Traditional Chinese medicine preparation for treating stomach illness and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine preparation for treating stomach diseases and a preparation method thereof, and belongs to the technical field of Chinese herbal medicines. The preparation is obtained by mixing and decocting amomum cardamomum, fingered citron, galangal, radix puerariae, radix bupleuri, pericarpium citri reticulatae and propolis. Through the compatibility, the preparation can effectively relieve stomach running pressure, promote digestion, clear away heat and toxic materials and harmonize the stomach to relieve pain, has a remarkable curative effect on stomachache, gasteremphraxis, gastric acid, 12-finger gastric ulcer, gastritis, gastroenteritis and other symptoms, and has the advantages of easily available medicinal raw materials, good compatibility, good stability, no toxic or side effect, low cost, remarkable curative effect and wide application prospect. Therefore, the traditional Chinese medicine composition is worthy of wide clinical popularization and application.

Description

Technical Field

[0001] The invention belongs to the technical field of Chinese herbal medicines, and particularly relates to a Chinese medicine preparation for treating gastric diseases and a preparation method thereof. Background Art

[0002] Gastric disease, including stomach pain, bloating, stomach acid, indigestion, 12 refers to gastric ulcer, gastritis, gastroenteritis, etc. Stomach pain, also known as epigastric pain, refers to a disease with pain in the epigastric area near the heart as the main symptom. Epigastric pain is a common clinical disease and a major symptom, often accompanied by upper abdominal distension, poor appetite, nausea, vomiting, noise, acid reflux, belching and other symptoms. Common diseases that cause epigastric pain in modern medicine include acute and chronic gastritis, peptic ulcer, functional dyspepsia, gastroptosis, etc.

[0003] Currently, most of the drugs used to treat stomach problems such as stomachache, bloating, and stomach acid are Western medicines. The prices of Western medicines are often relatively expensive, and they only treat the symptoms and not the root cause, and cannot completely cure the stomach problems.

[0004] Modern medicine believes that the onset of gastric disease is mostly related to Helicobacter pylori (Hp) infection, and studies have found that long-term Hp infection can increase the risk of intestinal metaplasia and even cancer. At present, modern medicine mainly treats gastric disease by inhibiting gastric acid secretion, protecting gastric mucosa, eradicating Hp, and symptomatic supportive treatment. Although it has a certain therapeutic effect, it is prone to recurrence and has a high incidence of adverse reactions. Therefore, the role of Western medicine in the treatment of gastric disease is relatively limited. Summary of the invention

[0005] The object of the present invention is to provide a Chinese medicine preparation for treating gastric disease, which is obtained by mixing white cardamom, bergamot, ginger, kudzu root, bupleurum, tangerine peel and propolis and then decocting. The preparation can effectively relieve the pressure of gastric operation, promote digestion, clear away heat and detoxify, soothe the stomach and relieve pain through the above-mentioned compatibility, and has significant therapeutic effects on symptoms such as stomachache, bloating, gastric acid, 12-finger gastric ulcer, gastritis, gastroenteritis, etc. The Chinese medicine preparation is easy to obtain, has good compatibility and stability, has no toxic and side effects, is low in cost, has significant efficacy, does not recur after being cured, and is worthy of being widely promoted and applied clinically.

[0006] The present invention is achieved through the following technical solutions:

[0007] A Chinese medicine preparation for treating gastric disease, wherein the Chinese medicine preparation is mainly prepared from the following raw materials in parts by weight:

[0008] 1-15 parts of white cardamom, 1-15 parts of bergamot, 0.7-10.5 parts of ginger, 1-15 parts of kudzu root, 1-15 parts of bupleurum, 4.2-63 parts of tangerine peel and 0.42-6.3 parts of propolis.

[0009] Preferably, the Chinese medicine preparation is mainly prepared from the following raw materials in parts by weight:

[0010] 3-12 parts of white cardamom, 3-12 parts of bergamot, 2.1-8.5 parts of ginger, 3-12 parts of kudzu root, 3-12 parts of bupleurum, 12.5-51 parts of tangerine peel and 1.25-5.1 parts of propolis.

[0011] Preferably, the Chinese medicine preparation is mainly prepared from the following raw materials in parts by weight:

[0012] 5-10 parts of white cardamom, 5-10 parts of bergamot, 3.5-7 parts of ginger, 5-10 parts of kudzu root, 5-10 parts of bupleurum, 21-42 parts of tangerine peel and 2.1-4.2 parts of propolis.

[0013] Preferably, the Chinese medicine preparation is mainly prepared from the following raw materials in parts by weight:

[0014] 7 parts of white cardamom, 7 parts of bergamot, 5 parts of ginger, 7 parts of kudzu root, 7 parts of bupleurum, 30 parts of tangerine peel and 3 parts of propolis.

[0015] White cardamom, the Chinese herbal medicine named as the mature fruit of Amomum kravanh Pierre ex Gagnep. and Amomum compactum Soland ex Maton. of the ginger family. It has the effects of removing dampness and promoting qi, warming the middle and stopping vomiting, and stimulating appetite and digestion. It is mainly used to treat dampness blocking qi stagnation, spleen and stomach disharmony, abdominal distension, loss of appetite, initial onset of damp-heat, chest tightness without hunger, stomach cold vomiting, and indigestion. It tastes spicy and warm in nature; it enters the lung, spleen, and stomach meridians. Effect on the stomach: Gavage of 10g / kg of white cardamom decoction to rats for 5 days can increase the gastric mucosal blood flow (GMBF) and serum gastrin in animals to varying degrees, and can also increase the SOD activity of gastric mucosal tissue and reduce the MDA content.

[0016] Buddha's hand, the Chinese medicine name is the dried fruit of Citrus medica L.var.sarcodactylis Swingle, a plant of the Rutaceae family. It has the effects of soothing the liver and relieving depression, regulating qi and harmonizing the middle, and drying dampness and resolving phlegm. It is mainly used for chest and flank distension and pain, abdominal distension and fullness caused by liver depression and qi stagnation and liver-stomach disharmony, abdominal distension and pain, nausea and loss of appetite caused by spleen and stomach qi stagnation, coughing for a long time with a lot of sputum, and chest pain. It tastes pungent, bitter, sour, and warm in nature; it enters the liver, spleen, and stomach. It contains volatile oils, flavonoids, polysaccharides, and coumarin compounds. The main ingredients are bergamot lactone, limonolactone, hesperidin, and bucuroside (diosmin).

[0017] Buddha's hand with tangerine peel: Buddha's hand is bitter and warm, and has the functions of soothing the liver and relieving depression, regulating qi and harmonizing the middle, and drying dampness and resolving phlegm; tangerine peel is bitter and warm, and has the functions of regulating qi and strengthening the spleen, and drying dampness and resolving phlegm. Buddha's hand has a mild medicinal property and is good at regulating the qi of the liver and stomach, while tangerine peel has a stronger medicinal property and is good at regulating spleen and stomach qi stagnation and strengthening the spleen. The two medicines are used together to enhance the functions of regulating qi, drying dampness and resolving phlegm. It is suitable for spleen and stomach or liver and stomach qi stagnation syndrome, cough with excessive phlegm, etc.

[0018] Alpinia officinarum Hance, also known as Galangal, is a dried rhizome of the plant Alpinia officinarum Hance of the Zingiberaceae family. It has the effects of dispelling cold and relieving pain, warming the middle and stopping vomiting. It is mainly used to treat stomach cold pain and stomach cold vomiting. It tastes spicy and is hot in nature; it enters the spleen and stomach meridians. It contains 0.5%-1.5% volatile oil, the main components of which are 1,8-cineole, methyl cinnamate, eugenol, pinene, cubebene and the spicy ingredient galangol. It also contains flavonoids such as galangin, kaempferol, kaempferol, quercetin, isorhamnetin, etc. The water extract of this product has analgesic and anti-inflammatory effects.

[0019] Pueraria root, the Chinese medicine name is the dried root of Pueraria lobata (Willd.) Ohwi, a plant of the genus Pueraria in the Leguminosae family. It has the effects of relieving muscle and fever, clearing rashes, promoting body fluid and quenching thirst, and raising yang and stopping diarrhea. It is mainly used to treat fever due to superficial symptoms, stiff neck and back pain, measles that does not clear up, thirst due to febrile diseases, thirst due to yin deficiency, hot diarrhea and dysentery, and diarrhea due to spleen deficiency. It tastes sweet and spicy, is cool in nature, and enters the spleen and stomach meridians. This product mainly contains flavonoids such as soybean glycoside, soybean aglycone, puerarin, etc., as well as soybean glycoside-4,7-diglucoside, puerarin-7-xyloside, puerarin alcohol, puerarin and isoflavone glycosides and starch. It has a significant antispasmodic effect on the isolated intestine of mice and can counteract intestinal spasm caused by acetylcholine. Pueraria root also has a significant antipyretic effect and a slight hypoglycemic effect.

[0020] Bupleurum chinensie DC. or Bupleurum scorzonerifolium Willd., a plant of the genus Bupleurum in the family Apiaceae, is a dried root of Bupleurum chinensie DC. or Bupleurum scorzonerifolium Willd. It has the effects of relieving fever, soothing the liver and relieving depression, and raising Yang Qi. It is mainly used to treat fever caused by superficial symptoms, Shaoyang syndrome, liver depression and qi stagnation, qi deficiency and sinking, organ prolapse, and antipyretic and antimalarial. It tastes bitter and pungent, and is slightly cold in nature; it enters the liver and gallbladder meridians. Bupleurum root contains α-spinasterol, springforestol, and saikosaponins a, c, d, as well as volatile oils. The root of bupleurum scorzonerifolium contains saikosaponins a, c, d, volatile oils, bupleurol, springforestol, α-spinasterol, etc.

[0021] Tangerine peel, the Chinese medicine name is the dried mature peel of Citrus reticulata Blanco and its cultivated varieties. It has the effects of regulating qi and strengthening the spleen, drying dampness and resolving phlegm. It is mainly used to treat spleen and stomach qi stagnation, vomiting, hiccups, damp phlegm, cold phlegm cough, and chest pain. It tastes spicy and bitter, and is warm in nature; it enters the spleen and lung meridians. Tangerine peel contains nobiletin, hesperidin, neohesperidin, hesperidin, hydroxyforin, flavonoid compounds, etc. The volatile oil content of tangerine peel is 1.5%-2.0%, and the volatile oil content of Guang tangerine peel is 1.2%-3.2%, and its components include α-thujacene, limonene, etc.

[0022] Propolis, a Chinese medicine named Apis cerana Fabr., is a yellow-brown or dark-brown sticky substance secreted by the honeycomb. It has the effects of moisturizing the skin, promoting muscle growth, and relieving inflammation and pain. It is mainly used to treat gastric ulcers, oral ulcers, cervical erosion, herpes zoster, psoriasis, skin cracks, corns, and burns. It is bitter, pungent, and cold; it enters the spleen and stomach meridians. Propolis contains flavonoids, phenols, lactones, coumarins, aldehydes, ketones, steroid compounds, vitamin B1, niacin, provitamin A, and various amino acids, sugars, polysaccharides, etc., as well as 34 essential elements. It has anti-pathogenic microbial effects, sedative, anesthesia and other nervous system effects, tissue repair promoting effects, liver protection, anti-tumor effects, and a certain effect on the cardiovascular system. In addition, propolis has a strong free radical scavenging effect, and the hydroalcoholic extract of propolis can accelerate the passage of barium sulfate through the digestive tract, indicating that propolis can promote gastrointestinal smooth muscle peristalsis and have a mild laxative effect.

[0023] A method for preparing a Chinese medicine preparation for treating gastropathy comprises the following steps:

[0024] The method comprises the following steps: selecting white cardamom, bergamot, ginger, kudzu root, bupleurum root, tangerine peel and propolis according to corresponding weight proportions, mixing the mixture and boiling the mixture, filtering out the residue and obtaining a medicinal solution.

[0025] Preferably, the decoction temperature is 85-100°C.

[0026] Preferably, the decoction time is 35 to 45 minutes per time.

[0027] Preferably, the decoction is performed 2 to 3 times.

[0028] Preferably, the preparation is an oral preparation.

[0029] Compared with the prior art, the present invention has at least the following technical effects:

[0030] The invention provides a Chinese medicine preparation for treating gastric disease, which is obtained by mixing white cardamom, bergamot, ginger, kudzu root, bupleurum, tangerine peel and propolis and then decocting. The preparation can effectively relieve the pressure of gastric operation, promote digestion, clear away heat and detoxify, soothe the stomach and relieve pain through the above-mentioned compatibility, and has significant therapeutic effects on symptoms such as stomachache, bloating, gastric acid, 12-finger gastric ulcer, gastritis, gastroenteritis, etc. The Chinese medicine preparation is easy to obtain, has good compatibility and stability, has no toxic side effects, is low in cost, has significant therapeutic effects, does not recur after being cured, and is worthy of being widely promoted and applied in clinic. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] Figure 1 This is the symptom situation of Case 1. DETAILED DESCRIPTION

[0032] The embodiments of the present invention will be described in detail below in conjunction with examples. However, those skilled in the art will understand that the following examples are only used to illustrate the present invention and should not be construed as limiting the scope of the present invention. The specific conditions not specified in the examples are carried out according to conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used without indicating the manufacturer are all conventional products that can be purchased commercially.

[0033] A specific implementation method

[0034] A Chinese medicine preparation for treating gastric disease, wherein the Chinese medicine preparation is mainly prepared from the following raw materials in parts by weight:

[0035] 1-15 parts of white cardamom, 1-15 parts of bergamot, 0.7-10.5 parts of ginger, 1-15 parts of kudzu root, 1-15 parts of bupleurum, 4.2-63 parts of tangerine peel and 0.42-6.3 parts of propolis.

[0036] Preferably, the Chinese medicine preparation is mainly prepared from the following raw materials in parts by weight:

[0037] 3-12 parts of white cardamom, 3-12 parts of bergamot, 2.1-8.5 parts of ginger, 3-12 parts of kudzu root, 3-12 parts of bupleurum, 12.5-51 parts of tangerine peel and 1.25-5.1 parts of propolis.

[0038] Preferably, the Chinese medicine preparation is mainly prepared from the following raw materials in parts by weight:

[0039] 5-10 parts of white cardamom, 5-10 parts of bergamot, 3.5-7 parts of ginger, 5-10 parts of kudzu root, 5-10 parts of bupleurum, 21-42 parts of tangerine peel and 2.1-4.2 parts of propolis.

[0040] Preferably, the Chinese medicine preparation is mainly prepared from the following raw materials in parts by weight:

[0041] 7 parts of white cardamom, 7 parts of bergamot, 5 parts of ginger, 7 parts of kudzu root, 7 parts of bupleurum, 30 parts of tangerine peel and 3 parts of propolis.

[0042] A method for preparing a Chinese medicine preparation for treating gastropathy comprises the following steps:

[0043] The method comprises the following steps: selecting white cardamom, bergamot, ginger, kudzu root, bupleurum root, tangerine peel and propolis according to corresponding weight proportions, mixing the mixture and boiling the mixture, filtering out the residue and obtaining a medicinal solution.

[0044] Preferably, the decoction temperature is 85-100°C.

[0045] Preferably, the decoction time is 35 to 45 minutes per time.

[0046] Preferably, the decoction is performed 2 to 3 times.

[0047] Preferably, the preparation is an oral preparation.

[0048] Embodiment 1:

[0049] A Chinese medicine preparation for treating gastric disease is prepared from the following raw materials in parts by weight:

[0050] 10g white cardamom, 10g bergamot, 7g ginger, 10g kudzu root, 10g bupleurum, 42g tangerine peel and 4.2g propolis.

[0051] A method for preparing a Chinese medicine preparation for treating gastropathy comprises the following steps:

[0052] The method comprises the following steps: selecting white cardamom, bergamot, ginger, kudzu root, bupleurum root, tangerine peel and propolis according to corresponding weight proportions, mixing the mixture and boiling the mixture, filtering out the residue and obtaining a medicinal solution.

[0053] The decoction temperature is 85°C.

[0054] The decoction time is 35 min / time.

[0055] The decoction times is 3 times.

[0056] The preparation is an oral preparation.

[0057] Embodiment 2:

[0058] A Chinese medicine preparation for treating gastric disease is prepared from the following raw materials in parts by weight:

[0059] 150g white cardamom, 150g bergamot, 105g ginger, 150g kudzu root, 150g bupleurum, 630g tangerine peel and 63g propolis.

[0060] A method for preparing a Chinese medicine preparation for treating gastropathy comprises the following steps:

[0061] The method comprises the following steps: selecting white cardamom, bergamot, ginger, kudzu root, bupleurum root, tangerine peel and propolis according to corresponding weight proportions, mixing the mixture and boiling the mixture, filtering out the residue and obtaining a medicinal solution.

[0062] The decoction temperature is 100°C.

[0063] The decoction time is 45 min / time.

[0064] The decoction times is 2 times.

[0065] The preparation is an oral preparation.

[0066] Embodiment 3:

[0067] A Chinese medicine preparation for treating gastric disease is prepared from the following raw materials in parts by weight:

[0068] 30g white cardamom, 30g bergamot, 21g ginger, 30g kudzu root, 30g bupleurum, 125g tangerine peel and 12.5g propolis.

[0069] A method for preparing a Chinese medicine preparation for treating gastropathy comprises the following steps:

[0070] The method comprises the following steps: selecting white cardamom, bergamot, ginger, kudzu root, bupleurum root, tangerine peel and propolis according to corresponding weight proportions, mixing the mixture and boiling the mixture, filtering out the residue and obtaining a medicinal solution.

[0071] The decoction temperature is 85°C.

[0072] The decoction time is 45 min / time.

[0073] The decoction times is 2 times.

[0074] The preparation is an oral preparation.

[0075] Embodiment 4:

[0076] A Chinese medicine preparation for treating gastric disease is prepared from the following raw materials in parts by weight:

[0077] 120g white cardamom, 120g bergamot, 85g ginger, 120g kudzu root, 120g bupleurum, 510g tangerine peel and 51g propolis.

[0078] A method for preparing a Chinese medicine preparation for treating gastropathy comprises the following steps:

[0079] The method comprises the following steps: selecting white cardamom, bergamot, ginger, kudzu root, bupleurum root, tangerine peel and propolis according to corresponding weight proportions, mixing the mixture and boiling the mixture, filtering out the residue and obtaining a medicinal solution.

[0080] The decoction temperature is 100°C.

[0081] The decoction time is 35 min / time.

[0082] The decoction times is 3 times.

[0083] The preparation is an oral preparation.

[0084] Embodiment 5:

[0085] A Chinese medicine preparation for treating gastric disease is prepared from the following raw materials in parts by weight:

[0086] 50g white cardamom, 50g bergamot, 35g galangal, 50g kudzu root, 50g bupleurum, 210g tangerine peel and 21g propolis.

[0087] A method for preparing a Chinese medicine preparation for treating gastropathy comprises the following steps:

[0088] The method comprises the following steps: selecting white cardamom, bergamot, ginger, kudzu root, bupleurum root, tangerine peel and propolis according to corresponding weight proportions, mixing the mixture and boiling the mixture, filtering out the residue and obtaining a medicinal solution.

[0089] The decoction temperature is 100°C.

[0090] The decoction time is 35 min / time.

[0091] The decoction times is 3 times.

[0092] The preparation is an oral preparation.

[0093] Embodiment 6:

[0094] A Chinese medicine preparation for treating gastric disease is prepared from the following raw materials in parts by weight:

[0095] 100g white cardamom, 100g bergamot, 70g galangal, 100g kudzu root, 100g bupleurum, 420g tangerine peel and 42g propolis.

[0096] A method for preparing a Chinese medicine preparation for treating gastropathy comprises the following steps:

[0097] The method comprises the following steps: selecting white cardamom, bergamot, ginger, kudzu root, bupleurum root, tangerine peel and propolis according to corresponding weight proportions, mixing the mixture and boiling the mixture, filtering out the residue and obtaining a medicinal solution.

[0098] The decoction temperature is 100°C.

[0099] The decoction time is 35 min / time.

[0100] The decoction times is 3 times.

[0101] The preparation is an oral preparation.

[0102] Embodiment 7:

[0103] A Chinese medicine preparation for treating gastric disease is prepared from the following raw materials in parts by weight:

[0104] White cardamom 7g, bergamot 7g, galangal 5g, kudzu root 7g, bupleurum 7g, tangerine peel 30g and propolis 3g.

[0105] A method for preparing a Chinese medicine preparation for treating gastropathy comprises the following steps:

[0106] The method comprises the following steps: selecting white cardamom, bergamot, ginger, kudzu root, bupleurum root, tangerine peel and propolis according to corresponding weight proportions, mixing the mixture and boiling the mixture, filtering out the residue and obtaining a medicinal solution.

[0107] The decoction temperature is 100°C.

[0108] The decoction time is 35 min / time.

[0109] The decoction times is 3 times.

[0110] The preparation is an oral preparation.

[0111] Usage: 5 grams each time, 2-3 times / day, orally. A course of treatment is 2 months.

[0112] Clinical cases:

[0113] Case 1: Jin, male, about 60-70 years old. Suffering from stomach disease. After taking the preparation prepared in Example 7, the symptoms were significantly improved. Figure 1 Feedback for this case.

[0114] Finally, it should be noted that the above description is only a preferred embodiment of the present invention and is not intended to limit the protection scope of the present invention. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A Chinese medicine preparation for treating gastropathy, characterized in that: The Chinese medicine preparation is mainly prepared from the following raw materials in parts by weight: 1-15 parts of white cardamom, 1-15 parts of bergamot, 0.7-10.5 parts of ginger, 1-15 parts of kudzu root, 1-15 parts of bupleurum, 4.2-63 parts of tangerine peel and 0.42-6.3 parts of propolis.

2. A Chinese medicine preparation for treating gastropathy according to claim 1, characterized in that: The Chinese medicine preparation is mainly prepared from the following raw materials in parts by weight: 3-12 parts of white cardamom, 3-12 parts of bergamot, 2.1-8.5 parts of ginger, 3-12 parts of kudzu root, 3-12 parts of bupleurum, 12.5-51 parts of tangerine peel and 1.25-5.1 parts of propolis.

3. A Chinese medicine preparation for treating gastropathy according to claim 2, characterized in that: The Chinese medicine preparation is mainly prepared from the following raw materials in parts by weight: 5-10 parts of white cardamom, 5-10 parts of bergamot, 3.5-7 parts of ginger, 5-10 parts of kudzu root, 5-10 parts of bupleurum, 21-42 parts of tangerine peel and 2.1-4.2 parts of propolis.

4. A Chinese medicine preparation for treating gastropathy according to claim 3, characterized in that: The Chinese medicine preparation is mainly prepared from the following raw materials in parts by weight: 7 parts of white cardamom, 7 parts of bergamot, 5 parts of ginger, 7 parts of kudzu root, 7 parts of bupleurum, 30 parts of tangerine peel and 3 parts of propolis.

5. A method for preparing a Chinese medicine preparation for treating gastropathy according to any one of claims 1 to 4, characterized in that: The steps include: The method comprises the following steps: selecting white cardamom, bergamot, ginger, kudzu root, bupleurum root, tangerine peel and propolis according to corresponding weight proportions, mixing the mixture and boiling the mixture, filtering out the residue and obtaining a medicinal solution.

6. The method for preparing a Chinese medicine preparation for treating gastropathy according to claim 5, characterized in that: The decoction temperature is 85-100°C.

7. The method for preparing a Chinese medicine preparation for treating gastropathy according to claim 6, characterized in that: The decoction time is 35 to 45 minutes per time.

8. The method for preparing a Chinese medicine preparation for treating gastropathy according to claim 7, characterized in that: The decoction times are 2 to 3 times.

9. The method for preparing a Chinese medicine preparation for treating gastropathy according to claim 5, characterized in that: The preparation is an oral preparation.

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