Oral composition

Abstract

An oral composition comprising an abrasive and a binder, the composition having a water-containing residual rate of 60% to 180%.

Description

Oral composition

[0001] The present invention relates to an oral composition.

[0002] Techniques for improving the solubility and residual properties of oral compositions are described in Patent Documents 1 and 2. Patent Document 1 (JP 2021-523142 A) relates to an oral care composition, such as an oral care composition and / or a dentifrice composition, that may be residue-free without sacrificing the oral health benefits typically provided by a user's brushing (paragraph 0004), and describes a unit-dose oral care composition that has a total dissolution time per dose of less than about 1,000 seconds when measured by a specific method (claim 1, paragraph 0005).

[0003] Patent Document 2 (JP 2014-129305 A) describes a toothpaste composition packaged in a tube, which contains specific amounts of cetylpyridinium chloride, specific amounts of calcium carbonate, abrasive silica, and water, and in which the total content of calcium carbonate and abrasive silica and the pH are each within specific ranges (Claim 1). The document states that this composition leaves teeth feeling smooth after brushing with a toothbrush or the like, while providing a refreshing feeling with little powder remaining in the mouth, and that it can effectively prevent the amount of cetylpyridinium chloride from decreasing, thereby enabling the composition to fully exert excellent antibacterial activity (paragraph 0009).

[0004] JP 2021-523142 A JP 2014-129305 A

[0005] Through the research of the present inventors, it became clear that there is room for improvement in the products described in the above patent documents in terms of improving cushioning properties when brushing teeth while also making it easier to spread to the teeth and gums.

[0006] The present invention provides an oral composition that has an excellent balance between cushioning properties during tooth brushing and ease of spreading over teeth and gums.

[0007] According to the present invention, the following oral composition is provided. [1] An oral composition comprising an abrasive and a binder, wherein the residual rate when wet is 60% or more and 180% or less, as measured by the following method 1. (Method 1) 1. Weigh out 2.0 g of the oral composition and 10 g of water into a 30 mL beaker. Record the weighed amount [g] of the oral composition. 2. Place a stirrer in the beaker and stir on a magnetic stirrer at 120 rpm for 20 seconds. 3. After stirring, transfer the contents of the beaker onto a nylon mesh with a pore size of 100 μm and allow to stand for 30 seconds. 4. Weigh the amount [g] of residue on the nylon mesh, and calculate the residual rate when wet based on the following formula (1): Residual rate when wet (%) = 100 * residue amount / weighed amount (1) [2] The oral composition according to [1], wherein the binder contains thickening silica. [3] The oral composition according to [1] or [2], wherein the binder comprises an organic binder. [4] The oral composition according to [3], wherein the organic binder is one or more selected from the group consisting of carboxymethylcellulose and its salts, xanthan gum, alginic acid and its salts, polyacrylic acid and its salts, carboxyvinyl polymer, hydroxyethylcellulose, hydroxypropylcellulose, pectin, tragacanth gum, gum arabic, guar gum, karaya gum, locust bean gum, gellan gum, tamarind gum, psyllium seed gum, polyvinyl alcohol, and carrageenan (excluding κ-carrageenan). [5] The oral composition according to any one of [1] to [4], further comprising a humectant. [6] The oral composition according to any one of [1] to [5], wherein the abrasive comprises abrasive silica. [7] The oral composition according to any one of [1] to [6], wherein the oral composition is a dentifrice composition. [8] The oral composition according to any one of [1] to [7], wherein the oral composition is a toothpaste composition. [9] A dentifrice in which the oral composition according to any one of [1] to [8] is filled in a tube container.

[0008] Any combination of these configurations and conversion of the present invention between methods, devices, etc. are also valid aspects of the present invention.

[0009] According to the present invention, an oral composition can be obtained that has an excellent balance between cushioning properties during tooth brushing and ease of spreading over teeth and gums.

[0010] Hereinafter, an embodiment of the present invention will be described. In this embodiment, the composition may contain each component alone or in combination of two or more. In this specification, the term "to" indicating a numerical range means "at least" or "at most," and both end values ​​are included.

[0011] (Oral Composition) In this embodiment, the oral composition contains an abrasive and a binder. The residual rate when wet, measured by the following method 1, is 60% or more and 180% or less. (Method 1) 1. Weigh out 2.0 g of oral composition and 10 g of water into a 30 mL beaker. Record the weighed amount [g] of oral composition. 2. Place a stir bar in the beaker and stir on a magnetic stirrer at 120 rpm for 20 seconds. 3. Transfer the stirred content of the beaker onto a nylon mesh with a pore size of 100 μm and leave to stand for 30 seconds. 4. Weigh the amount [g] of residue on the nylon mesh, and calculate the residual rate when wet based on the following formula (1). Residual rate when wet (%) = 100 * residue amount / weighed amount (1)

[0012] In Method 1, the measurement temperature for the residual rate when wet is specifically 25°C. In Step 1 of Method 1, the weighed amount is specifically in the range of 1.95 g to 2.04 g, preferably in the range of 1.98 g to 2.02 g. In Step 3 of Method 1, the filtrate is left to stand for 30 seconds from the point at which it is left to stand until the filtrate no longer drips from the nylon mesh.

[0013] The present inventors have focused on the ingredients and properties of oral compositions as design guidelines for improving the balance between cushioning properties during toothbrushing and ease of spread to teeth and gums. As a result, they have newly discovered that by controlling the ingredients of an oral composition and using the residual rate when wet as an indicator, it is possible to impart suitable cushioning properties to the surfaces of teeth and gums during toothbrushing, improve the ease of spread of the oral composition to teeth and gums, and achieve a favorable balance between these effects. Here, the residual rate when wet is considered to be an indicator that combines the proportion of the oral composition that disperses or dissolves in water and the proportion of the oral composition that encapsulates or swells in water upon contact with water. In this embodiment, by controlling the residual rate when wet of an oral composition containing a combination of an abrasive and a binder, it is possible to achieve a good balance between cushioning properties during toothbrushing and ease of spread of the oral composition to teeth and gums. This also makes it possible to obtain an oral composition that provides a good feel when used in the oral cavity. For example, when the oral composition is used with a toothbrush, it is possible to reduce the irritation while still providing a moderate massaging sensation with the toothbrush.

[0014] The residual rate when hydrated is 60% or more, preferably 100% or more, more preferably 110% or more, and even more preferably 120% or more. This improves cushioning properties during tooth brushing. Furthermore, in order to improve the ease with which the oral composition spreads over the teeth and gums, the residual rate when hydrated is 180% or less, preferably 170% or less, more preferably 150% or less, and even more preferably 135% or less. This can, for example, prevent uneven distribution of the oral composition in the oral cavity, making it easier to spread evenly and improving its durability in the oral cavity. Here, the residual rate when hydrated is an index that includes oral compositions that encapsulate water or swell in water, as described above, and can therefore be a value exceeding 100% for oral compositions that swell significantly when hydrated.

[0015] Next, the components of the oral composition will be described. As described above, the oral composition contains an abrasive and a binder.

[0016] (Abrasive) Examples of the abrasive include one or more selected from the group consisting of abrasive silica such as hydrous silicic acid (e.g., gel silica, precipitated silica), anhydrous silicic acid, silica gel, and aluminosilicate; zeolite; calcium phosphate-based abrasives such as calcium hydrogen phosphate anhydrate, calcium hydrogen phosphate dihydrate, and calcium pyrophosphate; calcium carbonate-based abrasives such as calcium carbonate; and other inorganic abrasives such as aluminum hydroxide, alumina, magnesium carbonate, tribasic magnesium phosphate, zirconium silicate, tribasic calcium phosphate, hydroxyapatite, and quaternary calcium phosphate; and organic abrasives such as synthetic resin-based abrasives.

[0017] The abrasive preferably contains abrasive silica, more preferably contains hydrated silicic acid. It is also preferable to contain anhydrous silicic acid. This can more stably improve the balance between cushioning properties during tooth brushing and the ease of spreading the oral composition on teeth and gums. The abrasive silica may be either crystalline silica or amorphous silica, or may be wet silica.

[0018] The average particle size of the abrasive silica is preferably 1 μm or more, more preferably 2 μm or more, even more preferably 3 μm or more, and even more preferably 5 μm or more. This allows for efficient removal of stains from the tooth surface. The average particle size of the abrasive silica is also preferably 50 μm or less, more preferably 30 μm or less, and even more preferably 20 μm or less. This allows for a smooth mouthfeel to be obtained in an oral composition.

[0019] Here, the average particle size of the abrasive silica and the thickening silica described below is determined by measuring the particle size distribution of the particles on a volume basis using a commercially available laser diffraction / scattering particle size distribution measuring device. 50 It can be said that:

[0020] It is also preferable that the abrasive is substantially free of calcium carbonate. This allows for a more stable improvement in the balance between cushioning properties during toothbrushing and ease of application of the oral composition to the teeth and gums. Here, "the oral composition is free of calcium carbonate" specifically means that calcium carbonate is not intentionally blended into the oral composition, and more specifically means that the calcium carbonate content is 0.001% by mass or less of the oral composition as a whole.

[0021] The content of the abrasive in the oral composition is preferably 5% by mass or more, more preferably more than 5% by mass, even more preferably 10% by mass or more, even more preferably more than 10% by mass, even more preferably 11% by mass or more, and even more preferably 13% by mass or more, based on the total oral composition. This allows for efficient removal of stains from the tooth surface. Furthermore, the content of the abrasive in the oral composition is preferably 30% by mass or less, more preferably less than 30% by mass, even more preferably 25% by mass or less, and even more preferably 20% by mass or less, based on the total oral composition. This allows for an oral composition with excellent smoothness in use.

[0022] (Binder) Examples of the binder include at least one selected from the group consisting of thickening silica such as hydrous silicic acid (e.g., gel silica, precipitated silica) and anhydrous silicic acid (e.g., gel silica, precipitated silica, and dry silica); other inorganic binders such as bentonite; and organic binders such as pullulan, gelatin, methylcellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose and salts thereof, carrageenan, alginic acid and salts thereof, xanthan gum, polyacrylic acid and salts thereof, gum arabic, guar gum, locust bean gum, polyvinyl alcohol, and carboxyvinyl polymers. Specific examples of the salts include alkali metal salts such as sodium salts and potassium salts.

[0023] The binder preferably includes an inorganic binder, and more preferably includes thickening silica, which can more stably improve the balance between cushioning properties during tooth brushing and ease of spreading of the oral composition over the teeth and gums.

[0024] The thickening silica may be either crystalline silica or amorphous silica, and may be either dry silica or wet silica.The average particle size of the thickening silica is preferably 1 μm or more, more preferably 2 μm or more, even more preferably 5 μm or more, and even more preferably 10 μm or more.This allows the viscosity of the oral composition to be maintained more efficiently.In addition, the average particle size of the thickening silica is preferably 60 μm or less, more preferably 50 μm or less, and even more preferably 40 μm or less.This allows the oral composition to have excellent smoothness when used.

[0025] The oil absorption of the thickening silica, as determined by the amount of boiled linseed oil absorbed according to the method described in JIS K 5101-13-2 (2004), is, for example, 0.1 mL / g or more, preferably 0.2 mL / g or more, and, for example, 5 mL / g or less, preferably 4 mL / g or less.

[0026] The content of the inorganic binder in the oral composition is preferably 2% by mass or more, more preferably 2.5% by mass or more, even more preferably 3% by mass or more, and even more preferably 4% by mass or more, based on the total oral composition. This makes it possible to obtain an oral composition with excellent cushioning properties during toothbrushing. This also reduces irritation caused by contact of the toothbrush with the teeth, gums, etc. Furthermore, the content of the inorganic binder in the oral composition is preferably 30% by mass or less, more preferably 25% by mass or less, even more preferably 20% by mass or less, and even more preferably 15% by mass or less, based on the total oral composition. This makes it possible to obtain an oral composition with excellent surface smoothness.

[0027] The binder preferably contains an organic binder. When the binder contains thickening silica, it is preferable that the binder further contains an organic binder. This makes it possible to more stably improve the balance between cushioning properties during tooth brushing and ease of spreading of the oral composition over the teeth and gums.

[0028] In view of the above, the organic binder preferably comprises one or more selected from the group consisting of carboxymethylcellulose and its salts (e.g., sodium carboxymethylcellulose), xanthan gum, alginic acid and its salts (e.g., sodium alginate), polyacrylic acid and its salts, carboxyvinyl polymer, hydroxyethyl cellulose, hydroxypropyl cellulose, pectin, tragacanth gum, gum arabic, guar gum, karaya gum, locust bean gum, gellan gum, tamarind gum, psyllium seed gum, polyvinyl alcohol, and carrageenan (preferably excluding κ-carrageenan, e.g., ι-carrageenan); more preferably, it comprises one or more selected from the group consisting of carrageenan, sodium alginate, sodium carboxymethylcellulose, and xanthan gum; even more preferably, it comprises two or more selected from the group consisting of carrageenan, sodium alginate, sodium carboxymethylcellulose, and xanthan gum; still more preferably, it comprises sodium alginate or sodium carboxymethylcellulose and xanthan gum; and even more preferably, it comprises sodium alginate and xanthan gum. Specific examples of the salts include alkali metal salts such as sodium salts and potassium salts.

[0029] On the other hand, in terms of facilitating rinsing the oral cavity, it is also preferable that the oral composition does not contain xanthan gum. Specifically, the oral composition not containing xanthan gum means that xanthan gum is not intentionally blended into the oral composition, and more specifically, the content of xanthan gum is 0.001% by mass or less of the entire oral composition.

[0030] The content of the organic binder in the oral composition is preferably 0.2% by mass or more, more preferably 0.3% by mass or more, and even more preferably 1% by mass or more, based on the total oral composition. This allows the oral composition to have an appropriate viscosity. Furthermore, the content of the organic binder in the oral composition is preferably 15% by mass or less, more preferably 12% by mass or less, even more preferably 11% by mass or less, and even more preferably 10% by mass or less, based on the total oral composition. This allows the oral composition to be squeezed smoothly out of a tube container when filled in the tube.

[0031] The mass ratio of the organic binder content to the inorganic binder content in the oral composition (organic binder / inorganic binder) is preferably 0.05 or more, more preferably 0.1 or more, and even more preferably 0.2 or more. This makes it possible to obtain an oral composition that is smooth to the touch and has an excellent usability. Furthermore, the mass ratio (organic binder / inorganic binder) is preferably 2.0 or less, more preferably 1.75 or less, even more preferably 1.5 or less, even more preferably 1.25 or less, and even more preferably 0.9 or less. This makes it possible to obtain an oral composition that is easy to dispense from a container such as a tube container onto a toothbrush or the like.

[0032] The total content of binders in the oral composition is preferably 2% by mass or more, more preferably 3% by mass or more, and even more preferably 5% by mass or more, based on the total oral composition. This allows for the oral composition to have an appropriate viscosity. Furthermore, the total content of binders in the oral composition is, for example, 45% by mass or less, preferably 15% by mass or less, more preferably 12% by mass or less, even more preferably 11% by mass or less, and even more preferably 10% by mass or less, based on the total oral composition. This allows for an oral composition that is more easily absorbed by saliva during tooth brushing. Furthermore, excessive thickening of the oral composition can be suppressed.

[0033] The total content of silica in the oral composition is preferably 10% by mass or more, more preferably 15% by mass or more, and even more preferably 20% by mass or more, based on the total oral composition. This allows the fluidity of the oral composition to be moderately suppressed. The total content of silica in the oral composition is, for example, 60% by mass or less, preferably 30% by mass or less, more preferably 27.5% by mass or less, and even more preferably 25% by mass or less, based on the total oral composition. This allows the oral composition to be more easily mixed with saliva in the oral cavity, for example, when brushing teeth.

[0034] (Other Components) The oral composition may further contain components other than those described above. Such components include medicinal ingredients, thickeners, surfactants, humectants, flavoring agents, preservatives, fragrances, colorants, pH adjusters, solvents, solubilizers, bases, detergents, adsorbents, etc., and may be selected appropriately depending on the dosage form.

[0035] Examples of medicinal ingredients include one or more selected from the group consisting of bactericides, anti-inflammatory agents, blood circulation promoters, tartar inhibitors, stain removers, anti-hypersensitivity agents, vitamins, and plaque-decomposing enzymes. These medicinal ingredients are not limited as long as they can be used in pharmaceuticals, etc.

[0036] Among the medicinal ingredients, examples of disinfectants include one or more selected from the group consisting of isopropylmethylphenol, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, hinokitiol, chlorhexidine hydrochloride, alkyldiaminoethylglycine hydrochloride, sodium lauroyl sarcosine, and triclosan.

[0037] Examples of anti-inflammatory agents include one or more selected from the group consisting of tranexamic acid, β-glycyrrhetinic acid, glycyrrhetinic acid, glycyrrhizinic acid, diammonium glycyrrhizinate, disodium glycyrrhizinate, trisodium glycyrrhizinate, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, stearyl glycyrrhetinate, ε-aminocaproic acid, sodium azulene sulfonate hydrate, allantoin, allantoin dihydroxyaluminum, epidihydrocholesterol, dihydrocholesterol, and lysozyme hydrochloride.

[0038] Examples of the blood circulation promoter include one or more selected from the group consisting of sodium chloride, tocopherol acetate, sodium bicarbonate, sodium hydrogen carbonate, and tocopherol nicotinate.

[0039] Examples of tartar deposit inhibitors include one or more selected from the group consisting of disodium hydrogen phosphate, disodium dihydrogen pyrophosphate, sodium pyrophosphate, anhydrous sodium pyrophosphate, tetrasodium pyrophosphate (anhydrous), disodium monohydrogen phosphate, sodium hydrogen phosphate hydrate, disodium hydrogen phosphate (crystalline), trisodium phosphate, and sodium polyphosphate.

[0040] Examples of stain removers include one or more selected from the group consisting of macrogol (Macrogol 200, Macrogol 300, Macrogol 400, Macrogol 600, Macrogol 1000, Macrogol 1500, Macrogol 1540, Macrogol 4000, Macrogol 6000, Macrogol 20000, etc.), sodium polyphosphate, and polyvinylpyrrolidone.

[0041] The dentin hypersensitivity reducing agent may be, for example, at least one selected from the group consisting of potassium nitrate and water-soluble aluminum salts.

[0042] Examples of vitamin preparations include one or more selected from the group consisting of vitamin C and derivatives thereof, such as ascorbic acid, L-ascorbic acid, sodium ascorbate, sodium L-ascorbate, magnesium L-ascorbyl phosphate, pyridoxine hydrochloride, L-ascorbic acid 2-glucoside, ascorbyl tetra-2-hexyldecanoate, trisodium ascorbyl palmitate phosphate, 3-O-ethyl ascorbic acid, tocopherol, disodium isostearyl ascorbyl phosphate, and caprylyl 2-glyceryl ascorbate; and vitamin E and derivatives thereof, such as DL-α-tocopherol acetate, tocopherol acetate, dl-α-tocopherol nicotinate, and tocopherol nicotinate.

[0043] An example of a plaque decomposing enzyme is dextranase.

[0044] The thickening agent may be, for example, a commercially available thickening agent used as a raw material for pharmaceuticals, foods, or cosmetics. The thickening agent may include, for example, one or more selected from the group consisting of polyhydric alcohols, more specifically, sorbitol (sorbite), glycerin, concentrated glycerin, diglycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, propanediol (1,3-propanediol), polyethylene glycol, polypropylene glycol, xylitol, maltite, lactite, trehalose, sodium hyaluronate, and hydrolyzed collagen.

[0045] Examples of surfactants include anionic surfactants such as N-acylamino acid salts, α-olefin sulfonates, N-acylsulfonates, alkyl sulfates (e.g., sodium lauryl sulfate), and sulfates of glycerin fatty acid esters; nonionic surfactants such as polyoxyethylene alkyl ethers, polyoxyethylene-polyoxypropylene block copolymers, polyoxyethylene hydrogenated castor oil, polyoxyethylene ethers of glycerin esters, sucrose fatty acid esters, alkylolamides, and glycerin fatty acid esters; and amphoteric surfactants such as alkyl betaine surfactants (e.g., coconut oil fatty acid amido alkyl betaine), amine oxide surfactants, and imidazolinium betaine surfactants (e.g., 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine). The surfactant may also be a foaming agent.

[0046] The content of the surfactant in the oral composition is preferably 0.1% by mass or more, more preferably 0.5% by mass or more, and even more preferably 1% by mass or more, based on the total oral composition. This allows for an oral composition that foams appropriately when brushing teeth. Furthermore, the content of the surfactant in the oral composition is preferably 5% by mass or less, more preferably 3% by mass or less, and even more preferably 2% by mass or less, based on the total oral composition. This allows for an oral composition with cleansing power that does not excessively remove oil from the oral cavity.

[0047] The oral composition preferably further contains a humectant, which can improve the production stability of the oral composition. The humectant may be any humectant that is commercially available as a pharmaceutical, food, or cosmetic ingredient, such as a polyhydric alcohol, and more specifically, one or more selected from the group consisting of sorbitol (sorbitol), glycerin, concentrated glycerin, diglycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, propanediol (1,3-propanediol), polyethylene glycol, polypropylene glycol, sodium hyaluronate, and hydrolyzed collagen.

[0048] In terms of reducing irritation to the oral cavity, the humectant is preferably at least one selected from the group consisting of sorbitol, concentrated glycerin, and propylene glycol, more preferably sorbitol or concentrated glycerin.

[0049] The content of the humectant in the oral composition is preferably 5% by mass or more, more preferably 10% by mass or more, and even more preferably 20% by mass or more, based on the total oral composition. This allows for an oral composition with excellent moisturizing ability in the oral cavity. Furthermore, the content of the humectant in the oral composition is preferably 50% by mass or less, more preferably 45% by mass or less, and even more preferably 40% by mass or less, based on the total oral composition. This allows for an oral composition that is easy to rinse off with gargle.

[0050] Examples of flavoring agents include one or more selected from the group consisting of sodium L-glutamate, saccharin, saccharin sodium, sucrose, glucose, fructose, lactose, honey, aspartame, stevia, sucralose, inositol, D-sorbitol, D-mannitol, arabitol, raffinose, lactulose, lactitol, xylitol, erythritol, reduced palatinose, palatinose, Palatinit (registered trademark), acesulfame K, trehalose, maltose, maltosyltrehalose, or maltitol, neohesperidin dihydrochalcone, perillartine, p-methoxycinnamic aldehyde, and thaumatin.

[0051] The flavoring agent is preferably at least one selected from the group consisting of xylitol, saccharin sodium, and saccharin, and more preferably at least one selected from the group consisting of xylitol and saccharin sodium, since it has a strong sweetness and can adjust the taste even with a small amount.

[0052] Examples of preservatives include one or more selected from the group consisting of paraoxybenzoic acid esters such as sodium benzoate, methylparaben, ethylparaben, butylparaben, isopropylparaben, propylparaben, isobutylparaben, and benzylparaben; alcohols such as phenoxyethanol; sorbic acid, benzoic acid, dehydroacetic acid, propionic acid, and salts thereof; ethylenediaminetetraacetate, alkyldiaminoethylglycine hydrochloride, and ethylhexylglycerin. Specific examples of the above salts include alkali metal salts such as sodium salts and potassium salts; and alkaline earth metal salts such as calcium salts and magnesium salts.

[0053] The flavoring agent may be, for example, one or more selected from the group consisting of L-menthol, peppermint, spearmint, fruit flavorings, and peppermint oil.

[0054] Examples of coloring agents include one or more selected from the group consisting of natural dyes such as safflower red dye, gardenia yellow dye, gardenia blue dye, perilla dye, red koji dye, red cabbage dye, carrot dye, hibiscus dye, cacao dye, spirulina blue dye, and tamarind dye; legally mandated dyes such as Red No. 3, Red No. 104, Red No. 105, Red No. 106, Yellow No. 4, Yellow No. 5, Green No. 3, and Blue No. 1; riboflavin, and titanium dioxide.

[0055] Examples of pH adjusters include one or more selected from the group consisting of acids and alkalis, such as acetic acid, hydrochloric acid, sulfuric acid, nitric acid, citric acid, phosphoric acid, malic acid, gluconic acid, maleic acid, succinic acid, glutamic acid, pyrophosphoric acid, tartaric acid, sodium hydroxide, potassium hydroxide, sodium acetate, sodium carbonate, sodium citrate, sodium hydrogen citrate, phosphoric acid, sodium phosphate, sodium monohydrogen phosphate, sodium dihydrogen phosphate, and potassium dihydrogen phosphate, and buffers.

[0056] The solvent may be water, or a lower alcohol such as ethanol, propanol, etc. The solvent may be a liquid base.

[0057] The content of water in the oral composition can be, for example, the remainder after excluding components other than water from the oral composition. The content of water in the oral composition can be, for example, 30 to 80% by mass, and preferably 32 to 70% by mass, based on the total oral composition. It is also preferable that the oral composition does not contain ethanol, i.e., the ethanol content is 0% by mass, or that the oral composition contains ethanol but the ethanol content is 5% by mass or less. This can suppress strong irritation to the oral cavity.

[0058] A solubilizer may be added to promote the dissolution of the additives and medicinal ingredients in water. Examples of such solubilizers include polyhydric alcohols such as dipropylene glycol.

[0059] Other bases include, for example, sodium bicarbonate.

[0060] Detergents include, for example, sodium polyphosphate.

[0061] The adsorbent may be, for example, β-cyclodextrin.

[0062] Furthermore, in addition to the above components, components generally suitable for use in oral compositions can also be appropriately blended within the scope of the present invention.

[0063] (Dosage form, etc.) Specific examples of oral compositions include dentifrices such as toothpaste. The oral composition is preferably a dentifrice composition, more preferably a toothpaste composition. This can further improve the ease of handling of the oral composition. From the same point of view, the oral composition is preferably in the form of a paste or gel.

[0064] The oral composition is preferably applied to the oral cavity by being placed on a toothbrush. Examples of toothbrushes that can be used with the oral composition include known toothbrushes. A typical commercially available toothbrush can be used with the oral composition.

[0065] (Manufacturing Method) In this embodiment, the oral composition includes a step of blending, for example, an abrasive, a binder, and other appropriate ingredients. To obtain an oral composition with a water retention rate within a specific range, it is important to appropriately select the ingredients and blending ratios contained in the oral composition and to appropriately select the manufacturing process for the oral composition. For example, it is important to appropriately select and combine the types and amounts of abrasives and binders contained in the oral composition to design the blend. A combination of abrasive silica and an inorganic binder is preferred, and a combination of abrasive silica and a thickening silica is even more preferred. It is also preferable to further blend an organic binder into the oral composition. It is also preferable to further blend a humectant into the oral composition. It is also preferable to perform the manufacturing process for the oral composition under vacuum. For example, when the oral composition contains thickening silica, an organic binder, a humectant, and water, it is preferable to add the thickening silica, abrasives, and other appropriate ingredients during or after mixing the humectant, organic binder, and water, and stir and mix until uniform. It is also preferable to prepare a mixture of a part of the wetting agent and the organic binder in advance, add the mixture at the stage where the mixture has become homogeneous, and stir until the mixture is homogeneous. Furthermore, it is more preferable to carry out these steps under vacuum.

[0066] (Dentifrice) In this embodiment, the dentifrice is the above-mentioned oral composition filled in a tube container, preferably a toothpaste composition filled in a tube container. In this embodiment, the oral composition has an excellent balance between cushioning properties during toothbrushing and ease of spreading of the oral composition over the teeth and gums. By filling this into a tube container to make a dentifrice, for example, uneven distribution of the oral composition can be prevented and the oral composition can be easily spread to desired areas. Furthermore, the squeezed dentifrice prevents excessive irritation during toothbrushing and provides a pleasant feel when used, such as a pleasant cushioning sensation in the oral cavity.

[0067] Oral compositions such as toothpaste compositions are preferably filled in tube containers. Known containers can be used as the tube container. The material of the tube container can be one or more selected from the group consisting of resin materials such as polyethylene, polypropylene, polyethylene terephthalate, and nylon; and metal materials such as aluminum. For example, the tube container may be a single-layer or multi-layer container made of these materials. The material of the innermost layer of the container is preferably one or more selected from the group consisting of polyethylene, polypropylene, and polyethylene terephthalate. For example, an aluminum-laminated tube container may be used in which the innermost layer of the container is made of polyethylene and further includes an aluminum layer.

[0068] The inner diameter of the discharge port of the tube container is preferably 1 mm or more, more preferably 2 mm or more, and even more preferably 3 mm or more. This allows for more stable reduction of the excessive force required to discharge the oral composition. The inner diameter of the discharge port of the tube container is preferably 11 mm or less, more preferably 10 mm or less, and even more preferably 9 mm or less. This allows for efficient suppression of dripping. The length of the tube container excluding the discharge port may be approximately 50 to 160 mm, and the outer circumferential length of the tube container in the width direction may be approximately 20 to 120 mm.

[0069] Although the embodiments of the present invention have been described above, these are merely examples of the present invention, and various other configurations can also be adopted.

[0070] Hereinafter, the present embodiment will be specifically described with reference to examples and comparative examples, but the present embodiment is not limited to these examples.

[0071] (Examples 1 to 8, Comparative Examples 1 and 2) In these examples, oral compositions that are toothpaste compositions were prepared and evaluated. The formulations, measurements, and evaluation results for each example are shown in Tables 1 and 2. The formulations of each component in these tables are in mass %, and the particle size of silica is the average particle size. Details of the components listed in Tables 1 and 2 are also shown below. Sorbitol Kao: 70% sorbitol liquid, manufactured by Kao Corporation Cosmetic concentrated glycerin: concentrated glycerin, manufactured by Sakamoto Pharmaceutical Industry Co., Ltd. Sodium alginate SHG: sodium alginate, manufactured by Maikon no Kohara Co., Ltd. NIKKOL SLS: sodium lauryl sulfate, manufactured by Nikko Chemicals Co., Ltd. Caustic soda (48%): aqueous sodium hydroxide solution, manufactured by Tatsumi Synthetic Chemical Co., Ltd.

[0072] (Preparation of Oral Composition) Sorbitol or glycerin and purified water were weighed into a beaker, and an organic binder was gradually added while stirring at 2,500 rpm at 80° C. using an emulsifying / dispersing device (Labo-Lusion, manufactured by Primix Corporation) and a stirring section (Homodisper 2.5 type, manufactured by Primix Corporation). After stirring and mixing for 3 minutes, abrasive silica, thickening silica (oil absorption 2.5 mL / g), sodium lauryl sulfate, and caustic soda were added in that order, stirring and mixing with a rubber spatula each time until the mixture was uniform.

[0073] (Measurement of Residual Ratio When Wet) Using the method described in Method 1 above, the residual ratio when wet was measured at 25°C using the following procedure. (Method 1) 1. 2.0 g of each toothpaste composition and 10 g of water were weighed into a 30 mL beaker. The weighed amount [g] of the oral composition was recorded. 2. A stir bar was placed in the beaker, and the mixture was stirred on a magnetic stirrer at 120 rpm for 20 seconds. 3. After stirring, the contents of the beaker were transferred onto a nylon mesh with a pore size of 100 μm and allowed to stand for 30 seconds. After standing, no filtrate dripped from the nylon mesh. 4. The amount of residue [g] on the nylon mesh was weighed, and the residual ratio when wet was calculated using the following formula (1): Residual ratio when wet (%) = 100 * residue amount / weighed amount (1)

[0074] (Evaluation Method) Each toothpaste composition was filled into a tube, and the cushioning properties and ease of spreading to the teeth and gums were evaluated. The tube used was a laminated tube made of low-density polyethylene (LDPE) with an opening diameter of 19 mm and a size of 40Φ x 130H (40Φ One-Touch Tube-124.6, manufactured by Takemoto Container Co., Ltd.). The cap used was a one-touch cap made of polypropylene with an opening diameter of 6 mm and a size of 39Φ x 24H (T-40Φ One-Touch CAP II, manufactured by Takemoto Container Co., Ltd.).

[0075] (Cushioning) Three evaluators took a 1.5 cm length of each toothpaste composition and applied it to the entire teeth using a toothbrush (manufactured by Lion Corporation) with a head size of 18 mm and bristles made of saturated polyester resin. When applying, the softness of the toothbrush's contact with the gums and tooth surface was evaluated by consensus according to the following criteria, with A to C being considered acceptable. A: Feels soft to the touch B: Feels slightly soft to the touch C: Feels a slight change in the contact D: Does not feel soft at all

[0076] (Ease of Spreading to Teeth and Gums) A 1.5 cm length of each toothpaste composition was placed on the toothbrush, and three evaluators applied it to the entire teeth. The ease of spreading to the teeth and gums during application was evaluated by consensus according to the following criteria, with A and B being considered acceptable. A: Spreads easily to the entire teeth and gums. B: Feels like it has spread to the entire teeth and gums. C: Tends to remain locally in the mouth, making it difficult to spread to the entire teeth and gums. D: Tends to remain locally in the mouth, making it difficult to spread to the entire teeth and gums.

[0077]

[0078]

[0079] This application claims priority based on Japanese Patent Application No. 2024-116027, filed on July 19, 2024, the disclosure of which is incorporated herein by reference in its entirety.

Claims

1. An oral composition comprising an abrasive and a binder, the oral composition having a residual rate when wet of 60% or more and 180% or less, as measured by the following method 1. (Method 1) 1. Weigh out 2.0 g of the oral composition and 10 g of water into a 30 mL beaker. Record the amount (g) of the oral composition weighed.

2. Place a stirring bar in the beaker and stir on a magnetic stirrer at 120 rpm for 20 seconds.

3. After stirring, transfer the contents of the beaker onto a nylon mesh with a pore size of 100 μm and leave to stand for 30 seconds.

4. The amount of residue [g] on the nylon mesh is weighed, and the residual rate when wet is calculated based on the following formula (1): Residual rate when wet (%) = 100 * residue amount / weighed amount (1) 2. The oral composition of claim 1, wherein the binder comprises a thickening silica.

3. The oral composition of claim 1 or 2, wherein the binder comprises an organic binder.

4. The oral composition according to claim 3, wherein the organic binder is one or more selected from the group consisting of carboxymethyl cellulose and its salts, xanthan gum, alginic acid and its salts, polyacrylic acid and its salts, carboxyvinyl polymer, hydroxyethyl cellulose, hydroxypropyl cellulose, pectin, tragacanth gum, gum arabic, guar gum, karaya gum, locust bean gum, gellan gum, tamarind gum, psyllium seed gum, polyvinyl alcohol, and carrageenan (excluding κ-carrageenan).

5. An oral composition according to any one of claims 1 to 4, further comprising a humectant.

6. An oral composition according to any one of claims 1 to 5, wherein the abrasive comprises abrasive silica.

7. An oral composition according to any one of claims 1 to 6, which is a dentifrice composition.

8. An oral composition according to any one of claims 1 to 7, which is a toothpaste composition.

9. A dentifrice comprising the oral composition according to any one of claims 1 to 8 packed in a tube container.

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