Gel composition and oil-in-water composition

Abstract

The present invention provides a gel composition and an oil-in-water composition that have a strong barrier function.　The gel composition comprises: one or more first compounds, which are represented by polyoxyethylene phytosterols; one or more second compounds, which are represented by polyethylene glycol distearate; one or more third compounds, which are represented by polyoxyethylene alkyl ethers; and one or more fourth compounds selected from the group consisting of ascorbic acid and salts thereof, ascorbic acid monoesters, ascorbic acid diesters, tocopherols and esters thereof, glycyrrhetinic acid and esters and salts thereof, and betamethasone and esters thereof.

Description

Gel compositions and oil-in-water compositions

[0001] The present disclosure relates to a gel composition. The present disclosure also relates to an oil-in-water composition comprising the gel composition.

[0002] An α-gel composition that can be used as a skin topical agent and an emulsifier is known (see, for example, Patent Document 1).

[0003] The α-gel composition described in Patent Document 1 is composed of polyoxyethylene (6 mol) distearate, polyoxyethylene (10 mol) behenyl ether, and polyoxyethylene (10 mol) phytosterol.

[0004] JP 2017-132765 A

[0005] The following analysis is given in light of the present disclosure.

[0006] The stratum corneum is composed of cornified cells and intercellular lipids present between the cornified cells. The intercellular lipids have a lamellar structure composed of ceramides, fatty acids, cholesterol, etc. The intercellular lipids are thought to have the functions of arranging the cornified cells, protecting the skin from external stimuli, and suppressing moisture evaporation from the skin (barrier function).

[0007] If a topical skin preparation such as a cosmetic contains a component with barrier function, such as intercellular lipids, the topical skin preparation can exhibit a strong barrier function. For example, the α-gel composition described in Patent Document 1 does not contain any components related to intercellular lipids, and therefore cannot exhibit a strong barrier function.

[0008] Therefore, there is a demand for compositions with strong barrier function. Furthermore, it is preferable that such compositions with strong barrier function provide beneficial effects on the skin (e.g., moisturizing effect, firming effect, whitening effect, antioxidant effect, anti-inflammatory effect, anti-wrinkle effect, anti-blemish effect, etc.).

[0009] The present invention that achieves the above object is as follows.

[0010] Aspect 1: A gel composition containing the following compounds: one or more first compounds represented by the following formula I, one or more second compounds represented by the following formula II, one or more third compounds represented by the following formula III, and one or more fourth compounds selected from the group consisting of ascorbic acid and salts thereof, ascorbic acid monoesters, ascorbic acid diesters, tocopherol and esters thereof, glycyrrhetinic acid and esters and salts thereof, and betamethasone and esters thereof: (In Formula I, R １ is at least one selected from the group consisting of a steroid skeleton and a cholesterol skeleton, and R ２ is an alkylene group having 2 to 4 carbon atoms, and m is an integer of 5 to 30. (In Formula II, R ３ is a linear acyl group or a linear alkyl group having 16 to 24 carbon atoms, and R ４ is an alkylene group having 2 to 4 carbon atoms, and R ５ is a linear acyl group or a linear alkyl group having 16 to 24 carbon atoms, and n is an integer of 4 to 8. (In Formula III, R ６ is a linear acyl group or a linear alkyl group having 16 to 24 carbon atoms, and R ７is an alkylene group having 2 to 4 carbon atoms, and p is an integer of 5 to 30.) <Aspect 2> The gel composition according to Aspect 1, wherein the first compound, the second compound, the third compound, and the fourth compound form a lamellar gel phase. <Aspect 3> The gel composition according to Aspect 1 or 2, wherein the X-ray scattering pattern has a peak indicating a hexagonal crystal structure. <Aspect 4> The gel composition according to any one of Aspects 1 to 3, wherein, relative to 100 parts by mass of the total of the first compound, the second compound, and the third compound, the first compound is 49 parts by mass to 88 parts by mass, the second compound is 6 parts by mass to 23 parts by mass, the third compound is 6 parts by mass to 28 parts by mass, and the fourth compound is 3 parts by mass to 35 parts by mass. <Aspect 5> The gel composition according to any one of Aspects 1 to 4, further comprising water. <Aspect 6> The gel composition according to any one of Aspects 1 to 5, further comprising one or more fifth compounds selected from the group consisting of γ-oryzanol, phytosterol, cholesterol, ceramide, lecithin, and stearic acid. <Aspect 7> The gel composition according to any one of Aspects 1 to 6, which is a cosmetic. <Aspect 8> An oil-in-water composition comprising the gel composition according to any one of Aspects 1 to 6 and an oily component, wherein at least a portion of the oily component is coated on the gel composition as oil droplets. <Aspect 9> The oil-in-water composition according to Aspect 8, which is a cosmetic.

[0011] The gel composition of the present disclosure has a similar structure to human intercellular lipids due to a group of components similar to these lipids, and as a result, when the gel composition of the present disclosure is applied to the skin, it can provide a strong barrier function similar to that of human intercellular lipids.

[0012] Furthermore, the fourth compound contained in the gel composition of the present disclosure is a component that provides beneficial effects to the skin (e.g., moisturizing effect, firming effect, whitening effect, antioxidant effect, anti-inflammatory effect, anti-wrinkle effect, or anti-blemish effect, etc.), and therefore, by including the fourth compound, the gel composition of the present disclosure can also exhibit the aforementioned beneficial effects.

[0013] Since the oil-in-water composition of the present disclosure contains the gel composition of the present disclosure, when the oil-in-water composition of the present disclosure is applied to the skin, it can provide a strong barrier function similar to that of human intercellular lipids. Furthermore, the oil-in-water composition of the present disclosure can have beneficial effects on the skin (e.g., moisturizing effect, firming effect, whitening effect, antioxidant effect, anti-inflammatory effect, anti-wrinkle effect, anti-blemish effect, etc.).

[0014] In a preferred embodiment, the gel composition of the present disclosure can coat oil droplets and be stably dispersed in water.

[0015] FIG. 1 is a small-angle / wide-angle X-ray scattering chart of the gel composition of Example 3. FIG. 2 is a differential scanning calorimetry chart of Example 3. FIG. 3 is a polarizing microscope photograph of Example 3. FIG. 4 is a small-angle / wide-angle X-ray scattering chart of the gel composition of Example 15. FIG. 5 is a differential scanning calorimetry chart of Example 15. FIG. 6 is a polarizing microscope photograph of Example 15. FIG. 7 is a small-angle / wide-angle X-ray scattering chart of the gel composition of Example 22. FIG. 8 is a differential scanning calorimetry chart of Example 22. FIG. 9 is a polarizing microscope photograph of Example 22. FIG. 10 is a graph showing the results of the hydroxyl radical (OH) inhibition ability of Example 23. FIG. 11 is a graph showing the results of the lipid peroxide production rate of Example 23 and Comparative Example 1. FIG. 12 is a graph showing the results of the evaluation of stratum corneum protein carbonylation inhibition of Example 23 and Comparative Examples 1 and 2.

[0016] DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described in detail below with reference to the preferred embodiments. However, the present invention is not limited to the following embodiments, and various modifications can be made within the scope of the present invention.

[0017] In the following description, PEG is an abbreviation for polyethylene glycol, POE is an abbreviation for polyoxyethylene, and POP is an abbreviation for polyoxypropylene, and the number in parentheses after PEG, POE, or POP represents the average number of moles of PEG, POE, or POP groups added in the compound.

[0018] In the present disclosure, "plurality" may refer to a number of 2 or more, or 3 or more. The upper limit of the number of plurality is not particularly limited, and may be, for example, 30 or less, 20 or less, 10 or less, 8 or less, or 5 or less.

[0019] First Embodiment A gel composition according to a first embodiment of the present disclosure contains one or more first compounds represented by the following formula I, one or more second compounds represented by the following formula II, one or more third compounds represented by the following formula III, and one or more fourth compounds selected from the group consisting of ascorbic acid and salts thereof, ascorbic acid monoesters, ascorbic acid diesters, tocopherol and esters thereof, glycyrrhetinic acid and esters and salts thereof, and betamethasone and esters thereof.

[0020] The gel composition of the present disclosure is a composition containing a group of components that are partially or completely different from the group of components contained in intercellular lipids present in the skin, and preferably is a composition in which the group of components forms a lamellar structure (lamellar gel phase) similar to that of intercellular lipids. The gel composition of the present disclosure can also be referred to as a "pseudo-intercellular lipid." In the gel composition of the present disclosure, the lamellar gel phase more preferably has an α-type structure (hexagonal crystal structure).

[0021] In this disclosure, the term "lamellar gel phase" refers to a gel-like substance formed by an association of lamellar bilayer membranes formed by the components of a gel composition in the presence of water. In this disclosure, the term "α-gel" refers to a substance having a lamellar gel phase with at least a partial α-structure (hexagonal crystal structure). However, generally, a gel that is an association formed by a higher aliphatic alcohol and a hydrophilic surfactant in water and has an α-structure ("Physical Chemistry of Cetyl Alcohol," by Shoji Fukushima, Fragrance Journal Co., Ltd.) is referred to as a lamellar gel.

[0022] The formation of the lamellar gel phase can be confirmed by analyzing the X-ray scattering pattern. For example, if multiple peaks corresponding to the long spacings are obtained in the small angle region, it can be determined that the lamellar gel phase has been formed.

[0023] The formation of the α-type structure (hexagonal crystal structure) can be confirmed by analyzing the X-ray scattering pattern. For example, in addition to the presence of the lamellar gel phase, the X-ray scattering pattern in the wide-angle region (scattering vector q = 1.5 nm) －１When the presence of a peak in the vicinity of α-type structure (hexagonal crystal structure) can be confirmed, it can be determined that an α-type structure (hexagonal crystal structure) is formed.

[0024] Without being limited by theory, the mechanism by which a gel composition is obtained using the first to fourth compounds according to the present disclosure is presumed to be as follows.

[0025] That is, a gel composition comprising one or more first compounds represented by Formula I below, one or more second compounds represented by Formula II below, and one or more third compounds represented by Formula III below is a composition containing components that are partially or completely different from the components contained in intercellular lipids present in skin, and preferably, the components form a lamellar structure (lamellar gel phase) similar to that of intercellular lipids. In this gel composition, a fourth compound selected from the group consisting of ascorbic acid and salts thereof, ascorbic acid monoesters, ascorbic acid diesters, tocopherol and esters thereof, glycyrrhetinic acid and esters and salts thereof, and betamethasone and esters thereof is structurally similar to at least one of the first to third compounds, and therefore can be added to or partially replace at least one of the first to third compounds. More specifically, for example, ascorbic acid and salts thereof, and ascorbic acid monoesters can be substituted for the third compound among the first to third compounds. Additionally, an ascorbic acid diester may be substituted for the second compound among the first to third compounds. Additionally, tocopherol and its esters, glycyrrhetinic acid and its esters and salts, and betamethasone and its esters may be substituted for the first compound (having a steroid skeleton and a cholesterol skeleton) among the first to third compounds.

[0026] Thus, as a result of the substitution of at least one of the first to third compounds with the fourth compound, the composition including the first to fourth compounds can form a gel composition, and it is speculated that the fourth compound can form a lamellar gel structure with the first, second, and third compounds.

[0027] [First Compound] The first compound may be a compound represented by the following formula I: In formula I, R １ is at least one selected from the group consisting of a steroid skeleton and a cholesterol skeleton. １ R may be at least one moiety other than a hydroxy group selected from the group consisting of phytosterol, cholesterol, and ergosterol. ２ is an alkylene group having 2 to 4 carbon atoms. m is an integer of 5 or more, or 10 or more. m is an integer of 30 or less, or 20 or less.

[0028]

[0029] Specific examples of the first compound include polyoxyethylene (5 mol) phytosterol (e.g., Nikkol BPS-5, manufactured by Nikko Chemicals Co., Ltd.), polyoxyethylene (10 mol) phytosterol (e.g., Nikkol BPS-10, manufactured by Nikko Chemicals Co., Ltd.), polyoxyethylene (20 mol) phytosterol (e.g., Nikkol BPS-20, manufactured by Nikko Chemicals Co., Ltd.), polyoxyethylene (30 mol) phytosterol (e.g., Nikkol BPS-30, manufactured by Nikko Chemicals Co., Ltd.), and polyoxyethylene (10 mol) cholesterol (e.g., Emalex CS-10, manufactured by Nippon Emulsion Co., Ltd.).

[0030] In the gel composition of the present disclosure, the content of the first compound is not particularly limited, and may be defined as follows, for example.

[0031] The first compound may be 49 parts by mass or more, 50 parts by mass or more, 51 parts by mass or more, 52 parts by mass or more, 53 parts by mass or more, 54 parts by mass or more, 55 parts by mass or more, 56 parts by mass or more, 57 parts by mass or more, 58 parts by mass or more, 59 parts by mass or more, 60 parts by mass or more, 61 parts by mass or more, 62 parts by mass or more, 63 parts by mass or more, 64 parts by mass or more, or 65 parts by mass or more, based on 100 parts by mass of the total of the first compound, the second compound, and the third compound. 87 parts by mass or less, 86 parts by mass or less, 85 parts by mass or less, 84 parts by mass or less, 83 parts by mass or less, 82 parts by mass or less, 81 parts by mass or less, 80 parts by mass or less, 79 parts by mass or less, 78 parts by mass or less, 77 parts by mass or less, 76 parts by mass or less 75 parts by weight or less, 74 parts by weight or less, 73 parts by weight or less, 72 parts by weight or less, 71 parts by weight or less, 70 parts by weight or less, 69 parts by weight or less, 68 parts by weight or less, 67 parts by weight or less, 66 parts by weight or less, or 65 parts by weight or less.

[0032] The content of the first compound may be, for example, 2% by mass or more, 5% by mass or more, 10% by mass or more, 15% by mass or more, 20% by mass or more, 23% by mass or more, 30% by mass or more, or 35% by mass or more, relative to the total mass of the gel composition. The content of the first compound may be, for example, 50% by mass or less, 45% by mass or less, 35% by mass or less, 30% by mass or less, 25% by mass or less, or 20% by mass or less, relative to the total mass of the gel composition.

[0033] [Second Compound] The second compound may be a compound represented by the following formula II: In formula II, R ３ is a linear acyl group or a linear alkyl group having 16 to 24 carbon atoms. ４ is an alkylene group having 2 to 4 carbon atoms. ５ is a linear acyl group or a linear alkyl group having 16 to 24 carbon atoms. n is an integer of 4 to 8.

[0034]

[0035] Examples of the second compound include polyoxyethylene (4 mol) distearate (e.g., Emalex 200DIS, manufactured by Nippon Emulsion Co., Ltd.), polyoxyethylene (6 mol) distearate (e.g., Emalex 300DIS, manufactured by Nippon Emulsion Co., Ltd.), polyoxyethylene (8 mol) distearate (e.g., Emalex 400DIS, manufactured by Nippon Emulsion Co., Ltd.), steareth-4 stearate (e.g., Emalex SWS-4, manufactured by Nippon Emulsion Co., Ltd.), steareth-6 stearate (e.g., Emalex SWS-6, manufactured by Nippon Emulsion Co., Ltd.), and polyoxyethylene (8 mol) dibehenyl ether. The bonding mode between the polyoxyethylene chain and the alkyl group may be either an ester or an ether, or may include both.

[0036] In the gel composition of the present disclosure, the content of the second compound is not particularly limited, and may be defined as follows, for example.

[0037] The second compound may be 6 parts by mass or more, 7 parts by mass or more, 8 parts by mass or more, 9 parts by mass or more, 10 parts by mass or more, 11 parts by mass or more, 12 parts by mass or more, 13 parts by mass or more, 14 parts by mass or more, 15 parts by mass or more, 16 parts by mass or more, 17 parts by mass or more, 18 parts by mass or more, 19 parts by mass or more, or 20 parts by mass or more, relative to 100 parts by mass of the total of the first compound, the second compound, and the third compound, and may be 23 parts by mass or less, 22 parts by mass or less, 21 parts by mass or less, 20 parts by mass or less, 19 parts by mass or less, 18 parts by mass or less, 17 parts by mass or less, 16 parts by mass or less, or 15 parts by mass or less.

[0038] The content of the second compound may be, for example, 0.1% by mass or more, 0.5% by mass or more, 1% by mass or more, 2% by mass or more, 3% by mass or more, 4% by mass or more, 5% by mass or more, 6% by mass or more, or 7% by mass or more, relative to the total mass of the gel composition, and may be, for example, 20% by mass or less, 16% by mass or less, 12% by mass or less, 10% by mass or less, 8% by mass or less, or 6% by mass or less, relative to the total mass of the gel composition.

[0039] [Third Compound] The third compound may be a compound represented by the following formula III: In formula III, R６ is a linear acyl group or a linear alkyl group having 16 to 24 carbon atoms. ７ is an alkylene group having 2 to 4 carbon atoms. p is an integer of 5 or more, or 10 or more. In addition, p is an integer of 30 or less, or 20 or less.

[0040]

[0041] Examples of the third compound include polyoxyethylene (10 mol) behenyl ether (e.g., Nikkol BB-10, manufactured by Nikko Chemicals Co., Ltd.), polyoxyethylene (20 mol) behenyl ether (e.g., Nikkol BB-20, manufactured by Nikko Chemicals Co., Ltd.), polyoxyethylene (30 mol) behenyl ether (e.g., Nikkol BB30, manufactured by Nikko Chemicals Co., Ltd.), polyoxyethylene (7 mol) cetyl ether (e.g., Emalex 107, manufactured by Nippon Emulsion Co., Ltd.), and polyoxyethylene (10 mol) stearyl ether (e.g., Emalex 610, manufactured by Nippon Emulsion Co., Ltd.).

[0042] In the gel composition of the present disclosure, the content of the third compound is not particularly limited, and may be defined as follows, for example.

[0043] The third compound may be 6 parts by mass or more, 7 parts by mass or more, 8 parts by mass or more, 9 parts by mass or more, 10 parts by mass or more, 11 parts by mass or more, 12 parts by mass or more, 13 parts by mass or more, 14 parts by mass or more, 15 parts by mass or more, 16 parts by mass or more, 17 parts by mass or more, 18 parts by mass or more, 19 parts by mass or more, or 20 parts by mass or more, relative to 100 parts by mass of the total of the first compound, the second compound, and the third compound, and may be 28 parts by mass or less, 27 parts by mass or less, 26 parts by mass or less, 25 parts by mass or less, 24 parts by mass or less, 23 parts by mass or less, 22 parts by mass or less, 21 parts by mass or less, 20 parts by mass or less, 19 parts by mass or less, 18 parts by mass or less, 17 parts by mass or less, 16 parts by mass or less, or 15 parts by mass or less.

[0044] The content of the third compound may be, for example, 0.1% by mass or more, 0.5% by mass or more, 1% by mass or more, 2% by mass or more, 3% by mass or more, 4% by mass or more, 5% by mass or more, 6% by mass or more, or 7% by mass or more, relative to the total mass of the gel composition, and may be, for example, 20% by mass or less, 16% by mass or less, 12% by mass or less, 10% by mass or less, 8% by mass or less, or 6% by mass or less, relative to the total mass of the gel composition.

[0045] In the gel composition of the present disclosure, the total mass of the first compound, the second compound, and the third compound may be, for example, 29% by mass or more, 30% by mass or more, 31% by mass or more, 32% by mass or more, 33% by mass or more, 34% by mass or more, 35% by mass or more, 36% by mass or more, 37% by mass or more, 38% by mass or more, 39% by mass or more, 40% by mass or more, 41% by mass or more, 42% by mass or more, 43% by mass or more, 44% by mass or more, 45% by mass or more, 46% by mass or more, 47% by mass or more, 48% by mass or more, 49% by mass or more, or 50% by mass or more, relative to the total mass of the gel composition, and may be 66% by mass or less, 65% by mass or less, 64% by mass or less, 63% by mass or less, 62% by mass or less, 61% by mass or less, 60% by mass or less, 59% by mass or less, 58% by mass or less, 57% by mass or less, 56% by mass or less, or 55% by mass or less.

[0046] [Fourth Compound] The fourth compound may be selected from the group consisting of ascorbic acid and its salts, ascorbic acid monoesters, ascorbic acid diesters, tocopherol and its esters, glycyrrhetinic acid and its esters and salts, and betamethasone and its esters.

[0047] Ascorbic acid and its salts, ascorbic acid monoesters, and ascorbic acid diesters can have at least one of the following beneficial effects: antioxidant effect, skin-beautifying effect, whitening effect, and pigmentation-inhibiting effect.

[0048] As ascorbic acid, for example, L-ascorbic acid (also called "vitamin C") or D-ascorbic acid (also called "erythorbic acid") may be used.

[0049] The salt of ascorbic acid may be, for example, a physiologically acceptable salt. More specifically, examples of the salt of ascorbic acid include, but are not limited to, alkali metal salts such as sodium salt and potassium salt, alkaline earth metal salts such as calcium salt and magnesium salt, ammonium salt, organic amine salts such as triethylamine salt and triethanolamine salt, and basic amino acid salts such as lysine salt and arginine salt.

[0050] Examples of ascorbic acid monoesters include, but are not limited to, inorganic ascorbic acid monoesters such as L-ascorbic acid monophosphate and L-ascorbic acid-2-sulfate, and ascorbic acid monoalkyl esters such as L-ascorbic acid monostearate, L-ascorbic acid monopalmitate, and L-ascorbic acid monooleate.

[0051] Examples of ascorbic acid diesters include, but are not limited to, L-ascorbic acid distearate, L-ascorbic acid dipalmitate, and L-ascorbic acid dioleate.

[0052] Tocopherol and its esters can have at least one of the following beneficial effects: antioxidant effect, skin turnover promotion effect, and skin roughness prevention effect.

[0053] Examples of tocopherol that can be used include α-tocopherol, β-tocopherol, γ-tocopherol, and δ-tocopherol.

[0054] Examples of esters of tocopherol include, but are not limited to, tocopherol acetate, tocopherol nicotinate, tocopherol succinate, and tocopherol linoleate.

[0055] Glycyrrhetinic acid and its esters and salts may have beneficial effects such as at least an anti-inflammatory effect.

[0056] As the glycyrrhetinic acid, for example, β-glycyrrhetinic acid or α-glycyrrhetinic acid may be used.

[0057] Examples of glycyrrhetinic acid esters include, but are not limited to, glycerin glycyrrhetinate, stearyl glycyrrhetinate, pyridoxine glycyrrhetinate, and the like.

[0058] The salt of glycyrrhizinic acid may be, for example, physiologically acceptable salt.More specifically, the salt of glycyrrhizinic acid may include, but is not limited to, alkali metal salts such as sodium salt and potassium salt, alkaline earth metal salts such as calcium salt and magnesium salt, organic amine salts such as ammonium salt, triethylamine salt and triethanolamine salt, and basic amino acid salts such as lysine salt and arginine salt.

[0059] Betamethasone and its esters may have beneficial effects, such as at least an anti-inflammatory effect.

[0060] Examples of betamethasone esters include, but are not limited to, betamethasone acetate, betamethasone valerate, betamethasone benzoate, betamethasone dipropionate, and betamethasone sodium phosphate.

[0061] In the gel composition of the present disclosure, the content of the fourth compound is not particularly limited, and may be defined as follows, for example.

[0062] The fourth compound may be 3 parts by mass or more, 4 parts by mass or more, 5 parts by mass or more, 6 parts by mass or more, 7 parts by mass or more, 8 parts by mass or more, 9 parts by mass or more, 10 parts by mass or more, 11 parts by mass or more, 12 parts by mass or more, 13 parts by mass or more, 14 parts by mass or more, 15 parts by mass or more, 16 parts by mass or more, 17 parts by mass or more, 18 parts by mass or more, 19 parts by mass or more, or 20 parts by mass or more, relative to 100 parts by mass of the total of the first compound, the second compound, and the third compound, and may be 35 parts by mass or less, 34 parts by mass or less, 33 parts by mass or less, 32 parts by mass or less, 31 parts by mass or less, 30 parts by mass or less, 29 parts by mass or less, 28 parts by mass or less, 27 parts by mass or less, 26 parts by mass or less, 25 parts by mass or less, 24 parts by mass or less, 23 parts by mass or less, 22 parts by mass or less, 21 parts by mass or less, or 20 parts by mass or less.

[0063] Furthermore, the fourth compound may be, for example, 0.1% by mass or more, 0.5% by mass or more, 1% by mass or more, 2% by mass or more, 3% by mass or more, 4% by mass or more, 5% by mass or more, 6% by mass or more, 7% by mass or more, 8% by mass or more, 9% by mass or more, or 10% by mass or more, relative to the total mass of the gel composition, and may be 20% by mass or less, 16% by mass or less, 12% by mass or less, 10% by mass or less, 8% by mass or less, or 6% by mass or less.

[0064] In the gel composition of the present disclosure, the total mass of the first compound, the second compound, the third compound, and the fourth compound is, for example, 29% by mass or more, 30% by mass or more, 31% by mass or more, 32% by mass or more, 33% by mass or more, 34% by mass or more, 35% by mass or more, 36% by mass or more, 37% by mass or more, 38% by mass or more, 39% by mass or more, 40% by mass or more, 41% by mass or more, or 42% by mass or more relative to the total mass of the gel composition. , 43% by mass or more, 44% by mass or more, 45% by mass or more, 46% by mass or more, 47% by mass or more, 48% by mass or more, 49% by mass or more, or 50% by mass or more, and may be 66% by mass or less, 65% by mass or less, 64% by mass or less, 63% by mass or less, 62% by mass or less, 61% by mass or less, 60% by mass or less, 59% by mass or less, 58% by mass or less, 57% by mass or less, 56% by mass or less, or 55% by mass or less.

[0065] [Water] The gel composition of the present disclosure may further contain water. The water content may be, for example, 10% by mass or more, 15% by mass or more, 20% by mass or more, 25% by mass or more, 30% by mass or more, 35% by mass or more, or 40% by mass or more, based on the total mass of the gel composition. The water content may be, for example, 60% by mass or less, 55% by mass or less, 50% by mass or less, 45% by mass or less, 40% by mass or less, or 35% by mass or less, based on the total mass of the gel composition.

[0066] The gel composition according to the first embodiment can exert a skin barrier function when applied to the skin, for example, it can suppress water evaporation from inside the skin (occlusion).

[0067] The gel composition according to the first embodiment has a high barrier function.

[0068] The gel composition according to the first embodiment can coat oil droplets and stably disperse them in water.

[0069] In the gel composition according to the first embodiment, the first compound, the second compound, the third compound, and the fourth compound may be in a form that forms a lamellar gel phase.

[0070] Furthermore, the gel composition according to the first embodiment can have a peak indicative of a hexagonal crystal structure in the X-ray scattering pattern.

[0071] Furthermore, the gel composition according to the first embodiment can be a functional gel composition by including the fourth compound described above. For example, the gel composition of the present disclosure can be an antioxidant gel composition, an anti-inflammatory gel composition, a moisturizing gel composition, a firming gel composition, a whitening gel composition, an anti-wrinkle gel composition, or an anti-stain gel composition. Of course, the gel composition of the present disclosure may have multiple of the above functions.

[0072] Second Embodiment A gel composition according to a second embodiment of the present disclosure can further contain a fifth compound in addition to the components in the gel composition according to the first embodiment.

[0073] Fifth Compound The gel compositions of the present disclosure may further comprise one or more fifth compounds.

[0074] Here, the fifth compound can be selected from the group consisting of ceramide, lecithin, γ-oryzanol, phytosterol, cholesterol, and stearic acid.

[0075] The fifth compound may be a two-chain amphiphilic substance having a nitrogen atom. In the present disclosure, "two-chain" refers to an amphiphilic substance having two carbon chains, preferably hydrocarbon chains having 5 to 24 carbon atoms. The hydrocarbon chains may be saturated or unsaturated. The hydrocarbon chains are preferably linear. The amphiphilic substance is a substance having a hydrophilic portion and a hydrophobic portion. Examples of such a fifth compound include at least one selected from the group consisting of ceramide and lecithin.

[0076] The ceramide may be a natural ceramide or a synthetic ceramide. The synthetic ceramide may have the same structure as the natural ceramide or may have a similar structure. The ceramide is preferably capable of forming a lamellar gel structure with at least the first compound, the second compound, the third compound, and the fourth compound. The ceramide is preferably a human ceramide. The ceramide is more preferably at least one selected from the group consisting of ceramide 1, ceramide 2, ceramide 3, ceramide 3B, ceramide 5, and ceramide 6.

[0077] The lecithin may be, for example, at least one selected from the group consisting of soybean lecithin, egg yolk lecithin, and hydrogenated lecithin. The lecithin may be phosphatidylcholine.

[0078] The fifth compound may be a compound having a steroid skeleton (cyclopentanohydrophenanthrene ring), and examples of such a fifth compound include at least one selected from the group consisting of phytosterol, cholesterol, and oryzanol (γ-oryzanol).

[0079] Furthermore, the fifth compound may be at least one selected from the group consisting of higher fatty acids having 14 to 22 carbon atoms. An example of such a fifth compound is stearic acid.

[0080] In the gel composition of the present disclosure, when the fifth compound is contained, the content thereof is not particularly limited, and may be specified, for example, as follows.

[0081] The fifth compound may be, for example, 1 part by mass or more, 2 parts by mass or more, 3 parts by mass or more, 4 parts by mass or more, 5 parts by mass or more, 6 parts by mass or more, 7 parts by mass or more, 8 parts by mass or more, 9 parts by mass or more, 10 parts by mass or more, 15 parts by mass or more, or 20 parts by mass or more, relative to 100 parts by mass of the total of the first compound, the second compound, and the third compound in the gel composition, and may be 30 parts by mass or less, 25 parts by mass or less, 22 parts by mass or less, 20 parts by mass or less, 18 parts by mass or less, 15 parts by mass or less, or 10 parts by mass or less.

[0082] The content of the fifth compound may be, for example, 0.1% by mass or more, 0.5% by mass or more, 1% by mass or more, 2% by mass or more, 3% by mass or more, 4% by mass or more, or 5% by mass or more relative to the total mass of the gel composition, and may be, for example, 20% by mass or less, 16% by mass or less, 12% by mass or less, 10% by mass or less, 8% by mass or less, or 6% by mass or less relative to the total mass of the gel composition.

[0083] In the gel composition of the present disclosure, the first compound, the second compound, the third compound, the fourth compound, and the fifth compound preferably form a lamellar gel phase in the gel composition.

[0084] In the second embodiment, the description in the first embodiment is incorporated with respect to the components other than the fifth compound.

[0085] The gel composition according to the second embodiment can obtain the same effects as those of the first embodiment. According to the second embodiment, the stability of the gel composition can be improved more than that of the first embodiment.

[0086] [Third embodiment] An oil-in-water composition according to a third embodiment of the present disclosure comprises the gel composition according to at least one of the first and second embodiments and an oil component. The oil component in the third embodiment does not include the first to fifth compounds described above.

[0087] At least a portion of the oily component is coated with the gel composition. The oily component exists as oil droplets and can be emulsified by the gel composition. In other words, the gel composition of the present disclosure can function as an emulsifier and can be an emulsifier.

[0088] The average particle size of the oily component (i.e., the average particle size of the oil droplets) can be, for example, 0.5 μm or more, and the average particle size of the oily component can be, for example, 10 μm or less.

[0089] In the oil-in-water composition of the present disclosure, the content of the first compound is not particularly limited, and may be, for example, 0.001% by mass or more, 0.005% by mass or more, 0.01% by mass or more, 0.05% by mass or more, or 0.1% by mass or more, and may be 98% by mass or less, 96% by mass or less, 94% by mass or less, 90% by mass or less, or 88% by mass or less, relative to the entire oil-in-water composition.

[0090] In the oil-in-water composition of the present disclosure, the content of the second compound is not particularly limited, and may be, for example, 0.001% by mass or more, 0.005% by mass or more, 0.01% by mass or more, 0.05% by mass or more, or 0.1% by mass or more, relative to the entire oil-in-water composition, and may be 43% by mass or less, 38% by mass or less, 33% by mass or less, 28% by mass or less, or 23% by mass or less.

[0091] In the oil-in-water composition of the present disclosure, the content of the third compound is not particularly limited, and may be, for example, 0.001% by mass or more, 0.005% by mass or more, 0.01% by mass or more, 0.05% by mass or more, or 0.1% by mass or more, and may be 47% by mass or less, 42% by mass or less, 37% by mass or less, 32% by mass or less, or 27% by mass or less, relative to the entire oil-in-water composition.

[0092] In the oil-in-water composition of the present disclosure, the content of the fourth compound is not particularly limited, and may be, for example, 0.001% by mass or more, 0.005% by mass or more, 0.01% by mass or more, 0.05% by mass or more, or 0.1% by mass or more, and may be 55% by mass or less, 50% by mass or less, 45% by mass or less, 40% by mass or less, or 35% by mass or less, relative to the entire oil-in-water composition.

[0093] When the oil-in-water composition of the present disclosure contains the fifth compound, the content thereof is not particularly limited and may be, for example, 0.001% by mass or more, 0.005% by mass or more, 0.01% by mass or more, 0.05% by mass or more, or 0.1% by mass or more, and may be 55% by mass or less, 50% by mass or less, 45% by mass or less, 40% by mass or less, or 35% by mass or less, relative to the entire oil-in-water composition.

[0094] The oil component is not particularly limited, and examples thereof include liquid oils and fats, solid oils and fats, waxes, hydrocarbon oils, higher fatty acids, higher alcohols, synthetic ester oils, silicone oils, etc. The oil component is preferably liquid at atmospheric pressure and 25°C.

[0095] The oily component preferably contains a component that softens the stratum corneum (stratum corneum softening component), such as at least one selected from the group consisting of di(phytosteryl / octyldodecyl) lauroyl glutamate, polybutylene glycol, castor oil, and phytosteryl macadamia nut fatty acid.

[0096] Examples of liquid oils and fats include avocado oil, camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, camellia oil, castor oil, linseed oil, safflower oil, cottonseed oil, perilla oil, soybean oil, peanut oil, tea seed oil, kaya oil, rice bran oil, Chinese tung oil, Japanese tung oil, jojoba oil, germ oil, and triglycerin.

[0097] Examples of solid fats and oils include cacao butter, coconut oil, horse fat, hardened coconut oil, palm oil, beef tallow, mutton tallow, hardened beef tallow, palm kernel oil, lard, beef bone fat, Japan wax kernel oil, hardened oil, beef trotter fat, Japan wax, and hardened castor oil.

[0098] Examples of waxes include beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, ivory wax, whale wax, montan wax, rice bran wax, lanolin, kapok wax, lanolin acetate, liquid lanolin, sugarcane wax, lanolin fatty acid isopropyl, hexyl laurate, reduced lanolin, jojoba wax, hard lanolin, shellac wax, POE lanolin alcohol ether, POE lanolin alcohol acetate, POE cholesterol ether, lanolin fatty acid polyethylene glycol, and POE hydrogenated lanolin alcohol ether.

[0099] Examples of hydrocarbon oils include liquid paraffin, ozokerite, squalane, pristane, paraffin, ceresin, squalene, petrolatum, and microcrystalline wax.

[0100] Examples of higher fatty acids include lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, undecylenic acid, tall acid, isostearic acid, linoleic acid, linolenic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

[0101] Examples of higher alcohols that can be used include straight-chain alcohols (e.g., lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, cetostearyl alcohol, etc.); and branched-chain alcohols (e.g., monostearyl glycerin ether (batyl alcohol), 2-decyltetradecinol, lanolin alcohol, cholesterol, phytosterol, hexyldodecanol, isostearyl alcohol, octyldodecanol, etc.).

[0102] Examples of synthetic ester oils include isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate, lanolin acetate, isocetyl stearate, isocetyl isostearate, cholesteryl 12-hydroxystearate, ethylene glycol di-2-ethylhexanoate, dipentaerythritol fatty acid esters, N-alkyl glycol monoisostearate, neopentyl glycol dicaprate, diisostearyl malate, glycerin di-2-heptylundecanoate, trimethylolpropane tri-2-ethylhexanoate, trimethylolpropane triisostearate, pentaerythritol tetra-2-ethylhexanoate, Glyceryl tri-2-ethylhexanoate, glyceryl trioctanoate, glyceryl triisopalmitate, trimethylolpropane triisostearate, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, glyceryl trimyristate, tri-2-heptylundecanoic acid glyceride, castor oil fatty acid methyl ester, oleyl oleate, acetoglyceride, 2-heptyl palmitate lauroyl-L-glutamic acid 2-octyldodecyl ester, di-2-heptylundecyl adipate, ethyl laurate, di-2-ethylhexyl sebacate, 2-hexyldecyl myristate, 2-hexyldecyl palmitate, 2-hexyldecyl adipate, diisopropyl sebacate, 2-ethylhexyl succinate, and triethyl citrate.

[0103] Examples of silicone oils include silicone compounds such as dimethylpolysiloxane, methylhydrogenpolysiloxane, methylphenylpolysiloxane, stearoxymethylpolysiloxane, polyether-modified organopolysiloxane, fluoroalkyl-polyoxyalkylene-co-modified organopolysiloxane, alkyl-modified organopolysiloxane, terminal-modified organopolysiloxane, fluorine-modified organopolysiloxane, amino-modified organopolysiloxane, silicone gel, acrylic silicone, trimethylsiloxysilicate, silicone RTV rubber, and cyclopentasiloxane.

[0104] The stratum corneum softening component is preferably contained in an amount of 0.5% by mass or more relative to the mass of the oil-in-water composition. The stratum corneum softening component can be, for example, 1% by mass or more, 2% by mass or more, or 3% by mass or more relative to the mass of the oil-in-water composition. The stratum corneum softening component can be, for example, 15% by mass or less, 12% by mass or less, 10% by mass or less, 8% by mass or less, or 5% by mass or less relative to the mass of the oil-in-water composition.

[0105] The oily component can contain an oily component having a molecular weight of 400 or less. By including an oily component having a molecular weight of 400 or less, it is possible to improve the cleansing ability of oily items to be cleaned, such as makeup. Examples of oily components having a molecular weight of 400 or less include at least one selected from the group consisting of tripropylene glycol dipivalate, isodecane, isononyl isononanoate, cetyl ethylhexanoate, ethyl isostearate, isobutyl isostearate, isodecyl neopentanoate, octyldodecyl neopentanoate, myristyl neopentanoate, and isostearyl neopentanoate.

[0106] The oil component having a molecular weight of 400 or less can be, for example, 50% by mass or more, 60% by mass or more, 70% by mass or more, 80% by mass or more, 90% by mass or more, or 100% by mass relative to the mass of the oil component.

[0107] The oily component is preferably 1 part by mass or more relative to 1 part by mass of the total mass of the first compound, the second compound, the third compound, the fourth compound, and the fifth compound (if the fifth compound is contained) (i.e., the mass of the gel composition excluding water), and more specifically, it can be 5 parts by mass or more, 10 parts by mass or more, 15 parts by mass or more, 20 parts by mass or more, 25 parts by mass or more, 30 parts by mass or more, 35 parts by mass or more, or 40 parts by mass or more. When the oily component is 1 part by mass or more, the efficacy of the oily component can be fully exerted. Furthermore, the oily component is preferably 50 parts by mass or less per part by mass of the total mass of the first compound, the second compound, the third compound, the fourth compound, and the fifth compound (if the fifth compound is contained), and more specifically, can be 45 parts by mass or less, 40 parts by mass or less, 35 parts by mass or less, 30 parts by mass or less, 25 parts by mass or less, 20 parts by mass or less, 15 parts by mass or less, or 10 parts by mass or less. When the oily component is 50 parts by mass or less, coating with the gel composition can be easily performed.

[0108] The content of the oily component can be, for example, 1% by mass or more, or 5% by mass or more, relative to the mass of the oil-in-water composition, and can be, for example, 50% by mass or less, or 25% by mass or less, relative to the mass of the oil-in-water composition.

[0109] The oil-in-water composition of the present disclosure may further contain water other than the water contained in the gel composition. The water content may be 10% by mass or more, 15% by mass or more, 20% by mass or more, 25% by mass or more, 30% by mass or more, 35% by mass or more, or 40% by mass or more, relative to the mass of the composition. The water content may be 90% by mass or less, 80% by mass or less, 70% by mass or less, 60% by mass or less, 50% by mass or less, 40% by mass or less, 30% by mass or less, 25% by mass or less, or 20% by mass or less, relative to the mass of the composition. The water content here includes not only the water in the aqueous phase but also the water contained in the gel composition.

[0110] The oil-in-water composition of the present disclosure may further comprise a powder. The powder may be a powder whose particle surface is hydrophobic. The hydrophobic powder may also include powder whose particle surface has been hydrophobized. It is believed that at least a portion of the hydrophobic powder is encapsulated in the oil droplet particles (oil phase) in the oil-in-water composition.

[0111] A portion of the hydrophobic powder may be present in the aqueous phase. It is believed that the gel composition of the present disclosure adheres to at least a portion of the surface of the hydrophobic powder in the aqueous phase. This improves the dispersibility of the hydrophobic powder even in the aqueous phase.

[0112] Examples of methods for hydrophobizing powder include hydrophobizing powders using silicone resins such as methylhydrogenpolysiloxane and dimethylpolysiloxane, dextrin fatty acid esters, higher fatty acids, higher alcohols, fatty acid esters, metal soaps, alkyl phosphate ethers, fluorine compounds, or hydrocarbons such as squalane and paraffin by a wet method using a solvent, a gas-phase method, a mechanochemical method, or the like. The hydrophobic powder can be, for example, a hydrophobized metal oxide powder. The metal oxide can be, for example, a powder that acts as an ultraviolet scattering agent. Examples of metal oxides include zinc oxide, titanium oxide, iron oxide, and cerium oxide.

[0113] The hydrophobic powder may have a primary particle size of 10 nm or more. The hydrophobic powder may have a primary particle size of, for example, 500 nm or less, 200 nm or less, 100 nm or less, 50 nm or less, or 40 nm or less. The average particle size of the primary particles of the hydrophobic powder can be measured using a dynamic light scattering method.

[0114] When multiple types of hydrophobic powders are present, the average particle size of the primary particles of the hydrophobic powders can be calculated by taking into account the abundance ratio of each powder, i.e., the sum of the values ​​obtained by multiplying the particle size (catalog value) of each powder by the mass ratio of each powder to the total amount of hydrophobic powder.

[0115] The powder is not particularly limited as long as it can be generally used for cosmetics and the like. Examples of the powder include inorganic powders (for example, talc, kaolin, mica, sericite, muscovite, phlogopite, synthetic mica, lepidolite, biotite, lepidolite, calcined mica, calcined talc, vermiculite, magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, silica, zeolite, glass, barium sulfate, calcined calcium sulfate (calcined gypsum), calcium phosphate, fluorapatite, hydroxyapatite, ceramic powder, metal soap (for example, zinc myristate, calcium palmitate, aluminum stearate), boron nitride, etc.); organic powders (for example, polyamide resin powder (nylon powder), polyethylene powder, polymethyl methacrylate powder, polystyrene powder, styrene-acrylic acid copolymer resin powder, benzoguanamine resin powder, polytetrafluoroethylene powder, cellulose powder, silicone resin powder, silk powder, wool powder, urethane powder, etc.); inorganic white pigments (for example, titanium dioxide, zinc oxide, etc.); inorganic red pigments (for example, iron oxide (red iron oxide), iron titanate, etc.); inorganic brown pigments (for example, γ-iron oxide, etc.), inorganic yellow pigments (yellow iron oxide, ochre, etc.), inorganic black pigments (black iron oxide, carbon black, low-order titanium oxide, etc.), inorganic purple pigments (for example, manganese violet, cobalt violet, etc.); inorganic green pigments (for example, chromium oxide, chromium hydroxide, cobalt titanate, etc.); inorganic blue pigments (for example, ultramarine, Prussian blue, etc.); pearl pigments (for example, titanium oxide-coated mica, titanium oxide-coated bismuth oxychloride, titanium oxide-coated talc, colored titanium oxide-coated mica, bismuth oxychloride, fish scale foil, etc.); metal powder pigments (for example, aluminum powder, copper powder, etc.);Organic pigments such as zirconium, barium or aluminum lakes (e.g., organic pigments such as Red No. 201, Red No. 202, Red No. 204, Red No. 205, Red No. 220, Red No. 226, Red No. 228, Red No. 405, Orange No. 203, Orange No. 204, Yellow No. 205, Yellow No. 401, and Blue No. 404, Red No. 3, Red No. 104, Red No. 106, Red No. 227, Red No. 230, Red No. 401, Red No. 505, Orange No. 205, Yellow No. 4, Yellow No. 5, Yellow No. 202, Yellow No. 203, Green No. 3, and Blue No. 1, etc.); natural pigments (e.g., chlorophyll, β-carotene, etc.); wax powders (e.g., carnauba wax powder, etc.); starch powders (e.g., corn starch powder, rice starch powder, etc.);

[0116] The hydrophobic powder is preferably present in an amount of 0.5% by mass or more relative to the mass of the oil-in-water composition. For example, the hydrophobic powder can be present in an amount of 1% by mass or more, 3% by mass or more, 5% by mass or more, 8% by mass or more, 10% by mass or more, 15% by mass or more, or 20% by mass or more relative to the mass of the oil-in-water composition. If the hydrophobic powder is present in an amount of less than 0.5% by mass, the effect of the hydrophobic powder cannot be obtained. The hydrophobic powder is preferably present in an amount of 30% by mass or less relative to the mass of the oil-in-water composition. For example, the hydrophobic powder can be present in an amount of 25% by mass or less, 20% by mass or less, 15% by mass or less, 10% by mass or less, 8% by mass or less, 5% by mass or less, or 3% by mass or less relative to the mass of the oil-in-water composition. If the hydrophobic powder exceeds 30% by mass, the hydrophobic powder cannot be fully encapsulated in the oil phase.

[0117] The oil-in-water composition of the present disclosure allows for stable dispersion of an oily component, and when applied to the skin, the oil-in-water composition of the present disclosure can exhibit a high barrier function based on the gel composition of the present disclosure.

[0118] In the gel compositions and oil-in-water compositions of the present disclosure, there are cases where it is impossible or almost impractical to directly identify the phase structure etc. by the composition, In such cases, the gel compositions and oil-in-water compositions of the present disclosure should be allowed to be identified by their manufacturing methods.

[0119] The oil-in-water composition of the present disclosure may be an emulsified composition, i.e., an oil-in-water emulsion composition.

[0120] [Manufacturing Method] A method for manufacturing a gel composition according to the first to third embodiments of the present disclosure will now be described. The method for manufacturing a gel composition can include, for example, the steps of heating and melting the first to fourth compounds (or the first to fifth compounds, if a fifth compound is included) and mixing and stirring the melted mixture with water. The first to fifth compounds can be melted at, for example, 70°C to 110°C. It is preferable to heat the water to the same temperature as the mixture (for example, 70°C to 80°C; for example, ±15°C). A lamellar gel phase can be obtained by mixing with water and then cooling.

[0121] A method for producing an oil-in-water composition according to a third embodiment of the present disclosure will now be described. In a first aspect, the method for producing an oil-in-water composition can include, for example, a step of emulsifying an oily component in a gel composition (lamellar gel phase) and a step of adding an aqueous component after emulsification. The step of emulsifying the oily component can include, for example, a step of preparing a solution by dissolving the first to fourth compounds (or the first to fifth compounds, if a fifth compound is included) in a polyhydric alcohol (e.g., dipropylene glycol or 1,3-butylene glycol), and a step of adding and emulsifying the oily component to the solution. For example, the oil-in-water composition of the present disclosure can be produced using a non-aqueous emulsification method (D-phase emulsification method). Using a non-aqueous emulsification method can produce finer emulsion particles. Furthermore, the lamellar gel phase can be adsorbed to the oil-water interface.

[0122] The oil-in-water composition of the present disclosure may contain other ingredients, such as amphoteric surfactants, hydrophilic nonionic surfactants, lipophilic nonionic surfactants, water-soluble polymers, thickeners, moisturizers, film-forming agents, oil-soluble UV absorbers, water-soluble UV absorbers, sequestering agents, amino acids, organic amines, polymer emulsions, pH adjusters, skin nutrients, vitamins, antioxidants, antioxidant aids, fragrances, and the like, as needed, within the scope that does not impair the effects of the present disclosure.

[0123] Examples of amphoteric surfactants include imidazoline-based amphoteric surfactants (e.g., 2-undecyl-N,N,N-(hydroxyethylcarboxymethyl)-2-imidazoline sodium, 2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyloxy disodium salt, etc.); betaine-based surfactants (e.g., 2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryldimethylaminoacetic acid betaine, alkyl betaine, amido betaine, sulfobetaine, etc.).

[0124] Examples of hydrophilic nonionic surfactants include POE-sorbitan fatty acid esters (e.g., POE-sorbitan monooleate, POE-sorbitan monostearate, POE-sorbitan monooleate, POE-sorbitan tetraoleate, etc.); POE-sorbitol fatty acid esters (e.g., POE-sorbitol monolaurate, POE-sorbitol monooleate, POE-sorbitol pentaoleate, POE-sorbitol monostearate, etc.); POE-glycerin fatty acid esters (e.g., POE-glycerin monostearate, POE-monooleates such as POE-glycerol monoisostearate, POE-glycerol triisostearate, etc.); POE-fatty acid esters (for example, POE-distearate, POE-monodioleate, ethylene glycol distearate, etc.); POE-alkyl ethers (for example, POE-lauryl ether, POE-oleyl ether, POE-stearyl ether, POE-behenyl ether, POE-2-octyldodecyl ether, POE-cholestanol ether, etc.); Pluronic types (for example, Pluronic (registered trademark) trademarks), etc.); POE·POP-alkyl ethers (for example, POE·POP-cetyl ether, POE·POP-2-decyltetradecyl ether, POE·POP-monobutyl ether, POE·POP-hydrogenated lanolin, POE·POP-glycerin ether, etc.); tetraPOE·tetraPOP-ethylenediamine condensates (for example, Tetronic, etc.); POE-castor oil hydrogenated castor oil derivatives (for example, POE-castor oil, POE-hydrogenated castor oil, POE-hydrogenated castor oil monoisostearate, POE-hydrogenated castor oil triisostearate, PO Examples of the POE-hydrogenated castor oil include POE-hydrogenated castor oil monopyroglutamic acid monoisostearate diester, POE-hydrogenated castor oil maleic acid, etc.; POE-beeswax / lanolin derivatives (for example, POE-sorbitol beeswax, etc.); alkanolamides (for example, coconut oil fatty acid diethanolamide, lauric acid monoethanolamide, fatty acid isopropanolamide, etc.); POE-propylene glycol fatty acid esters; POE-alkylamines; POE-fatty acid amides; sucrose fatty acid esters; alkylethoxydimethylamine oxide; and trioleyl phosphate.

[0125] Examples of lipophilic nonionic surfactants include sorbitan fatty acid esters (e.g., sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexylate, diglycerol sorbitan tetra-2-ethylhexylate, etc.); glycerin polyglycerin fatty acids (e.g., glycerin monocottonseed oil fatty acid, glycerin monoerucate, glycerin sesquioleate, glycerin monostearate, glycerin α,α'-oleic acid pyroglutamate, glycerin monostearate malate, etc.); propylene glycol fatty acid esters (e.g., propylene glycol monostearate, etc.); hydrogenated castor oil derivatives; and glycerin alkyl ethers.

[0126] Examples of natural water-soluble polymers include plant-derived polymers (e.g., gum arabic, tragacanth gum, galactan, guar gum, carob gum, karaya gum, carrageenan, pectin, agar, quince seed (marmella), algae colloid (cassowia extract), starch (rice, corn, potato, wheat), glycyrrhizic acid); microbial-derived polymers (e.g., xanthan gum, dextran, succinoglucan, pullulan, etc.); and animal-derived polymers (e.g., collagen, casein, albumin, gelatin, etc.).

[0127] Examples of semi-synthetic water-soluble polymers include starch-based polymers (e.g., carboxymethyl starch, methylhydroxypropyl starch, etc.); cellulose-based polymers (methyl cellulose, ethyl cellulose, methylhydroxypropyl cellulose, hydroxyethyl cellulose, sodium cellulose sulfate, hydroxypropyl cellulose, carboxymethyl cellulose, sodium carboxymethyl cellulose, crystalline cellulose, cellulose powder, etc.); and alginic acid-based polymers (e.g., sodium alginate, propylene glycol alginate, etc.).

[0128] Examples of synthetic water-soluble polymers include vinyl polymers (e.g., polyvinyl alcohol, polyvinyl methyl ether, polyvinylpyrrolidone, carboxyvinyl polymer, etc.); polyoxyethylene polymers (e.g., polyoxyethylene polypropylene copolymers of polyethylene glycol 20,000, 40,000, 60,000, etc.); acrylic polymers (e.g., sodium polyacrylate, polyethyl acrylate, polyacrylamide, etc.); polyethyleneimine; cationic polymers, etc.

[0129] Examples of thickeners include gum arabic, carrageenan, karaya gum, tragacanth gum, carob gum, quince seed (marmelo), casein, dextrin, gelatin, sodium pectinate, sodium alginate, methylcellulose, ethylcellulose, carboxymethylcellulose (CMC), hydroxyethylcellulose, hydroxypropylcellulose, polyvinyl alcohol (PVA), polyvinyl methyl ether (PVM), PVP (polyvinylpyrrolidone), sodium polyacrylate, carboxyvinyl polymer, locust bean gum, guar gum, tamarind gum, dialkyldimethylammonium cellulose sulfate, xanthan gum, aluminum magnesium silicate, bentonite, hectorite, aluminum magnesium silicate (veegum), laponite, silicic anhydride, taurate-based synthetic polymers, and acrylate-based synthetic polymers.

[0130] Examples of moisturizing agents include polyethylene glycol, propylene glycol, glycerin, 1,3-butylene glycol, xylitol, sorbitol, maltitol, chondroitin sulfate, hyaluronic acid, mucoitin sulfate, caronic acid, atelocollagen, cholesteryl-12-hydroxystearate, sodium lactate, bile salts, dl-pyrrolidone carboxylate, alkylene oxide derivatives, short-chain soluble collagen, diglycerin (EO)PO adduct, Rosa illustrator extract, yarrow extract, melilot extract, and the like.

[0131] Examples of coating agents include anionic coating agents (e.g., (meth)acrylic acid / (meth)acrylic acid ester copolymers, methyl vinyl ether / maleic anhydride polymers, etc.), cationic coating agents (e.g., cationized cellulose, dimethyldiallylammonium chloride polymers, dimethyldiallylammonium chloride / acrylamide copolymers, etc.), and nonionic coating agents (e.g., polyvinyl alcohol, polyvinylpyrrolidone, polyvinyl acetate, polyacrylic acid ester copolymers, (meth)acrylamide, polymeric silicone, silicone resins, trimethylsiloxysilicate, etc.).

[0132] Examples of oil-soluble ultraviolet absorbers include benzoic acid-based ultraviolet absorbers (e.g., para-aminobenzoic acid (hereinafter abbreviated as PABA), PABA monoglycerin ester, N,N-dipropoxy PABA ethyl ester, N,N-diethoxy PABA ethyl ester, N,N-dimethyl PABA ethyl ester, N,N-dimethyl PABA butyl ester, N,N-dimethyl PABA ethyl ester, diethylaminohydroxybenzoylhexyl benzoate, etc.); anthranilic acid-based ultraviolet absorbers (e.g., homomenthyl-N-acetylanthranilate, etc.); salicylic acid-based ultraviolet absorbers (e.g., benzoic acid monoglyceride, benzoic acid di ... cinnamic acid-based ultraviolet absorbers (e.g., ethylhexyl salicylate, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate, homosalate, etc.); cinnamic acid-based ultraviolet absorbers (e.g., octyl methoxycinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate, propyl-p-methyl 2-ethylhexyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, octyl-p-methoxycinnamate (2-ethylhexyl-p-methoxycinnamate, ethylhexyl methoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate, cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl-α-cyano-β-phenylcinnamate, glyceryl mono-2-ethylhexanoyl-di-para-methoxycinnamate, etc.); 3-(4'-methyl 2-(2'-hydroxy-5'-t-octylphenyl)benzotriazole; 2-(2'-hydroxy-5'-methylphenyl)benzotriazole; dibenzalazine; dianisoylmethane; 4-methoxy-4'-t-butyldibenzoylmethane; 5-(3,3-dimethyl-2-norbornylidene)-3-pentan-2-one, dimorpholinopyridazinone;2-ethylhexyl-2-cyano-3,3-diphenylacrylate (octocrellin); 2,4-bis-{[4-(2-ethylhexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-(1,3,5)-triazine, benzophenone-based ultraviolet absorbers (e.g., 2,4-dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2,2',4 , 4'-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone, etc.);

[0133] Examples of the water-soluble ultraviolet absorber include benzophenone-based ultraviolet absorbers (e.g., 2-hydroxy-4-methoxybenzophenone-5-sulfonate, etc.), benzylidene camphor-based ultraviolet absorbers (benzylidene camphorsulfonic acid, terephthalidenedicamphorsulfonic acid, etc.), and phenylbenzimidazole-based ultraviolet absorbers (phenylbenzimidazolesulfonic acid, etc.).

[0134] Examples of sequestering agents include 1-hydroxyethane-1,1-diphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid tetrasodium salt, disodium edetate, trisodium edetate, tetrasodium edetate, sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid, phosphoric acid, citric acid, ascorbic acid, succinic acid, edetic acid, and trisodium ethylenediaminehydroxyethyltriacetate.

[0135] Examples of amino acids include neutral amino acids (e.g., threonine, cysteine, etc.) and basic amino acids (e.g., hydroxylysine, etc.). Examples of amino acid derivatives include sodium acyl sarcosine (sodium lauroyl sarcosine), acyl glutamate, sodium acyl β-alanine, glutathione, pyrrolidone carboxylic acid, etc.

[0136] Examples of organic amines include monoethanolamine, diethanolamine, triethanolamine, morpholine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, and 2-amino-2-methyl-1-propanol.

[0137] Examples of polymer emulsions include acrylic resin emulsion, polyethyl acrylate emulsion, acrylic resin liquid, polyacrylic alkyl ester emulsion, polyvinyl acetate resin emulsion, and natural rubber latex.

[0138] Examples of pH adjusters include buffers such as lactic acid-sodium lactate, citric acid-sodium citrate, and succinic acid-sodium succinate.

[0139] Examples of vitamins include vitamins A, B1, B2, B6, C, E and their derivatives, pantothenic acid and its derivatives, biotin, etc.

[0140] Examples of antioxidants include tocopherols, dibutylhydroxytoluene, butylhydroxyanisole, and gallic acid esters.

[0141] Examples of antioxidant aids include phosphoric acid, citric acid, ascorbic acid, maleic acid, malonic acid, succinic acid, fumaric acid, cephalin, hexametaphosphate, phytic acid, and ethylenediaminetetraacetic acid.

[0142] Other ingredients that can be added include, for example, preservatives (ethylparaben, butylparaben, chlorphenesin, phenoxyethanol, etc.); anti-inflammatory agents (for example, glycyrrhizinic acid derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, zinc oxide, allantoin, etc.); whitening agents (for example, placenta extract, saxifrage extract, arbutin, etc.); various extracts (for example, Phellodendron bark, Coptis chinensis, Lithospermum root, Peony, Swertia japonica, Birch, Sage, Loquat, Carrot, Aloe, Mallow, Iris, Grape, Job's tears, Loofah, Lily, Saffron, Cnidium rhizome, Ginger, Hypericum perforatum, Ononis, Garlic, Capsicum, Citrus fruit, Tomato, float, seaweed, etc.), activators (for example, royal jelly, photosensitizers, cholesterol derivatives, etc.); blood circulation promoters (for example, nonylic acid vanillylamide, nicotinic acid benzyl ester, nicotinic acid β-butoxyethyl ester, capsaicin, zingerone, cantharides tincture, ichthammol, tannic acid, α-borneol, tocopherol nicotinate, inositol hexanicotinate, cyclandelate, cinnarizine, tolazoline, acetylcholine, verapamil, cepharanthine, γ-oryzanol, etc.); antiseborrheic agents (for example, sulfur, thianthol, etc.); anti-inflammatory agents (for example, tranexamic acid, thiotaurine, hypotaurine, etc.).

[0143] The gel composition and oil-in-water composition of the present disclosure will be described below with reference to examples. However, the gel composition and oil-in-water composition of the present disclosure are not limited to the following examples. Unless otherwise specified, the content of each component shown in each table is in mass%.

[0144] [Examples 1 to 4] The ingredients shown in Table 1, excluding ion-exchanged water, were melted at 100°C to prepare a homogeneous mixture. Ion-exchanged water at 70 to 80°C was added to the mixture, mixed, and then cooled. Next, the mixture was degassed by centrifugation to prepare the gel compositions of Examples 1 to 4.

[0145] Each of the prepared compositions was subjected to small-angle and wide-angle X-ray scattering measurement, differential scanning calorimetry, and polarizing microscope imaging.

[0146] [Small-Angle / Wide-Angle X-Ray Scattering Measurement] Small-angle / wide-angle X-ray scattering of the composition of each test example was measured at 20°C using a SWAXS measuring device SAXS Sees mc2 (manufactured by Anton Paar GmbH, Graz, Austria).

[0147] [Differential Scanning Calorimetry] A differential scanning calorimetry device, DSC Q2000 (Waters Corporation, TA Instruments), was used. Approximately 7 mg of the composition of each test example was placed in an aluminum pan and the temperature was raised from 25 to 115°C at a rate of 2°C per minute to measure.

[0148] [Polarizing Microscope Image Capturing] Polarizing microscope images were taken using a system polarizing microscope model BX53 manufactured by Olympus Corporation at a magnification of 400 times, with polarizing plates held in crossed Nicols.

[0149] Figure 1 shows the small-angle and wide-angle X-ray scattering chart of the gel composition of Example 3. There is a peak corresponding to the long spacing of the lamellar gel on the small-angle side, which indicates that the composition of Example 3 has a lamellar structure. In addition, the scattering vector q = 1.5 nm －１ The peaks around this point indicate the presence of a hexagonal lattice with an α-type structure, with a high degree of regularity in the sublattice planes. This confirmed that the resulting composition was α-gel. The α-gel structure inhibits the precipitation of hydrated crystals and provides a high barrier function. The vertical axis, "Int.", indicates strength (the same applies to Figures 4 and 7).

[0150] Figure 2 shows a differential scanning calorimetry chart of Example 3. From Figure 2, it can be seen that the presence of an endothermic peak indicates that at least the composition of Example 3 has a eutectic point. Having a eutectic point can suppress the precipitation of some crystals.

[0151] FIG. 3 shows a polarizing microscope image of Example 3, and the formation of a lamellar gel was confirmed.

[0152] Although measurement charts and images of other examples are not shown, the values ​​of the endothermic peaks observed by differential scanning calorimetry are shown in the "DSC" column of Table 1. The results of the small-angle and wide-angle X-ray scattering charts observed in the small-angle and wide-angle X-ray scattering charts were evaluated based on the following criteria and are shown in the "SAXS" column of Table 1. The results of the wide-angle X-ray scattering charts observed in the small-angle and wide-angle X-ray scattering charts were evaluated based on the following criteria and are shown in the "WAXS" column of Table 1. (Evaluation Criteria) "A": A single peak was observed; "B": Another peak was observed in part of the peak; "C": Many peaks were observed; "D": No peaks were observed. Here, in the case of criterion "C," many peaks were present, and although they were not as clear as in the cases of "A" and "B," it can be said that a gel had formed. In addition, in the case of criterion "D," it was determined that a gel composition had not formed.

[0153]

[0154] As is clear from the results in Table 1, it was found that all of the compositions of Examples 1 to 4 had an α-gel structure. In addition, the presence of a lamellar gel phase having a hexagonal structure was confirmed.

[0155] Examples 5 to 16 Gel compositions of Examples 5 to 16 were prepared in the same manner as in Example 1 using the components shown in Table 2.

[0156] For each of the prepared compositions, small-angle and wide-angle X-ray scattering measurements, differential scanning calorimetry, and polarized light microscope images were taken in the same manner as in Example 1. Figure 4 shows a small-angle and wide-angle X-ray scattering chart for the gel composition of Example 15. Figure 5 shows a differential scanning calorimetry chart for Example 15. Figure 6 shows a polarized light microscope image for Example 15. Measurement charts and images for other Examples are not shown, but they were evaluated in the same manner as in Example 15, and the evaluation results are shown in Table 2.

[0157]

[0158] As is clear from Table 2, all of the compositions of Examples 5 to 16 were found to have an α-gel structure. In addition, the presence of a lamellar gel phase having a hexagonal structure was confirmed.

[0159] Examples 17 to 22 Gel compositions of Examples 17 to 22 were prepared in the same manner as in Example 1 using the components shown in Table 3.

[0160] For each of the prepared compositions, small-angle and wide-angle X-ray scattering measurements, differential scanning calorimetry, and polarized light microscope images were taken in the same manner as in Example 1. Figure 7 shows a small-angle and wide-angle X-ray scattering chart for the gel composition of Example 22. Figure 8 shows a differential scanning calorimetry chart for Example 22. Figure 9 shows a polarized light microscope image for Example 22. Measurement charts and images for other Examples are not shown, but they were evaluated in the same manner as in Example 22, and the evaluation results are shown in Table 3.

[0161]

[0162] As is clear from Table 3, all of the compositions of Examples 17 to 22 were found to have an α-gel structure. In addition, the presence of a lamellar gel phase having a hexagonal structure was confirmed.

[0163] Example 23 and Comparative Examples 1 and 2 Based on the components in Table 4, oil-in-water emulsion compositions of Example 23 and Comparative Examples 1 and 2 were prepared.

[0164] More specifically, the composition of Example 23 was prepared by a non-aqueous emulsification method using a high-speed homogenizer.

[0165] The composition of Comparative Example 1 was prepared by the agent-in-water method using a low-speed homogenizer.

[0166] The composition of Comparative Example 2 was prepared by the agent-in-oil method using a high-speed homogenizer.

[0167]

[0168] <Evaluation of Antioxidant Effect> The antioxidant effect of each of the compositions of Example 23, Comparative Example 1 and Comparative Example 2 was evaluated by the following experiment.

[0169] [Evaluation of Hydroxyl Radical (·OH) Scavenging Ability] The radical scavenging activity of the test product against ·OH generated from Fe and hydrogen peroxide was measured. More specifically, the experiment was carried out as follows: (1) 20 μL of test product or control solution was placed in a 96-well plate, and 80 μL of a 50 μM methylene blue solution was added. Four wells were used per treatment group (N=4). (2) Next, 100 μL of a mixed solution of 1 mM iron(II) chloride tetrahydrate and 2.3 mM hydrogen peroxide was added to each well to initiate the reaction. (3) Immediately after the start of the reaction, the methylene blue absorbance (665 nm) of each well was measured using a plate reader under the following measurement conditions for 30 minutes. (4) The higher the absorbance at 665 nm after 30 minutes, the stronger the antioxidant activity of the test product. (Plate reader conditions) Kinetics mode Agitation before measurement: Double Orbital, 5 seconds, 282 cpm (3 mm) Scan conditions: Endpoint, Absorbance: 665 nm, Read Speed: Sweep Measurement interval: every 5 minutes, measurement up to 30 minutes.

[0170] As a control, Milli-Q (registered trademark) water was used instead of the composition of the example. For "MB only," a mixed solution of 80 μL of 50 μM methylene blue and 120 μL of water was used. The results are shown in FIG. 10.

[0171] As shown in FIG. 10, Example 23 had a higher absorbance than the control, meaning that it had a significantly higher antioxidant effect.

[0172] [Evaluation of Inhibition of Lipid Peroxide Formation] Conjugated dienes produced by oxidation of linoleic acid, an unsaturated fatty acid, were measured. More specifically, the measurement was carried out as follows: (1) 970 μL of a 10 mM sodium dodecyl sulfate (SDS) solution containing 0.26 mM linoleic acid, 20 μL of the test product, and the control were added to a 1.5 mL tube and mixed. (2) Subsequently, 10 μL of a 0.2% 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH) solution was added to the 1.5 mL tube from (1), and the solution was mixed using a vortex mixer. (3) 200 μL of the solution was dispensed into an ultraviolet-transmitting 96-well plate, and the absorbance at 233 nm (OD ２３３ ) was measured. Four wells were used for each treatment group (test N=4). (4) The UV-transparent 96-well plate was sealed with a plate seal and incubated at 50°C for 3 hours. (5) After the reaction in (4), the absorbance at 233 nm (OD) was measured using a plate reader under the following conditions: ２３３ (Plate reader conditions) Pre-measurement stirring: Double Orbital, 10 sec, 282 cpm (3 mm) Scan conditions: Endpoint, 233 nm, Read Speed ​​(Normal) (6) OD of test product and control ２３３ The lipid peroxide production rate and lipid peroxide production inhibition rate of the test product were calculated using the following formula: (Method for calculating lipid peroxide production rate) Lipid peroxide production rate (%) = (S ３ -S ０ ) / Average of(C ３ -C ０ ) x 100 S ３ : OD of test product after 3 hours of reaction ２３３ S ０ : OD of sample before reaction ２３３ C ３ : OD of control after 3 hours of reaction ２３３ C ０ : OD of control before reaction ２３３ A calculation method was adopted in which the average value of the control before and after the reaction was used as the denominator, resulting in an average value of 100 for the control.

[0173] As a control, water (Milli-Q (registered trademark) water or ion-exchanged water) was used instead of the compositions of the examples or comparative examples. The results obtained are shown in FIG.

[0174] 11, the composition of Example 23 was found to have a significantly lower rate of lipid peroxide formation than the control. Furthermore, the composition of Example 23 was found to have a significantly lower rate of lipid peroxide formation than the composition of Comparative Example 1 (Tukey-Kramer test).

[0175] [Evaluation of Inhibition of Stratum Corneum Protein Carbonylation] Inhibition of stratum corneum protein carbonylation was evaluated in Examples and Comparative Examples. More specifically, the evaluation was carried out as follows: (1) A preparation (the composition of an Example or Comparative Example) was applied to clean, washed skin. After a certain period of time, the skin was washed and the stratum corneum was tape-stripped. (2) The collected stratum corneum from the tape strip was immersed in a 100 μmol / L aqueous solution of sodium hypochlorite (Wako Pharmaceutical Co., Ltd.) at 37°C for 16 hours. (3) The immersed stratum corneum from the tape strip was removed, washed with Milli-q (registered trademark) water, and dried. After drying, the sample was immersed in a pre-adjusted MES-NaOH buffer solution (pH 5.5). 0.3 mg of fluorescein-5-thiosemicarbazide was dissolved in 170 μM DMSO and added to the buffer solution, followed by standing in a light-shielding container for 1 hour. (4) The specimen was removed from the light-shielding container, gently washed with PBS buffer, and then dried in a light-shielding state. (5) The specimen was reattached to the slide glass, and then observed under a fluorescence microscope and images were captured. (6) The images were binarized, and the degree of carbonylation was compared and evaluated between specimens uncoated with the formulation and specimens coated with the formulation.

[0176] The evaluation results are shown in FIG.

[0177] As shown in FIG. 12, Example 23 had the fewest number of white areas (i.e., areas of carbonylated stratum corneum protein) compared to Comparative Examples 1 and 2, indicating that it had the highest antioxidant effect.

[0178] The gel composition and oil-in-water composition of the present disclosure have been described based on the above embodiments and examples, but are not limited to the above embodiments and examples, and may include various modifications, changes, and improvements to each disclosed element (including elements described in the claims, specification, and drawings) within the scope of the present invention and based on the basic technical concept of the present invention. Furthermore, various combinations, substitutions, and selections of each disclosed element are possible within the scope of the claims of the present invention.

[0179] Further objects, purposes and modes (including modifications) of the present invention will become apparent from the entire disclosure of the present invention including the claims.

[0180] With respect to numerical ranges set forth herein, unless otherwise specified, any numerical value or range falling within that range should be construed as being specifically set forth herein.

[0181] The claims and the following appended notes in the claims are intended to be in any combination and interrelationship.

[0182] Some or all of the above embodiments can be described as in the following supplementary notes, but are not limited to the following descriptions. Each supplementary note can also be combined with each claim described in the claims. [Supplementary Note 1] A method for producing an oil-in-water composition, comprising: a mixing step of melting the first compound, the second compound, the third compound, and the fourth compound to prepare a mixture; a water addition step of adding water to the mixture to prepare a lamellar gel phase; and a coating step of coating an oily component with the lamellar gel phase. [Supplementary Note 2] The manufacturing method described in the above supplementary note, wherein the fifth compound is further added in the mixing step. [Supplementary Note 3] The manufacturing method described in the above supplementary note, wherein the mixture is heated to a temperature within ±15°C of the heating temperature before the water addition. [Supplementary Note 4] A method of use, comprising applying a gel composition and / or an oil-in-water composition of the present disclosure to an external skin preparation.

[0183] The gel composition and oil-in-water composition of the present disclosure can be applied to the body, for example, skin, hair, etc. For example, the oil-in-water composition of the present disclosure can be applied to cosmetics (e.g., foundation, sunscreen cosmetics, makeup base, BB cream, etc.), hair styling products, cleansers (e.g., cleansers, shampoos, etc.), etc.

Claims

1. A gel composition comprising the following compounds: one or more first compounds represented by Formula I below; one or more second compounds represented by Formula II below; one or more third compounds represented by Formula III below; and one or more fourth compounds selected from the group consisting of ascorbic acid and salts thereof, ascorbic acid monoesters, ascorbic acid diesters, tocopherol and esters thereof, glycyrrhetinic acid and esters and salts thereof, and betamethasone and esters thereof: (In Formula I, R １ is at least one selected from the group consisting of a steroid skeleton and a cholesterol skeleton, and R ２ is an alkylene group having 2 to 4 carbon atoms, and m is an integer of 5 to 30. (In Formula II, R ３ is a linear acyl group or a linear alkyl group having 16 to 24 carbon atoms, and R ４ is an alkylene group having 2 to 4 carbon atoms, and R ５ is a linear acyl group or a linear alkyl group having 16 to 24 carbon atoms, and n is an integer of 4 to 8. (In Formula III, R ６ is a linear acyl group or a linear alkyl group having 16 to 24 carbon atoms, and R ７ is an alkylene group having 2 to 4 carbon atoms, and p is an integer of 5 to 30.

2. The gel composition of claim 1, wherein the first compound, the second compound, the third compound, and the fourth compound form a lamellar gel phase.

3. The gel composition of claim 1, which has peaks in its X-ray scattering pattern that indicate a hexagonal crystal structure.

4. The gel composition according to claim 1, wherein the first compound is 49 to 88 parts by mass, the second compound is 6 to 23 parts by mass, the third compound is 6 to 28 parts by mass, and the fourth compound is 3 to 35 parts by mass, relative to a total of 100 parts by mass of the first compound, the second compound, and the third compound.

5. The gel composition of claim 1, further comprising water.

6. The gel composition of claim 1, further comprising one or more fifth compounds selected from the group consisting of gamma-oryzanol, phytosterol, cholesterol, ceramide, lecithin, and stearic acid.

7. The gel composition according to any one of claims 1 to 6, which is a cosmetic product.

8. An oil-in-water composition comprising: the gel composition according to any one of claims 1 to 6; and an oily component, wherein at least a portion of the oily component is coated on the gel composition as oil droplets.

9. The oil-in-water composition according to claim 8, which is a cosmetic.

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