Animal fixator and animal fixing device

Abstract

The invention discloses an animal fixator, which comprises a fixator main body, an animal fixing cavity is defined in the fixator main body, and the fixator main body is provided with a positioning slot communicated with the animal fixing cavity; the positioning inserting plate is movably inserted into the positioning inserting groove, the positioning inserting plate is suitable for extending into the animal fixing cavity, the animal fixing cavity comprises a head fixing area and a body fixing area which are located on the two sides of the positioning inserting plate, and the positioning inserting plate is provided with a neck positioning notch; the pushing piece is movably installed in the animal fixing cavity, and the pushing piece is suitable for moving in the direction close to or away from the positioning inserting groove; and the cover plate is movably mounted at the top of the fixator main body. According to the animal fixing device, an animal can be fixed in the animal fixing cavity, the head cannot rotate, the animal does not need to be anesthetized, operation is easy, consumed time is short, the experiment efficiency is improved, fixing is firm, and the risks of biting and the like possibly caused by manual grabbing are avoided.

Description

Technical Field

[0001] The present invention relates to the technical field of fixing equipment, in particular to an animal fixing device and an animal fixing apparatus having the animal fixing device. Background Art

[0002] Mouse skull light irradiation is often used in non-genetic physical neuromodulation techniques, such as photobiomodulation therapy, which aims to make photons reach target brain areas (such as hippocampus, thalamus, etc.) through in vitro transcranial irradiation. The single irradiation time ranges from tens of seconds to one hour. During this process, the animal needs to be fixed, and there must be no obstruction between the light path and the skull. In the related technology, there is a method of simply placing the mouse after anesthesia, but it is difficult to observe the activity and reaction of the mouse during the irradiation process after anesthesia, and there is also a method of fixing the mouse by manual grasping, but this method is not only labor-intensive, but also manual operation is easy to cause obstruction to the experimental equipment, and there is a risk of being bitten by the mouse and laser irradiation, so there is room for improvement. Therefore, corresponding devices are needed to meet the requirements of animal irradiation in photobiomodulation therapy, or to meet the requirements of awake mouse experiments with head fixation. Summary of the invention

[0003] The present invention aims to solve at least one of the technical problems existing in the prior art. To this end, the present invention proposes an animal fixator, which is simple to operate, takes a short time, can improve the experimental efficiency, and is firmly fixed, especially the head will not rotate, and avoids the risk of bites and the like caused by manual grasping, and has a simple structure, convenient disassembly and assembly, good use effect, strong versatility, and can be used alone or in combination.

[0004] An animal fixator according to an embodiment of the present invention comprises: a fixator body, wherein an animal fixation cavity is defined in the fixator body, and the fixator body is provided with a positioning slot connected to the animal fixation cavity; a positioning plug plate, which can be movably plugged into the positioning slot, the positioning plug plate is suitable for extending into the animal fixation cavity, and the animal fixation cavity includes a head fixing area and a body fixing area located on both sides of the positioning plug plate, and the positioning plug plate is provided with a neck positioning recess; a push member, which can be movably installed in the animal fixation cavity, and the push member is suitable for moving in a direction close to or away from the positioning slot; a cover plate, which can be movably installed on the top of the fixator body, and the cover plate is suitable for manual loading and unloading.

[0005] According to the animal fixator of the embodiment of the present invention, the animal can be fixed in the animal fixing cavity by setting the positioning plug plate and the positioning slot for positioning cooperation. The whole process does not require anesthesia of the animal. The operation is simple and the time is short. The experimental efficiency can be improved. The fixation is firm, especially the head will not rotate, and the risk of bites and the like caused by manual grasping can be avoided. The structure is simple, the assembly and disassembly is convenient, the use effect is good, the versatility is strong, and the animal can be used alone or in combination.

[0006] According to some embodiments of the animal fixator of the present invention, the fixator body includes a head end cover and a fixing tube, the positioning slot is formed on the peripheral wall of the fixing tube, the head end cover is detachably mounted on one end of the fixing tube to open or close the head fixing area, and the pushing member is movably mounted on the other end of the fixing tube.

[0007] According to some embodiments of the animal fixator of the present invention, the head end cover is constructed as a conical end cover, the head fixing area includes a head avoidance opening formed in the conical end cover, the head avoidance opening is constructed as a conical opening, and the outer diameter of the head avoidance opening is set to gradually decrease in the direction away from the positioning slot.

[0008] According to some embodiments of the animal fixator of the present invention, the head end cover is formed with a vent at an end away from the fixing tube.

[0009] According to some embodiments of the animal fixator of the present invention, there are a plurality of the positioning plug-in plates and the positioning slots, and the plurality of positioning plug-in plates and the plurality of positioning slots are matched one-to-one;

[0010] Wherein, the plurality of positioning plug-in plates are distributed in sequence in the circumferential direction of the fixer body, and the neck positioning recesses of the plurality of positioning plug-in plates are spliced ​​into an oval positioning opening.

[0011] According to some embodiments of the animal fixator of the present invention, there are two positioning plug-in plates and two positioning slots, and the two positioning plug-in plates and the two positioning slots are matched one-to-one;

[0012] The two positioning plug-in plates are directly opposite to each other along the radial direction of the fixer body, and the neck positioning recesses of the two positioning plug-in plates are suitable for being spliced ​​into an oval positioning opening along the radial direction of the fixer body.

[0013] According to some embodiments of the animal fixator of the present invention, the pushing member includes a pushing plate portion, a pushing grip portion and a connecting portion, the fixator body is also provided with a pushing guide groove connected to the animal fixation cavity, the pushing plate portion is connected to the pushing grip portion via a connecting portion, the connecting portion is passed through the pushing guide groove and is movable along the pushing guide groove, the pushing plate portion is located in the animal fixation cavity for pushing the animal, and the pushing grip portion is located outside the animal fixation cavity.

[0014] According to some embodiments of the animal fixator of the present invention, the cover plate is made of opaque material, and is provided with a light-transmitting hole and two connecting slots, and the light-transmitting hole is used to transmit light toward the head of the animal, and the two connecting slots are matched with the fixator body and the positioning plug plate in a one-to-one correspondence.

[0015] The invention also provides an animal fixing device.

[0016] The animal fixing device according to the embodiment of the present invention comprises a fixing tray and an animal fixing device according to any one of the above embodiments, wherein the animal fixing device is arranged above the fixing tray.

[0017] According to some embodiments of the animal fixing device of the present invention, there are multiple animal fixators, and the multiple animal fixators are spaced apart and distributed in the circumferential direction of the fixing tray, and the fixator body extends radially along the fixing tray, and the head fixing area is located at one end of the body fixing area close to the center of the fixing tray.

[0018] The animal fixing device according to some embodiments of the present invention further includes a fixing bracket, wherein the fixing bracket is movable along the radial direction of the fixing tray, and the animal fixing device is detachably mounted on the fixing bracket.

[0019] Additional aspects and advantages of the present invention will be given in part in the following description and in part will be obvious from the following description, or will be learned through practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] The above and / or additional aspects and advantages of the present invention will become apparent and easily understood from the description of the embodiments in conjunction with the following drawings, in which:

[0021] Figure 1 is a schematic structural diagram of an animal fixator according to an embodiment of the present invention;

[0022] Figure 2 is a front view of an animal fixator according to an embodiment of the present invention;

[0023] Figure 3 is a top view of an animal fixator according to an embodiment of the present invention;

[0024] Figure 4 is a schematic diagram of the use of an animal fixator according to an embodiment of the present invention;

[0025] Figure 5 Schematic diagram of the use of an animal fixing device according to an embodiment of the present invention.

[0026] Reference numerals:

[0027] Animal Fixing Device 1000,

[0028] Animal Fixer 100,

[0029] Fixer body 1, animal fixing cavity 11, head fixing area 111, body fixing area 112, head end cover 12, air vent 121, fixing tube 13, positioning slot 131, pushing guide groove 14, connecting piece 15, positioning plug-in board 2, neck positioning notch 21, pushing piece 3, pushing plate part 31, pushing grip part 32, connecting part 33, cover plate 4, light transmission hole 41, connecting slot 42,

[0030] Fixed tray 200, center hole 201, sliding guide groove 202, fixed bracket 300, receiving groove 301, bottom plate 302, side plate 303, fixed notch 304,

[0031] Mouse 2000. DETAILED DESCRIPTION

[0032] Embodiments of the present invention are described in detail below, examples of which are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and cannot be understood as limiting the present invention.

[0033] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise", "axial", "radial", "circumferential" and the like indicate positions or positional relationships based on the positions or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention. In addition, features defined as "first" and "second" may explicitly or implicitly include one or more of the features. In the description of the present invention, unless otherwise specified, "multiple" means two or more.

[0034] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0035] Reference below Figure 1-Figure 5 The animal fixator 100 according to an embodiment of the present invention is described. By setting a positioning plug plate 2 and positioning the positioning slot 131, the animal can be fixed in the animal fixing cavity 11. The whole process does not require anesthesia of the animal. The operation is simple and time-saving, which can improve the experimental efficiency. The animal is firmly fixed, especially the head will not rotate, and the risk of bites caused by manual grasping can be avoided.

[0036] like Figure 1-Figure 5 As shown, an animal fixator 100 according to an embodiment of the present invention includes: a fixator body 1, a positioning plug plate 2, a pusher 3 and a cover plate 4.

[0037] An animal fixing cavity 11 is defined in the fixator body 1, wherein the animal fixing cavity 11 can be used to accommodate animals, such as mice 2000, rats, ferrets, etc. The fixator body 1 serves as a tool, an instrument, etc. for fixing animals, and an animal fixing cavity 11 is formed therein. The size and shape of the animal fixing cavity 11 will be set according to the body shape of the animal and the experimental requirements to ensure that the animal can be securely fixed in an appropriate position during the experiment.

[0038] The fixer body 1 is provided with a positioning slot 131 connected with the animal fixing cavity 11. For example, the positioning slot 131 may be a plug slot or other through hole, and the positioning slot 131 is connected with the animal fixing cavity 11, so that the animal in the animal fixing cavity 11 can be fixed through the positioning slot 131. The fixing position of the animal may be the head, limbs or tail, etc., and the setting position of the positioning slot 131 is not fixed, and can be selectively set according to different fixing parts of the animal to fix the animal accordingly. In this way, by setting the positioning slot 131, the accurate position of the animal in the fixer body can be ensured.

[0039] The positioning plug-in board 2 can be movably plugged into the positioning slot 131. The positioning plug-in board 2 is suitable for extending into the animal fixing cavity 11, and the animal fixing cavity 11 includes a head fixing area 111 and a body fixing area 112 located on both sides of the positioning plug-in board 2. The positioning plug-in board 2 is provided with a neck positioning recess 21.

[0040] Specifically, the positioning slot 131 passes through the fixing frame body, the positioning plug-in board 2 is plugged into the positioning slot 131, and can move relative to the positioning slot 131, wherein the animal fixing cavity 11 includes a connected head fixing area 111 and a body fixing area 112, both fixing areas can accommodate animals, during installation, the head of the animal is aligned with the head fixing area 111, and the body of the animal is aligned with the body fixing area 112, and the positioning plug-in board 2 is provided with a neck positioning recess 21, the neck positioning recess 21 is used to fix the fixed part of the animal, in actual design, the neck positioning recess 21 can be set to be recessed in a direction away from the animal fixing cavity 11, forming a groove, a pit or the like, so that the positioning plug-in board 2 can be in close contact with the body of the animal for easy fixation.

[0041] In this way, the animal can be fixed by the neck positioning notch 21 of the positioning plug-in board 2, and the movement of the animal can be restricted, making the animal fixed more reliably, and the insertion depth of the positioning plug-in board 2 relative to the positioning slot 131 can be adjusted to adapt to the fixation of animals of different sizes. Among them, the positioning plug-in board 2 can be fixed between the head fixing area 111 and the body fixing area 112 of the animal, and can also be fixed in both the head fixing area 111 and the body fixing area 112. And setting the head fixing area 111 and the body fixing area 112 can make the installation of the animal more convenient and quick.

[0042] The pusher 3 is movably installed in the animal fixing chamber 11, and the pusher 3 is suitable for moving in a direction close to or away from the positioning slot 131. When the animal is to be fixed, the pusher 3 is moved in a direction close to the positioning slot 131, and when the experiment is over and the animal is removed, the pusher 3 is moved in a direction away from the positioning slot 131.

[0043] Specifically, the pusher 3 can be completely accommodated in the animal fixing cavity 11, a part of the structure of the pusher 3 can also be located outside the animal fixing cavity 11, and the pusher 3 can move relative to the animal fixing cavity 11, and its movement mode can be linear motion.

[0044] The cover plate 4 can be movably mounted on the top of the fixture body 1, and the cover plate 4 is suitable for manual installation and removal. In this way, after the animal is fixed inside the fixture body 1, the cover plate 4 can be installed on the top of the fixture body 1 to cover the top of the fixture body 1 to meet the requirements of conducting experiments in a specific experimental environment. After the experiment is over, the cover plate 4 can be removed from the fixture body 1 by hand, making the installation and removal simpler and more convenient.

[0045] It should be noted that the cover 4 can be used for irradiating specific parts of a single animal, or for irradiating a large area of ​​multiple animals. In this way, irrelevant parts of the animal can be shielded in different experiments, which is conducive to improving the accuracy of animal experiments.

[0046] Among them, the animal fixator 100 in this embodiment is described by fixing the mouse 2000 and is applied to the mouse 2000 experiment. Among them, the cranial light irradiation of the mouse 2000 is often used in the non-genetic physical neuromodulation technology - photobiomodulation therapy, which aims to make photons reach the target brain area (such as hippocampus, thalamus, etc.) through in vitro transcranial irradiation. The single irradiation time ranges from tens of seconds to one hour. During this process, the animal needs to be fixed, and there must be no obstruction between the light path and the skull (including but not limited to transparent acrylic material).

[0047] Thus, before the experiment, the animal is first placed in the animal fixing cavity 11, and the pusher 3 moves in the direction close to the positioning slot 131, so that the animal can be pushed to move relative to the animal fixing cavity 11, and after the animal moves to the designated position, the side of the positioning plug board 2 provided with the neck positioning notch 21 is plugged into the positioning slot 131, and the positioning plug board 2 extends into the animal fixing cavity 11, and the neck positioning notch 21 is positioned on the animal body, and the cover plate 4 can also be connected to the top of the fixer body 1 at the end to fix the animal. When the experiment is over, the cover plate 4 is removed relative to the fixer body 1, and the pusher 3 is pushed in the reverse direction to release the fixation of the animal, and the animal can leave on its own.

[0048] Thus, the movement of the animal can be restricted by the above-mentioned fixing method, making the fixing of the animal more reliable, and the rotation of the animal's head can be restricted by positioning the plug board 2, thereby improving the repeatability and accuracy of the experiment. The setting method is simple, the operation is convenient, and there is no direct contact with the animal during operation, which is highly safe.

[0049] According to the animal fixator 100 of the embodiment of the present invention, the animal can be fixed in the animal fixing cavity 11 by setting the positioning plug plate 2 and positioning the positioning slot 131. The whole process does not require anesthesia for the animal. The operation is simple and the time is short. The experimental efficiency can be improved. The fixation is firm, especially the head will not rotate, and the risk of bites caused by manual grasping can be avoided. The structure is simple, the assembly and disassembly is convenient, the use effect is good, the versatility is strong, and the animal can be used alone or in combination.

[0050] In some embodiments, the fixer body 1 includes a head end cap 12 and a fixing tube 13, and a positioning slot 131 is formed on the peripheral wall of the fixing tube 13, so that the animal can be placed in the fixing tube 13, and the neck of the animal can be fixed by plugging the positioning plug plate 2 on the peripheral wall of the fixing tube 13. The head end cap 12 is detachably mounted on one end of the fixing tube 13 to open or close the head fixing area 111, that is, the head end cap 12 can be flexibly disassembled and installed so that the head fixing area 111 can be selectively opened.

[0051] Furthermore, the pusher 3 can be movably mounted on the other end of the fixed cylinder 13, and the pusher 3 can push the animal in the fixed cylinder 13 to the area close to the head end cover 12, so that the neck of the animal corresponds to the position of the positioning slot 131, and the head of the animal is located in the head end cover 12. The head end cover 12 and the fixed cylinder 13 can be provided with connecting flanges at the end faces facing each other, and can be connected and fixed by a connecting member 15 penetrating the connecting flange, which is convenient for disassembly, and the connecting member 15 can be provided in plurality to improve the connection stability.

[0052] That is to say, in actual design, the animal can be fixed in the fixing tube 13, and then the animal can be pushed to the target position by the pusher 3, and the neck of the animal can be fixed by the positioning plug board 2, so that the head of the animal is in the head fixing area 111. At this time, the head end cover 12 can be removed from the fixing tube 13, so that the head of the animal can be exposed outside the fixing tube 13, and then the laser light source in the experimental instrument can be aimed at the head of the animal for laser irradiation. The cover plate 4 can also be installed on the top of the fixer body 1, and the specific part of the animal can be irradiated by the laser light source. The setting method can be selected according to the actual experimental needs to meet the different needs of different experiments.

[0053] In this way, the animals can be effectively fixed and different movements of the animals can be ensured in a waking state, which is beneficial to improving the reliability and accuracy of the irradiation experiment.

[0054] Specifically, Figure 1-Figure 4 As shown, in actual experiments, the fixed cylinder 13 can be placed horizontally in the left-right direction, and the head end cover 12 can be detachably connected to the left end of the fixed cylinder 13, the pushing member 3 is at the right end of the fixed cylinder 13 and can move in the left-right direction to achieve the pushing and fixing of the animal, and the laser light source can be arranged at the upper left of the fixed cylinder 13 to irradiate the head of the animal, with a simple structure and convenient fixing.

[0055] In some embodiments, the head end cover 12 is constructed as a conical end cover, and the head fixing area 111 includes a head avoidance opening formed in the conical end cover, that is, after the head end cover 12 is connected and fixed to the fixing tube 13, a part of the head fixing area 111 is located in the fixing tube 13, and the other part is located in the head avoidance opening of the head end cover 12.

[0056] Specifically, Figure 4 As shown, the head end cover 12 is connected to the left end of the fixing tube 13, and the positioning plug plate 2 is located in the left end area of ​​the fixing tube 13 and is spaced apart from its left end surface, that is, the head fixing area 111 on the left side of the positioning plug plate 2 is formed in the space formed by the conical end cover, the fixing tube 13 and the left side surface of the positioning plug plate 2 to accommodate the head of the animal.

[0057] Furthermore, the head avoidance opening is configured as a tapered opening, and the outer diameter of the head avoidance opening is configured to gradually decrease in the direction away from the positioning slot 131. Thus, after the head end cover 12 is connected to the fixing tube 13, the head avoidance opening inside the head end cover 12 can effectively avoid the head of the animal, and the head avoidance opening is configured as a tapered opening, so that the shape of the tapered opening can be adapted to the shape of the animal's head, thereby preventing the animal's head from being squeezed.

[0058] Among them, taking mouse 2000 as an example, the mouth of mouse 2000 is relatively pointed, and the mouth is located at the front end of the head of mouse 2000. In this way, after the head of mouse 2000 is pushed into the head fixing area 111, the head of mouse 2000 can have sufficient avoidance space, avoiding the mouth of mouse 2000 from being squeezed against the head end cover 12 when mouse 2000 is pushed toward the head end cover 12 by the pushing member 3, thereby ensuring the safety of mouse 2000.

[0059] In some embodiments, the head end cap 12 is formed with an air vent 121 at one end away from the fixing tube 13, so that the air vent 121 can supply air toward the head end cap 12. It is understandable that after the head end cap 12 is connected to the fixing tube 13, and during the process of fixing the animal and adjusting the animal to the target position, the nose and mouth of the animal can be directed toward the air vent 121, that is, the animal is ensured to be in a normal oxygen supply state, avoiding the situation of insufficient oxygen absorption and poor condition of the animal during the fixation process, and ensuring the accuracy of the experiment.

[0060] Among them, the specific size of the air vent 121 can be flexibly set according to needs, such as setting the air vent 121 to be larger than the mouth size of the animal so that the mouth of the animal can at least partially extend from the air vent 121, which can not only ensure that the animal can breathe sufficiently, but also can avoid the mouth of the animal well, effectively preventing the animal's mouth from being compressed.

[0061] In some embodiments, there are multiple positioning plug plates 2 and positioning slots 131, and the multiple positioning plug plates 2 and the multiple positioning slots 131 are matched one by one. That is, multiple positioning plug plates 2 can be set to be plugged and matched with the fixer body 1, so that the multiple positioning plug plates 2 can fix the animal together to improve the stability of the fixation.

[0062] Among them, multiple positioning plug plates 2 are distributed in sequence on the circumference of the fixator body 1, and the neck positioning recesses 21 of the multiple positioning plug plates 2 are spliced ​​into an oval positioning opening, that is, the multiple positioning plug plates 2 can fix the neck of the animal from different positions on the circumference of the fixator body 1, and the oval positioning opening formed together can form multi-directional fixation of the neck of the animal in the circumference, ensuring that the animal is in a stable state after fixation, thereby effectively limiting the activity space of the animal's head and ensuring the accuracy of the experiment.

[0063] Specifically, multiple positioning plug-in plates 2 are configured to be radially plugged into the fixed cylinder 13 to form a splicing fit in the circumferential direction. The number of positioning plug-in plates 2 can be flexibly set according to actual needs, such as being set to 3, 4, 5 or even more.

[0064] In some embodiments, there are two positioning plug plates 2 and two positioning slots 131, and the two positioning plug plates 2 and the two positioning slots 131 are matched one by one. That is, by setting two positioning plug plates 2 to be plugged and matched with the fixer body 1, the two positioning plug plates 2 can be used to fix the animal together, thereby achieving fixation at different angles and improving the stabilization effect.

[0065] Among them, the two positioning plug-in plates 2 are directly opposite to each other along the radial direction of the fixator body 1, and the neck positioning recesses 21 of the two positioning plug-in plates 2 are suitable for being spliced ​​into an oval positioning opening along the radial direction of the fixator body 1, that is, the two positioning plug-in plates 2 can fix the neck of the animal from both radial sides of the fixator body 1, and the oval positioning opening formed together can form multi-directional fixation of the neck of the animal in the circumferential direction, ensuring that the animal is in a stable state after fixation, thereby effectively limiting the activity space of the animal's head and ensuring the accuracy of the experiment.

[0066] And, in actual design, the two positioning plug-in boards 2 can be set to be plugged in along the up and down directions, such as Figure 1 , Figure 2 and Figure 4 As shown, one positioning plug-in plate 2 is located on the upper side of the fixing tube 13 and is suitable for being inserted downward, and the other positioning plug-in plate 2 is located on the lower side of the fixing tube 13 and is suitable for being inserted upward; alternatively, the two positioning plug-in plates 2 can also be plugged in along the horizontal direction, and the animal can also be fixed. Therefore, the arrangement of the positioning plug-in plates 2 and the positioning slots 131 can be flexibly arranged according to needs to ensure the reliability of animal positioning.

[0067] In some embodiments, the pushing member 3 includes a pushing plate portion 31, a pushing grip portion 32 and a connecting portion 33. The fixer body 1 is also provided with a pushing guide groove 14 connected to the animal fixing cavity 11. The pushing plate portion 31 and the pushing grip portion 32 are connected through the connecting portion 33. The connecting portion 33 is passed through the pushing guide groove 14 and is movable along the pushing guide groove 14. The pushing plate portion 31 is located in the animal fixing cavity 11 for pushing the animal, and the pushing grip portion 32 is located outside the animal fixing cavity 11.

[0068] Thus, the user can push the push grip portion 32 on the outside of the fixer body 1, so that the push grip portion 32 drives the connection portion 33 to slide in the push guide groove 14, and drives the push plate portion 31 to push the animal during the sliding process, so as to adjust the position of the animal in the fixer body 1. The push plate portion 31 is directly opposite to the head end cover 12 along the extension direction of the fixing tube 13, so that the push plate portion 31 can push the animal toward the head end cover 12, so as to position the head and tail of the animal.

[0069] Specifically, the push guide groove 14 is configured to extend along the length direction of the holder body, so that when the connecting portion 33 slides along the push guide groove 14, the push plate portion 31 can be close to or away from the head end cover 12. The width of the push guide groove 14 is configured to be greater than the width of the connecting portion 33, and less than the width of the push grip portion 32, and less than the width of the push plate portion 31, so as to ensure that the connecting portion 33 slides smoothly and stably along the push guide groove 14.

[0070] Furthermore, the push plate portion 31 can be configured as a circular plate, and the circumferential edge of the push plate portion 31 is in contact with the inner circumferential wall of the fixed tube 13, so that when the push plate portion 31 pushes the animal, the tail or other parts of the animal can be prevented from being located in the gap between the push plate portion 31 and the inner wall of the fixed tube 13, that is, the animal is prevented from being accidentally squeezed. The push grip portion 32 can be configured as a grip rod, and the grip rod can be arranged to be perpendicular to the connecting portion 33, such as the grip rod is arranged to be perpendicular to the axial direction of the fixed tube 13, so that the user can grip the push grip portion 32, and the structure is simple and easy to use.

[0071] In some embodiments, the cover 4 is made of opaque material, and is provided with a light-transmitting hole 41 and two connecting slots 42. The light-transmitting hole 41 is used to transmit light toward the animal's head, and the two connecting slots 42 are matched with the fixer body 1 and the positioning plug board 2 one by one.

[0072] Specifically, the cover plate 4 is made of opaque material. After the cover plate 4 is installed on the top of the fixator body 1, the top of the fixator body 1 and the head of the animal can be shielded from light, and irrelevant parts outside the experimental range can be effectively shielded, which is conducive to accurate detection of the parts to be detected.

[0073] The cover plate 4 is provided with a light-transmitting hole 41 for light to pass through the cover plate 4 to irradiate other specific parts of the animal such as the head, and the cover plate 4 is provided with two connection slots 42, which are respectively plugged with the fixture body 1 and the positioning plug-in board 2 to realize the installation of the cover plate 4 and the fixture body 1. The installation is simple and convenient, which can improve the assembly efficiency before the experiment. In addition, the bottom of the cover plate 4 can also be supported by the top of the pusher 3 to improve the stability of the connection between the cover plate 4 and the fixture body 1.

[0074] Specifically, Figure 1 As shown, the light-transmitting hole 41 can be arranged in the area near the head of the animal. The light-transmitting hole 41 can be constructed as a circular hole and penetrate the cover plate 4 in the up-down direction. The two connecting slots 42 are spaced apart and distributed, and one of the connecting slots 42 can be arranged corresponding to the connecting flange of the fixing tube 13 at the end near the head end cover 12, and the other connecting slot 42 is arranged corresponding to the positioning plug-in plate 2. In this way, the two connecting slots 42 can be respectively plugged and matched with the connecting flange and the positioning plug-in plate 2 on the fixer body 1 in the up-down direction, so that the cover plate 4 and the fixer body 1 can be connected and fixed, and the connection method is simple and easy to disassemble and assemble.

[0075] Therefore, for experiments on a single animal or multiple animals, the cover plate 4 can shield the parts irrelevant to the experiment, and through the light-transmitting holes 41 of the cover plate 4, laser irradiation of specific parts of a single animal or multiple animals can be achieved to complete experimental detection of specific parts of the animals, and in particular, the accuracy of irradiation of multiple animals can be improved, and the accuracy of experimental detection results of multiple animals can be improved.

[0076] The present invention also provides an animal fixing device 1000 .

[0077] The animal fixing device 1000 according to the embodiment of the present invention comprises a fixing tray 200 and an animal fixing device 100 of any of the above embodiments, and the animal fixing device 100 is arranged above the fixing tray 200, so that the animal fixing device 100 and the fixing tray 200 can be arranged together in an experimental environment.

[0078] The number of animal holders 100 can be one, two or more, so as to achieve observation of different numbers of animals. A laser light source can be arranged above the fixed tray 200 so that the laser can illuminate and observe the animals on the fixed tray 200.

[0079] Specifically, the fixed tray 200 can be configured as a rectangular tray, a circular tray or a tray of other shapes for easy installation. Also, the animal holder 100 can be configured to be fixed relative to the fixed tray 200 or to be flexibly movable relative to the fixed tray 200. The configuration is flexible and optional, which is conducive to adapting to different observation scenes.

[0080] In some embodiments, there are multiple animal fixers 100, and the multiple animal fixers 100 are spaced apart and distributed in the circumferential direction of the fixed tray 200, and the fixer body 1 extends radially along the fixed tray 200, and the head fixing area 111 is located at one end of the body fixing area 112 close to the center of the fixed tray 200, so as to achieve fixation and observation of multiple animals.

[0081] That is, in this embodiment, the fixed tray 200 can be set as a circular tray or having a circular area, that is, the fixed tray 200 has a center, and the multiple animal fixers 100 are distributed in sequence in the circumferential direction of the fixed tray 200. The multiple animal fixers 100 can be set to be at the same distance from the center of the fixed tray 200. A laser light source can be set above the center of the fixed tray 200 so that the head fixing areas 111 of the multiple animal fixers 100 are all within the irradiation range of the laser light source. In this way, the animals in the multiple animal fixers 100 can be irradiated by the same laser light source, which is beneficial to reduce the number of laser light sources set and reduce the setting cost, and multiple animals can be synchronously observed at the same time, which is beneficial to improve the observation efficiency.

[0082] Specifically, Figure 5 As shown, the fixed tray 200 is constructed as a circular tray, and a center hole 201 is formed in the middle of the circular tray, that is, the circular tray is constructed in a circular ring shape, and the animal fixers 100 can be set to 12, so that 12 animals can be fixed on the fixed tray 200 at the same time. Of course, in actual experiments, the 12 animal fixers 100 can be used flexibly, that is, it is not necessary to place animals in each animal fixer 100, and they can be flexibly arranged according to needs, such as placing animals in 1, 2 or more of the 12 animal fixers 100 to meet the observation needs in different situations.

[0083] Furthermore, the number of animal fixators 100 can be flexibly set, such as 4, 8, 16 or other numbers.

[0084] In some embodiments, the animal fixing device 1000 further includes a fixing bracket 300 , which is movable along the radial direction of the fixing tray 200 , and the animal fixing device 100 is detachably mounted on the fixing bracket 300 , that is, the animal fixing device 100 can be mounted on the fixing tray 200 through the fixing bracket 300 .

[0085] It is understandable that the laser light source is disposed above the fixed tray 200, and the fixed bracket 300 moves relative to the fixed tray 200, so that the position of the animal on the animal holder 100 relative to the laser light source can be flexibly adjusted, so that the head of the animal on the animal holder 100 can be close to or away from the laser light source, and the position of the head of the animal can be flexibly adjusted to ensure the accuracy and reliability of observation. And through the cover plate 4 provided on each animal holder 100, the light source can be more accurately irradiated to the specific part of each animal through the cover plate 4, which can effectively improve the accuracy and reliability of observation.

[0086] When the animal fixator 100 is fixing an animal, the fixing bracket 300 can be moved in a direction away from the irradiation range of the laser light source, such as moving the fixing bracket 300 and the animal fixator 100 radially outward along the fixing tray 200, so that the animal fixator 100 is located outside the irradiation range of the laser light source to avoid being irradiated by the laser when manually fixing the animal; and after the animal is fixed, the fixing bracket 300 drives the animal fixator 100 to move towards the laser irradiation range, such as moving radially inward along the fixing tray 200, which is conducive to effective observation of the animal.

[0087] Specifically, Figure 5 As shown, a plurality of sliding guide grooves 202 may be provided on the fixed tray 200, and the plurality of sliding guide grooves 202 are spaced apart and distributed along the circumference of the fixed tray 200, and a fixed bracket 300 is provided at each sliding guide groove 202, and the fixed bracket 300 can slide relative to the sliding guide groove 202. At the same time, a plurality of animal fixers 100 are installed one by one on the fixed brackets 300 at the plurality of sliding guide grooves 202, so that the plurality of fixed brackets 300 can flexibly drive the plurality of animal fixers 100 to move relative to the fixed tray 200, and then perform laser irradiation observation after approaching the center of the fixed tray 200.

[0088] And, if Figure 5 As shown, the fixing bracket 300 can be constructed with a receiving groove 301, and the fixing bracket 300 includes a bottom plate 302 and two side plates 303, and the two side plates 303 are connected to the two ends of the bottom plate 302 and are distributed in parallel and spaced apart, wherein both side plates 303 can be provided with a fixing recess 304, or a fixing groove is provided on one of the side plates 303 located on the inner side, and the animal fixer 100 can be supported at the fixing recess 304, thereby realizing the installation of the animal fixer 100 relative to the fixing bracket 300, with a simple structure and convenient installation.

[0089] In the description of this specification, the description with reference to the terms "one embodiment", "some embodiments", "illustrative embodiments", "examples", "specific examples", or "some examples" means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described may be combined in any one or more embodiments or examples in a suitable manner.

[0090] Although the embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the claims and their equivalents.

Claims

1. An animal fixator, characterized in that: include: A fixator body, wherein an animal fixing cavity is defined in the fixator body, and the fixator body is provided with a positioning slot communicating with the animal fixing cavity; A positioning plug-in plate, the positioning plug-in plate can be movably plugged into the positioning slot, the positioning plug-in plate is suitable for extending into the animal fixing cavity, and the animal fixing cavity includes a head fixing area and a body fixing area located on both sides of the positioning plug-in plate, and the positioning plug-in plate is provided with a neck positioning notch; A pushing member, which is movably mounted in the animal fixing cavity and is suitable for moving in a direction approaching or away from the positioning slot; A cover plate is movably mounted on the top of the fixture body and is suitable for manual loading and unloading.

2. The animal fixator according to claim 1, characterized in that: The fixer body includes a head end cover and a fixing tube, the positioning slot is formed on the peripheral wall of the fixing tube, the head end cover is detachably mounted on one end of the fixing tube to open or close the head fixing area, and the pusher is movably mounted on the other end of the fixing tube.

3. The animal fixator according to claim 2, characterized in that: The head end cover is configured as a conical end cover, the head fixing area includes a head avoidance opening formed in the conical end cover, the head avoidance opening is configured as a conical opening, and the outer diameter of the head avoidance opening is configured to gradually decrease in a direction away from the positioning slot.

4. The animal holder according to claim 2, characterized in that: The head end cover is formed with a vent at one end away from the fixing tube.

5. The animal holder according to claim 1, characterized in that: There are multiple positioning plug-in plates and multiple positioning slots, and the multiple positioning plug-in plates and the multiple positioning slots are matched one by one; Wherein, the plurality of positioning plug-in plates are distributed in sequence in the circumferential direction of the fixer body, and the neck positioning recesses of the plurality of positioning plug-in plates are spliced ​​into an oval positioning opening.

6. The animal holder according to claim 1, characterized in that: There are two positioning plug-in plates and two positioning slots, and the two positioning plug-in plates and the two positioning slots are matched one by one; The two positioning plug-in plates are directly opposite to each other along the radial direction of the fixer body, and the neck positioning recesses of the two positioning plug-in plates are suitable for being spliced ​​into an oval positioning opening along the radial direction of the fixer body.

7. The animal holder according to claim 1, characterized in that: The pushing member includes a pushing plate portion, a pushing grip portion and a connecting portion. The fixer body is also provided with a pushing guide groove connected to the animal fixing cavity. The pushing plate portion is connected to the pushing grip portion through a connecting portion. The connecting portion is passed through the pushing guide groove and is movable along the pushing guide groove. The pushing plate portion is located in the animal fixing cavity for pushing the animal, and the pushing grip portion is located outside the animal fixing cavity.

8. The animal holder according to claim 1, characterized in that: The cover plate is made of an opaque material and is provided with a light-transmitting hole and two connecting slots. The light-transmitting hole is used to transmit light toward the head of the animal. The two connecting slots are matched with the fixer body and the positioning plug board in a one-to-one correspondence.

9. An animal fixing device, characterized in that: The invention comprises a fixed tray and the animal fixer according to any one of claims 1 to 8, wherein the animal fixer is arranged above the fixed tray.

10. The animal securing device according to claim 9, characterized in that: There are multiple animal fixators, and the multiple animal fixators are spaced apart and distributed in the circumferential direction of the fixed tray, and the fixator body extends radially along the fixed tray, and the head fixing area is located at one end of the body fixing area close to the center of the fixed tray.

11. The animal securing device according to claim 10, characterized in that: It also comprises a fixing bracket, which is movable along the radial direction of the fixing tray, and the animal fixer is detachably mounted on the fixing bracket.

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