Fixing device for medical test animal

Abstract

The invention relates to a fixing device for medical experiment animals, and belongs to the technical field of medical experiment instruments. In order to solve the problems that an existing restraining device for experimental animals is low in automation degree and causes compression during restraining, an operation table is arranged, a body restraining mechanism, four-limb restraining mechanisms and a buffering mechanism are arranged on the operation table, and the body restraining mechanism is arranged in the middle of the operation table and movably connected with the operation table; the four-limb restraining mechanisms are symmetrically arranged at the two ends of the body restraining mechanism in the length direction of the body restraining mechanism, and the buffering mechanism is located on the operation table and connected with the body restraining mechanism. The design of the elastic bandages and the binding belts is adopted, meanwhile, the buffering effect of the air bag cushion is matched, excessive compression or injury generated when the body and the four limbs of the experimental animal are restrained is effectively reduced, automatic operation is achieved through the driver, the driver is used for driving the adjusting plate to move downwards, and the operation is convenient. The body and the four limbs of the test animal can be restrained synchronously, and the restraining efficiency of the test animal is effectively improved.

Description

Technical Field

[0001] The invention relates to the technical field of medical experimental instruments, in particular to a fixing device for medical experimental animals. Background Art

[0002] In medical experiments, experimental animals are often used. Accurate and rapid fixation of experimental animals is one of the key factors for the success of the experiment. However, most traditional fixation methods rely on manual operation, which has the risk of operational errors and consumes a lot of time and energy. Existing tools for fixing experimental animals mostly use a tube body and an end cap to restrain the experimental animal in the tube body. Since the diameter of the tube body cannot be adjusted, this type of restraint tool cannot clamp the experimental animal radially, which can easily cause the experimental animal to be injured due to local squeezing.

[0003] At present, some other devices for fixing experimental animals have also appeared, such as the Chinese patent with patent number CN113974893B and the name of a restraint device for mouse experiments, which includes an end cover, a tube body and a slider, the end cover and the tube body are slidably connected, the end cover can open or close the tube body port after sliding relative to the tube body, and the slider is slidably connected to the tube body in the direction close to or away from the end cover. In this prior art, the radial size of the tube body can be adjusted, and the multi-directional clamping of the mouse makes the restraint more stable, avoiding excessive squeezing and injury of the mouse locally; another example is the Chinese patent with patent number CN114097629B and the name of a fixing device for medical experimental animals, which includes a base, a limited cavity is arranged on the base, an opening for mice to enter is opened at the top of the limited cavity, limited assemblies are arranged on the two side walls of the limited cavity, and a feeding assembly is also arranged on the front end surface of the limited cavity, etc. This prior art can better unify the specific activity state of experimental mice, facilitate the unification of experimental comparison, and can feed the mice at a fixed time, which is convenient to operate.

[0004] However, the above-mentioned prior art still has the following inconveniences in the application of fixation of experimental animals: first, the degree of automation of the fixation process of mice is low, and most of it relies on manual operation, which is time-consuming and labor-intensive; second, the fixation process of mice will cause varying degrees of oppression, which is contrary to animal ethics and welfare principles; third, the above-mentioned fixation device cannot spread the limbs of the mouse, which is not convenient for experimental operations. Summary of the invention

[0005] In view of the defects existing in the above-mentioned prior art, the present invention aims to provide a fixation device for medical experimental animals, through the innovative design of the cylinder and the clever linkage of the sliding plates that restrain the limbs of the experimental animals, the cylinder is used to drive the adjustment plate to move downward, so that the bandage is tightened while pulling the sliding plate to slide outward, thereby simultaneously achieving the body restraint and limb restraint of the experimental animal, and realizing the stable restraint and natural deployment of the experimental animal. In this process, the gas discharged from the cylinder is used to inflate the airbag cushion to avoid excessive compression during restraint, thereby solving some problems existing in the background technology.

[0006] In order to achieve the above object, the present invention adopts the following technical solutions: In one aspect, the present invention discloses a fixing device for medical experimental animals, comprising an operating table, on which are arranged: The body restraint mechanism is arranged in the middle of the operating table and is movably connected to the operating table; The limb restraint mechanism is arranged on the operating table and distributed along the front-to-back direction of the body restraint mechanism. The test animal is fixed by cooperating with the body restraint mechanism through the limb restraint mechanism.

[0007] As a further preferred embodiment of the above technical solution: the body restraint mechanism includes a driver, an adjustment plate and a plurality of bandages, the driver and the adjustment plate are both arranged below the operating table, the adjustment plate is fixedly connected to the driver, and the plurality of bandages respectively penetrate the operating table and are distributed along the length direction of the adjustment plate.

[0008] Based on the above technical solution, further, a plurality of fixing columns are arranged at the bottom of the adjustment plate, and each fixing column is connected to the limb restraint mechanism.

[0009] As a further preferred embodiment of the above technical solution: the limb restraint mechanism includes four restraint components symmetrically distributed at both ends of the bandage, each restraint component cooperates with the slide on the operating table, and the limbs of the test animal are restrained accordingly through the restraint components.

[0010] Based on the above technical solution, further, the constraint assembly includes a fixing part and an adjusting part, the fixing part is detachably connected to the slide, the adjusting part is movably connected to the slide, the adjusting part is connected to the fixed column through a first pull rope, and the rope body of the first pull rope bypasses the fixing part.

[0011] A further preferred solution is that the fixing part includes a mounting plate and a guide plate, the mounting plate is clamped on the slideway, the guide plate is fixedly connected to the mounting plate, and the first pull rope is connected to the fixing column after passing around the guide plate.

[0012] Based on the above technical solution, further, the adjustment part is also connected to the limit block at the bottom of the operating table through a second pull rope.

[0013] A further preferred solution is that the adjustment part includes a sliding plate and a restraining belt, the sliding plate is located above the guide plate and cooperates with the slideway, the restraining belt is connected to the top of the sliding plate, and the restraining belt and the limit block are respectively connected to the two ends of the second pull rope.

[0014] A further preferred solution is that the device is also provided with a buffer mechanism, which is located on the operating table and connected to the body restraint mechanism. The buffer mechanism includes an airbag cushion and an air duct. The airbag cushion is arranged on the top of the operating table, and the two ends of the air duct are respectively connected to the airbag cushion and the driver.

[0015] In another embodiment, the present invention also discloses a method for using a fixation device for medical experimental animals, comprising the following steps: Step 1: Adjust the limb restraint mechanism to the corresponding slide slot according to the type of test animal; Step 2: Place the test animal on the operating table, with the body of the test animal lying on the airbag cushion, and the four limbs of the test animal stretched toward its head and tail respectively; Step 3: Turn on the driver, and the driver drives the adjustment plate to move downward. During the downward movement of the adjustment plate, the bandage moves downward synchronously to restrain the body of the test animal. At this time, the first pull rope is pulled by the downward movement of the fixed column, and the first pull rope pulls the sliding plate to move through its other end. During the movement of the sliding plate to the side away from the limit block, under the cooperation and restriction of the limit block and the second pull rope, the second pull rope tightens the restraint belt to restrain the limbs of the test animal. At the same time, the gas in the driver enters the airbag cushion through the airway tube to buffer the body of the test animal. Step 4: After the restraint is completed, the experimental animals are subjected to the next experimental operation.

[0016] Compared with the prior art, the present invention has the following beneficial effects: 1. The device of the present invention adopts an elastic bandage and restraint belt design, which effectively reduces excessive pressure or injury on the body and limbs of the test animal when restrained, improves the comfort of the test animal in the restrained state, and through the design of three sets of slides in different positions and replaceable limb restraint mechanisms, it can flexibly adapt to test animals of different sizes and types, ensure the stability and safety of the test animals when restrained, and has strong adaptability.

[0017] 2. The device of the present invention realizes automatic operation by setting a driver (cylinder). The body and limbs of the test animal can be restrained synchronously only by the driver driving the adjustment plate to move downward, thereby effectively improving the restraint efficiency of the test animal and reducing the risks that may be caused by manual operation errors.

[0018] 3. The body restraint mechanism, limb restraint mechanism and buffer mechanism provided in the present invention are an integral linkage mechanism. While restraining the body of the test animal, the downward movement of the adjustment plate is used to pull the first pull rope, so that the other end of the first pull rope pulls the sliding plate to move along the slide groove. During the movement of the sliding plate, due to the limiting effect of the limit block and the second pull rope, the second pull rope will pull the restraint belt to shrink toward the inside of the sliding plate, thereby achieving the purpose of tightening the limbs of the test animal, and cleverly integrates the air cavity compression mechanism. While tightening the body of the test animal, gas is filled into the airbag cushion, which effectively buffers the body of the test animal, thereby ensuring the comfort of the test animal and effectively preventing excessive compression. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art are briefly introduced below.

[0020] Figure 1 It is a schematic diagram of the overall structure of the fixing device for medical experimental animals of the present invention; Figure 2 It is a structural schematic diagram of the overall structure of the present invention from another angle; Figure 3 It is a structural schematic diagram of the overall structure of the present invention from another angle; Figure 4 A top view of the overall structure of the present invention; Figure 5 An internal perspective view of the connection between the bandage and the adjustment plate of the present invention; Figure 6 A diagram showing the coordination relationship between the body restraint mechanism and the limb restraint mechanism of the present invention; Figure 7 It is an enlarged view of the details of the coordination between the body restraint mechanism and the limb restraint mechanism of the present invention; Figure 8 It is an enlarged structural diagram of the limb restraint mechanism of the present invention; Fig. 9 is a cross-sectional view of the adjustment portion of the present invention; Fig.10 is an internal perspective view of the adjustment portion of the present invention; In the figure: 1. operating table; 11. rectangular table top; 12. supporting legs; 13. slideway; 14. limiting block; 2. body restraint mechanism; 21. driver; 22. adjustment plate; 23. bandage; 24. fixing column; 3. limb restraint mechanism; 31. fixing part; 311. mounting plate; 312. guide plate; 32. adjustment part; 321. sliding plate; 322. restraint belt; 33. first pull rope; 34. second pull rope; 4. buffer mechanism; 41. airbag cushion; 42. air duct. DETAILED DESCRIPTION

[0021] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments.

[0022] In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "front", "rear", "vertical", "horizontal", "inner", "outer", etc., indicating the orientation or positional relationship, are based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operate in a specific orientation, and therefore cannot be understood as limiting the present invention. In addition, the terms "first", "second", etc., are only used for descriptive purposes and cannot be understood as indicating or implying relative importance.

[0023] Embodiment 1: Reference Figure 1-5 The present invention provides a fixing device for medical experimental animals, including an operating table 1, the operating table 1 includes a rectangular table top 11 and four legs 12 supported at the bottom of the rectangular table top 11, the center of the rectangular table top 11 is the restraint area of ​​the experimental animal, and a body restraint mechanism 2 and a limb restraint mechanism 3 are arranged on the operating table 1, the body restraint mechanism 2 is arranged in the middle of the operating table 1, and the body restraint mechanism 2 is movably connected to the operating table 1, and the limb restraint mechanism 3 is arranged on the operating table 1 and distributed along the front and back directions of the body restraint mechanism 2, and the test animal is fixed by the limb restraint mechanism 3 cooperating with the body restraint mechanism 2; the experimental animals in the present invention mainly refer to limb animals used for medical experiments, such as mice (rats, mice, guinea pigs, etc.), rabbits, etc. In order to adapt to different types of experimental animals, three groups of slides 13 in different directions are correspondingly opened on the rectangular table top 11, and according to the type of experimental animals, slides 13 in different positions are used to cooperate with the limb restraint mechanism 3, so as to restrain different types of experimental animals.

[0024] Specifically, the body restraint mechanism 2 includes a driver 21, an adjustment plate 22 and a plurality of bandages 23, such as Figure 3-5As shown, the driver 21 and the adjustment plate 22 are both arranged below the operating table 1, the adjustment plate 22 is fixedly connected to the driver 21, and a plurality of bandages 23 are distributed along the length direction of the adjustment plate 22, and each bandage 23 passes through the operating table 1 and is connected to the adjustment plate 22; in this embodiment, the bandage 23 has moderate elasticity and is provided with three bandages in total. The design length of each bandage 23 is different according to the different body parts of the restrained test animal, and the tightness of each bandage 23 is appropriate after restraining the body of the test animal; the driver 21 in this embodiment adopts a cylinder, and in order to increase the stability of the cylinder, a limit bracket is provided at the bottom of the cylinder so that the cylinder is located in the limit bracket.

[0025] like Figure 3 As shown, a plurality of fixing columns 24 are provided at the bottom of the adjusting plate 22, and the plurality of fixing columns 24 are respectively distributed at the bottom of the adjusting plate 22 along the length direction. In the present embodiment, there are four fixing columns 24 in total, and two fixing columns 24 are respectively connected to the two ends of the adjusting plate 22, and each fixing column 24 is correspondingly connected to the limb restraint mechanism 3; when it is necessary to restrain the test animal, the driver 21 is started, and the adjusting plate 22 is driven downward by the driver 21, and the bandage 23 moves downward during the downward movement of the adjusting plate 22, so as to restrain and fix the body of the test animal.

[0026] Embodiment 2: In order to better unfold and restrain the limbs of the test animal while fixing the body of the test animal, the limb restraint mechanism 3 is further improved and optimized based on Example 1.

[0027] like Figure 6-10 As shown, the limb restraint mechanism 3 includes restraint components symmetrically distributed at both ends of the bandage. According to the type of test animal that needs to be fixed, the restraint component is matched with the slide 13 at the corresponding position on the operating table 1. It can be understood that the slide 13 away from the rectangular table 11 is used in combination with the restraint component to restrain the limbs of larger test animals, the slide 13 close to the rectangular table 11 is used in combination with the restraint component to restrain the limbs of smaller test animals, and the slide 13 located in the middle is used in combination with the restraint component to restrain the limbs of medium-sized test animals.

[0028] Specifically, the constraint assembly includes a fixing part 31 and an adjusting part 32. The fixing part 31 is detachably connected to the slide 13. The adjusting part 32 is movably connected to the slide 13. A first pull rope 33 is connected between the adjusting part 32 and the fixed column 24. The first pull rope 33 is wound around the fixing part 31. A limit block 14 is provided at the bottom of the operating table 1 near each slide 13. A second pull rope 34 is connected between the adjusting part 32 and the limit block 14.

[0029] Furthermore, if Figure 6As shown, the fixing portion 31 includes a mounting plate 311 and a guide plate 312. The mounting plate 311 is a rectangular structure. A protrusion is fixedly connected to one side of the mounting plate 311. The protrusion is matched with a groove on the side wall of the slide slot 13. The mounting plate 311 is detachably clamped to the slideway 13 by matching the protrusion with the groove. The guide plate 312 is a special-shaped structure, and the guide plate 312 is fixedly connected to the side of the mounting plate 311 opposite to the protrusion. One end of the first pull rope 33 is fixedly connected to the adjustment portion 32, and the other end thereof passes through the guide plate 312 and then passes through the fixing column 24 to realize a detachable connection. One end of the first pull rope 33 connected to the fixing column 24 is a free end. When cooperating with the slideway 13 at different positions, the free end of the first pull rope 33 is adjusted to make its length appropriate, and then the free end of the first pull rope 33 is knotted and fixed.

[0030] like Figure 7-10 As shown, the adjustment portion 32 includes a sliding plate 321 and a restraining belt 322. The sliding plate 321 is located above the guide plate 312. The sliding plate 321 is a T-shaped structure. The vertical plate of the sliding plate 321 matches the width of the slide groove 13. The horizontal plate of the sliding plate 321 is located at the top of the slide groove 13, so that the sliding plate 321 can slide in the limiting area of ​​the slideway 13. Fig.10 As shown, a cavity and a rope hole are opened inside the sliding plate 321, the rope hole is connected to the cavity, the restraining belt 322 is connected to the top of the sliding plate 321 (that is, the horizontal plate of the sliding plate 321), and the two ends of the second pull rope 34 are respectively connected to the restraining belt 322 and the limit block 14, wherein: one end of the restraining belt 34 is fixedly connected to the sliding plate 321, and the other end of the restraining belt 322 is a movable end, and its movable end is passed through the fine groove on the sliding plate 321 in the cavity, and the movable end of the restraining belt 322 is connected to one end of the second pull rope 34 passed through the rope hole, and the other end of the second pull rope 34 is detachably connected to the limit block 14.

[0031] During the process of fixing the body of the test animal, as the adjustment plate 22 moves downward, the fixed column 24 connected to the adjustment plate 22 moves downward synchronously. When the fixed column 24 moves downward, it drives the free end of the first pull rope 33 to move downward. At this time, the first pull rope 33 pulls the sliding plate 321 under the action of the guide plate 312, and the sliding plate 321 moves along the direction of the slide groove 13. During the movement of the sliding plate 321, due to the limiting effect of the limit block 14, one end of the second pull rope 34 connected to the restraint belt 322 begins to tighten. Therefore, during the process of restraining the body of the test animal, the limbs are tightened and restrained synchronously.

[0032] Embodiment 3: Based on the above embodiments 1-2, in order to prevent the test animal from being injured due to excessive squeezing during the restraint of the body and limbs of the test animal, the present invention further provides a buffer mechanism 4, and the specific structure of the buffer mechanism 4 is as follows: like Figure 2 , Figure 4 , Figure 6 As shown, the buffer mechanism 4 includes an airbag cushion 41 and an air duct 42. The airbag cushion 41 is laid at the top center of the rectangular table 11. The laying position of the airbag cushion 41 corresponds to the body position of the test animal. One end of the air duct 42 is connected to the exhaust hole of the driver 21, and the other end of the air duct 42 passes through the operating table 11 and is connected to the airbag cushion 41.

[0033] During the body restraint process of the test animal, the driver 21 is turned on to drive the adjustment plate 22 to move downward. At this time, the inner cavity of the driver 21 compresses the air downward. After the air is discharged through the exhaust hole, it enters the airbag cushion 41 through the air guide tube 42 to inflate the airbag cushion 41. The test animal is placed on the airbag cushion 41 to avoid excessive pressure.

[0034] Embodiment 4: The fixing device for medical experimental animals of the present invention, when used in practical applications: First, the test personnel install the limb restraint mechanism 3 at the corresponding position of the slide slot 13 according to the type of test animal to be fixed, and connect the two ends of the air guide tube 42 to the driver 21 and the airbag cushion 41 respectively; Next, the test personnel places the test animal on the operating table 1, so that the test animal lies prone on the airbag cushion 41, and then stretches the four limbs of the test animal toward its head and tail respectively, so that the four limbs are located at the corresponding restraint belts 322; Next, the driver 21 is turned on and the top of the driver 21 is moved downward, and the driver 21 drives the adjustment plate 22 to move downward. At this time, the fixed column 24 moves downward synchronously, so that the bandage 23 connected to the fixed column 24 moves downward synchronously to restrain the body of the test animal. In the process of the fixed column 24 moving downward, the free end of the first pull rope 33 connected to the fixed column 24 moves downward, and the other end of the first pull rope 33 therefore pulls the sliding plate 321 to move along the slide groove 13, and because one end of the second pull rope 34 is connected to the limit block 14 and is restricted When the sliding plate 321 moves away from the limit block 14, under the cooperation and restriction of the limit block 14 and the second pull rope 34, the other end of the second pull rope 34 tightens the restraint belt 322 toward the inside of the sliding plate 321, so as to restrain the limbs of the test animal. In this process, since the inner cavity of the driver 21 compresses the air downward, this part of the air is discharged and enters the airbag cushion 41 through the air guide tube 42, so that the airbag cushion 41 plays a buffering role on the body of the test animal after being inflated, so as to avoid excessive pressure on the test animal during the fixing process; Finally, after the body and limbs of the experimental animals are restrained, subsequent experimental operations are carried out.

[0035] The above shows and describes the basic principles, main features and advantages of the present invention. It should be understood by those skilled in the art that the present invention is not limited to the above embodiments, and the above embodiments and descriptions are only for explaining the principles of the present invention. Without departing from the spirit and scope of the present invention, the present invention may have various changes and improvements, which fall within the scope of the present invention to be protected. The scope of protection of the present invention is defined by the attached claims and their equivalents.

Claims

1. A fixing device for medical experimental animals, comprising an operating table (1), characterized in that: The operating table (1) is provided with: A body restraint mechanism (2) is arranged in the middle of the operating table (1) and is movably connected to the operating table (1); The limb restraint mechanism (3) is arranged on the operating table (1) and distributed along the front-to-back direction of the body restraint mechanism (2). The test animal is fixed by cooperating with the body restraint mechanism (2) through the limb restraint mechanism (3).

2. The fixing device for medical experimental animals according to claim 1, characterized in that: The body restraint mechanism (2) comprises a driver (21), an adjustment plate (22) and a plurality of bandages (23); the driver (21) and the adjustment plate (22) are both arranged below the operating table (1); the adjustment plate (22) is fixedly connected to the driver (21); and the plurality of bandages (23) respectively penetrate the operating table (2) and are distributed along the length direction of the adjustment plate (22).

3. The fixing device for medical experimental animals according to claim 2, characterized in that: A plurality of fixing columns (24) are arranged at the bottom of the adjustment plate (22), and each fixing column (24) is connected to the limb restraint mechanism (3).

4. The fixing device for medical experimental animals according to claim 3, characterized in that: The limb restraint mechanism (3) comprises four restraint components, each of which cooperates with a slideway (13) on the operating table (1), and the limbs of the test animal are restrained accordingly through the restraint components.

5. The fixing device for medical experimental animals according to claim 4, characterized in that: The restraint assembly comprises a fixing portion (31) and an adjusting portion (32), wherein the fixing portion (31) is detachably connected to the slideway (13), the adjusting portion (32) is movably connected to the slideway (13), the adjusting portion (32) is connected to the fixing column (24) via a first pull rope (33), and the rope body of the first pull rope (33) passes around the fixing portion (31).

6. The fixing device for medical experimental animals according to claim 5, characterized in that: The fixing portion (31) comprises a mounting plate (311) and a guide plate (312); the mounting plate (311) is clamped on the slideway (13); the guide plate (312) is fixedly connected to the mounting plate (311); and the first pull rope (33) is connected to the fixing column (24) after passing around the guide plate (312).

7. The fixing device for medical experimental animals according to claim 6, characterized in that: The adjustment portion (32) is also connected to a limit block (14) at the bottom of the operating table (1) via a second pull rope (34).

8. The fixing device for medical experimental animals according to claim 7, characterized in that: The adjustment portion (32) comprises a sliding plate (321) and a restraining belt (322); the sliding plate (321) is located above the guide plate (312) and movably cooperates with the slideway (13); the restraining belt (322) is connected to the top of the sliding plate (321); and the restraining belt (322) and the limiting block (14) are respectively connected to two ends of the second pull rope (34).

9. The fixing device for medical experimental animals according to claim 2, characterized in that: A buffer mechanism (4) is also provided. The buffer mechanism (4) is located on the operating table (1) and is connected to the body restraint mechanism (2). The buffer mechanism (4) comprises an airbag cushion (41) and an air guide tube (42). The airbag cushion (41) is provided on the top of the operating table (1), and two ends of the air guide tube (42) are respectively connected to the airbag cushion (41) and the driver (21).

10. The method for using the fixation device for medical experimental animals according to any one of claims 1 to 9, characterized in that: The following steps are involved: Step 1: According to the type of the test animal, adjust the limb restraint mechanism (3) to the corresponding slide groove (13); Step 2: Place the test animal on the operating table (1), with the body of the test animal lying on the airbag cushion (41), and the four limbs of the test animal extending toward the head and tail respectively; Step 3: Turn on the driver (21), and the driver (21) drives the adjustment plate (22) to move downward. During the downward movement of the adjustment plate (22), the bandage (23) simultaneously moves downward to restrain the body of the test animal. At this time, the first pull rope (33) is pulled by the downward movement of the fixed column (24), and the first pull rope (33) pulls the sliding plate (321) to move through its other end. During the movement of the sliding plate (321) to the side away from the limit block (14), under the cooperation and restriction of the limit block (14) and the second pull rope (34), the second pull rope (34) tightens the restraint belt (322) to restrain the limbs of the test animal. At the same time, the gas in the driver (21) enters the airbag cushion through the air guide tube (42), which has a buffering effect on the body of the test animal. Step 4: After the restraint is completed, the experimental animals are subjected to the next experimental operation.

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