Valve block for solution management system for biological treatment

Abstract

The present disclosure relates to a valve block (100) for controlling fluid flow into or out of a solution management system (200) for biological treatment, the valve block being a single unit and comprising: at least one inlet port (10); at least one outlet port (20); and four or more valve sections (30) fluidly connected to the at least one inlet port and the at least one outlet port, each valve section configured to receive a valve element (32) for controlling fluid passing through the valve block; wherein the at least two valve sections are fluidically connected to each other by means of an integrally formed first channel (40), which changes direction twice or more.

Description

Technical Field

[0001] This disclosure relates to a valve block for controlling fluid flow into and / or out of a solution management system for biological treatment, and a solution management system for biological treatment including such a valve block. More specifically, this disclosure relates to a valve block, and a solution management system for biological treatment including such a valve block, as defined in the introductory portion of the independent claims. Background Technology

[0002] Valve blocks are used in a variety of applications and are typically made of solid blocks. A valve block includes one or more inlet ports, outlet ports, and valves, which are connected by drilled channels within the valve block. These channels are straight, but a 90-degree change of orientation can be achieved by drilling two perpendicular channels to intersect them. Valve blocks are typically assembled or stacked on top of each other to achieve the desired flow path via the connected channels. However, assembled valve blocks require a sealing arrangement between them to prevent leakage.

[0003] In solution management systems used in biological treatments, valve blocks serve as solution inlets and / or outlets. Such systems may include multiple inlets and outlets for different solutions or fluids, and often combine multiple valve blocks. As mentioned earlier, combining valve blocks requires sealing devices. Sealing generally creates small gaps, which, in the worst case, become points of dirt accumulation, leading to cross-contamination. This presents a challenge for known valve blocks. Summary of the Invention

[0004] The purpose of this invention is to provide a valve block for a solution management system for biological processes that addresses or mitigates at least some of the challenges faced by conventional valve blocks for solution and buffer management in the pharmaceutical and biotechnology industries.

[0005] According to a first aspect of the invention, a valve block is provided for controlling fluid flow into and / or out of a solution management system for biological treatment in a sterile / sterile environment. The valve block is a single unit and includes: at least one inlet port; at least one outlet port; and four or more valve sections fluidly connected to the at least one inlet port and the at least one outlet port, each valve section configured to receive a valve element for controlling the flow of fluid through the valve block; wherein at least two valve sections are fluidly connected by means of an integrally formed first channel that changes direction two or more times.

[0006] By utilizing a single unit valve block (monolithic block) with four or more valve sections as disclosed herein, the integrally formed first channel, capable of changing direction two or more times, allows fluid within a single valve block to be transported in a more flexible and complex manner. For example, the first channel can bypass valve sections, channels, inlet ports, or outlet ports in the same plane within the valve block. Thus, valve sections, inlet ports, and outlet ports arranged non-adjacent to each other within the valve block can be fluidly connected in a space-saving manner. Therefore, without increasing the thickness of the valve block and bypass components in different planes, the first channel allows valve blocks as disclosed herein to be manufactured more compactly, using less material and thus reducing weight. This is advantageous from a sustainability perspective and will also facilitate the installation and maintenance of the valve block in a solution management system. The integrally formed first channel also enhances the ability to provide customized flow paths within the valve block, thereby reducing the need to combine multiple valve blocks. This avoids sealing and potential cross-contamination between different valve blocks.

[0007] The valve section in the valve block can be fluidly connected directly or indirectly to at least one inlet port and at least one outlet port. Therefore, the valve section can be directly connected to the inlet port and / or outlet port, or the valve section can be connected to the inlet port and / or outlet port via another valve section.

[0008] The first channel can have a substantially constant cross-sectional area. Therefore, even when changing direction, the cross-sectional area of ​​the first channel can remain substantially the same along its extension. This allows for reduced confinement of the flow in the first channel and lower back pressure.

[0009] In one example, at least two fluidly connected valve sections are arranged diagonally within a valve block. In conventional valve blocks, fluidly connecting two diagonally arranged valve sections can be difficult because it requires multiple intersecting straight drilled channels. By changing the direction of a first, integrally formed channel at least twice, diagonally arranged valve sections can be fluidly connected in a space-saving manner.

[0010] Four or more valve sections may be fluidly connected to each other. The valve sections may be fluidly connected via a centrally located channel that is fluidly connected to at least one inlet port and / or at least one outlet port. Alternatively, four or more valve sections may be fluidly connected to each other by means of different channels that connect them sequentially.

[0011] The valve block can be manufactured using additive manufacturing. Alternatively, it can be manufactured by molding or casting. By using additive manufacturing, molding, or casting, the valve block can be configured with the desired flow path in a space-saving manner. Thus, the valve block can be more compact and requires less material. Additive manufacturing or 3D printing can be performed using polypropylene (PP), polyetherketone (PEEK), stainless steel, or other materials compatible with typical biological treatment process fluids and cleaning agents. Because the valve block can be 3D printed or molded from different plastic materials, CO2 emissions are reduced compared to valve blocks that include metals. Furthermore, the valve block will be lighter in weight because it can be printed or molded from plastic. Additionally, by being able to form the channels more freely, the channels can be routed to have at least one inlet port and / or at least one outlet port located below the valve section. This improves the drainage performance of the valve block.

[0012] Such 3D printed parts may also be printed and / or surface treated to enable optimized cleanliness or minimized biocontaminant adhesion (e.g., by surface heat treatment, etc. - see WO2023 / 156477A1, PCT / EP24 / 050808, SE2350629-8 and / or WO2024 / 061643A1, which are incorporated herein by reference in their entirety).

[0013] In one example, the first channel is defined by a channel wall with a thickness between 1.6 mm and 5 mm. The thickness of the channel wall of the first channel can vary along the extension of the first channel. It should be understood that the first channel and any other channel in the valve block disclosed herein can be referred to as a conduit, pipe, or passage. All channels in the valve block can be defined by channel walls with a thickness between 1.6 mm and 5 mm. The first channel defined by a channel wall with a thickness between 1.6 mm and 5 mm makes this valve block different from conventional solutions, in which the channel is a hole drilled in a solid block. By forming a wall with a certain thickness, rather than removing material from a solid block (drilling), the valve block can be configured to be slightly hollow. This uses less material and reduces the weight of the valve block.

[0014] The channel wall defining the first channel can extend continuously along the longitudinal direction of the first channel. By making the first channel a continuous wall without joints or seals, better flow is achieved within the valve block, and the risk of leakage and contamination is reduced. Furthermore, the continuous wall allows for improved fluid flow within the channel.

[0015] In one example, the valve block also includes a second channel, wherein the first and second channels extend in different planes within the valve block and pass through each other without intersecting. The first channel, changing direction at least twice, allows for a more space-efficient arrangement of channels within the valve block. The second channel may be configured similarly to the first channel and therefore can change direction two or more times. Alternatively, the second channel may be configured differently from the first channel. The valve block may include multiple channels, which may be similar to or dissimilar to the first channel. Some channels may be straight, others may change direction only once, and still others may change direction three or more times.

[0016] The first channel may include at least two curved sections that change the direction of the first channel at least twice. The curved sections may be configured such that the first channel is substantially U-shaped or S-shaped. Each curved section may be configured to provide a substantially 90-degree change of direction. In some examples, the curved sections are configured to provide a change of direction between 45 and 135 degrees. The curved sections may be configured to provide a change of direction in the x, y, or z direction.

[0017] The first channel may include at least two curved sections that change the direction of the first channel at least twice, wherein at least one curved section is configured such that the radius of curvature varies along at least a portion of the length of the curved section. The radius of curvature of the at least one curved section can vary while maintaining a constant cross-sectional area of ​​the first channel. This avoids sharp bends or angles and allows for continuous flow of fluid within the channel. In another example, at least one curved section of the first channel has an internal cross-sectional geometry that varies along at least a portion of the length of the curved section. Therefore, the cross-sectional geometry of the first channel can vary along at least a portion of its length.

[0018] By varying the radius of curvature and / or cross-sectional geometry along at least a portion of the length of the bend, the problem of stagnant volume in the channel can be reduced, steady-state flow can be achieved more quickly, back pressure can be lower, and the risk of stagnation zones in the channel is reduced. Furthermore, compared to conventional valve blocks with drilled right-angle bends, lower pressure drops before and after the bend can be achieved, and smoother flow can be achieved. At a solution flow rate of 2000-2400 L / h through the channel, the pressure drop before and after a bend with a radius of curvature and / or cross-sectional geometry varying along at least a portion of the length of the bend can be reduced by at least 20% compared to a corresponding substantially 90° bend with a constant internal cross-sectional geometry and / or radius of curvature.

[0019] The inner diameter of the first channel can be between 2 mm and 21 mm. This diameter is preferably greater than 6 mm. In some examples, the inner diameter of the first channel is any of 3 mm, 6 mm, 10 mm, 14 mm, and 20.4 mm.

[0020] In addition to reducing back pressure, the lower stagnation volume in the valve block also provides for a reduction in the biological load therein (e.g., captured biocontaminants). Improved, substantially smooth fluid flow (e.g., over an increased pressure operating range) can also be designed into solution management systems, etc., incorporating such valve blocks (e.g., provided between inlet pipes / channels and solution outlet pipes / channels), which themselves may also include multiple components fluidly connected by corresponding bends / pipes / channels / channels.

[0021] According to one example of this disclosure, each valve section includes a recess having a sealing surface configured to receive and abut against a valve element shaped like a diaphragm or sheet. Thus, the valve sections in a valve block can form part of a diaphragm valve. The valve sections of the valve block may also include two or more ports connected to a passage within the valve block, and a valve seat located between the ports. The valve closes when the diaphragm or sheet is pressed against the valve seat. Movement of the diaphragm or sheet to open or close the valve can be controlled by means of an actuator. The actuator can be mechanical, pneumatic, hydraulic, or electric. Alternatively, the actuator can be manually actuated.

[0022] According to one example of this disclosure, a valve block has six sides and includes at least one integrally formed hose connector portion protruding from the valve block and connected to at least one inlet port or at least one outlet port; wherein the at least one hose connector portion extends longitudinally at an angle relative to the side of the valve block on which the at least one hose connector portion is disposed, and the angle is in the range of 30 degrees to 85 degrees. Therefore, the hose connector portion is inclined or tilted relative to the side of the valve block on which the hose connector portion is disposed. The hose connector portion is configured to connect to a hose, which in turn connects to a fluid source for supplying fluid to the system or a fluid receiver for receiving fluid from the system. The hose connector portion is an integral part of the valve block. The hose connector portion is coaxially arranged relative to at least one inlet port or at least one outlet port. Conventional valve blocks typically include or connect to a hose connector extending from a vertically arranged side perpendicular to the valve block. This can lead to hose kinking problems, which will impede flow. The force exerted on the hose connector by the weight of the hose can also damage the hose connector. By tilting the hose connector portion, the load on the hose connector portion is reduced, and the risk of hose kinking is decreased. The hose connector portion according to this disclosure will also allow for a more space-efficient arrangement of the connected hose, as it will extend closer to the valve block. This will also reduce the risk of an operator stepping on the hose and thus applying an external load to the hose connector portion, which could ultimately damage it. Further details regarding the hose connector portion will be described below with respect to a second aspect of this disclosure.

[0023] According to a first aspect of this disclosure, a solution management system for biological treatment is also provided. The system includes a valve block as disclosed above. It should be understood that all effects and advantages associated with the valve block according to the first aspect also apply to the solution management system of the first aspect.

[0024] In one example, the system further includes an actuator assembly having at least one actuator and a valve element connected to the at least one actuator. In another example, the system further includes an actuator assembly having at least four actuators and a valve element connected to each actuator, wherein a valve block is connected to the actuator assembly such that the valve element is aligned with a valve section of the valve block and seals the valve section of the valve block between the valve block and the actuator. As discussed above, the valve element may be a diaphragm or a membrane and is arranged between the respective actuator and the valve block. The actuator is configured to move the central portion of the respective valve element toward or away from the valve section of the valve block to close or open the valve. Each valve can be closed by pressing the central portion of the valve element against the valve section of the valve block such that it abuts against the valve seat of the valve section. In this way, no fluid will be able to pass between the two ports of the valve section. Each valve can be opened by releasing the pressure / force on the valve element so that the valve element does not abut against the valve seat of the valve section in the valve block. The system can be configured such that all valves are closed by default. To understand, the system may include multiple valve blocks and corresponding actuator assemblies.

[0025] The actuator assembly may also include at least one actuator clamp holding at least one actuator, the actuator assembly being mounted in the system by connecting at least one actuator clamp to a support structure of the system. The actuator clamp may be configured to clamp at least two actuators together, thereby mounting at least two actuators in the system by connecting at least one actuator clamp to the support structure of the system. The system typically includes a support structure, such as a frame, beam, column, or the like, for connecting various components. The actuator clamp facilitates the simultaneous manipulation of multiple actuators and thus enables the simple mounting of several actuators in the system. The support structure may include at least one recess, slot, or orifice configured to receive a corresponding protrusion on the actuator clamp, thereby connecting the actuator assembly in the system. In one example, the support structure includes an upper column and a lower column, wherein the actuator clamp is arranged between these columns and engages with both columns. The actuator clamp, and therefore the actuator assembly, may be connected to the support structure, allowing lateral movement of the actuator assembly. This facilitates the mounting of the actuator assembly and the connection of the valve block due to increased tolerances.

[0026] The valve block can be attached to the actuator by means of fasteners. Fasteners are suitably bolts or screws. During system assembly, the actuators of each actuator assembly are first clamped together using at least one actuator clamp. The actuator assemblies are then installed by connecting the actuator clamps to the system's support structure. Subsequently, the valve block is aligned with the actuator assembly and attached to the actuator by means of fasteners. The valve block is arranged with at least one side facing outwards, away from the system, and therefore easily accessible from outside the system. This method of connecting and installing different components in the system also improves and facilitates manipulation during maintenance compared to conventional solutions. In solution management systems used for biological processes, valve elements are typically replaced annually, or they may have experienced excessive wear and therefore require replacement. For systems as disclosed herein, the valve element can be accessed by disconnecting (unscrewing) from the corresponding actuator and removing the entire valve block. Since the actuator assembly is connected to the support structure via the actuator clamp, the valve block can be removed without affecting the stability of the actuator assembly. Molded or printed valve blocks may also be relatively lightweight and therefore easy to remove from the system. In traditional systems, the valve element is accessed by removing the actuator. This is more cumbersome because the actuator is typically located inside the valve block and is therefore not as easily accessible as the valve block itself. Furthermore, the actuator can be very heavy, potentially complicating maintenance. As mentioned above, the valve may be closed by default. This means the valve element is pressed against the valve seat in the valve section by the actuator by default. In this case, to remove the valve block during maintenance, the actuator must first be controlled to release the pressure on the valve element before unscrewing the valve block from the actuator. If the valve is open by default, the valve block can be unscrewed directly.

[0027] According to a second aspect of this disclosure, a valve block is provided for controlling the flow of fluid into or out of a solution management system for biological treatment. The valve block is a single unit having six sides and includes: at least one inlet port disposed on any side of the valve block; at least one outlet port disposed on any side of the valve block; at least one valve section fluidly connected to the at least one inlet port and the at least one outlet port, the valve section being configured to receive a valve element for controlling the flow of fluid through the valve block; and at least one integrally formed hose connector portion projecting from the valve block and connected to the at least one inlet port or the at least one outlet port; wherein the at least one hose connector portion extends longitudinally at an angle relative to the side of the valve block on which the at least one hose connector portion is disposed, wherein the angle is in the range of 30 degrees to 85 degrees. The angle between the hose connector portion and the side of the valve block on which the hose connector portion is disposed may be referred to as an inclination angle. A valve block having this inclination hose connector portion has been described above in conjunction with a first aspect of this disclosure. However, it should be understood that a valve block according to the invention may also include the inclination hose connector portion without including a first channel.

[0028] The hose connector portion is configured to connect to a hose, which in turn connects to a fluid source for supplying fluid to the system or a fluid receiver for receiving fluid from the system. The hose connector portion is arranged coaxially with respect to at least one inlet port or at least one outlet port. As mentioned above, the angled hose connector portion reduces the load on the hose connector portion and also reduces the risk of hose kinking. The hose connector portion according to this disclosure also allows for a more space-efficient arrangement of the connected hose, as it extends closer to the valve block. This also reduces the risk of an operator stepping on the hose and thus applying an external load to the hose connector portion (which could ultimately damage the hose connector portion). Furthermore, in the event of someone stepping on the hose connected to the angled hose connector portion, the stress on the angled hose connector portion will be significantly reduced compared to a straight hose connector portion. Having an integrally formed hose connector portion, rather than a separate hose connector portion attached to the valve block, also reduces the number of joints or couplings, which will reduce the risk of leakage.

[0029] The angle between the hose connector portion and the side on which it is disposed can be between 40 and 65 degrees. If the angle is too small, the hose connector portion may obstruct the fasteners used to connect the valve block to the actuator. Therefore, the angle should be at least 30 degrees, preferably at least 35 degrees, and more preferably at least 40 degrees. If the angle is too large, it increases the risk of hose kinking and hose connector breakage. Therefore, the angle should not exceed 85 degrees, preferably not exceed 75 degrees, and more preferably not exceed 65 degrees.

[0030] At least one hose connector portion may extend in a downward or upward direction. When the valve block is arranged with its outermost portion substantially vertical, the hose connector portion may be arranged to slope downward or upward. When the hose is connected to the valve block from below, a downward slope may be advantageous. The weight and gravity of the hose will cause it to fall towards the ground, and therefore the load on the hose connector portion will be in the downward direction. A downward slope on the hose connector portion will thus reduce the risk of hose kinking and hose connector breakage. When the hose is connected to the valve block from above, the hose connector portion is suitably sloped upward to reduce the load on the hose connector portion and reduce the risk of hose kinking. It should be understood that the hose connector portion may be sloped laterally or in any direction, with the angle between 30 degrees and 85 degrees.

[0031] The valve block includes a third channel extending from at least one inlet port or at least one outlet port where the hose connector portion is located. This third channel may be inclined at an angle similar to the inclination angle of the hose connector portion. This improves fluid flow into or out of the valve block. At least the portion of the third channel closest to the inlet or outlet port may be inclined at an angle similar to the inclination angle of the hose connector portion. When the hose connector portion is arranged at at least one outlet port and inclined downwards, and the third channel is therefore inclined downwards, system drainage is improved.

[0032] The inner diameter of the hose connector portion can range from 2 mm to 21 mm. This inner diameter is preferably greater than 6 mm. In some examples, the inner diameter of the hose connector portion is any of 3 mm, 6 mm, 10 mm, 14 mm, and 20.4 mm. With a smaller inner diameter in the hose connector portion, the hose will have a similarly small inner diameter, and such a hose is less prone to kinking. Therefore, a hose connector portion with a smaller inner diameter can be arranged with a larger tilt angle (less tilt). However, a hose connector portion with a smaller inner diameter will be more prone to breakage due to the load applied by the connected hose or any external load. Therefore, the inner diameter of the hose connector portion should be considered when determining the tilt angle of the hose connection portion. Furthermore, the vertical position of the hose connector portion on the valve block can also affect the tilt angle. For example, the valve block may include two hose connector portions with the same inner diameter, one arranged above the other. If the connected hose falls downwards towards the ground, the load on the upper hose connector portion (farthest from the ground) will be higher than the load on the lower hose connector portion (closest to the ground). Therefore, the upper hose connector section can be arranged such that the tilt angle is smaller than that of the lower hose connector section (more tilted).

[0033] Therefore, the valve block may include at least two hose connector portions, which extend longitudinally at different angles relative to the respective sides of the valve block on which the at least two hose connector portions are disposed.

[0034] At least one valve section may include a recess with a sealing surface configured to receive and abut a valve element in the shape of a diaphragm or diaphragm.

[0035] The valve block may include four or more valve sections fluidly connected to at least one inlet port and at least one outlet port, each valve section configured to receive a valve element for controlling fluid passing through the valve block; wherein at least two valve sections are fluidly connected by means of an integrally formed first channel that is directional two or more times. The features, details, and advantages relating to the valve sections and first channel as described with respect to the first aspect of this disclosure also apply to the second aspect of this disclosure.

[0036] According to a second aspect of this disclosure, a solution management system for biological treatment is also provided. The system includes a valve block according to the second aspect of this disclosure.

[0037] The system according to the second aspect may further include: an actuator assembly having at least one actuator; and a valve element connected to each actuator; wherein a valve block is connected to the actuator assembly such that the valve element is aligned with a valve section of the valve block and seals the valve section of the valve block between the valve block and the actuator. The system may include a valve block having any number of valve sections and corresponding valve elements and actuators.

[0038] The system according to the second aspect may also include at least one actuator clamp that clamps at least two actuators together, and the actuator assembly is mounted in the system by connecting at least one actuator clamp to the support structure of the system.

[0039] According to the second aspect, the valve block can be attached to the actuator by means of fasteners.

[0040] The system according to the second aspect may also include a hose connected to at least one hose connector portion.

[0041] It should be understood that all the effects and advantages associated with the valve block according to the second aspect also apply to the solution management system of the second aspect. Furthermore, the features and details associated with a solution management system for biological treatment that includes a valve block according to the first aspect of this disclosure also apply to a solution management system for biological treatment that includes a valve block according to the second aspect of this disclosure.

[0042] This disclosure will become clearer from the following detailed description. The detailed description and specific examples disclose preferred embodiments of this disclosure by way of example only. Based on the guidance of this detailed description, those skilled in the art will understand that changes and modifications can be made within the scope of the appended claims. Attached Figure Description

[0043] The foregoing objects, additional objects, features, and advantages of this disclosure will be more fully understood by referring to the following illustrative and non-limiting detailed description of exemplary embodiments of the present disclosure (when taken in conjunction with the accompanying drawings), wherein: Figure 1a -b schematically illustrates a valve block for controlling the flow of fluid into or out of a solution management system for biological treatment, according to an example of this disclosure; Figure 2 A valve block for controlling the flow of fluid into or out of a solution management system for biological treatment, according to an example of this disclosure, is schematically shown. Figure 3 Details of a valve block according to an example of this disclosure are schematically shown; Figure 4 Details of a valve block according to an example of this disclosure are schematically shown; Figure 5a -b schematically illustrates a valve block for controlling the flow of fluid into or out of a solution management system for biological treatment, according to an example of this disclosure; Figure 6 A valve block for controlling the flow of fluid into or out of a solution management system for biological treatment, according to an example of this disclosure, is shown. Figure 7a -b illustrates details of a solution management system for biological treatment according to an example of this disclosure; and Figure 8a -b illustrates a solution management system for biological treatment according to an example of this disclosure. Detailed Implementation

[0044] This disclosure will now be described with reference to the accompanying drawings, which illustrate preferred exemplary embodiments of the present disclosure. However, this disclosure may be embodied in other forms and should not be construed as limited to the embodiments disclosed herein. The disclosed embodiments are provided only to fully convey the scope of this disclosure to those skilled in the art.

[0045] It should be understood that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting. It should be noted that, as in the specification and appended claims, the articles “a,” “an,” “the,” and “the” are intended to indicate the presence of one or more elements unless the context clearly indicates otherwise. Thus, for example, the reference to “a unit” or “the unit” may include several means, etc. Furthermore, the terms “comprising,” “including,” “containing,” and similar wording are intended as open-ended transitional terms that do indeed exclude the possibility of the presence of additional elements or steps.

[0046] Figure 1a -b schematically illustrates a valve block 100 for controlling the flow of fluid into or out of a solution management system for biological treatment, according to an example of this disclosure. Figure 1a A portion of the front side of valve block 100 is shown. Figure 1bThis is a side view of valve block 100. Valve block 100 is a single unit and is therefore manufactured as a single piece. The valve block includes: at least one inlet port 10; at least one outlet port 20; and four or more valve sections 30 fluidly connected to the at least one inlet port 10 and the at least one outlet port 20. In this example, valve block 100 shows two inlet ports 10 and three outlet ports 20. Only one valve section 30 is shown, but valve block 100 in this example includes five valve sections 30. Each valve section 30 is configured to receive a valve element (not shown) for controlling the fluid passing through valve block 100. At least two valve sections 30 are fluidly connected by means of an integrally formed first channel 40, which changes direction two or more times.

[0047] The first channel 40 may have a substantially constant cross-sectional area. Therefore, even when changing direction, the cross-sectional area of ​​the first channel 40 may remain substantially the same along its extension.

[0048] Figure 1a The valve section 30 is shown, which includes a recess 34 having a sealing surface 36 configured to receive and abut against a valve element (see [link]). Figure 7a The valve section 30 of the valve block 100 also includes two or more ports 31 connected to channels within the valve block 100, and valve seats 33 located between the ports 31.

[0049] The valve block 100 can be manufactured by additive manufacturing or by molding or casting.

[0050] Figure 2 A valve block 100 for controlling the flow of fluid into or out of a solution management system for biological treatment, according to an example of this disclosure, is schematically shown. The valve block 100 can be as follows: Figure 1a The configuration is disclosed in -b. Figure 2 A cross-sectional view from the front of the valve block 100 is shown, and in this example, the valve block includes eight valve sections 30.

[0051] In this example, the first channel 40 is arranged to fluidly connect two diagonally arranged valve sections 30 in the valve block 100. In addition, the first channel 40 fluidly connects adjacent valve sections 30, such that the five valve sections 30 are directly connected by means of the first channel 40.

[0052] The first channel 40 includes at least two curved sections 44 that change the orientation of the first channel 40 at least twice. In this example, the curved sections 44 are configured to provide a substantially 90-degree change of orientation. The first channel 40 is defined by a channel wall 42 having a thickness between 1.6 mm and 5 mm. The thickness of the channel wall 42 of the first channel may vary along the extension of the first channel 40. The channel wall 42 extends continuously along the longitudinal direction of the first channel 40. The inner diameter D of the first channel 40 may be between 2 mm and 21 mm. The inner diameter D is preferably greater than 6 mm. When the first channel 40 has a non-circular cross-sectional shape, the first channel 40 will have a shape and / or size corresponding to the inner diameter between 2 mm and 21 mm.

[0053] The valve block 100 may also include a second channel 50. The second channel 50 may be configured similarly to the first channel 40 and thus may change direction two or more times. Alternatively, the second channel 50 may be configured differently from the first channel 40. In an example not shown in the figures, the first channel 40 and the second channel 50 extend in different planes within the valve block 100 and pass over each other without intersecting.

[0054] Figure 3 Details of a valve block 100 according to an example of this disclosure are schematically shown. The valve block 100 can be configured as disclosed in Figures 1-2. In this example, at least one curved segment 44 of the first channel 40 is configured such that the radius of curvature R varies along at least a portion of the length of the curved segment 44. This is in Figure 3 As shown, the radius R1 at the first position of the curved section 44 differs from the radius R2 at the second position and the radius R3 at the third position of the curved section 44. The radius of curvature R of at least one curved section 44 can vary while maintaining a constant cross-sectional area A of the first channel 40. This avoids sharp bends or angles and allows for continuous flow of fluid within the channel.

[0055] Figure 4 Details of a valve block 100 according to an example of this disclosure are schematically shown. In this example, at least one curved section 44 of the first channel 40 has an internal cross-sectional geometry that varies along at least a portion of the length of the curved section 44. Therefore, the first channel 40 may have a cross-sectional geometry that varies along at least a portion of the length of the first channel 40. The first channel 40 may have a certain cross-sectional geometry in substantially straight sections of the first channel 40 and another cross-sectional geometry in the curved section 44. The cross-sectional geometry can vary while maintaining a constant cross-sectional area A in the curved section 44. Furthermore, smoother flow, reduced pressure drop, etc., can be achieved by providing variable cross-sectional geometry and / or variable curvature for one or more fluid channels.

[0056] Figure 5a -b schematically illustrates a valve block 100 for controlling fluid flow into and / or out of a solution management system for biological treatment, according to an example of this disclosure. The valve block 100 is a single unit having six sides 110 and includes: at least one inlet port 10 disposed on any side 110 of the valve block 100; at least one outlet port 20 disposed on any side 110 of the valve block 100; and at least one valve section 30 fluidly connected to the at least one inlet port 10 and the at least one outlet port 20, the valve section 30 being configured to receive a valve element (see [link to documentation]). Figure 7a The valve block 100 is used to control the fluid passing through it. The valve block 100 also includes at least one integrally formed hose connector portion 60 that protrudes from the valve block 100 and is connected to at least one inlet port 10 or at least one outlet port 20, wherein at least one hose connector portion 60 extends longitudinally at an angle α relative to a side 110 of the valve block 100 on which the hose connector portion 60 is disposed, wherein the angle α is in the range of 30 degrees to 85 degrees.

[0057] The angle α between the hose connector portion 60 and the side 110 of the valve block 100 on which the hose connector portion 60 is disposed may be referred to as the tilt angle, and the hose connector portion 60 disposed at this angle α may be referred to as the tilted hose connector portion 60. The valve block 100 may also include a hose connector portion 70 that extends substantially perpendicularly to the side 110 of the valve block 100 on which the hose connector portion 70 is disposed. This hose connector portion 70 may be referred to as the straight hose connector portion 70. The figure shows two tilted hose connector portions 60 and one straight hose connector portion 70, but the valve block 100 may include any number of hose connector portions 60 and 70.

[0058] The tilting hose connector portion 60 is configured to connect to a hose, which in turn connects to a fluid source for supplying fluid to the system or a fluid receiver for receiving fluid from the system. The hose connector portion 60 is arranged coaxially with respect to at least one inlet port 10 or at least one outlet port 20. The tilting hose connector portion 60 reduces the load on the hose connector portion 60 and reduces the risk of hose kinking.

[0059] The angle α between the hose connector portion 60 and the side 110 on which the hose connector portion 60 is disposed can be between 40 and 65 degrees. If the angle α is too small, the hose connector portion 60 may obstruct the fasteners used to attach the valve block 100 to the system. Therefore, the angle α should be at least 30 degrees, preferably at least 35 degrees, and more preferably at least 40 degrees. If the angle α is too large, the risk of hose kinking and breakage of the hose connector portion 60 increases. Therefore, the angle α should not exceed 85 degrees, preferably not exceed 75 degrees, and more preferably not exceed 65 degrees.

[0060] Figure 5a The display shows the hose connector portion 60 tilted downwards, and Figure 5b The hose connector portion 60 is shown tilted upwards. However, it should be understood that the hose connector portion 60 can be tilted to the side or in any direction, with an angle between 30 and 85 degrees.

[0061] Figure 6 A valve block 100 for controlling the flow of fluid into or out of a solution management system for biological treatment, according to an example of this disclosure, is schematically shown. The valve block 100 can be as follows: Figure 5a or Figure 5b The configuration is disclosed herein. The valve block 100 also includes at least two valve sections 30 fluidly connected by an integrally formed first channel 40, which changes direction two or more times. The first channel 40 may have a substantially constant cross-sectional area. Therefore, even when changing direction, the cross-sectional area of ​​the first channel 40 may remain substantially the same along its extension.

[0062] The valve block 100 can be manufactured by additive manufacturing or by molding or casting.

[0063] Figure 6 The inner diameter HCd of the hose connector portion 60 is also shown, which can be between 2 mm and 21 mm. The inner diameter HCd is preferably greater than 6 mm. The inner diameter HCd can vary along the longitudinal extension of the hose connector portion 60. The valve block 100 in this example also includes a third channel 55 extending from at least one outlet port 20 where the hose connector portion 60 is located. This third channel 55 can be inclined at an angle similar to the inclination angle α of the hose connector portion 60. This improves the fluid flow leaving the valve block 100 and thus improves drainage. The third channel 55 can be inclined at an angle different from the inclination angle α of the hose connector portion 60. As an example, the third channel 55 can be inclined downwards, preferably less than the inclination of the hose connector portion 60.

[0064] Each valve section 30 includes a recess 34 having a sealing surface 36 configured to receive and abut against a valve element in the shape of a diaphragm or diaphragm (see [link]). Figure 7a The valve section 30 of the valve block 100 also includes two or more ports 31 connected to channels within the valve block 100, and valve seats 33 located between the ports 31.

[0065] Figure 7a -b illustrates details of a solution management system 200 for biological treatment according to an example of this disclosure. The system 200 includes a valve block 100 as disclosed in any of Figures 1-6. It should be understood that even if the valve block 100 in these figures includes an inclined hose connector portion 60, the valve block 100 may also include a straight hose connector portion 60, or may not include a hose connector portion 60 at all.

[0066] System 200 also includes actuator assembly 300 having at least one actuator 310 and a valve element 32 connected to the at least one actuator 310. The number of actuators 310 and valve elements 32 in each actuator assembly 300 may depend on the number of valve sections 30 of valve block 100. In these figures, only two actuators 310 are shown for clarity. Figure 7a An exploded view of the components of system 200 is displayed, and Figure 7b The same components are shown in an assembled and connected state. Valve block 100 is connected to actuator assembly 300 such that valve element 32 is aligned with and seals valve section 30 of valve block 100. Therefore, valve element 32 is arranged between valve block 100 and actuator 310. Valve element 32 may be a diaphragm or a membrane and is arranged between the corresponding actuator 310 and valve block 100. In the assembled state, valve element 32 is arranged in the recess 34 of valve section 30 and abuts against sealing surface 36. Actuator 310 is controlled to move the central portion of the corresponding valve element 32 toward or away from valve section 30 of valve block 100 to close or open the valve. To close the valve, the central portion of valve element 32 presses against valve section 30 of valve block 100 such that it abuts against valve seat 33 of valve section 30. Thus, no fluid will be able to pass between the two ports 31 of valve section 30. To open the valve and release pressure, valve element 32 must not abut against valve seat 33 of valve section 30. System 200 can be configured to close all valves of valve block 100 by default.

[0067] Actuator assembly 300 may further include at least one actuator clamp 320 that holds at least one actuator 310. In this figure, actuator clamp 320 clamps at least two actuators 310 together. Actuator assembly 300 is mounted in system 200 by connecting at least one actuator clamp 320 to a support structure (not shown) of system 200. Actuator clamp 320 facilitates the simultaneous manipulation of several actuators 310 and thus allows for the simple mounting of multiple actuators 310 in system 200. Actuator clamp 320 and actuator assembly 300 may be connected to the support structure such that it allows lateral movement of actuator assembly 300. This facilitates the mounting of actuator assembly 300 and connection of valve block 100, as this increases tolerances.

[0068] When assembling system 200, the actuators 310 of each actuator assembly 300 are first clamped together using at least one actuator clamp 320. Then, the actuator assemblies 300 are installed by connecting the actuator clamps 320 to the support structure of system 200. Subsequently, the valve block 100 is aligned with the actuator assembly 300 and connected to the actuator 310. The valve block 100 can be connected to the actuator using fasteners 330, such as... Figure 7a As shown in the figures, the fastener 330 is suitably a bolt or screw. The valve block 100 is arranged with at least one side facing outwards, away from the system 200, and is therefore easily accessible from outside the system 200. For the system 200 disclosed in these figures, the valve element 32 can be accessed by disconnecting (unscrewing) the entire valve block 100 from the corresponding actuator 310 and removing it. Since the actuator assembly 300 is connected to the support structure via the actuator clamp 320, the valve block 100 can be removed without affecting the stability of the actuator assembly 300. Therefore, significant time savings can be achieved during maintenance / repair, especially when the system 200 contains many such easily removable valve blocks 100 (e.g., in one practical embodiment, the system contains ten such valve blocks of different sizes). In an experimental test example, it was found by a maintenance engineer that when such valve blocks (rather than removing the actuator) were removed, the maintenance time for each valve block was reduced from 45 minutes to 15 minutes.

[0069] Figure 8a -b illustrates an example of a solution management system 200 for biological treatment according to this disclosure. The system 200 includes at least one valve block 100 as disclosed in any one of Figures 1-6, and as shown in Figures 1-6. Figure 7aThe corresponding actuator assembly 300 disclosed in -b. In these examples, system 200 includes five valve blocks 100, with two, four, or six inlet ports 10 / outlet ports 20 facing outwards. It should be understood that the inlet ports 10 and outlet ports 20 shown in the figures are merely examples, and an inlet port 10 can be an outlet port 20, and vice versa. Figure 8a In this system 200, there is a housing 201 that encloses other components of the system 200.

[0070] Different solutions enter the system 200 through the inlet port 10 of the valve block 100. These solutions can be, for example, different buffer solutions, water, acids, salts, bases, additives, etc. The system 200 may include, for example, at least one buffer solution inlet, one water inlet, one base inlet, one acid inlet, and one additive inlet. A valve formed by the valve block 100 and the actuator assembly 300 controls the flow of solutions into / out of the system 200. One or more pumps 204 are arranged to draw fluid from the inlet port 10 through the valve block 100 and then pump the drawn fluid through a pump outlet pipe / channel into the system 200 to create fluid displacement within the pipe / channel. The system 200 may include at least one mixing region (not shown) for mixing the solutions from the inlet port 10. This at least one mixing region may be, for example, a static mixer or a mixing connector, such as a T-connector or a Y-connector.

[0071] Solution characteristic unit 207 is arranged in fluid communication with the mixer region. Solution characteristic unit 207 includes one or more solution characteristic sensors (not shown) configured to sense one or more solution characteristic values ​​of the mixed solution. The one or more solution characteristic sensors may be, for example, one or more pH sensors, one or more conductivity sensors, and / or one or more optical sensors (such as UV sensors). System 200 may also include one or more flow sensors and / or one or more pressure sensors and / or one or more temperature sensors. Based on the solution characteristics detected by the one or more solution characteristic sensors, the characteristic values ​​of the mixed solution may be recorded in solution characteristic unit 207. Solution characteristic unit 207 may include a processor for receiving these measurements, processing these values, and generating a solution characteristic signal indicative of the sensed values. For example, such a solution characteristic signal may be generated if the solution characteristic value deviates from the expected value of a particular solution being produced by the system. The solution characteristic signal may include information about the degree of deviation between the characteristic value and the expected value. A signal may be issued or not issued if the characteristic value is equal to or within a predetermined deviation range from the expected value. The solution characteristics unit / processor can be arranged to communicate with a valve connected to inlet port 10 for buffer / base / acid / salt / water / additive, and / or with pump 204 to increase / decrease / stop the addition of, for example, base to the mixed solution. The processor can be arranged / built into the system, or (wirelessly) connected to the system and arranged externally / at a distance from the system. The measured characteristics can be visualized on a monitor (wirelessly) connected to the processor. The monitor can be accessed from outside the system, or arranged externally / at a distance from the system.

[0072] System 200 includes at least one outlet port 20 fluidly connected to a solution characterization unit. The outlet port 20 is arranged to discharge a mixed solution from the solution management system 200. The outlet port 20 may be connected to a solution storage container. Alternatively, the solution management system 200 may be directly connected to, for example, a chromatography system (not shown) via the outlet port 20. In yet another alternative, the solution management system 200 may be integrated into, for example, a chromatography system (not shown).

[0073] Those skilled in the art will understand that this disclosure is not limited to the embodiments described above. For example, various types of easily releasable mechanisms can be provided to enable the rapid release and engagement of valve block 100 in system 200. Those skilled in the art will also understand that modifications and variations are possible within the scope of the appended claims.

Claims

1. A valve block (100) for controlling fluid flow into and / or out of a solution management system (200) for biological treatment, said valve block (100) being a single unit and comprising: -At least one inlet port (10); -At least one exit port (20); as well as - Four or more valve sections (30) fluidly connected to the at least one inlet port (10) and the at least one outlet port (20), each valve section (30) configured to receive a valve element (32) for controlling the fluid passing through the valve block (100). In this configuration, at least two valve sections (30) are fluidly connected to each other by means of an integrally formed first channel (40), which changes direction two or more times.

2. The valve block (100) according to claim 1, wherein, The first channel (40) has a substantially constant cross-sectional area.

3. The valve block (100) according to claim 1 or 2, wherein, The at least two valve sections (30) that are fluidly connected are arranged diagonally in the valve block (100).

4. The valve block (100) according to any one of the preceding claims, wherein, The four or more valve sections (30) are all fluidly connected to each other.

5. The valve block (100) according to any one of the preceding claims, wherein, The first channel (40) is defined by a channel wall (42) having a thickness between 1.6 mm and 5 mm.

6. The valve block (100) according to claim 5, wherein, The channel wall (42) of the first channel (40) extends continuously along the longitudinal direction of the first channel (40).

7. The valve block (100) according to any one of the preceding claims further includes a second channel (50), wherein the first channel (40) and the second channel (50) extend in different planes within the valve block (100) and pass through each other without intersecting.

8. The valve block (100) according to any one of the preceding claims, wherein, The first channel (40) includes at least two curved sections (44) that change the orientation of the first channel (40) at least twice, wherein at least one curved section (44) is configured such that the radius of curvature (R) varies along at least a portion of the length of the curved section (44).

9. The valve block (100) according to claim 8, wherein, At least one curved segment (44) of the first channel (40) has an internal cross-sectional geometry that varies along at least a portion of the length (CL) of the curved segment (44).

10. The valve block (100) according to any one of the preceding claims, wherein, Each valve section (30) includes a recess (34) having a sealing surface (36) configured to receive and abut a valve element (32) in the shape of a diaphragm or diaphragm.

11. The valve block (100) according to any one of the preceding claims, wherein, The valve block (100) has six sides (110) and also includes: - At least one integrally formed hose connector portion (60) protrudes from the valve block (100) and is connected to the at least one inlet port (10) or the at least one outlet port (20); The at least one hose connector portion (60) extends longitudinally at an angle (α) relative to the side (110) of the valve block (100) on which the at least one hose connector portion (60) is disposed, wherein the angle (α) is in the range of 30 degrees to 85 degrees.

12. A solution management system (200) for biological treatment, the system (200) comprising at least one valve block (100) according to any one of claims 1 to 11.

13. The system (200) according to claim 12, further comprising: - An actuator assembly (300) having at least four actuators (310). as well as - Valve element (32) connected to each actuator (310); The valve block (100) is connected to the actuator assembly (300) such that the valve element (32) is aligned with the valve section (30) of the valve block (100) and seals the valve section (30) of the valve block (100) between the valve block (100) and the actuator (310).

14. The system (200) according to claim 13, wherein, The actuator assembly (300) further includes at least one actuator clamp (320) that holds at least one actuator (310), and the actuator assembly (300) is mounted in the system (200) by connecting the at least one actuator clamp (320) to a support structure (210) of the system (200).

15. The system (200) according to claim 13 or 14, wherein, The valve block (100) is attached to the actuator (310) by means of fasteners (330).

16. A valve block (100) for controlling the flow of fluid into and / or out of a solution management system (200) for biological treatment, said valve block (100) being a single unit having six sides (110) and comprising: - At least one inlet port (10) is arranged on any side (110) of the valve block (100); - At least one outlet port (20) is arranged on any side (110) of the valve block (100); - At least one valve section (30) fluidly connected to the at least one inlet port (10) and the at least one outlet port (20), the valve section (30) being configured to receive a valve element (32) for controlling fluid through the valve block (100); and - At least one integrally formed hose connector portion (60) protrudes from the valve block (100) and is connected to the at least one inlet port (10) or the at least one outlet port (20); The at least one hose connector portion (60) extends longitudinally at an angle (α) relative to the side (110) of the valve block (100) on which the at least one hose connector portion (60) is disposed, wherein the angle (α) is in the range of 30 degrees to 85 degrees.

17. The valve block (100) according to claim 16, wherein, The angle (α) is in the range of 40 degrees to 65 degrees.

18. The valve block (100) according to claim 16 or 17, wherein, The at least one hose connector portion (60) extends in a downward or upward direction.

19. The valve block (100) according to any one of claims 16 to 18, wherein, The valve block (100) includes at least two hose connector portions (60) that extend longitudinally at different angles (α) relative to the respective sides (110) of the valve block (100) on which the at least two hose connector portions (60) are arranged.

20. The valve block (100) according to any one of claims 16 to 19, wherein, The at least one valve section (30) includes a recess (34) having a sealing surface (36) configured to receive and abut against a valve element (32) in the shape of a diaphragm or diaphragm.

21. The valve block (100) according to any one of claims 16 to 20, comprising four or more valve sections (30) fluidly connected to the at least one inlet port (10) and the at least one outlet port (30), each valve section (30) configured to receive a valve element (32) for controlling fluid through the valve block (100); wherein, At least two valve sections (30) are fluidly connected by means of an integrally formed first channel (40), which changes direction two or more times.

22. A solution management system (200) for biological treatment, the system (200) comprising at least one valve block (100) according to any one of claims 16 to 21.

23. The system (200) according to claim 22, further comprising: - An actuator assembly (300) having at least one actuator (310). as well as - At least one valve element connected to each actuator (310); The valve block (100) is connected to the actuator assembly (300) such that the valve element (32) is aligned with the valve section (30) of the valve block (100) and seals the valve section (30) of the valve block (100) between the valve block (100) and the actuator (310).

24. The system (200) of claim 23, wherein the actuator assembly (300) further comprises at least one actuator clamp (320) holding at least one actuator (310), the actuator assembly (300) being mounted in the system (200) by connecting the at least one actuator clamp (320) to a support structure (210) of the system (200).

25. The system (200) according to claim 24, wherein, The valve block (100) is attached to the actuator (310) by means of fasteners (330).

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