Mobile bioprocessing module, bioprocessing unit and bioprocessing system for performing a bioprocess

Abstract

A mobile bioprocessing module (1) for performing a bioprocess, comprising a bioreactor vessel support section (2) configured for supporting a, preferably expandable, bioreactor vessel (3) for containing a culture medium and / or cell culture, an agitation device (4) for agitating the bioreactor vessel (3), and a control device (5) for controlling the mobile bioprocessing module (1), preferably for controlling the bioprocess performed by the mobile bioprocessing module (1), is presented and described. In order to provide a mobile bioprocessing module (1) with improved handling and / or design it is proposed that the mobile bioprocessing module (1) comprises at least one module interface section (22) for detachably connecting the bioprocessing module (1) to a bioprocessing unit (34) and in that the module interface section (22) comprises, preferably consists of, at least one module power interface (23) for receiving power for the mobile bioprocessing module (1), at least one module data interface (24) for receiving data for and / or transmitting data from the mobile bioprocessing module (1) and / or at least one module gas interface (25) for receiving gas for and / or transferring gas from the mobile bioprocessing module (1). Also presented and described are a bioprocessing unit (34) and bioprocessing system (36) for performing a bioprocess.

Description

[0001] Mobile bioprocessing module, bioprocessing unit and bioprocessing system for performing a bioprocess

[0002] The present invention relates to a mobile bioprocessing module for performing a bioprocess, comprising: a bioreactor vessel support section configured for supporting a, preferably expandable, bioreactor vessel for containing a culture medium and / or cell culture, an agitation device for agitating the bioreactor vessel, and a control device for controlling the mobile bioprocessing module, preferably for controlling the bioprocess performed by the mobile bioprocessing module.

[0003] The present invention further relates to a bioprocessing unit for performing a bioprocess comprising: at least one workstation for performing a work operation, preferably a bioprocess, multiple storage locations for respectively storing at least one mobile bioprocessing module for performing a bioprocess, preferably at least one mobile bioprocessing module according to any one of claims 1 to 6, and a control unit.

[0004] The present invention further relates to a bioprocessing system for performing a bioprocess comprising: a bioprocessing unit according to any one of claims 7 to 18, and one or more mobile bioprocessing modules according to any one of claims 1 to 6 for detachable connection with the bioprocessing unit.

[0005] In recent years, the field of cell and gene therapy has garnered increasing attention. As promising therapies multiply, the focus intensifies on scaling up production systems. Some biotech firms are actively pursuing fully automated systems to simultaneously produce several batches of immune or naive cell cultures for cell and gene therapy. However, these systems encounter unique challenges. For example, cell and gene therapy may not have reached a stage where production capacities are the primary bottleneck, and there might not be enough experience for a fully autoi enter the market at profitable rates. This renders the development of such a system both challenging and cost-intensive. As customers are also still inexperienced with automated systems and extremely focused on reliability over speed, gaining customer approval entails mastering a number of complex challenges simultaneously.

[0006] When integrating several mobile bioprocessing modules into a bioprocessing unit, there are several challenges to be dealt with concerning the handling and / or design of the mobile bioprocessing modules as well as the bioprocessing unit. These challenges comprise the transport of the mobile bioprocessing modules, as a manual transport can lead to user errors, mix-up of mobile bioprocessing modules or damage to the mobile bioprocessing modules as well as the bioprocessing unit when not transported with caution. Another challenge is the fluid management of waste and media of the mobile bioprocessing modules and the bioprocessing unit as shared waste or media carries the risk of cross contamination between. A further challenge is the gas, power and data supply. Another challenge is the differentiation between the mobile bioprocessing modules, as an insufficient differentiation could also lead to a mix-up of mobile bioprocessing modules in the bioprocessing unit. This could lead to wrong work operations being performed on a mobile bioprocessing module. Another challenge is the footprint (i.e. construction space] of the mobile bioprocessing modules as well as the bioprocessing unit. Adding several supporting components to the mobile bioprocessing module makes the mobile bioprocessing modules more independent of a bioprocessing unit, however, also decreases the transportability. Storing several mobile bioprocessing modules simply next to each other in a bioprocessing unit also increases the needed space and / or decrease the space within the bioprocessing unit, which is needed to perform work operations.

[0007] Against this background, it is an object of the present invention to provide a mobile bioprocessing module for performing a bioprocess, a bioprocessing unit for performing a bioprocess and a bioprocessing system for performing a bioprocess with improved handling and / or design. The object named above is solved in accordance with regard to the mobile bioprocessing module for performing a bioprocess in that the mobile bioprocessing module comprises at least one module interface section for detachably connecting the bioprocessing module to a bioprocessing unit and in that the module interface section comprises, preferably consists of, at least one module power interface for receiving power for the mobile bioprocessing module, at least one module data interface for receiving data for and / or transmitting data from the mobile bioprocessing module and / or at least one module gas interface for receiving gas for and / or transferring gas from the mobile bioprocessing module.

[0008] The object named above is further solved with regard to the bioprocessing unit for performing a bioprocess in that at least one, preferably each, storage location of the multiple storage locations and / or the workstation respectively comprises at least one unit interface section for detachably connecting the respective mobile bioprocessing module to the bioprocessing unit, preferably to the respective storage location and / or workstation, and in that the respective unit interface section of the at least one, preferably each, storage location and / or of the workstation comprises, preferably consists of, at least one unit power interface for transmitting power to the respectively connected mobile bioprocessing module, at least one unit data interface for transmitting data to and / or receiving data from the respectively connected mobile bioprocessing module and / or at least one unit gas interface for transferring gas to and / or receiving gas from the respectively connected mobile bioprocessing module.

[0009] The object named above is further solved in accordance with the present invention by the bioprocessing system for performing a bioprocess comprising: a bioprocessing unit according to any one of claims 7 to 18, and one or more mobile bioprocessing modules according to any one of claims 1 to 6 for detachable connection with the bioprocessing unit.

[0010] Various embodiments of the mobile bioprocessing module, the bioprocessing unit and the bioprocessing system are described in the following. The individual embodiments are in each case individually applicable to the mobile bioprocessing module, the bioprocessing unit and / or the bioprocessing system. The individual embodiments may furthermore be combined with each other at will.

[0011] The mobile bioprocessing module for performing a bioprocess comprises: a bioreactor vessel support section configured for supporting a, preferably expandable, bioreactor vessel for containing a culture medium and / or cell culture. The mobile bioprocessing module can also comprise a, preferably expandable and / or single-use, bioreactor vessel for containing a culture medium and / or cell culture, preferably arranged at the bioreactor vessel support section. The term “containing a culture medium and / or cell culture" is not limited to containing a culture medium and / or cell culture, but containing a liquid associated with cellular and / or non-cellular bioprocessing, for example a culture medium and / or cell culture. In addition, the bioreactor vessel arranged at the bioreactor vessel support section and / or to be supported by the bioreactor vessel support section can be used to contain cells and / or one or more medias, preferably at various steps of the cell manufacturing process. Cell manufacturing can comprise a singular or multiple work operations, preferably unit operations, in the bioreactor vessel, which may or may not include cell expansion. The bioreactor vessel arranged at the bioreactor vessel support section and / or to be supported by the bioreactor vessel support section can comprise the liquid associated with cellular and / or non-cellular bioprocessing, wherein the liquid associated with cellular and / or non-cellular bioprocessing can comprise a (cell) culture medium, a cell culture, a cell wash buffer, a cell formulation buffer, a reagent used for culturing cells, a reagent used for cell selection, a reagent used for transduction and / or a reagent for transfection. By providing a bioreactor vessel support section the bioreactor vessel can more easily be provided as a single-use bioreactor vessel at the mobile bioprocessing module, for example instead of a bioreactor vessel integral to the mobile bioprocessing module.

[0012] In addition, the mobile bioprocessing module comprises an agitation device for agitating the bioreactor vessel. The agitation device provides adequate gas exchange in the bioreactor vessel, even to the extent that there is no need for further oxygenation. However, it is advantageous to provide an external gas supply for providing gas to the bioreactor vessel so that the mobile bioprocessing module is ready for different applications and / or conditions.

[0013] In addition, the mobile bioprocessing module comprises a control device for controlling the mobile bioprocessing module, preferably for controlling the bioprocess performed by the mobile bioprocessing module. This simplifies a precise and stable bioprocess performed by the mobile bioprocessing module. Preferably it is provided that the control device directly controls the components of, for example the interfaces, and / or the components to be arranged at the mobile bioprocessing module, for example the bioreactor vessel.

[0014] In addition, it is provided that the mobile bioprocessing module comprises at least one module interface section for detachably connecting the bioprocessing module to a bioprocessing unit. In this way connecting and / or disconnecting the mobile bioprocessing module to a bioprocessing unit, in particular to the unit interface section of the bioprocessing unit, is simplified because individual cables and / or tubes do not have to be connected in a cumbersome way. Thus, the handling of the mobile bioprocessing module is improved. The module interface section can be, preferably exclusively, arranged on one side of the mobile bioprocessing module and / or the mobile bioprocessing module comprises exclusively one module interface section to further simplify connecting and / or disconnecting.

[0015] In addition, it is provided that the module interface section comprises, preferably consists of, at least one module power interface for receiving power for the mobile bioprocessing module, at least one module data interface for receiving data for and / or transmitting data from the mobile bioprocessing module and / or at least one module gas interface for receiving gas for and / or transferring gas from the mobile bioprocessing module. This further simplifies connecting and / or disconnecting the mobile bioprocessing module to a bioprocessing unit, in particular the unit interface section of the bioprocessing unit, as the interaction, preferably connection, between the mobile bioprocessing module and the bioprocessing unit is reduced to a minimum. Preferably the module interface section comprises, preferably consists of, exclusively one module power interface for receiving power for the mobile bioprocessing module, exclusively one module data interface for receiving data for and / or transmitting data from the mobile bioprocessing module and / or exclusively one module gas interface for receiving gas for and / or transferring gas from the mobile bioprocessing module. This leads to an even more simple and more fail-safe design when connecting and / or disconnecting the mobile bioprocessing module. The module power interface, the module data interface and / or the module gas interface are preferably arranged next to each other, preferably in a row, as this leads to a compact design, which is easy to connect and / or disconnect.

[0016] The module power interface is provided for receiving electrical power, preferably with 24 V direct current. Preferably the module power interface is provided for receiving power for the agitation device, the control device, a sampling device, a power storage device, a module imaging device, a condition-interface, a temperature control device, at least one valve of the mobile bioprocessing module and / or at least one pump of the mobile bioprocessing module (the sampling device, power storage device, module imaging device, condition-interface and / or temperature control device will be described later on).

[0017] Alternatively or in addition the module data interface is provided for receiving data for and / or transmitting data from the agitation device, the control device, the sampling device, the power storage device, the module imaging device, the conditioninterface, the temperature control device, the at least one valve of the mobile bioprocessing module and / or the at least one pump of the mobile bioprocessing module. The module data interface can be configured for the reception and / or transmission of data of at least one, preferably at least two separate, network. By providing multiple, in particular separate, networks control information can be received and / or transferred via one network and other, preferably more data- intensive information, for example data from the module imaging device, can be received and / or transferred via another network. In this way the flow of control information will not be interrupted by data-intensive information.

[0018] Alternatively or in addition, the module gas interface can comprise a normally closed valve, preferably normally closed solenoid valve, for preventing the unintentional escape of gas and / or a pressure relief valve for preventing unintentional build-up of pressure, for example in case of a fault. This helps increasing the safe handling of the mobile bioprocessing module and avoids a rupture of the bioreactor vessel, which would lead to a loss of sterility and / or loss of medium comprised in the bioreactor vessel. Moreover, a pressure sensor can be connected to module gas interface. The pressure sensor can be the pressure sensor for determining the pressure in the bioreactor vessel described later on and / or be arranged downstream of the normally closed solenoid valve towards the bioreactor vessel. The normally closed solenoid valve can be used to switch on and / or off the gas supply via the module gas interface. The mobile bioprocessing module and / or the bioprocessing unit can be configured to perform a connection test, to determine if the mobile bioprocessing module is connected to the unit gas interface of the bioprocessing unit for transferring gas, preferably using the pressure sensor and / or the normally closed solenoid valve. In case gas is delivered to the mobile bioprocessing module and a pressure increase is measured via the pressure sensor, it is determined that a proper gas connection is present. In case gas is delivered to the mobile bioprocessing module and substantially no pressure increase is measured via the pressure sensor, it is determined that no proper gas connection is present. If the pressure sensor would be upstream of the module gas interface, for example in the bioprocessing unit, this test would net work as intended as an increase in pressure could be detected by the pressure sensor in the bioprocessing unit even if the mobile bioprocessing module is not correctly connected to the bioprocessing unit.

[0019] Alternatively or in addition, the module interface section can be designed for connecting the bioprocessing module to the bioprocessing unit, connecting the module interface section to the unit interface section of the bioprocessing unit, for connecting the module power interface to a unit power interface of the bioprocessing unit, for connecting the module data interface to a unit data interface of the bioprocessing unit and / or for connecting the module gas interface to a unit gas interface of the bioprocessing unit by, preferably only, moving, preferably sliding, the module interface section towards the unit interface section of the bioprocessing unit. Alternatively or in addition, the module interface section can be designed for disconnecting the bioprocessing module from the bioprocessing unit, disconnecting the module interface section from the unit interface section of the bioprocessing unit, for disconnecting the module power interface from the unit power interface of the bioprocessing unit, for disconnecting the module data interface from the unit data interface of the bioprocessing unit and / or for disconnecting the module gas interface from the unit gas interface of the bioprocessing unit by, preferably only, moving, preferably sliding, the module interface section away from the unit interface section of the bioprocessing unit. This makes the mobile bioprocessing module particularly easy to use, as there is no need to manually disconnect and / or connect individual cables and / or tubes. Connection and / or disconnection can be simply achieved by moving, in particular, sliding the mobile bioprocessing module relative to the bioprocessing unit.

[0020] The mobile bioprocessing module can comprise a module housing, wherein the bioreactor vessel support section, the agitation device, the control device and / or the module interface section are arranged on and / or at the module housing. In this way the different components are protected to at least some extent and the components can be more easily transported as a single unit. Moreover, it can be provided that the mobile bioprocessing module, preferably the module housing, comprises at least one tray section for collecting fluid medium, preferably spilled fluid medium from a bioreactor vessel arranged at the bioreactor vessel support section, a culture medium vessel arranged at the culture medium support section, a waste vessel arranged at the waste vessel support section, a wash buffer vessel arranged at the wash buffer vessel support section and / or a reagent vessel at the reagent vessel support section. Alternatively or in addition the mobile bioprocessing module, preferably the module housing can comprise at least one runner, preferably at least two oppositely arranged runners, for interacting with a handling device of the bioprocessing unit in order to move, preferably lift, the mobile bioprocessing module.

[0021] In an embodiment of the mobile bioprocessing module it is provided that the module power interface comprises a module power connector for mating with a unit power interface, preferably of the bioprocessing unit, the module power interface is designed for contactless reception of power, preferably from the bioprocessing unit, the module data interface comprises a module data connector for mating with a unit data interface, preferably of the bioprocessing unit, the module data interface is designed for contactless reception and / or transmission of data, preferably from and / or to the bioprocessing unit, and / or the module gas interface comprises a module gas connector for mating with a unit gas interface, preferably of the bioprocessing unit. By providing respective connectors a reliable and stable physical connection can be provided, which also increases safety and reliability of a bioprocess performed with the mobile bioprocessing module. A contactless design further simplifies the physical connection of the bioprocessing module to a bioprocessing unit, as fewer connectors need to be connected and / or disconnected. Moreover, a contactless design reduces the risk of failure due to wear of the respective interface.

[0022] Alternatively or in addition it is provided that the module power interface, preferably the module power connector, comprises a receptacle for mating with a spring-loaded pin connector, preferably of the bioprocessing unit, that the module power interface, preferably the module power connector, comprises a spring-loaded pin connector for mating with a receptacle, preferably of the of the bioprocessing unit, that the module data interface, preferably the module data connector, comprises a receptacle for mating with a spring-loaded pin connector, preferably of the bioprocessing unit and / or that that the module data interface, preferably the module data connector, comprises a spring-loaded pin connector for mating with a receptacle, preferably of the bioprocessing unit. Spring loaded pin connectors provide a stable and reliable connection and are in particular suitable for connection and / or disconnection by sliding the mobile bioprocessing module towards and / or away from the bioprocessing unit. The receptacle of the bioprocessing unit for mating with the spring-loaded pin connector of the module power interface and / or the spring-loaded pin connector of the bioprocessing unit for mating with the receptacle of the module power interface is preferably part of the unit interface section, preferably the unit power interface, in particular the unit power connector. Alternatively or in addition the receptacle of the bioprocessing unit for mating with the spring-loaded pin connector of the module data interface and / or the spring-loaded pin connector of the bioprocessing unit for mating with the receptacle of the module data interface is preferably part of the unit interface section, preferably the unit data interface, in particular the unit data connector.

[0023] Alternatively or in addition it is provided that the module data interface, preferably the module data connector, comprises a, preferably optical, module data connection interface for mating and / or interacting with an optical interface, preferably of the bioprocessing unit. An optical interface reduces the risk of failure due to wear of the respective interface. This is in particular the case as mating of the optical interface with another interface is not necessary. Moreover, the optical interface can also be arranged distanced away from the interface of the bioprocessing unit allowing for a more flexible arrangement of the interfaces in relation to one another. The optical interface of the bioprocessing unit is preferably an optical interface of the unit data interface.

[0024] Alternatively or in addition it is provided that the module gas interface, preferably the module gas connector, comprises a female and / or male module gas connection interface for mating with a gas interface, preferably of the bioprocessing unit. Respective connectors provide a stable and reliable connection and are less complex than connections with a spring-loaded connector. The gas interface of the bioprocessing unit is preferably the unit gas interface. In an embodiment of the mobile bioprocessing module it is provided that the mobile bioprocessing module comprises a primary identifier and / or secondary identifier for identifying the mobile bioprocessing module, wherein the primary identifier comprises a machine readable medium, preferably barcode, and / or is arranged on an outer surface of the mobile bioprocessing module, and / or the secondary identifier comprises a digital identifier, preferably a unique identifier, and / or is stored in the control device. By using a machine readable medium as the primary identifier, which primary identifier is preferably arranged on an outer surface of the mobile bioprocessing module, the mobile bioprocessing module can be identified by the bioprocessing unit even if the mobile bioprocessing module is currently not connected to the bioprocessing unit. This can for example be useful when the mobile bioprocessing module is currently arranged outside the bioprocessing unit, but preferably close to the bioprocessing unit, or at the workstation of the bioprocessing unit but not connected to the bioprocessing unit. The primary identifier can be unique identifier and / or a QR-Code, a RFID-tag, and / or a NFC-tag. This also simplifies an unambiguous identification. By using a secondary identifier comprising a digital identifier and being stored in the control device of the mobile bioprocessing module, the bioprocessing unit can reliable and unambiguous transfer data to and / or receive data from the intended mobile bioprocessing module when the mobile bioprocessing module and the bioprocessing unit are connected to each other. In comparison to a machine readable medium an identifier stored in the control device does not need an external, preferably optical, scanner to read the identifier. In particular when the bioprocessing comprises multiple storage locations this reduces the number of scanners needed, as there is no need for a scanner for each storage location as identification is made via the secondary identifier when the mobile bioprocessing module is connected in the storage location to the bioprocessing unit.

[0025] Alternatively or in addition to the primary identifier comprising a machine readable medium, the primary identifier can comprise a human-readable representation of at least a portion of, preferably the same, information of the machine readable medium. In this way a user can read the information without the use of a scanner, preferably for conforming the information of the machine readable medium.

[0026] In an embodiment of the mobile bioprocessing module it is provided that the mobile bioprocessing module comprises a sampling device for retrieving at least one sample from the bioreactor vessel and / or for processing at least one sample from the bioreactor vessel. In this way the bioprocess performed in the mobile bioprocessing module can be more easily monitored and controlled. As the sampling device is part of the mobile bioprocessing module itself the risk for cross contamination due to a retrieved and / or processed sample is reduced compared to a central sampling device of a bioprocess unit retrieving and / or processing samples of different bioprocessing modules. Moreover, sampling could be performed even when not connected to the bioprocessing unit.

[0027] Alternatively or in addition the mobile bioprocessing module comprises a module imaging device for imaging, optical sampling and / or optically determining the content of the bioreactor vessel, preferably in a conduit loop fluidically connected to the bioreactor vessel and / or in a flow cell. Performing imaging, optical sampling and / or optically determining, in particular in a loop, simplifies a continuous and non-invasive monitoring and reduces the risk of contamination. As the module imaging device is not coming into contact with the content of the bioreactor vessel itself the risk for cross contamination is further reduced and imaging and / or optical sampling could be performed even when the mobile bioprocessing module is not connected to the bioprocessing unit. The module imaging device can be configured for imaging, optical sampling and / or optically determining the cell count, viability and / or size distribution of the cell culture in the bioreactor vessel. The flow cell is connected to the bioreactor vessel and is preferably arranged in the conduit loop. The module imaging device preferably comprises at least one camera and / or at least one illumination device and / or is connected to the flow cell connected to the bioreactor vessel. Via an analysis device, for example an analysis computer with an analysis software, the cell count, viability and / or size distribution can be determined. Alternatively or in addition the mobile bioprocessing module comprises a culture medium vessel support section configured for supporting a culture medium vessel for providing culture medium to the bioreactor vessel. In this way culture medium can be transferred to the bioreactor vessel, independent from the location of the mobile bioprocessing module. For example, the mobile bioprocessing module does not need to be arranged at a certain location, for example not in the bioreactor unit or at least not in a storage location of the bioreactor unit to transfer culture medium, for example via a culture medium conduit. Moreover, by providing a culture medium vessel support section the culture medium vessel can more easily be provided as a single-use culture medium vessel at the mobile bioprocessing module, for example instead of a culture medium vessel integral to the mobile bioprocessing module. The mobile bioprocessing module can comprise a, preferably single-use, culture medium vessel.

[0028] Alternatively or in addition the mobile bioprocessing module comprises a waste vessel support section configured for supporting a waste vessel for containing waste from the culture medium vessel and / or bioreactor vessel. In this way waste can be transferred away from the bioreactor vessel and / or culture medium vessel, independent from the location of the mobile bioprocessing module. For example, the mobile bioprocessing module does not need to be arranged at a certain location, for example not in the bioreactor unit or at least not in a storage location of the bioreactor unit to transfer waste away from the bioreactor and / or culture medium vessel, for example via a waste conduit. Moreover, by providing a waste vessel support section the waste vessel can more easily be provided as a single-use waste vessel at the mobile bioprocessing module, for example instead of a waste vessel integral to the mobile bioprocessing module. The mobile bioprocessing module can comprise a, preferably single-use, waste vessel.

[0029] Alternatively or in addition the mobile bioprocessing module comprises a wash buffer vessel support section for supporting a wash buffer vessel for providing wash buffer to the sampling device. In this way wash buffer can be transferred to the sampling device, independent from the location of the mobile bioprocessing module. For example, the mobile bioprocessing module does not need to be arranged at a certain location, for example not in the bioreactor unit or at least not in a storage location of the bioreactor unit to transfer wash buffer, for example via a wash buffer conduit. Moreover, by providing a wash buffer vessel support section the wash buffer vessel can more easily be provided as a single-use wash buffer vessel at the mobile bioprocessing module, for example instead of a wash buffer vessel integral to the mobile bioprocessing module. The mobile bioprocessing module can comprise a, preferably single-use, wash buffer vessel.

[0030] Alternatively or in addition the mobile bioprocessing module comprises a reagent vessel support section for supporting a reagent vessel for providing reagent to the sampling device and / or bioreactor vessel. In this way reagent can be transferred to the sampling device and / or bioreactor vessel, independent from the location of the mobile bioprocessing module. For example, the mobile bioprocessing module does not need to be arranged at a certain location, for example not in the bioreactor unit or at least not in a storage location of the bioreactor unit to transfer reagent, for example via a reagent conduit. Moreover, by providing a reagent vessel support section the reagent vessel can more easily be provided as a single-use reagent vessel at the mobile bioprocessing module, for example instead of a reagent vessel integral to the mobile bioprocessing module. The mobile bioprocessing module can comprise a, preferably single-use, reagent vessel.

[0031] Alternatively or in addition the mobile bioprocessing module comprises a pressure sensor for determining the pressure in the bioreactor vessel. This helps maintaining optimal conditions for the bioprocess, preferably cell growth and / or product formation, while ensuring the safety and efficiency of the bioprocess. Moreover, by providing the pressure sensor at the mobile bioprocessing module, the mobile bioprocessing module does not need to be arranged at a certain location, for example not in the bioreactor unit or at least not in a storage location of the bioreactor unit to determine the pressure in the bioreactor vessel. Alternatively or in addition the mobile bioprocessing module comprises a power storage device for providing power to the bioprocessing module. In this way the different components of the mobile bioprocessing module, which need power to operate, can be operated independent of the location of the mobile bioprocessing module. The power storage device can for example be a rechargeable battery.

[0032] Alternatively or in addition the agitation device comprises a rocking motion agitator for rocking the bioreactor vessel. A rocking motion agitator provides a very advantageous gas exchange in the bioreactor vessel. The rocking motion agitator preferably performs a rocking motion and / or a wave like motion.

[0033] Alternatively or in addition the mobile bioprocessing module comprises at least one, preferably optical, condition-interface for, preferably optically, determining the pH value, preferably from a pH test element at the bioreactor vessel, the metabolite concentration of at least one metabolite, preferably from a metabolite test element at the bioreactor vessel, and / or the concentration of dissolved oxygen, preferably from a dissolved oxygen test element at the bioreactor vessel, of the content of the bioreactor vessel. The condition-interface simplifies determining the respective values, in particular when using a single-use bioreactor vessel. When the respective values and / or concentrations are determined optically there is no need to connect the condition-interface physically with the bioreactor vessel, thus reducing set-up time and improving the handling of the mobile bioreactor vessel. The condition-interface does not need to be configured for determining the pH value, metabolite concentration and / or concentration of dissolved oxygen on its own, but rather be configured for retrieving at least a part, preferably all, the information needed to determine the respective value and / or concentration. The pH test element can be a pH test strip, the metabolite test element can be a metabolite test strip and / or the oxygen test element can be an oxygen test strip. This design is in particular suitable for singleuse bio reactor vessels. In an embodiment of the mobile bioprocessing module it is provided that the mobile bioprocessing module comprises a temperature control device for controlling the temperature of the bioreactor vessel. In this way optimal conditions, in particular an optimal temperature, can be more easily ensured during the bioprocess. The temperature control device can use heated and / or cooled air for controlling the temperature. This is in particular useful as heated and / or cooled air can be easily guided around the bioreactor vessel thus simplifying a uniform heating and / or cooling of the bioreactor vessel, preferably without significantly dampening the vessel like a water bath.

[0034] In addition, it is preferably provided that the temperature control device is configured to at least partially, in particular entirely, encompass the bioreactor vessel. In this way an at least partially enclosed area is formed which allows for an easier control of temperature. This is in particular the case when heated and / or cooled air is used for controlling the temperature. The mobile bioprocessing module, preferably the module housing, can comprise a removable module housing lid preferably forming part of the temperature control device, which module housing lid at least partially encompasses the bioreactor vessel, thus allowing for an easy access to the bioreactor vessel support section without substantially compromising temperature control by the temperature control device.

[0035] Alternatively or in addition the temperature control device comprises one or more heating elements for heating the bioreactor vessel and / or the area encompassed by the temperature control device. Alternatively or in addition it is conceivable that the temperature control device comprises one or more cooling elements for cooling the bioreactor vessel and / or the area encompassed by the temperature control device. This simplifies a targeted heating and / or cooling.

[0036] Alternatively or in addition the temperature control device comprises one or more temperature sensors for detecting the temperature of the bioreactor vessel and / or the area encompassed by the temperature control device. This further simplifies a targeted heating and / or cooling.

[0037] Alternatively or in addition the temperature control device comprises one or more air circulation devices, preferably fans, for circulating air around the bioreactor vessel and / or inside the area encompassed by the temperature control device. This helps providing a uniform heating and / or cooling, as air can be easily guided around the bioreactor vessel. In particular unwanted hot spots on the bioreactor vessel, which in particular occur when heating is only provided from one side of the bioreactor vessel, can be avoided, which hotspots could negatively influence the bioprocess.

[0038] In an embodiment of the mobile bioprocessing module it is provided that the control device is configured to control and / or to communicate with the bioreactor vessel, the sampling device, the module imaging device, the culture medium vessel, the waste vessel, the wash buffer vessel, the reagent vessel, the pressure sensor, the power storage device, the agitation device and / or the temperature control device, preferably for controlling the bioprocess performed by the mobile bioprocessing module. In this way the different components of the mobile bioprocessing module can work together in a coordinated manner. This in particular simplifies performing an optimal bioprocess.

[0039] The bioprocessing unit for performing a bioprocess comprises: at least one workstation for performing a work operation, preferably a bioprocess. The work operation preferably comprises one or more unit operations. A unit operation herein preferably refers to a unit operation used for cell therapy manufacture, e.g. for manufacture of therapeutic immune cells, such as CAR T cells or NK cells. Unit operations in context of cell therapy manufacturing process may include cell enrichment, cell selection, cell activation, cell selection and / or genetic modification of cells. As used herein a unit operation is different from a step of expanding cells (even though cells may also proliferate and thus expand throughout a unit operation]. According to a preferred embodiment, the one or more unit operations are selected from: activation of the cells, preferably wherein the liquid composition comprises an activation agent, genetic modification of the cells, in particular transduction and / or transfection, preferably wherein the liquid composition comprises a genetic modification agent, in particular a transduction agent and / or a transfection agent. Both of activation of the cells and genetic modification of the cells is usually required in order to manufacture a cell therapy product, in particular cells which have been genetically modified, e.g. to target a specific cell type such as a cancer cell. This particularly refers to manufacture of CAR T cells or other immune cell types which are usually genetically modified for targeting a cell type of interest. Alternatively or in addition the work operation can comprise an aseptically connecting and / or disconnecting of components, which will be described later on in more detail. The bioprocessing unit can comprise a unit housing, wherein the workstation and / or the storage locations are arranged at least in sections in the module housing.

[0040] Additionally the bioprocessing unit comprises multiple storage locations for respectively storing at least one mobile bioprocessing module for performing a bioprocess, preferably at least one mobile bioprocessing module according to any one of claims 1 to 6. The storage locations are spaced apart from the workstation and / or the workstation is not a storage location. In the storage location cell expansion can be conducted in the bioreactor vessel of a mobile bioprocessing module stored in the storage location. Thus, the workstation can be used for the unit operations and / or connection operations, for example welding, which operations usually take less time than cell expansion but, in some cases, need more free space to be performed than cell expansion. Thus, separate locations are provided for these different steps. The bioprocessing unit can for example comprise a mobile bioprocessing module support section, in which mobile bioprocessing module support section the active element is preferably intended to perform a work operation, preferably unit operation, and / or a step of the bioprocess on a mobile bioprocessing module provided in the bioprocessing module support section. This mobile bioprocessing module support section is preferably not a storage location or part of a storage location and / or the mobile bioprocessing module support section is preferably arranged at the one or more work positions.

[0041] In addition, the bioprocessing unit comprises a control unit. The control unit is preferably configured to control the mobile bioprocessing module, preferably each mobile bioprocessing module, stored in the storage locations, the workstation, a connection device, a handling device, a fixing device, a pH-monitoring unit, a dissolved-oxygen-monitoring unit, a metabolite-monitoring unit, an unit imaging device, a gas supply unit, a unit interface section and / or an air circulation device (The connection device, handling device, fixing device, pH-monitoring unit, dissolved- oxygen-monitoring unit, metabolite-monitoring unit, unit imaging device, gas supply unit, unit interface section and air circulation device will be described later on).

[0042] In addition, it is provided that at least one, preferably each, storage location of the multiple storage locations and / or the workstation respectively comprises at least one unit interface section for detachably connecting the respective mobile bioprocessing module to the bioprocessing unit, preferably to the respective storage location and / or workstation. In this way connecting and / or disconnecting the mobile bioprocessing modules to the bioprocessing unit, in particular via the module interface section of the respective mobile bioprocessing module, is simplified because individual cables and / or tubes do not have to be connected in a cumbersome way. In this way the handling of the mobile bioprocessing module and of the bioprocessing unit is improved. The unit interface section can be, preferably exclusively, arranged on one side of the respective storage location and / or workstation and / or the storage locations and / or the workstation respectively comprise exclusively one module interface section to further simplify connecting and / or disconnecting.

[0043] Additionally it is provided that the respective unit interface section of the at least one, preferably each, storage location and / or of the workstation comprises, preferably consists of, at least one unit power interface for transmitting power to the respectively connected mobile bioprocessing module, at least one unit data interface for transmitting data to and / or receiving data from the respectively connected mobile bioprocessing module and / or at least one unit gas interface for transferring gas to and / or receiving gas from the respectively connected mobile bioprocessing module. This further simplifies connecting and / or disconnecting a mobile bioprocessing module to the bioprocessing unit, in particular via the module interface section of the respective mobile bioprocessing module, as the interaction, preferably connection, between the mobile bioprocessing module and the bioprocessing unit is reduced to a minimum. Preferably the unit interface section comprises, preferably consists of, exclusively one unit power interface for transmitting power to the respectively connected the mobile bioprocessing module, exclusively one unit data interface for transmitting data to and / or receiving data from the respectively connected mobile bioprocessing module and / or exclusively one unit gas interface for transferring gas to and / or receiving gas from the respectively connected mobile bioprocessing module. This leads to an even more simple and more fail-safe design when connecting and / or disconnecting the mobile bioprocessing module to and / or from the bioprocessing unit. The unit power interface, the unit data interface and / or the unit gas interface are preferably arranged next to each other, preferably in a row, as this leads to a compact design, which is easy to connect and / or disconnect.

[0044] The unit power interface is provided for transmitting electrical power, preferably with 24 V direct current. Preferably the unit power interface is provided for transmitting power for the agitation device, the control device, the sampling device, the power storage device, the module imaging device, the condition-interface, the temperature control device, the at least one valve of the mobile bioprocessing module and / or the at least one pump of the mobile bioprocessing module.

[0045] Alternatively or in addition the unit data interface is provided for receiving data from and / or transmitting data to the agitation device, the control device, the sampling device, the power storage device, the module imaging device, the condition-interface, the temperature control device, the at least one valve of the mobile bioprocessing module and / or the at least one pump of the mobile bioprocessing module. Alternatively or in addition the unit data interface can be configured for the reception and / or transmission of data of at least one, preferably at least two separate, network. By providing multiple, in particular separate, networks control information can be received and / or transferred via one network and other, preferably more data- intensive information, for example data from the module imaging device, can be received and / or transferred via another network. In this way the flow of control information will not be interrupted by data-intensive information

[0046] The unit interface section can be designed for connecting the respective mobile bioprocessing module to the bioprocessing unit, connecting the module interface section of the respective mobile bioprocessing module to the unit interface section, for connecting the module power interface of the respective mobile bioprocessing module to the unit power interface, for connecting the module data interface of the respective mobile bioprocessing module to the unit data interface and / or for connecting the module gas interface of the respective mobile bioprocessing module to the unit gas interface by, preferably only, moving, preferably sliding, the module interface section towards the unit interface section of the bioprocessing unit. Alternatively or in addition, the module interface section can be designed for disconnecting the respective mobile bioprocessing module from the bioprocessing unit, disconnecting the module interface section of the respective mobile bioprocessing module from the unit interface section, for disconnecting the module power interface of the respective mobile bioprocessing module from the unit power interface, for disconnecting the module data interface of the respective mobile bioprocessing module from the unit data interface and / or for disconnecting the module gas interface of the respective mobile bioprocessing module from the unit gas interface by, preferably only, moving, preferably sliding, the module interface section away from the unit interface section of the bioprocessing unit. This makes the mobile bioprocessing module and the bioprocessing unit in conjunction particularly easy to use, as there is no need to manually disconnect and / or connect individual cables and / or tubes. Connection and / or disconnection can be simply achieved by moving, in particular, sliding the mobile bioprocessing module relative to the bioprocessing unit.

[0047] In an embodiment of the bioprocessing unit it is provided that the unit power interface comprises a unit power connector for mating with a module power interface, preferably of the respectively connected bioprocessing module, the unit power interface is designed for contactless transfer of power, preferably to the respectively connected bioprocessing module, the unit data interface comprises a unit data connector for mating with a module data interface, preferably of the respectively connected bioprocessing module, the unit data interface is designed for contactless reception and / or transmission of data, preferably from and / or to the respectively connected bioprocessing module, and / or the unit gas interface comprises a unit gas connector for mating with a module gas interface, preferably of the respectively connected bioprocessing module. By providing respective connectors a reliable and stable physical connection can be provided, which also increases safety and reliability when preforming a bioprocess with the mobile bioprocessing module. A contactless design further simplifies the physical connection of a bioprocessing module to the bioprocessing unit, as less connectors need to be connected. Moreover, a contactless design reduces the risk of failure due to wear of the respective interface. In particular it is envisaged that the unit power connector is mating and / or configured for mating with a module power connector, the unit date connector is mating and / or configured for mating with a module data connector and / or the unit gas connector is mating and / or configured for mating with a module gas connector, preferably of the respectively connected bioprocessing module.

[0048] Alternatively or in addition it is provided that the respective unit power interface, preferably unit power connector, comprises a spring-loaded pin connector for mating with a receptacle, preferably of the respectively connected bioprocessing module and / or respectively connected module power interface, preferably module power connector, that the respective unit power interface, preferably unit power connector, comprises a receptacle for mating with a spring-loaded pin connector, preferably of the respectively connected bioprocessing module and / or respectively connected module power interface, preferably module power connector, that the respective unit data interface, preferably unit data connector, comprises a spring-loaded pin connector for mating with a receptacle, preferably of the respectively connected bioprocessing module and / or respectively connected module data interface, preferably module data connector, and / or that the respective unit data interface, preferably unit data connector, comprises a receptacle for mating with a spring- loaded pin connector, preferably of the respectively connected bioprocessing module and / or respectively connected module data interface, preferably module data connector. Spring loaded pin connectors provide a stable and reliable connection and are in particular suitable for connection and / or disconnection by sliding the mobile bioprocessing module towards and / or away from the bioprocessing unit.

[0049] Alternatively or in addition it is provided that the respective unit data interface, preferably unit data connector, comprises a, preferably optical, unit data connection interface for mating and / or interacting with an optical interface, preferably of the respectively connected bioprocessing module and / or module data interface, preferably module data connector. An optical interface reduces the risk of failure due to wear of the respective interface. This is in particular the case as mating of the optical interface with another interface is not necessary. Moreover, the optical interface can also be arranged distanced away from the interface of the mobile bioprocessing module allowing for a more flexible arrangement of the interfaces in relation to one another.

[0050] Alternatively or in addition it is provided that the respective unit gas interface, preferably unit gas connector, comprises a male and / or female unit gas connection interface for mating with a module gas connection interface, preferably of the respectively connected bioprocessing module and / or respectively connected module gas interface, in particular module gas connector. Respective connectors provide a stable and reliable connection and are less complex than connections with a spring- loaded connector. In an embodiment of the bioprocessing unit it is provided that the bioprocessing unit comprises a pH-monitoringunit for determining and / or controlling the pH value in a respective bioreactor vessel of at least one, preferably each, connected mobile bioprocessing module. This helps adjusting and / or maintaining optimal pH values in a bioprocess performed in a connected mobile bioprocessing module. The pH- monitoring unit can determine and / or control the pH value based on information provided by a condition-interface of the respective connected mobile bioprocessing module. The pH value can preferably be controlled by commanding the bioprocessing unit and / or the respective mobile bioprocessing module to add a reagent to the respective bioreactor vessel and / or by commanding the bioprocessing unit, preferably the gas supply unit, to adjust the gas supply and / or gas composition provided to the respective bioreactor vessel, preferably by adding CO2 to the gas composition. Commanding can be made via the control unit and / or the control device of the respective mobile bioprocessing module.

[0051] Alternatively or in addition the bioprocessing unit comprises a dissolved-oxygen- monitoring unit for determining and / or controlling the concentration of dissolved oxygen in a respective bioreactor vessel of at least one, preferably each, connected mobile bioprocessing module. This helps adjusting and / or maintaining optimal dissolved oxygen concentrations in a bioprocess performed in a connected mobile bioprocessing module. The dissolved-oxygen-monitoring unit can determine and / or control the dissolved-oxygen concentration based on information provided by a condition-interface of the respective connected mobile bioprocessing module. The dissolved-oxygen concentration can preferably be controlled by commanding the respective mobile bioprocessing module, preferably the agitation device of the respective mobile bioprocessing module, to adjust the agitation on the respective bioreactor vessel and / or by commanding the bioprocessing unit, preferably the gas supply unit, to adjust the gas supply and / or gas composition provided to the respective bioreactor vessel. Commanding can be made via the control unit and / or the control device of the respective mobile bioprocessing module. Alternatively or in addition the bioprocessing unit comprises a metabolite-monitoring unit for determining the concentration of at least one metabolite in a respective bioreactor vessel of at least one, preferably each, connected mobile bioprocessing module. This helps adjusting and / or maintaining optimal metabolite concentrations in a bioprocess performed in a connected mobile bioprocessing module. The metabolitemonitoring unit can determine and / or control the dissolved-oxygen concentration based on information provided by a condition-interface of the respective connected mobile bioprocessing module. The metabolite concentration can be preferably be controlled by commanding the bioprocessing unit and / or the respective mobile bioprocessing module to adjust the culture medium supply. Commanding can be made via the control unit and / or the control device of the respective mobile bioprocessing module.

[0052] Alternatively or in addition the bioprocessing unit comprises a unit imaging device for imaging, optical sampling and / or optically determining the content, preferably the cell count, viability and / or size distribution of the cell culture, of a bioreactor vessel of at least one, preferably each, connected mobile bioprocessing module. Performing imaging, optical sampling and / or optically determining simplifies a continuous and non-invasive monitoring and reduces the risk of contamination. The unit imaging device preferably comprises at least one camera and / or at least one illumination device and / or is connected to a flow cell of a bioreactor vessel of at least one, preferably each, connected mobile bioprocessing module. Via an analysis device, for example an analysis computer with an analysis software, the cell count, viability and / or size distribution can be determined.

[0053] Alternatively or in addition the bioprocessing unit comprises a gas supply unit for supplying gas to a respective bioreactor vessel of at least one, preferably each, connected mobile bioprocessing module, preferably via the respective unit gas interface, in particular unit gas connector. In this way gas can be reliably provided to the respective mobile bioprocessing modules. Alternatively or in addition it is also conceivable that the bioprocessing module comprises the gas supply unit for supplying gas to the bioreactor vessel of the bioprocessing module. For the mobile bio processing module the gas supply unit can be designed substantially in the same way as for the bioprocessing unit.

[0054] In an embodiment of the bioprocessing unit it is provided that the gas supply unit comprises for at least one, preferably each, storage location of the multiple storage locations and / or for the workstation respectively at least one, preferably at least three, primary gas conduits for respectively transferring at least one gas. By providing gas conduits for the storage locations, in particular each storage location, and / or workstation multiple mobile bioprocessing modules can be supplied simultaneously with gas, for example to expand cells. Moreover, providing respectively three primary gas conduits simplifies adjusting the gas composition for each storage location and / or the workstation individually, thus simplifying it to provide to each mobile bioprocessing module the currently optimal gas composition. Preferably at least two, preferably at least three of the primary gas conduits transfer a different gas, preferably air, CO2 and / or 02.

[0055] In addition, preferably, for at least one, preferably each, storage location of the multiple storage locations and / or for the workstation a mass flow controller is provided at each respective primary gas conduit for metering gas in the respective primary gas conduit. This helps in individually adjusting the gas composition and / or gas supply, thus providing to mobile bioprocessing module the currently optimal gas composition and / or supply.

[0056] Alternatively or in addition, preferably, a non-return valve is provided at the output of each respective mass flow controller. This can help preventing problems of the gas supply unit. For example, without the non-return valves gas could be driven from one primary gas conduit to another primary gas conduit. Such an error might not be detected when only inspecting the flow rate of a gas. The non-return valve is configured to prevent unwanted flow of gas upstream of the respective mass flow controller and / or upstream of the primary gas conduit it is installed to.

[0057] Alternatively or in addition, preferably, the respective primary gas conduits are merged into a secondary gas conduit, connected to the unit gas interface, preferably unit gas connector, of the respective storage location and / or workstation. In this way a single gas line can be provided via a single unit gas connector and / or unit gas interface to the bioprocessing unit. This simplifies providing a compact unit interface section and simplifies connecting and / or disconnecting a mobile bioprocessing module and the bioprocessing unit.

[0058] Alternatively or in addition, preferably, a pressure relief valve is provided at the respective secondary gas conduit. The pressure relief valve is configured for preventing unintentional build-up of pressure, for example in case of a fault. This helps increasing the safety of the mobile bioprocessing module and avoids a rupture of the bioreactor vessel, which would lead to a loss of sterility and / or loss of medium comprised in the bioreactor vessel.

[0059] In an embodiment of the bioprocessing unit it is provided that at least one, preferably each, storage location of the multiple storage locations comprises respectively at least one fixing device for fixing the respective mobile bioprocessing module to and / or for preventing the unintended discharge of the respective mobile bioprocessing module from the respective storage location. In this way a safe storing of mobile bioprocessing modules is ensured. The fixing device is in particular provided for preventing an unintended discharge of a respectively stored mobile bioprocessing module, for example due to an accidental collision of a worker with the bioprocessing unit or in case of other unintended movements of the bioprocessing unit, for example due to an earthquake.

[0060] In addition, it is preferably provided that the fixing device comprises a barrier, preferably arranged at the bottom of the receiving chamber of the respective storage location, for reducing the height of the free space of the respective storage location at least in sections. In this way a constructive simple way is provided to prevent an unintended discharge. To remove the mobile bioprocessing module from the respective storage location, the mobile bioprocessing module needs to be lifted above the barrier.

[0061] Alternatively or in addition, preferably, the fixing device comprises at least one fixing element which fixing element is moveable between a fixing position for fixing the respective mobile bioprocessing module and a release position for releasing the respective mobile bioprocessing module. In this way the mobile bioprocessing module can be secured and freed at will. This on the one hand increases the safety of the bioprocessing unit. On the other hand, this can be used to prevent the mix-up of mobile bioprocessing modules as, for example, only the removal of an intended mobile bioprocessing module can be granted using the fixing element.

[0062] Alternatively or in addition, preferably, the fixing element is designed to be normally closed in the fixing position. This further increases safety as the fixation is ensured even if the bioprocessing unit is cut off from power.

[0063] In an embodiment of the bioprocessing unit it is provided that the bioprocessing unit comprises at least one, preferably optical, scanner for scanning a primary identifier, preferably machine readable medium, in particular barcode, of the mobile bioprocessing module. This can be used to identify a bioprocessing unit even if the respective mobile bioprocessing module is currently not connected to the bioprocessing unit. This can for example be useful when the mobile bioprocessing module is currently arranged outside the bioprocessing unit, but preferably close to the bioprocessing unit, or at the workstation of the bioprocessing unit but not connected to the bioprocessing unit. The scanner can be arranged at the roof of the unit housing and / or the scanner can scan towards the workstation and / or downwards. This is in particular useful to identify a mobile bioprocessing module in the workstation. In addition, it is preferably provided that, the control unit is configured to prevent performing a bioprocess by the workstation on the mobile bioprocessing module provided in the workstation and / or to issue an alert when a primary identifier of the mobile bioprocessing module provided in the workstation does not match an expected primary identifier. In this way a mix-up of mobile bioprocessing modules can be prevented and thus performing a work operation on the wrong cell culture can be avoided.

[0064] In an embodiment of the bioprocessing unit it is provided that the control unit is configured for detecting, preferably via the unit power interface and / or the unit data interface, if the mobile bioprocessing module is connected to a respective storage location of the multiple storage locations. In this way it can be detected when transfer of data, gas and / or power should be initiated and / or terminated.

[0065] Alternatively or in addition it is provided that the control unit is configured for actuating the respective fixing element of at least one, preferably each, storage location of the multiple storage locations if the connection of the mobile bioprocessing module to the respective storage location is detected by the control unit. In this way a fixation of the mobile bioprocessing module is initiated when a bioprocessing module is stored. This also increases the safety of the bioprocessing unit as power, gas and / or data is only transferred when a bioprocessing module is stored and connected.

[0066] Alternatively or in addition it is provided that the control unit is configured for initiating the transfer of power, data and / or gas, preferably via the unit power interface, the unit data interface and / or the unit gas interface, to the mobile bioprocessing module if the fixation of the respective mobile bioprocessing module via the fixing device of the respective storage location of the multiple storage locations is detected by the control unit. This increases the safety of the bioprocessing unit as power, gas and / or data is only transferred when a bioprocessing unit is properly fixed and cannot be unintentionally discharged from the storage location. In an embodiment of the bioprocessing unit it is provided that at least one, preferably each, storage location of the multiple storage locations comprises a receiving chamber for receiving a respective mobile bioprocessing module. This helps safely storing the mobile bioprocessing modules in the storage locations.

[0067] Alternatively or in addition it is provided that at least one, preferably each, storage location of the multiple storage locations comprises at least one, preferably at least two, in particular oppositely arranged, guiding element for guiding a respective mobile bioprocessing module in the respective storage location, preferably in the receiving chamber of the respective storage location. This helps moving, in particular sliding, a mobile bioprocessing module into the respective storage location, in particular receiving chamber, and / or removing, in particular sliding, the mobile bioprocessing module out of the respective storage location, in particular receiving chamber.

[0068] Alternatively or in addition it is provided that at least one, preferably each, storage location of the multiple storage locations comprises a stop element, preferably adjacent to an open end of the respective receiving chamber, for preventing a mobile bioprocessing module slipping out of the respective storage location. The stop element and the fixing device can be the same component or different components. The stop element is used to prevent an unintended discharge of a respective mobile bioprocessing module, for example due to an accidental collision of a worker with the bioprocessing unit or in case of other unintended movements of the bioprocessing unit, for example due to an earthquake.

[0069] Alternatively or in addition it is provided that the multiple storage locations are stacked on one another. This layout of the storage locations leads to a better floor space utilization. Moreover, this layout allows for an easy access of mobile bioprocessing modules stored in the storage locations, in particular by a handling device, since it is not necessary to reach into the depths of the room to retrieve different stored mobile bioprocessing modules.

[0070] In an embodiment of the bioprocessing unit it is provided that the bioprocessing unit comprises a handling device for moving, preferably lifting, the mobile bioprocessing module, preferably within a unit housing of the bioprocessing unit. In this way moving a mobile bioprocessing module can be done at least partially automatically, thus enabling a user to concentrate on other work, for example work that is too complex to be performed by the bioprocessing unit. Moreover, this helps avoiding mix-up of mobile bioprocessing modules, as the handling device retrieves or stores mobile bioprocessing modules based on the information of the control device and / or control unit. When lifting the handling device can retrieve and / or store mobile bioprocessing modules arranged on top of each other and / or can be used to lift a mobile bioprocessing module above a fixing device and / or stop element to remove and / or store the mobile bioprocessing unit from and / or in the respective storage location.

[0071] In addition, it is preferably provided that the handling device comprises a at least one fork element and / or at least one support tray for supporting a bioprocessing module during the movement, preferably lifting, by the handling device. This simplifies safely and stably lifting a mobile bioprocessing module, thus reducing the risks of components of the mobile bioprocessing module, for example the bioreactor vessel, being moved unintentionally or being otherwise affected by the movement. A bioprocess can thus also be continued substantially unaffected during the movement, in particular lifting.

[0072] Alternatively or in addition it is preferably provided that the handling device is configured for moving, preferably lifting, the mobile bioprocessing module to a storage location of the multiple storage locations, to the workstation, between different storage locations of the multiple storage locations and / or between the workstation and a storage location of the multiple storage locations. The handling device can thus substantially freely move a mobile bioprocessing module within the bioprocessing unit to a location where a work operation and / or certain step of the bioprocess is intended to be performed.

[0073] Alternatively or in addition it is preferably provided that the handling device is configured to support the mobile bioprocessing module in the workstation, preferably while at least one of the work operations and / or at least one step of the bioprocess is performed on the mobile bioprocessing module. In this way no step needs to be performed to remove the mobile bioprocessing module from the handling device before performing the at least one work operation and / or at least on step of the bioprocess. This is also the case after the work operation and / or bioprocess, as the mobile bioprocessing module is already on the handling device and can directly be moved back to a storage location. This also saves space in the bioprocessing unit, as the mobile bioprocessing module can be placed in the same spot as the handling device in its idle position during the at least one work operation and / or step of the bioprocess.

[0074] In an embodiment of the bioprocessing unit it is provided that the workstation comprises one or more cartridge support sections for supporting one or more cartridges. In this way dedicated sections are provided for cartridges which can, for example, comprise cell medium and / or at least on cell culture and / or interact with a mobile bioprocessing module, preferably the bioreactor vessel of the mobile bioprocessing module, for performing a work operation, preferably unit operation, and / or a step of the bioprocess. The one or more cartridge support sections can be arranged adjacent to and / or in a row with the mobile bioprocessing module support section. The one or more cartridge support sections can be arranged on one or more mobile bioprocessing bases, which one or more mobile bioprocessing bases are moveable relative to the unit housing and / or the storage locations. In this way the one or more cartridges can be preconfigured, for example by providing a consumable media vessel in the respective cartridge, before moving the cartridges into the workstation on the one or more mobile bioprocessing bases. The one or more mobile bioprocessing bases can also comprise one or more active elements for interacting with the mobile bioprocessing module and / or the one or more cartridges to perform a work operation, preferably unit operation. For example, at least one active element of the one or more mobile bioprocessing bases can comprise a pump for conveying fluid between the one or more cartridges and / or between the one or more cartridges and the mobile bioprocessing module. Alternatively or in addition the workstation comprises one or more active elements for interacting with, preferably performing a work operation on, the mobile bioprocessing module and / or the one or more cartridges arranged in the workstation. The active element can thus be used to perform or interact with the mobile bioprocessing module and / or the one or more cartridges for performing a work operation, in particular a unit operation. Thus, a user can do other, preferably more complex, work in the meantime. Alternatively or in addition this reduces the risk of contamination as the user interaction can be reduced. The one or more active elements are configured for influencing the cell culture in the mobile bioprocessing module and / or the one or more cartridges and / or for conveying fluid between the one or more cartridges and / or between the one or more cartridges and the mobile bioprocessing module. At least one of the one or more active elements is preferably movable, preferably along at least three translational and / or at least three rotatory degrees of freedom, relative to the module housing, the one or more cartridges support sections, the mobile bioprocessing module support section, the one or more mobile bioprocessing bases and / or the storage locations. This allows for a very flexible use of the active elements, as the one or more active elements can be used at almost any location where needed. Alternatively or in addition the workstation comprises one or more connection devices, preferably for aseptically connecting and / or disconnecting the one or more cartridges and the mobile bioprocessing module arranged in the workstation. Alternatively or in addition the one or more connection devices are for aseptically connecting and / or disconnecting the one or more cartridges with each other. Minimal or even no user interaction is required during disconnecting and / or connecting when using the connection device, thus reducing the risk of contamination. In addition, it is preferably provided that, the one or more active elements are configured for adding and / or removing at least one substance from a respective bioreactor vessel of the respective mobile bioprocessing module arranged in the workstation. This can preferably be used to convey the substance to at least one cartridge of the one or more cartridges. The one or more active elements configured for adding and / or removing at least one substance can preferably be the one or more active elements of the one or more mobile bioprocessing bases and / or the one or more active elements movable relative to the module housing, the one or more cartridges support sections, the mobile bioprocessing module support section, the one or more mobile bioprocessing bases and / or the storage locations.

[0075] Alternatively or in addition it is preferably provided that the one or more active elements are configured for retrieving at least one sample and / or for processing at least one sample from a respective bioreactor vessel of the respective mobile bioprocessing module arranged in the workstation. Thus, sampling can also be done directly by the bioprocessing unit. Alternatively or in addition one or more active elements are configured for retrieving at least one sample and / or for processing at least one sample from at least one cartridge of the one or more cartridges. Thus, sampling can also be performed on the cartridges, which cartridges are not part of a mobile bioprocessing module. The one or more active elements configured for retrieving at least one sample and / or for processing at least one sample can preferably be the one or more active elements of the one or more mobile bioprocessing bases and / or the one or more active elements movable relative to the module housing, the one or more cartridges support sections, the mobile bioprocessing module support section, the one or more mobile bioprocessing bases and / or the storage locations.

[0076] Alternatively or in addition it is preferably provided that the one or more connection devices are configured for connecting, preferably welding, at least one tube of the mobile bioprocessing module and / or the one or more cartridges arranged in the workstation. Therefore, minimal or even no user interaction is required when disconnecting and / or connecting, thus reducing the risk of contamination. The one or more connection devices can be movable, preferably along at least three translational and / or at least three rotatory degrees of freedom, relative to the module housing, the one or more cartridges support sections, the mobile bioprocessing module support section, the one or more mobile bioprocessing bases and / or the storage locations and / or be connected to the one or more active elements, preferably the one or more active elements preferably movable relative to the module housing, the one or more cartridges support sections, the mobile bioprocessing module support section, the one or more mobile bioprocessing bases and / or the storage locations. This allows for a very flexible use of the connection device, as it can be used at the location where needed.

[0077] In an embodiment of the bioprocessing unit it is provided that the workstation comprises one or more work positions for performing a work operation on the respective mobile bioprocessing module and / or the one or more cartridges arranged in the workstation, preferably the one or more work positions. The one or more cartridge support sections can be arranged at least temporarily, preferably when the one or more mobile bioprocessing bases are arranged in the workstation, in the one or more work positions. It is also conceivable that the one or more cartridge support sections are one or more of the one or more work positions.

[0078] In addition, it is preferably provided that the one or more work positions comprise a refill location for refilling, preferably using the one or more active elements and / or a respective culture medium vessel, wash buffer vessel and / or reagent vessel of the respective mobile bioprocessing module arranged in the refill location. Thus, for refilling a dedicated location is provided and when using the one or more active elements minimal or even no user interaction is required, thus reducing the risk of contamination, in particular cross contamination. The one or more active elements can comprise a pump to convey liquid for refilling and, preferably the one or more active elements can be used to refill the culture medium vessel with culture medium, the wash buffer vessel with wash buffer and / or the reagent vessel with reagent. Alternatively or in addition, it is preferably provided that the one or more work positions comprise an emptying location for emptying, preferably using the one or more active elements and / or a waste vessel of the respective mobile bioprocessing module arranged in the emptying location. Thus, for emptying a dedicated location is provided and when using the one or more active elements minimal or even no user interaction is required, thus reducing the risk of contamination, in particular cross contamination. The one or more active elements can comprise a pump to convey liquid for emptying and, preferably the one or more active elements can be used to empty the waste vessel and / or the bio reactor vessel.

[0079] Alternatively or in addition, it is preferably provided that the one or more work positions comprise a swapping location for swapping, preferably using the one or more active elements and / or a respective bioreactor vessel, culture medium vessel, wash buffer vessel, reagent vessel and / or waste vessel of the respective mobile bioprocessing module arranged in the swapping location. Thus, for swapping a dedicated location is provided and when using the one or more active elements minimal or even no user interaction is required, thus reducing the risk of contamination, in particular cross contamination.

[0080] In an embodiment of the bioprocessing unit it is provided that the bioprocessing unit comprises at least one, preferably multiple, air circulation device for removing heat from at least one, preferably each, of the multiple storage locations. This helps keeping the mobile bioprocessing modules, in particular the respective bioreactor vessels, at the optimal temperature. The at least one, preferably multiple, air circulation device can comprise at least one, preferably multiple, fan, which can provide reliable air circulation.

[0081] In addition, it is provided that the at least one, preferably multiple, air circulation device is stacked on one another and / or provided along the stacked storage locations. This helps keeping every stored mobile bioprocessing module at an optimal temperature at the same time. However, it is also conceivable that no air circulation devices, to reduce the noise level and the power consumption.

[0082] Alternatively or in addition it is provided that at least one, preferably multiple, air circulation device is provided between the multiple, storage locations and an open space in the bioprocessing unit. In this way the bioprocessing unit can be arranged anywhere, as there is no need for a gap provided between the unit housing and a neighboring element, for example a wall or another bioprocessing unit, arranged adjacent to the bioprocessing unit to vent air and / or suck in air. Preferably, the at least one, preferably multiple, air circulation device is arranged on a partition frame, which partition frame is part of the unit housing and / or arranged between the multiple storage locations and an open space in the bioprocessing unit.

[0083] The bioprocessing system for performing a bioprocess comprises: a bioprocessing unit according to any one of claims 7 to 18, and one or more mobile bioprocessing modules according to any one of claims 1 to 6 for detachable connection with the bioprocessing unit. The effects described before with regard to the bioprocessing unit and the mobile bioprocessing module are applicable accordingly.

[0084] Further features and advantages of the mobile bioprocessing module, the bioprocessing unit and the bioprocessing system emerge from the following description of exemplary embodiments where reference is made to the attached drawing.

[0085] In the drawing

[0086] Fig. la shows an exemplary embodiment of a mobile bioprocessing module in a perspective view,

[0087] Fig. lb shows the mobile bioprocessing module of Fig. la in a rear view, Fig. lc shows an alternative mobile bioprocessing module in a rear view,

[0088] Fig. 2 shows an exemplary embodiment of a bioprocessing unit,

[0089] Fig. 3a shows a sectional frontal view of a storage location of the bioprocessing unit of Fig. 2 for storing a mobile bioprocessing module according to Fig. lb,

[0090] Fig. 3b shows a sectional frontal view of a storage location of an alternative bioprocessing 1 unit for storing a mobile bioprocessing module according to Fig. lc,

[0091] Fig. 4 shows a sectional side view of the storage location according to Fig. 3a and

[0092] Fig. 5 shows the partition frame of the bioprocessing unit according to Fig. 2 in a side view.

[0093] Fig. la shows an exemplary embodiment of a mobile bioprocessing module 1 in a perspective view. The mobile bioprocessing module 1 comprises a bioreactor vessel support section 2 configured for supporting a, preferably expandable, bioreactor vessel 3. Moreover, the mobile bioprocessing module 1 comprises an agitation device 4 for agitating the bioreactor vessel 3 and also comprises a control device 5, which is however not depicted in Fig. la. The control device 5 can control the different components of the mobile bioprocessing module 1.

[0094] In the shown embodiment the agitation device 4 is a rocking motion agitator for rocking the bioreactor vessel 3, as this provides a very advantageous gas exchange in the bioreactor vessel 3.

[0095] Moreover, the mobile bioprocessing module 1 comprises a culture medium vessel support section 6 configured for supporting a culture medium vessel 7 for providing culture medium to the bioreactor vessel 3 and a waste vessel support section 8 configured for supporting a waste vessel 9 for containing waste from the culture medium vessel 7 and / or bioreactor vessel 3. The culture medium vessel support section 6 and the waste vessel support section 8 are provided on a tray section of the mobile bioprocessing module 1. The tray section is formed in the shown embodiment by a tray 10, which is detachably connected to the rest of the mobile bioprocessing module 1. Alternatively or in addition to the culture medium vessel support section 6 and / or the waste vessel support section 8 a wash buffer vessel support section for supporting a wash buffer vessel and / or a reagent vessel support section for supporting a reagent vessel could be provided as part of the mobile bioprocessing module, in particular on the tray section.

[0096] The mobile bioprocessing module 1 also comprises a module housing 11, which provides structural support for the different components. On an outer surface of the mobile bioprocessing module 1, in particular on an outer surface of the module housing 11, a primary identifier 12, in the embodiment shown a machine readable medium in the form of a barcode, is provided. This primary identifier 12 can be used to identify the mobile bioprocessing module 1, for example by a bioprocessing unit.

[0097] Moreover, the mobile bioprocessing module 1 comprises a bypass-line 14 in the form of a tube via which bypass-line 14 the mobile bioprocessing module 1 can be connected to a cartridge 42 outside of the mobile bioprocessing module 1. The bypassline 14 as well as other tubes, for example of the culture medium vessel 7 and the waste vessel 9, can by held by tube holders 13. These tube holders 13 allow for a more defined positioning of the tubes and also simplify welding of different components, for example the bypass-line 14 of the mobile bioprocessing module 1 to a tube of a cartridge 42 outside the mobile bioprocessing module 1 by means of a connection device described later.

[0098] In addition, the mobile bioprocessing module 1 comprises a module imaging device 15 for imaging, optical sampling and / or optically determining the content of the bioreactor vessel in a conduit loop fluidically connected to the bioreactor vessel 3, wherein the conduit loop comprises a flow cell. Moreover, the mobile bioprocessing module 1 comprises a sampling device 16 for retrieving at least one sample from the bioreactor vessel 3 and / or for processing at least one sample from the bioreactor vessel 3. In this way the condition of the cells in the bioreactor vessel 3 can be monitored reliably and precisely.

[0099] Furthermore, the mobile bioprocessing module 1 comprises an optical conditioninterface 17 for optically determining the pH value, preferably from a pH test element 18 at the bioreactor vessel, the metabolite concentration of at least one metabolite, preferably from a metabolite test element 18’ at the bioreactor vessel, and the concentration of dissolved oxygen, preferably from a dissolved oxygen test element 18” at the bioreactor vessel, of the content of the bioreactor vessel 3. This further helps in reliably and precisely monitoring the condition of the cells in the bioreactor vessel 3.

[0100] The mobile bioprocessing module 1 also comprises a module housing lid 19. The module housing lid 19 is part of a temperature control device 20, which temperature control device 20 will be described later on in more detail. The module housing lid 19 in combination with the module housing 11 encompasses the bioreactor vessel 3, thus allowing for cooled and / or heated air to be easily circulated around the bioreactor vessel 3.

[0101] The mobile bioprocessing module 1 also comprises a pressure sensor 21 for determining the pressure in the bioreactor vessel 3.

[0102] Fig. lb shows the mobile bioprocessing module 1 of Fig. la in a rear view. Here it can be seen that the bioprocessing module 1 comprises a module interface section 22 for detachably connecting the bioprocessing module 1 to a bioprocessing unit. In the shown embodiment the module interface section 22 comprises a module power interface 23 for receiving power for the mobile bioprocessing module 1, a module data interface 24 for receiving data for and / or transmitting data from the mobile bioprocessing module 1 and a module gas interface 25 for receiving gas for and / or transferring gas from the mobile bioprocessing module 1. In the embodiment of Fig. lb the module power interface 23 comprises a module power connector 26 for mating with a unit power interface of a bioprocessing unit, which module power connector 26 comprises a receptacle for mating with a spring-loaded pin connector. However, it is also conceivable that the module power interface 23 is designed for contactless reception of power, for example via induction. The module data interface 24 comprises a module data connector 27 for mating with a unit data interface of a bioprocessing unit, which module data connector 27 comprises a receptacle for mating with a spring-loaded pin connector. In addition, the module gas interface 25 comprises a module gas connector 28 for mating with a unit gas interface of a bioprocessing unit, which module gas connector 28 comprises a female module gas connection interface for mating with a unit gas interface.

[0103] Also schematically shown in Fig. lb is a power storage device 29 for providing power to the bioprocessing module 1. However, it is also conceivable that no power storage device 29 is provided.

[0104] Moreover, the control device 5 of the mobile bioprocessing module 1 is schematically shown in Fig. lb. In the control device 5 a secondary identifier, designed as digital identifier and unique identifier, is stored. This can be used to identify the mobile bioprocessing module 1 when connected to a bioprocessing unit, thus helping to avoid mix-ups of mobile bioprocessing modulesl in a bioprocessing unit.

[0105] In addition, further parts of the temperature control device 20 can be seen in Fig. lb. Schematically shown is a heating element 30 of the temperature control device 20 for heating the bioreactor vessel 3. This can be done by heating the air that is going to be circulated around the bioreactor vessel 3 in the area encompassed by the temperature control device 20, in particular the module housing lid 19. Also schematically shown is a temperature sensor 31 for detecting the temperature of the bioreactor vessel 3 and / or the area encompassed by the temperature control device 20, in particular the module housing lid 19. Moreover, an air circulation device 32, here in the form of a fan, for circulating air around the bioreactor vessel 3 and / or inside the area encompassed by the temperature control device 20, in particular the module housing lid 19, is schematically shown.

[0106] Fig. 1c shows an alternative mobile bioprocessing module 1 in a rear view. The mobile bioprocessing module 1 of Fig. lc substantially corresponds to the mobile bioprocessing module 1 of Fig. lb, therefore the same reference signs are used and in the following it will be focused on the differences between the mobile bioprocessing module 1 of Fig. lb and Fig. lc.

[0107] The mobile bioprocessing module 1 of Fig. lc is distinguished from the bioprocessing module 1 of Fig. lb only by the module data interface 24. Here the module data interface 24 is designed for contactless reception and / or transmission of data. The shown module data interface 24 comprises a module data connection interface 33 for interacting with an optical interface of a bioprocessing unit via an optical transmission as well as via a wireless transmission, here via Bluetooth. However, only one of these options would also be conceivable for the transmission of data.

[0108] Fig. 2 shows an exemplary embodiment of a bioprocessing unit 34. The bioprocessing unit 34 comprises multiple storage locations 35 for respectively storing a mobile bioprocessing module 1. The mobile bioprocessing modules 1 shown in Fig. 2 correspond to the mobile bioprocessing module 1 shown in Fig. la. The bioprocessing unit 34 and the mobile bioprocessing modules 1 together form a bioprocessing system 36.

[0109] In addition, the bioprocessing unit 34 comprises a workstation 37 for performing a work operation, for example a unit operation. Moreover, the bioprocessing unit 34 comprises a control unit 38. The bioprocessing unit 34 also comprises a unit housing 39, in which the different components of the bioprocessing unit 34 arranged at least in sections. The unit housing 39 can comprise a partition frame 40 adjacent to the storage locations 35. On the right hand side of the partition frame 40 the storage locations 35 are arranged, while at the left hand side - among other things - a free space is provided.

[0110] The workstation 37 of the bioprocessing unit 34 comprises multiple cartridge support sections 41 for respectively supporting one or more cartridges 42. In the shown embodiment the cartridge support sections 41 are part of mobile bioprocessing bases 43, which are movable relative to the unit housing 39 and / or the storage locations 35. The bioprocessing bases 43 also comprise an active element, here preferably a pump to convey fluid between the cartridges 42 and / or between at least one of the cartridges 42 and one of the mobile bioprocessing modules 1 arranged in a mobile bioprocessing module support section 44.

[0111] Moreover, the workstation 37 comprises an active element 45 as well as a connection device 46 which are connected and movable relative to the multiple cartridge support sections 41, the unit housing 39 and / or the storage locations 35. The active element

[0112] 45 arranged above the mobile bioprocessing bases 43 is designed for interacting with the mobile bioprocessing module 1 and / or the cartridges 42 arranged in the workstation 37. By interacting with the cartridges 42 and / or the bioprocessing module 1 a work operation, in particular a unit operation, can be performed on the bioprocessing module 1 and / or the cartridges 42. A work operation can for example comprise adding and / or removing at least one substance from the bioreactor vessel 3 of a mobile bioprocessing module 1, retrieving a sample and / or processing a sample from the bioreactor vessel 3 of a mobile bioprocessing module 1. The connection device 46 can aseptically connect and / or disconnect the cartridges 42 and / or the cartridges 42 and the mobile bioprocessing module 1. In the detail of Fig. 2 for example a connection of the tubes 47 of two cartridges made by the connection device

[0113] 46 is shown. In the shown embodiment the cartridge support sections 41 as well as the mobile bioprocessing module support section 44 are arranged in the work positions 48 of the workstation 37. The work positions 48 can comprise a refill location, an emptying location and / or a swapping location, wherein these locations can be theoretically any of the work positions 48 depending on the setup of the bioprocess to be performed and / or the setup of the bioprocessing unit 34.

[0114] The bioprocessing unit 34 of the shown embodiment comprises multiple optical scanners 49 for scanning the primary identifier 12 of a mobile bioprocessing module 1. In this way the mobile bioprocessing modules 1 can be identified even when not connected, for example via the module interface section 22, to the bioprocessing unit 34. The optical scanners 49 are arranged at the roof of the unit housing 39 and scan towards the workstation 37. The information retrieved from the scanners 49 can then be used for different control steps. For example, the control unit 38 can prevent performing a bioprocess by the workstation 37 on the mobile bioprocessing module 1 provided in the workstation 37 and issue an alert when the primary identifier 12 of the mobile bioprocessing module provided in the workstation 37 does not match an expected primary identifier 12.

[0115] In order to facilitate handling of the mobile bio processing modules 1 stored in the multiple storage locations 35 stacked on one another, the bioprocessing unit 34 comprises a handling device 50 for moving, preferably lifting, the mobile bioprocessing modules 1, preferably within the unit housing 39 of the bioprocessing unit 34. In the shown embodiment the handling device 50 comprises a support tray 51 for supporting a bioprocessing module 1 during the movement, however, the handling case could also comprise a fork element for supporting a bioprocessing module 1 during the movement. The handling device 50 can move a mobile bioprocessing module 1 to any one of the storage locations 35, to the workstation 37, preferably the mobile bioprocessing module support section 44, between different storage locations 35 and / or between the workstation 37, preferably the mobile bioprocessing module support section 44, and any one of the storage locations 35. This can in particular be done by an up and / or down movement, in particular lifting, of the handling device 50. Moreover, as shown in Fig. 2, the handling device 50 supports the mobile bioprocessing module 1 in the workstation 37, thus a work operation can be performed on the mobile bioprocessing module 1 while the handling device 50 supports the mobile bioprocessing module 1.

[0116] Fig. 3a shows a sectional frontal view of a storage location 35 of the bioprocessing unit 34 of Fig. 2 for storing a mobile bioprocessing module 1 according to Fig. lb. Though only one storage location 35 is shown, the other storage locations 35 are preferably designed in the same way.

[0117] The shown storage location comprises a receiving chamber 71 for receiving a mobile bioprocessing module 1 and two oppositely arranged guiding elements 72 for guiding a mobile bioprocessing module 1 in the storage location 35, in particular in the receiving chamber 71 of the respective storage location 35.

[0118] The storage location 35 also comprises a unit interface section 52 for detachably connecting a respective mobile bioprocessing module 1 to the bioprocessing unit 34. However, alternatively or in addition the workstation 37 can also comprise a respective unit interface section 52. The unit interface section 52 comprises a unit power interface 53 for transmitting power to the respectively connected mobile bioprocessing module 1, a unit data interface 54 for transmitting data to and / or receiving data from the respectively connected mobile bioprocessing module 1 and a unit gas interface 55 for transferring gas to and / or receiving gas from the respectively connected mobile bioprocessing module 1. The unit power interface 53 comprises a unit power connector 56 for mating with the module power interface 23 of the respectively connected bioprocessing module 1, wherein the unit power connector 56 comprises a spring-loaded pin connector for mating with a receptacle of the respectively connected module power connector 26. However, it is also conceivable that the unit power interface 53 is designed for contactless transfer of power, for example via induction. The unit data interface 54 comprises a unit data connector 57 for mating with the module data interface 24 of the respectively connected bioprocessing module 1, wherein the unit data connector 57 comprises a spring- loaded pin connector for mating with a receptacle of the respectively connected module data connector 27. The unit gas interface 55 comprises a unit gas connector 58 for mating with the module gas interface 25 of the respectively connected bioprocessing module 1, wherein the unit gas connector 57 comprises a male unit gas interface for mating with the respectively connected module gas connector 28.

[0119] Schematically shown is also a pH-monitoring unit 59 for determining and / or controlling the pH value in the the bioreactor vessel 3 of the mobile bioprocessing module 1 stored in the respective storage location 35, a dissolved-oxygen-monitoring unit 60 for determining and / or controlling the concentration of dissolved oxygen in the bioreactor vessel 3 of the mobile bioprocessing module 1 stored in the respective storage location 35, a metabolite-monitoring unit 61 for determining the concentration of at least one metabolite in the bioreactor vessel 3 of the mobile bioprocessing module 1 stored in the respective storage location 35 and a unit imaging device 62 for imaging, optical sampling and / or optically determining the content, preferably the cell count, viability and / or size distribution of the cell culture, in the bioreactor vessel 3 of the mobile bioprocessing module 1 stored in the respective storage location 35. These components 59, 60, 61, 62 can be provided for each storage location 35 individually, however, it is also conceivable that one or more of these components 59, 60, 61, 62 are provided, preferably once, for the entire bioprocessing unit 34 and serve each storage location 35.

[0120] The bioprocessing unit 34 moreover comprises a gas supply unit 63 for supplying gas to a respective bioreactor vessel 3 of a connected mobile bioprocessing module 1, preferably via the respective unit gas interface 55, in particular the unit gas connector 58. The gas supply unit 63 comprises for each storage location 35 and / or for the workstation 37 respectively three primary gas conduits 64 for respectively transferring a gas. One primary gas conduit 64 transfers 02, one primary gas conduit 64 transfers CO2 and one primary gas conduit 64 transfers air in the shown embodiment, however, other constellations are conceivable. A mass flow controller 65 is provided at each respective primary gas conduit 64 for metering gas in the respective primary gas conduit 64 and a non-return valve 66 is provided at the output of each respective mass flow controller 65. The three primary gas conduits 64 are merged into a secondary gas conduit 67, connected to the unit gas interface 55, in particular unit gas connector 58, of the respective storage location 35 and / or the workstation 37. In addition, a pressure relief valve 68 is provided at the respective secondary gas conduit 67.

[0121] In the shown embodiment each storage location 35 comprises at least one fixing device 69 for fixing the respective mobile bioprocessing 1 module to and / or for preventing the unintended discharge of the respective mobile bioprocessing module 1 from the respective storage location 35. Shown in Fig. 3a are two fixing elements 70 of the fixing device 69, which are moveable between a fixing position for fixing the respective mobile bioprocessing module 1 and a release position for releasing the respective mobile bioprocessing module 1, wherein the fixing element 70 is designed to be normally closed in the fixing position. However, this fixing element 70 can also be dispensed with.

[0122] The control unit 38 of the bioprocessing unit 34 is in the embodiment shown configured for detecting, preferably via the unit power interface 53 and / or the unit data interface 54, if the mobile bioprocessing module 1 is connected to the respective storage location 35. Moreover, the control unit 38 is configured for actuating the respective fixing element 70 of the storage location 35 if the connection of the mobile bioprocessing module 1 to the storage location 35 is detected by the control unit 38. In addition, the control unit 38 is configured for initiating the transfer of power, data and / or gas, preferably via the unit power interface 53, the unit data interface 54 and / or the unit gas interface 55, to the mobile bioprocessing module 1 if the fixation of the respective mobile bioprocessing module 1 via the fixing element 70 of the storage location 35 is detected by the control unit 38. Fig. 3b shows a sectional frontal view of a storage location 35 of an alternative bioprocessing 1 unit for storing a mobile bioprocessing module 1 according to Fig. lc. The bioprocessing unit 34 of Fig. 3b substantially corresponds to the bioprocessing unit 34 of Fig. 3a, therefore the same reference signs are used and in the following it will be focused on the differences between the bioprocessing unit 34 of Fig. 3a and Fig. 3b.

[0123] The bioprocessing unit 34 of Fig. 3b is distinguished from the bioprocessing unit 34 of Fig. 3a only by the unit data interface 54. In this embodiment the unit data interface 54 is designed for contactless reception and / or transmission of data from and / or to the connected mobile bioprocessing module 1. The shown unit data interface 54 comprises a unit data connection interface 73 for interacting with an optical interface of the connected mobile bioprocessing module 1 via an optical transmission as well as via wireless transmission, here via Bluetooth. However, only one of these options would also be conceivable for the transmission of data.

[0124] Fig. 4 shows a sectional side view of the storage location 35 according to Fig. 3a. The storage location 35 shown, and preferably each other storage location 35 of the bioprocessing unit 34, comprises a stop element 74 adjacent to an open end 76 of the respective receiving chamber 71 for preventing the mobile bioprocessing module 1 from slipping out of the storage location 35. The stop element 74 is part of the fixing device 69 and the stop element 74 is designed as a barrier arranged at the bottom of the receiving chamber 71 for reducing the height of the free space of the respective storage location 35 for a section.

[0125] Fig. 5 shows the partition frame 40 of the bioprocessing unit 34 according to Fig. 2 in a side view. Here multiple air circulation devices 75 for removing heat from the storage locations 35 can be seen. The air circulation devices 75 are stacked on one another and provided along the stacked storage locations 35. The air circulation devices 75 are provided between the storage locations 35 and an open space in the bioprocessing unit 34, thus simplifying the arrangement of the bioprocessing unit 10 without the need of a gap between the bioprocessing unit 34 and a neighboring element, for example a wall.

[0126] List of reference signs

[0127] 1 Mobile bioprocessing module

[0128] 2 Bioreactor vessel support section

[0129] 3 Bioreactor vessel

[0130] 4 Agitation device

[0131] 5 Control device

[0132] 6 Culture medium vessel support section

[0133] 7 Culture medium vessel

[0134] 8 Waste vessel support section

[0135] 9 Waste vessel

[0136] 10 Tray

[0137] 11 Module housing

[0138] 12 Primary identifier

[0139] 13 Tube holders

[0140] 14 Bypass-line

[0141] 15 Module Imaging device

[0142] 16 Sampling device

[0143] 17 Condition-interface

[0144] 18, 18’, 18” Test element (pH, metabolite, dissolved oxygen]

[0145] 19 Module housing lid

[0146] 20 Temperature control device

[0147] 21 Pressure sensor

[0148] 22 Module interface section

[0149] 23 Module power interface

[0150] 24 Module data interface

[0151] 25 Module gas interface

[0152] 26 Module power connector

[0153] 27 Module data connector 28 Module gas connector

[0154] 29 Power storage device

[0155] 30 Heating element

[0156] 31 Temperature sensor

[0157] 32 Air circulation device

[0158] 33 Module data connection interface

[0159] 34 Bioprocessing unit

[0160] 35 Storage location

[0161] 36 Bioprocessing system

[0162] 37 Workstation

[0163] 38 Control unit

[0164] 39 Unit housing

[0165] 40 Partition frame

[0166] 41 Cartridge support section

[0167] 42 Cartridge

[0168] 43 Bioprocessing base

[0169] 44 Mobile bioprocessing module support section

[0170] 45 Active element

[0171] 46 Connection device

[0172] 47 Tube

[0173] 48 Work position

[0174] 49 Scanner

[0175] 50 Handling device

[0176] 51 Support tray

[0177] 52 Unit interface section

[0178] 53 Unit power interface

[0179] 54 Unit data interface

[0180] 55 Unit gas interface

[0181] 56 Unit power connector

[0182] 57 Unit data connector

[0183] 58 Unit gas connector 59 pH-monitoring unit

[0184] 60 Dissolved-oxygen-monitoring unit

[0185] 61 Metabolite-monitoring unit

[0186] 62 Unit imaging device 63 Gas supply unit

[0187] 64 Primary gas conduit

[0188] 65 Mass flow controller

[0189] 66 Non-return valve

[0190] 67 Secondary gas conduit 68 Pressure relief valve

[0191] 69 Fixing device

[0192] 70 Fixing element

[0193] 71 Receiving chamber

[0194] 72 Guiding element 73 Unit data connection interface

[0195] 74 Stop element

[0196] 75 Air circulation device

[0197] 76 Open end

Claims

C l a i m s1. Mobile bioprocessing module (1) for performing a bioprocess, comprising: a bioreactor vessel support section (2) configured for supporting a, preferably expandable, bioreactor vessel [3] for containing a culture medium and / or cell culture, an agitation device [4] for agitating the bioreactor vessel (3), and a control device (5) for controlling the mobile bioprocessing module (1), preferably for controlling the bioprocess performed by the mobile bioprocessing module (1), c h a r a c t e r i z e d i n t h a t the mobile bioprocessing module [1] comprises at least one module interface section (22) for detachably connecting the bioprocessing module (1) to a bioprocessing unit (34) and in that the module interface section (22) comprises, preferably consists of, at least one module power interface (23) for receiving power for the mobile bioprocessing module (1), at least one module data interface (24) for receiving data for and / or transmitting data from the mobile bioprocessing module (1) and / or at least one module gas interface (25) for receiving gas for and / or transferring gas from the mobile bioprocessing module (1).

2. Mobile bioprocessing module (1) according to claim 1, c h a r a c t e r i z e d i n t h a t the module power interface (23) comprises a module power connector (26) for mating with a unit power interface (53), preferably of the bioprocessing unit (34), the module power interface (23) is designed for contactless reception of power, preferably from the bioprocessing unit (34), the module data interface (24) comprises a module data connector (27) for mating with aunit data interface (54), preferably of the bioprocessing unit (34), the module data interface (24) is designed for contactless reception and / or transmission of data, preferably from and / or to the bioprocessing unit (34), and / or the module gas interface (25) comprises a module gas connector (28) for mating with a unit gas interface (55), preferably of the bioprocessing unit (34), that the module power interface (23), preferably the module power connector (26), comprises a receptacle for mating with a spring-loaded pin connector, preferably of the bioprocessing unit (34), that the module power interface (23), preferably the module power connector (26), comprises a spring-loaded pin connector for mating with a receptacle, preferably of the of the bioprocessing unit (34), that the module data interface (24), preferably the module data connector (27), comprises a receptacle for mating with a spring-loaded pin connector, preferably of the bioprocessing unit (34), that the module data interface (24), preferably the module data connector (27), comprises a spring-loaded pin connector for mating with a receptacle, preferably of the bioprocessing unit (34), that the module data interface (24), preferably the module data connector (27), comprises a, preferably optical, module data connection interface (33) for mating and / or interacting with an optical interface, preferably of the bioprocessing unit (34), and / or that the module gas interface (25), preferably the module gas connector (28), comprises a female and / or male module gas connection interface for mating with a gas interface, preferably of the bioprocessing unit (34).

3. Mobile bioprocessing module (1) according to claim 1 or claim 2, c h a r a c t e r i z e d b y a primary identifier (12) and / or secondary identifier for identifying the mobile bioprocessing module (1), whereinthe primary identifier (12) comprises a machine readable medium, preferably barcode, and / or is arranged on an outer surface of the mobile bioprocessing module (1), and / or the secondary identifier comprises a digital identifier, preferably a unique identifier, and / or is stored in the control device (5).

4. Mobile bioprocessing module (1) according to any one of claims 1 to 3, c h a r a c t e r i z e d b y a sampling device (16) for retrieving at least one sample from the bioreactor vessel (3) and / or for processing at least one sample from the bioreactor vessel (3), a module imaging device (15) for imaging, optical sampling and / or optically determining the content of the bioreactor vessel (3), preferably in a conduit loop fluidically connected to the bioreactor vessel (3) and / or in a flow cell, a culture medium vessel support section (6) configured for supporting a culture medium vessel (7) for providing culture medium to the bioreactor vessel (3), a waste vessel support section (8) configured for supporting a waste vessel (9) for containing waste from the culture medium vessel (7) and / or bioreactor vessel (3), a wash buffer vessel support section for supporting a wash buffer vessel for providing wash buffer to the sampling device (16), a reagent vessel support section for supporting a reagent vessel for providing reagent to the sampling device (16) and / or bioreactor vessel (3), a pressure sensor (21) for determining the pressure in the bioreactor vessel C3), a power storage device (29) for providing power to the bioprocessing module [1], the agitation device (4) comprising a rocking motion agitator for rocking the bioreactor vessel (3), and / orat least one, preferably optical, condition-interface (17) for, preferably optically, determining the pH value, preferably from a pH test element (18) at the bioreactor vessel (3), the metabolite concentration of at least one metabolite, preferably from a metabolite test element (18’) at the bioreactor vessel (3), and / or the concentration of dissolved oxygen, preferably from a dissolved oxygen test element (18”) at the bioreactor vessel (3), of the content of the bioreactor vessel (3).

5. Mobile bioprocessing module (1) according to any one of claims 1 to 4, c h a r a c t e r i z e d b y a temperature control device (20) for controlling the temperature of the bioreactor vessel (3), and in that, preferably, the temperature control device (20) is configured to at least partially, in particular entirely, encompass the bioreactor vessel (3), the temperature control device (20) comprises one or more heating elements (30) for heating the bioreactor vessel (3) and / or the area encompassed by the temperature control device (20), the temperature control device (20) comprises one or more temperature sensors (31) for detecting the temperature of the bioreactor vessel (3) and / or the area encompassed by the temperature control device (20), and / or the temperature control device (20) comprises one or more air circulation devices (32), preferably fans, for circulating air around the bioreactor vessel (3) and / or inside the area encompassed by the temperature control device (20).

6. Mobile bioprocessing module (1) according to any one of claims 1 to 5, c h a r a c t e r i z e d i n t h a t the control device (5) is configured to control and / or to communicate with the bioreactor vessel (3), the sampling device (16), the module imaging device (15), the culture medium vessel (7), the waste vessel (9), the wash buffer vessel, the reagent vessel, the pressure sensor (21), the power storagedevice (29), the agitation device (4) and / or the temperature control device (20), preferably for controlling the bioprocess performed by the mobile bioprocessing module (1).

7. Bioprocessing unit (34) for performing a bioprocess comprising: at least one workstation (37) for performing a work operation, preferably a bioprocess, multiple storage locations (35) for respectively storing at least one mobile bioprocessing module (1) for performing a bioprocess, preferably at least one mobile bioprocessing module (1) according to any one of claims 1 to 6, and a control unit (38), c h a r a c t e r i z e d i n t h a t at least one, preferably each, storage location (35) of the multiple storage locations (35) and / or the workstation (37) respectively comprises at least one unit interface section (52) for detachably connecting the respective mobile bioprocessing module (1) to the bioprocessing unit (34), preferably to the respective storage location (35) and / or workstation (37), and in that the respective unit interface section (52) of the at least one, preferably each, storage location (35) and / or of the workstation (37) comprises, preferably consists of, at least one unit power interface (53) for transmitting power to the respectively connected mobile bioprocessing module (1), at least one unit data interface (54) for transmitting data to and / or receiving data from the respectively connected mobile bioprocessing module (1) and / or at least one unit gas interface (55) for transferring gas to and / or receiving gas from the respectively connected mobile bioprocessing module (1J-8. Bioprocessing unit (34) according to claim 7, c h a r a c t e r i z e d i n t h a t the unit power interface (53) comprises a unit power connector (56) for mating with a module power interface (23), preferably of the respectivelyconnected bioprocessing module (1), the unit power interface (53) is designed for contactless transfer of power, preferably to the respectively connected bioprocessing module (1), the unit data interface (54) comprises a unit data connector (57) for mating with a module data interface (24), preferably of the respectively connected bioprocessing module (1), the unit data interface (54) is designed for contactless reception and / or transmission of data, preferably from and / or to the respectively connected bioprocessing module (1), and / or the unit gas interface (55) comprises a unit gas connector (58) for mating with a module gas interface (25), preferably of the respectively connected bioprocessing module (1), that the respective unit power interface (53), preferably unit power connector (56), comprises a spring-loaded pin connector for mating with a receptacle, preferably of the respectively connected bioprocessing module (1) and / or respectively connected module power interface (23), preferably module power connector (26), that the respective unit power interface (53), preferably unit power connector (56), comprises a receptacle for mating with a spring-loaded pin connector, preferably of the respectively connected bioprocessing module (1) and / or respectively connected module power interface (23), preferably module power connector (26), that the respective unit data interface (54), preferably unit data connector (57), comprises a spring-loaded pin connector for mating with a receptacle, preferably of the respectively connected bioprocessing module (1) and / or respectively connected module data interface (24), preferably module data connector (27), that the respective unit data interface (54), preferably unit data connector (57), comprises a receptacle for mating with a spring-loaded pin connector, preferably of the respectively connected bioprocessing module (1) and / or respectively connected module data interface (24), preferably module data connector (27),that the respective unit data interface [54], preferably unit data connector (57), comprises a, preferably optical, unit data connection interface (73) for mating and / or interacting with an optical interface, preferably of the respectively connected bioprocessing module (1) and / or respectively connected module data interface (24), preferably module data connector (27), and / or that the respective unit gas interface (55), preferably unit gas connector (58), comprises a male and / or female unit gas connection interface for mating with a module gas connection interface (25), preferably of the respectively connected bioprocessing module (1) and / or respectively connected module gas interface (25), in particular module gas connector (28).

9. Bioprocessing unit (34) according to claim 7 or claim 8, c h a r a c t e r i z e d b y a pH-monitoring unit (59) for determining and / or controlling the pH value in a respective bioreactor vessel (3) of at least one, preferably each, connected mobile bioprocessing module (1), a dissolved-oxygen-monitoring unit (60) for determining and / or controlling the concentration of dissolved oxygen in a respective bioreactor vessel (3) of at least one, preferably each, connected mobile bioprocessing module (1), a metabolite-monitoring unit (61) for determining the concentration of at least one metabolite in a respective bioreactor vessel (3) of at least one, preferably each, connected mobile bioprocessing module (1), a unit imaging device (62) for imaging, optical sampling and / or optically determining the content, preferably the cell count, viability and / or size distribution of the cell culture, of a bioreactor vessel (3) of at least one, preferably each, connected mobile bioprocessing module (1), and / or a gas supply unit (63) for supplying gas to a respective bioreactor vessel (3) of at least one, preferably each, connected mobile bioprocessing module (1), preferably via the respective unit gas interface (55), in particular unit gas connector (58).

10. Bioprocessing unit ( 34] according to claim 9, c h a r a c t e r i z e d i n t h a t the gas supply unit (63) comprises for at least one, preferably each, storage location (35) of the multiple storage locations [35] and / or for the workstation (37) respectively at least one, preferably at least three, primary gas conduits (64) for respectively transferring at least one gas, and in that, preferably, for at least one, preferably each, storage location (35) of the multiple storage locations (35) and / or for the workstation (37) a mass flow controller (65) is provided at each respective primary gas conduit (64) for metering gas in the respective primary gas conduit (64), a non-return valve (66) is provided at the output of each respective mass flow controller (65), the respective primary gas conduits (64) are merged into a secondary gas conduit (67), connected to the unit gas interface (55), preferably unit gas connector (58), of the respective storage location (35) and / or workstation (37), and / or a pressure relief valve (68) is provided at the respective secondary gas conduit (67).

11. Bioprocessing unit (34) according to any one of claims 7 to 10, c h a r a c t e r i z e d i n t h a t at least one, preferably each, storage location (35) of the multiple storage locations (35) comprises respectively at least one fixing device (69) for fixing the respective mobile bioprocessing module (1) to and / or for preventing the unintended discharge of the respective mobile bioprocessing module (1) from the respective storage location (35) and in that, preferably, the fixing device (69) comprises a barrier, preferably arranged at the bottom of the receiving chamber (71) of the respective storage location, for reducing the height of the free space of the respective storage location (35) at least in sections,the fixing device (69) comprises at least one fixing element (70) which fixing element (70) is moveable between a fixing position for fixing the respective mobile bioprocessing module (1) and a release position for releasing the respective mobile bioprocessing module (1), and / or the fixing element (70) is designed to be normally closed in the fixing position.

12. Bioprocessing unit (34) according to any one of claims 7 to 11, c h a r a c t e r i z e d b y at least one, preferably optical, scanner (49) for scanning a primaiy identifier (12), preferably machine readable medium, in particular barcode, of the mobile bioprocessing module (1) and, preferably, the control unit (38) is configured to prevent performing a bioprocess by the workstation (37) on the mobile bioprocessing module (1) provided in the workstation (37) and / or to issue an alert when a primaiy identifier (12) of the mobile bioprocessing module (1) provided in the workstation (37) does not match an expected primary identifier (12).

13. Bioprocessing unit (34) according to any one of claims 7 to 12, c h a r a c t e r i z e d i n t h a t the control unit (38) is configured for detecting, preferably via the unit power interface (53) and / or the unit data interface (54), if the mobile bioprocessing module (1) is connected to a respective storage location (35) of the multiple storage locations (35), that the control unit (38) is configured for actuating the respective fixing element (70) of at least one, preferably each, storage location (35) of the multiple storage locations (35) if the connection of the mobile bioprocessing module (1) to the respective storage location (35) is detected by the control unit (38), and / or that the control unit (38) is configured for initiating the transfer of power, data and / or gas, preferably via the unit power interface (53), the unit datainterface (54) and / or the unit gas interface (55), to the mobile bioprocessing module (1) if the fixation of the respective mobile bioprocessing module (1) via the fixing device (70) of the respective storage location (35) of the multiple storage locations (35) is detected by the control unit.

14. Bioprocessing unit (34) according to any one of claims 7 to 13, c h a r a c t e r i z e d i n t h a t at least one, preferably each, storage location (35) of the multiple storage locations (35) comprises a receiving chamber (71) for receiving a respective mobile bioprocessing module (1), that at least one, preferably each, storage location (35) of the multiple storage locations (35) comprises at least one, preferably at least two, in particular oppositely arranged, guiding element (72) for guiding a respective mobile bioprocessing module (1) in the respective storage location (35), preferably in the receiving chamber (71) of the respective storage location (35), that at least one, preferably each, storage location (35) of the multiple storage locations (35) comprises a stop element (74), preferably adjacent to an open end (76) of the respective receiving chamber (71), for preventing a mobile bioprocessing module (1) slipping out of the respective storage location (35), and / or that the multiple storage locations (35) are stacked on one another.

15. Bioprocessing unit (34) according to any one of claims 7 to 14, c h a r a c t e r i z e d b y a handling device (50) for moving, preferably lifting, the mobile bioprocessing module (1), preferably within a unit housing (39) of the bioprocessing unit (34), and in that, preferably, the handling device (50) comprises a at least one fork element and / or at least one support tray (51) for supporting a bioprocessing module (1) during the movement, preferably lifting, by the handling device (50),the handling device (50) is configured for moving, preferably lifting, the mobile bioprocessing module (1) to a storage location (35) of the multiple storage locations (35), to the workstation (37), between different storage locations (35) of the multiple storage locations (35) and / or between the workstation (37) and a storage location (35) of the multiple storage locations (35), and / or the handling device (50) is configured to support the mobile bioprocessing module (1) in the workstation (37), preferably while at least one of the work operations and / or at least on step of the bioprocess is performed on the mobile bioprocessing module (1).

16. Bioprocessing unit (34) according to any one of claims 7 to 15, c h a r a c t e r i z e d i n t h a t the workstation (37) comprises one or more cartridge support sections (41) for supporting one or more cartridges (42), one or more active elements (45) for interacting with, preferably performing a work operation on, the mobile bioprocessing module (1) and / or the one or more cartridges (42) arranged in the workstation (37), and / or one or more connection devices (46), preferably for aseptically connecting and / or disconnecting the one or more cartridges (42) and the mobile bioprocessing module (1) arranged in the workstation, and in that, preferably, the one or more active elements (45) are configured for adding and / or removing at least one substance from a respective bioreactor vessel (3) of the respective mobile bioprocessing module (1) arranged in the workstation (37), the one or more active elements (45) are configured for retrieving at least one sample and / or for processing at least one sample from a respective bioreactor vessel (3) of the respective mobile bioprocessing module (1) arranged in the workstation (37), and / or the one or more connection devices (46) are configured for connecting, preferably welding, at least one tube (47) of the mobile bioprocessing module (1) and / or the one or more cartridges (42) arranged in the workstation (37).

17. Bioprocessing unit according to any one of claims 7 to 16, c h a r a c t e r i z e d i n t h a t the workstation [37] comprises one or more work positions [48] for performing a work operation on the respective mobile bioprocessing module (1) and / or the one or more cartridges (42) arranged in the workstation (37), preferably the one or more work positions (48), and in that, preferably, the one or more work positions (48) comprise a refill location for refilling, preferably using the one or more active elements (45) and / or a respective culture medium vessel (7), wash buffer vessel and / or reagent vessel of the respective mobile bioprocessing module (1) arranged in the refill location, the one or more work positions (48) comprise an emptying location for emptying, preferably using the one or more active elements (45) and / or a waste vessel (9) of the respective mobile bioprocessing module (1) arranged in the emptying location, and / or the one or more work positions (48) comprise a swapping location for swapping, preferably using the one or more active elements (45) and / or a respective bioreactor vessel (3), culture medium vessel (7), wash buffer vessel, reagent vessel and / or waste vessel (9) of the respective mobile bioprocessing module (1) arranged in the swapping location.

18. Bioprocessing unit (34) according to any one of claims 7 to 17, c h a r a c t e r i z e d b y at least one, preferably multiple, air circulation devices (75) for removing heat from at least one, preferably each, of the multiple storage locations (35), and in that, the at least one, preferably multiple, air circulation devices (75) are stacked on one another and / or provided along the stacked storage locations (35), and / orthe at least one, preferably multiple, air circulation devices (75) are provided between the multiple storage locations (35) and an open space in the bioprocessing unit (34).

19. Bioprocessing system (36) for performing a bioprocess comprising: a bioprocessing unit (34) according to any one of claims 7 to 18, and one or more mobile bioprocessing modules (1) according to any one of claims 1 to 6 for detachable connection with the bioprocessing unit (34).

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