Efficient chemiluminescence immunoassay analyzer

Abstract

The utility model belongs to the technical field of medical instruments, and particularly relates to an efficient chemiluminescence immunity analyzer. The high-efficiency chemiluminescence immunoassay analyzer comprises: a frame body; the batten feeding system is arranged on the frame body, the batten feeding system comprises a first buffer area and a third buffer area which are sequentially arranged from left to right, and battens move along the first buffer area and the third buffer area; the sample arm is movably arranged on the frame body in the left-right direction, and the sample arm can move to the position above the first buffer area for sample adding; the reagent arm is movably arranged on the frame body in the left-right direction, and the reagent arm can move to the position above the third buffer area to add a reagent. According to the chemiluminescence immunoassay analyzer, the working efficiency of the chemiluminescence immunoassay analyzer can be improved.

Description

Technical Field

[0001] The utility model belongs to the technical field of medical devices, and specifically relates to a high-efficiency chemiluminescence immunoassay analyzer. Background Art

[0002] Chemiluminescent labeling immunoassay, also known as chemiluminescent immunoassay (CLIA), is an immunoassay method that directly labels antigens or antibodies with chemiluminescent agents. The chemiluminescent immunoassay instrument consists of two parts, namely the immunoreaction system and the chemiluminescent analysis system. The chemiluminescent analysis system uses the catalysis of the chemiluminescent substance and the oxidation of the oxidant to form an excited intermediate. When this excited intermediate returns to a stable ground state, it simultaneously emits a photon (hM), and the light quantum yield is measured using a luminescent signal measuring instrument. The immunoreaction system is to directly label the luminescent substance (an excited intermediate generated under the excitation of the reactant) on the antigen (chemiluminescent immunoassay) or antibody (immunochemiluminescent assay), or an enzyme acts on a luminescent substrate.

[0003] Chinese patent document CN103267867B discloses a fully automatic chemiluminescent immunoassay analyzer, which includes a frame and a control system, wherein the frame is provided with a sample area, a slat feeding system, an incubation area and a slat detection system from left to right, a liquid circuit system is provided below or on the right side of the incubation area, a reagent area is provided below the incubation area, below the slat detection system or on the right side, a sample arm is provided on the left side of the frame, and a reagent arm is provided on the right side, a first push rod arm is provided above the slat feeding system on the frame, and a second push rod arm is provided inside the incubation area, and the slat feeding system, incubation area, slat detection system, liquid circuit system, sample arm, reagent arm, first push rod arm and second push rod arm are electrically connected to the control system respectively. The utility model provides an efficient chemiluminescent immunoassay analyzer with simple structure, convenient operation, high degree of automation and support for non-stop loading.

[0004] However, during the operation, the sample arm and reagent arm of the fully automatic chemiluminescence immunoassay analyzer need to be moved alternately to the top of the slat feeding system to add samples or reagents to the slats transported by the slat feeding system, which results in low working efficiency. Utility Model Content

[0005] In view of the technical problems mentioned above, the utility model aims to provide a high-efficiency chemiluminescence immunoassay analyzer, which can improve the working efficiency of the chemiluminescence immunoassay analyzer.

[0006] According to the utility model, a high-efficiency chemiluminescence immunoassay analyzer is provided, comprising:

[0007] Frame;

[0008] A slat feeding system, wherein the slat feeding system is arranged on the frame, wherein the slat feeding system comprises a slat upper frame area, a first buffer area, a second buffer area and a third buffer area which are arranged in sequence from left to right;

[0009] A sample arm, the sample arm is movably arranged on the frame along the left and right directions, and the sample arm can be moved to the top of the first buffer zone to add samples;

[0010] A reagent arm is movably arranged on the frame along the left-right direction, and the reagent arm can move to the top of the third buffer zone to add reagent.

[0011] In a specific embodiment, the slat feeding system includes a third motor and a third sliding mechanism, and the third motor drives the third sliding mechanism to make the slat move back and forth in the first buffer zone.

[0012] In a specific embodiment, the slat feeding system includes a first push rod arm, which is fixedly connected to the third sliding mechanism, and a mounting plate is fixedly provided on the first push rod arm. The mounting plate covers the slat upper shelf area, the first buffer zone, the second buffer zone and the third buffer zone in the left and right directions, and a motor synchronous belt is provided on the mounting plate.

[0013] In a specific embodiment, the slat feeding system includes a plurality of first push rod arms, and the mounting plates on each of the first push rod arms respectively cover different areas in the slat upper shelf area, the first buffer zone, the second buffer zone and the third buffer zone in the left and right directions.

[0014] The first buffer and the third buffer are of the same size.

[0015] In a specific embodiment, a dilution oscillation zone is further provided on the frame, and the dilution oscillation zone is located between the sample zone and the slat feeding system.

[0016] In a specific embodiment, an incubation zone is further provided on the frame, and the incubation zone is located on the right side of the slat feeding system. A slat detection system is also provided on the frame, and the slat detection system is located on the right side of the incubation zone.

[0017] In a specific embodiment, a reagent area is also provided on the frame, and the reagent area is located on the right side of the slat feeding system.

[0018] In a specific embodiment, a photosensitive liquid is also arranged on the frame, and the photosensitive liquid is located between the reagent area and the slat feeding system.

[0019] In a specific embodiment, a cleaning liquid is also provided on the frame, and the cleaning liquid is located between the reagent area and the slat feeding system.

[0020] In a specific embodiment, the cleaning liquid is located in front of the photosensitive liquid.

[0021] Compared with the prior art, the advantages of this application are:

[0022] The utility model sets a first buffer zone, a second buffer zone and a third buffer zone so that the strips can be located in the above three areas respectively. The sample arm and the reagent arm respectively select two of the above buffer zones, add samples and reagents to the strips in the buffer zones, thereby performing operations on more strips in the same time, saving working time and improving work efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] The utility model will be described below with reference to the accompanying drawings.

[0024] Figure 1 A schematic diagram showing an embodiment of a high-efficiency chemiluminescent immunoassay analyzer according to the utility model is shown;

[0025] Figure 2 A schematic diagram showing an embodiment of a slat feeding system of a high-efficiency chemiluminescent immunoassay analyzer according to the present invention;

[0026] Figure 3 The schematic diagram of the top view of the high-efficiency chemiluminescent immunoassay analyzer according to the utility model is shown;

[0027] Figure 4 It is a structural schematic diagram of the incubation zone of the utility model;

[0028] Figure 5 It is a structural schematic diagram of the lath detection system of the utility model;

[0029] Figure 6 This is a structural schematic diagram of the slat movable module of the utility model;

[0030] Figure 7 This is a structural schematic diagram of the sliding module of the utility model;

[0031] Figure 8 It is a structural schematic diagram of the slat fixing fork of the utility model;

[0032] Fig. 9 It is a structural schematic diagram of the slat frame described in the utility model.

[0033] In the figure:

[0034] 1. Frame; 2. Control system; 3. Sample area; 4. Slat feeding system; 5. Incubation area; 6. Slat detection system; 7. Reagent area; 8. Sample arm; 9. Reagent arm; 10. First push rod arm; 11. Second push rod arm; 12. Slat rack; 13. Housing; 14. Stack door; 15. First motor; 16. First sliding mechanism; 17. Slat; 18. Grip; 19. Second motor; 20. Second sliding mechanism; 21. Sample buffer base; 22. Third motor; 23. Third sliding mechanism; 210. Slat rack area; 211. First buffer; 212. Second buffer; 213. Third buffer; 24. Incubation area base; 25. Fourth motor; 26. Fourth Sliding mechanism; 27, photosensitive liquid sample injection needle; 28, photosensitive liquid; 29, cleaning liquid; 30, plunger pump; 31, detection module; 32, sliding module; 33, slat driving module; 34, slat movable module; 35, slat slide groove; 36, front door; 37, rear door; 38, front door reset mechanism; 39, slot; 40, rear door reset mechanism; 41, jack; 42, slot; 43, fixing plate; 44, slat fixing fork; 45, DC motor; 46, lead screw; 47, slide rail; 48, driving gear; 49, driven gear; 50, front door plug rod; 51, rear door plug rod; 52, insert; 53, through groove; 54, dilution oscillation zone; 55, block; 56, clamping plate; 57, screw.

[0035] In the present application, all drawings are schematic drawings, which are only used to illustrate the principles of the present utility model and are not drawn according to the actual scale. DETAILED DESCRIPTION

[0036] The utility model is introduced below by means of the accompanying drawings.

[0037] As an embodiment of the high-efficiency chemiluminescent immunoassay analyzer of the utility model, Figure 1 As shown, it includes a frame 1 and a control system 2, wherein the frame 1 is provided with a sample area 3, a slat feeding system 4, an incubation area 5 and a slat detection system 6 from left to right, a liquid path system is provided below the incubation area 5, a reagent area 7 is provided below the incubation area 5, a sample arm 8 is provided on the left side of the frame 1, and a reagent arm 9 is provided on the right side, a second pusher arm 11 is provided above the slat feeding system 4 on the frame 1 and inside the incubation area 5, and the slat feeding system 4, incubation area 5, slat detection system 6, liquid path system, sample arm 8, reagent arm 9, first pusher arm 10 and second pusher arm 11 are electrically connected to the control system 2 respectively.

[0038] In this embodiment, Figure 2As shown, the slat feeding system 4 includes a slat frame 12, a plate feeding device, a plate taking device and a sample loading buffer device, the plate feeding device, the plate taking device and the sample loading buffer device are all fixed on the frame 1, the plate taking device is arranged behind the plate feeding device, the sample loading buffer device is arranged between the plate taking device and the incubation area 5, the plate feeding device, the plate taking device and the sample loading buffer device are respectively electrically connected to the control system 2; the plate feeding device includes a shell 13, a stack door 14, a first motor 15 and a first sliding mechanism 16, after the user places the slat 17 on the slat frame 12, it is placed into the lower part of the shell 13 from the stack door 14, and driven by the first motor 15 through the first sliding mechanism 16 The slat frame 12 is lifted to the upper part of the shell 13 in the vertical direction; the plate taking device includes a gripper 18, a second motor 19 and a second sliding mechanism 20, and the gripper 18 takes the slat frame 12 out of the shell 13 in the horizontal longitudinal direction under the drive of the second motor 19 and the second sliding mechanism 20; the sample loading buffer device includes a sample loading buffer base 21, a third motor 22 and a third sliding mechanism 23, and the slats 17 on the slat frame 12 are horizontally moved to the sample loading buffer base 21 through the mounting plate on the first push rod arm 10, and then the slat frame 12 is driven by the third motor 22 and the third sliding mechanism 23 to make a horizontal and horizontal linear motion on the sample loading buffer base 21 and move to the incubation area 5.

[0039] According to the present invention, the sample buffer base 21 can place at least two groups of slats 17 along the direction from the slat feeding system 4 to the incubation zone 5. Figure 3 Under this setting, after the first group of slats 17 are moved from the slat feeding system 4 to the leftmost side of the sample loading buffer base 21, the sample arm 8 can stay above the leftmost side of the sample loading buffer base 21 to load samples on the first group of slats 17; then, the second group of slats 17 are moved from the slat feeding system 4 to the leftmost side of the sample loading buffer base 21, and at the same time, the first group of slats 17 move to the right, that is, the second group of slats 17 move to the original position of the first group of slats 17, the sample arm 8 loads samples on the second group of slats 17, and the first group of slats 17 move to the right side of the second group of slats 17. At this time, the reagent arm 9 can stay above the first group of slats 17 to add reagents to the first group of slats 17.

[0040] In a specific embodiment, the sample loading buffer base 21 includes a slat rack area 210, a first buffer area 211, a second buffer area 212 and a third buffer area 213. The first buffer area 211, the second buffer area 212 and the third buffer area 213 are located on the same horizontal plane and are arranged from left to right between the slat feeding system 4 and the incubation area 5. Figure 3 shown.

[0041] Further, in this embodiment, the sample arm 8 is located above the first buffer zone 211, and is moved to the strip 17 of the first buffer zone 211 for sample addition. The reagent arm 9 is located above the third buffer zone 213, and is moved to the strip 17 of the third buffer zone 213 for reagent addition.

[0042] The second buffer area 212 can ensure a certain distance between the first buffer area 211 and the third buffer area 213 , thereby preventing the sample arm 8 and the reagent arm 9 from interfering with each other when they move above the first buffer area 211 and the third buffer area 213 .

[0043] In a specific embodiment, the strip 17 is set to an 8*8 specification (i.e., the strip 17 includes 8*8 reaction cups), and the samples and reagents are aspirated and divided into eight portions (i.e., 8 samples or reagents are aspirated at one time, and then each sample or reagent is distributed into the corresponding reaction cup).

[0044] The time for one sample to suck eight minutes is 23 seconds, and the time for one reagent to suck eight minutes is 23 seconds. The specifications of the slats 17 of this embodiment have 8 sample distributions and 16 reagent distributions. In the prior art, after the slats 17 are moved to the sample buffer base 21, it is necessary to make the sample arm 8 and the reagent arm 9 move alternately to the top of the sample buffer base 21 for operation, and each of the push slats 17 is calculated by 3 seconds, and the number of batches (the number of groups of slats 17) is n (n≥1), then the overall time of the prior art solution is (23*8+23*16+3*8*2)*n, that is, the corresponding flux is 8*8*3600 / (23*8+23*16+3*8*2)=384 tests / h. The overall time of the solution of this embodiment is 23*8+(23*16+3*8*3)*n. When n tends to infinity, the limiting flux is 8*8*3600 / (23*16+3*8*3)=523 tests / h.

[0045] The advantages of this embodiment over the prior art are described below through a table.

[0046]

[0047] In a specific embodiment, the first buffer zone 211, the second buffer zone 212 and the third buffer zone 213 can share a set of third motor 22 and third sliding mechanism 23 to move the slat 17. In another embodiment, the first buffer zone 211, the second buffer zone 212 and the third buffer zone 213 can be respectively provided with a third motor 22 and a third sliding mechanism 23 to move the slat 17.

[0048] The remaining structures of the present invention can refer to the contents disclosed in Chinese patent document CN103267867B, which are as follows.

[0049] In this embodiment, Figure 4 As shown, the incubation zone 5 includes a light-proof shell (not shown in the figure), an incubation zone base 24, a fourth motor 25, a fourth sliding mechanism 26 and a second push rod arm 11. The incubation zone base 24, the fourth sliding mechanism 26 and the second push rod arm 11 are all arranged inside the light-proof shell. The sample-loaded slat 17 is moved from the sample loading buffer base 21 to the incubation zone base 24, and oscillates under the drive of the fourth motor 25 and the fourth sliding mechanism 26. A photosensitive liquid loading needle 27 is provided on the second push rod arm 11. The liquid path system includes a photosensitive liquid 28 and a cleaning liquid 29, which are connected to the photosensitive liquid 28 through a plunger pump 30.

[0050] In this embodiment, Figure 5 As shown, the slat detection system 6 includes a detection module 31, a sliding module 32, a slat driving module 33 and a slat movable module 34, the detection module 31 is located above the slat movable module 34, and the sliding module 32 is slidably arranged above the slat driving module 33.

[0051] In this embodiment, Figure 6 As shown, the slat movable module 34 includes a slat slide groove 35, a front door 36 and a rear door 37, the slat 17 is arranged in the slat slide groove 35, the front door 36 is arranged at one end of the slat slide groove 35 through a front door reset mechanism 38, a slot 39 is provided at the lower part of the other end of the slat slide groove 35, the rear door 37 is arranged above the slot 39 through a rear door reset mechanism 40, a socket 41 is provided on the front door 36, and a slot 42 is provided on the rear door 37.

[0052] In this embodiment, Figure 7 and Figure 8 As shown, the sliding module 32 includes a fixed plate 43, a slat fixing fork 44, a DC motor 45 and a lead screw 46. The slat fixing fork 44 is slidably connected to the fixed plate 43 through a slide rail 47. The DC motor 45 is fixed to the fixed plate 43 and is provided with a driving gear 48 at the output end. One end of the lead screw 46 is connected to the slat fixing fork 44 and the other end is provided with a driven gear 49. The driving gear 48 and the driven gear 49 are engaged with each other. One side of the slat fixing fork 44 A front door plug rod 50 is provided, and the front door plug rod 50 is inserted into the insertion hole 41 of the front door 36 when it is necessary to drive the front door 36. A rear door plug rod 51 is provided on the lower surface of the slat fixing fork 44, and the rear door plug rod 51 is inserted into the slot 42 of the rear door 37 when it is necessary to drive the rear door 37. Seven insert pieces 52 are provided on the slat fixing fork 44, and a through groove 53 is provided on the side wall of the slat slide groove 35. The insert piece 52 passes through the through groove 53 and is inserted into the gap between the slats 17.

[0053] In this embodiment, the high-efficiency chemiluminescence immunoassay analyzer further includes a dilution oscillation zone 54 , which is fixed to the frame 1 and located between the sample zone 3 and the slat feeding system 4 .

[0054] like Fig. 9 As shown, in this embodiment, two stoppers 55 are provided on the lower surface of the slat frame 12, and both ends of the stoppers 55 are rounded.

[0055] In this embodiment, the sample buffer area base 21 and the incubation area base 24 are both provided with clamping pieces 56 , and the slat slide groove 35 is provided with clamping pieces 56 , and both are fixed by screws 57 .

[0056] In this embodiment, a shell (not shown in the figure) is disposed outside the frame 1.

[0057] It should be noted that the directional terms or qualifiers "upper", "lower", "front", "rear", "left", "right", etc. used in this application are all with reference to the drawings to which they are referred. They are not used to limit the absolute positions of the components involved, but can be changed according to specific circumstances.

[0058] In the description of the present utility model, it should be understood that the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Therefore, a feature defined as "first" or "second" may explicitly or implicitly include one or more of the features. In the description of the present utility model, the meaning of "plurality" is two or more, unless otherwise clearly and specifically defined.

[0059] In the present invention, unless otherwise clearly specified and limited, the terms "install", "connect", "connect", "fix" and the like should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be an indirect connection through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0060] In the description of this specification, the description with reference to the terms "one embodiment", "some embodiments", "example", "specific example", or "some examples" means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the utility model. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

[0061] Finally, it should be noted that the above is only a preferred embodiment of the utility model and does not constitute any limitation to the utility model. Although the utility model is described in detail with reference to the aforementioned embodiments, it is still possible for a person skilled in the art to modify the technical solutions described in the aforementioned embodiments or to replace some of the technical features therein by equivalents. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the utility model shall be included in the protection scope of the utility model.

Claims

1. A high-efficiency chemiluminescent immunoassay analyzer, characterized in that: include: Frame (1); A slat feeding system (4), the slat feeding system (4) being arranged on the frame (1), wherein the slat feeding system (4) comprises a slat upper frame area (210), a first buffer area (211), a second buffer area (212) and a third buffer area (213) arranged in sequence from left to right; A sample arm (8), the sample arm (8) being movably arranged on the frame (1) in the left-right direction, and the sample arm (8) being capable of moving to the top of the first buffer zone (211) to add a sample; A reagent arm (9), wherein the reagent arm (9) is movably arranged on the frame (1) in the left-right direction, and the reagent arm (9) can be moved to the top of the third buffer zone (213) to add reagent.

2. The high-efficiency chemiluminescent immunoassay analyzer according to claim 1, characterized in that: The slat feeding system (4) comprises a third motor (22) and a third sliding mechanism (23), and the third motor (22) drives the third sliding mechanism (23) to make the slat (17) move back and forth in the first buffer zone (211).

3. The high-efficiency chemiluminescent immunoassay analyzer according to claim 2, characterized in that: The slat feeding system (4) comprises a first push rod arm (10), the first push rod arm (10) is fixedly connected to the third sliding mechanism (23), a mounting plate is fixedly arranged on the first push rod arm (10), the mounting plate covers the slat upper rack area, the first buffer zone, the second buffer zone and the third buffer zone in the left-right direction, and a motor synchronous belt is arranged on the mounting plate.

4. The high-efficiency chemiluminescent immunoassay analyzer according to claim 1, characterized in that: The slat feeding system (4) comprises a plurality of first push rod arms (10), and the mounting plates on each of the first push rod arms (10) respectively cover different areas in the slat upper rack area, the first buffer area, the second buffer area and the third buffer area in the left and right directions.

5. The high-efficiency chemiluminescent immunoassay analyzer according to claim 1, characterized in that: The first buffer (211) and the third buffer (213) have the same size.

6. The high-efficiency chemiluminescent immunoassay analyzer according to any one of claims 1 to 5, characterized in that: The frame (1) is also provided with an incubation zone (5), and the incubation zone (5) is located on the right side of the slat feeding system (4). The frame (1) is also provided with a slat detection system (6), and the slat detection system (6) is located on the right side of the incubation zone (5).

7. The high-efficiency chemiluminescent immunoassay analyzer according to any one of claims 1 to 4, characterized in that: A reagent area (7) is also provided on the frame (1), and the reagent area (7) is located on the right side of the slat feeding system (4).

8. The high-efficiency chemiluminescent immunoassay analyzer according to claim 7, characterized in that: A photosensitive liquid (28) is also arranged on the frame (1), and the photosensitive liquid (28) is located between the reagent area (7) and the slat feeding system (4).

9. The high-efficiency chemiluminescent immunoassay analyzer according to claim 8, characterized in that: A cleaning liquid (29) is also provided on the frame (1), and the cleaning liquid (29) is located between the reagent area (7) and the slat feeding system (4).

10. The high-efficiency chemiluminescent immunoassay analyzer according to claim 9, characterized in that: The cleaning liquid (29) is located in front of the photosensitive liquid (28).

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