Hot cover device and nucleic acid detection equipment

Abstract

The present invention relates to a thermal cover device and a nucleic acid detection device, wherein the thermal cover device comprises: a mounting seat; a thermal cover assembly, which is rotatably connected to the mounting seat around a rotating shaft extending in a first direction, and the thermal cover assembly has a heating chamber with an opening at one end; a lifting drive member, which is transmission-connected to the thermal cover assembly, and the lifting drive member is used to drive the thermal cover assembly to move back and forth in a straight line along the first direction. The thermal cover device drives the thermal cover assembly to lift and lower in the first direction through the lifting drive member, so that the heating chamber of the thermal cover assembly covers the tube cover of the reaction tube to perform wrap-type heating on the tube cover, which increases the heating area compared to the prior art, thereby significantly improving the heating effect, effectively preventing the evaporated liquid from condensing on the tube cover, and ensuring the accuracy of the experimental results.

Description

Technical Field

[0001] The present invention relates to the technical field of molecular diagnosis, and in particular to a thermal cover device and nucleic acid detection equipment. Background Art

[0002] In the process of genetic testing, the sample to be tested needs to be placed in a reaction tube for amplification testing after lysis and purification, so as to achieve quantitative analysis of the DNA template. This process is of great significance to molecular biology research and medical research.

[0003] However, in the current amplification detection process, the reaction tube needs to be heated. The high temperature will evaporate the liquid in the reaction tube. The water vapor formed by the evaporation of the liquid condenses on the tube cover of the reaction tube, which will affect the accuracy of the experimental results. Therefore, a hot cover device for heating the tube cover of the reaction tube is widely used in various PCR detection instruments. The hot cover device heats the tube cover of the reaction tube to prevent the liquid in the reaction tube from condensing on the tube cover.

[0004] However, the existing hot cover device often controls the heating plate to heat the tube cover of the reaction tube by the torque output by the motor. The contact area between the heating plate and the tube cover of the reaction tube is small, and the heating effect is poor, which is difficult to meet the experimental requirements, thereby affecting the accuracy of the experimental results. Summary of the invention

[0005] Based on this, it is necessary to provide a thermal cover device and a nucleic acid detection device, which can achieve the technical effect of optimizing the heating method and improving the thermal cover effect.

[0006] According to one aspect of the present application, a thermal cover device is provided, the thermal cover device comprising:

[0007] Mounting seat;

[0008] A heat cover assembly is rotatably connected to the mounting seat around a rotation axis extending along a first direction, and the heat cover assembly has a heating chamber with an open end; and

[0009] The lifting drive member is drivingly connected to the thermal cover assembly, and the lifting drive member is used to drive the thermal cover assembly to reciprocate linearly along the first direction.

[0010] In one embodiment, the heat cover device includes a lifting and moving seat, which is movably connected to the mounting seat along the first direction, the lifting drive member is transmission-connected to the lifting and moving seat, and the heat cover assembly is rotatably mounted on the lifting and moving seat around the rotating shaft.

[0011] In one embodiment, the thermal cover device further comprises a rotating member, wherein the rotating member is matched with the mounting seat, and when the thermal cover assembly moves upward along the first direction, the rotating member pushes the thermal cover assembly to rotate around the rotating axis.

[0012] In one embodiment, the rotating member cooperates with the inclined surface of the thermal cover assembly, and the rotating member has a guide surface extending obliquely relative to the first direction; when the thermal cover assembly moves upward along the first direction, the guide surface slides in contact with the thermal cover assembly to push the thermal cover assembly to rotate around the rotating axis.

[0013] In one embodiment, the thermal cover assembly includes a connecting portion, the connecting portion includes a connecting portion body and a rotating fitting, the connecting portion body is rotatably connected to the mounting seat around the rotating axis, and the rotating fitting is protruded from the connecting portion body along a direction perpendicular to the first direction; when the thermal cover assembly moves upward along the first direction, the guide surface is in sliding contact with the rotating fitting.

[0014] In one embodiment, the rotating fitting includes a sliding bearing and a fixing pin, one end of the fixing pin is fixedly connected to the connecting part body, the other end of the fixing pin protrudes out of the connecting part body, and the sliding bearing is sleeved on the end of the fixing pin protruding out of the connecting part body.

[0015] In one embodiment, the thermal cover device further comprises a reset member, which is transmission-connected to the thermal cover assembly. When the thermal cover assembly moves downward along the first direction, the reset member drives the thermal cover assembly to rotate around the rotating shaft, and the rotation direction of the thermal cover assembly driven by the rotating member is opposite to the rotation direction driven by the reset member.

[0016] In one embodiment, one end of the reset member is fixedly connected to the mounting seat, and the other end of the reset member is connected to the thermal cover assembly. The reset member can generate a recoverable deformation to switch between an initial state and a stretched state.

[0017] In one embodiment, the thermal cover device further includes a rotation-stopping member. After the reset member drives the thermal cover assembly to rotate around the rotation axis to an extreme position, the rotation-stopping member abuts against the thermal cover assembly to prevent the thermal cover assembly from continuing to rotate.

[0018] According to one aspect of the present application, a nucleic acid detection device is provided, comprising the above-mentioned hot cover device.

[0019] The above-mentioned hot cover device drives the hot cover assembly to reciprocate and rise and fall in the first direction through the lifting drive member, so that the heating chamber of the hot cover assembly covers the tube cover of the reaction tube to perform wrapping heating on the tube cover. Compared with the prior art, the heating area is increased, thereby significantly improving the heating effect, effectively preventing the evaporated liquid from condensing on the tube cover, and ensuring the accuracy of the experimental results. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 It is a schematic structural diagram of a thermal cover device according to an embodiment of the present invention when it is in a heating state;

[0021] Figure 2 for Figure 1 A schematic structural diagram of the thermal cover device from another angle;

[0022] Figure 3 Schematic diagram of the structure of the thermal cover device according to one embodiment of the present invention when it is in a non-heating state.

[0023] Description of Figure Numbers:

[0024] 100, hot cover device; 10, mounting seat; 20, lifting guide rail; 30, lifting movable seat; 32, first movable part; 34, second movable part; 40, hot cover assembly; 41, connecting arm; 43, connecting part; 432, connecting part body; 434, rotating matching part; 4341, sliding bearing; 4343, fixing pin; 45, heating part; 50, lifting driving part; 52, driving part body; 54, transmission screw; 60, rotating part; 61, guide surface; 70, reset part; 81, first fixing pin; 83, second fixing pin; 90, anti-rotation part; 200, nucleic acid amplification device; 300, reaction tube. DETAILED DESCRIPTION

[0025] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the specific embodiments of the present invention are described in detail below in conjunction with the accompanying drawings. In the following description, many specific details are set forth to facilitate a full understanding of the present invention. However, the present invention can be implemented in many other ways different from those described herein, and those skilled in the art can make similar improvements without violating the connotation of the present invention, so the present invention is not limited by the specific embodiments disclosed below.

[0026] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise", "axial", "radial", "circumferential" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as limiting the present invention.

[0027] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include at least one of the features. In the description of the present invention, the meaning of "plurality" is at least two, such as two, three, etc., unless otherwise clearly and specifically defined.

[0028] In the present invention, unless otherwise clearly specified and limited, the terms "installed", "connected", "connected", "fixed" and the like should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements, unless otherwise clearly defined. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0029] In the present invention, unless otherwise clearly specified and limited, a first feature being "above" or "below" a second feature may mean that the first and second features are in direct contact, or the first and second features are in indirect contact through an intermediate medium. Moreover, a first feature being "above", "above" or "above" a second feature may mean that the first feature is directly above or obliquely above the second feature, or simply means that the first feature is higher in level than the second feature. A first feature being "below", "below" or "below" a second feature may mean that the first feature is directly below or obliquely below the second feature, or simply means that the first feature is lower in level than the second feature.

[0030] It should be noted that when an element is referred to as being "fixed to" or "disposed on" another element, it may be directly on the other element or there may be a central element. When an element is considered to be "connected to" another element, it may be directly connected to the other element or there may be a central element at the same time. The terms "vertical", "horizontal", "upper", "lower", "left", "right" and similar expressions used herein are for illustrative purposes only and do not represent the only implementation method.

[0031] Figure 1 A schematic diagram showing the structure of a thermal cover device in an embodiment of the present invention when it is in a heating state; Figure 2 A schematic structural diagram showing another angle of the heat cover device in one embodiment of the present invention when it is in a heating state; Figure 3 Schematic diagram of the structure of the thermal cover device according to one embodiment of the present invention when it is in a non-heating state.

[0032] See also Figures 1 to 3 An embodiment of the present invention provides a nucleic acid detection device, including a thermal cover device 100 and a nucleic acid amplification device 200. The thermal cover device 100 is arranged on one side of the nucleic acid amplification device 200, and the thermal cover device 100 is used to heat the tube cover of a reaction tube 300 inserted in the nucleic acid amplification device 200.

[0033] The hot cover device 100 includes a mounting seat 10, a hot cover assembly 40, a lifting drive 50, a rotating member 60 and a reset member 70. The mounting seat 10 plays a supporting and fixing role, and the hot cover assembly 40 can be rotatably connected to the mounting seat 10 around a rotating shaft extending along a first direction. The hot cover assembly 40 is provided with a heating chamber with an open end to perform wrap-type heating on the tube cover of the reaction tube 300. The lifting drive 50 is transmission-connected to the hot cover assembly 40, and the lifting drive 50 is used to drive the hot cover assembly 40 to reciprocate linearly along the first direction to switch between the first height and the second height, so as to approach or move away from the reaction tube 300 in the nucleic acid amplification device 200 in the first direction.

[0034] In this way, the lifting drive 50 drives the heat cover assembly 40 to lift and reciprocate in the first direction, so that the heating chamber of the heat cover assembly 40 covers the tube cover of the reaction tube 300 to perform wrap-type heating on the tube cover. Compared with the prior art, the heating area is increased, thereby significantly improving the heating effect, effectively preventing the evaporated liquid from condensing on the tube cover, and ensuring the accuracy of the experimental results.

[0035] Furthermore, the hot cover device 100 further includes a rotating member 60 and a resetting member 70. When the hot cover assembly 40 is in the process of being lifted or lowered, the rotating member 60 and the resetting member 70 can drive the hot cover assembly 40 to rotate around a rotating axis extending along a first direction to switch between a first angle and a second angle, thereby aligning or misaligning with the reaction tube 300 in the nucleic acid amplification device 200 in the first direction.

[0036] In this way, under the cooperation of the rotating member 60 and the reset member 70, the lifting drive member 50 drives the heat cover assembly 40 to lift and lower in the first direction to realize the lifting movement of the heat cover assembly 40 in the first direction and the rotation around the first direction. The two movements are combined to finally realize the wrapping heating of the tube cover of the reaction tube 300 by the heating chamber.

[0037] Specifically, in some embodiments, the mounting seat 10 is a long strip structure extending longitudinally along the first direction, and a lifting guide rail 20 extending longitudinally along the first direction is installed on one side of the mounting seat 10, and a lifting movable seat 30 movable along the first direction is connected to the lifting guide rail 20. The lifting movable seat 30 includes a first moving portion 32 and a second moving portion 34, the first moving portion 32 is connected to the lifting guide rail 20, and the second moving portion 34 is bent and extended from one end of the first moving portion 32 in a direction away from the lifting guide rail 20, and the second moving portion 34 is used to install the thermal cover assembly 40.

[0038] The lifting drive member 50 is arranged at intervals on one side of the mounting seat 10 where the lifting guide rail 20 is provided. The lifting drive member 50 is connected to the lifting movable seat 30 in a transmission manner, and is used to drive the lifting drive member 50 to move back and forth linearly along the first direction under the guidance of the lifting guide rail 20. Specifically, in some embodiments, the lifting drive member 50 is a screw motor, including a drive member body 52 and a transmission screw 54. The drive member body 52 is located on one side of the mounting seat 10, one end of the transmission screw 54 is connected to the drive member body 52, and the other end of the transmission screw 54 extends along the first direction and is connected to the second moving portion 34 of the lifting movable seat 30. In this way, the drive member body 52 can drive the transmission screw 54 to rotate, thereby driving the lifting movable seat 30 to move back and forth linearly along the lifting guide rail 20 in the first direction. It can be understood that the lifting drive member 50 can also be other driving components that can output torque, which is not limited here.

[0039] The heat cover assembly 40 includes a connecting arm 41, a connecting portion 43 and a heating portion 45. The connecting arm 41 is a long strip structure, and the connecting portion 43 and the heating portion 45 are respectively arranged at opposite ends of the connecting arm 41 in the length direction. The connecting portion 43 is rotatably mounted on the second movable portion 34 of the lifting movable seat 30 around a rotating shaft, and the connecting arm 41 extends out of the second movable portion 34 in a direction away from the mounting seat 10. The heating portion 45 is a cap-shaped structure, and is provided with a heating cavity with an open end. Part or all of the tube cover can be extended into the heating cavity from the open end of the heating cavity, so that the heating portion 45 can wrap the tube cover of the reaction tube 300 and heat the tube cover.

[0040] Thus, the heat cover assembly 40 can follow the lifting and moving seat 30 to move back and forth in a first direction to switch between a first height and a second height, and can rotate around the rotation axis under the action of an external force to switch between a first angle and a second angle.

[0041] It should be noted that in the following embodiments, the first height and the second height are the limit positions of the thermal cover assembly 40 in the first direction, wherein the first height is the lowest limit height of the thermal cover assembly 40 in the first direction, and the second height is the highest limit height of the thermal cover assembly 40 in the first direction, but does not limit the absolute height of the thermal cover assembly 40. The highest and lowest heights of the thermal cover assembly 40 in the first direction can be adjusted as needed to meet different requirements. Figure 1 In the embodiment, the second height is located above the first height, and the lifting and moving seat 30 can drive the heat cover assembly 40 at the first height to move upward to the second height, and can also drive the heat cover assembly 40 at the second height to move downward to the first height. Similarly, the first angle and the second angle are the limit positions of the heat cover assembly 40 in the circumferential direction, but do not limit the absolute position of the heat cover assembly 40 in the circumferential direction. The limit position of the heat cover assembly 40 in the circumferential direction can be adjusted as needed to meet different requirements. Figure 2 The angle of the medium heat cover assembly 40 in the circumferential direction is a first angle, Figure 3 The angle of the medium heat cover assembly 40 in the circumferential direction is a second angle.

[0042] Further, the connecting part 43 includes a connecting part body 432 and a rotating matching piece 434. The connecting part body 432 is roughly a hollow rotating body structure, and a bearing mounting hole for mounting a bearing is provided in the middle of the connecting part body 432 to install the bearing. In this way, the connecting part body 432 is rotatably mounted on the second moving part 34 of the lifting and moving seat 30 through the bearing, and the connecting part body 432 can rotate relative to the second moving part 34 around the rotating axis, and the rotating axis is the central axis of the bearing. The rotating matching piece 434 includes a sliding bearing 4341 and a fixing pin 4343, one end of the fixing pin 4343 is fixed to the side edge of the connecting part body 432, and the other end of the fixing pin 4343 protrudes from the connecting part body 432 along the radial direction of the connecting part body 432, and the sliding bearing 4341 is sleeved on one end of the fixing pin 4343 protruding from the connecting end. In this way, the rotating matching piece 434 is protruding from the edge of the connecting part body 432 in a direction perpendicular to the first direction to cooperate with the rotating piece 60.

[0043] The rotating member 60 is fixed to the top of the mounting seat 10 and is located on one side in the radial direction of the connecting portion 43 of the thermal cover assembly 40. The rotating member 60 has a guide surface 61 extending obliquely relative to the first direction. In the direction from bottom to top along the first direction, the distance between the guide surface 61 and the mounting seat 10 gradually decreases. Preferably, in some embodiments, the guide surface 61 is a 3D cam surface to adapt to the motion trajectory of the sliding bearing 4341.

[0044] In this way, the guide surface 61 is in sliding contact with the sliding bearing 4341 of the rotating matching member 434 and is matched with the inclined surface of the rotating matching member 434, thereby converting the relative linear motion of the thermal cover assembly 40 and the rotating member 60 in the first direction into the rotational motion of the thermal cover assembly 40 around the rotating axis. When the thermal cover assembly 40 moves upward along the first direction and switches from the first height to the second height, different positions of the guide surface 61 gradually contact with the connecting portion 43 from bottom to top, thereby pushing the connecting portion 43 to rotate around the rotating axis to switch from the first angle to the second angle. When the thermal cover assembly 40 moves downward along the first direction from the second height to the first height, the rotating matching member 434 moves downward relative to the rotating member 60 in the first direction and disengages from the rotating member 60.

[0045] The reset member 70 is a tension spring, one end of which is fixedly connected to the lifting and moving seat 30, and the other end of which is connected to the connecting portion 43. The reset member 70 can generate a restorable deformation to switch between the initial state and the stretched state. Specifically, in one embodiment, a first fixing pin 81 is protrudingly provided at one end of the second moving portion 34 of the lifting and moving seat 30 close to the mounting seat 10, and a second fixing pin 83 is protrudingly provided on the upper end surface of the rotating portion of the heat cover assembly 40, and the two ends of the reset member 70 are respectively connected to the first fixing pin 81 and the second fixing pin 83.

[0046] When the thermal cover assembly 40 is at the first angle, the reset member 70 is in the initial state, and at this time, the reset member 70 does not exert a pulling force on the thermal cover assembly 40. When the thermal cover assembly 40 is at the second angle, the reset member 70 is in a stretched state and exerts a pulling force on the thermal cover assembly 40 to try to drive the thermal cover assembly 40 to rotate and return to the second angle.

[0047] In this way, the reset member 70 is in transmission connection with the heat cover assembly 40. When the heat cover assembly 40 moves upward along the first direction and switches from the first height to the second height, the heat cover assembly 40 overcomes the force of the reset member 70 and rotates from the first angle to the second angle under the push of the rotating member 60. When the heat cover assembly 40 moves downward along the first direction and switches from the second height to the first height, the heat cover assembly 40 is separated from the rotating member 60, and the force resisting the reset member 70 disappears, so the reset member 70 switches from the stretched state to the initial state, thereby driving the heat cover assembly 40 to rotate from the second angle to the first angle.

[0048] In some embodiments, the heat cover device 100 further includes a stopper 90, which is disposed on a side edge of the lifting and moving seat 30 away from the rotating member 60. Specifically, in one embodiment, the stopper 90 is a protrusion disposed on an end of the second moving portion 34 away from the mounting seat 10 and away from the rotating member 60. When the heat cover assembly 40 switches from the second angle to the first angle, the stopper 90 abuts against the connecting arm 41 of the heat cover assembly 40 to prevent the heat cover assembly 40 from continuing to rotate, thereby keeping the heat cover assembly 40 at the first angle.

[0049] The working process of the above-mentioned hot cover device 100 is as follows:

[0050] When the tube cover of the reaction tube 300 is heated, the thermal cover assembly 40 is at a first height and a first angle, and the heating portion 45 of the thermal cover assembly 40 wraps the tube cover of the reaction tube 300 .

[0051] After the heating is completed, the lifting drive 50 drives the lifting seat 30 to move upward along the lifting guide rail 20 in the first direction, and the heat cover assembly 40 follows the lifting seat 30 to rise until it switches to the second height. In the process of switching the heat cover assembly 40 from the first height to the second height, the rotating fitting member 434 of the heat cover assembly 40 contacts the guide surface 61 of the rotating member 60. As the rotating fitting member 434 moves in the first direction, the rotating fitting member 434 overcomes the force of the reset member 70 under the push of the guide surface 61 and rotates around the rotating axis, so that the heat cover assembly 40 switches to the second angle to be misaligned with the reaction tube 300, so as to facilitate the removal of the reaction tube 300.

[0052] After the next reaction tube 300 is placed, the lifting drive 50 drives the lifting seat 30 to move downward along the lifting guide rail 20 in the first direction, and the heat cover assembly 40 follows the lifting seat 30 to descend to the first height. In the process of switching the heat cover assembly 40 from the second height to the first height, the rotating fitting 434 of the heat cover assembly 40 is disengaged from the guide surface 61, and then rotates in the opposite direction under the action of the reset member 70 until it abuts against the stop member 90. At this time, the heat cover assembly 40 switches to the first angle and aligns with the reaction tube 300. After that, the heat cover assembly 40 continues to descend under the drive of the lifting drive 50 until the tube cover extends into the heating chamber of the heating part 45 and is wrapped by the heating part, so that the tube cover of the reaction tube 300 can be wrapped and heated.

[0053] It can be understood that the above process is repeated in a cycle, so that the tube covers of multiple reaction tubes 300 can be heated in sequence.

[0054] The above-mentioned hot cover device 100 can realize the lifting and rotation of the hot cover assembly 40 by only controlling the working state of the lifting driving member 50, and then the tube cover of the reaction tube 300 is wrapped and heated by the cap-shaped heating part 45, thereby improving the heating effect and ensuring the accuracy of the experimental results. Moreover, since the above process can be realized only by driving the lifting driving member 50, the structure is simple and reliable, and the production cost is low.

[0055] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0056] The above-mentioned embodiments only express several implementation methods of the present invention, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the scope of the invention patent. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the present invention, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention shall be subject to the attached claims.

Claims

1. A thermal cover device, characterized in that: The thermal cover device comprises: Mounting seat; A heat cover assembly is rotatably connected to the mounting seat around a rotation axis extending along a first direction, wherein the heat cover assembly has a heating chamber with an opening at one end, and the heating chamber is used to cover the tube cover of the reaction tube; a lifting drive member, which is in driving connection with the thermal cover assembly, and is used to drive the thermal cover assembly to move back and forth in a linear manner along the first direction and to rotate about the first direction; and a rotating member, connected to the mounting seat, and when the thermal cover assembly moves upward along the first direction, the rotating member pushes the thermal cover assembly to rotate around the rotating shaft; The rotating member cooperates with the inclined surface of the thermal cover assembly, and the rotating member has a guide surface extending obliquely relative to the first direction; when the thermal cover assembly moves upward along the first direction, the guide surface slides in contact with the thermal cover assembly to push the thermal cover assembly to rotate around the rotating axis.

2. The thermal cover device according to claim 1, characterized in that: The heat cover device comprises a lifting movable seat, the lifting movable seat is movably connected to the mounting seat along the first direction, the lifting driving member is drivingly connected to the lifting movable seat, and the heat cover assembly is rotatably mounted on the lifting movable seat around the rotating shaft.

3. The thermal cover device according to claim 1, characterized in that: The thermal cover assembly includes a connecting portion, which includes a connecting portion body and a rotating fitting. The connecting portion body is rotatably connected to the mounting seat around the rotating axis, and the rotating fitting is protruded from the connecting portion body along a direction perpendicular to the first direction. When the thermal cover assembly moves upward along the first direction, the guide surface is in sliding contact with the rotating fitting.

4. The thermal cover device according to claim 3, characterized in that: The rotating fitting comprises a sliding bearing and a fixing pin, one end of the fixing pin is fixedly connected to the connecting part body, the other end of the fixing pin protrudes out of the connecting part body, and the sliding bearing is sleeved on the end of the fixing pin protruding out of the connecting part body.

5. The thermal cover device according to claim 1, characterized in that: The thermal cover device further comprises a reset member, which is transmission-connected to the thermal cover assembly. When the thermal cover assembly moves downward along the first direction, the reset member drives the thermal cover assembly to rotate around the rotating shaft, and the rotation direction of the thermal cover assembly driven by the rotating member is opposite to the rotation direction driven by the reset member.

6. The thermal cover device according to claim 5, characterized in that: One end of the reset member is fixedly connected to the mounting seat, and the other end of the reset member is connected to the thermal cover assembly. The reset member can generate a recoverable deformation to switch between an initial state and a stretched state.

7. The thermal cover device according to claim 5, characterized in that: The thermal cover device further comprises a rotation-stopping member. After the reset member drives the thermal cover assembly to rotate around the rotation axis to an extreme position, the rotation-stopping member abuts against the thermal cover assembly to prevent the thermal cover assembly from continuing to rotate.

8. A nucleic acid detection device, characterized in that: Comprising the hot cover device according to any one of claims 1 to 7.

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