, underscoring the significance of normal cellular processes in maintaining overall bodily well-being.

[0008] Normal cells may undergo improved membrane permeability, enhanced nutrient uptake, and optimized cellular functions when exposed to electric field stimulation. This non-invasive therapy exhibits potential to promote cell regeneration and support metabolic processes, thereby enhancing overall vitality. Electric field stimulation has the capacity to influence and enhance cellular communication and signalling pathways, thereby contributing to the maintenance of a healthy cellular environment. The controlled administration of electric fields may assist in restoring cellular balance, potentially benefiting tissues and organs.

[0009] In the context of revolutionizing therapy development, the integration of electric field applications in cell therapy is crucial. Electric fields can stimulate cell's behaviour and function, thereby enhancing and promoting cell vitality, enabling the cells to survive, grow, and perform their functions. The utilisation of electric fields in cell therapy offers a non-penetrative and non-invasive method which does not necessitate the insertion of any devices and / or substances into the body. This renders electric field cell treatment a superior alternative to conventional cell therapy methods, which may involve injections, surgeries, and transplantation procedures. Furthermore, electric field therapy facilitates the repair and replacement of damaged cells, tissues, and organs, providing a beneficial approach for various applications in the treatment of diverse diseases and conditions.

[0010] A device of the present invention utilises exogenous electric field applications to boost normal cell vitality. The device comprises one or more electrodes that are embedded in the device. These electrodes are designed to generate an exogenous electric field that can match tissue and organ’s endogenous electric field. The exogenous electric field may be adjusted to have different frequencies, amplitudes, durations, or polarities depending on the desired effect on the cells.

[0011] The electric field therapy is applicable for providing therapy to various body systems, including but not limited to the skeletal system, endocrine system, cardiovascular system, lymphatic system, digestive system, urinary system, and reproductive system, along with their respective normal cell vitality, ensuring comprehensive treatment for each body system and its associated normal cell health.

[0012] The electric field can provide a therapeutic effect to the cells from these systems including but not limited to: i. Skeletal system: includes organs such as bone and connective tissues (i.e. cartilages, tendons, and ligaments). This system includes the inflammatory cells, nucleus pulposus cells, annulus fibrosus cells, chondrocytes, and fibrochondrocytes. ii. Cardiovascular or circulatory system: includes organs such as the heart and blood vessels. This system includes red blood cells (RBCs), white blood cells (WBCs), hematopoietic stem cells, plasma, and platelets. The hematopoietic stem cells are the multipotent cells that give rise to all blood cell types. The electric field stimulation can improve blood count, such as RBC and WBC, and platelets, by improving hematopoiesis modulation and the blood cell formation process. iii. Lymphatic system: includes organs such as bone marrow, thymus, lymph nodes, spleen, tonsil, and mucous membrane. The spleen consists of lymphocytes, macrophages, dendritic cells, white pulp cells, and red pulp cells. iv. Endocrine system: includes organs such as the hypothalamus, pineal body, pituitary, thyroid, thymus, adrenal gland, pancreas, ovary or testis. The adrenal gland includes the chromaffin cells. v. Digestive system: includes organs such as salivary glands, pancreas, liver, gall bladder, esophagus, stomach, small and large intestines, and anus. The cells involved in this system include the hepatocytes, Kupffer cells, endothelial cells, stellate cells, and lymphocytes which are associated with the liver, Meanwhile, the islets of Langerhans in the pancreas include the alpha cells, beta cells, delta cells, pancreatic polypeptides cell, acinar cells, and duct cells. vi. Renal system: includes organs such as the kidney, ureter, urinary bladder, urethra, and renal pelvis. The cells involved in this system are the renal tubular epithelial cells, glomerular mesangial cells, endothelial cells, podocytes, duct cells, and the renal interstitial cells. vii. Reproductive system: includes organs such as fallopian tubes, vagina, uterus, ovaries for females, and penis, testis, and scrotum for males. The cells that are involved in the female reproductive organs are oocyte and follicular cells, granulosa cells, and corpus luteum cells. Meanwhile, male reproductive organs, include Sertoli cells, Leydig cells, and spermatogonia cells.

[0013] Based on Homami, E., Goliaei, B., Shariatpanahi, S. P., and Habibi-Kelishomi, A. 2023. Alternating electric fields can improve chemotherapy treatment efficacy in blood cancer cell U937 (non-adherent cells). BMC Cancer 23: 1 -13, electric fieldbased therapy can be alternated with chemotherapy in order to enhance the chemotherapy drug efficacy. This allows a significant reduction in cancer cell proliferation, inducing apoptosis, and DNA damage in cancer cells. The advantage of using electric field as an alternative therapy is that electric field does not have adverse effect on normal cell proliferation and membrane permeability.

[0014] According to another study by Kolosnjaj-Tabi, J., Gibot, L., Fourquaux, I., Golzio, M., and Rols, M. 2018. Electric field-responsive nanoparticles and electric fields: Physical, chemical, biological mechanisms and therapeutic prospects. Advanced Drug Delivery Reviews 138: 56-67, pulsed electric field therapy, such as irreversible electroporation (IRE), has been proven to induce cell death in large vessels without causing harmful effects to the treated vessels. This shows that IRE can be a safe treatment alternative for non-drug treatment in cancer therapy. Along with that, IRE can induce and enhance cell's immune response compared to conventional treatments such as surgery.

[0015] It is known that conventional cancer therapy such as chemotherapy and radiation therapy does not discriminate between cancerous and normal cells. This results in the deterioration of normal cells during the administration of the treatments. To overcome this problem, electric field treatment has shown potential to promote cell alignment, and viability, thus enhancing tissue regeneration by stimulating extracellular matrix component production. Current development has led to the invention to fine-tune electric field characteristics to be more targeted toward cellular activities.

[0016] A prior US patent US2012016446A1 discloses electric therapeutic clothing that can apply direct current, pulsed direct current, or alternating current electricity of various voltage and current levels, administered to the skin comfortably and conveniently. The prior art also comprises an electronic controller for amplitude adjustment and time programming, transcutaneous electrodes, power source and wiring, percutaneous electrodes, power sources and wiring, and subcutaneously implanted electrodes for wireless electrical transfer, power source, and biocompatible wiring, bio-electrolyte fuel cell power source, remote controller that is wireless and an LED indicator light and / or biography. In the invention, the electrode is located either embedded or woven together within the clothing forming a non-adhesive, nonoxidising, electric conductor (such as conductive plastic and woven fibres) conductive pads. Wires are imbedded in the body suit and a power-circuit module is placed on the belt. The clothing device uses non-invasive, copper-based material, direct current (DC), pulsed DC current, or an alternating current (AC) from a self- powered power source with conductive electrodes. The device utilised electric current in microamperes known as micro-current in the range of 1 pA and 1000 pA, and the interference pattern is formed by various waves of different wavelengths. This invention improves health by providing continuous, healthy antioxidant protection to the human body, increasing percutaneous and transcutaneous current flow across the skin surface during exercise or exertion, helping prevent disease, debilitation, decrease in immune system performance, aiding the immune system in fighting free radicals by providing antioxidant electrons to the skin, enhancing body performance and endurance related to energy and vitality, aiding and helping treat conditions and diseases, improving health and wellness, as well as improving lifespan and longevity. The reduction of free radicals in the body can be an anti- ageing benefit, and the efficacy of the present invention is verified with the periodic application and testing methods available to medical professionals for assaying the levels of free radicals in the blood. The therapeutic electric clothing can increase carotenoid levels after a period of application of electric antioxidants, which certifies the proper operation of this novel clothing device. However, the invention does not disclose utilising a frequency range of 5Hz to 1 MHz and capacitors such as parallel capacitors, cylindrical capacitors, spherical capacitors, variable capacitors, multilayered ceramic capacitors, and film capacitors.

[0017] Another prior art CN108042914A discloses a wearable and non-invasive, electric stimulating instrument in circular, T-shaped, L-shaped, or linear form. The device includes an upper shell, a lower shell, a control device, a power supply device, a stabilizing electrode sheet, an excitatory electrode sheet, and a wireless communication module. The device is made from transparent PC and ABS. The device generates pulse signals depending on the selected mode signal and output current gear signal. The pulse frequency mode, waveform, and amplitude parameter can be predetermined and sent as inputs to its respective receivers which are the pulse-signal generation module, and voltage control module respectively. The invention uses 0-15 V voltage and frequency between 1 -600Hz. The functions of the device include improving the quality of life for people who suffer from sleep disorders or work-related stress and enhancing nervous excitation, which can help alleviate symptoms of anxiety, depression, and agitation. However, the invention does not mention the type of material or metals used and also type of capacitors used.

[0018] Another prior art, US 9072891 B1 , discloses a wearable head stimulator invention that is hands-free, allowing the wearer to go through daily activities without restriction. The device can be worn while sitting, standing, or walking. The device does not require heavy pulse generator and operates on small currents. As the current required is small, the wearable head device does not overheat. The device comprises a body that holds a rechargeable internal power supply, a communication unit to receive electrical stimulation information, a storage unit connected with a communication unit to store electrical stimulation information, a pulse generator, and a magnetic conductor to attract and conduct magnetically the solid circuit, connecting the pulse generator and a control unit. The solid magnetic conductor is for magnetically attracting and conducting the solid magnetic conductor circuit, connecting the stimulating current amplifying unit. The smallgapped head around the neck is close to the body part and carries the stimulator controller. An iron-cored electromagnet has a small air gap; the faces forming the gap have opposite polarity. The face that spills out flux becomes a North Pole while the opposite surface that receives flux becomes a South Pole. Each Pole has a pole face that is perpendicular to the gap and two reluctance faces that are parallel to the gap. Most of the flux, termed main flux flows from the North Pole face to the South Pole face through the small air gap. The device design allows the wearer to self-administer the device to treat a variety of diseases such as erectile dysfunction, depression, migraine headache, incontinence, knee injury, etc. Although the invention is associated with electromagnetic fields, whereas the present invention utilises electric fields, and the invention does not disclose the wearable device material, the electrode arrangement, voltage, the waveform, and the type of capacitors used in the wearable device (i.e. parallel, cylindrical, spherical, variable, multi ceramic, or film).

[0019] Similar to a prior art CN 110721403A that discloses an intermediate-frequency electrical stimulation wearable terminal and an intermediate-frequency electrical stimulation wearable system. The invention uses magnetism to improve body parts' function using a wearable that sticks to the skin using magnetic suction. The invention comprises a main body and a magnetic body connected to the main body where the magnetic body contains a neodymium iron boron solid magnetic conductor. The suction electrode pad, the body and the electrode pad are combined by magnetic suction, allowing the electrode pad to adhere to the skin to deliver intermediate-frequency electrical stimulation. The invention operates with a host where software is embedded and can control the host’s work and communicate with the host computer in low range frequency (<1000 Hz), intermediate rage frequency (1000 Hz-100 kHz), and high range frequency (> 100 kHz). The invention also comprises a complementary output generator (COG), a capture I compare I PWM Module (Capture I Compare I PWM, CCP) and a digital- to-analog converter (DAC). The main control unit can control the voltage amplitude accurately. The invention also comprises a numerical control oscillator (Numerically Controlled Oscillator, NCO), the waveform generator (Complementary Waveform Generator, CWG) and the digital-to-analog converter (Digital-to-Analog Converter, DAC). In contrast to the present invention, the invention also does not disclose the wearable material, the electrode arrangement, voltage, the waveform, and the type of capacitors used in the wearable device (i.e. parallel, cylindrical, spherical, variable, multi ceramic, or film).

[0020] A prior art from Japan (JP H04141180 A), on the other hand, discloses an efficient electrotherapy apparatus fitted to a patient and to use the device without any adverse reaction to the patient anxiety through an output means for outputting signal output by converting means of a pair of electrodes. The specific signal is set to a cellular activity signal at the desired human body part. The signal applied to the electrode pair has a waveform and an electric potential inherent to human cells. The waveform can be rectangular wave, stinging wave, sine wave, half wave, triangular wave, or exponential wave. The waveform is used to treat affected human body parts by electrical stimulation. The invention however does not disclose the embodiment either in a wearable, frame, or chamber form and, therefore does not anticipate the present invention features.

[0021] Meanwhile, patents CA 2640134 A1 , CN 111481823 A, and US 7565205 B2 each disclose a wearable device that utilised an electric field which is similar to the present invention. Even so, these inventions are applied in tumour tissue treatment and use different dielectric requirements compared to the present invention, which focuses on enhancing normal and healthy cell vitality. Nonetheless, these inventions disclose the use of storage capacitors in patent CA 2640134 A1 and capacitor electrode arrangement in CN 111481823 A and US 7565205 B2 which use parallel electrodes and array electrodes, respectively.

[0022] The need for a device to provide electric field based stimulation to enhance cell vitality without the usage of invasive features. Hence the present invention is deemed to be new and obvious as it utilises electric field to boost normal cell vitality in a flexible and adjustable means.

[0023] SUMMARY OF THE PRESENT INVENTION

[0024] The present invention introduces a device, for generating electric field to boost normal cell vitality for use in a variety of therapeutic applications, including but not limited to antiaging skincare devices, pharmaceuticals, medical devices, cancer treatment, neuroscience, biotechnology, agriculture, cosmeceuticals, and wellness devices. The objective may be achieved by following the teaching of the present invention, which pertains to an electric field generating device for boosting normal cell vitality. The device comprises an electric field generator for outputting electric field stimulation and cables that connect the electric field generator to other parts of the device, with one end connected to the generator and another end connected to a controller. The controller is further connected to a plurality of electric conductive plates, a multimode controller capable of adjusting and controlling electric field signal modes to suit different organs or body system’s needs, electric conductive plates utilising a capacitance-based electrode configuration, an electrode panel designed to encase the movable electric conductive plate and is movable and adjustable to suit user’s body condition, and an outlet designed to encase a plurality of the electric conductive plates, the electrode panel, and the controller in a convertible design. Additionally, the waveforms can be characterized in the range of -60 V to +60 V (peak-to-peak voltage of 120 V) and the electric conductive plates comprises the movable electric conductive plates, a fixed electric conductive plates, or a combination thereof. Controlled electric field stimulation can stimulate normal cellular processes, promoting growth, tissue repair, and overall vitality. Targeting normal cells is essential for supporting tissue health, optimizing cellular communication, and regulating inflammatory responses. In situations where specific abnormal cells are targeted, efforts are made to minimize unintended effects on adjacent normal cells. Hence, electric field therapy has the potential to contribute to regenerative processes, encouraging repair and renewal of the normal cells in the body systems.

[0025] Preferably, the device utilises non-penetrative electrodes for non-invasive treatment, enabling therapy administration without the necessity for surgical procedures or skin puncturing. This reduces infection risk and discomfort, particularly during prolonged or repeated therapy sessions.

[0026] Preferably, the electric conductive plate adopts a capacitance-based electrode configuration, which can assume certain shapes or arrangements affecting its capacitance. These may include, but are not limited to, parallel capacitors; cylindrical capacitors; spherical capacitors; variable capacitors; multi-layered ceramic capacitors; film capacitors; or a combination thereof, each with distinct characteristics such as size, shape, material, voltage, frequency, and temperature.

[0027] Preferably the electrode panel is retractable and detachable to accommodate diverse sizes and shapes. The retractability and detachability offer users’ flexibility, allowing easy attachment or removal of the device, enhancing the convenience of use and reducing the risk of damage or contamination to the electrode panel.

[0028] Preferably, the controller is adjustable to variable modes for different organ or body system needs, enabling it to modify the electric field signal to suit various types of tissue, organs, and body systems. This provides versatility to the device, enhancing its effectiveness as different tissues, organs, and body systems may exhibit diverse responses to the electric field stimulation. The controller can be wired or wireless, or a combination thereof, indicating that it can be connected to the device or the power source through wires and / or wireless connection, or both, allowing the device to be portable and user-friendly. Preferably, the electric field is generated through direct current (DC); alternating current (AC); pulse generator; high frequency; low frequency; neutral stimulation; or a combination thereof.

[0029] Preferably, the electric conductive plate is a fixed and / or movable electric conductive plate, equipped with positive and negative electrodes which are also capable of acting as adaptive electrodes and connected to a multimode controller. In a fixed position, the electric conductive plate can deliver stable and consistent electric field stimulation, while the movable electric conductive plates allow greater flexibility and convenience in adjusting the position and orientation of the electric field stimulation. The electric conductive plates, fitted with positive and negative electrodes, generate the electric field due to the potential difference between the positive and negative electrodes. Connecting the electric conductive plates to the multimode controller enables control over the intensity, duration, and mode of the electric field stimulation.

[0030] Preferably, the electric conductive plates are foldable panels with ventilation airways, extendable, and flexible. The advantages of these characteristics in the present invention are as follows: i. Foldability: Enables the device to be compact and portable, adaptable to different surfaces and geometries. ii. Ventilation airways: Facilitate airflow, providing comfort and breathability, and preventing overheating and heat accumulation. iii. Extendibility: Enhances versatility and efficiency in covering larger regions and volumes. iv. Flexibility: Ensures durability and resilience, by allowing the plates to conform to different curvatures and angles.

[0031] The present invention consists of features and a combination of parts hereinafter fully described and illustrated in the accompanying drawings, it being understood that various changes in the details may be made without departing from the scope of the invention or sacrificing any of the advantages of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0032] To further clarify various aspects of some embodiments of the present invention, a more particular description of the invention will be rendered by reference to specific embodiments thereof, which are illustrated in the appended drawings. It is appreciated that these drawings depict only typical embodiments of the invention and are therefore not to be considered limiting of its scope. The present invention will be described and explained with additional specificity and detail through the accompanying drawings in which:

[0033] Figure 1 is an illustration showing the connection setup of the main electric conductive plate design where 102a, 102b, 102c, and 102d indicate the cables connected to specific electric conductive plates, each directed to plates designed for a particular organ or body system.

[0034] Figure 2 is an illustration showing the outlet in wearable attire designs where Figure 2.1 depict a wearable vest with (a) the front view, (b) the back view, and (c) the side view of the wearable vest. Figure 2. II depicts a wearable belt with (a) an angle view of the belt, and (b) a side view of the belt.

[0035] Figure 3 is an illustration showing the outlet in a chair or seating configuration design where (a) is the side view and (b) is the top view of the chair or seating design with a retractable electrode panel.

[0036] Figure 4 is an illustration showing the outlet in chamber design for full body therapy where (a) is the top view of the chamber, (b) is the side view of the chamber illustrating the movable electric conductive plate, and (c) is the side view of the chamber illustrating the chamber foldability and compact design for storage. Reference

[0037] Numerals Description

[0038] 20 Electric field generating device

[0039] 101 Electric field generator

[0040] 102 Cable

[0041] 103 Electric conductive plates

[0042] 103a Moveable electric conductive plates

[0043] 103b Fixed electric conductive plates

[0044] 104 Controller

[0045] 105 Electrode panel

[0046] 106 Outlet

[0047] DETAILED DESCRIPTION OF THE INVENTION

[0048] In the following detailed description, numerous specific details are outlined in order to provide a thorough understanding of the invention. However, it will be understood by those skilled in the art that present invention may be practised without these specific details. In other instances, well-known methods, procedures, and components have not been described in detail so as not to obscure the present invention.

[0049] The general principles of the present invention relate to the development of an integrated, portable, non-penetrative electric field generating device for boosting normal cell vitality. In particular, the present invention explores the dual potential of electric fields, with a broad spectrum of applications, making it applicable for localized concerns and overall cellular heath maintenance. This includes but is not limited to, enhancing cellular nutrition and facilitating the delivery of therapeutic drugs and chemical delivery to specific cellular targets. The improvement in nutrient uptake and drug or chemical delivery mechanisms contributes to promoting comprehensive cellular health. Additionally, the present invention describes a teaching capable of performing target-specific and / or also full body treatment through electric field stimulation to address cell deterioration due to the ageing process and / or after cancer treatment (i.e. chemotherapy and radiation therapy).

[0050] The present invention is characterised as an integrated, portable, and non- penetrative device, offering versatility and ease of use with the ability to adjust according to various settings and user needs. The utilisation of non-penetrative electrodes can eliminate or reduce infection risk and discomfort to the user especially during long-term or repeated therapy sessions, as they can be applied to the body without piercing or penetrating the skin. This also facilitates device applications, making them more accessible to users. The non-penetrative electrodes enable targeted treatment by being placed on the body to target specific areas, allowing localised therapy and concentrating the therapeutic effects on the desired region without affecting surrounding cells.

[0051] Specifically, the electric field generating device (20) comprises 4 main components: an electric field generator (101 ) to generate electric stimulation, an electric conductive plate (103) with ventilation airways to allow aeration, a controller (104) to control the electric field stimulation modes, an electrode panel (105) comprising moveable electric conductive plate (103a) to provide coverage in the therapy area, and outlet (106) which is configured into a plurality of design to suit user preferences and treatment therapy. The components of the present invention can be described as follows: i. an electric field generator (101 ): for outputting electric field stimulation generated from various power sources (i.e. DC, AC, pulse generator, high and low frequencies, neutral stimulation, or a combination thereof) which is a form of physical energy that can affect cellular bioelectricity that is crucial for cellular migration, proliferation, and differentiation. ii. cables (102): connective wires that connect the electric field generator (101 ) to the other parts of the device in a way where one end is connected to the generator, and another end is connected to a controller (104) which is further connected to a plurality of electric conductive plates (103). iii. electric conductive plates (103): parts acting as electrodes and are capacitance-based electrodes with the ability to store electric charge, creating a capacitive coupling with tissue to allow the electric field to pass through the tissues without direct contact. iv. a controller (104): connected to the plurality of electric conductive plates (103) to deliver and regulate the electric stimulation, controlling the intensity, frequency, duration, and mode of the electric field. The controller (104) is a multimode controller capable of adjusting and controlling electric field signal modes to suit different organs or body system’s needs. v. an electrode panel (105): a component of the device designed to encase the movable electric conductive plate (103a) and is movable and adjustable to suit the user's body condition. The electrode panel (105) is extendable and retractable to fit different sizes and shapes of the user. vi. an outlet (106): designed to contain a plurality of the electric conductive plates (103), the electrode panel (105), and the controller (104) in a convertible design. It can be used to apply electric field stimulation to different parts of the body simultaneously or to switch between different stimulation modes.

[0052] The electric field generator (101 ) is from a direct current (DC), alternating current (AC), pulse generator, high and low frequency, neutral stimulation, or a combination of current generator sources, more preferably from a portable pulse generator (i.e. power bank and / or portable battery). The advantages of using these electrical sources as the electric field generator are as follows: i. Direct current (DC): the usage of DC electric fields can provide steady and uniform electric field stimulation, affecting cellular membrane potential, cell support, and orientation. DC can induce electrophoresis to stimulate cell movement in response to the electric field and can be applied in various applications, including but not limited to wound healing, and bone and nerve regeneration. ii. Alternating current (AC): AC generates periodic and non-uniform electric field stimulation, influencing cell membrane capacitance, ion oscillation, and cell polarization. AC can induce dielectrophoresis to stimulate polarized cell movement in response to electric field gradient and can be utilised in cell sorting, manipulation, and stimulation. iii. Pulse generator: produces short and intermittent bursts of electric charge, creating transient and intense electric field stimulation that affects cell membrane permeability, intracellular signalling, and cell apoptosis. Pulse generator induces electroporation in response to the electric field and can be employed in drug delivery and cancer therapy. iv. High frequency: generates electric field using a high rate of electric charge, creating a rapid and strong electric field stimulation affecting cell membrane impedance, ion resonance, and cell heating. High frequency induces electrothermal effect in response to electric field and can be used in tissue ablation, welding and imaging. v. Low frequency: generates electric fields using a low electric charge rate change, creating slow and weak electric field simulation that affects cell membrane polarization, ion diffusion, and cell migration. The low-frequency electric field can be used in tissue engineering, repair, and regeneration. vi. Neutral stimulation: generates a balanced and symmetrical electric charge flow. Neutral stimulation creates stable and moderate electric field stimulation that affects cell membrane equilibrium, ion exchange, and cell homeostasis inducing electrochemical effects. This can be used in tissue preservation, detoxification and restoration.

[0053] Moving forward, referring to Figure 1 , the illustration depicts the connection setup of the main electric conductive plate (103) design. The electric field generator (101 ) is connected by one end of a cable (102) to the controller (104). The controller (104) is then connected to a plurality of cables leading to specific electric conductive plates, each directed to plates designed for therapy related to a specific organ or body system (i.e. kidney or muscular system). This dynamic therapy configuration allows more personalized therapy, wherein the electric conductive plates can provide targeted electric field stimulation to the different areas of the body based on the user's requirements.

[0054] In addition, the present invention introduces the electric conductive plate (103) characterised by a moveable electric conductive plate (103a) and fixed electric conductive plate (103b) with the ability to fold between the panels and a well- ventilated design. The ventilation airways serve multiple purposes, including providing good aeration during operation, preventing overheating and heat accumulation, and enhancing user’s comfort by promoting airflow and reducing the risk of discomfort. The electric conductive plates (103) are made from conductive materials, including but not limited to copper, silver, gold, carbon nanotubes, indium tin oxide, conductive polymers, silver nanowires, metal oxide, and carbon-based materials. The utilization of various conductive materials provides versatility and allows for customization based on conductivity, flexibility, and cost.

[0055] Additionally, the electric conductive plates (103) are configured as capacitancebased electrodes. In an aspect, the present invention’s capacitance-based electrode configuration can include but is not limited to parallel, cylindrical, spherical, variable, multi-layered ceramic, or film capacitors or a combination of capacitor types, more preferably parallel capacitor and / or variable capacitor.

[0056] Generally, a capacitor functions to store electric charge and energy by creating an electric field between two conductors. The capacity of the capacitors to store energy depends on their capacitance which is determined by the shape, size, and distance of the conductors as well as the material between them. The effect of the electric field on the material depends on the frequency and voltage of the electric field, along with the material characteristics. The characteristics of these capacitors include: i. Parallel capacitor consists of two flat plates, and the electric field generated between the plates is uniform and perpendicular to the plates. ii. Variable capacitor is an adjustable capacitor where the capacitance can be changed by adjusting the distance or area of the plate. This can be achieved by using a movable plate, a rotating plate, or a sliding plate. It can be used to tune the frequency of a circuit or to control electric field strength between the plates. iii. Cylindrical capacitor consists of two concentric cylindrical conductors of different radii. The electric field between the cylinders is radial and not uniform. iv. Spherical capacitor consists of two concentric spherical conductors of different radii which also provide radial and non-uniform. v. Multi-layered ceramic capacitor consists of multiple layers of ceramic material and metal electrodes stacked together. vi. Film capacitor consists of two thin metal foils separated by a thin plastic film.

[0057] The parallel capacitor, variable capacitor, or the combination thereof is more preferable, with a preference towards parallel capacitors due to their excellence in generating a uniform electric field between the plates. Uniformity is a crucial feature in the application, ensuring consistent treatment and suitability for targeting specific regions within an organ such as the liver cells. Parallel plates provide more control over the treatment area and can be positioned to focus on specific regions of the liver, kidney, spine, and whole body to boost cells such as hepatocytes, Kupffer cells, stem cells, inflammatory cells, bone marrow aspirate concentrate, plasma, pancreatic polypeptide, alpha, beta, and delta cell of the pancreas, duct cell, or endothelial cells.

[0058] Meanwhile, variable capacitors allow adjustments to both the capacitor and electric field. For instance, a configuration with closer plates generates a stronger electric field, whereas a wider separation weakens the field. In addition, variable capacitors can be arranged in parallel configurations to create a setup similar to parallel plates. This adds value to the use of variable capacitors, as the capacitance can be adjusted, providing total control over the electric field strength between the plates. This is advantageous for target-specific applications or to accommodate individual preferences. Variable capacitors can be employed in various configurations including cylindrical or spherical to generate different electric field patterns. In regards to the capacitance-based electrode configuration, the choices of waveform for the capacitance-based electric field become crucial. The capacitancebased electric field is in the form of sinusoidal wave, square wave, triangle wave, sawtooth wave, and pulse wave, more preferably a combination of different waveforms to maximise the therapeutic benefits. The reason is that different waveforms can influence various effects on the cell, as described in the following: i. Sinusoidal wave: suitable for gradual and sustained improvement of organ function as it is the most tolerated wave by tissues and cells. It can be used to support the general well-being of tissues and may promote immune system balance over time. ii. Square wave: used to enhance short-term organ function and targeted immune system stimulation. It can induce strong cellular responses and is effective for specific applications that require immediate changes. iii. Triangle wave: provides balanced and linear changes with gradual transitions, is suitable for tissue health, and assists in maintaining immune system stability. iv. Sawtooth wave: this waveform combines gradual and sharp transitions, providing versatility for balanced organ functions and improved immune system. It can also be used for controlled cell stimulation. v. Pulse wave: provides more precise control over pulse duration, frequency, and amplitude, allowing targeted immune system stimulation, organ function improvement, and minimising unwanted effects to nearby tissues.

[0059] Based on the description of the waveforms, the present invention teaches the utilisation of one type or a combination of waveforms to provide electric field stimulation, as it provides a more effective and comprehensive therapy. For example, sinusoidal or triangular waves can be beneficial for general tissue health and immune system balance, while square and pulse waves can be used in targeted immune system responses and acute organ function enhancement. Additionally, these waveforms can be characterized in the range of -60 V to +60 V (peak-to-peak voltage of 120 V).

[0060] The electric field generated is controlled by the controller (104), which is capable of regulating variable modes of the electric field to target different organ's needs. The controller (104) is characterized by its capability to operate in wired, wireless, or a combination of both modes, connecting to the electric conductive plate (103) either via cables (102) or Bluetooth. The controller (104) is capable of being a multimode or artificial intelligence (Al) controlled programme controller, indicating its ability to regulate various properties of the electric field and control the device's program. Through the Al-controlled programme mode, allows the device to sense, and control therapeutic systems, provide data analysis, and provide real-time therapy feedback to the user. The electric field properties are controlled within a frequency range of 1 Hz to 1 MHz, preferably between 5 Hz to 500 kHz. This frequency range is significant as it promotes cell migration, differentiation, and proliferation, improves immune system modulation, and influences cellular processes for tissue regeneration.

[0061] Meanwhile, the user can set the optimal voltage through the controller (104), ranging from -60 V to +60 V. This voltage is considered safe for cellular responses in organs such as the liver, kidney, herniated disc, pancreas, and others, without disrupting cellular membrane functions. At this voltage, the generated electric field can promote cellular communication for cell regeneration. Additionally, the controller (104) is a multimode program capable of controlling a combination of frequencies, voltage, time, waveform, and the distance of the movable electric conductive plate (103a) both electronically, manually, or a combination thereof. This allows the electric field therapy to stimulate, boost rejuvenation, regeneration, and revitalization of normal cells at different locations throughout the body system. For example, the frequency and voltage can be set to an intermediate frequency (10-100 kHz) with a voltage range oscillating between -60 V and +60 V to simultaneously stimulate bone marrow aspirate concentrate from the skeletal system and hepatocytes cells from the digestive system, enhancing the metabolic function of the organs and the vitality of the cells. Referring to Figures 2.1 and 2. II, the embodiment of the outlet (106) is presented in an example form of wearable attire designs. Figure 2.1 illustrates a wearable vest, with Figures 2.1 (a) and 2.1 (b) indicating the front and back views of the wearable vest, and Figure 2.1 (c) illustrates the side view of the wearable vest. Meanwhile, Figure 2. II shows the design of a wearable belt with Figure 2. II (a) an angled view of the belt, and Figure 2. II (b) shows the side view of the belt. The configuration of the outlet design is depicted, with the electric conductive plate (103) embedded in the outlet (106) designed as an attire.

[0062] Referring to Figure 3, the embodiment of the outlet in a chair or seating configuration design is presented. Figure 3a illustrates the side view, and Figure 3b illustrates the top view of the design. The overall figure details the outlet (106) in a chair and / or seating configuration, wherein the electric conductive plates (103) are in the form of moveable electric conductive plates (103a) embedded in the electrode panel (105). The fixed electric conductive plates (103b) are embedded in the outlet (106). The electrode panel (105) can be attached, detached, or retractable from and into the outlet (106), allowing the device to be adaptable in size and form to fit various user routines.

[0063] Referring to Figure 4, the embodiment of the outlet (106) is presented in a chamber configuration design for full-body holistic therapy. Figure 4a provides a top view of the chamber design, wherein the moveable electric conductive plate (103a) is embedded in the electrode panel (105), and the electrode panel (105) is retracted from the outlet (106) during use and detached back into the outlet (106) afterwards. Figure 4b describes the side view of the chamber configuration, highlighting that the moveable electric conductive plate (103a) has the added capability to detect automatically when the user changes position or turns around, ensuring a consistent distance from the skin throughout the session for optimal and accurate regional focus.

[0064] Additionally, the movable electric conductive plate (103a) can be controlled electronically, manually, or a combination through the controller (104), while the fixed electric conductive plate (103b) is embedded in the outlet (106). The height of the outlet (106) is adjustable manually or electronically to accommodate the user's body size or set at a fixed distance for less intensive general well-being mode. Figure 4c illustrates the outlet's (106) foldable capability for easy storage, where the electrode panel (105), comprising the movable electric conductive plate (103a) and fixed electric conductive plate (103b) embedded in the outlet, is retracted and folded for compact storage.

[0065] To accomplish the desired ability, the outlet (106) material can include but is not limited to, conductive polymer composites, graphene-based materials, silver nanowires film, carbon nanotubes (CNT) films, conductive textile-based materials, flexible metal foils, conductive hydrogels, or a combination thereof. These materials can distribute the electric field uniformly without causing overheating and discomfort to the user.

[0066] The present invention may be embodied in other specific forms without departing from its essential characteristics. The described embodiments are to be considered in all respects only as illustrative and not restrictive. The scope of the invention is, therefore indicated by the appended claims rather than by the foregoing description. All changes, which come within the meaning and range of equivalency of the claims, are to be embraced within their scope.

Claims

CLAIMS1. An electric field generating device (20) for boosting normal cell vitality, comprising: an electric field generator (101 ) used for outputting electric field stimulation; an end of cables (102) connected at one end to the electric field generator (101 ), and at another end to a controller (104), then further connected to a plurality of electric conductive plates (103); the electric conductive plates (103) are a capacitance-based electrode configuration; an electrode panel (105) designed to encase a plurality of movable electric conductive plates (103a) and are extendable to suit the user’s body condition; the controller (104) is a multimode controller that controls electric field signal modes to target different organs' needs; and an outlet (106) to encase a plurality of the electric conductive plates (103); the electrode panel (105); and the controller (104) in a convertible design, characterised in that the electric conductive plates (103) comprises the movable electric conductive plates (103a); a fixed electric conductive plates (103b); or a combination thereof, wherein the movable electric conductive plates (103a) are encased in the electrode panel (105); the capacitance-based electrode arrangement is a parallel capacitor; cylindrical capacitor; spherical capacitor; variable capacitor; multi-layered ceramic capacitor; film capacitor; or a combination thereof; the electric field is controlled in a frequency range of 1 Hz to 1 MHz with a voltage range oscillating between -60 V and +60 V (peak-to-peak voltage of 120 V).

2. The electric field generating device (20) according to claim 1 , wherein the device is a non-penetrative electrode.

3. The electric field generating (20) device according to claim 1 , wherein the electric field generator (101 ) is a direct current (DC), alternating current (AC), pulse generator, high and low frequency, neutral stimulation, or a combination thereof.

4. The electric field generating device (20) according to claim 1 , wherein the cables (102) are connected to the electric conductive plate (103) to direct electric field signals to electrodes targeting specific body systems, organs, the whole body, or a combination thereof.

5. The electric field generating device (20) according to claim 1 , wherein the electric conductive plate (103) provides an electric field stimulation for pain management therapy, preventing muscle atrophy, improving muscle strength, supporting muscle recovery, facilitating nerve cell growth, modulating neural activity, and alleviating neurological disorder symptoms.

6. The electric field generating device (20) according to claim 1 , wherein the electrode panel (105) is retractable and detachable.

7. The electric field generating device (20) according to claim 1 , wherein the controller (104) is wired or wirelessly connected to the electric field generator (101 ) at one end and the electric conductive plate (103) at the other end.

8. The electric field generating device (20) according to claim 1 , wherein the controller (104) is a multimode controller equipped with an artificial intelligence program capable to control a combination of frequencies, voltage, time, waveform, and distance of the movable electric conductive plate (103a) electronically, manually, or a combination thereof.

9. The electric field generating device (20) according to claim 1 , wherein the outlet (106) comprises a flexible material from at least one conductive polymer composite, at least one conductive textile-based material, or a combination thereof.

10. The electric field generating device (20) according to claim 1 , wherein the electric conductive plates (103) consist of movable electric conductive plates (103a) or fixed electric conductive plates (103b).

11. The electric field generating device (20) according to claim 10, wherein the movable conductive plates (103a) within the electrode panel (105) are interchangeable between positive, negative, and ground to control the reach of electric field coverage.

12. The electric field generating device (20) according to claim 11 , wherein movements and the waveform of the electric field generated by electric conductive plates (103) can be controlled by a controller (104) electronically, manually, or a combination thereof.

13. The electric field generating device (20) according to claim 10, wherein the material of the conductive plates (103) is a form of at least one conductive metal, at least one conductive polymer, at least one flexible metal foil, or a combination thereof.

14. The electric field generating device (20) according to claim 10, wherein the capacitance-based electric field of the conductive plate (103) comprises at least one sinusoidal wave, at least one square wave, at least one triangle wave, at least one sawtooth wave, at least one pulse wave, or a combination thereof.

15. The electric field generating device (20) according to claim 1 , wherein the outlet (106) is configured in the form of a head-worn device, a waist device, a shoe inserts, an apparel device, a designed mat, a mask, a portable electric field device, a mattress, a blanket, a pillow, a designed cushions for chairs or seating area, or a combination thereof.

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