Traditional Chinese medicine composition for treating prostatic hyperplasia and preparation method and application thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating prostatic hyperplasia and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition provided by the invention comprises the following active ingredients in parts by weight: 10-18 parts of centipede, 20-30 parts of earthworm, 25-35 parts of lycopene, 15-25 parts of cicada slough, 10-18 parts of poria cocos and 1-3 parts of dog penis, and is used for treating prostatic hyperplasia. The traditional Chinese medicine composition provided by the invention only has six effective components, is reasonable in compatibility and simple in composition, does not have drug interaction risk and allergy risk possibly caused by complex medication, and can improve the symptom of prostatic hyperplasia and regulate the overall physical condition of a patient through the effects of dredging collaterals and removing stasis, reducing fever and causing diuresis, tonifying kidney and strengthening yang and the like; the traditional Chinese medicine composition has a remarkable improvement effect on prostatic hyperplasia.

Description

Technical Field

[0001] The invention belongs to the technical field of Chinese medicine compositions, and in particular relates to a Chinese medicine composition for treating prostatic hypertrophy, and a preparation method and application thereof. Background Art

[0002] Prostatic hyperplasia, commonly known as prostate enlargement, is one of the common diseases in middle-aged and elderly men. Common symptoms include urinary tract obstruction, frequent urination, and urgency. In severe cases, it can affect the patient's quality of life. Clinical treatment methods for this disease mainly include Western medicine treatment, minimally invasive treatment, and surgical treatment. However, the listed Western medicines have certain defects in tolerance and some side effects. For example, tamsulosin may cause retrograde ejaculation, finasteride may cause male breast hypertrophy, and sildenafil may cause visual impairment. Minimally invasive treatment and surgical treatment not only have a high recurrence rate, but also cause erectile dysfunction in patients. Therefore, it is necessary to provide a drug that is safer and more effective for patients to treat prostatic hypertrophy. At present, there are some important compositions for treating prostatic hypertrophy. For example, the Chinese invention patent with application number 201711081802.X discloses a traditional Chinese medicine composition for treating prostate diseases, which is composed of the following raw materials: oyster, safflower, fenugreek, chuanlianzi, winter mellitus, two-headed sharp sword, centipede, mole cricket, earthworm, pyrrosia, radix polygoni multiflori, desmodium, tuckahoe, lobelia, honeysuckle, kelp, seaweed, trillium, atractylodes, antler slices, soapberry, nail bead, borneol, divaricate wood, licorice, white snake grass and leech. Or, for example, the Chinese invention patent with application number 201010544956.X discloses a drug for rapid treatment of prostatic hyperplasia, which is composed of the following raw materials: plantain, cricket, mole cricket, cicada slough, phellodendron, sophora flavescens, rhizoma anemarrhenae, astragalus, placenta, dragonfly, aconitifolia, silkworm excrement, rosa canina, cynomorium songaricum, psoralea corylifolia, velvet antler, wolfberry, cistanche deserticola, astragalus, gecko, mulberry, polygonum multiflorum, antelope horn, prepared rehmannia root, radish seed, turtle shell, grub, motherwort, tongcao, ternate, zedoaria, actinolite and cyathula. However, the composition of this type of Chinese medicine composition is complex, and patients need to consider many medication and dietary taboos after taking it, and more raw materials increase the probability of allergies or liver and kidney toxicity, resulting in reduced medication safety. Summary of the invention

[0003] The technical problem to be solved by the present invention is to provide a Chinese medicine composition for treating prostatic hypertrophy with high medication safety and significant therapeutic effect, as well as a preparation method and application thereof.

[0004] In order to solve the above technical problems, the technical solution adopted by the present invention is: a traditional Chinese medicine composition for treating prostatic hypertrophy, wherein the effective ingredients include 10-18 parts of centipedes, 20-30 parts of earthworms, 25-35 parts of lycopene, 15-25 parts of cicada shells, 10-18 parts of Poria cocos and 1-3 parts of dog whip, by weight.

[0005] Another technical solution adopted by the present invention is: use of the above-mentioned traditional Chinese medicine composition in the preparation of a medicine for treating prostatic hypertrophy.

[0006] Another technical solution adopted by the present invention is: a method for preparing a Chinese medicine composition for treating prostatic hypertrophy, comprising the following steps: S1. Crush centipedes, earthworms, cicada shells, Poria cocos and dog whips respectively; S2. Mix 10-18 parts of centipedes, 20-30 parts of earthworms, 25-35 parts of lycopene, 15-25 parts of cicada shells, 10-18 parts of Poria cocos and 1-3 parts of dog whip by weight to obtain a mixture; S3. Sterilize the mixture to obtain a Chinese medicinal composition for treating prostatic hypertrophy.

[0007] The beneficial effects of the present invention are as follows: the Chinese medicine composition provided by the present invention has only six active ingredients, the compatibility is reasonable and the composition is simple, there is no risk of drug interaction and allergy that may be caused by complex medication, and at the same time, through the effects of dredging meridians and resolving nodules, clearing away heat and promoting diuresis, tonifying the kidney and strengthening yang, etc., it can improve the symptoms of prostatic hypertrophy and regulate the patient's overall physical condition, and has a significant improvement effect on prostatic hypertrophy. BRIEF DESCRIPTION OF THE DRAWINGS

[0008] Figure 1 This is a B-ultrasound image of a patient before medication in an example of a specific embodiment of the present invention; Figure 2 This is an ultrasound image of a patient after medication in an example in a specific implementation manner of the present invention. DETAILED DESCRIPTION

[0009] In order to explain the technical content, achieved objectives and effects of the present invention in detail, the following is an explanation in combination with the implementation modes and the accompanying drawings.

[0010] A Chinese medicine composition for treating prostatic hypertrophy comprises, by weight, effective ingredients including 10-18 parts of centipedes, 20-30 parts of earthworms, 25-35 parts of lycopene, 15-25 parts of cicada shells, 10-18 parts of tuckahoe and 1-3 parts of dog whip.

[0011] Among them, the centipede is roasted centipede, and the dog penis is made with wine.

[0012] From the above description, it can be seen that the beneficial effects of the present invention are: The Chinese medicine composition provided by the present invention has only six effective ingredients, namely, centipede (roasted), earthworm, lycopene, cicada slough, tuckahoe and dog whip (made with wine). Among them: Centipede (roasted) comes from the Scolopendra subspinipes Scolopendra subspinipes mutilatingThe dried form of L. Koch has the effects of calming wind and relieving spasms, dredge meridians and relieve pain, attacking toxins and dispersing knots. It is used for treating liver wind movement, spasms and convulsions, infantile convulsions, stroke, hemiplegia, tetanus, rheumatism, migraine, sores, scrofula, snake and insect bites. Using roasted centipedes can reduce toxicity and make them easier to store and use.

[0013] Pheretima sphaerocephala Pheretima aspergillus (E.Perrier), common earthworm Common sedge Chen, Pheretima Williamii William's Pheretima (Michaelsen) or Pheretima sphenanthera Pheretima pectinifera The dried form of Michaelsen has the effects of clearing away heat and calming convulsions, unblocking meridians, relieving asthma and promoting diuresis. It is used for high fever and coma, epilepsy and convulsions, joint pain, limb numbness, hemiplegia, lung heat, asthma and cough, edema and oliguria.

[0014] Lycopene is a carotene extracted from tomatoes, Solanum lycopersicum L. It is a very strong antioxidant with a strong ability to scavenge free radicals. It has the effects of preventing cardiovascular and cerebrovascular diseases, improving immunity, and delaying aging.

[0015] Cicada molts into black grasshopper Cryptotympana pustulata The skin that Fabricius nymphs shed when they emerge from their pupae; it has the effects of dispersing wind-heat, relieving sore throat, clearing rashes, improving eyesight and removing cataracts, and relieving spasms. It is used for wind-heat colds, sore throats and hoarseness, measles that do not break out, itchy rubella, red eyes and cataracts, convulsions, and tetanus.

[0016] Poria cocos Poria cocos (Schw.) The dried sclerotium of Wolf has the effects of promoting diuresis and eliminating dampness, strengthening the spleen and calming the mind. It is used for edema, oliguria, phlegm and fluid, dizziness and palpitations, spleen deficiency, poor appetite, loose stools and diarrhea, restlessness, palpitations and insomnia.

[0017] Dog whip (wine-made) is a kind of canine animal Family dog Linnaeus's dried penis and testicles are processed; they have the effects of warming the kidney and strengthening yang, replenishing essence and filling the marrow, and are used for kidney yang deficiency, impotence and spermatorrhea, weakness of the waist and knees, and leucorrhea in women. Using wine to make dog whip can reduce the fishy smell of dog whip, and at the same time make it more crispy and increase the content of extract, thereby improving the efficacy.

[0018] The present invention utilizes the above six Chinese medicines for reasonable compatibility. Centipede can relieve pain, attack toxins and dissipate stagnation, earthworm can relieve stagnation and promote diuresis, and they are all monarch medicines; cicada slough can clear away heat and dampness, tomato can nourish yin and cool blood, and its lycopene has the effects of anti-oxidation and anti-inflammatory, and they are all minister medicines; Poria can promote diuresis and eliminate dampness, and is an adjuvant; dog whip can warm the kidney and strengthen yang, and replenish essence and benefit marrow, and is a guiding medicine. The six Chinese medicines are irreplaceable and indispensable. The six flavors of the whole prescription can play the role of dredging collaterals and dispersing stagnation, clearing away heat and dampness, replenishing the kidney and benefiting essence, so that the bladder is gasified and the urination is self-benefiting, and together constitute a compound preparation that not only pays attention to traditional Chinese medicine theory but also takes into account modern pharmacological research, thereby achieving the effect of improving the symptoms of prostatic hypertrophy and regulating the overall physical condition of the patient.

[0019] Furthermore, the active ingredients include 12-16 parts of centipede, 22-26 parts of earthworm, 28-32 parts of lycopene, 18-22 parts of cicada shell, 12-16 parts of Poria cocos and 1.5-2.5 parts of dog whip, by weight. Furthermore, by weight, the effective ingredients include 14 parts of centipedes, 25 parts of earthworms, 30 parts of lycopene, 20 parts of cicada shells, 14 parts of Poria cocos and 2 parts of dog whip.

[0020] Furthermore, the dosage form of the Chinese medicine composition is powder, tablet, pill, capsule or granule-type granule.

[0021] Furthermore, the above-mentioned Chinese medicine composition is applied to the preparation of a drug for treating prostatic hypertrophy.

[0022] From the above description, it can be seen that the effective ingredients are centipede (roasted), earthworm, lycopene, cicada molt, poria and dog whip (made with wine). Other auxiliary materials can also be added according to the required dosage form to prepare different types of drugs for treating prostatic hypertrophy.

[0023] Furthermore, a method for preparing a Chinese medicine composition for treating prostatic hypertrophy comprises the following steps: S1. Crush centipedes, earthworms, cicada shells, Poria cocos and dog whips respectively; S2. Mix 10-18 parts of centipedes, 20-30 parts of earthworms, 25-35 parts of lycopene, 15-25 parts of cicada shells, 10-18 parts of Poria cocos and 1-3 parts of dog whip by weight to obtain a mixture; S3. Sterilize the mixture to obtain a Chinese medicinal composition for treating prostatic hypertrophy.

[0024] Furthermore, after the pulverization in S1, the product is sieved through a 80-100 mesh sieve.

[0025] Furthermore, the sterilization in S3 is high-temperature instantaneous sterilization.

[0026] Furthermore, the temperature of high temperature instantaneous sterilization is 140~180℃ and the time is 5~20s.

[0027] From the above description, it can be seen that a method for preparing a powder is provided, which can effectively retain the active ingredients while ensuring the safety and stability of the product.

[0028] Furthermore, a method for preparing a pill for treating prostatic hypertrophy comprises the following steps: S1. Crush centipedes, earthworms, cicada shells, tuckahoe and dog whips respectively and pass through 80-100 mesh sieves; S2. Mix 10-18 parts of centipedes, 20-30 parts of earthworms, 25-35 parts of lycopene, 15-25 parts of cicada shells, 10-18 parts of Poria cocos and 1-3 parts of dog whip by weight to obtain a mixture; S3, sterilizing the mixture to obtain a Chinese medicinal composition for treating prostatic hypertrophy; S4, the Chinese medicine composition is soaked in water to make pills, a soft material is prepared, and then the pills are made, the pills are trimmed, dried, and finally coated to obtain pills.

[0029] Embodiment 1 of the present invention is: A method for preparing a Chinese medicine composition for treating prostatic hypertrophy comprises the following steps: S1. Crush centipedes (roasted), earthworms, cicada shells, tuckahoe and dog whip (made with wine) separately through an 80-mesh sieve; S2, by weight, 14 parts of centipedes, 25 parts of earthworms, 30 parts of lycopene, 20 parts of cicada shells, 14 parts of Poria cocos and 2 parts of dog whips were mixed to obtain a mixture; S3. The mixture is sterilized instantaneously at high temperature (160° C., 12 seconds) to obtain a Chinese medicine composition for treating prostatic hypertrophy.

[0030] Embodiment 2 of the present invention is: A method for preparing a pill for treating prostatic hypertrophy comprises the following steps: The Chinese medicine composition obtained in S3 of Example 1 is made into pills with water, softened, and then made into pills. The pills are trimmed and dried, and each 18 pills weigh 3.1 g. Finally, the pills are coated to obtain pills.

[0031] Effectiveness test: 30 people (or their family members), male, aged 40-65 years old, were recruited in the company to take the Chinese medicine pills of Example 2 alone (no other drugs or health products were taken during the period of taking them) for 2 courses of treatment (2 months), twice a day, 3.1g (18 pills) each time, and prostate B-ultrasound detection was performed before and after taking them. The overall effective rate reached 90%, and the results are shown in Table 1. Among them, no change means that there is basically no change within the normal error range of B-ultrasound detection, and it does not require the same measurement results.

[0032] Table 1

[0033] One of the patients, Zhou Mouyuan, male, 58 years old, had long-term urination difficulties, frequent urination, and incomplete urination. After examination by a doctor, he was diagnosed with uneven thickening of the intima-media membrane of bilateral carotid arteries with plaques on the right side, enlarged prostate and calcified plaques, with obvious characteristics of prostate hypertrophy. He took the pills of this product (Example 2) alone for 1 course of treatment (1 month), twice a day, 18 pills (3.1 g) each time. The physical examination reports of Zhangzhou Public Hospital before and after taking the medicine showed that the prostate was significantly smaller, from 37mm×43mm×41mm to 28mm×38mm×28mm. The B-ultrasound report photos before and after taking the medicine are shown in the table below. Figure 1 and Figure 2 shown.

[0034] Embodiment 3 of the present invention is: A method for preparing a Chinese medicine composition for treating prostatic hypertrophy comprises the following steps: S1. Crush centipede (roasted), earthworm, cicada shell, tuckahoe and dog whip (made with wine) separately and pass through a 100-mesh sieve; S2. Mix 10 parts of roasted centipede, 20 parts of earthworm, 25 parts of lycopene, 15 parts of cicada shell, 10 parts of Poria cocos and 1 part of dog whip (made with wine) by weight to obtain a mixture; S3. The mixture is sterilized instantaneously at high temperature (140° C., 20 s) to obtain a Chinese medicine composition for treating prostatic hypertrophy.

[0035] Embodiment 4 of the present invention is: A method for preparing a Chinese medicine composition for treating prostatic hypertrophy comprises the following steps: S1. Crush centipede (roasted), earthworm, cicada shell, tuckahoe and dog whip (made with wine) separately and pass through a 100-mesh sieve; S2, by weight, 18 parts of centipede (roasted), 30 parts of earthworm, 35 parts of lycopene, 25 parts of cicada shell, 18 parts of Poria cocos and 3 parts of dog whip (made with wine) were mixed to obtain a mixture; S3. The mixture is sterilized instantaneously at high temperature (180° C., 5 s) to obtain a Chinese medicine composition for treating prostatic hypertrophy.

[0036] Embodiment 5 of the present invention is: Calculated by weight, the effective ingredients include 12 parts of roasted centipede, 23 parts of earthworm, 27 parts of lycopene, 19 parts of cicada shell, 13 parts of Poria cocos and 2 parts of dog whip (made with wine).

[0037] Embodiment 6 of the present invention is: By weight, the effective ingredients include 16 parts of roasted centipede, 28 parts of earthworm, 31 parts of lycopene, 23 parts of cicada shell, 15 parts of Poria cocos and 2.5 parts of dog whip.

[0038] Embodiment 7 of the present invention is: Calculated by weight, the effective ingredients include 15 parts of roasted centipede, 29 parts of earthworm, 32 parts of lycopene, 24 parts of cicada shell, 17 parts of Poria cocos and 2.5 parts of dog whip (made with wine).

[0039] Embodiment 8 of the present invention is: Calculated by weight, the effective ingredients include 11 parts of roasted centipede, 21 parts of earthworm, 28 parts of lycopene, 20 parts of cicada shell, 11 parts of Poria cocos and 1 part of dog whip (made with wine).

[0040] Embodiment 9 of the present invention is: Calculated by weight, the effective ingredients include 17 parts of roasted centipede, 20-30 parts of earthworm, 33 parts of lycopene, 22 parts of cicada shell, 16 parts of Poria cocos and 2 parts of dog whip (made with wine).

[0041] Embodiment 10 of the present invention is: Calculated by weight, the effective ingredients include 14 parts of roasted centipede, 22 parts of earthworm, 30 parts of lycopene, 15-25 parts of cicada shell, 14 parts of Poria cocos and 1.5 parts of dog whip.

[0042] Comparative Example 1: Without adding lycopene, 14 parts of centipede, 25 parts of earthworm, 20 parts of cicada shell, 14 parts of Poria and 2 parts of dog whip (made with wine) were mixed by weight to obtain a mixture, which was made into pills and coated. After trial, it was shown that the symptoms of frequent urination and urgency were relieved relatively slowly, and the effect was delayed by 1 to 2 weeks compared with the Chinese medicine composition with lycopene added, and some users still had occasional nocturia after taking 2 courses of treatment, and the effect was poor.

[0043] Comparative Example 2: According to weight, 14 parts of centipede, 25 parts of earthworm, 30 parts of lycopene, 20 parts of cicada shell, 14 parts of Poria cocos and 2 parts of dog whip (not made of wine) are mixed to obtain a mixture, which is made into pills and coated. After trial, it is found that the fishy smell is very strong, it is impossible to swallow, and it will cause vomiting.

[0044] In summary, the effective ingredients of the Chinese medicine composition provided by the present invention only contain six Chinese medicines. These six Chinese medicines are reasonably matched and can effectively treat prostate hypertrophy without the need for a large number of other effective ingredients. They can also effectively relieve the symptoms of frequent urination and urgency, have higher medication safety, reduce the medication and dietary taboos that patients need to consider after taking the medicine, and greatly reduce the risk of allergies within the scope of reasonable medication, avoiding the risk of liver and kidney toxicity.

[0045] The above descriptions are merely embodiments of the present invention and are not intended to limit the patent scope of the present invention. Any equivalent transformations made using the contents of the present invention's specification and drawings, or directly or indirectly applied in related technical fields, are also included in the patent protection scope of the present invention.

Claims

1. A Chinese medicine composition for treating prostatic hypertrophy, characterized in that: Calculated by weight, the effective ingredients include 10-18 parts of centipedes, 20-30 parts of earthworms, 25-35 parts of lycopene, 15-25 parts of cicada shells, 10-18 parts of Poria cocos and 1-3 parts of dog whip.

2. The Chinese medicine composition for treating prostatic hypertrophy according to claim 1, characterized in that: The centipede is a roasted centipede.

3. The Chinese medicine composition for treating prostatic hypertrophy according to claim 1, characterized in that: The dog whip is made from wine.

4. The Chinese medicine composition for treating prostatic hypertrophy according to claim 1, characterized in that: Calculated by weight, the effective ingredients include 12-16 parts of centipedes, 22-26 parts of earthworms, 28-32 parts of lycopene, 18-22 parts of cicada shells, 12-16 parts of poria cocos and 1.5-2.5 parts of dog penis.

5. The Chinese medicine composition for treating prostatic hypertrophy according to claim 1, characterized in that: The dosage form is powder, tablet, pill, capsule or granule.

6. Use of the Chinese medicine composition according to claim 1 in the preparation of a medicament for treating prostatic hypertrophy.

7. A method for preparing a Chinese medicine composition for treating prostatic hypertrophy, characterized in that: The following steps are involved: S1. Crush centipedes, earthworms, cicada shells, Poria cocos and dog whips respectively; S2. Mix 10-18 parts of centipedes, 20-30 parts of earthworms, 25-35 parts of lycopene, 15-25 parts of cicada shells, 10-18 parts of Poria cocos and 1-3 parts of dog whip by weight to obtain a mixture; S3. Sterilize the mixture to obtain a Chinese medicinal composition for treating prostatic hypertrophy.

8. The method for preparing the Chinese medicine composition for treating prostatic hypertrophy according to claim 7, characterized in that: After the pulverization in S1, the step of passing through a 80-100 mesh sieve is also included.

9. The method for preparing the Chinese medicine composition for treating prostatic hypertrophy according to claim 7, characterized in that: The sterilization described in S3 is high temperature instantaneous sterilization.

10. The method for preparing the Chinese medicine composition for treating prostatic hypertrophy according to claim 9, characterized in that: The temperature of the high temperature instantaneous sterilization is 140-180° C. and the time is 5-20 seconds.

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