Traditional Chinese medicine composition for treating pneumonia and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating pneumonia and a preparation method thereof, and relates to the technical field of traditional Chinese medicines. According to the traditional Chinese medicine composition for treating pneumonia and the preparation method thereof, the traditional Chinese medicine composition for treating pneumonia comprises the following raw materials: honeysuckle, cordyceps militaris, cornu gorais, bear gall powder, fructus forsythiae, astragalus membranaceus, brucea javanica, fructus psoraleae, ginseng, cinnamon, ginger and honey-fried licorice root. Based on traditional Chinese medicine theories and pneumonia pathogenesis characteristics, and on the basis of common honeysuckle, fructus forsythiae and astragalus membranaceus for treating pneumonia, cordyceps militaris, brucea javanica, ginseng, cornu gorais and other traditional Chinese medicine components are added, so that combined use of multiple traditional Chinese medicines is realized; the traditional Chinese medicine composition can improve the treatment effect, clear and moisten lung dryness, improve fever, cough, chest distress, breath promotion and other symptoms of pneumonia patients, is good in safety, has multiple taking forms, and is suitable for most patients to use.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine composition for treating pneumonia and a preparation method thereof. Background Art

[0002] Pneumonia is a very common respiratory infectious disease in clinical practice. Since pneumonia often lacks typical symptoms and signs in the early stage, antibiotic treatment and inappropriate medication after diagnosis often cause pneumonia to linger and even gradually worsen and develop into pneumonia. Pneumonia is the type of pneumonia with the highest mortality rate. Pneumonia is not a very strict disease definition, but a conceptual clinical diagnostic term. There is no accurate definition of pneumonia internationally. Different countries, regions and even hospitals have different definitions of pneumonia according to their own medical level. Pneumonia in a narrow sense generally refers to community-acquired pneumonia, which is generally composed of general bronchitis and bronchiolitis. In a broad sense, pneumonia is composed of community-acquired and hospital-acquired pneumonia. Community-acquired pneumonia refers to pneumonia with clear lung parenchymal inflammation when visiting the hospital, or pneumonia caused by infection with certain pathogens with a clear incubation period and onset within the average incubation period after admission. It is one of the common infectious diseases that threaten people's health. The mortality rate of patients with this disease during hospitalization is about 12.8%; the mortality rate of severe community-acquired pneumonia in the intensive care unit (ICU) is as high as 48%, which is the disease with the highest mortality rate in the ICU. The biggest difference between hospital-acquired pneumonia and community-acquired pneumonia is that the two are acquired at different times. When patients are admitted to the hospital, they are not infected with the relevant pathogens, nor are they in the incubation period of the relevant pathogens. Instead, they develop 48 hours after admission. They are mainly caused by bacteria, followed by fungi, mycoplasmas, viruses or protozoa, and are inflammations of various types of lung parenchyma. A large part of hospital-acquired pneumonia is closely related to cross-infection of patients and irrational use of antibiotics (such as long-term use of a single antibiotic).

[0003] Current clinical research results show that the use of Western medicine hormones and antibiotics to combat organ fibrosis can only play an anti-inflammatory role, and cannot inhibit the development of fibrosis; moreover, long-term and large-dose use of hormones and antibiotics will produce terrible side effects, and even aggravate organ fibrosis. Moreover, although Western medicine is effective quickly, long-term use of hormone drugs will inhibit the body's own hormone secretion and function decline, and it is impossible to recover in a short period of time. It is necessary to rely on the continuous administration of exogenous hormones to ensure the body's normal metabolism and functional activities, forming dependence. Long-term use will cause the gradual loss of organ function.

[0004] Therefore, Chinese medicine can give full play to the advantages of syndrome differentiation and treatment, and has strong targeted treatment for pneumonia, personalized treatment, overall regulation, and enhancement of the body's immune function. Western medicine can only achieve short-term effective relief in the treatment of interstitial pneumonia and pulmonary fibrosis, and cannot cure it fundamentally. Some Chinese herbal medicines will cause damage to the patient's stomach, causing diarrhea and dehydration, resulting in the treatment effect of pneumonia far below the expected standard. Summary of the invention

[0005] In view of the deficiencies in the prior art, the present invention provides a traditional Chinese medicine composition for treating pneumonia and a preparation method thereof, which solves the problems raised in the above-mentioned background technology.

[0006] To achieve the above objectives, the present invention is implemented through the following technical scheme, a Chinese medicine composition for treating pneumonia and a preparation method thereof, wherein the Chinese medicine composition for treating pneumonia comprises the following raw materials: honeysuckle, cordyceps militaris, goat horn, bear bile powder, forsythia, astragalus, brucea javanica, psoralea corylifolia, ginseng, cinnamon, ginger and roasted licorice.

[0007] The pharmaceutical mechanism of the above raw material components is further briefly disclosed, wherein:

[0008] Honeysuckle contains chlorogenic acid, flavonoids, volatile oils, luteolin, saponins, and inositol. It mainly plays an auxiliary role in the treatment of pneumonia, clearing away heat and detoxifying, evacuating wind-heat, and has anti-pathogenic microorganism, antioxidant, and anti-inflammatory effects.

[0009] Cordyceps militaris is sweet and warm in nature. It belongs to the lung meridian and can replenish qi. Taking it in moderation can replenish the lungs and relieve asthma. The cordycepin in it can kill tuberculosis bacteria, and cordycepic acid and cordyceps polysaccharides can promote the repair of damaged lung cells as soon as possible. It is often used to treat diseases such as tuberculosis and chronic bronchial pneumonia.

[0010] Goat horn can resolve phlegm and relieve cough, and has a good relieving effect on people with symptoms such as cough, dry throat, hoarseness, etc. According to Chinese medicine theory, goat horn tastes bitter and pungent, is warm in nature, and belongs to the lung, heart, and liver meridians. It has the effects of warming the middle and lowering qi, resolving phlegm and relieving cough, nourishing yin and moistening dryness, etc. Therefore, it is widely used in the treatment of long-term cough, asthma, chronic bronchitis and other diseases;

[0011] Bear bile powder is cold in nature and bitter in taste. It can be used in the liver, gallbladder and heart meridians. The chenodeoxycholic acid, bile acid and deoxycholic acid it contains have detoxifying, antibacterial and anti-inflammatory effects, especially for Staphylococcus aureus, Streptococcus and Pneumococcus.

[0012] The chemical components of Forsythia suspensa include phenylethanol glycosides, lignans, terpenes, flavonoids, phenolic acids, etc., which are the main active ingredients. They have antibacterial, anti-inflammatory, antiviral, anti-tumor, antipyretic and other pharmacological effects. They are also commonly used drugs in the treatment of pneumonia.

[0013] Astragalus contains amino acids, polysaccharides and astragaloside IV, which can improve the body's immunity and are helpful for the prevention and treatment of pneumonia. It also has antioxidant and anti-inflammatory properties and can inhibit lung inflammation caused by Klebsiella pneumoniae.

[0014] Brucea javanica is bitter in taste and cold in nature. It enters the liver, gallbladder, and lung meridians and has the effect of clearing away heat and detoxifying. It can relieve symptoms such as sore throat, lung heat cough, etc. caused by heat and toxins.

[0015] Psoralea corylifolia can increase myocardial nutrition and blood flow, and when used in combination with the other components mentioned above, it can moisten the lungs and relieve coughs, and has a certain therapeutic effect on coughs, asthma, pharyngeal phlegm, and pneumonia caused by dry lungs or lung heat.

[0016] Ginsenosides and ginseng polysaccharides contained in ginseng can enhance the body's immune function and help improve the patient's ability to fight pneumonia virus. Here, ginseng is used as an auxiliary drug to improve the therapeutic effect.

[0017] Cinnamon bark is rich in cinnamon oil, which is excreted through the lungs after being ingested by the human body. In the process, it can effectively promote the dilution of mucus, so the symptoms of coughing due to excessive phlegm can be alleviated a lot, so it can be used in combination with other drugs as an auxiliary medicine.

[0018] Licorice root can relieve cough and expectoration, moisturize the lungs, and improve the symptoms of cough and expectoration caused by respiratory tract infections. Secondly, it can also replenish qi and relieve body pain. Licorice root has a mild property and has a nourishing effect on the spleen and stomach after taking it.

[0019] A further improvement of the technical solution of the present invention is that the raw materials include the following components by weight: 17-24 parts of honeysuckle, 10-18 parts of cordyceps militaris, 4-12 parts of goat horn, 3-9 parts of bear bile powder, 1-5 parts of forsythia, 4-14 parts of astragalus, 5-7 parts of brucea javanica, 2-5 parts of psoralea corylifolia, 7-15 parts of ginseng, 6-9 parts of cinnamon, 5-11 parts of ginger and 6-13 parts of licorice.

[0020] A further improvement of the technical solution of the present invention is that the Chinese medicine composition can receive appropriate pharmaceutical excipients and be produced into any one of injection, powder injection, lyophilized powder injection, tablets, capsules, granules, oral liquid, pills or sustained-release preparations.

[0021] A further improvement of the technical solution of the present invention is that a specific preparation method of a Chinese medicine composition for treating pneumonia is also provided, comprising the following steps:

[0022] S1: The mixed extract of honeysuckle, Cordyceps militaris, Astragalus membranaceus, Brucea javanica, the mixed extract of goat horn and bear bile powder, and the mixed extract of Forsythia suspensa, Psoralea corylifolia, Ginseng, Cinnamon bark, ginger and Radix glycyrrhizae are respectively concentrated under reduced pressure to a thick paste with a relative density of 1.34 at 50°C, 95% ethanol is added to the obtained thick paste to make the alcohol content reach 68% to 78%, and the mixture is stirred at high speed for 30min-45min and allowed to stand at room temperature for 24h;

[0023] S2: The three thick pastes obtained in S1 are mixed, and ethanol is recovered. The mixed thick paste is granulated by a granulator, and dried at 70°C. The granular powder is sieved through an 80-mesh sieve to remove the fine powder component. The sieved granular powder is transferred to a sealed container and allowed to stand. After standing, ethanol is sprayed on the surface. After mixing and drying, a Chinese medicine composition is obtained.

[0024] A further improvement of the technical solution of the present invention is that the preparation process of the mixed extract of honeysuckle, cordyceps militaris, astragalus and brucea javanica includes the following specific steps: taking appropriate amounts of honeysuckle, cordyceps militaris, brucea javanica and astragalus, adding 10 times the amount of water and boiling for 1 hour, after preliminary filtration, adding 5 times the amount of water to the residue and boiling for 30 minutes, filtering twice, combining the filtrate obtained by the two filtrations and concentrating to 4-5 times the amount of the medicinal materials, adding 20% ​​lime milk, adjusting the pH to 7, filtering to obtain a precipitate, adding 2 times the amount of ethanol to the precipitate for suspension, adjusting the pH to 3-4 with 50% H2SO4, filtering with sufficient stirring, neutralizing the filtrate with 40% NaOH to a pH of 7.0, recovering ethanol after filtration, concentrating to a relative density to obtain a thick paste, adding water for final filtration, and obtaining a mixed extract of honeysuckle, cordyceps militaris, brucea javanica and astragalus after filtration, which is retained for later use.

[0025] A further improvement of the technical solution of the present invention is that the preparation process of the mixed extract of goat horn and bear bile powder includes the following specific steps: taking an appropriate amount of goat horn and bear bile powder and grinding them into powder, adding 6wt-10wt times of 8mol / L HCl, heating to 100-110°C and reflux hydrolysis for 20 hours until the hydrolysis is completed and there are no medicinal material particles, cooling to room temperature, filtering to obtain a precipitate, washing the obtained precipitate with an appropriate amount of purified water, combining the hydrolyzate of the filtrate and the washing liquid, slowly adding 95% ethanol solution to the obtained hydrolyzate during stirring so that the alcohol content of the mixed solution reaches 55%-65%, refrigerating at 5°C for 12 hours, taking out and filtering to recover ethanol, concentrating to a relative density to obtain a thick paste, and refrigerating at 0-10°C for 12 hours for standby use.

[0026] A further improvement of the technical solution of the present invention is that the preparation process of the mixed extract of Forsythia suspensa, Psoralea corylifolia, ginseng, cinnamon, ginger and licorice root comprises the following specific steps: taking appropriate amounts of Forsythia suspensa, Psoralea corylifolia, ginseng, cinnamon, ginger and licorice root, adding appropriate amounts of water for decoction, cyclic extraction for 3 times, each time for 2 hours, finally combining the decoctions, filtering to obtain an extract, decompressing and concentrating the extract at 55°C to a relative density to obtain a thick paste, then adding 4 times the amount of ethanol, stirring evenly and standing for 2 hours, filtering after precipitation for 30 minutes, decompressing the filtrate to recover ethanol to obtain a concentrated solution, and retaining it for later use.

[0027] A further improvement of the technical solution of the present invention is that the relative density of the mixed extract of honeysuckle, Cordyceps militaris, Astragalus membranaceus and Brucea javanica is 1.05-1.09 during the preparation process, the relative density of the mixed extract of goat horn and bear bile powder is concentrated to 1.08-1.10 during the preparation process, and the relative density of the mixed extract of Forsythia suspensa, Psoralea corylifolia, ginseng, cinnamon, ginger and licorice is concentrated to 1.10-1.20.

[0028] Compared with the prior art, the beneficial effect of the present invention is that, based on the theory of traditional Chinese medicine and the characteristics of pneumonia onset, and on the basis of honeysuckle, forsythia and astragalus commonly used in the treatment of pneumonia, Chinese medicinal components such as Cordyceps militaris, Brucea javanica, ginseng and goat horn are added to achieve the combined use of multiple Chinese medicinal drugs, which improves the therapeutic effect while clearing away lung dryness, improving the symptoms of fever, cough, chest tightness and shortness of breath in patients with pneumonia, has good safety, has a variety of dosage forms, and is suitable for most patients. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1 A schematic diagram of a process for preparing a Chinese medicine composition for treating pneumonia;

[0030] Figure 2 This is a digital integration result diagram of the experimental group A and the experimental group B before and after treatment in Example 2. DETAILED DESCRIPTION

[0031] Various exemplary embodiments, features and aspects of the present application will be described in detail below with reference to the accompanying drawings. The same reference numerals in the accompanying drawings represent elements with the same or similar functions. Although various aspects of the embodiments are shown in the accompanying drawings, the drawings are not necessarily drawn to scale unless otherwise specified.

[0032] The word “exemplary” is used exclusively herein to mean “serving as an example, example, or illustration.” Any embodiment described herein as “exemplary” is not necessarily to be construed as preferred or advantageous over other embodiments.

[0033] In addition, in order to better illustrate the present application, numerous specific details are provided in the specific embodiments below. It should be understood by those skilled in the art that the present application can also be implemented without certain specific details. In some examples, methods, means, and elements well known to those skilled in the art are not described in detail in order to highlight the subject matter of the present application.

[0034] The invention provides a traditional Chinese medicine composition for treating pneumonia, comprising honeysuckle, cordyceps militaris, goat horn, bear gall powder, forsythia, astragalus, brucea javanica, psoralea corylifolia, ginseng, cinnamon bark, ginger and roasted liquorice.

[0035] The drug mechanism of the above raw material components is further briefly disclosed, wherein:

[0036] Honeysuckle contains chlorogenic acid, flavonoids, volatile oils, luteolin, saponins, and inositol. It mainly plays an auxiliary role in the treatment of pneumonia, clearing away heat and detoxifying, evacuating wind-heat, and has anti-pathogenic microorganism, antioxidant, and anti-inflammatory effects.

[0037] Cordyceps militaris is sweet and warm in nature. It belongs to the lung meridian and can replenish qi. Taking it in moderation can replenish the lungs and relieve asthma. The cordycepin in it can kill tuberculosis bacteria, and cordycepic acid and cordyceps polysaccharides can promote the repair of damaged lung cells as soon as possible. It is often used to treat diseases such as tuberculosis and chronic bronchial pneumonia.

[0038] Goat horn is bitter and cold in nature. It enters the liver and kidney meridians and has the effects of clearing heat, cooling blood, detoxifying, calming the liver and relieving pain. It can be used clinically to relieve symptoms such as dizziness, red and swollen eyes, photophobia, excessive tears, headache and dizziness caused by hyperactivity of liver yang and liver fire. It can also be used to treat heat-toxic bloody diarrhea, vomiting blood and epistaxis caused by hyperactivity of liver yang and liver fire.

[0039] Bear bile powder is cold in nature and bitter in taste. It can be used in the liver, gallbladder and heart meridians. The chenodeoxycholic acid, bile acid and deoxycholic acid it contains have detoxifying, antibacterial and anti-inflammatory effects, especially for Staphylococcus aureus, Streptococcus and Pneumococcus.

[0040] The chemical components of Forsythia suspensa include phenylethanol glycosides, lignans, terpenes, flavonoids, phenolic acids, etc., which are the main active ingredients. They have antibacterial, anti-inflammatory, antiviral, anti-tumor, antipyretic and other pharmacological effects. They are also commonly used drugs in the treatment of pneumonia.

[0041] Astragalus contains amino acids, polysaccharides and astragaloside IV, which can improve the body's immunity and are helpful for the prevention and treatment of pneumonia. It also has antioxidant and anti-inflammatory properties and can inhibit lung inflammation caused by Klebsiella pneumoniae.

[0042] Brucea javanica is bitter in taste and cold in nature. It enters the liver, gallbladder, and lung meridians and has the effect of clearing away heat and detoxifying. It can relieve symptoms such as sore throat, lung heat cough, etc. caused by heat and toxins.

[0043] Psoralea corylifolia can increase myocardial nutrition and blood flow, and when used in combination with the other components mentioned above, it can moisten the lungs and relieve coughs, and has a certain therapeutic effect on coughs, asthma, pharyngeal phlegm, and pneumonia caused by dry lungs or lung heat.

[0044] Ginsenosides and ginseng polysaccharides contained in ginseng can enhance the body's immune function and help improve the patient's ability to fight pneumonia virus. Here, ginseng is used as an auxiliary drug to improve the therapeutic effect.

[0045] Cinnamon bark is rich in cinnamon oil, which is excreted through the lungs after being ingested by the human body. In the process, it can effectively promote the dilution of mucus, so the symptoms of coughing due to excessive phlegm can be alleviated a lot, so it can be used in combination with other drugs as an auxiliary medicine.

[0046] Licorice root can relieve cough and expectoration, moisturize the lungs, and improve the symptoms of cough and expectoration caused by respiratory tract infections. Secondly, it can also replenish qi and relieve body pain. Licorice root has a mild property and has a nourishing effect on the spleen and stomach after taking it.

[0047] 17-24 parts of honeysuckle, 10-18 parts of cordyceps militaris, 4-12 parts of goat horn, 3-9 parts of bear bile powder, 1-5 parts of forsythia, 4-14 parts of astragalus, 5-7 parts of brucea javanica, 2-5 parts of psoralea corylifolia, 7-15 parts of ginseng, 6-9 parts of cinnamon, 5-11 parts of ginger and 6-13 parts of roasted liquorice.

[0048] The Chinese medicine composition can be prepared into any one of injection, powder injection, lyophilized powder injection, tablet, capsule, granule, oral solution, pill or sustained-release preparation by receiving appropriate pharmaceutical excipients.

[0049] Embodiment 1: The present invention also provides a method for preparing a Chinese medicine composition for treating pneumonia, comprising the following specific steps:

[0050] S1: The mixed extract of honeysuckle, Cordyceps militaris, Astragalus membranaceus, Brucea javanica, the mixed extract of goat horn and bear bile powder, and the mixed extract of Forsythia suspensa, Psoralea corylifolia, Ginseng, Cinnamon bark, ginger and Radix glycyrrhizae are respectively concentrated under reduced pressure to a thick paste with a relative density of 1.34 at 50°C, 95% ethanol is added to the obtained thick paste to make the alcohol content reach 68% to 78%, and the mixture is stirred at high speed for 30min-45min and allowed to stand at room temperature for 24h;

[0051] S2: The three thick pastes obtained in S1 are mixed, and ethanol is recovered. The mixed thick paste is granulated by a granulator, and dried at 70°C. The granular powder is sieved through an 80-mesh sieve to remove the fine powder component. The sieved granular powder is transferred to a sealed container and allowed to stand. After standing, ethanol is sprayed on the surface. After mixing and drying, a Chinese medicine composition is obtained.

[0052] The preparation process of the mixed extract of honeysuckle, Cordyceps militaris, Astragalus membranaceus and Brucea javanica includes the following specific steps: taking appropriate amounts of honeysuckle, Cordyceps militaris, Brucea javanica and Astragalus membranaceus, adding 10 times the amount of water and boiling for 1 hour, after preliminary filtration, adding 5 times the amount of water to the residue and boiling for 30 minutes, filtering for a second time, combining the filtrate obtained from the two filtrations and concentrating it to 4-5 times the amount of the medicinal materials, adding 20% ​​lime milk, adjusting the pH to 7, filtering to obtain a precipitate, suspending the precipitate in 2 times the amount of ethanol, adjusting the pH to 3-4 with 50% H2SO4, filtering with sufficient stirring, neutralizing the filtrate with 40% NaOH to a pH of 7.0, recovering ethanol after filtration, concentrating to a relative density to obtain a thick paste, adding water for final filtration, and obtaining a mixed extract of honeysuckle, Cordyceps militaris, Brucea javanica and Astragalus membranaceus after filtration, which is retained for later use.

[0053] The preparation process of the mixed extract of goat horn and bear bile powder includes the following specific steps: taking an appropriate amount of goat horn and bear bile powder and grinding them into powder, adding 6wt-10wt times of 8mol / L HCl, heating to 100-110℃ and reflux hydrolysis for 20h, until the hydrolysis is completed and there are no medicinal material particles, cooling to room temperature, filtering to obtain a precipitate, washing the obtained precipitate with an appropriate amount of purified water, combining the hydrolyzate of the filtrate and the washing liquid, slowly adding 95% ethanol solution to the obtained hydrolyzate during stirring so that the alcohol content of the mixed solution reaches 55%-65%, refrigerating at 5℃ for 12h, taking out and filtering to recover ethanol, concentrating to a relative density to obtain a thick paste, refrigerating at 0-10℃ for 12h and then setting aside.

[0054] The preparation process of the mixed extract of Forsythia suspensa, Psoralea corylifolia, ginseng, cinnamon, ginger and licorice root includes the following specific steps: taking appropriate amounts of Forsythia suspensa, Psoralea corylifolia, ginseng, cinnamon, ginger and licorice root, adding appropriate amounts of water for decoction, cyclic extraction for 3 times, each time for 2 hours, finally combining the decoctions, filtering to obtain an extract, decompressing and concentrating the extract at 55°C to a relative density to obtain a thick paste, then adding 4 times the amount of ethanol, stirring evenly and standing for 2 hours, filtering after precipitation for 30 minutes, decompressing the filtrate to recover the ethanol to obtain a concentrated solution, and retaining it for later use.

[0055] The relative density of the mixed extract of honeysuckle, cordyceps militaris, astragalus and Brucea javanica is 1.05-1.09 during the preparation process, the relative density of the mixed extract of goat horn and bear bile powder is concentrated to 1.08-1.10 during the preparation process, and the relative density of the mixed extract of forsythia, psoralea corylifolia, ginseng, cinnamon, ginger and licorice is concentrated to 1.10-1.20.

[0056] Example 2: The patients included in the case were subjected to a randomized controlled clinical trial, and were divided into an experimental group and a control group with 50 cases in each group. In order to obtain the test results more intuitively in the later stage, the different degrees of the disease were divided based on numerical scores, wherein the scores of each item before treatment for severe disease were ≥20, the scores of each item before treatment for moderate disease were in the range of 14-19, and the scores of each item before treatment for mild disease were <14 points;

[0057] The experimental group A took the Chinese medicine composition obtained in Example 1 by injection or oral administration, plus basic treatment for pneumonia;

[0058] Experimental group B received intravenous saline and glucose plus basal therapy;

[0059] The treatment course of both experimental group A and experimental group B was controlled to 10 days;

[0060] The clinical efficacy judgment standard is judged in accordance with the "Guiding Principles for Clinical Research of New Chinese Medicines". For the convenience of judgment, after 10 days of treatment, the main symptoms and signs of pneumonia disappear, other indicators return to normal, and the total score before and after treatment decreases by 90% or more, which is a significant effect; after 10 days of treatment, the main symptoms and signs of pneumonia are relieved, other indicators return to normal, and the total score before and after treatment is reduced by 70% to 89%, which is a therapeutic effect; after 10 days of treatment, the main symptoms and signs of pneumonia are improved, other indicators are improved, and the total score before and after treatment is reduced by 30% to 69% or more, which is a general efficacy;

[0061] The scoring criteria for the disease are:

[0062] A temperature of ≥39.5°C is 4 points, a temperature of 38.5°C-39.4°C is 3 points, a temperature of 37.3°C-38.4°C is 2 points, and a temperature of <37°C is 0 points;

[0063] Sputum color: 4 points for yellow and thick sputum or sputum with foul odor or blood, 3 points for yellow, white or sticky sputum, 2 points for white or thin sputum, and 0 points for normal.

[0064] Frequent coughing or paroxysmal coughing during the day and night that affects rest and sleep is 4 points, moderate cough is 3 points, indirect cough is 2 points, and no cough is 0 points;

[0065] 2 points for obvious asthma that affects sleep and activities, 1 point for occasional asthma that does not affect sleep and activities, and 0 points for no asthma;

[0066] Dry or moist rales on lung auscultation were scored as 2 points, low breath sounds were scored as 1 point, and normal breath sounds were scored as 0 points.

[0067] Red tongue with yellow coating was 1 point, pale red tongue with thin white coating was 0 point;

[0068] A floating, slippery, or stringy pulse was scored as 1 point, and a calm pulse was scored as 0 points;

[0069] X-ray results showing inflammatory lesions were scored as 2 points, and non-inflammatory lesions were scored as 0 points;

[0070] WBC ≥ 10 × 10 9 / L or N ≥ 75% is 2 points, normal is 0 points;

[0071] In order for the clinical manifestations to tend to be between the two integral manifestations, the selection is made based on the specific clinical symptoms within the curve and retaining two decimal places. The clinical trial results are shown in the attached figure.

[0072] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprises" or any other variations thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device.

[0073] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A Chinese medicine composition for treating pneumonia, characterized in that: The traditional Chinese medicine composition for treating pneumonia comprises the following raw materials: honeysuckle, cordyceps militaris, goat horn, bear bile powder, forsythia, astragalus, brucea javanica, psoralea corylifolia, ginseng, cinnamon bark, ginger and roasted licorice.

2. A Chinese medicine composition for treating pneumonia according to claim 1, characterized in that: The raw materials include the following components by weight: 17-24 parts of honeysuckle, 10-18 parts of cordyceps militaris, 4-12 parts of goat horn, 3-9 parts of bear bile powder, 1-5 parts of forsythia, 4-14 parts of astragalus, 5-7 parts of brucea javanica, 2-5 parts of psoralea corylifolia, 7-15 parts of ginseng, 6-9 parts of cinnamon, 5-11 parts of ginger and 6-13 parts of licorice.

3. A Chinese medicine composition for treating pneumonia according to claim 1, characterized in that: The Chinese medicine composition can be prepared into any one of injection, powder injection, lyophilized powder injection, tablet, capsule, granule, oral solution, pill or sustained-release preparation by receiving appropriate pharmaceutical excipients.

4. The method for preparing a traditional Chinese medicine composition for treating pneumonia according to claim 1, characterized in that: The preparation of the Chinese medicine composition comprises the following specific steps: S1: The mixed extract of honeysuckle, Cordyceps militaris, Astragalus membranaceus, Brucea javanica, the mixed extract of goat horn and bear bile powder, and the mixed extract of Forsythia suspensa, Psoralea corylifolia, Ginseng, Cinnamon bark, ginger and Radix glycyrrhizae are respectively concentrated under reduced pressure to a thick paste with a relative density of 1.34 at 50°C, 95% ethanol is added to the obtained thick paste to make the alcohol content reach 68% to 78%, and the mixture is stirred at high speed for 30min-45min and allowed to stand at room temperature for 24h; S2: The three thick pastes obtained in S1 are mixed, and ethanol is recovered. The mixed thick paste is granulated by a granulator, and dried at 70°C. The granular powder is sieved through an 80-mesh sieve to remove the fine powder component. The sieved granular powder is transferred to a sealed container and allowed to stand. After standing, ethanol is sprayed on the surface. After mixing and drying, a Chinese medicine composition is obtained.

5. The method for preparing a traditional Chinese medicine composition for treating pneumonia according to claim 4, characterized in that: The preparation process of the mixed extract of honeysuckle, Cordyceps militaris, Astragalus membranaceus and Brucea javanica includes the following specific steps: taking appropriate amounts of honeysuckle, Cordyceps militaris, Brucea javanica and Astragalus membranaceus, adding 10 times the amount of water and boiling for 1 hour, after preliminary filtration, adding 5 times the amount of water to the residue and boiling for 30 minutes, filtering for a second time, combining the filtrate obtained from the two filtrations and concentrating it to 4-5 times the amount of the medicinal materials, adding 20% ​​lime milk, adjusting the pH to 7, filtering to obtain a precipitate, suspending the precipitate in 2 times the amount of ethanol, adjusting the pH to 3-4 with 50% H2SO4, filtering with sufficient stirring, neutralizing the filtrate with 40% NaOH to a pH of 7.0, recovering ethanol after filtration, concentrating to a relative density to obtain a thick paste, adding water for final filtration, and obtaining a mixed extract of honeysuckle, Cordyceps militaris, Brucea javanica and Astragalus membranaceus after filtration, which is retained for later use.

6. The method for preparing a traditional Chinese medicine composition for treating pneumonia according to claim 5, characterized in that: The preparation process of the mixed extract of goat horn and bear bile powder includes the following specific steps: taking appropriate amounts of goat horn and bear bile powder and grinding them into powder, adding 6wt-10wt times of 8mol / L HCl, heating to 100-110°C for reflux hydrolysis for 20 hours, until the hydrolysis is completed and there are no medicinal material particles, cooling to room temperature, filtering to obtain a precipitate, washing the obtained precipitate with an appropriate amount of purified water, combining the hydrolyzate of the filtrate and the washing liquid, slowly adding 95% ethanol solution to the obtained hydrolyzate during stirring so that the alcohol content of the mixed solution reaches 55%-65%, refrigerating at 5°C for 12 hours, taking out and filtering to recover ethanol, concentrating to a relative density to obtain a thick paste, refrigerating at 0-10°C for 12 hours and then setting aside.

7. The method for preparing a traditional Chinese medicine composition for treating pneumonia according to claim 6, characterized in that: The preparation process of the mixed extract of Forsythia suspensa, Psoralea corylifolia, ginseng, cinnamon, ginger and licorice root includes the following specific steps: taking appropriate amounts of Forsythia suspensa, Psoralea corylifolia, ginseng, cinnamon, ginger and licorice root, adding appropriate amounts of water for decoction, cyclic extraction for 3 times, each time for 2 hours, finally combining the decoctions, filtering to obtain an extract, decompressing and concentrating the extract at 55°C to a relative density to obtain a thick paste, then adding 4 times the amount of ethanol, stirring evenly and standing for 2 hours, filtering after precipitation for 30 minutes, decompressing the filtrate to recover the ethanol to obtain a concentrated solution, and retaining it for later use.

8. The method for preparing a traditional Chinese medicine composition for treating pneumonia according to claim 7, characterized in that: The relative density of the mixed extract of honeysuckle, cordyceps militaris, astragalus and Brucea javanica is 1.05-1.09 during the preparation process, the relative density of the mixed extract of goat horn and bear bile powder is concentrated to 1.08-1.10 during the preparation process, and the relative density of the mixed extract of forsythia, psoralea corylifolia, ginseng, cinnamon, ginger and licorice is concentrated to 1.10-1.20.

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