Liquid medicine mixing device of filling machine

Abstract

The invention relates to the technical field of medicine mixing devices, and particularly discloses a filling machine liquid medicine mixing device which comprises a rack, a tank body arranged on the rack, a liquid adding pipe located in the center of the tank body and downwards penetrating into the tank body, a powder adding pipe arranged on one side of the tank body in an offset mode, a rotation driving mechanism driving the liquid adding pipe to rotate and a feeding mechanism located in the tank body. The feeding mechanism comprises a cover plate assembly, a sieve plate assembly and a driving assembly; the cover plate assembly is fixed in the tank body and is provided with a powder inlet; the screen plate assembly comprises screen plates which are distributed below the cover plate assembly at intervals and arranged outside the liquid adding pipe in a sleeving mode, the screen plates correspond to the powder inlet, and the screen plates and the liquid adding pipe are assembled together in a circumferential relative rotation stopping and up-down relative sliding mode; the driving assembly comprises an elastic part connected to the screen plate, a first abutting block arranged at the top of the screen plate assembly and a second abutting block arranged at the bottom of the cover plate assembly. According to the liquid medicine mixing device of the filling machine, a uniform and lump charging mode is realized.

Description

Technical Field

[0001] The invention relates to the technical field of medicine mixing devices, in particular to a medicine liquid mixing device for a perfusion machine. Background Art

[0002] Pharmaceutical production processes rely heavily on pharmaceutical equipment, whose performance and technical expertise directly impact a company's production capacity and product quality. Filling machines within pharmaceutical equipment precisely fill liquids, suspensions, or semisolids into pre-determined containers, ensuring the correct dosage in each container. Liquid medicines typically consist of multiple ingredients. Prior to filling, the weighed active ingredients and excipients must be dissolved in an appropriate solvent and thoroughly mixed to ensure uniform distribution of these ingredients throughout the final product, ensuring that each dosage unit contains the correct ratio of active and inactive ingredients.

[0003] A Chinese patent document with authorization publication number CN220125962U discloses a biopharmaceutical liquid mixing device. The biopharmaceutical liquid mixing device is equipped with a stirring blade at the bottom of a mixing cylinder, and the stirring blade is fit with the bottom of the mixing cylinder. Under the operation of a rotating motor, the stirring blade is driven to rotate at high speed, scooping up the solid powder deposited at the bottom and driving it to rotate. At the same time, the stirring rod and the stirring blade rotate in opposite directions, generating reverse water flow, strengthening the impact on the solid powder, accelerating its dissolution, and effectively improving the mixing efficiency.

[0004] However, in the prior art, the above-mentioned biopharmaceutical liquid mixing device directly adds the powder into the mixing cylinder through the feed port when mixing the liquid. This can easily lead to uneven distribution of the powder raw materials in the mixing cylinder, affecting the mixing efficiency. In addition, when there are lumps in the powder raw materials, the lumps directly added to the liquid are difficult to disperse quickly, and may form local concentrations during the mixing process, affecting the uniformity of the mixing. Summary of the Invention

[0005] The present invention provides a liquid medicine mixing device for a filling machine, aiming to solve the problems of uneven addition of powder raw materials and the possibility of directly adding agglomerated powder into the liquid medicine, which affects mixing efficiency and mixing uniformity, existing in the liquid medicine mixing device for biopharmaceuticals in the related art.

[0006] The present invention provides a liquid medicine mixing device for a perfusion machine adopts the following technical solutions: A liquid medicine mixing device for a filling machine comprises a frame and a tank body arranged on the frame, and also comprises a liquid adding pipe located at the center of the tank body and penetrating downward into the tank body, a powder adding pipe offset to one side of the tank body, a rotary drive mechanism for driving the liquid adding pipe to rotate around an axis extending up and down, and a feeding mechanism located in the tank body; the feeding mechanism comprises a cover plate assembly, a sieve plate assembly, and a driving assembly, the cover plate assembly is fixed to the tank body and is provided with a powder inlet corresponding to the powder adding pipe, the liquid adding pipe passes through the cover plate assembly; the sieve plate assembly comprises a sieve plate distributed in space below the cover plate assembly and sleeved on the outside of the liquid adding pipe, the sieve plate has a supporting surface corresponding to the powder inlet, and the cover plate assembly has a supporting surface corresponding to the supporting surface The parallel and opposite extrusion surfaces, the sieve plate and the liquid adding tube are assembled together in a circumferentially fixed manner and in a vertically sliding manner; the driving assembly includes an elastic component, a first block, and a second block. The elastic component is connected to the sieve plate to apply an upward elastic force to the sieve plate. The first block is arranged at the top of the sieve plate assembly, and the second block is arranged at the bottom of the cover plate assembly; when the first block rotates with the sieve plate assembly to the second block, it is pushed downward by the second block to move the sieve plate assembly downward; after the first block rotates with the sieve plate assembly and passes over the second block, the elastic component pulls the sieve plate assembly upward, so that the extrusion surface of the cover plate assembly cooperates with the sieve plate to squeeze out the lumps in the medicinal powder raw materials on the supporting surface.

[0007] By adopting the above technical solution, a feeding mechanism is provided in the tank body. When adding materials, the medicinal powder raw materials are put into the sieve plate in the tank body through the powder adding pipe, and the sieve plate is driven to rotate by the liquid adding pipe, so that the medicinal powder raw materials are evenly distributed along the circumference of the sieve plate. At the same time, the sieve plate assembly is driven by the driving assembly to move up and down while rotating, so that the sieve plate and the cover plate assembly can squeeze and crush the agglomerated parts in the medicinal powder raw materials on the sieve plate, and through the up and down vibration of the sieve plate, the powdered medicinal powder raw materials can pass through the sieve holes on the sieve plate and be evenly sprinkled into the mixed liquid medicine in the tank body; thus, by setting up the feeding mechanism, a uniform feeding method that can break up the raw material agglomerates is realized, which helps the medicinal powder raw materials to be better dispersed in the mixed liquid medicine, which is beneficial to improving production efficiency and mixing uniformity.

[0008] Furthermore, the elastic component includes a connecting ring rotatably mounted at the center of the sieve plate, and a spring connected between the cover plate assembly and the connecting ring. The connecting ring and the sieve plate are relatively fixedly assembled together in the up and down directions.

[0009] Furthermore, the center position of the cover plate assembly has a mounting cavity extending up and down and corresponding to the upper and lower parts of the connecting ring, and the spring is located in the mounting cavity.

[0010] Furthermore, the first stop block is in a semi-cylindrical shape, the second stop block is in an arc-shaped plate shape, and the end surfaces of both ends of the second stop block in the length direction are curved surfaces.

[0011] Furthermore, there is a first annular gap between the outer peripheral side of the sieve plate and the inner wall of the tank body, and the sieve plate assembly also includes a rotating ring located above the first annular gap and a material-shifting piece connected between the sieve plate and the rotating ring; the cover plate assembly includes a cover plate, a fixed ring, and a connecting piece connected between the cover plate and the fixed ring, and there is a second annular gap between the outer peripheral side of the cover plate and the inner wall of the tank body that is adapted to the rotating ring, and the fixed ring is located above the second annular gap.

[0012] By adopting the above technical solution, the rotating ring can enter the second annular gap and seal the second annular gap. At this time, the rotating ring cooperates with the cover plate, which is beneficial to reducing the splashing of the powder raw material.

[0013] Furthermore, the liquid adding tube is assembled on the tank body for movement up and down, and the liquid-medicine mixing device of the filling machine also includes a stirring mechanism located in the tank body and arranged at the lower end of the liquid adding tube, and the stirring mechanism includes a main stirring member and a scraper ring, and the main stirring member is fixed to the lower end of the liquid adding tube, and the outer peripheral side of the main stirring member is connected to the scraper ring and drives the scraper ring to move up and down, and the outer peripheral side of the scraper ring is in contact with the inner wall of the tank body to scrape the agglomerated medicine attached to the inner wall of the tank body to the upper surface of the scraper ring when the scraper ring moves up, and the scraper ring can move up to the first annular gap so that the material-pickup sheet guides the agglomerated medicine on the upper surface of the scraper ring to move to the sieve plate.

[0014] Furthermore, the stirring mechanism further includes auxiliary stirring members, and a plurality of the auxiliary stirring members are arranged on the lower surface of the scraper ring, and the auxiliary stirring members are flush with the lower surface of the main stirring member.

[0015] The above technical solution enables the auxiliary stirring element to cooperate with the main stirring element to cover all areas in the tank body, avoiding the occurrence of mixing dead corners that may cause high or low concentrations in local areas of the tank body, affecting the uniformity of the mixture, and ensuring the mixing effect.

[0016] Furthermore, the stirring mechanism also includes gears and a gear ring, the main stirring member includes a main stirring shaft fixed to the lower end of the liquid adding tube, and a plurality of main stirring blades fixed on the main stirring shaft, each of the main stirring blades has an inclination angle to the inner bottom surface of the tank body, the outer ends of the plurality of main stirring blades are respectively fixed to the inner circumference of the gear ring, and the gear ring is rotatably installed on the scraper ring, the auxiliary stirring member includes an auxiliary stirring shaft, and a plurality of auxiliary stirring blades fixed on the auxiliary stirring shaft, each of the auxiliary stirring blades is perpendicular to the bottom surface of the tank body, and the upper end of the auxiliary stirring shaft extends into the scraper ring and is equipped with a gear meshing with the gear ring.

[0017] The above technical solution is adopted, and the main stirring blade is set as an inclined blade paddle. Under the push of the main stirring blade, the mixed liquid in the tank body not only moves along the axial direction of the main stirring shaft, but also diffuses to the four sides of the tank body, which can provide higher stirring efficiency and accelerate the mixing speed of the liquid medicine and the powder raw materials; the auxiliary stirring blade is set as a straight blade paddle. Under the push of the auxiliary stirring blade, the mixed liquid medicine around the tank body can flow into the tank body, which is beneficial to improve the fluidity at the inner wall of the tank body and optimize the mixing effect; thereby, the coverage area, setting number and shape of the stirring blade are optimized to achieve the best stirring effect and ensure that the liquid medicine and the powder raw materials can be fully mixed.

[0018] Furthermore, the liquid adding pipe is provided with a liquid spraying port above the main stirring member, and a plurality of the liquid spraying ports are evenly arranged along the circumference of the liquid adding pipe. The liquid adding pipe can be moved upward until the liquid spraying port is located between the sieve plate and the cover plate.

[0019] By adopting the above technical solution, the liquid spray port is set above the main stirring piece, which is conducive to the liquid medicine flowing out of the liquid spray port to contact the main stirring piece as soon as possible, and to be mixed with other raw materials in the tank body under the stirring action of the main stirring piece, thereby improving the mixing efficiency; when the liquid adding pipe moves up to the liquid spray port and is located between the sieve plate and the cover plate, the liquid medicine sprayed from the liquid spray port can also flush the small amount of powdered raw materials remaining on the sieve plate, thereby improving the accuracy of the liquid medicine mixing and improving the quality of the medicine.

[0020] Furthermore, the liquid medicine mixing device of the perfusion machine further comprises a linear drive component mounted on the frame, and an output end of the linear drive component is connected to the liquid adding tube to drive the liquid adding tube to move up and down.

[0021] The beneficial effects of the liquid medicine mixing device of a filling machine provided by the present invention are as follows: a feeding mechanism and a stirring mechanism are arranged in the tank body; when adding materials, the powder raw materials are put into the sieve plate in the tank body through the powder adding tube, and the sieve plate is driven to rotate by the liquid adding tube, so that the powder raw materials are evenly distributed along the circumference of the sieve plate, and at the same time, the sieve plate assembly is driven by the driving assembly to move up and down while rotating, so that the sieve plate and the cover plate assembly can squeeze and crush the agglomerated parts of the powder raw materials on the sieve plate, and the up and down vibration of the sieve plate allows the powdered powder raw materials to pass through the sieve holes on the sieve plate and be evenly sprinkled into the mixed liquid medicine in the tank body; thus, by arranging the feeding mechanism, a feeding method that is uniform and can break up the agglomerates of the raw materials is achieved, which helps the powder raw materials to be mixed. The raw materials are better dispersed in the mixed liquid, which is beneficial to improving production efficiency and mixing uniformity; after mixing for a period of time, the main stirring member and the scraper ring are driven to move upward through the liquid adding tube, so that the scraper ring scrapes the agglomerated medicine attached to the inner wall of the tank body to the upper surface of the scraper ring, and controls the scraper ring to move up to the first annular gap. At this time, the material-dispensing piece can guide the agglomerated medicine on the upper surface of the scraper ring to move to the sieve plate, so that the sieve plate can be moved up and down to break it and sprinkle it. Therefore, by setting up a stirring mechanism, the scraping of the medicine attached to the inner wall of the tank body is realized, and the scraped agglomerated medicine is broken in conjunction with the feeding mechanism, so that the scraped agglomerated medicine can be fully and effectively mixed in the tank body, thereby ensuring the consistency of the efficacy of the mixed liquid and improving product quality. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 It is a first structural schematic diagram of the liquid medicine mixing device of the perfusion machine of the present invention.

[0023] Figure 2 This is a second structural schematic diagram of the liquid medicine mixing device of the perfusion machine of the present invention.

[0024] Figure 3 It is a structural schematic diagram of the feeding mechanism and the stirring mechanism of the liquid medicine mixing device of the filling machine of the present invention.

[0025] Figure 4 It is a structural schematic diagram of the cover plate assembly of the liquid medicine mixing device of the filling machine of the present invention.

[0026] Figure 5 It is a structural schematic diagram of the sieve plate assembly of the liquid medicine mixing device of the perfusion machine of the present invention.

[0027] Reference numerals: 10. Tank body; 100. Frame; 110. Powder adding pipe; 120. Filling head; 20. Liquid adding pipe; 210. Liquid spray port; 220. Motor; 230. Linear drive component; 30. Fixed ring; 310. Second stop block; 320. Connecting component; 40. Cover plate; 410. Powder inlet; 420. Mounting cavity; 50. Rotating ring; 510. First stop block; 520. Material shifting piece; 60. Sieve plate; 610. Connecting ring; 620. Spring; 70. Main stirring member; 710. Main stirring shaft; 720. Main stirring blade; 80. Scraper ring; 810. Gear ring; 820. Gear; 90. Auxiliary stirring member; 910. Auxiliary stirring shaft; 920. Auxiliary stirring blade. DETAILED DESCRIPTION

[0028] The embodiments of the present invention are described in detail below, and examples of the embodiments are shown in the accompanying drawings. The embodiments described below with reference to the accompanying drawings are exemplary and intended to be used to explain the present invention, but should not be understood as limiting the present invention.

[0029] The following combination Figures 1 to 5 The present invention describes a liquid medicine mixing device for a perfusion machine.

[0030] like Figures 1 to 5 As shown, an embodiment of the liquid-drug mixing device for a filling machine of the present invention comprises a frame 100, a tank body 10, a filling head 120, a liquid adding pipe 20, a powder adding pipe 110, a rotary drive mechanism, a linear drive member 230, a feeding mechanism, and a stirring mechanism. The tank body 10, the rotary drive mechanism, and the linear drive member 230 are respectively mounted on the frame 100; the liquid adding pipe 20 and the powder adding pipe 110 are respectively mounted on the tank body 10 and extend downwardly into the tank body 10; the filling head 120 is mounted at the bottom of the tank body 10 and is provided with a filling valve; and the feeding mechanism and the stirring mechanism are respectively mounted within the tank body 10.

[0031] like Figures 1 to 3As shown, the liquid adding pipe 20 is located at the center of the tank body 10 and is assembled on the tank body 10 so as to move up and down. The upper end of the liquid adding pipe 20 is connected to the outside world, and the lower part of the liquid adding pipe 20 is provided with a liquid spraying port 210 which penetrates downward into the tank body 10. A plurality of liquid spraying ports 210 are evenly arranged along the circumference of the liquid adding pipe 20 for injecting liquid medicine into the tank body 10. The rotary drive mechanism includes a motor 220, a driving wheel, a transmission belt, and a driven wheel. The output end of the motor 220 is connected to the driving wheel to drive the driving wheel to rotate. The driven wheel and the liquid adding pipe 20 are assembled so as to be relatively fixed in the circumferential direction and relatively slidable in the vertical direction. The driving wheel and the driven wheel are connected by a transmission belt. When the motor 220 drives the driving wheel to rotate, the driving wheel drives the driven wheel to rotate through the transmission belt, and the driven wheel drives the liquid adding pipe 20 to rotate around an axis extending vertically. The output end of the linear actuator 230 is connected to the liquid adding tube 20 to drive the liquid adding tube 20 up and down. The linear actuator 230 is a hydraulic cylinder. In other embodiments, the linear actuator 230 can also be a pneumatic cylinder or an electric push rod. The powder adding tube 110 is fixed offset to one side of the tank body 10. The upper end of the powder adding tube 110 is connected to the outside world, and the lower end of the powder adding tube 110 downwardly penetrates the tank body 10 for adding the powder raw material into the tank body 10.

[0032] like Figures 2 to 5 As shown, the feeding mechanism includes a cover plate assembly, a sieve plate assembly and a driving assembly for driving the sieve plate assembly to move up and down, which are arranged in sequence. The liquid adding pipe 20 passes through the cover plate assembly.

[0033] The cover plate assembly includes a fixing ring 30, a cover plate 40, and a connector 320 connected between the fixing ring 30 and the cover plate 40. The outer peripheral side of the fixing ring 30 is fixed to the inner wall of the tank body 10, and the cover plate 40 is distributed below the fixing ring 30 in the air. The cover plate 40 is provided with a powder inlet 410 corresponding to the powder adding tube 110. The lower surface of the cover plate 40 forms a horizontally distributed extrusion surface, and the center position of the cover plate 40 forms a mounting cavity 420 extending up and down. There is a second annular gap between the outer peripheral side of the cover plate 40 and the inner wall of the tank body 10. The fixing ring 30 is distributed just above the second annular gap. The inner peripheral side of the fixing ring 30 is fixedly connected to the outer peripheral side of the cover plate 40 by the connector 320 to fix the cover plate 40 in the tank body 10.

[0034] The sieve plate assembly includes a rotating ring 50, a sieve plate 60, and a material-selecting piece 520 connected between the rotating ring 50 and the sieve plate 60. The sieve plate 60 is distributed in the air below the cover plate 40 and is sleeved on the outside of the liquid-adding tube 20. The sieve plate 60 and the liquid-adding tube 20 are assembled together so as to be relatively fixed in the circumferential direction and relatively slidable in the vertical direction. The upper surface of the sieve plate 60 forms a horizontally distributed supporting surface opposite to the extrusion surface. The center of the sieve plate 60 in the embodiment is provided with a perforation for installing the liquid-adding tube 20. The side wall of the perforation is provided with a vertical groove connected to the liquid-adding tube 20 for vertical sliding. A first annular gap is provided between the outer peripheral side of the sieve plate 60 and the inner wall of the tank body 10. The rotating ring 50 is distributed directly above the first annular gap and can enter the second annular gap to seal the second annular gap. At this time, the rotating ring 50 cooperates with the cover plate 40 to help reduce the splashing of the powder raw material. A plurality of stripper tabs 520 are fixed to the lower surface of the rotating ring 50 and are fixedly connected to the outer periphery of the sieve plate 60 via these tabs 520. As the rotating ring 50 rotates, the stripper tabs 520 push the medicinal powder material on the upper surface of the scraper ring 80 toward the sieve plate 60. In this embodiment, the stripper tabs 520 are curved, which reduces friction and resistance during the movement of the medicinal powder material, thereby improving flow efficiency. The lower surface of the stripper tabs 520 is flush with the upper surface of the sieve plate 60.

[0035] The driving assembly includes an elastic component, a first stop block 510 , and a second stop block 310 .

[0036] The elastic component includes a connecting ring 610 rotatably mounted at the center of the sieve plate 60, and a spring 620 connected between the cover plate assembly and the connecting ring 610. The cross-section of the connecting ring 610 is narrow at the top and wide at the bottom. The sieve plate 60 has an annular groove for mounting the connecting ring 610, so as to achieve rotational connection and synchronous up and down movement of the connecting ring 610 and the sieve plate 60. The spring 620 is located in the mounting cavity 420, the upper end of the spring 620 is fixed to the cover plate 40, and the lower end of the spring 620 is fixed to the connecting ring 610. The spring 620 is used to apply an upward elastic force to the sieve plate 60 to move the sieve plate 60 upward and closer to the cover plate 40, so that the sieve plate 60 and the cover plate 40 cooperate to squeeze and crush the powder material on the sieve plate 60, and crush the agglomerated parts of the powder material on the sieve plate 60 to prevent them from forming a blockage on the sieve plate 60 or falling into the interior of the tank body 10 and affecting the mixing effect. Furthermore, in other embodiments, the elastic component may only include the spring 620 , and the spring 620 is connected between the liquid adding pipe 20 and the screen plate 60 .

[0037] A plurality of second stops 310 are fixed to the lower surface of the fixed ring 30 along the circumference of the fixed ring 30. Each second stop 310 is in the shape of an arc plate, and the end faces of the second stops 310 at both ends in the length direction are curved surfaces. A plurality of first stops 510 are fixed to the upper surface of the rotating ring 50 along the circumference of the rotating ring 50. Each first stop 510 is in the shape of a semi-cylinder. When the first stop 510 rotates with the sieve plate assembly to the second stop 310, it is pushed downward by the second stop 310 to move the sieve plate assembly downward, and the elastic force of the spring 620 is used to make the sieve plate 60 vibrate up and down, thereby sieving the powdered raw materials on the sieve plate 60, so that the powdered drugs pass through the sieve holes on the sieve plate 60 and are evenly sprinkled into the mixed liquid medicine in the tank body 10, while the sieved agglomerated drugs remain on the sieve plate 60. The parallel and opposite extrusion surfaces and support surfaces can sieve the drugs that fail to pass through the sieve plate 60. The lumps in the sieve holes are broken. Since the distance between the extrusion surface and the supporting surface is the same at any two points, it can ensure that the pressure applied by the extrusion surface and the supporting surface on the agglomerated powder is uniform, which is beneficial to improving the crushing efficiency, thereby preventing the agglomerated powder from falling directly into the medicine liquid and affecting the mixing efficiency and mixing uniformity. At the same time, it also avoids the problem that the agglomerated powder may clog the sieve holes and affect the feeding efficiency of the sieve plate 60, requiring manual disassembly, cleaning and unblocking of the sieve plate 60, thereby realizing a uniform feeding method that can break up the agglomerates of the raw materials, helping the powder raw materials to be better dispersed in the mixed medicine liquid, and helping to improve production efficiency and mixing uniformity.

[0038] like Figure 2 、 Figure 3 and Figure 5 As shown, the stirring mechanism includes a main stirring member 70 , a scraper ring 80 , a gear ring 810 , a gear 820 and an auxiliary stirring member 90 .

[0039] The main stirring member 70 is fixed to the lower end of the liquid adding tube 20 so as to rotate and move up and down with the liquid adding tube 20. The liquid spraying port 210 is located above the main stirring member 70, which is conducive to allowing the liquid medicine flowing out of the liquid spraying port 210 to contact the main stirring member 70 as soon as possible and complete mixing with other raw materials in the tank body 10 under the stirring action of the main stirring member 70, thereby improving mixing efficiency. The main stirring member 70 includes a main stirring shaft 710 and four main stirring blades 720. The main stirring shaft 710 is fixed to the lower end of the liquid adding tube 20, and the four main stirring blades 720 are fixed to the outer peripheral side of the main stirring shaft 710. Each main stirring blade 720 has a certain inclination angle with the bottom surface of the tank body 10. Under the push of the main stirring blades 720, the mixed liquid medicine in the tank body 10 not only moves along the axial direction of the main stirring shaft 710, but also spreads to the surrounding of the tank body 10, thereby providing higher stirring efficiency and accelerating the mixing speed of the liquid medicine and the powder raw materials. The outer ends of the four main stirring blades 720 are respectively fixed to the inner circumference of the gear ring 810, and the gear ring 810 is rotatably installed on the scraper ring 80 so that the main stirring blades 720 can drive the gear ring 810 to rotate when the liquid adding tube 20 rotates, and can drive the scraper ring 80 to move up and down when the main stirring blades 720 move up and down with the liquid adding tube 20.

[0040] A plurality of auxiliary stirring members 90 are arranged on the lower surface of the scraper ring 80, and the auxiliary stirring members 90 are flush with the lower surface of the main stirring member 70. Thus, the auxiliary stirring members 90 can cooperate with the main stirring member 70 to cover all areas inside the tank body 10, avoiding the occurrence of mixing dead corners that cause higher or lower concentrations in local areas of the tank body 10, affecting the uniformity of the mixture, and ensuring the mixing effect.

[0041] Each auxiliary stirring member 90 includes an auxiliary stirring shaft 910 and four auxiliary stirring blades 920. The upper end of the auxiliary stirring shaft 910 extends into the scraper ring 80 and is equipped with a gear 820 that meshes with the gear ring 810. The scraper ring 80 has a cavity for mounting the gear 820. The four auxiliary stirring blades 920 are fixed to the outer peripheral side of the auxiliary stirring shaft 910 and are located below the scraper ring 80, so that when the gear ring 810 rotates, it can drive the auxiliary stirring shaft 910 and the auxiliary stirring blades 920 to rotate by meshing with the gear 820. Each auxiliary stirring blade 920 is perpendicular to the bottom surface of the tank body 10. Under the push of the auxiliary stirring blades 920, the mixed liquid around the tank body 10 can flow into the tank body 10, which is conducive to improving the fluidity at the inner wall of the tank body 10 and optimizing the mixing effect.

[0042] The outer peripheral side of the scraper ring 80 fits with the inner wall of the tank body 10 so that the agglomerated medicine attached to the inner wall of the tank body 10 can be scraped to the upper surface of the scraper ring 80 when the scraper ring 80 moves upward. The scraper ring 80 can move upward to abut against the lower surface of the stripping piece 520. At this time, the scraper ring 80 is located in the first annular gap, and the upper surface of the scraper ring 80 is flush with the upper surface of the sieve plate 60. The stripping piece 520 rotates around the central axis of the tank body 10 driven by the sieve plate 60 to push and guide the agglomerated medicine on the upper surface of the scraper ring 80 to move to the sieve plate 60, and then the sieve plate 60 vibrates up and down to break it and sprinkle it, so that the scraped agglomerated medicine can be fully and effectively mixed in the tank body 10, ensuring the consistency of the efficacy of the mixed medicine liquid and improving product quality.

[0043] The working process of the embodiment of the liquid medicine mixing device for a perfusion machine of the present invention includes the following steps: The first step is to add liquid and powder. The linear drive component 230 and the motor 220 are started. The linear drive component 230 controls the liquid adding tube 20 to move down to the bottom end of the tank body 10. According to the formula requirements of the medicine, the medicine liquid is introduced into the liquid adding tube 20, and the medicine liquid enters the tank body 10 through the liquid spray port 210. The medicine powder raw material is introduced into the powder adding tube 110, and the medicine powder raw material enters the tank body 10 through the lower end of the powder adding tube 110. The motor 220 drives the liquid adding tube 20 to rotate.

[0044] In the second step, the liquid adding pipe 20 drives the sieve plate 60 to rotate around the axis of the liquid adding pipe 20, so that the powder raw materials falling on the sieve plate 60 through the powder inlet 410 are evenly distributed along the circumference of the sieve plate 60; the sieve plate 60 drives the rotating ring 50 and the first stop block 510 and the material shifting piece 520 located on the rotating ring 50 to rotate around the axis of the liquid adding pipe 20, and the spring 620 exerts an upward elastic force on the sieve plate 60 to move the sieve plate 60 up close to the cover plate 40, and the second stop block 310 It can push against the first block 510 to cooperate with the elastic force of the spring 620 to make the sieve plate 60 vibrate up and down, and perform a sieving operation on the powdered raw materials on the supporting surface of the sieve plate 60. The powdered medicine can pass through the sieve holes on the sieve plate 60 and be evenly sprinkled into the mixed liquid medicine in the tank body 10. The sieved agglomerated medicine remains on the sieve plate 60, is squeezed and crushed into powder by the sieve plate 60 and the cover plate 40, and then falls into the mixed liquid medicine in the tank body 10 through the sieve holes on the sieve plate 60.

[0045] In the third step, at the initial stage of mixing, the liquid adding tube 20 drives the main stirring member 70 to rotate around the axis of the liquid adding tube 20, and the main stirring member 70 drives the auxiliary stirring member 90 to rotate through the engagement of the gear 820 with the gear ring 810, thereby stirring and mixing the liquid and powder raw materials.

[0046] The fourth step is the late stage of mixing. After a period of mixing, the linear drive member 230 controls the liquid adding tube 20 to move upward, and the liquid adding tube 20 moves upward to drive the scraper ring 80 to move upward. The scraper ring 80 scrapes the agglomerated medicine attached to the inner wall of the tank body 10 to the upper surface of the scraper ring 80 until the upper surface of the scraper ring 80 is against the lower surface of the material stripping piece 520. At this time, the scraper ring 80 is located in the first annular gap, and the upper surface of the scraper ring 80 is flush with the upper surface of the sieve plate 60. The rotating stripper 520 pushes and guides the agglomerated medicine on the upper surface of the scraper ring 80 to move onto the sieve plate 60, and then the agglomerated medicine is broken and scattered through the up and down vibration of the sieve plate 60; at the same time, the liquid spray port 210 of the liquid adding pipe 20 moves between the sieve plate 60 and the cover plate 40, and the remaining liquid medicine is introduced into the liquid adding pipe 20. The liquid medicine is sprayed onto the sieve plate 60 through the liquid spray port 210 to rinse the small amount of powdered medicine remaining on the sieve plate 60.

[0047] The fifth step is filling and sealing. The filling valve on the filling head 120 is opened, the mixed liquid medicine is filled into the container through the filling head 120, and the container is sealed and packaged.

[0048] In this way, the liquid medicine mixing device of the filling machine is provided with a feeding mechanism and a stirring mechanism in the tank body 10; when adding materials, the powder raw materials are put into the sieve plate 60 in the tank body 10 through the powder adding pipe 110, and the sieve plate 60 is driven to rotate by the liquid adding pipe 20, so that the powder raw materials are evenly distributed along the circumference of the sieve plate 60, and at the same time, the elastic force of the spring 620 and the push of the first block 510 and the second block 310 are used to make the sieve plate 60 vibrate up and down. When the sieve plate 60 vibrates upward, it can cooperate with the cover plate 40 to crush the agglomerated parts of the powder raw materials on the sieve plate 60, and through the up and down vibration of the sieve plate 60, the powdered powder raw materials pass through the sieve holes on the sieve plate 60 and are evenly sprinkled in the mixed liquid medicine in the tank body 10; thus, by setting up the feeding mechanism, a uniform feeding method that can break up the agglomerates of the raw materials is realized. , helping the powder raw materials to be better dispersed in the mixed medicine liquid, which is beneficial to improving production efficiency and mixing uniformity; after mixing for a period of time, the main stirring member 70 and the scraper ring 80 are driven to move upward through the liquid adding pipe 20, so that the scraper ring 80 scrapes the agglomerated medicine attached to the inner wall of the tank body 10 to the upper surface of the scraper ring 80, and controls the scraper ring 80 to move up to the first annular gap. At this time, the material-prying piece 520 can guide the agglomerated medicine on the upper surface of the scraper ring 80 to move to the sieve plate 60, so as to crush and sprinkle it through the up and down vibration of the sieve plate 60; thus, by setting up the stirring mechanism, the scraping of the medicine attached to the inner wall of the tank body 10 is realized, and the scraped agglomerated medicine is crushed in conjunction with the feeding mechanism, so that the scraped agglomerated medicine can be fully and effectively mixed in the tank body 10, ensuring the consistency of the efficacy in the mixed medicine liquid and improving product quality.

[0049] In other embodiments of the liquid-drug mixing device for a perfusion machine of the present invention, the stirring mechanism at the bottom can be removed, and only stirring blades can be provided on the liquid-adding tube 20. In this case, the liquid-adding tube 20 can rotate but cannot move up and down. In this case, the sieve plate assembly and the cover plate assembly can be flat plates located at the same level.

[0050] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise", "axial", "radial", "circumferential" and the like to indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as limiting the present invention.

[0051] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be understood to indicate or imply relative importance or implicitly specify the number of technical features being referred to. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In the description of the present invention, "plurality" means at least two, such as two or three, unless otherwise specifically defined.

[0052] Although the embodiments of the present invention have been shown and described above, it will be understood that the above embodiments are illustrative and are not to be construed as limitations on the present invention. A person skilled in the art may change, modify, replace and modify the above embodiments within the scope of the present invention.

Claims

1. A liquid medicine mixing device for a filling machine, comprising a frame (100) and a tank body (10) arranged on the frame (100), It is characterized in that It also includes a liquid adding pipe (20) located at the center of the tank body (10) and penetrating downward into the tank body (10), a powder adding pipe (110) offset to one side of the tank body (10), a rotary drive mechanism for driving the liquid adding pipe (20) to rotate around an axis extending vertically, and a feeding mechanism located in the tank body (10); The feeding mechanism comprises a cover plate assembly, a screen plate assembly, and a driving assembly. The cover plate assembly is fixed in a tank body (10) and is provided with a powder inlet (410) corresponding to a powder adding tube (110). The liquid adding tube (20) passes through the cover plate assembly. The screen plate assembly comprises a screen plate (60) which is spaced and distributed below the cover plate assembly and sleeved on the outside of the liquid adding tube (20). The screen plate (60) has a supporting surface corresponding to the powder inlet (410). The cover plate assembly has an extrusion surface which is parallel to the supporting surface. The screen plate (60) and the liquid adding tube (20) are assembled together so as to be relatively fixed in the circumferential direction and relatively slidable in the vertical direction. The driving assembly comprises an elastic component, a first stop block (5 10) A second stopper (310), an elastic component connected to the sieve plate (60) to apply an upward elastic force to the sieve plate (60), the first stopper (510) being arranged at the top of the sieve plate assembly, and the second stopper (310) being arranged at the bottom of the cover plate assembly; when the first stopper (510) rotates with the sieve plate assembly to the second stopper (310), the first stopper (310) is pushed downward by the second stopper (310) to move the sieve plate assembly downward; after the first stopper (510) rotates with the sieve plate assembly and passes over the second stopper (310), the elastic component pulls the sieve plate assembly upward, so that the extrusion surface of the cover plate assembly cooperates with the sieve plate to squeeze out the lumps in the medicine powder raw material on the supporting surface.

2. A liquid medicine mixing device for a perfusion machine according to claim 1, It is characterized in that The elastic component comprises a connecting ring (610) rotatably mounted at the center of the sieve plate (60), and a spring (620) connected between the cover plate assembly and the connecting ring (610); the connecting ring (610) and the sieve plate (60) are relatively fixedly assembled together in the up and down directions.

3. A liquid medicine mixing device for a perfusion machine according to claim 2, It is characterized in that The center position of the cover plate assembly has a mounting cavity (420) extending up and down and corresponding to the connecting ring (610) up and down, and the spring (620) is located in the mounting cavity (420).

4. A liquid medicine mixing device for a perfusion machine according to claim 1, It is characterized in that The first stop block (510) is in the shape of a semi-cylinder, the second stop block (310) is in the shape of an arc plate, and the end surfaces of both ends of the second stop block (310) in the length direction are curved surfaces.

5. A liquid medicine mixing device for a perfusion machine according to any one of claims 1 to 4, It is characterized in that A first annular gap is formed between the outer peripheral side of the sieve plate (60) and the inner wall of the tank body (10), and the sieve plate assembly further comprises a rotating ring (50) located above the first annular gap and a material shifting piece (520) connected between the sieve plate (60) and the rotating ring (50); The cover plate assembly comprises a cover plate (40), a fixing ring (30), and a connecting piece (320) connected between the cover plate (40) and the fixing ring (30); a second annular gap matching the rotating ring (50) is provided between the outer peripheral side of the cover plate (40) and the inner wall of the tank body (10); and the fixing ring (30) is located above the second annular gap.

6. A liquid medicine mixing device for a perfusion machine according to claim 5, It is characterized in that The liquid adding tube (20) is assembled on the tank body (10) so as to move up and down. The liquid medicine mixing device of the filling machine further comprises a stirring mechanism located in the tank body (10) and arranged at the lower end of the liquid adding tube (20). The stirring mechanism comprises a main stirring member (70) and a scraping ring (80). The main stirring member (70) is fixed to the lower end of the liquid adding tube (20). The outer peripheral side of the main stirring member (70) is connected to the scraping ring (80) and drives the scraping ring (80) to move up and down. The outer peripheral side of the scraping ring (80) is in contact with the inner wall of the tank body (10) so as to scrape the agglomerated medicine attached to the inner wall of the tank body (10) onto the upper surface of the scraping ring (80) when the scraping ring (80) moves up. The scraping ring (80) can move up to the first annular gap so that the material shifting piece (520) guides the agglomerated medicine on the upper surface of the scraping ring (80) to move onto the sieve plate (60).

7. A liquid medicine mixing device for a perfusion machine according to claim 6, It is characterized in that The stirring mechanism further comprises auxiliary stirring members (90), a plurality of the auxiliary stirring members (90) being arranged on the lower surface of the scraper ring (80), and the auxiliary stirring members (90) being flush with the lower surface of the main stirring member (70).

8. A liquid medicine mixing device for a perfusion machine according to claim 7, It is characterized in that The stirring mechanism further comprises a gear (820) and a gear ring (810); the main stirring member (70) comprises a main stirring shaft (710) fixed to the lower end of the liquid adding tube (20) and a plurality of main stirring blades (720) fixed to the main stirring shaft (710); each of the main stirring blades (720) has an inclined angle with the inner bottom surface of the tank body (10); the outer ends of the plurality of main stirring blades (720) are respectively fixed to the inner circumference of the gear ring (810); the gear ring (810) is rotatably mounted on the scraper ring (80); the auxiliary stirring member (90) comprises an auxiliary stirring shaft (910) and a plurality of auxiliary stirring blades (920) fixed to the auxiliary stirring shaft (910); each of the auxiliary stirring blades (920) is perpendicular to the bottom surface of the tank body (10); the upper end of the auxiliary stirring shaft (910) extends into the scraper ring (80) and is equipped with a gear (820) meshing with the gear ring (810).

9. A liquid medicine mixing device for a perfusion machine according to claim 6, It is characterized in that The liquid adding pipe (20) is provided with a liquid spraying port (210) above the main stirring member (70), and a plurality of the liquid spraying ports (210) are evenly arranged along the circumference of the liquid adding pipe (20). The liquid adding pipe (20) can be moved upward until the liquid spraying port (210) is located between the sieve plate (60) and the cover plate (40).

10. The liquid medicine mixing device for a perfusion machine according to claim 1, It is characterized in that The liquid medicine mixing device for the perfusion machine further comprises a linear drive member (230) mounted on the frame (100), wherein an output end of the linear drive member (230) is connected to the liquid adding tube (20) to drive the liquid adding tube (20) to move up and down.

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