Anti-caries gel and application thereof in caries prevention

Abstract

The invention relates to an anti-caries gel and an application thereof in caries prevention. The anti-caries gel comprises sodium fluoride, calcium glycerophosphate, allantoin, sodium pyrophosphate, silicon dioxide, hydroxyapatite, a humectant, a thickener, an antibacterial agent and distilled water. Sodium fluoride is used as a fluorine source and is combined with hydroxyapatite in tooth enamel to reduce the solubility of the enamel, the hydroxyapatite is used for promoting tooth remineralization, calcium glycerophosphate is used for decalcifying teeth and adsorbing calcium and phosphorus, micropores are filled to achieve the purpose of promoting tooth remineralization, and finally the effect of preventing decayed teeth and tooth ache is achieved. And a thin protective film is formed on the surface of teeth after use, so that the teeth are protected and remineralized. Meanwhile, the oral cavity is continuously fresh and comfortable. The anti-caries gel is used in cooperation with a denture, the gel can completely wrap teeth, and the anti-caries gel is easier, faster and more effective to use and is not limited to use scenes.

Description

Technical Field

[0001] The present invention relates to the technical field of oral care, and in particular to an anti-caries gel and an application thereof in the anti-caries process. Background Art

[0002] Dental caries is a disease in which the hard tissue of the teeth is gradually destroyed. It is a common and frequently occurring disease in children. If dental caries is not treated in time, in addition to causing pain in the affected teeth and difficulty in chewing, further development may lead to the loss of the affected teeth, affecting the digestive ability of children, and sometimes secondary pulpitis and apical periodontitis, and even inflammation of the alveolar bone and jawbone; secondary infection of dental caries can form lesions, leading to or aggravating systemic diseases such as myocarditis, arthritis, rheumatic fever, nephritis, etc., which will cause varying degrees of damage to children's body and mind. According to statistics from the Chinese Center for Disease Control and Prevention, the prevalence of dental caries in children aged 3 to 5 years old exceeds 70%, and the prevalence of dental caries in children under 5 years old is increasing year by year. This shows that the problem of dental caries in young children is still a serious public health challenge. The occurrence of dental caries in young children will not only affect the physical and oral health of children, but also have an adverse impact on their life and study. In fact, the cause of dental caries is tooth decalcification. Decalcification refers to the appearance of countless micropores on the surface of the tooth as calcium and phosphorus fall off the surface of the enamel, causing the enamel to gradually become thinner and weaker. After decalcification, it is easy to breed caries and induce symptoms such as toothache.

[0003] Compared with gel products, the existing anti-caries products, such as fluoride toothpaste, fluoride application at dental clinics, fluoride mouthwash and other products, cannot solve the problem of children being able to apply fluoride at home, and are simple to operate and long-term effective in preventing caries. The gel is in a flowing state, and when used, it can wrap the teeth well, including the gaps between teeth that are not easy to reach. It is simple to operate and can better achieve the purpose of fluoride application, which brings convenience to people who need to protect their teeth, brings a better experience to young people, and helps young people to adhere to fluoride application and protect their teeth. The existing known gel technologies all use fluoride sources and hydroxyapatite as the main components to prevent caries and promote tooth remineralization. However, the calcium and phosphorus wrapped on the surface of the teeth can only be adsorbed on a layer of the enamel surface, which is difficult to fill into the micropores, which greatly reduces the purpose of mineralization. Summary of the invention

[0004] In view of the above problems, the present invention proposes an anti-caries gel, which can promote decalcified teeth to absorb calcium and phosphorus, promote tooth remineralization by filling micropores, thereby achieving the desired purpose, and can be used in conjunction with a dental tray, and is easy to operate.

[0005] To achieve the above purpose, the following technical scheme is adopted: an anti-caries gel, characterized in that the weight proportions of the components of the gel are 1-2 parts of sodium fluoride, 0.05-0.12 parts of calcium glycerophosphate, 0.2-0.35 parts of allantoin, 0.05-0.15 parts of sodium pyrophosphate, 0.5-1.5 parts of silicon dioxide, 1-1.5 parts of hydroxyapatite, 25-40 parts of moisturizing agent, 0.1-7 parts of thickener, 0.01-0.05 parts of antibacterial agent, and the rest is distilled water.

[0006] Preferably, the components of the gel also include 0.1-1 part of a flavor regulator and 0.01-0.2 part of a sweetener.

[0007] The present invention also provides the application of the above-mentioned caries prevention gel in caries prevention. The caries prevention gel is contained in a dental tray with a tooth template and used in conjunction with a tooth occlusal dental tray, so that the gel wraps the entire mouth of teeth.

[0008] Beneficial effects of the present invention: The present invention can promote the adsorption of calcium and phosphorus by decalcified teeth, and achieve the purpose of promoting the remineralization of teeth by filling micropores, and finally achieve the effect of preventing caries and tooth pain, and form a thin protective film on the surface of the teeth to protect the remineralization of teeth. At the same time, the oral cavity is kept fresh and comfortable. The anti-caries gel of the present invention is used in conjunction with a dental tray, and the gel can completely wrap the teeth, which is simpler, faster, and more effective to use, and is not limited to the use scenario. DETAILED DESCRIPTION

[0009] As analyzed in the background technology of the present invention, the gel has fluoride source and hydroxyapatite as main components. Calcium and phosphorus on the surface of teeth can only be adsorbed on the surface of enamel and are difficult to fill into the micropores of enamel. Therefore, the present application proposes an anti-caries gel in an implementation manner. The weight proportions of the components of the gel are 1-2 parts of sodium fluoride, 0.05-0.12 parts of calcium glycerophosphate, 0.2-0.35 parts of allantoin, 0.05-0.15 parts of sodium pyrophosphate, 0.5-1.5 parts of silicon dioxide, 1-1.5 parts of hydroxyapatite, 25-40 parts of moisturizer, 0.1-7 parts of thickener, 0.01-0.05 parts of antibacterial agent, 0.1-1 parts of flavor regulator, 0.01-0.2 parts of sweetener, and the rest is distilled water.

[0010] Sodium fluoride is used as the fluoride source, which combines with hydroxyapatite in the enamel to reduce the solubility of the enamel. Hydroxyapatite can promote tooth remineralization. Calcium glycerophosphate can induce calcium-phosphorus adsorption. Allantoin can prevent periodontal disease, that is, prevent gum disease. Sodium pyrophosphate can prevent tar deposits; silicon dioxide can remove plaque.

[0011] The technical solution of the present invention is further described below in conjunction with embodiments.

[0012] Examples 1-3 and Comparative Example 1

[0013] The weight percentages of the components of the anti-caries gel in each embodiment are shown in Table 1;

[0014]

[0015]

[0016] Table 1

[0017] Examples 1-3 and Comparative Example 1 were placed in containers respectively, and the containers were shaken. The gels in the containers all flowed slowly, among which the gel in Example 2 was relatively viscous and flowed extremely slowly.

[0018] The caries-proof gels of Examples 1-3 and Comparative Example 1 were used as test samples and directly contacted with the cheek pouch mucosa of golden hamsters to evaluate the irritation of the test samples to the oral mucosa of hamsters. The four test samples were placed in the cheek pouches of four hamsters, respectively, with the test samples placed in the right cheek pouch of each hamster and the control samples placed in the left cheek pouch. The test samples were in full contact with the mucosa at the bottom of the cheek pouch, and the test samples were removed after 10 minutes of contact. After 24 hours, the mucosal tissue of the sample contact site was evaluated visually and histologically. Under the conditions of this experiment, the four test sample caries-proof gels had no irritating effect on the oral mucosa of golden hamsters.

[0019] Examples 1-3 and comparative example 1 were placed in dental trays of tooth templates, respectively. Four adults bit the four dental trays respectively so that the gel of the test samples was completely wrapped around the teeth. After biting for 0.5 minutes, the dental trays were taken out, and a layer of gel protective film was clearly seen on the tooth surfaces of the four adults.

[0020] The samples were subjected to remineralization test.

[0021] Bovine teeth with the same conditions were taken and immersed in an acetic acid buffer solution (75 mmol / L, pH adjusted to 4.0) for 72 h to form artificial caries samples.

[0022] The test samples of Examples 1-3 and Comparative Example 1 were used to remineralize bovine teeth respectively. The bovine teeth corresponding to Example 1 were marked as T1, the bovine teeth corresponding to Example 2 were marked as T2, the bovine teeth corresponding to Example 3 were marked as T3, and the bovine teeth corresponding to Comparative Example 1 were marked as D1. The experimental conditions were that the test samples were applied to the surface of the bovine teeth for 8 hours each time and stored in simulated saliva. After 7 days, the effects of the bovine teeth were observed under a scanning electron microscope and measured under an energy dispersive X-ray spectrum. The results are shown in Table 2.

[0023]

[0024] Table 2

[0025] When the calcium-phosphorus ratio is greater than 1.67, it indicates that a hydroxyapatite mineralized layer is formed. Table 2 shows that the fluoride ions and hydroxyapatite contained in the gel have a significant effect on tooth remineralization. Since the gel in Comparative Example 1 does not contain calcium glycerophosphate to induce calcium-phosphorus adsorption, the filling effect on the micropores of the enamel is poor, and the ideal remineralization effect is not achieved.

[0026] When the present invention is used, the dental tray with a tooth template is filled with the anti-caries gel and used in conjunction with the tooth occlusal dental tray, so that the gel wraps the entire mouth of teeth, which is the most ideal effect.

[0027] Although the embodiments of the present invention have been shown and described above, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. An anti-caries gel, characterized in that: The weight proportions of the components of the gel are 1-2 parts of sodium fluoride, 0.05-0.12 parts of calcium glycerophosphate, 0.2-0.35 parts of allantoin, 0.05-0.15 parts of sodium pyrophosphate, 0.5-1.5 parts of silicon dioxide, 1-1.5 parts of hydroxyapatite, 25-40 parts of moisturizing agent, 0.1-7 parts of thickening agent, 0.01-0.05 parts of antibacterial agent, and the rest is distilled water.

2. The anti-caries gel according to claim 1, characterized in that The components of the gel also include 0.1-1 part of a flavor regulator and 0.01-0.2 part of a sweetener.

3. Use of the anti-caries gel according to claim 2 in anti-caries, characterized in that: The anti-caries gel is contained in a dental tray with a tooth template and used in conjunction with a tooth occlusal dental tray, so that the gel wraps the entire mouth of teeth.

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