Salt hydrolysis reaction device for preparing heparin sodium

Abstract

The utility model discloses a heparin sodium preparation salt hydrolysis reaction device, which relates to the heparin sodium preparation salt hydrolysis reaction field, and comprises a bottom plate, the upper end of the bottom plate is fixedly connected with a support rod, the upper end of the support rod is fixedly connected with a reaction barrel, and the upper end of the reaction barrel is fixedly connected with a crushing barrel; the upper end of the crushing barrel is fixedly connected with a driving assembly, the upper end of the crushing barrel is fixedly connected with a first feeding opening, the interior of the reaction barrel is fixedly connected with a partition plate, a stirring assembly is arranged at the position, located in the reaction barrel, of the lower end of the crushing barrel, and a crushing assembly is arranged in the crushing barrel. By the adoption of the structure, the driving assembly is started to enable the first driving gear to drive the crushing gear to rotate, so that the crushing gear rotates to enable the crushing rod to rotate and then drive the crushing piece to rotate, and the intestinal mucosa can be crushed under the action of the crushing piece.

Description

Technical Field

[0001] The utility model belongs to the field of sodium heparin preparation and salt hydrolysis reaction, in particular to a sodium heparin preparation and salt hydrolysis reaction device. Background Art

[0002] Heparin sodium is an anticoagulant that can interfere with many links of the blood coagulation process and has an anticoagulant effect both in vivo and in vitro. It is mainly found in the liver, lungs, and intestinal mucosa of mammals, and is often fused with proteins to form a complex. The salting process is to send the treated intestinal mucosal fluid into the salting tank and then add the salting agent, and then obtain the salting liquid and filter residue through heating, stirring, filtering and heat preservation.

[0003] According to a Chinese patent with the announcement number "CN218422772U", a salting device for extracting sodium heparin from intestinal mucosa is disclosed, which relates to the technical field of sodium heparin extraction and processing equipment, including a reactor, both sides of the bottom of the reactor are fixedly connected to a fixed base, the bottom inside the reactor is provided with a screen, one side of the top of the reactor is connected to a steam inlet, and the other side of the top of the reactor is connected to a steam outlet. The utility model is provided with a servo motor, a first pulley, a belt, a second pulley, a rotating rod, a first special-shaped gear, a second special-shaped gear, a first stirring rod and a second stirring rod. The operation of the servo motor drives the first stirring rod and the second stirring rod to rotate, so as to achieve the effect of double stirring of the intestinal mucosa and the salt solution inside the reactor, avoid the situation that the inefficiency of the intestinal mucosa during the extraction process due to low stirring efficiency, which is beneficial to improve the extraction rate of the intestinal mucosa, and at the same time, it is beneficial to improve the utilization rate of the device for extracting sodium heparin;

[0004] It can be seen from the above structure that by setting a servo motor, a first pulley, a belt, a second pulley, a rotating rod, a turntable, an L-shaped rod, a cleaning plate and a sieve, the servo motor drives the rotating rod to rotate, thereby driving the turntable and the L-shaped rod to rotate, so as to meet the effect of cleaning the sieve, avoid the situation where the casing mucosal fluid remains on the filter net and causes the extraction liquid discharge efficiency to slow down, which is beneficial to improving the working efficiency of the sieve to discharge the liquid, thereby helping to improve the working efficiency of the sodium heparin extraction device. However, it can be seen from the above figures and texts that in the existing technology, it is difficult to crush the intestinal mucosa at the same time, resulting in low production efficiency and full reaction efficiency, which makes the above device poor in practicality. Although the above device achieves a filtering effect, it is impossible to conveniently discharge the filtered impurities, which reduces its practicality. Utility Model Content

[0005] In view of the problems mentioned in the background technology, the purpose of the utility model is to provide a heparin sodium preparation salt hydrolysis reaction device to solve the above problems.

[0006] The above technical objectives of the utility model are achieved through the following technical solutions:

[0007] A sodium heparin preparation and salt hydrolysis reaction device comprises a bottom plate, the upper end of the bottom plate is fixedly connected to a support rod, the upper end of the support rod is fixedly connected to a reaction barrel, the upper end of the reaction barrel is fixedly connected to a crushing barrel, the upper end of the crushing barrel is fixedly connected to a driving component, the upper end of the crushing barrel is fixedly connected to a first feed port, the interior of the reaction barrel is fixedly connected to a partition plate, the lower end of the crushing barrel is located inside the reaction barrel and is provided with a stirring component, the interior of the crushing barrel is provided with a crushing component, the lower end of the interior of the reaction barrel is fixedly connected to a filtering component, the lower end of the reaction barrel is fixedly connected to a discharge pipe, the crushing component comprises a crushing gear arranged at the upper end of the crushing barrel, the crushing gear is rotatably connected to the upper end of the crushing barrel, and the lower ends of the crushing gears are fixedly connected There is a breaking rod, and the outer surface of the breaking rod is fixedly connected with a breaking piece, the breaking assembly and the driving assembly are meshed with each other, the driving assembly includes a driving motor arranged at the upper end of the breaking barrel, the output shaft of the driving motor passes through the breaking barrel and is fixedly connected with a shaft rod, the surface of the shaft rod is fixedly connected with a first driving gear and a second driving gear, the first driving gear and the breaking gear are meshed with each other, the second driving gear and the stirring gear are meshed with each other, the upper end of the partition is located inside the reaction barrel as a mixing box, the lower end of the partition is located inside the reaction barrel as a filter box, the filter assembly is located inside the filter box, the stirring assembly is located inside the mixing box, the lower end of the partition is fixedly connected with a connecting pipe, and the surface of the connecting pipe is provided with an electromagnetic valve.

[0008] Furthermore, as a preferred technical solution, the stirring assembly includes a stirring gear arranged at the lower end of the crushing barrel, the stirring gear and the lower end of the crushing barrel are rotatably connected to each other, the lower end of the stirring gear is fixedly connected to a stirring rod, the surrounding sides of the stirring rod are fixedly connected to stirring and mixing rods, and the stirring assembly is meshed with the driving assembly.

[0009] Further, as a preferred technical solution, the crushing barrel includes a bottom shell arranged at the upper end of the reaction barrel, the upper end of the bottom shell is fixedly connected to an observation shell, the upper end of the observation shell is fixedly connected to an upper cover, and the surface of the bottom shell is provided with filter holes.

[0010] Further, as an optimal technical solution, the filter assembly includes an inclined plate arranged inside the reaction barrel, the inner side of the inclined plate is fixedly connected to a filter arc plate, the outer side of the reaction barrel is fixedly connected to a discharge shell, the interior of the discharge shell is rotatably connected to a conveying auger, the conveying auger extends into the interior of the reaction barrel and is rotatably connected to the reaction barrel, the outer side of the reaction barrel is fixedly connected to a conveying motor, the output shaft of the conveying motor passes through the reaction barrel and is fixedly connected to the conveying auger, and the lower end of the discharge shell is fixedly connected to a discharge pipe.

[0011] Furthermore, as a preferred technical solution, a second feed pipe is fixedly connected to one side of the reaction barrel, the second feed pipe is communicated with the reaction barrel, and the other end of the second feed pipe is fixedly connected to a feed hopper.

[0012] Furthermore, as a preferred technical solution, the upper end of the base plate is fixedly connected to a shell, the interior of the shell is fixedly connected to an electric push rod, the other end of the electric push rod is fixedly connected to a universal wheel, and the universal wheel and the shell are slidably plugged into each other.

[0013] In summary, the utility model mainly has the following beneficial effects:

[0014] First, by setting the driving assembly and the crushing assembly, when in use, the driving assembly can be started to make the first driving gear drive the crushing gear to rotate, so that the crushing rod rotates under the rotation of the crushing gear and then drives the crushing piece to rotate, so that the intestinal mucosa can be crushed under the action of the crushing piece, and then the crushed intestinal mucosa will enter the interior of the reaction barrel under the action of the filter hole, and when the driving assembly is started, the second driving gear drives the stirring gear to rotate, so that the stirring rod rotates under the action of the stirring gear and drives the stirring and mixing rod to rotate, so that the intestinal mucosa and the reactant can be fully mixed under the action of the stirring and mixing rod, so as to increase the reaction effect of heparin sodium;

[0015] Secondly, by setting up the filtering component, the sodium heparin after the reaction is discharged into the interior of the filtering component through the connecting pipe, and then the conveying motor is turned on to rotate the conveying auger. The sodium heparin that enters the bottom of the reaction barrel will be filtered under the action of the filtering arc plate, and then the filtered impurities will enter the interior of the discharge shell under the action of the conveying auger and finally be discharged through the discharge pipe, thereby achieving the filtering effect. At the same time, it is also more convenient to clean the impurities, thereby increasing the practicability of the device, and at the same time, it is simple to use and has a good reaction effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 It is a structural schematic diagram of the utility model;

[0017] Figure 2It is a cross-sectional structural schematic diagram of the utility model;

[0018] Figure 3 It is a structural schematic diagram of the crushing assembly of the utility model;

[0019] Figure 4 The utility model Figure 1 Schematic diagram of the enlarged structure of part A.

[0020] Figure numerals: 1, bottom plate; 2, support rod; 3, reaction barrel; 4, crushing barrel; 41, bottom shell; 42, observation shell; 43, upper cover; 44, filter hole; 5, first feed inlet; 6, driving assembly; 61, driving motor; 62, shaft; 63, first driving gear; 64, second driving gear; 7, crushing assembly; 71, crushing gear; 72, crushing rod; 73, crushing piece; 8, stirring assembly; 81, stirring gear ; 82. Stirring rod; 83. Stirring and mixing rod; 9. Filter assembly; 91. Inclined plate; 92. Filter arc plate; 93. Conveying auger; 94. Discharge shell; 95. Discharge pipe; 96. Conveying motor; 10. Partition; 11. Mixing box; 12. Filter box; 13. Discharge pipe; 14. Second feed pipe; 15. Feed hopper; 16. Shell; 17. Electric push rod; 18. Universal wheel; 19. Connecting pipe; 20. Solenoid valve. DETAILED DESCRIPTION

[0021] Example

[0022] refer to Figures 1 to 4A heparin sodium preparation and salt hydrolysis reaction device of the present embodiment comprises a bottom plate 1, a support rod 2 is fixedly connected to the upper end of the bottom plate 1, a reaction barrel 3 is fixedly connected to the upper end of the support rod 2, a crushing barrel 4 is fixedly connected to the upper end of the reaction barrel 3, a driving component 6 is fixedly connected to the upper end of the crushing barrel 4, a first feed port 5 is fixedly connected to the upper end of the crushing barrel 4, a partition 10 is fixedly connected to the interior of the reaction barrel 3, a stirring component 8 is arranged at the lower end of the crushing barrel 4, a crushing component 7 is arranged inside the crushing barrel 4, a filtering component 9 is fixedly connected to the lower end of the reaction barrel 3, a discharge pipe 13 is fixedly connected to the lower end of the reaction barrel 3, and the crushing component 7 comprises a crushing gear 71 arranged at the upper end of the crushing barrel 4, the crushing gear 71 is rotatably connected to the upper end of the crushing barrel 4, and the lower end of the crushing gear 71 is fixedly connected to a crushing rod 72. The outer surfaces of the crushing rods 72 are fixedly connected with crushing pieces 73, the crushing assembly 7 is meshed with the driving assembly 6, the driving assembly 6 includes a driving motor 61 arranged at the upper end of the crushing barrel 4, the output shaft of the driving motor 61 passes through the crushing barrel 4 and is fixedly connected with the shaft rod 62, the surface of the shaft rod 62 is fixedly connected with the first driving gear 63 and the second driving gear 64, the first driving gear 63 and the crushing gear 71 are meshed with each other, the second driving gear 64 and the stirring gear 81 are meshed with each other, the upper end of the partition 10 is located inside the reaction barrel 3 as a mixing box 11, the lower end of the partition 10 is located inside the reaction barrel 3 as a filter box 12, the filter assembly 9 is located inside the filter box 12, the stirring assembly 8 is located inside the mixing box 11, the lower end of the partition 10 is fixedly connected with a connecting pipe 19, and the surface of the connecting pipe 19 is provided with an electromagnetic valve 20.

[0023] refer to Figure 2 and Figure 3 The stirring assembly 8 includes a stirring gear 81 arranged at the lower end of the crushing barrel 4, the stirring gear 81 is rotatably connected to the lower end of the crushing barrel 4, the lower end of the stirring gear 81 is fixedly connected to a stirring rod 82, and the surrounding sides of the stirring rod 82 are fixedly connected to stirring and mixing rods 83, and the stirring assembly 8 is meshed and connected with the driving assembly 6; the crushed intestinal mucosa will enter the interior of the reaction barrel 3 under the action of the filtering hole 44, and when the driving assembly 6 is started, the second driving gear 64 drives the stirring gear 81 to rotate, so that under the action of the stirring gear 81, the stirring rod 82 rotates and drives the stirring and mixing rod 83 to rotate, so that under the action of the stirring gear 81, the intestinal mucosa and the reactants can be fully mixed.

[0024] refer to Figure 1-Figure 3 The crushing barrel 4 includes a bottom shell 41 arranged at the upper end of the reaction barrel 3, an observation shell 42 is fixedly connected to the upper end of the bottom shell 41, an upper cover 43 is fixedly connected to the upper end of the observation shell 42, and filter holes 44 are opened on the surface of the bottom shell 41; the crushing effect of the crushing component 7 inside the crushing barrel 4 can be observed through the observation shell 42.

[0025] refer to Figure 1 and Figure 2 The filter assembly 9 includes an inclined plate 91 arranged inside the reaction barrel 3, a filter arc plate 92 is fixedly connected to the inner side of the inclined plate 91, a discharge shell 94 is fixedly connected to the outer side of the reaction barrel 3, a conveying auger 93 is rotatably connected to the interior of the discharge shell 94, the conveying auger 93 extends into the interior of the reaction barrel 3 and is rotatably connected to the reaction barrel 3, a conveying motor 96 is fixedly connected to the outer side of the reaction barrel 3, the output shaft of the conveying motor 96 penetrates the reaction barrel 3 and is fixedly connected to the conveying auger 93, and a discharge pipe 95 is fixedly connected to the lower end of the discharge shell 94; by turning on the conveying motor 96 to make the conveying auger 93 rotate, the heparin sodium entering the bottom of the reaction barrel 3 will be filtered under the action of the filter arc plate 92, and then the filtered impurities will enter the interior of the discharge shell 94 under the action of the conveying auger 93 and finally be discharged through the discharge pipe 95, thereby achieving a filtering effect.

[0026] refer to Figure 1 A second feed pipe 14 is fixedly connected to one side of the reaction barrel 3, and the second feed pipe 14 is connected to the reaction barrel 3. The other end of the second feed pipe 14 is fixedly connected to a feed hopper 15. The feed hopper 15 can be easily added to the reactants, making it more convenient to add materials.

[0027] refer to Figure 4 The upper end of the base plate 1 is fixedly connected to a shell 16, an electric push rod 17 is fixedly connected to the inside of the shell 16, and the other end of the electric push rod 17 is fixedly connected to a universal wheel 18, and the universal wheel 18 and the shell 16 are slidably plugged into each other; by controlling the electric push rod 17, the universal wheel 18 is extended out of the shell 16 under the action of the electric push rod 17, so that when the universal wheel 18 extends out of the shell 16, it can be moved by the universal wheel 18, and when fixing the device, the universal wheel 18 can be moved to the inside of the shell 16, so that the base plate 1 is in contact with the ground, so that when the base plate 1 is in contact with the ground, the contact area between the device and the ground can be increased, thereby achieving a further stabilizing effect.

[0028] Principle and advantages of use: firstly, by starting the driving assembly 6, the first driving gear 63 drives the crushing gear 71 to rotate, so that the crushing rod 72 rotates and then drives the crushing piece 73 to rotate under the rotation of the crushing gear 71, so that the intestinal mucosa can be crushed under the action of the crushing piece 73, and then the crushed intestinal mucosa will enter the interior of the reaction barrel 3 under the action of the filtering hole 44, and when the driving assembly 6 is started, the second driving gear 64 drives the stirring gear 81 to rotate, so that under the action of the stirring gear 81, the stirring rod 82 rotates and drives the stirring and mixing rod 83 to rotate, so that under the action of the stirring and mixing rod 83, the intestinal mucosa and the reactants can be fully mixed, so that the reaction effect of heparin sodium is increased, and the feeding hopper provided can facilitate the addition of reactants, making it more convenient to add materials, and then after the reaction is completed, the reacted heparin can be added. Sodium heparin is discharged into the interior of the filter assembly 9 through the connecting pipe 19, and then the conveying motor 96 is turned on to rotate the conveying auger 93. The sodium heparin entering the bottom of the reaction barrel 3 will be filtered under the action of the filter arc plate 92, and then the filtered impurities will enter the interior of the discharge shell 94 under the action of the conveying auger 93 and finally be discharged through the discharge pipe 95, thereby achieving the filtering effect and making it more convenient to clean the impurities. When the equipment needs to be moved, the electric push rod 17 is controlled, and the universal wheel 18 is extended out of the housing 16 under the action of the electric push rod 17, so that the universal wheel 18 can be moved when the universal wheel 18 extends out of the housing 16. When the device is fixed, the universal wheel 18 is moved to the interior of the housing 16 so that the bottom plate 1 is in contact with the ground, so that when the bottom plate 1 is in contact with the ground, the contact area between the device and the ground can be increased, thereby achieving a further stabilizing effect.

Claims

1. A heparin sodium preparation salt hydrolysis reaction device, characterized in that: The invention comprises a bottom plate (1), the upper end of the bottom plate (1) is fixedly connected to a support rod (2), the upper end of the support rod (2) is fixedly connected to a reaction barrel (3), the upper end of the reaction barrel (3) is fixedly connected to a crushing barrel (4), the upper end of the crushing barrel (4) is fixedly connected to a driving component (6), the upper end of the crushing barrel (4) is fixedly connected to a first feed port (5), the interior of the reaction barrel (3) is fixedly connected to a partition plate (10), the lower end of the crushing barrel (4) is located inside the reaction barrel (3) and is provided with a stirring component (8), and the interior of the crushing barrel (4) is provided with a crushing component (6). The filter assembly (9) is fixedly connected to the lower end of the reaction barrel (3), the discharge pipe (13) is fixedly connected to the lower end of the reaction barrel (3), the crushing assembly (7) comprises a crushing gear (71) arranged at the upper end of the crushing barrel (4), the crushing gear (71) and the upper end of the crushing barrel (4) are rotatably connected to each other, the lower end of the crushing gear (71) is fixedly connected to a crushing rod (72), the outer surface of the crushing rod (72) is fixedly connected to a crushing piece (73), and the crushing assembly (7) is meshedly connected to the driving assembly (6).

2. A heparin sodium preparation salt hydrolysis reaction device according to claim 1, characterized in that: The stirring assembly (8) comprises a stirring gear (81) arranged at the lower end of the crushing barrel (4); the stirring gear (81) and the lower end of the crushing barrel (4) are rotatably connected to each other; the lower end of the stirring gear (81) is fixedly connected to a stirring rod (82); the circumferential sides of the stirring rod (82) are fixedly connected to stirring and mixing rods (83); and the stirring assembly (8) and the driving assembly (6) are meshedly connected to each other.

3. A heparin sodium preparation salt hydrolysis reaction device according to claim 2, characterized in that: The driving assembly (6) comprises a driving motor (61) arranged at the upper end of the crushing barrel (4); the output shaft of the driving motor (61) passes through the crushing barrel (4) and is fixedly connected to a shaft rod (62); the surface of the shaft rod (62) is fixedly connected to a first driving gear (63) and a second driving gear (64); the first driving gear (63) is meshedly connected to the crushing gear (71); and the second driving gear (64) is meshedly connected to the stirring gear (81).

4. A heparin sodium preparation salt hydrolysis reaction device according to claim 1, characterized in that: The upper end of the partition (10) is located inside the reaction barrel (3) as a mixing box (11), the lower end of the partition (10) is located inside the reaction barrel (3) as a filtering box (12), the filtering component (9) is located inside the filtering box (12), and the stirring component (8) is located inside the mixing box (11).

5. A heparin sodium preparation salt hydrolysis reaction device according to claim 1, characterized in that: The lower end of the partition (10) is fixedly connected to a connecting pipe (19), and a solenoid valve (20) is provided on the surface of the connecting pipe (19).

6. A heparin sodium preparation salt hydrolysis reaction device according to claim 1, characterized in that: The crushing barrel (4) comprises a bottom shell (41) arranged at the upper end of the reaction barrel (3); the upper end of the bottom shell (41) is fixedly connected to an observation shell (42); the upper end of the observation shell (42) is fixedly connected to an upper cover (43); and the surface of the bottom shell (41) is provided with filter holes (44).

7. A heparin sodium preparation salt hydrolysis reaction device according to claim 1, characterized in that: The filter assembly (9) comprises an inclined plate (91) arranged inside the reaction barrel (3), the inner side of the inclined plate (91) is fixedly connected to a filter arc plate (92), the outer side of the reaction barrel (3) is fixedly connected to a discharge shell (94), the interior of the discharge shell (94) is rotatably connected to a conveying auger (93), the conveying auger (93) extends into the interior of the reaction barrel (3) and is rotatably connected to the reaction barrel (3), the outer side of the reaction barrel (3) is fixedly connected to a conveying motor (96), the output shaft of the conveying motor (96) passes through the reaction barrel (3) and is fixedly connected to the conveying auger (93), and the lower end of the discharge shell (94) is fixedly connected to a discharge pipe (95).

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