Flow chemistry intelligent experiment platform

Abstract

The invention discloses a flow chemistry intelligent experiment platform which comprises a direct-current constant-voltage power supply, a PC, a main control board, an electric energy metering module, a temperature control module, an electromagnetic valve, a stepping motor, a flow chemistry unit and an image sensor. The PC is provided with a webpage operation end, a control instruction is transmitted to the main control board through the gigabit Ethernet, and the main control board adopts a hardware architecture of FPGA and ARM co-processing and can accurately control devices such as an electromagnetic valve and a stepping motor to carry out experiments according to set reaction conditions; and in the reaction process, images acquired by the sensor and experimental data such as temperature, pressure, pH and the like are synchronously transmitted to the PC through the main control board to be displayed, analyzed and stored. The device provides maximum flexibility for the flowing chemical reaction, realizes integrated control of various reaction conditions such as temperature, pressure, pH and flow velocity, has the advantages of reasonable structure, high degree of freedom, good interactive experience and the like, and is suitable for various scenes such as classroom experiment teaching, student exploration experiment, college laboratory scientific research and the like.

Description

Technical Field

[0001] The present invention relates to the field of continuous flow chemistry and automated control technology, and in particular to a flow chemistry intelligent experimental platform suitable for automated control of reaction conditions and data acquisition and analysis in flow chemistry experiments. Background Art

[0002] Flow chemistry, also known as continuous flow chemistry, refers to chemical reaction equipment and methods that involve two or more streams of different reactants pumped into a single chamber, tube or microreactor at a specific flow rate. After the reaction is completed, the stream containing the resulting compound is collected at the outlet, or directed to a subsequent flow reactor loop for further reaction to obtain the final product. Flow chemistry has significant advantages in terms of safety, environmental protection, chemical selectivity, etc., and has been widely used in many fields such as pharmaceuticals and fine chemicals. However, the popularity of the concept of flow chemistry in the field of chemical education has not kept up, and traditional intermittent reaction methods are still mostly used for experiments. Considering the growing demand for efficient, safe, and green chemistry in chemical research and industrial production, it is particularly important to introduce flow chemistry knowledge in experimental teaching and to practice with flow chemistry experimental platforms.

[0003] The key points that need to be solved in the flow chemistry experimental platform are: first, to build a highly universal and easy-to-operate system, and through the replaceable module design, it can be compatible with a variety of reactants, reaction types and reaction conditions, ensuring that the switching between different experiments is simple and efficient, and meeting the needs of teaching for the demonstration and exploration of various reaction types; second, to ensure the coordinated improvement of automation and safety, and to accurately set and adjust the reaction parameters, and to provide real-time feedback on the reaction process and result data, so that students can deeply understand the reaction principles and influencing factors, and embed multiple safety monitoring and protection mechanisms to ensure that the experimental process can run safely and reliably when no one is directly monitoring; third, to design a controller with high functional expandability. Build an open programming interface and a modular functional architecture to facilitate the subsequent addition of new control algorithms, data processing functions, and connection to other devices for post-processing. Summary of the invention

[0004] The purpose of the present invention is to provide a flow chemistry intelligent experimental platform for the needs of modern chemical teaching and scientific research. The present invention integrates a DC constant voltage power supply, a PC, a main control board, an electric energy metering module, a temperature control module, a solenoid valve, a stepper motor, a flow chemistry unit and an image sensor. In the present invention, the PC is equipped with a web page operation terminal, and the control command is issued to the main control board through Gigabit Ethernet. The main control board adopts a hardware architecture of FPGA and ARM collaborative processing, which can accurately control the solenoid valve, stepper motor and other devices to perform experiments according to the set reaction conditions. During the reaction, the image collected by the sensor and the experimental data such as temperature, pressure, pH, etc. will also be synchronously transmitted to the PC through the main control board for display, analysis and preservation. The present invention provides maximum flexibility for flow chemistry reactions, realizes integrated control of multiple reaction conditions such as temperature, pressure, pH, flow rate, etc., and has the advantages of reasonable structure, high degree of freedom and good interactive experience.

[0005] The specific technical solution for achieving the purpose of the present invention is: A flow chemistry intelligent experiment platform, the platform comprises a DC constant voltage power supply, a PC, a main control board, an electric energy metering module, a temperature control module, a solenoid valve, a stepping motor, a flow chemistry unit and an image sensor; The DC constant voltage power supply is connected to the main control board and the electric energy metering module to directly or indirectly provide the power required for normal operation; The PC is connected to the main control board and the image sensor, and serves as a host computer to realize interactive operations with the user. The PC is configured with a front-end webpage operation page and a back-end database, sends control instructions to the main control board through Gigabit Ethernet and receives the status information and data returned by the main control board, and obtains the image information collected by the image sensor through the USB interface and displays and stores it; The main control board is connected to a DC constant voltage power supply, a PC, an electric energy metering module, a temperature control module, a solenoid valve, a stepper motor and a flow chemistry unit to receive and analyze control instructions issued by the PC, drive the electric energy metering module, the temperature control module, the solenoid valve, the stepper motor and the flow chemistry unit to operate according to the instructions, thereby controlling the reaction conditions and process, and sending the collected data information to the PC in a format required by a custom communication protocol; The electric energy metering module is connected to a DC constant voltage power supply and a main control board, is powered by a DC constant voltage power supply, receives instructions from the main control board, dynamically monitors the total current and total voltage, and transmits the current and voltage data back to the main control board for processing; The temperature control module is connected to the main control board and is closely attached to the back of the microfluidic chip in the flow chemistry unit, and is used to receive parameter setting and data reading instructions from the main control board, heat the microfluidic chip in the flow chemistry unit to the target temperature at a set heating speed, and then maintain the temperature. The temperature data during the experiment is sampled and transmitted back to the main control board in real time, so as to realize the temperature control of the flow chemistry unit and meet the flow chemistry reactions under different temperature conditions; The solenoid valve is connected to the main control board and the flow chemical unit to receive channel setting and switching instructions from the main control board and control the switching of reactants, cleaning agents and products between different flow chemical reaction channels; The stepper motor is connected to the main control board and the flow chemical unit to receive the motor parameter settings and driving instructions from the main control board, and feed back the motor parameter data to the main control board in real time, and control the precise absorption and injection of reactants and cleaning agents in the flow chemical unit through the direction, speed, and moving distance of the two-phase four-wire stepper motor; The flow chemistry unit is connected to the main control board, the temperature control module, the solenoid valve and the stepper motor. The internal parts of the flow chemistry unit are connected by Teflon tubes to form a reaction path of the flow chemistry reaction. At the same time, the main control board, the temperature control module, the solenoid valve and the stepper motor are electrically connected to exchange instructions and data, so that the experiment can be carried out according to the control instructions and the reaction process. The image sensor is connected to a PC to collect real-time images of the reaction process and transmit them to the PC in the form of video for display and storage; wherein: The main control board includes a DC-DC voltage conversion module, an Ethernet interface, a main control unit, a configuration module, an electric energy measurement communication module, a heating plate drive module, an analog-to-digital conversion ADC module, a pressure sensor communication module, a valve control module, and a motor drive module; The DC-DC voltage conversion module is connected to the DC constant voltage power supply, the heating plate driving module, the motor driving module, the electric energy metering module and the flow chemical unit to convert the 24V voltage output by the DC constant voltage power supply into a 12V voltage for the heating plate driving module, the motor driving module, the electric energy metering module and the pressure sensor in the flow chemical unit to work normally; The Ethernet interface is connected to the PC and the main control unit, and serves as a physical carrier for communication between the PC and the main control unit, and is used to issue control instructions from the PC and upload data and status information collected by the main control unit; The main control unit includes a field programmable gate array FPGA chip and an advanced reduced instruction set machine ARM chip, which are connected to the Ethernet interface, configuration module, power measurement communication module, heating plate drive module, ADC module, pressure sensor communication module, valve control module, motor drive module and flow chemistry unit. The FPGA is responsible for parsing, encapsulating and sending and receiving UDP data packets to manage the two-way data communication between the Ethernet interface and the ARM chip, and can store the startup mode and configuration information to the configuration module; the ARM chip is used to parse the control instructions sent by the FPGA chip to realize the initialization and regulation of the power measurement communication module, the heating plate drive module, the ADC module, the pressure sensor communication module, the valve control module and the motor drive module, and collect them to The current, voltage, temperature, pressure, motor parameter data and product pH data collected in the flow chemistry unit are returned to the FPGA chip. The motor parameter information after abnormal power failure will be stored in the configuration module for restoring the motor position after power-on. After normal startup, the FPGA chip continuously monitors the UDP data packet from the Ethernet interface. Once the packet header that conforms to the custom communication protocol is identified, the instruction information is extracted and passed to the ARM chip. The ARM chip parses the instruction content according to the custom communication protocol, drives the corresponding module to run according to the instruction, and collects the required data and packages it in the data format specified by the custom communication protocol and sends it to the FPGA chip. The FPGA chip then encapsulates the data replied by the ARM chip into a User Datagram Protocol UDP data packet and sends it to the Ethernet interface. The configuration module includes a JTAG interface, a flash memory and an electrically erasable programmable read-only memory (EEPROM), which are connected to the main control unit to select a startup mode, a curing program and store configuration parameters; The electric energy measurement communication module is connected to the main control unit and the electric energy metering module, communicates with the electric energy metering module through the RS485 bus, collects the total voltage and total current in real time, and transmits them to the main control unit for processing; The heating plate driving module is connected to the DC-DC voltage conversion module, the main control unit and the temperature control module, and is used to perform level conversion and drive capability enhancement on the pulse width modulation PWM wave output by the ARM chip pin in the main control unit, thereby controlling the heating plate in the temperature control module to heat according to the set temperature and speed to achieve the reaction temperature condition; The ADC module is connected to the main control unit and the temperature control module, converts the resistance change of the temperature sensor in the temperature control module into a voltage change, and conditions the voltage signal so that the ARM chip in the main control unit can correctly collect the current reaction temperature data; The pressure sensor communication module is connected to the main control unit and the flow chemistry unit, communicates with the pressure sensor in the flow chemistry unit via the RS485 bus, collects the pressure data of the current reaction in real time, and transmits it to the main control unit for processing; The valve control module is connected to the DC constant voltage power supply, the main control unit and the solenoid valve to control the on and off of different channels of the solenoid valve; The motor drive module is connected to the DC-DC voltage conversion module, the main control unit and the stepper motor, performs level conversion and driving capability enhancement on the control signal output by the ARM chip pin in the main control unit, and realizes precise control of the running direction, speed and number of steps of the stepper motor through the subdivision drive of the motor drive chip.

[0006] The temperature control module includes a positive temperature coefficient PTC heating plate and a platinum resistance PT1000 temperature sensor; The PTC heating plate is connected to the heating plate driving module and the flow chemistry unit to heat the reaction system in the flow chemistry unit to a target temperature at a set speed; The PT1000 temperature sensor is connected to the ADC module and the flow chemistry unit to control the temperature of the reaction system in the flow chemistry unit so that the reaction can be carried out at any temperature within the range of 25-200°C.

[0007] The flow chemistry unit includes a syringe pump, a pressure sensor, a microfluidic chip, a pH sensor module and a back pressure valve; The injection pump is connected to the pressure sensor through a Teflon tube, and is electrically connected to the electromagnetic valve and the stepper motor. Through the switching of the electromagnetic valve and the forward and reverse rotation of the stepper motor, the reaction solution or the cleaning reagent can be sucked and injected to deliver the liquid to the chemical reaction passage. The pressure sensor is connected to the syringe pump and the microfluidic chip through a Teflon tube, and is electrically connected to the DC-DC voltage conversion module and the pressure sensor communication module to monitor the real-time pressure in the flow chemistry unit and feed it back to the pressure sensor communication module; The microfluidic chip is placed on the temperature control module and connected to the pressure sensor and pH sensor module through a Teflon tube to carry out the mixing operation of the reaction solution; The pH sensor module is connected to the microfluidic chip and the back pressure valve through a Teflon tube, and is electrically connected to the main control unit to measure the pH value of the product at the outlet of the microfluidic chip and transmit it back to the main control unit; The back pressure valve is connected to the pH sensor module through a Teflon tube to control the pressure of the reaction system in the flow chemistry unit.

[0008] The beneficial effects of the present invention are: (1) The present invention adopts FPGA and ARM heterogeneous underlying hardware architecture and does not rely on any operating system, which greatly enhances the timeliness and efficiency of task response and provides a solid guarantee for the reliability of complex flow chemistry experimental processes.

[0009] (2) The present invention adopts a high-precision two-phase four-wire stepper motor, a PT1000 temperature sensor and a pressure sensor, which can accurately control and measure reaction conditions such as temperature, pressure, pH, flow rate, etc. during the reaction process. The error range is small, which ensures the accuracy of the experimental results and greatly improves the quality of the experimental data and its scientific research value.

[0010] (3) The present invention provides two experimental modes: automatic response and manual response. Different operation modes can be selected according to user needs to adapt to different experimental scenarios and research purposes. During the operation of the system, multi-dimensional and comprehensive protection measures such as overcurrent, overvoltage, and overtemperature are provided, and effective intervention can be quickly carried out when abnormal situations occur to ensure the safety of the system and the experiment. After the experiment, the system can also perform self-cleaning to avoid cross contamination, effectively improving the service life of the equipment and the continuity of the experiment.

[0011] (4) The design of the present invention is based on a high degree of compatibility and modularity. Different syringes and reaction modules can be easily replaced according to the reaction type, and can be adapted to a variety of chemical reagents and reaction systems. The system reserves an expansion interface to facilitate further upgrading of system functions in the future.

[0012] (5) The present invention has a high degree of automation and safety. The data and videos of the reaction process can be automatically saved locally, reducing the need for direct monitoring by experimental personnel. The experimental conditions are highly consistent and have good repeatability, providing a stable and reliable experimental platform for chemical research and teaching. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] Figure 1 This is a schematic diagram of the present invention; Figure 2 It is the overall workflow diagram of the present invention; Figure 3 The figure is a work flow chart of the present invention for performing a "traffic light reaction" experiment in manual mode.

[0014] In the figure, 1-DC constant voltage power supply; 2-PC; 3-main control board; 4-electricity metering module; 5-temperature control module; 6-solenoid valve; 7-stepping motor; 8-flow chemistry unit; 9-image sensor; 31-DC-DC voltage conversion module; 32-Ethernet interface; 33-main control unit; 34-configuration module; 35-electricity measurement communication module; 36-heating plate drive module; 37-ADC module; 38-pressure sensor communication module; 39-valve control module; 310-motor drive module; 331-FPGA chip; 332-ARM chip; 341-JTAG interface; 342-Flash; 343-EEPROM; 51-PTC heating plate; 52-PT1000 temperature sensor; 81-syringe pump; 82-pressure sensor; 83-microfluidic chip; 84-pH sensor module; 85-back pressure valve. DETAILED DESCRIPTION

[0015] The present invention is described in detail below with reference to the accompanying drawings and embodiments.

[0016] See also Figure 1 , this embodiment includes a DC constant voltage power supply 1, a PC 2, a main control board 3, an electric energy metering module 4, a temperature control module 5, a solenoid valve 6, a stepping motor 7, a flow chemistry unit 8 and an image sensor 9; The DC constant voltage power supply 1 is connected to the main control board 3 and the electric energy metering module 4, and directly or indirectly provides the power required for normal operation of each submodule; The PC 2 is connected to the main control board 3 and the image sensor 9, and serves as a host computer to realize interactive operations with the user. The PC 2 is configured with a front-end webpage operation page and a back-end database, sends control instructions to the main control board 3 via Gigabit Ethernet and receives the status information and data returned by the main control board 3, and obtains the image information collected by the image sensor 9 through the USB interface and displays and stores it; The main control board 3 is connected to the DC constant voltage power supply 1, the PC 2, the power metering module 4, the temperature control module 5, the solenoid valve 6, the stepper motor 7 and the flow chemical unit 8, and is used to receive and analyze the control instructions issued by the PC 2, drive the power metering module 4, the temperature control module 5, the solenoid valve 6, the stepper motor 7 and the flow chemical unit 8 to operate according to the instructions, thereby controlling the reaction conditions and process, and sending the collected data information to the PC 2 in a format required by the custom communication protocol; The electric energy metering module 4 is connected to the DC constant voltage power supply 1 and the main control board 3, is powered by the DC constant voltage power supply 1, receives instructions from the main control board 3, dynamically monitors the total current and total voltage, and transmits the current and voltage data back to the main control board 3 for processing; The temperature control module 5 is connected to the main control board 3 and is closely attached to the back of the microfluidic chip in the flow chemistry unit 8, so as to receive parameter setting and data reading instructions from the main control board 3, heat the microfluidic chip in the flow chemistry unit 8 to the target temperature at a set heating speed and then maintain the temperature. The temperature data in the experiment process is sampled and transmitted back to the main control board 3 in real time, so as to realize the temperature control of the flow chemistry unit 8 and meet the flow chemistry reaction under different temperature conditions; The solenoid valve 6 is connected to the main control board 3 and the flow chemical unit 8, and is used to receive channel setting and switching instructions from the main control board 3, and control the switching of reactants, cleaning agents and products between different flow chemical reaction channels; The stepper motor 7 is connected to the main control board 3 and the flow chemical unit 8, and is used to receive the motor parameter settings and driving instructions from the main control board 3, and feed back the motor parameter data to the main control board 3 in real time, and control the precise absorption and injection of the reactants and cleaning agents in the flow chemical unit 8 through the direction, speed, and moving distance of the two-phase four-wire stepper motor; The flow chemistry unit 8 is connected to the main control board 3, the temperature control module 5, the solenoid valve 6 and the stepper motor 7. The internal parts of the flow chemistry unit 8 are connected by Teflon tubes to form a reaction path of the flow chemistry reaction. At the same time, the main control board 3, the temperature control module 5, the solenoid valve 6 and the stepper motor 7 are electrically connected to exchange instructions and data, so that experiments can be carried out according to the reaction process according to the control instructions.

[0017] The image sensor 9 is connected to the PC 2 and is used to collect real-time images of the reaction process and transmit them to the PC 2 in the form of video for display and storage; wherein: The main control board 3 includes a DC-DC voltage conversion module 31, an Ethernet interface 32, a main control unit 33, a configuration module 34, an electric energy measurement communication module 35, a heating plate drive module 36, an ADC module 37, a pressure sensor communication module 38, a valve control module 39, and a motor drive module 310; The DC-DC voltage conversion module 31 is connected to the DC constant voltage power supply 1, the heating plate driving module 36, the motor driving module 310, the electric energy metering module 4 and the flow chemical unit 8, and is used to convert the 24V voltage output by the DC constant voltage power supply 1 into a 12V voltage for the heating plate driving module 36, the motor driving module 310, the electric energy metering module 4 and the pressure sensor in the flow chemical unit 8 to work normally; The Ethernet interface 32 is connected to the PC 2 and the main control unit 33, and serves as a physical carrier for communication between the PC 2 and the main control unit 33, and is used to send control instruction information of the PC 2 and upload data and status information collected by the main control unit 33; The main control unit 33 includes an FPGA chip 331 and an ARM chip 332, which are connected to the Ethernet interface 32, the configuration module 34, the power measurement communication module 35, the heating plate drive module 36, the ADC module 37, the pressure sensor communication module 38, the valve control module 39, the motor drive module 310 and the flow chemistry unit 8. The FPGA chip 331 adopts the XC7A35TFGG484-2 of Xilinx Company, which is responsible for the parsing, encapsulation and sending and receiving of UDP data packets, and is used to manage the two-way data communication between the Ethernet interface 32 and the ARM chip 332, and can store the startup mode and configuration information to the configuration module 34; the ARM chip 332 adopts the STM32H743XIH6 of ST Company, which is used to parse the control instructions transmitted by the FPGA chip 331, and realize the power measurement communication module 35, the heating plate drive module 36, the ADC module 37, the pressure sensor communication module 38, the valve control module 39, the motor drive module 310 and the flow chemistry unit 8. 8. Initialization and regulation of the valve control module 39 and the motor drive module 310, returning the collected current, voltage, temperature, pressure, motor parameter data and product pH data collected in the flow chemistry unit 8 to the FPGA chip 331. The motor parameter information after abnormal power failure will be stored in the configuration module 34 for restoring the motor position after power-on; after normal startup, the FPGA chip 331 continuously monitors the UDP data packet from the Ethernet interface 32. Once the packet header that conforms to the custom communication protocol is identified, the instruction information is extracted and passed to the ARM chip 332. The ARM chip 332 parses the instruction content according to the custom communication protocol, drives the corresponding module to run according to the instruction, and collects the required data and packages it in the data format specified by the custom communication protocol and sends it to the FPGA chip 331. The FPGA chip 331 encapsulates the data replied by the ARM chip 332 into a UDP data packet and sends it to the Ethernet interface 32; The configuration module 34 includes a JTAG interface 341, a Flash 342 and an EEPROM 343, and is connected to the main control unit 33 to select a startup mode, a curing program and store configuration parameters; The electric energy measurement communication module 35 is connected to the main control unit 33 and the electric energy metering module 4, communicates with the electric energy metering module 4 through the RS485 bus, collects the total voltage and total current in real time, and transmits them to the main control unit 33 for processing; The heating plate driving module 36 is connected to the DC-DC voltage conversion module 31, the main control unit 33 and the temperature control module 5, and is used to perform level conversion and drive capability enhancement on the PWM wave output by the ARM chip pin in the main control unit 33, thereby controlling the heating plate in the temperature control module 5 to heat according to the set temperature and speed to achieve the reaction temperature condition; The ADC module 37 is connected to the main control unit 33 and the temperature control module 5, converts the resistance change of the temperature sensor in the temperature control module 5 into a voltage change, and conditions the voltage signal so that the ARM chip in the main control unit 33 can correctly collect the current reaction temperature data; The pressure sensor communication module 38 is connected to the main control unit 33 and the flow chemistry unit 8, and communicates with the actual pressure sensor in the flow chemistry unit 8 through the RS485 bus, collects the pressure data of the current reaction in real time, and transmits it to the main control unit 33 for processing; The valve control module 39 is connected to the DC constant voltage power supply 1, the main control unit 33 and the solenoid valve 6 to control the on and off of different channels of the solenoid valve; The motor drive module 310 is connected to the DC-DC voltage conversion module 31, the main control unit 33 and the stepper motor 7, performs level conversion and driving capability enhancement on the control signal output by the ARM chip pin in the main control unit 33, and realizes precise control of the running direction, speed and number of steps of the stepper motor 7 through the subdivision drive of the motor drive chip.

[0018] See also Figure 1 , the temperature control module 5 includes a PTC heating plate 51 and a PT1000 temperature sensor 52; The PTC heating plate 51 is connected to the heating plate driving module 36 and the flow chemical unit 8 to heat the reaction system in the flow chemical unit 8 to the target temperature at a set speed; The PT1000 temperature sensor 52 is connected to the ADC module 37 and the flow chemical unit 8 to control the temperature of the reaction system in the flow chemical unit 8 so that the reaction can be carried out at any temperature within the range of 25-200°C.

[0019] See also Figure 1 , the flow chemistry unit 8 includes a syringe pump 81, a pressure sensor 82, a microfluidic chip 83, a pH sensor module 84 and a back pressure valve 85; The injection pump 81 is connected to the pressure sensor 82 through a Teflon tube, and is electrically connected to the electromagnetic valve 6 and the stepper motor 7. Through the switching of the electromagnetic valve 6 and the forward and reverse rotation of the stepper motor 7, the reaction solution or the cleaning reagent can be sucked and injected to deliver the liquid to the chemical reaction passage. The pressure sensor 82 is connected to the syringe pump 81 and the microfluidic chip 83 through a Teflon tube, and is electrically connected to the DC-DC voltage conversion module 31 and the pressure sensor communication module 38, so as to monitor the real-time pressure in the flow chemistry unit 8 and feed back to the pressure sensor communication module 38; The microfluidic chip 83 is placed on the temperature control module 5 and connected to the pressure sensor 82 and the pH sensor module 84 through a Teflon tube to carry out the mixing operation of the reaction solution; The pH sensor module 84 is connected to the microfluidic chip 83 and the back pressure valve 85 through a Teflon tube, and is electrically connected to the main control unit 33 to measure the pH value of the product at the outlet of the microfluidic chip 83 and transmit it back to the main control unit 33; The back pressure valve 85 is connected to the pH sensor module 84 via a Teflon tube to control the pressure of the reaction system in the flow chemistry unit 8 .

[0020] See also Figure 2 , after the present invention starts working, the experimenter needs to log in to the web-side experimental platform operation interface on the PC, and the experimenter's operations are based on this interface. First, click the initialization button, the system will perform a self-check, if each module functions normally, the initialization is completed; if not, the experimenter is reminded to perform a power-off check. After the system is successfully initialized, the experimenter can choose whether to use manual mode or automatic mode for this experiment. If the automatic mode is selected, after the experiment is started, the PC background will automatically load the Excel file with the preset instructions, the main control board will parse the preset instructions one by one, control the temperature control module, solenoid valve, stepper motor and other modules to work, and automatically control the experimental process in the flow chemistry unit according to the reaction process. During this process, the experimenter can click the video recording button, and the image sensor will start recording the experimental video and transmit it to the PC interface in real time for display. If the manual mode is selected, after starting the experiment, the experimenter can set the target temperature, heating rate and alarm threshold of the heating plate, as well as the alarm threshold of the pressure sensor on the PC operation interface, and then click the video recording button. The image sensor starts recording the experimental video and transmits it to the PC interface in real time for display. During the experiment, the experimenter needs to manually adjust the parameters of the solenoid valve and stepper motor on the PC operation interface according to the different stages of the reaction process, so as to control the experimental process in the flow chemistry unit and ensure the normal progress of the experiment. During the experiment, the main control board will monitor in real time whether each reaction condition is within the preset range through the power metering module, temperature sensor, pressure sensor, pH sensor and other modules. Once a reaction condition exceeds the range, the heating plate, solenoid valve, and stepper motor will stop working immediately, and the reaction in the fluid chemistry unit will stop. The main control board will report an error to the PC, and the operation interface will display an alarm pop-up window to remind the experimenter to power off and check. If the reaction conditions are always within the preset range, when the experiment is over, the image sensor will end video recording, and the experimental video will be saved locally on the PC for subsequent playback and viewing; the data information collected by the main control board will be uploaded to the PC for summary, and the generated experimental report will also be saved locally; the main control board will then control the injection pump to absorb the cleaning reagent, automatically clean the equipment in the flow chemistry unit, and prepare for the next experiment.

[0021] See also Figure 3 , take the "traffic light reaction" experiment in manual mode as an example. The experimenter is required to log in to the web-based experimental platform operation interface on the PC, and the experimenter's operations are based on this interface. First, click the initialization button, the system will perform a self-check. If each module functions normally, the initialization is completed; if not, the experimenter is reminded to perform a power outage check. After the system is initialized successfully, the experimenter selects manual mode for this experiment. After starting the experiment, the experimenter first adjusts the back pressure valve to 80kPa, sets the pressure alarm threshold to 90kPa on the PC operation interface, the heating plate target temperature to 40°C, the heating rate to medium speed, and the temperature alarm threshold to 60°C. Next, set the first solenoid valve to select the first channel, the syringe volume of the first injection pump is 20 mL, and the suction operation is performed to absorb 5 mL of alkaline glucose solution at a flow rate of 5 mL / min; set the second solenoid valve to select the first channel, the syringe volume of the second injection pump is 20 mL, and the suction operation is performed to absorb 5 mL of sodium indigo disulfonate solution at a flow rate of 5 mL / min, and then click the video recording button, the image sensor starts recording the experimental video, and displays it in real time on the PC interface. When both injection pumps have finished absorbing the reaction reagents and the temperature of the heating plate has reached 40°C, the experimenter sets the first solenoid valve on the PC operation interface to select the third channel, the syringe volume of the first injection pump is 20mL, and the injection operation is performed to inject 5mL of alkaline glucose solution into the microfluidic chip at a flow rate of 0.5mL / min for reaction; the second solenoid valve is set to select the third channel, the syringe volume of the second injection pump is 20mL, and the injection operation is performed to inject 5mL of sodium indigo disulfonate solution into the microfluidic chip at a flow rate of 0.5mL / min for reaction. During the experiment, it can be observed that the solution in the microfluidic chip will produce a green-red-yellow color change phenomenon with time and space changes. During the experiment, the main control board will monitor in real time whether each reaction condition is within the preset range through power metering modules, temperature sensors, pressure sensors, pH sensors and other modules. Once a reaction condition exceeds the range, the heating plate, solenoid valve, and stepper motor will stop working immediately, and the reaction in the fluid chemistry unit will stop. The main control board will report the error to the PC, and the operation interface will display an alarm pop-up window to remind the experimenter to turn off the power for troubleshooting. If the reaction conditions are always within the preset range, when the experiment is over, the image sensor will end the video recording, and the experimental video will be saved locally on the PC for subsequent playback and viewing; the data information collected by the main control board will be uploaded to the PC for summary, and the generated experimental report will also be saved locally; then the main control board will control the injection pump to absorb the cleaning reagent, automatically clean the equipment in the flow chemistry unit, and prepare for the next experiment.

[0022] The above is only a further explanation of the present invention, and is not intended to limit the present invention. Any equivalent implementation of the present invention should be included in the scope of the claims of the present invention. For those of ordinary skill in the art, equivalent replacement or change can be made according to the technical solution and inventive concept of the present invention, and all these changes or replacements should belong to the protection scope of the claims attached to the present invention.

Claims

1. A flow chemistry intelligent experimental platform, characterized in that: The platform includes a DC constant voltage power supply (1), a PC (2), a main control board (3), an electric energy metering module (4), a temperature control module (5), a solenoid valve (6), a stepper motor (7), a flow chemistry unit (8) and an image sensor (9); The DC constant voltage power supply (1) is connected to the main control board (3) and the electric energy metering module (4) to directly or indirectly provide power required for normal operation; The PC (2) is connected to the main control board (3) and the image sensor (9), and serves as a host computer to implement interactive operations with the user. The PC (2) is configured with a front-end webpage operation page and a back-end database, and sends control instructions to the main control board (3) via Gigabit Ethernet and receives status information and data returned by the main control board (3). The PC (2) obtains image information collected by the image sensor (9) via a USB interface and displays and stores the information; The main control board (3) is connected to the DC constant voltage power supply (1), the PC (2), the electric energy metering module (4), the temperature control module (5), the solenoid valve (6), the stepper motor (7) and the flow chemical unit (8) to receive and analyze control instructions issued by the PC (2), drive the electric energy metering module (4), the temperature control module (5), the solenoid valve (6), the stepper motor (7) and the flow chemical unit (8) to operate according to the instructions, thereby controlling the reaction conditions and process, and sending the collected data information to the PC (2) in a package format required by the custom communication protocol; The electric energy metering module (4) is connected to the DC constant voltage power supply (1) and the main control board (3), is powered by the DC constant voltage power supply (1), receives instructions from the main control board (3), dynamically monitors the total current and the total voltage, and transmits the current and voltage data back to the main control board (3) for processing; The temperature control module (5) is connected to the main control board (3) and is closely attached to the back of the microfluidic chip in the flow chemistry unit (8), and is used to receive parameter setting and data reading instructions transmitted by the main control board (3), heat the microfluidic chip in the flow chemistry unit (8) to a target temperature at a set heating speed, and then maintain the temperature. The temperature data during the experiment is sampled and transmitted back to the main control board (3) in real time, so as to realize temperature control of the flow chemistry unit (8) and meet the flow chemistry reaction conditions under different temperature conditions; The solenoid valve (6) is connected to the main control board (3) and the flow chemical unit (8) to receive channel setting and switching instructions from the main control board (3) and control the switching of reactants, cleaning agents and products between different flow chemical reaction channels; The stepper motor (7) is connected to the main control board (3) and the flow chemical unit (8) to receive the motor parameter settings and drive instructions from the main control board (3), and to feed back the motor parameter data to the main control board (3) in real time, thereby controlling the precise absorption and injection of reactants and cleaning agents in the flow chemical unit (8) through the direction, speed, and moving distance of the two-phase four-wire stepper motor; The flow chemical unit (8) is connected to the main control board (3), the temperature control module (5), the solenoid valve (6) and the stepping motor (7); the internal parts of the flow chemical unit (8) are connected by Teflon tubes, and together form a reaction path of the flow chemical reaction; at the same time, the main control board (3), the temperature control module (5), the solenoid valve (6) and the stepping motor (7) are electrically connected to exchange instructions and data, so that the experiment can be carried out according to the control instructions and the reaction process; The image sensor (9) is connected to the PC (2) and is used to collect real-time images of the reaction process and transmit them to the PC (2) in the form of video for display and storage; wherein: The main control board (3) comprises a DC-DC voltage conversion module (31), an Ethernet interface (32), a main control unit (33), a configuration module (34), an electric energy measurement communication module (35), a heating plate drive module (36), an ADC module (37), a pressure sensor communication module (38), a valve control module (39), and a motor drive module (310); The DC-DC voltage conversion module (31) is connected to the DC constant voltage power supply (1), the heating plate driving module (36), the motor driving module (310), the electric energy metering module (4) and the flow chemical unit (8) to convert the 24V voltage output by the DC constant voltage power supply (1) into a 12V voltage for normal operation of the heating plate driving module (36), the motor driving module (310), the electric energy metering module (4) and the pressure sensor in the flow chemical unit (8); The Ethernet interface (32) is connected to the PC (2) and the main control unit (33) and serves as a physical carrier for communication between the PC (2) and the main control unit (33), and is used to send control instructions from the PC (2) and upload data and status information collected by the main control unit (33); The main control unit (33) comprises an FPGA chip (331) and an ARM chip (332), and is connected to the Ethernet interface (32), the configuration module (34), the electric energy measurement communication module (35), the heating plate drive module (36), the ADC module (37), the pressure sensor communication module (38), the valve control module (39), the motor drive module (310) and the flow chemistry unit (8). The FPGA chip (331) is responsible for parsing, encapsulating and sending and receiving UDP data packets, and is used to manage the two-way data communication between the Ethernet interface (32) and the ARM chip (332), and can store the startup mode and configuration information in the configuration module (34); the ARM chip (332) is used to parse the control instructions transmitted by the FPGA chip (331), and realize the electric energy measurement communication module (35), the heating plate drive module (36), the ADC module (37), the pressure sensor communication module (38), the valve control module (39) and the motor drive module (310). The module (310) is initialized and regulated, and the collected current, voltage, temperature, pressure, motor parameter data and product pH data collected in the flow chemistry unit (8) are returned to the FPGA chip (331). The motor parameter information after abnormal power failure is stored in the configuration module (34) for restoring the motor position after power-on. After normal startup, the FPGA chip (331) continuously monitors the UDP data packet from the Ethernet interface (32). Once a packet header that conforms to the custom communication protocol is identified, the instruction information is extracted and transmitted to the ARM chip (332). The ARM chip (332) parses the instruction content according to the custom communication protocol, drives the corresponding module to run according to the instruction, collects the required data, packages it in the data format specified by the custom communication protocol, and sends it to the FPGA chip (331). The FPGA chip (331) encapsulates the data replied by the ARM chip (332) into a UDP data packet and sends it to the Ethernet interface (32). The configuration module (34) includes a JTAG interface (341), a Flash (342) and an EEPROM (343), and is connected to the main control unit (33) to select a startup mode, a curing program and store configuration parameters; The electric energy measurement communication module (35) is connected to the main control unit (33) and the electric energy metering module (4), communicates with the electric energy metering module (4) via an RS485 bus, collects total voltage and total current in real time, and transmits them to the main control unit (33) for processing; The heating plate driving module (36) is connected to the DC-DC voltage conversion module (31), the main control unit (33) and the temperature control module (5) to perform level conversion and enhance the driving capability of the PWM wave output by the ARM chip pin in the main control unit (33), thereby controlling the heating plate in the temperature control module (5) to heat according to the set temperature and speed to achieve the reaction temperature condition; The ADC module (37) is connected to the main control unit (33) and the temperature control module (5), converts the resistance change of the temperature sensor in the temperature control module (5) into a voltage change, and conditions the voltage signal so that the ARM chip in the main control unit (33) can correctly collect the current reaction temperature data; The pressure sensor communication module (38) is connected to the main control unit (33) and the flow chemistry unit (8), communicates with the pressure sensor in the flow chemistry unit (8) via the RS485 bus, collects pressure data of the current reaction in real time, and transmits it to the main control unit (33) for processing; The valve control module (39) is connected to the DC constant voltage power supply (1), the main control unit (33) and the solenoid valve (6) to control the on and off of different channels of the solenoid valve; The motor drive module (310) is connected to the DC-DC voltage conversion module (31), the main control unit (33) and the stepper motor (7), performs level conversion and driving capability enhancement on the control signal output by the ARM chip pin in the main control unit (33), and achieves precise control of the running direction, speed and number of steps of the stepper motor (7) through the subdivision drive of the motor drive chip.

2. The flow chemistry intelligent experimental platform according to claim 1, characterized in that: The temperature control module (5) comprises a PTC heating plate (51) and a PT1000 temperature sensor (52); The PTC heating plate (51) is connected to the heating plate driving module (36) and the flow chemistry unit (8) to heat the reaction system in the flow chemistry unit (8) to a target temperature at a set speed; The PT1000 temperature sensor (52) is connected to the ADC module (37) and the flow chemistry unit (8) to control the temperature of the reaction system in the flow chemistry unit (8) so that the reaction can be carried out at any temperature within the range of 25 to 200°C.

3. The flow chemistry intelligent experimental platform according to claim 1, characterized in that: The flow chemistry unit (8) comprises a syringe pump (81), a pressure sensor (82), a microfluidic chip (83), a pH sensor module (84) and a back pressure valve (85); The injection pump (81) is connected to the pressure sensor (82) via a Teflon tube, and is electrically connected to the electromagnetic valve (6) and the stepper motor (7). By switching the electromagnetic valve (6) and rotating the stepper motor (7) forward and reverse, the injection pump (81) can absorb and inject the reaction solution or the cleaning reagent to deliver the liquid to the chemical reaction passage. The pressure sensor (82) is connected to the injection pump (81) and the microfluidic chip (83) via a Teflon tube, and is electrically connected to the DC-DC voltage conversion module (31) and the pressure sensor communication module (38) to monitor the real-time pressure in the flow chemistry unit (8) and feed back to the pressure sensor communication module (38); The microfluidic chip (83) is placed on the temperature control module (5) and connected to the pressure sensor (82) and the pH sensor module (84) via a Teflon tube to carry out the mixing operation of the reaction solution; The pH sensor module (84) is connected to the microfluidic chip (83) and the back pressure valve (85) via a Teflon tube, and is electrically connected to the main control unit (33) to measure the pH value of the product at the outlet of the microfluidic chip (83) and transmit it back to the main control unit (33); The back pressure valve (85) is connected to the pH sensor module (84) via a Teflon tube to control the pressure of the reaction system in the flow chemistry unit (8).

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