Bilirubin adsorption column saturation detector and real-time bilirubin detection method

Abstract

The present application relates to the technical field of bilirubin adsorption therapy, and discloses a bilirubin adsorption column saturation detector and a real-time bilirubin detection method. The bilirubin adsorption column saturation detector comprises a light emitting device and a detection device; the light emitting device is provided with a first light emitting end and a second light emitting end; the detection device is provided with a first detection end and a second detection end; the first light emitting end is configured to allow light to pass through a blood plasma input tube of a bilirubin adsorption column and irradiate the first detection end, and the first detection end is used for detecting the light intensity of the light passing through the blood plasma input tube; the second light emitting end is configured to allow light to pass through a blood plasma output tube of the bilirubin adsorption column and irradiate the second detection end, and the second detection end is used for detecting the light intensity of the light passing through the blood plasma output tube. By means of the detector and the detection method, the saturation of an adsorption column can be more accurately detected in real time during the adsorption therapy of the adsorption column.

Description

Bilirubin adsorption column saturation detector and real-time bilirubin detection method TECHNICAL FIELD

[0001] The present application relates to the technical field of bilirubin adsorption treatment, in particular to a bilirubin adsorption column saturation detector and a real-time bilirubin detection method. BACKGROUND

[0002] Bilirubin is the main product of hemoglobin metabolism, and patients with severe hepatitis cannot metabolize bilirubin, which often develops into hyperbilirubinemia. Bilirubin adsorption is an important method for treating severe hepatitis hyperbilirubinemia. At present, various adsorption columns are applied in clinical practice, but there is no device in clinical practice that can detect the real-time saturation of the adsorption column during the process of bilirubin adsorption treatment. In actual operation, only the previous experience is relied on, and after about 3000-5000ml of plasma is adsorbed, saturation is reached. If the bilirubin adsorption column has not reached the saturation degree, the treatment will be ended, which will cause the waste of the adsorption material on the bilirubin adsorption column. If the bilirubin adsorption column has reached the saturation degree and the adsorption treatment is still continued, the adsorption effect of the adsorption column will be weakened, which will reduce the treatment effect on the patient and increase the treatment risk. Therefore, there is an urgent need for a bilirubin adsorption column saturation detector and a real-time bilirubin detection method that can more accurately and real-time detect the saturation of the adsorption column during the adsorption treatment of the adsorption column. SUMMARY

[0003] The purpose of the present application is to provide a bilirubin adsorption column saturation detector and a real-time bilirubin detection method to solve the problems existing in the prior art and to more accurately and real-time detect the saturation of the adsorption column during the adsorption treatment of the adsorption column.

[0004] To achieve the above-mentioned purpose, the present application provides the following solutions:

[0005] The present application provides a bilirubin adsorption column saturation detector, which comprises a light emitting device and a detection device. The light emitting device has a first light emitting end and a second light emitting end. The detection device has a first detection end and a second detection end. The first light emitting end is configured to make light pass through the plasma in the plasma input pipe of the bilirubin adsorption column and irradiate on the first detection end. The first detection end is used to detect the light intensity of the light passing through the plasma input pipe. The second light emitting end is configured to make light pass through the plasma in the plasma output pipe of the bilirubin adsorption column and irradiate on the second detection end. The second detection end is used to detect the light intensity of the light passing through the plasma output pipe.

[0006] Preferably, the first light-emitting end and the first detection end are oppositely arranged with a spacing, the second light-emitting end and the second detection end are oppositely arranged with a spacing, the plasma input tube is arranged to pass through between the first light-emitting end and the first detection end, and the plasma output tube is arranged to pass through between the second light-emitting end and the second detection end.

[0007] Preferably, the first light-emitting end and the first detection end are oppositely arranged with a spacing, the second light-emitting end and the second detection end are oppositely arranged with a spacing, the plasma input tube is arranged to pass through between the first light-emitting end and the first detection end, and the plasma output tube is arranged to pass through between the second light-emitting end and the second detection end.

[0008] Preferably, the first light-emitting end and the first detection end are oppositely arranged with a spacing, the second light-emitting end and the second detection end are oppositely arranged with a spacing, the plasma input tube is arranged to pass through between the first light-emitting end and the first detection end, and the plasma output tube is arranged to pass through between the second light-emitting end and the second detection end.

[0009] Preferably, the light-emitting device emits light with a wavelength of 430nm-490nm.

[0010] Preferably, the light-emitting device comprises a laser generator and two optical fibers, one end of each of the two optical fibers is connected to the output end of the laser generator, and the other end of each of the two optical fibers forms the first light-emitting end and the second light-emitting end.

[0011] Preferably, the detection device comprises a data processor and two detection heads, the two detection heads are signal-connected to the data processor, the two detection heads form the first detection end and the second detection end respectively, the two detection heads can detect the intensity of light passing through the plasma input tube and the plasma output tube respectively and transmit signals to the data processor, and the data processor can calculate the saturation of the hemin adsorption column according to the light intensity measured by the two detection heads.

[0012] Preferably, the detection device comprises a data processor and two detection heads, the two detection heads are signal-connected to the data processor, the two detection heads form the first detection end and the second detection end respectively, the two detection heads can detect the intensity of light passing through the plasma input tube and the plasma output tube respectively and transmit signals to the data processor, and the data processor can calculate the saturation of the hemin adsorption column according to the light intensity measured by the two detection heads.

[0013] The application also provides a real-time bilirubin detection method, comprising the following steps: turning on the light emitting device and the detection device, making the light emitted by the first light emitting end pass through the plasma input pipe and irradiate on the first detection end, making the light emitted by the second light emitting end pass through the plasma output pipe and irradiate on the second detection end, and calculating the saturation of the bilirubin adsorption column according to the ratio of the light intensity detected by the first detection end and the second detection end.

[0014] The application achieves the following technical effects relative to the prior art:

[0015] The bilirubin adsorption column saturation detector provided by the application can detect the light intensity after the light emitted by the first light emitting end passes through the plasma input pipe and irradiate on the first detection end, and the light intensity after the light emitted by the second light emitting end passes through the plasma output pipe and irradiate on the second detection end. During the bilirubin adsorption treatment, the first light emitting end, the first detection end, the second light emitting end and the second detection end are kept in an open state, and the staff can know the real-time saturation of the bilirubin in the adsorption column according to the light intensity obtained by the first detection end and the second detection end, so that the accurate detection of the saturation of the bilirubin in the adsorption column is realized. BRIEF DESCRIPTION OF DRAWINGS

[0016] In order to more clearly illustrate the technical solutions in the embodiments of the application or the prior art, the following will briefly introduce the drawings needed in the embodiments. Obviously, the drawings in the following description are only some embodiments of the application, and other drawings can be obtained by those skilled in the art without creative effort.

[0017] Fig. 1 is a structural schematic view of the bilirubin adsorption column saturation detector provided by the application;

[0018] In the figure: 1-light emitting device, 11-first light emitting end, 12-second light emitting end, 2-detection device, 21-first detection end, 22-second detection end, 3-first light shielding sleeve, 4-second light shielding sleeve, 5-plasma input pipe, 6-plasma output pipe, 7-bilirubin adsorption column, 8-optical fiber, 9-data processor. DETAILED DESCRIPTION

[0019] The technical solutions in the embodiments of the application will be described clearly and completely below with reference to the drawings in the embodiments of the application. Obviously, the described embodiments are only some of the embodiments of the application, not all. Based on the embodiments in the application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the application.

[0020] The purpose of the present application is to provide a bilirubin adsorption column saturation detector and a bilirubin real-time detection method to solve the problems of the prior art and to more accurately detect the saturation of the adsorption column in the adsorption treatment process.

[0021] In order to make the above-mentioned purposes, features and advantages of the present application more apparent and easy to understand, the present application will be further described in detail below with reference to the drawings and specific embodiments.

[0022] Embodiment one

[0023] The present embodiment provides a bilirubin adsorption column saturation detector, as shown in Figure 1, which comprises a light emitting device 1 and a detection device 2, the light emitting device 1 has a first light emitting end 11 and a second light emitting end 12, the detection device 2 has a first detection end 21 and a second detection end 22, the first light emitting end 11 is configured to make the light pass through the plasma in the plasma input pipe 5 of the bilirubin adsorption column 7 and irradiate on the first detection end 21, the first detection end 21 is used to detect the light intensity of the light passing through the plasma input pipe 5, the second light emitting end 12 is configured to make the light pass through the plasma in the plasma output pipe 6 of the bilirubin adsorption column 7 and irradiate on the second detection end 22, the second detection end 22 is used to detect the light intensity of the light passing through the plasma output pipe 6.

[0024] The bilirubin adsorption column saturation detector provided by the present embodiment, by adjusting the light emitting device 1, the first light emitting end 11 and the second light emitting end 12 emit light of the same intensity, the light emitted by the first light emitting end 11 passes through the plasma input pipe 5 of the bilirubin adsorption column 7 and irradiates on the first detection end 21, the first detection end 21 can detect the light intensity after the light passes through the plasma input pipe 5, the light emitted by the second light emitting end 12 passes through the plasma output pipe 6 of the bilirubin adsorption column 7 and irradiates on the second detection end 22, the second detection end 22 can detect the light intensity after the light passes through the plasma output pipe 6, during the bilirubin adsorption treatment process, the first light emitting end 11, the first detection end 21, the second light emitting end 12 and the second detection end 22 are turned on, and the staff can know the real-time saturation of bilirubin in the adsorption column according to the light intensity obtained by the first detection end 21 and the second detection end 22, since the light absorption capacity of bilirubin is proportional to its own concentration, the closer the values of the light intensity detected by the first detection end 21 and the second detection end 22, the higher the saturation of the bilirubin adsorption column 7, that is, the lower the adsorption capacity of the adsorption column to the plasma when the plasma passes through the adsorption column; the greater the difference between the values of the light intensity detected by the first detection end 21 and the second detection end 22, the lower the saturation of the bilirubin adsorption column 7, that is, the stronger the adsorption capacity of the adsorption column to the plasma when the plasma passes through the adsorption column, thereby realizing accurate detection of the saturation of bilirubin in the adsorption column.

[0025] In a preferred embodiment of the present application, the first light emitting end 11 and the first detection end 21 are oppositely arranged with a space, the second light emitting end 12 and the second detection end 22 are oppositely arranged with a space, the plasma input pipe 5 is arranged between the first light emitting end 11 and the first detection end 21, and the plasma output pipe 6 is arranged between the second light emitting end 12 and the second detection end 22. The first light emitting end 11 and the first detection end 21 are oppositely arranged, and the second light emitting end 12 and the second detection end 22 are oppositely arranged, so that the light can pass through the plasma input pipe 5 and the plasma output pipe 6 and irradiate on the first detection end 21 and the second detection end 22, respectively.

[0026] In a preferred embodiment of the present application, the first light emitting end 11 and the first detection end 21 are oppositely arranged with a space, the second light emitting end 12 and the second detection end 22 are oppositely arranged with a space, the plasma input pipe 5 is arranged between the first light emitting end 11 and the first detection end 21, and the plasma output pipe 6 is arranged between the second light emitting end 12 and the second detection end 22. The first light emitting end 11 and the first detection end 21 are oppositely arranged, and the second light emitting end 12 and the second detection end 22 are oppositely arranged, so that the light can pass through the plasma input pipe 5 and the plasma output pipe 6 and irradiate on the first detection end 21 and the second detection end 22, respectively.

[0027] In a preferred embodiment of the present application, the first light emitting end 11 and the first detection end 21 are oppositely arranged with a space, the second light emitting end 12 and the second detection end 22 are oppositely arranged with a space, the plasma input pipe 5 is arranged between the first light emitting end 11 and the first detection end 21, and the plasma output pipe 6 is arranged between the second light emitting end 12 and the second detection end 22. The first light emitting end 11 and the first detection end 21 are oppositely arranged, and the second light emitting end 12 and the second detection end 22 are oppositely arranged, so that the light can pass through the plasma input pipe 5 and the plasma output pipe 6 and irradiate on the first detection end 21 and the second detection end 22, respectively.

[0028] In a preferred embodiment of the present application, the wavelength of the light emitted by the light emitting device 1 is 430nm-490nm. The bilirubin in the plasma has good absorption capacity for light with a wavelength of 430nm-490nm, and using light with a wavelength in this range to irradiate the bilirubin can make the light be well absorbed, making the detection result more accurate. Among them, the bilirubin in the plasma has the best absorption capacity for light with a wavelength of 450nm.

[0029] In a preferred embodiment of the present application, the light emitting device 1 comprises a laser generator and two optical fibers 8, one end of each of the two optical fibers 8 is connected to the output end of the laser generator, and the other end of each of the two optical fibers 8 forms the first light emitting end 11 and the second light emitting end 12, respectively. The wavelength and frequency of the laser are stable, which can improve the accuracy of detection. In addition to directly using the laser generator to emit light of the corresponding wavelength, other forms of light sources can also be used, and the light is passed through an optical filter so that the light irradiated on the plasma input pipe 5 or the plasma output pipe 6 is of the corresponding wavelength. The optical filter is preferably a 450 nm optical filter.

[0030] In order to improve the processing speed of the detection result, in a preferred embodiment of the present application, the detection device 2 comprises a data processor 9 and two detection heads, the two detection heads are signal connected to the data processor 9, and the two detection heads form the first detection end 21 and the second detection end 22, respectively. The two detection heads can detect the intensity of the light passing through the plasma input pipe 5 and the plasma output pipe 6 and transmit the signal to the data processor 9, and the data processor 9 can calculate the saturation of the bilirubin adsorption column 7 according to the light intensity detected by the two detection heads.

[0031] In a preferred embodiment of the present application, a plurality of indicator lights are further included, the data processor is in communication connection with the indicator lights, different indicator lights are used to indicate different saturations, and the data processor 9 controls the corresponding indicator light to be turned on according to the saturation of the bilirubin adsorption column 7. By setting the indicator light, the staff can more intuitively understand whether the bilirubin in the adsorption column is saturated, and the convenience of using the detection instrument is improved.

[0032] Embodiment two

[0033] The present application provides a real-time bilirubin detection method, which comprises the following steps: turning on the light emitting device 1 and the detection device 2, making the light emitted by the first light emitting end 11 pass through the plasma input pipe 5 and irradiate on the first detection end 21, and making the light emitted by the second light emitting end 12 pass through the plasma output pipe 6 and irradiate on the second detection end 22, and calculating the saturation of the bilirubin adsorption column 7 according to the ratio of the light intensity detected by the first detection end 21 and the second detection end 22.

[0034] The bilirubin real-time detection method provided by the embodiment can help the staff to know the real-time saturation of the bilirubin in the adsorption column according to the light intensity obtained by the first detection end 21 and the second detection end 22 during the process of bilirubin adsorption. The closer the values of the light intensity detected by the first detection end 21 and the second detection end 22, the higher the saturation of the bilirubin adsorption column 7. The greater the difference between the values of the light intensity detected by the first detection end 21 and the second detection end 22, the lower the saturation of the bilirubin adsorption column 7. Thus, the precise detection of the saturation of the bilirubin in the adsorption column is realized. During the process of bilirubin adsorption treatment using the adsorption column, the light emitting device 1 can be kept on all the time, or can be turned on once every 5 seconds to 1 minute.

[0035] The principles and implementation manners of the present application are described by using specific examples in the present application. The above embodiment is only used to help understand the method of the present application and its core idea. Meanwhile, for those skilled in the art, according to the idea of the present application, the specific implementation manners and application ranges will be changed. In conclusion, the content of the present specification should not be understood as the limitation of the present application.

Claims

1. A bilirubin adsorption column saturation detector, characterized by: The device comprises a light emitting device and a detecting device, the light emitting device has a first light emitting end and a second light emitting end, the detecting device has a first detecting end and a second detecting end, the first light emitting end is configured to make light pass through the plasma in the plasma input tube of the bilirubin adsorption column and irradiate on the first detecting end, the first detecting end is used to detect the light intensity of the light passing through the plasma input tube, the second light emitting end is configured to make light pass through the plasma in the plasma output tube of the bilirubin adsorption column and irradiate on the second detecting end, the second detecting end is used to detect the light intensity of the light passing through the plasma output tube.

2. The bilirubin adsorption column saturation detector according to claim 1, characterized in that: The first light emitting end is oppositely arranged with the first detecting end with a spacing, the second light emitting end is oppositely arranged with the second detecting end with a spacing, the plasma input tube is used to pass through between the first light emitting end and the first detecting end, and the plasma output tube is used to pass through between the second light emitting end and the second detecting end.

3. The bilirubin adsorption column saturation detector according to claim 2, characterized in that: The device further comprises a first light shielding sleeve and a second light shielding sleeve, the first light shielding sleeve is used to cover the plasma input tube, the second light shielding sleeve is used to cover the plasma output tube, the first light shielding sleeve and the second light shielding sleeve are oppositely arranged with two through holes, the first light emitting end and the first detecting end respectively extend into the two through holes of the first light shielding sleeve, and the second light emitting end and the second detecting end respectively extend into the two through holes of the second light shielding sleeve.

4. The bilirubin adsorption column saturation detector according to claim 2, characterized in that: The device further comprises a first light shielding sleeve and a second light shielding sleeve, the first light shielding sleeve is used to cover the plasma input tube, the second light shielding sleeve is used to cover the plasma output tube, the first light shielding sleeve and the second light shielding sleeve are oppositely arranged with two through holes, the first light emitting end and the first detecting end respectively extend into the two through holes of the first light shielding sleeve, and the second light emitting end and the second detecting end respectively extend into the two through holes of the second light shielding sleeve.

5. The bilirubin adsorption column saturation detector according to claim 1, characterized in that: The wavelength of the light emitted by the light emitting device is 430nm-490nm.

6. The bilirubin adsorption column saturation detector according to claim 1, characterized in that: The light emitting device comprises a laser generator and two optical fibers, one end of each of the two optical fibers is connected with the output end of the laser generator, and the other end of each of the two optical fibers forms the first light emitting end and the second light emitting end.

7. The bilirubin adsorption column saturation detector according to claim 1, characterized in that: The detecting device comprises a data processor and two detecting heads, the two detecting heads are signal connected with the data processor, the two detecting heads respectively form the first detecting end and the second detecting end, the two detecting heads can respectively detect the intensity of the light passing through the plasma input tube and the plasma output tube and transmit signals to the data processor, and the data processor can calculate the saturation of the bilirubin adsorption column according to the light intensity detected by the two detecting heads.

8. The bilirubin adsorption column saturation detector according to claim 7, characterized in that: The device further comprises a plurality of indicator lights, the data processor is communicatively connected with the indicator lights, different indicator lights are used to indicate different saturations, and the data processor controls the corresponding indicator light to be turned on according to the saturation of the bilirubin adsorption column.

9. A method for real-time detection of bilirubin, characterized by: The device comprises the following steps: The light emitting device and the detecting device are turned on, the light emitted by the first light emitting end passes through the plasma input tube and irradiates on the first detecting end, the light emitted by the second light emitting end passes through the plasma output tube and irradiates on the second detecting end, and the saturation of the bilirubin adsorption column is calculated according to the ratio of the light intensity detected by the first detecting end and the second detecting end.

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