Preparation method of super-molecular nano fiber for magnetic resonance imaging radiography

A magnetic resonance imaging and nanofiber technology, which is applied in the field of supramolecular nanofiber preparation, can solve the problems of long detection time, high detection cost, low sensitivity, etc., and achieves the advantages of simple preparation method, strong bonding ability and broad application prospects. Effect

CN102961765AInactive Publication Date: 2013-03-13NANKAI UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Publication Date
2013-03-13
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a preparation method of a super-molecular nano fiber for magnetic resonance imaging radiography. A construction unit takes diPMCD as a main body; manganese porphyrin is taken as a secondary body; and a super-molecular assembly body is constructed by mutual inclusion and complexation effects of the main body and the secondary body. The preparation method comprises the following steps of: dissolving 6-isothiocyano-6-deoxy-fully methylated beta-cyclodextrin and ethanediamine into acetonitrile under the protection of argon; agitating at a room temperature for one night; carrying out spinning evaporation to remove a solvent; purifying a residual solid by using column chromatography to obtain a white diPMCD solid; dissolving the diPMCD and the manganese porphyrin into water and mixing uniformly; and adding sodium ascorbate to obtain a target object. The preparation method has the advantage of being is simple and the components have relatively strong bonding capability; the super-molecular nano fiber can be effectively imaged in a body of a mouse and has a wide application prospect in the field of a magnetic resonance imaging contrast agent; and the invention provides a novel method for preparing the contrast agent.
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Description

Technical field

[0001] The invention belongs to nano supramolecular materials, in particular to a preparation method of supramolecular nanofibers used for magnetic resonance imaging contrast.

Background technique

[0002] Magnetic Resonance Imaging (Magnetic Resonance Imaging) is a new type of high-tech imaging examination method in recent years, which uses non-invasive radiation to obtain spatially and temporally resolved three-dimensional (3D) images of the entire living body. Although this new diagnostic technique was only used in clinical medicine in the early 1980s, it has no ionizing radiation (radiation) damage, no bony artifacts, and can be multi-directional (transverse, coronal, sagittal, etc.) And the unique advantages of multi-parameter imaging, high soft tissue resolution, and the ability to display vascular structures without the use of contrast agents have become the main means of diagnosis and monitoring of some diseases, see: 1) C.H.Polman, S.C.Reingold, ...

Examples

Embodiment

[0024] A method for preparing supramolecular nanofibers for magnetic resonance imaging contrast, comprising the steps of:

[0025] 1) Dissolve 630mg of 6-isothiocyanato-6-deoxy-permethylated β-cyclodextrin and 13mg of ethylenediamine in 10mL of acetonitrile solvent under the protection of argon, and stir at 22°C for 10 hours, The solvent was removed by rotary evaporation, and the remaining solid was purified by column chromatography to obtain 300 mg of white diPMCD solid with a yield of 51%.

[0026]1H NMR (400MHz, CDCl3) δ7.54(s,2H),6.28(s,2H),5.13(d,J=10.4Hz,10H),5.01(s,2H),4.94(s,2H),4.20 –3.04(m,208H).13C NMR(100MHz,CDCl3)δ182.63,99.88,99.08,98.98,98.82,82.29,82.10,81.92,81.76,81.63,81.10,80.41,80.24,80.13,77.26,71.40, ,71.07,71.00,70.90,70.83,70.01,61.64,61.54,61.41,61.36,61.32,59.41,59.24,59.11,59.04,58.86,58.71,58.65,58.53,58.39,43.95,42.97 z:[M+Na]+calcd for C 128 h 226 N 4 o 68 S 2 Na + 2994.3638;found: 2994.3680.

[0027] 2) Dissolve 15mg diPMCD and 12.5mg m...