The invention provides a safe fastening structure for a municipal road direction board. The safe fastening structure comprises a fixing rack (9) and a direction board bracket (8), wherein the interior of a vertical post (92) of the fixing rack (9) is provided with a clamping groove (920) composed of an upper clamping part (921), a middle slope transition part (922) and a lower wide-opening part (923) which are arranged in the sequence from top to bottom, a clamp head (91) is arranged on the end part of the left side of a horizontal cross bar (82) of the direction board bracket (8), passes through the vertical post (92) from the lower wide-opening part (923), and can move upwards in the clamping groove (920) till reaching the upper clamping part (921), so that the clamp head (91) is blocked in the axial direction of the horizontal cross bar (82), and the locating is realized in the front and back direction orthotropic to the axial direction of the horizontal cross bar (82).