Liquid preparation system based on multifunctional pilot platform and liquid preparation chromatography system thereof

Abstract

The invention provides a liquid preparation system based on a multifunctional pilot platform and a liquid preparation chromatography system thereof. The liquid preparation system comprises a first input main pipeline and a second input main pipeline which are respectively connected with a plurality of input pipelines; the outlet end of each input pipeline is connected with a liquid inlet port of the corresponding movable installation module, and each movable installation module is further provided with a plurality of liquid outlet ports. Each liquid outlet port is connected with a plurality of collecting pipelines through an output pipeline; the first input main pipeline is respectively connected with the two collecting pipelines through valves; the second input main pipeline is respectively connected with the plurality of collecting pipelines through valves; the second input main pipeline is connected with the first input main pipeline through a valve; the first input module is connected with an external pump module through a valve; a plurality of chromatographic columns are mounted in an inner shell of the movable mounting module; the device has the advantages that ternary liquid preparation and quaternary online dilution liquid preparation can be realized through a single pump and double pumps, and online liquid preparation chromatography is realized.

Description

Technical Field

[0001] The present invention relates to a liquid preparation system in the downstream pharmaceutical field, and in particular to a liquid preparation system based on a multifunctional pilot platform and a liquid preparation chromatography system thereof. Background Art

[0002] The online buffer solution preparation system is used to mix the diluent (water for injection) and several single-component concentrated solutions (acid, alkali, salt, etc.) online according to the formula and the required amount to obtain the buffer solution required for the final production. In the prior art, the above solution is usually prepared under the action of a precision plunger pump and a mixer, and then collected, and then transported from the liquid storage tank when needed. Or the solution preparation system is directly connected to the chromatography column to meet the buffer solution required for chromatography. Its disadvantages are: single function, cannot meet the requirements of solution preparation or solution chromatography under different working conditions, its application range is relatively small, and multiple sets of equipment increase the cost. Summary of the invention

[0003] In order to overcome the above-mentioned deficiencies of the prior art, the present invention provides a liquid preparation system based on a multifunctional pilot platform and a liquid preparation chromatography system thereof, which can meet the needs of liquid preparation and liquid preparation chromatography, expand the functions of the system, and meet the production processes under different working conditions.

[0004] In order to achieve the above object, the technical solution adopted by the present invention is:

[0005] In view of the above technical problems, the first aspect of the disclosure of the present invention proposes a liquid distribution system based on a multifunctional automatic pilot platform, the platform system includes a first input main pipeline with a first input pump and a second input main pipeline with a second input pump; the first input main pipeline is connected to multiple input pipelines and is controlled to be on and off by corresponding valves; the second input main pipeline is also respectively connected to the multiple input pipelines and is controlled to be on and off by corresponding valves; the outlet end of each of the input pipelines is respectively connected to the liquid inlet port of the corresponding movable installation module, and the movable installation module is also provided with multiple liquid outlet ports; each of the liquid outlet ports is respectively connected to multiple collecting pipelines through an output pipeline; the first input main pipeline is respectively connected to the two collecting pipelines mentioned above through valves; the second input main pipeline is respectively connected to the multiple collecting pipelines mentioned above through valves; the second input main pipeline is connected to the first input main pipeline through a valve; the first input module is connected to an external pump module through a valve; a mixer is provided on the first input main pipeline; the connecting ends of the second input main pipeline, the external pump module and the first input main pipeline are located on one side of the inlet end of the mixer.

[0006] In some embodiments, two input pipes are provided, and the corresponding movable installation module has two liquid inlet ports, two liquid outlet ports, and two output pipes respectively.

[0007] In some embodiments, the outlet end of the first input main pipeline is connected to the first valve array group, and the first valve array group includes four valves connected end to end to form a rectangular valve array; a group of opposite sides of the rectangular valve array are respectively connected to the outlet end of the first input main pipeline and the outlet of the connecting pipeline; the output end of the connecting pipeline is respectively connected to the multiple collecting pipelines through multiple intermediate pipelines; another group of opposite sides of the rectangular valve array are respectively connected to the inlets of the two input pipelines.

[0008] In some embodiments, the second input main pipeline is connected to the output end of the connecting pipeline through a pipeline, and a valve is provided on the pipeline.

[0009] In some embodiments, the input pipeline and the output pipeline are connected one-to-one through pipelines, and valves are provided on the pipelines.

[0010] In some embodiments, two collecting pipes are provided.

[0011] In some embodiments, the two output pipes are respectively connected to a second valve array group, and the second valve array group includes four valves connected end to end to form a rectangular valve array; one group of opposite sides of the rectangular valve array corresponds to the outlet ends of the output pipes; the other group of opposite sides of the rectangular valve array corresponds to the inlets of the two collecting pipes.

[0012] In some embodiments, the external pump module includes a third input main pipeline, a plurality of input pumps are disposed at the inlet end of the third input main pipeline, and the third input main pipeline is respectively connected to the first input main pipeline.

[0013] In some embodiments, one or two input pumps are provided at the inlet end of the third input main pipeline.

[0014] In some embodiments, the first input main pipeline and / or the second input main pipeline and / or the external pump module are respectively provided with a pressure sensor and / or a flow sensor.

[0015] In some embodiments, the collection pipe is respectively provided with an ultraviolet sensor and / or a first conductivity sensor and / or a pH sensor.

[0016] The first aspect of the present invention discloses a liquid preparation chromatography system based on a multifunctional automatic pilot platform, wherein the platform system comprises a first input main pipeline with a first input pump and a second input main pipeline with a second input pump; the first input main pipeline is connected to a plurality of input pipelines and is controlled on and off by corresponding valves; the second input main pipeline is also respectively connected to the plurality of input pipelines and is controlled on and off by corresponding valves; the outlet end of each of the input pipelines is respectively connected to the liquid inlet port of the corresponding movable installation module, and the movable installation module is also provided with a plurality of liquid outlet ports; each of the liquid outlet ports is respectively connected to a plurality of collection pipelines through an output pipeline; the first input pipeline The main pipeline is connected to the two collecting pipelines mentioned above through valves respectively; the second input main pipeline is connected to the multiple collecting pipelines mentioned above through valves respectively; the second input main pipeline is connected to the first input main pipeline through a valve; the first input module is connected to the external pump module through a valve; a mixer and a bubble trap are arranged on the first input main pipeline; the connecting ends of the second input main pipeline, the external pump module and the first input main pipeline are located on one side of the inlet end of the mixer; multiple chromatography columns are placed in the movable installation module, and the bottom inlet and outlet of each chromatography column are connected to the input pipeline through the corresponding liquid inlet port; the top inlet and outlet of the chromatography column are connected to the output pipeline through the corresponding liquid outlet port.

[0017] In some embodiments, two input pipes are provided, and the corresponding movable installation module has two liquid inlet ports, two liquid outlet ports, and two output pipes respectively, and one or two chromatography columns are used.

[0018] In some embodiments, the outlet end of the first input main pipeline is connected to the first valve array group, and the first valve array group includes four valves connected end to end to form a rectangular valve array; a group of opposite sides of the rectangular valve array are respectively connected to the outlet end of the first input main pipeline and the outlet of the connecting pipeline; the output end of the connecting pipeline is respectively connected to the multiple collecting pipelines through multiple intermediate pipelines; another group of opposite sides of the rectangular valve array are respectively connected to the inlets of the two input pipelines.

[0019] In some embodiments, the second input main pipeline is connected to the output end of the connecting pipeline through a pipeline, and a valve is provided on the pipeline.

[0020] In some embodiments, the input pipeline and the output pipeline are connected one-to-one through pipelines, and valves are provided on the pipelines.

[0021] In some embodiments, two collecting pipes are provided.

[0022] In some embodiments, the two output pipes are respectively connected to a second valve array group, and the second valve array group includes four valves connected end to end to form a rectangular valve array; one group of opposite sides of the rectangular valve array corresponds to the outlet ends of the output pipes; the other group of opposite sides of the rectangular valve array corresponds to the inlets of the two collecting pipes.

[0023] In some embodiments, the external pump module includes a third input main pipeline, a plurality of input pumps are disposed at the inlet end of the third input main pipeline, and the third input main pipeline is respectively connected to the first input main pipeline.

[0024] In some embodiments, one or two input pumps are provided at the inlet end of the third input main pipeline.

[0025] In some embodiments, the first input main pipeline and / or the second input main pipeline and / or the external pump module are respectively provided with a pressure sensor and / or a flow sensor.

[0026] In some embodiments, the collection pipe is respectively provided with an ultraviolet sensor and / or a first conductivity sensor and / or a pH sensor.

[0027] Beneficial effects of the present invention:

[0028] The present invention adds an external pump module on the basis of the multifunctional automatic pilot platform, realizes the liquid preparation function, and expands the application scope. At the same time, single pump and double pump can realize ternary liquid preparation and quaternary online dilution liquid preparation.

[0029] The present invention adds an external pump module and a chromatography column on the basis of a multifunctional automatic pilot platform, thereby realizing online liquid preparation chromatography. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] Figure 1 It is a schematic diagram of the structure of the liquid preparation system of the present invention.

[0031] Figure 2 It is a structural schematic diagram of the liquid chromatography of the present invention. DETAILED DESCRIPTION

[0032] The present invention will be further described below in conjunction with the accompanying drawings.

[0033] The technical content of the present invention is described below by specific embodiments. Those skilled in the art can easily understand other advantages and effects of the present invention from the contents disclosed in this specification. The present invention can also be implemented or applied through other different specific embodiments. Those skilled in the art can make various modifications and changes without departing from the spirit of the present invention.

[0034] Before describing the specific embodiments of the present disclosure in detail, some terms used in the present disclosure are first explained.

[0035] Unless otherwise defined below, the meaning of all technical terms and scientific terms used herein is intended to be the same as those commonly understood by those skilled in the art. Mentioning the technology used in this article is intended to refer to the technology commonly understood in the art, including those changes in technology that are obvious to those skilled in the art or the replacement of equivalent technology. Although it is believed that the following terms are well understood by those skilled in the art, the following definitions are still set forth to better explain the present invention. When a trade name appears in this article, it is intended to refer to the corresponding commodity. All patents, published patent applications and publications cited herein are incorporated herein by reference.

[0036] Unless otherwise indicated herein, multiple references such as "a", "the", include plural references. The expression "one or more" or "at least one" may mean 1, 2, 3, 4, 5, 6, 7, 8, 9 or more.

[0037] As used herein, the terms “connected”, “connected”, “coupled” or “coupled” and the like are not limited to direct connections but also include indirect connections.

[0038] As used herein, a "sample" is a biomolecule, including proteins, nucleic acids, lipids, carbohydrates, small nucleotides, amino acids and their derivatives.

[0039] As used herein, the term "online monitoring" or "real-time monitoring" refers to real-time detection of certain parameters or properties of buffers, reaction fluids, and fluids flowing out of flow reactors during use of the chromatography system, such as pH, pressure, flow rate, conductivity, etc. Unlike offline detection or analysis, online monitoring or real-time monitoring can provide real-time feedback of the detection results.

[0040] As mentioned in this article, the A2 liquid storage tank, A3 liquid storage tank, A4 liquid storage tank, A5 liquid storage tank, P1 liquid storage tank, P1-W liquid storage tank, P2 liquid storage tank, and P2-W liquid storage tank refer to tanks used to store different solutions, not tanks with specific limitations. Any container that can realize the storage function is sufficient.

[0041] The position relationship words "up", "down", "left", "right", "front", "back", etc. involved in this article are determined according to the layout direction of the drawings in the specification. They are only used to indicate relative position relationships. When the absolute position of the object being described changes, the relative position relationship may also change accordingly.

[0042] The application scenarios of this patent are laboratory scale and pilot scale, and the maximum flow range of a single pump is 1000ml / min.

[0043] Reference Figure 1 As shown, the liquid dispensing system based on the multifunctional automatic pilot platform includes a first input main pipeline 5, the input end of which is connected to the A2 liquid storage tank through a first valve 1 and connected to the A1 liquid storage tank through a second valve 12. The first input main pipeline 5 is provided with a first input pump 2, a first pressure sensor 3, a first flow sensor 4, a third valve 6, a mixer 7 and an air trap 8 from left to right.

[0044] The second input main pipeline 19, the input end of the second input main pipeline 19 is connected to the A3 liquid storage tank through the fourth valve 15, connected to the A4 liquid storage tank through the fifth valve 14, and connected to the A5 liquid storage tank through the sixth valve. The second input main pipeline 19 is provided with a second input pump 16, a second pressure sensor 17, and a second flow sensor 18 from left to right. The second input main pipeline 19 is connected to the first input main pipeline 5 through the seventh valve 20, and the connection point is between the third valve 6 and the mixer 7. The A3 liquid storage tank is connected to the inlet end of the first input main pipeline 5 through the thirty-seventh valve 13.

[0045] The external pump module includes a third input main pipeline 30, the input end of which is connected to the A6 liquid storage tank through the eighth valve 25 and to the A7 liquid storage tank through the ninth valve 26. The third input main pipeline 30 is provided with a third input pump 27, a third pressure sensor 28, and a third flow sensor 29 from left to right. The third input main pipeline 30 is connected to the first input main pipeline 5 through the tenth valve 22, and the connection point is between the third valve 6 and the mixer 7.

[0046] The output end of the first input main pipeline 5 is connected to the first valve array group 32. The first valve array group 32 includes four valves connected end to end to form a rectangular valve array, including the eleventh valve 33, the twelfth valve 34, the thirteenth valve 35 and the fourteenth valve 36. The output end of the first input main pipeline 5 is connected between the eleventh valve 33 and the fourteenth valve 36; the inlet end of the first connecting pipe 78 is connected between the twelfth valve 34 and the thirteenth valve 35, and the outlet end of the first connecting pipe 78 is connected to the inlet end of the first intermediate pipeline connection 66 and the second intermediate pipeline 67 through the fifteenth valve 65 and the sixteenth valve 64. The outlet ends of the first intermediate pipeline connection 66 and the second intermediate pipeline 67 are connected to the outlet end of the first collecting pipeline 53 and the outlet end of the second collecting pipeline 54 through the nineteenth valve 60 and the twentieth valve 62 respectively. The second input main pipeline 19 is connected to the outlet end of the first connecting pipe 78 through the second connecting pipe 23, and the seventeenth valve 21 and the eighteenth valve 31 are respectively arranged at both ends of the second connecting pipe 23. The inlet end of the first input pipeline 38 is connected between the eleventh valve 33 and the twelfth valve 34, the outlet end of the first input pipeline 38 is connected to the first liquid inlet port 39 of the movable installation module 40, and the first input pipeline 38 is provided with a twenty-first valve 37. The inlet end of the second input pipeline 42 is connected between the thirteenth valve 35 and the fourteenth valve 36, the outlet end of the second input pipeline 42 is connected to the second liquid inlet port 41 of the movable installation module 40, and the second input pipeline 42 is provided with a twenty-second valve 79. The first liquid outlet port 50 of the movable installation module 40 is connected to the liquid inlet end of the first output pipeline 75, and the second liquid outlet port 44 of the movable installation module 40 is connected to the second output pipeline 43. The first output pipeline 75 is provided with a twenty-third valve 51 and a twenty-fourth valve 52 respectively. The second output pipeline 43 is provided with a twenty-fifth valve 80 and a twenty-sixth valve 49. The first input pipeline 38 is connected to the first output pipeline 75 through the third connecting pipeline 45. One end of the third connecting pipeline 45 is located between the 21st valve 37 and the first valve array 32, and the other end is located between the 23rd valve 51 and the 24th valve 52. The third connecting pipeline 45 is provided with a 27th valve 46. The second input pipeline 42 is connected to the second output pipeline 43 through the fourth connecting pipeline 47. One end of the fourth connecting pipeline 47 is located between the 22nd valve 79 and the first valve array 32, and the other end is located between the 25th valve 80 and the 26th valve 49. The fourth connecting pipeline 47 is provided with a 28th valve 48. The first output pipeline 75 and the second output pipeline 43 are respectively connected to the second valve array group 70. The second valve array group 70 includes four valves connected end to end to form a rectangular valve array, including the 29th valve 71, the 30th valve 72, the 31st valve 73 and the 32nd valve 74.The outlet of the second output pipeline 43 is connected between the 29th valve 71 and the 32nd valve 74, the outlet of the first output pipeline 75 is connected between the 30th valve 72 and the 31st valve 73, the inlet of the first collection pipeline 53 is connected between the 29th valve 71 and the 30th valve 72, and the inlet of the second collection pipeline 54 is connected between the 31st valve 73 and the 32nd valve 74. The first collection pipeline 53 is provided with a first UV sensor 55, a first conductivity sensor 56, and a first pH sensor 57, respectively. The outlet of the first collection pipeline 53 is connected to the P1 liquid storage tank and the P1-W liquid storage tank respectively through the 33rd valve 58 and the 34th valve 59. The second collection pipeline 54 is provided with a second conductivity sensor 68 and a second pH sensor 69, respectively. The outlet of the second collection pipeline 54 is connected to the P2 liquid storage tank and the P2-W liquid storage tank through the 35th valve 61 and the 36th valve 63.

[0047] Reference Figure 2 As shown, the liquid preparation chromatography system based on the multifunctional automatic pilot platform includes a first input main pipeline 5,

[0048] The input end of the first input main pipeline 5 is connected to the A2 liquid storage tank through the first valve 1, and is connected to the A1 liquid storage tank through the second valve 12. The first input main pipeline 5 is provided with a first input pump 2, a first pressure sensor 3, a first flow sensor 4, a third valve 6, a mixer 7 and an air trap 8 from left to right.

[0049] The second input main pipeline 19, the input end of the second input main pipeline 19 is connected to the A3 liquid storage tank through the fourth valve 15, connected to the A4 liquid storage tank through the fifth valve 14, and connected to the A5 liquid storage tank through the sixth valve. The second input main pipeline 19 is provided with a second input pump 16, a second pressure sensor 17, and a second flow sensor 18 from left to right. The second input main pipeline 19 is connected to the first input main pipeline 5 through the seventh valve 20, and the connection point is between the third valve 6 and the mixer 7. The A3 liquid storage tank is connected to the inlet end of the first input main pipeline 5 through the thirty-seventh valve 13.

[0050] The external pump module includes a third input main pipeline 30, the input end of which is connected to the A6 liquid storage tank through the eighth valve 25 and to the A7 liquid storage tank through the ninth valve 26. The third input main pipeline 30 is provided with a third input pump 27, a third pressure sensor 28, and a third flow sensor 29 from left to right. The third input main pipeline 30 is connected to the first input main pipeline 5 through the tenth valve 22, and the connection point is between the third valve 6 and the mixer 7.

[0051] The output end of the first input main pipeline 5 is connected to the first valve array group 32. The first valve array group 32 includes four valves connected end to end to form a rectangular valve array, including the eleventh valve 33, the twelfth valve 34, the thirteenth valve 35 and the fourteenth valve 36. The output end of the first input main pipeline 5 is connected between the eleventh valve 33 and the fourteenth valve 36; the inlet end of the first connecting pipe 78 is connected between the twelfth valve 34 and the thirteenth valve 35, and the outlet end of the first connecting pipe 78 is connected to the inlet end of the first intermediate pipeline connection 66 and the second intermediate pipeline 67 through the fifteenth valve 65 and the sixteenth valve 64. The outlet ends of the first intermediate pipeline connection 66 and the second intermediate pipeline 67 are connected to the outlet end of the first collecting pipeline 53 and the outlet end of the second collecting pipeline 54 through the nineteenth valve 60 and the twentieth valve 62 respectively. The second input main pipeline 19 is connected to the outlet end of the first connecting pipe 78 through the second connecting pipe 23, and the seventeenth valve 21 and the eighteenth valve 31 are respectively arranged at both ends of the second connecting pipe 23. The inlet end of the first input pipeline 38 is connected between the eleventh valve 33 and the twelfth valve 34, and the outlet end of the first input pipeline 38 is connected to the first liquid inlet port 39 of the movable installation module 40, and the twenty-first valve 37 is provided on the first input pipeline 38. The inlet end of the second input pipeline 42 is connected between the thirteenth valve 35 and the fourteenth valve 36, and the outlet end of the second input pipeline 42 is connected to the second liquid inlet port 41 of the movable installation module 40, and the twenty-second valve 79 is provided on the second input pipeline 42. The first liquid inlet port 39 is connected to the bottom inlet and outlet of the first chromatography column 76, and the second liquid inlet port 41 is connected to the bottom inlet and outlet of the second chromatography column 77; the top inlet and outlet of the first chromatography column 76 is connected to the first liquid outlet port 50 of the movable installation module 40. The top inlet and outlet of the second chromatography column 77 is connected to the second liquid outlet port 44 of the movable installation module 40. The first liquid outlet port 50 of the movable installation module 40 is connected to the liquid inlet end of the first output pipeline 75, and the second liquid outlet port 44 of the movable installation module 40 is connected to the second output pipeline 43. The first output pipeline 75 is provided with a twenty-third valve 51 and a twenty-fourth valve 52. The second output pipeline 43 is provided with a twenty-fifth valve 80 and a twenty-sixth valve 49. The first input pipeline 38 and the first output pipeline 75 are connected via a third connecting pipeline 45, one end of the third connecting pipeline 45 is located between the twenty-first valve 37 and the first valve array 32, and the other end is located between the twenty-third valve 51 and the twenty-fourth valve 52. The third connecting pipeline 45 is provided with a twenty-seventh valve 46. The second input pipeline 42 and the second output pipeline 43 are connected via a fourth connecting pipeline 47, one end of the fourth connecting pipeline 47 is located between the twenty-second valve 79 and the first valve array 32, and the other end is located between the twenty-fifth valve 80 and the twenty-sixth valve 49. The fourth connecting pipeline 47 is provided with a twenty-eighth valve 48.The first output pipeline 75 and the second output pipeline 43 are respectively connected to the second valve array group 70. The second valve array group 70 includes four valves connected end to end to form a rectangular valve array, including the 29th valve 71, the 30th valve 72, the 31st valve 73 and the 32nd valve 74. The outlet of the second output pipeline 43 is connected between the 29th valve 71 and the 32nd valve 74, the outlet of the first output pipeline 75 is connected between the 30th valve 72 and the 31st valve 73, the inlet of the first collection pipeline 53 is connected between the 29th valve 71 and the 30th valve 72, and the inlet of the second collection pipeline 54 is connected between the 31st valve 73 and the 32nd valve 74. The first collection pipeline 53 is respectively provided with a first ultraviolet sensor 55, a first conductivity sensor 56 and a first pH sensor 57. The outlet of the first collection pipeline 53 is respectively connected to the P1 liquid storage tank and the P1-W liquid storage tank through the 33rd valve 58 and the 34th valve 59. The second collecting pipe 54 is provided with a second conductivity sensor 68 and a second pH sensor 69 respectively. The outlet end of the second collecting pipe 54 is connected to the P2 liquid storage tank and the P2-W liquid storage tank through the thirty-fifth valve 61 and the thirty-sixth valve 63.

Claims

1. A liquid preparation system based on a multifunctional automatic pilot platform, characterized in that: The platform system includes a first input main pipeline with a first input pump and a second input main pipeline with a second input pump; the first input main pipeline is connected to multiple input pipelines and is controlled to be on and off by corresponding valves; the second input main pipeline is also respectively connected to the above-mentioned multiple input pipelines and is controlled to be on and off by corresponding valves; the outlet end of each of the input pipelines is respectively connected to the liquid inlet port of the corresponding movable installation module, and the movable installation module is also provided with multiple liquid outlet ports; each of the liquid outlet ports is respectively connected to multiple collecting pipelines through an output pipeline; the first input main pipeline is respectively connected to the two collecting pipelines mentioned above through valves; the second input main pipeline is respectively connected to the multiple collecting pipelines mentioned above through valves; the second input main pipeline is connected to the first input main pipeline through a valve; the first input module is connected to an external pump module through a valve; a mixer is provided on the first input main pipeline; the connecting ends of the second input main pipeline, the external pump module and the first input main pipeline are located on one side of the inlet end of the mixer.

2. The liquid preparation system based on the multifunctional automatic pilot platform according to claim 1 is characterized in that: The input pipes are provided with two, and the corresponding movable installation module has two liquid inlet ports, two liquid outlet ports, and two output pipes respectively.

3. The liquid preparation system based on the multifunctional automatic pilot platform according to claim 2 is characterized in that: The outlet end of the first input main pipeline is connected to the first valve array group, and the first valve array group includes four valves connected end to end to form a rectangular valve array; a group of opposite sides of the rectangular valve array are respectively connected to the outlet end of the first input main pipeline and the outlet of the connecting pipeline; the output end of the connecting pipeline is respectively connected to the multiple collecting pipelines through multiple intermediate pipelines; another group of opposite sides of the rectangular valve array are respectively connected to the inlets of the two input pipelines.

4. The liquid preparation system based on the multifunctional automatic pilot platform according to claim 3 is characterized in that: The second input main pipeline is connected to the output end of the connecting pipeline through a pipeline, and a valve is arranged on the pipeline.

5. The liquid preparation system based on the multifunctional automatic pilot platform according to claim 3 is characterized in that: The input pipeline and the output pipeline are connected one by one through pipelines, and valves are arranged on the pipelines.

6. The liquid preparation system based on the multifunctional automatic pilot platform according to claim 3 is characterized in that: There are two collecting pipes.

7. The liquid preparation system based on the multifunctional automatic pilot platform according to claim 3 is characterized in that: The two output pipes are respectively connected to the second valve array group, which includes four valves connected end to end to form a rectangular valve array; one group of opposite sides of the rectangular valve array corresponds to the outlet ends of the output pipes; the other group of opposite sides of the rectangular valve array corresponds to the inlets of the two collecting pipes.

8. The liquid preparation system based on the multifunctional automatic pilot platform according to claim 3 is characterized in that: The external pump module comprises a third input main pipeline, a plurality of input pumps are arranged at the inlet end of the third input main pipeline, and the third input main pipeline is connected to the first input main pipeline respectively.

9. The liquid preparation system based on the multifunctional automatic pilot platform according to claim 8, characterized in that: The inlet end of the third input main pipeline is provided with one or two input pumps.

10. A liquid preparation chromatography system based on a multifunctional automatic pilot platform, characterized in that: The platform system comprises a first input main pipeline with a first input pump and a second input main pipeline with a second input pump; the first input main pipeline is connected to a plurality of input pipelines and is controlled on and off by corresponding valves; the second input main pipeline is also respectively connected to the plurality of input pipelines and is controlled on and off by corresponding valves; the outlet end of each input pipeline is respectively connected to the liquid inlet port of the corresponding movable installation module, and the movable installation module is also provided with a plurality of liquid outlet ports; each of the liquid outlet ports is respectively connected to a plurality of collecting pipelines through an output pipeline; the first input main pipeline is respectively connected to the two collecting pipelines through valves; the second input main pipeline is respectively connected to the plurality of collecting pipelines through valves; the second input main pipeline is connected to the first input main pipeline through a valve; the first input module is connected to an external pump module through a valve; a mixer and a bubble trap are provided on the first input main pipeline; the connection end of the second input main pipeline, the external pump module and the first input main pipeline is located on one side of the inlet end of the mixer; a plurality of chromatography columns are placed in the movable installation module, the bottom inlet and outlet of each chromatography column are connected to the input pipeline through the corresponding liquid inlet port; the top inlet and outlet of the chromatography column are connected to the output pipeline through the corresponding liquid outlet port.

11. The liquid preparation chromatography system based on the multifunctional automatic pilot platform according to claim 10, characterized in that: The input pipelines are provided with two, and the corresponding movable installation module has two liquid inlet ports, two liquid outlet ports, and two output pipelines respectively, and the chromatography columns use one or two.

12. The liquid preparation chromatography system based on the multifunctional automatic pilot platform according to claim 11, characterized in that: The outlet end of the first input main pipeline is connected to the first valve array group, and the first valve array group includes four valves connected end to end to form a rectangular valve array; a group of opposite sides of the rectangular valve array are respectively connected to the outlet end of the first input main pipeline and the outlet of the connecting pipeline; the output end of the connecting pipeline is respectively connected to the multiple collecting pipelines through multiple intermediate pipelines; another group of opposite sides of the rectangular valve array are respectively connected to the inlets of the two input pipelines.

13. The liquid preparation chromatography system based on the multifunctional automatic pilot platform according to claim 11, characterized in that: The second input main pipeline is connected to the output end of the connecting pipeline through a pipeline, and a valve is arranged on the pipeline.

14. The liquid preparation chromatography system based on the multifunctional automatic pilot platform according to claim 11, characterized in that: The input pipeline and the output pipeline are connected one by one through pipelines, and valves are arranged on the pipelines.

15. The liquid preparation chromatography system based on the multifunctional automatic pilot platform according to claim 11, characterized in that: There are two collecting pipes.

16. The liquid preparation chromatography system based on the multifunctional automatic pilot platform according to claim 11, characterized in that: The two output pipes are respectively connected to the second valve array group, which includes four valves connected end to end to form a rectangular valve array; one group of opposite sides of the rectangular valve array corresponds to the outlet ends of the output pipes; the other group of opposite sides of the rectangular valve array corresponds to the inlets of the two collecting pipes.

17. The liquid preparation chromatography system based on the multifunctional automatic pilot platform according to claim 11, characterized in that: In some embodiments, the external pump module includes a third input main pipeline, a plurality of input pumps are disposed at the inlet end of the third input main pipeline, and the third input main pipeline is respectively connected to the first input main pipeline.

18. The liquid preparation chromatography system based on the multifunctional automatic pilot platform according to claim 17, characterized in that: The inlet end of the third input main pipeline is provided with one or two input pumps.

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