Fat separation and purification module and fat separation and purification device

Abstract

A fat separation and purification module (1) comprises: a cylindrical member (10) that has a cylindrical shape and has a through-hole (11b) formed in an upper wall (11a) thereof, the cylindrical member (10) having an introduction port (121) for introducing, to the inside, a cleaning liquid for purifying fat tissue, and a discharge port (131) that is provided at the −Z direction-side end and is used for discharge of liquid present in the inside to the outside; a filter member (21) that is capable of moving in a cylinder axis (J1) direction inside the cylindrical member (10) and is disposed in an orientation in which the peripheral portion thereof is in contact with the inner wall of the cylindrical member (10) and the interior of the cylindrical member (10) is partitioned by the filter member (21) into two regions adjacent in the cylinder axis (J1) direction; and an operation rod (22) that is elongated, the filter member (21) being fixed to one end part of the operation rod (22) on the −Z-direction side, and the other end part of the operation rod (22) being disposed outside the cylindrical member (10) in a state in which the operation rod (22) is inserted through the through-hole (11b) in the cylindrical member (10).

Description

Fat separation and purification module and fat separation and purification device

[0001] The present invention relates to a fat separation and purification module and a fat separation and purification device.

[0002] Conventionally, adipose tissue has been collected in a bottle connected to a cannula, and then the adipose tissue has been collected from the bottle and directly reinjected into the patient without preparation. Alternatively, the adipose tissue has been manually collected directly with a syringe, then centrifuged and reinjected into the patient. For example, a device for collecting adipose tissue has been proposed, which includes a jar for storing the collected adipose tissue inside, a lid for sealing the opening of the jar, a first pipe having one end attached to a suction cannula and the other end fixed to the lid, and a second pipe having one end fixed to the lid and the other end connected to a suction pump (see, for example, Patent Document 1). In this device, the inside of the first pipe is connected to the inside of the jar, and the inside of the second pipe is connected to the inside of the jar. A negative pressure is created inside the jar using the suction pump, and the fat is collected into the jar through the suction cannula. The adipose tissue collected in the jar is then collected using a syringe.

[0003] Special Publication No. 2022-508908

[0004] However, while the device described in Patent Document 1 can collect adipose tissue while maintaining a sealed state inside the jar, it is difficult to sufficiently remove unnecessary liquid components contained in the adipose tissue, i.e., water, blood components, oily components, impurities, etc., without causing severe mechanical damage to the adipose tissue. For this reason, for example, in autologous adipose tissue transplantation surgery, there is a risk that the survival rate of the transplanted adipose tissue will be significantly reduced.

[0005] The present invention has been made in consideration of the above-mentioned reasons, and aims to provide a fat separation and purification module and a fat separation and purification device that can remove unnecessary liquid components contained in adipose tissue while reducing damage to the adipose tissue.

[0006] In order to achieve the above-mentioned object, the fat separation and purification module of the present invention is a fat separation and purification module for separating and purifying liquid components from adipose tissue, and comprises: a cylindrical member having a through hole formed in a wall closing one end in the cylindrical axis direction, and having an inlet for introducing a cleaning solution for purifying the adipose tissue inside, and an outlet provided at the other end in the cylindrical axis direction for discharging liquid present inside to the outside; a filter member that is movable in the cylindrical axis direction inside the cylindrical member, with its peripheral portion abutting the inner wall of the cylindrical member and arranged in an orientation that divides the interior of the cylindrical member into two adjacent regions in the cylindrical axis direction; and a long operating rod to which the filter member is fixed at one end in the longitudinal direction, and whose other end is inserted into the through hole and arranged outside the cylindrical member.

[0007] According to the present invention, with the tubular member positioned such that one end in the axial direction of the tubular member is positioned vertically higher than the other end, adipose tissue and cleaning fluid are introduced toward the wall blocking the one end in the axial direction of the tubular member relative to the position of the filter member inside the tubular member. The filter member is then moved vertically upward, creating a pressure difference, causing the liquid components contained in the adipose tissue and the cleaning fluid to permeate the filter member inside the tubular member and move toward the other end of the tubular member, leaving the adipose tissue from which the liquid components have been removed in a region vertically above the filter member inside the tubular member. This reduces the load on the adipose tissue, allowing the adipose tissue from which the liquid components have been removed to be positioned vertically above the tubular member relative to the filter member inside the tubular member, thereby reducing damage to the adipose tissue.

[0008] 5A is a schematic perspective view of a fat separation and purification module according to a first embodiment of the present invention. FIG. 5B is a schematic diagram showing the introduction of adipose tissue into the inside of a cylindrical member in the fat separation and purification module according to the first embodiment. FIG. 5C is a schematic diagram showing the introduction of an inert gas into the inside of a cylindrical member in the fat separation and purification module according to the first embodiment. FIG. 5D is a cross-sectional arrow view of the cylindrical member of the fat separation and purification device according to the first embodiment, taken along line A-A in FIG. 2B. FIG. 5E is a schematic diagram showing the washing of adipose tissue by stirring a mixture of adipose tissue and physiological saline in the fat separation and purification module according to the first embodiment. FIG. 5F is a schematic diagram showing the movement of the filter member toward the upper wall of the cylindrical member in the fat separation and purification module according to the first embodiment. FIG. 5G is a schematic diagram showing the movement of adipose tissue toward the syringe by rotating the filter member in the fat separation and purification module according to the first embodiment. Fig. 1 is a schematic diagram showing how adipose tissue accumulated inside a cylindrical member is collected by a syringe in the fat separation and purification module according to embodiment 1. Fig. 2 is a schematic side view showing a part of a fat separation and purification device according to embodiment 2 of the present invention. Fig. 3 is a schematic side view showing a part of a fat separation and purification device according to a modified example. Fig. 4 is a schematic side view showing a part of a fat separation and purification device according to a modified example.

[0009] (Embodiment 1) A fat separation and purification module according to this embodiment will be described below with reference to the drawings. The fat separation and purification module according to this embodiment is for separating and purifying liquid components from adipose tissue. This fat separation and purification module includes a cylindrical member having a through-hole formed in a wall closing one end in the cylindrical axis direction, and having an inlet for introducing a cleaning solution for purifying adipose tissue into the inside and an outlet provided at the other end in the cylindrical axis direction for discharging liquid present inside to the outside; a filter member that is movable inside the cylindrical member in the cylindrical axis direction, with its peripheral portion abutting the inner wall of the cylindrical member and disposed in an orientation that divides the interior of the cylindrical member into two adjacent regions in the cylindrical axis direction; and a long operating rod to which the filter member is fixed at one end in the longitudinal direction and whose other end is inserted into the through-hole and disposed outside the cylindrical member.

[0010] The fat separation and purification module according to this embodiment is for separating and purifying liquid components from adipose tissue, and as shown in FIG. 1 , includes a cylindrical tubular member 10, a filter member 21, a control rod 22, and a gas supply pipe 31. The tubular member 10 is formed, for example, from resin and has a cylindrical shape. Both ends in the axial direction, i.e., the Z-axis direction, are closed by an upper wall 11a and a lower wall 13a. A through-hole 11b that is circular in plan view is formed in the upper wall 11a. The tubular member 10 also has an inlet 111 provided in the upper wall 11a for introducing adipose tissue into the interior of the tubular member 10, and an outlet 112 provided in the upper wall 11a for discharging gas present inside the tubular member 10. The inlet 111 and the outlet 112 are provided with an inlet opening / closing valve 113 and an outlet opening / closing valve 114, respectively. Furthermore, the tubular member 10 has an inlet 121 provided in the side wall 11d for introducing a cleaning solution for purifying adipose tissue into the interior, and a recovery port 132 provided in the side wall 11d for removing the adipose tissue present inside. The inlet 121 is provided with an inlet opening / closing valve 122, and the recovery port 132 is provided with a recovery port opening / closing valve 134. The inner wall of the tubular member 10 may be formed with fine grooves having a width of 500 μm or less and a depth of 500 μm or less, or may be subjected to a surface treatment such as roughening. This reduces frictional resistance between the filter member 21 and the inner wall of the tubular member 10, thereby improving so-called sliding.

[0011] Furthermore, a blade 41 is provided on the upper wall 11a inside the cylindrical member 10, which guides fatty tissue above the filter member 21 to a collection port 132 when the filter member 21 is rotated while in contact with the filter member 21 inside the cylindrical member 10. Furthermore, the cylindrical member 10 has a discharge port 131 provided on its lower wall 13a for discharging liquid present inside to the outside. A drain cock 133 is provided at the discharge port 131.

[0012] The gas supply pipe 31 has both ends connected to the cylindrical member 10, and is provided with a gas inlet 32 ​​at approximately the center in the extending direction thereof for introducing gas into the gas supply pipe 31. Gas supply port opening / closing valves 311 and 312 are provided at both ends of the gas supply pipe 31, respectively.

[0013] The filter member 21 is disk-shaped and movable in the axial direction inside the cylindrical member 10, with its periphery abutting the inner wall of the cylindrical member 10. The filter member 21 is disposed in a position that divides the interior of the cylindrical member 10 into two adjacent regions along the cylindrical axis J1. The operating rod 22 is long and has the filter member 21 fixed to one end in the longitudinal direction, and the other end is disposed outside the cylindrical member 10 while inserted through a through-hole 11b provided in the upper wall 11a of the cylindrical member 10. The operating rod 22 can be rotated around the cylindrical axis J1 as indicated by arrow AR11 and moved up and down along the cylindrical axis J1 as indicated by arrow AR12. A disk-shaped portion 23 is provided at the other end of the operating rod 22.

[0014] Next, a method of using the fat separation and purification module 1 according to this embodiment will be described. The inlet 111 of the cylindrical member 10 of the fat separation and purification module 1 is connected to, for example, a liposuction cannula (not shown) via a tube for transferring adipose tissue (not shown). The exhaust port 112 of the cylindrical member 10 is connected to a vacuum pump (not shown) via an exhaust pipe (not shown). The inlet 121 of the cylindrical member 10 is connected to a cleaning fluid supply source (not shown) that supplies cleaning fluid for cleaning adipose tissue via a tube for transferring cleaning fluid (not shown). The cleaning fluid is, for example, physiological saline solution. The outlet 131 of the cylindrical member 10 is connected to a pump (not shown) for suctioning waste fluid via a tube for transferring waste fluid (not shown). The gas inlet 32 ​​is connected to a gas supply source (not shown) that supplies gas such as inert gas or air via a gas supply tube (not shown).

[0015] First, the filter member 21 is positioned by the operating rod 22 on the −Z side of the inlet 121 in the Z-axis direction of the cylindrical member 10 and on the +Z side of the gas inlet 32 ​​on the −Z side. The inlet valve 113 and the exhaust valve 114 are both opened, the gas supply valves 311 and 312 are closed, the inlet valve 122 is closed, the drain cock 133 is closed, and the recovery valve 134 is closed. Then, with the cannula inserted into the adipose tissue collection target, the vacuum pump is operated, and the gas inside the cylindrical member 10 is exhausted, as indicated by arrow AR22 in FIG. 2A , and the pressure inside the cylindrical member 10 is reduced. As a result, the adipose tissue FA transferred from the collection target through the tube is introduced into the +Z side of the filter member 21 inside the cylindrical member 10, as indicated by arrow AR21. That is, by exhausting the gas present inside the cylindrical member 10 through the exhaust port 112, the inside of the cylindrical member 10 is made to have a negative pressure relative to the outside of the cylindrical member 10, and the fatty tissue is sucked into the inside of the cylindrical member 10 through the inlet 111. Furthermore, the blood or tumescent fluid contained in the fatty tissue FA introduced into the +Z direction side of the filter member 21, i.e., a solution of physiological saline with adrenaline added, passes through the filter member 21 and flows out to the -Z direction side of the filter member 21, as shown by arrow AR23.

[0016] Next, after both the inlet opening / closing valve 113 and the exhaust opening / closing valve 114 are closed, the gas supply opening / closing valves 311 and 312 and the drain cock 133 are opened. As a result, as shown by arrow AR25 in FIG. 2B , gas supplied from the gas supply source is introduced into the cylindrical member 10, and the pressure inside the cylindrical member 10 reaches a preset pressure. Here, the preset pressure is, for example, atmospheric pressure. Furthermore, blood or tumescent fluid contained in the adipose tissue FA that has flowed out to the −Z direction side of the filter member 21, i.e., a solution in which adrenaline has been added to physiological saline, is sucked into the waste fluid suction pump through the outlet 131, as shown by arrow AR24.

[0017] Next, after closing the gas supply port opening / closing valves 311 and 312 and the drain cock 133, the inlet opening / closing valve 122 is opened to introduce cleaning fluid supplied from the cleaning fluid supply source into the tubular member 10. Here, as shown in FIG. 3 , the ejection axis J2 of the cleaning fluid ejected from the inlet 121 is offset in the −X direction from the cylindrical axis J1. As a result, the cleaning fluid ejected from the inlet 121, as indicated by arrow AR26, flows in a vortex along the inner wall of the tubular member 10, as indicated by arrow AR27. This achieves the effect of stirring the mixture of the adipose tissue FA and the cleaning fluid. After that, the inlet opening / closing valve 122 is closed, and the filter member 21 is raised in the +Z-axis direction inside the tubular member 10 using the operating rod 22, as shown in FIG. 4A . As the filter member 21 ascends, a pressure difference is generated between both sides of the filter member 21 in the Z-axis direction, and pressure is applied to the adipose tissue FA present on the +Z-axis side of the filter member 21. This pressure is used to filter impurities contained in the adipose tissue FA together with the washing liquid in the −Z direction of the filter member 21 through the filter member 21. If necessary, this washing is repeated multiple times.

[0018] Thereafter, the gas supply port opening / closing valve 311 and the drain cock 133 are opened, and the cleaning liquid mixed with impurities present in the cylindrical member 10 is sucked into the waste liquid suction pump through the discharge port 131. Next, after the drain cock 133 is closed, the filter member 21 is moved toward the +Z direction inside the cylindrical member 10 using the operating rod 22, as shown by arrow AR30 in FIG. 4B . At this time, the filter member 21 is positioned close to the end of the blade 41 provided on the upper wall 11a of the cylindrical member 10 on the -Z direction side. Next, as shown in FIG. 5A , the syringe 90 is attached to the recovery port 132. Here, the syringe 90 includes a long, cylindrical syringe body 901, a plunger 902 that is movable in the axial direction of the syringe body 901 inside the syringe body 901, and an operating unit 903 connected to the plunger 902. The tip of the syringe body 901 is then attached to the collection port 132 in a manner that communicates with the collection port 132. After that, the collection port opening / closing valve 134 is opened, and then the filter member 21 is rotated by the operating rod 22 as shown by arrow AR31 in FIG. 5B , thereby collecting the adipose tissue FA present on the +Z direction side of the filter member 21 toward the collection port 132 as shown by arrow AR32. Here, the blade 41 has a curved shape and guides the adipose tissue FA present on the +Z direction side of the filter member 21 toward the collection port 132 as shown by arrow AR32. This causes the adipose tissue FA present on the +Z direction side of the filter member 21 to accumulate in the collection port 132. Note that when collecting the adipose tissue FA in the collection port 132, rotating the blade 41 in a predetermined direction alone may not result in sufficient collection, and therefore, the blade 41 may, of course, be rotated in the opposite direction.

[0019] At this time, as shown in Figure 6, by moving the plunger 902 of the syringe 90 in the direction of pulling it out of the syringe body 901, the adipose tissue FA accumulated at the collection port 132 is collected into the syringe body 901 as shown by arrow AR33.

[0020] As described above, with the fat separation and purification module 1 according to the present embodiment, the tubular member 10 is positioned so that its end on the +Z direction side is positioned vertically higher than its end on the −Z direction side, and the adipose tissue and washing solution are introduced inside the tubular member 10 closer to the upper wall 11a of the tubular member 10 than the filter member 21. Next, the liquid components contained in the adipose tissue FA and the washing solution pass through the filter member 21 inside the tubular member 10 and move toward the lower wall 13a of the tubular member 10, and the adipose tissue from which the liquid components have been removed remains in the region inside the tubular member 10 closer to the upper wall 11a of the filter member 21. This reduces the load on the adipose tissue FA, and allows the adipose tissue FA from which the liquid components have been removed to be positioned closer to the upper wall 11a of the tubular member 10 than the filter member 21 inside the tubular member 10, thereby reducing damage to the adipose tissue FA.

[0021] Adipose tissue injection or transplantation generally consists of three steps: a liposuction step, a fat separation and purification step, and a fat injection step. In the first liposuction step, fat is harvested from the patient's abdomen, thigh, or other areas using a suction cannula. Generally, to reduce bleeding, tumescent fluid (i.e., a solution of saline with adrenaline added) is first injected into the patient's area to harvest the fat. Then, with negative pressure applied to the inside of the suction cannula, the suction cannula is inserted into the area to harvest the fat and aspirate the tissue. The harvested adipose tissue is a mixture of blood and tumescent fluid. In the subsequent fat separation and purification step, the harvested adipose tissue is purified by separating and washing the oil components, blood, and other water-soluble components contained therein. In the subsequent fat injection step, the purified adipose tissue is transferred to a syringe and then injected into the area to which the patient's adipose tissue is to be transplanted using an injection cannula attached to the tip of the syringe. The following methods are commonly used in the fat separation and purification step: One method involves washing the collected adipose tissue with saline and then separating the adipose tissue using a filter. Another method involves mixing the adipose tissue and lactated Ringer's solution in a bag containing a filter. Another method involves transferring the collected adipose tissue to a container such as a syringe body and leaving it to stand, separating the adipose tissue by utilizing the specific gravity of the adipose tissue and liquid components. The separated adipose tissue is then transferred back to the container, and saline is added and left to stand, separating the adipose tissue again. This series of processes is then repeated to remove impurities such as blood from the collected adipose tissue. Another method involves using a centrifuge to separate the adipose tissue from the liquid components. In this case, a weighted filter member is placed on the adipose tissue, and pressure is applied to the adipose tissue to separate it.

[0022] In autologous adipose tissue transplantation, the engraftment rate of the adipose tissue is important. While the engraftment rate depends largely on the patient's condition and characteristics, it is believed to depend primarily on the adipose tissue separation and purification method used in the fat separation and purification process. Specifically, it is believed that the engraftment rate will decrease if, during the process of separating and purifying the collected adipose tissue, unnecessary liquid components such as water, blood components, and oil are not sufficiently separated from the adipose tissue, or if excessive physical stress is applied to the adipose tissue during washing, causing damage to the adipose tissue. In this regard, the aforementioned method of separating the collected adipose tissue by leaving it stationary may result in insufficient separation of the liquid components contained in the collected adipose tissue. Furthermore, using the aforementioned centrifuge may result in excessive physical stress being applied to the adipose tissue, causing damage to the adipose tissue. Furthermore, even the aforementioned method of separating and purifying adipose tissue using a filter member may result in insufficient separation of the adipose tissue.

[0023] In contrast, the fat separation and purification module 1 according to this embodiment can sufficiently remove liquid components such as blood components and oil components that are thought to affect the engraftment rate of adipose tissue from the adipose tissue, and can also suppress damage to the adipose tissue.

[0024] (Embodiment 2) The fat separation and purification device of this embodiment includes the fat separation and purification module 1 described in embodiment 1, a support stand that supports the fat separation and purification module 1, a rotation handle that is arranged on the outside of the tubular member 10 and that rotates the filter member 21 around the tubular axis J1 of the tubular member 10 via the operating rod 22, and an axial movement handle that is arranged on the outside of the tubular member 10 and that moves the filter member 21 in the direction of the tubular axis J1 of the tubular member 10 via the operating rod 22.

[0025] As shown in Fig. 7 , the fat separation and purification device according to this embodiment includes a support base 50 that supports a fat separation and purification module 2001, and a drive unit 60 for manually driving the filter member 21. In Fig. 7 , the same components as those in Embodiment 1 are denoted by the same reference numerals as in Fig. 1 . The tubular member 2010 of the fat separation and purification module 2001 includes a first tubular portion 2011, a second tubular portion 2013, and a connecting portion 2015. The first tubular portion 2011 is cylindrical with a bottom, and a through-hole (not shown) that is circular in plan view is formed in the upper wall 11a. The second tubular portion 2013 is cylindrical with a bottom, and the inner diameter is shorter than the inner diameter of the first tubular portion 2011. The second cylindrical portion 2013 is continuous with the other end of the first cylindrical portion 2011 opposite to the end on the upper wall 11a side in the direction of the cylindrical axis J1 of the first cylindrical portion 2011, i.e., the end on the −Z direction side, via a connecting portion 2015. A discharge port 131 is provided in the lower wall 2013a that closes the end on the −Z direction side of the second cylindrical portion 2013. The connecting portion 2015 is cylindrical, continuous with the first cylindrical portion 2011 at the end on the +Z direction side and continuous with the second cylindrical portion 2013 at the end on the −Z direction side, and has a shape that expands in diameter in the +Z direction.

[0026] The support base 50 has a plurality of support columns 51, a cylindrical member support plate 52 which is plate-shaped and has a through-hole 52a which is circular in plan view and through which a portion of the cylindrical member 10 of the fat separation and purification module 1 is inserted in the center, and is supported at its periphery by the support columns 51, and a drive unit support plate 53 which is mounted on the tip of the support column 51 and supports the drive unit 60. The inner diameter of the through-hole 52a is shorter than the outer diameter of the first cylindrical portion 2011 and longer than the outer diameter of the second cylindrical portion 2013. As a result, the cylindrical member support plate 52 supports the cylindrical member 10 with the outer periphery of the through-hole 52a abutting against the side wall of the connection portion 2015 of the cylindrical member 2010 inserted into the through-hole 52a. Furthermore, the support base 50 has a plurality of tubular member holding portions 54 that abut against the end portion of the tubular member 10 on the +Z direction side and hold the tubular member 10 by sandwiching the tubular member 10 between the tubular member holding plate 52 and the tubular member 10 in the Z axis direction. The tubular member holding portions 54 are attached to the support columns 51 so as to be movable in a direction perpendicular to the Z axis direction relative to the support columns 51, as shown by arrow AR2011. The tubular member holding portions 54 are movable between a holding position where they abut against the end portion of the tubular member 10 on the +Z direction side and hold the tubular member 10, and a standby position where they wait outside the projection area of ​​the tubular member 10 on the +Z direction side.

[0027] The drive unit 60 includes a slider 61 that can move freely in the Z-axis direction together with the operating rod 22, a gear 62, and an axial movement handle 63 that is operated to move the operating rod 22 and slider 61 in the Z-axis direction. The slider 61 includes a rotor 612 having a columnar locking portion 611 to which the disk-shaped portion 23 at the end of the operating rod 22 on the +Z direction side is fixed, and a rotor support portion 613 that rotatably supports the rotor 612. The locking portion 611 has a so-called ball lock structure in which the disk-shaped portion 23 is fixed with a single touch by, for example, pressing the disk-shaped portion 23 against the locking portion 611. The gear 62 is fixed to the rotor 612 of the slider 61. The axial movement handle 63 is connected to the rotor support portion 613 of the slider 61. The drive unit 60 is supported by the drive unit support plate 53 on the +Z side of the drive unit support plate 53 so as to be rotatable about the rotation axis J3, and includes a spline shaft 64 that meshes with the gear 62, and a rotation handle 65 that is connected to the end of the spline shaft 64 on the +Z side and is operated to rotate the operating rod 22 and the rotating body 612 of the slider 61 about the rotation axis J3. A retractable operating rod cover (not shown) may be provided to cover the outside of the operating rod 22 and keep the operating rod 22 clean.

[0028] In the fat separating and purification device according to this embodiment, the support base 50 and drive unit 60 are used repeatedly multiple times, and the fat separating and purification module 1 is replaced for each patient. The portion of the fat separating and purification module 1 that comes into contact with adipose tissue inside the cylindrical member 10 is sterilized, and the inside of the cylindrical member 10 is designed to be isolated from the outside air by closing the inlet opening / closing valve 113, the exhaust port opening / closing valve 114, the introduction port opening / closing valve 122, the drain cock 133, and the gas supply port opening / closing valves 311 and 312.

[0029] As described above, according to the fat separation and purification device of this embodiment, as in embodiment 1, the fat tissue FA from which the liquid components have been removed can be placed inside the second tubular portion 2013 while reducing the load on the fat tissue FA, thereby reducing damage to the fat tissue FA.

[0030] Although the embodiments of the present invention have been described above, the present invention is not limited to the configurations of the above-described embodiments. For example, as shown in Fig. 8, a fat separation and purification module may be provided with a blade 41, an attitude adjustment handle 3043 that is operated to adjust the attitude of the blade 41, and a connecting rod 3042 that connects the attitude adjustment handle 3043 to the blade 41. Here, the connecting rod 3042 is inserted into a through-hole 3011c formed in the upper wall 11a of the tubular member 10. When the attitude adjustment handle 3043 is rotated as indicated by arrow AR3011, the attitude of the blade 41 changes accordingly as indicated by arrow AR3012.

[0031] According to this configuration, the posture of the blade 41 can be appropriately adjusted to a posture that makes it easier for the fatty tissue present on the +Z direction side of the filter member 21 to be guided to the collection port 132, thereby enabling the fatty tissue to be efficiently accumulated at the collection port 132.

[0032] In each embodiment, as shown in FIG. 9 , the module may include a base member 2071 on which the fat separation and purification module 1 is placed, a syringe holding section 2072 provided on the +Z direction side of the base member 2071 and holding the syringe 90, and a rotation lock mechanism 2073 that prevents the operating section 903 of the syringe 90 from rotating.

[0033] In the first embodiment, the fat separation and purification module 1 may be disposed on the outside of the tubular member 10, fixed to the disk-shaped portion 23 at the other end of the operating rod 22, and equipped with a handle (not shown) for rotating the filter member 21 around the cylindrical axis J1 of the tubular member 10 or moving it in the direction of the cylindrical axis J1 of the tubular member 10 via the operating rod 22.

[0034] In each embodiment, an example has been described in which one syringe 90 is attached to the tubular member 10, but this is not limited to this, and for example, the tubular member 10 may be provided with multiple recovery ports 132 to which multiple syringes 90 are each attached.

[0035] In the second embodiment, an example has been described in which the cylindrical member support plate 52 has the through hole 52a formed therein that is circular in plan view. However, the shape of the through hole 52a in plan view is not particularly limited as long as the inner area of ​​the through hole 52a is smaller than the cross-sectional area of ​​the first cylindrical portion 2011 of the cylindrical member 2010 and larger than the cross-sectional area of ​​the second cylindrical portion 2013. For example, if the first cylindrical portion and the second cylindrical portion are rectangular, the through hole 52a may be rectangular in plan view. Alternatively, the through hole 52a may have another shape in plan view, such as a polygonal shape in plan view, depending on the shapes of the first cylindrical portion and the second cylindrical portion.

[0036] Although the embodiments and modifications of the present invention have been described above, various embodiments and modifications of the present invention are possible without departing from the broad spirit and scope of the present invention. Furthermore, the above-described embodiments are intended to explain the present invention and do not limit the scope of the present invention. That is, the scope of the present invention is defined by the claims, not the embodiments. Various modifications made within the scope of the claims and the meaning of the invention equivalent thereto are considered to be within the scope of the present invention.

[0037] This application is based on Japanese Patent Application No. 2024-009295, filed on January 25, 2024. The entire specification, claims and drawings of Japanese Patent Application No. 2024-009295 are incorporated herein by reference.

[0038] The present invention is suitable as a fat separation and purification device for separating and purifying adipose tissue to be used for adipose tissue injection and adipose tissue transplantation.

[0039] 1, 2001: fat separation and purification module, 10, 2010: cylindrical member, 11a: upper wall, 13a, 2013a: lower wall, 11b, 52a, 3011c: through-hole, 11d: side wall, 21: filter member, 22: operating rod, 23: disc-shaped portion, 31: gas supply pipe, 32: gas inlet, 41: blade, 50: support base, 51: support column, 52: cylindrical member support plate, 53: drive unit support plate, 54: cylindrical member holding portion, 60: drive unit, 61: slider, 62: gear, 63: axial movement handle, 64: spline shaft, 65: rotation handle, 90: syringe, 111: inlet, 112: exhaust port , 113: inlet opening / closing valve, 114: exhaust port opening / closing valve, 121: inlet, 122: inlet opening / closing valve, 131: outlet, 132: recovery port, 133: drain cock, 134: recovery port opening / closing valve, 311, 312: gas supply port opening / closing valve, 611: locking portion, 612: rotor, 613: rotor support portion, 901: syringe body, 902: plunger, 903: operation portion, 2011: first cylindrical portion, 2013: second cylindrical portion, 2015: connection portion, 2071: base member, 2072: syringe holding portion, 2073: rotation lock mechanism, 3042: connecting rod, 3043: attitude adjustment handle, FA: adipose tissue

Claims

1. A fat separation and purification module for separating and purifying a liquid component from adipose tissue, comprising: a cylindrical member having a through-hole formed in a wall that closes one end in the cylinder axis direction, and an inlet for introducing a cleaning liquid for purifying the adipose tissue inside; and an outlet provided at the other end in the cylinder axis direction for discharging the liquid existing inside to the outside; a filter member that is movable in the cylinder axis direction inside the cylindrical member, whose circumference abuts against the inner wall of the cylindrical member, and is arranged in a posture that divides the inside of the cylindrical member into two adjacent regions in the cylinder axis direction; and an operation rod that is long, has the filter member fixed to one end in the longitudinal direction, and has the other end arranged outside the cylindrical member in a state of being inserted through the through-hole. The fat separation and purification module.

2. The fat separation and purification module according to claim 1, further comprising a handle that is arranged outside the cylindrical member, fixed to the other end of the operation rod, and rotates the filter member around the cylinder axis of the cylindrical member or moves the filter member in the cylinder axis direction of the cylindrical member through the operation rod.

3. The cylindrical member further has a recovery port for taking out the adipose tissue existing inside the cylindrical member, and further comprises a blade that is provided on the wall inside the cylindrical member and guides the adipose tissue existing on the wall side of the filter member to the recovery port when the filter member is rotated in a state where the filter member abuts against the wall inside the cylindrical member. The fat separation and purification module according to claim 1 or 2.

4. The cylindrical member further has an inlet for introducing the adipose tissue inside and an exhaust port for discharging the gas existing inside, and sucks the adipose tissue from the inlet into the inside of the cylindrical member in a state where the inside of the cylindrical member is under negative pressure with respect to the outside of the cylindrical member by exhausting the gas existing inside the cylindrical member through the exhaust port. The fat separation and purification module according to claim 1 or 2.

5. The cylindrical member is a bottomed cylinder with the through hole formed in the bottom wall, and includes a first cylindrical portion having the inlet, and a second cylindrical portion that is cylindrical and continuous with the other end on the wall side opposite to one end in the cylinder axis direction of the first cylindrical portion and has the outlet. The fat separation and purification module according to claim 1 or 2.

6. A fat separation and purification module for separating and purifying a liquid component from adipose tissue, a support base for supporting the fat separation and purification module, and a drive unit fixed to the support base and driving the fat separation and purification module. The fat separation and purification module includes a cylindrical member having a first through hole formed in a wall that closes one end in the cylinder axis direction, an inlet for introducing a cleaning liquid for purifying the adipose tissue inside, and an outlet provided at the other end in the cylinder axis direction for discharging the liquid existing inside to the outside; a filter member that is movable in the cylinder axis direction inside the cylindrical member, has a peripheral portion in contact with the inner wall of the cylindrical member, and is arranged in a posture that divides the inside of the cylindrical member into two adjacent regions in the cylinder axis direction; and an operation rod that is long, has the filter member fixed to one end in the longitudinal direction, and has the other end arranged outside the cylindrical member in a state of being inserted through the first through hole. The drive unit includes a rotation handle arranged outside the cylindrical member for rotating the filter member around the cylinder axis of the cylindrical member via the operation rod, and an axial movement handle arranged outside the cylindrical member for moving the filter member in the cylinder axis direction of the cylindrical member via the operation rod. When at least one of the rotation handle and the axial movement handle is operated, the filter member is rotated or moved in the cylinder axis direction via the operation rod. A fat separation and purification apparatus.

7. The cylindrical member is a bottomed cylinder with the first through hole formed in the bottom wall, and includes a first cylindrical portion having the inlet, and a second cylindrical portion that is cylindrical and continuous with the other end on the wall side opposite to one end in the cylinder axis direction of the first cylindrical portion and has the discharge port. The support base includes at least one support column, and a cylindrical member support plate that is plate-shaped and has a second through hole formed in the central portion through which a part of the cylindrical member is inserted, and the peripheral portion is supported by the support column. The area of the inner surface of the second through hole is smaller than the cross-sectional area of the first cylindrical portion and larger than the cross-sectional area of the second cylindrical portion. The fat separation and purification device according to claim 6.

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