Preparation method of pyrazole intermediate

By introducing microchannel reactors in traditional processes, the problems of long reaction time, low efficiency, serious remix and carbonization in traditional processes are solved, and the efficient preparation of pyrazole intermediates and the improvement of product quality are achieved.

CN119661334APending Publication Date: 2025-03-21STATE NUCLEAR ELECTRIC POWER PLANNING DESIGN & RES INST CO LTD +1
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Patent Information

Application Number
CN202411222694.3
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-09-02
Publication Date
2025-03-21

AI Technical Summary

Technical Problem

The traditional production process of glycerol for preparation of 3-hydroxypropanaldehyde and acrolein has problems such as long reaction time, low efficiency, easy remixture, severe carbonization, and low yield.

Method used

The reaction was carried out using a microchannel reactor, and the aqueous glycerol solution and concentrated sulfuric acid solution containing a catalyst were passed into the microchannel reactor for dehydration, and the reaction product was collected to obtain a mixture of 3-hydroxypropanal and acrolein.

Benefits of technology

The reaction time is significantly shortened, the remixture, carbonization and violent exothermic phenomena are prevented, the yield of pyrazole intermediates and the quality of products are improved, the production efficiency is greatly improved, and the equipment volume is reduced.

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Abstract

The invention discloses a preparation method of a pyrazole intermediate, which comprises the following steps: respectively introducing a glycerol aqueous solution and a concentrated sulfuric acid solution containing a catalyst into a microchannel reactor for reaction to obtain the pyrazole intermediate, and the pyrazole intermediate comprises 3-hydroxypropionaldehyde and acrolein. According to the preparation method of the pyrazole intermediate, based on the efficient heat exchange performance of the microchannel reactor, the reaction time can be obviously shortened, and adverse phenomena such as back-mixing, carbonization and violent heat release in the reaction process can be prevented, so that the yield of the pyrazole intermediate is increased, and the production efficiency of the pyrazole intermediate is greatly improved.
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