Multi-organ preservation device

Abstract

This invention discloses a multi-organ preservation device. The liver is stored in a water bath, while other organs are preserved within a separate multi-organ container. Blood, propelled by a peristaltic pump, enters an oxygenation device, where oxygen from an oxygen cylinder mixes with the blood. After sufficient oxygenation, a drug delivery system pushes medication or nutrients from the liver into the bloodstream, where it mixes with the blood and then flows through the arteries of each organ to the respective organs. After passing through each organ, the blood returns to a filter, where bubbles and impurities are filtered before flowing back to the peristaltic pump. The flow rate and velocity of the inlet tube are controlled by a flow control valve. This device is simple in structure, easy to operate, and capable of preserving ex vivo organs for extended periods.

Description

Technical Field

[0001] This invention relates to a novel organ preservation system, and more particularly to a multi-organ preservation device. Background Technology

[0002] The purpose of organ transplantation is to replace organs that have lost function due to fatal diseases, enabling the recipient to regain the corresponding organ and perform normal functions. Commonly used transplant organs include kidneys, hearts, livers, pancreas and islets of Langerhans, parathyroid glands, heart and lungs, bone marrow, and corneas. The living donor organs required for transplantation generally come from another person. The organ needs to be removed from the donor body. The removed, ischemic organ dies within a short period (from a few minutes to no more than an hour) and cannot be used for transplantation. Completing the transplant surgery within such a short time is impossible. Therefore, it is essential to maintain the organ's viability to ensure its survival from the time it leaves the donor body until the transplant surgery.

[0003] Currently, the most common method is cryopreservation. The cryopreservation method reduces the energy consumption of organs by lowering the temperature, thereby extending the preservation time. However, low temperature can only slow down the rate of cell death, not prevent it. At the same time, low temperature may also cause damage to tissue cells.

[0004] Patent 201410384703.9 discloses a low-temperature or sub-normal-temperature kidney preservation device, indicating an initial consideration of organ preservation at sub-normal temperatures to improve the quality of kidney preservation. Patent 201410016261.2 discloses a device and method for preserving ex vivo organs, which provides continuous nutrients and oxygen to the ex vivo organs through mechanical perfusion and membrane oxygenation. Patent 201510085562.5 discloses a safety-enhanced low-temperature mechanical perfusion preservation device for organs, which preserves organs at low temperatures and simultaneously achieves different perfusion modes through various pump control signals. Patent 201310723787.X discloses a transplant organ protection bag; this device has a simple structure, but it can only preserve organs at low temperatures and cannot provide oxygen or circulating blood. The above patents only address the preservation of one type of organ and cannot preserve multiple organs simultaneously.

[0005] By perfusing blood with oxygen and nutrients, a healthy human tissue can be simulated, which can not only preserve human organs for a long time, but also has a repairing effect on organs such as the liver. Summary of the Invention

[0006] The purpose of this invention is to overcome the shortcomings of existing technologies and provide a multi-organ preservation device with a simple structure and good operability.

[0007] To achieve the above objectives, the technical solution adopted by the present invention is as follows:

[0008] A multi-organ preservation device includes a trolley on which a multi-organ preservation apparatus is mounted, the multi-organ preservation apparatus comprising:

[0009] A water bath contains a multi-organ container. The multi-organ container has at least four compartments, each for holding a different organ. The bottoms of all the compartments are interconnected by pipes. Each compartment has an outlet at its bottom. A container cover is placed over the multi-organ container. The container cover is sealed to the multi-organ container by two symmetrically arranged container cover buckles on its front and back sides. An antibacterial cover is placed over the container cover and is tightly fastened to the multi-organ container cover by antibacterial cover buckles. A temperature sensor is installed in the water bath.

[0010] An oxygenation device is provided, wherein the inlet of the oxygenation device is connected to the outlet of a peristaltic pump via a pipe, the outlet of an oxygen cylinder is connected to the inlet of the oxygenation device via an oxygen pipe, the outlet of the oxygenation device is connected to a main delivery pipe, the outlets of multiple drug delivery devices are respectively connected to the main delivery pipe via drug delivery pipes, the outlet of the main delivery pipe is divided into multiple branches, each branch is equipped with an inlet flow control valve, the outlet end of each branch passes through a water bath and a multi-organ container and is connected to the tissues, organs, arteries and blood vessels in each tank of the multi-organ container, the tank outlet is connected to an outlet pipe, the outlet pipe passes through the water bath and the multi-organ container and is connected to an outlet main pipe that is sequentially connected to an outlet flow control valve, a filter and a peristaltic pump outlet, the filtrate outlet of the filter is lower than the liquid level in the multi-organ container.

[0011] At least three graduated organ secretion containers are used to collect organ secretions. Each organ container is connected to the corresponding organ secretion pipe in each compartment of the multi-organ container through a secretion outlet pipe passing through the water bath.

[0012] A touch screen is connected to a controller. The touch screen outputs control signals to the controller and reads and displays the signals output by the controller. The controller is connected to a peristaltic pump, an inlet flow control valve, an outlet flow control valve, and a temperature sensor. The controller reads the signal from the temperature sensor and outputs a temperature control signal to the water bath to heat the water in the water bath. The controller reads the signals from the inlet flow control valve and the outlet flow control valve, and then outputs a rotation control signal to the peristaltic pump.

[0013] Compared with the prior art, the multi-organ preservation device provided by the present invention has the following beneficial effects:

[0014] 1. The multi-organ preservation device of the present invention has a simple structure, is easy to operate, and can preserve organs outside the body for a long time, and can even repair organs.

[0015] 2. The multi-organ preservation device of the present invention can simultaneously preserve and repair organs such as liver, kidney, and pancreas, and can preserve up to four organs at the same time, thereby maximizing organ utilization.

[0016] 3. The multi-organ preservation device of the present invention controls the peristaltic pump to supply blood flow and the flow control valve to regulate flow and pressure, which can ensure a suitable blood flow supply during operation and increase the liver preservation time and repair quality through the supply of oxygen, drugs or nutrients.

[0017] 4. The multi-organ preservation device of the present invention can intelligently control the temperature of the water bath through a controller, which can ensure that the liver is preserved and repaired at the required temperature, and prevent liver damage caused by abnormal temperature conditions to the greatest extent.

[0018] 5. The multi-organ preservation device of the present invention is in the form of a trolley, which is convenient for doctors or related staff to move, flexible when retrieving organs, and can also be used as a training system for live experiments. Attached Figure Description

[0019] Figure 1 This is a schematic diagram illustrating the principle of the multi-organ preservation device of the present invention;

[0020] Figure 2 This is a schematic diagram of the structure of the multi-organ preservation device with a forward-looking angle according to the present invention;

[0021] Figure 3 This is a schematic diagram of the structure of the multi-organ preservation device with a rear-view angle according to the present invention. Detailed Implementation

[0022] The present invention will now be described in detail with reference to specific embodiments and accompanying drawings.

[0023] The multi-organ preservation device of the present invention, as shown in the attached figures, includes a trolley that can be pushed by staff during the entire process of organ collection and transportation, as well as for demonstrations, simple surgeries, and experiments. A multi-organ preservation device is mounted on the trolley, which includes:

[0024] A water bath 300, which can be a commercially available product or a customized product, is provided, with its size determined according to actual needs. A multi-organ container 108 is placed inside the water bath 300. The multi-organ container 108 has at least four compartments, each for holding a different organ. The bottoms of all the compartments are interconnected by pipes, and each compartment has an outlet at its bottom. A container cover 109 covers the multi-organ container 108, and the container cover 109 is sealed to the multi-organ container 108 on both the front and back sides by two symmetrically arranged container cover buckles 113, ensuring that the organs do not fall out of the multi-organ container cover 109 during transportation. An antibacterial cover 111 covers the outside of the container cover 109, and the antibacterial cover 111 is tightly fastened to the multi-organ container cover 108 by antibacterial cover buckles 112, preventing bacteria from entering the multi-organ container 108. A temperature sensor is installed inside the water bath 300.

[0025] An oxygenation device 103 is provided, with its inlet connected to the outlet of a peristaltic pump 116 via a pipe. An oxygen cylinder 102 has its outlet connected to the inlet of the oxygenation device 103 via an oxygen pipe. The outlet of the oxygenation device 116 is connected to a main delivery pipe. Multiple drug delivery devices 101 have their outlets connected to the main delivery pipe via drug delivery pipes. The main delivery pipe has multiple branches at its outlet, each branch equipped with an inlet flow control valve 107-1. The outlet of each branch passes through a water bath 300 and a multi-organ container 108, connecting to the tissues, organs, arteries, and blood vessels in each compartment of the multi-organ container 108. The compartment outlet is connected to an outlet pipe, which passes through the water bath 300 and the multi-organ container 108 and connects to an outlet main pipe sequentially connected to an outlet flow control valve 107-2, a filter 120, and the outlet of the peristaltic pump 116. The filter 120 should be installed slightly low to ensure that the filter filtrate outlet is below the liquid level in the multi-organ container 108. The inlet flow control valve can be adjusted manually or electrically to control the blood flow rate.

[0026] At least three graduated organ secretion containers 115 are used to collect organ secretions such as urine, bile, and pancreatic juice. Each organ container is connected to the corresponding organ secretion duct (such as the bile duct that secretes bile) in each compartment of the multi-organ container 108 through a secretion outlet pipe that passes through the water bath 300.

[0027] A touch screen 105 is connected to a controller 200. The touch screen 105 outputs control signals to the controller and reads and displays the signals output by the controller. The controller 200 is connected to a peristaltic pump, an inlet flow control valve 107-1, an outlet flow control valve 107-2, and a temperature sensor. The controller 200 reads the signal from the temperature sensor and outputs a temperature control signal to the water bath 300 to heat the water in the water bath. The controller 200 reads the signals from the inlet flow control valve 107-1 and the outlet flow control valve 107-2, and then outputs a rotation control signal to the peristaltic pump.

[0028] In a preferred embodiment of the present invention, the trolley includes an upper platform 124 mounted on a trolley base plate. A handle 110 is fixed to the left side of the upper platform 124, and four wheels 114 are connected to the trolley base plate. A middle partition 121 and a right partition 122 are respectively installed in the middle and on the right side of the upper platform 124. Multiple drug pushers 101 (the number of drug pushers 101 can be determined according to actual needs) and an oxygen cylinder 102 are installed on the upper platform 124 to the right of the right partition 122. The oxygen cylinder 102 is fixed to the right partition 122 by an oxygen cylinder fixing strap 123 to ensure that the oxygen cylinder 102 is fixed in place. The peristaltic pump 116, the oxygenation device, and the filter 120 are arranged sequentially between the middle partition 121 and the right partition 122. The peristaltic pump 116 is fixed to the upper platform 124 and is clamped between the middle partition 121 and the right partition 122 to limit shaking. The oxygenation device 103 is suspended and fixedly connected to a U-shaped oxygenation device connecting plate 104. The two ends of the U-shape of the connecting plate are respectively fixed to the middle partition 121 and the right partition 122. The filter 120 is fixedly connected to the middle partition 121 via a filter bracket 118. The inlet flow control valve 107-1 is fixedly installed on the top surface of the middle partition 121. The water bath 300 is fixedly installed on the upper platform 124 on the left side of the middle partition 121. The organ secretion container 115 is installed on the upper platform 124 in front of the multi-organ container 108. The touch screen 105 is fixed to the rear side of the upper platform 124 via a touch screen connecting bracket 106.

[0029] The inlet flow control valve and the outlet flow control valve are either mechanical manual valves or electrically controlled valves.

[0030] Figure 1This is a schematic diagram of a multi-organ preservation device. Each organ is stored in a multi-organ container 108. Blood, powered by a peristaltic pump 116, enters an oxygenation device 103. Oxygen from an oxygen cylinder 102 enters the oxygenation device 116 and oxygenates the blood. After oxygenation, the blood flows into each organ. A drug delivery device 101 delivers medication or nutrients from the liver, which mix with the blood and enter the respective organs. The flow rate and volume of blood entering each organ are controlled by its respective inlet flow control valve 107-1. After passing through each organ, the blood returns to a filter 120. The return flow rate and pressure are regulated by an outlet flow control valve 107-2. Foam and impurities in the blood are filtered through the filter 120 before flowing back to the peristaltic pump 116. During use, pressure and flow sensors can be clamped onto the blood vessels flowing into various organs to measure pressure and flow rate, transmitting these measurements to the controller 200. Temperature signals from the water bath 300 are also connected to the controller 200 via sensors. The controller 200 adjusts the water temperature in the water bath 300 as needed, and simultaneously adjusts the rotation speed of the peristaltic pump 116 according to various parameters and the doctor's guidance. The doctor can configure the multi-organ preservation device and view the operational status information of each component via the touchscreen display 105.

[0031] The present invention and its embodiments have been described above illustratively. This description is not restrictive, and the accompanying drawings only show a few embodiments of the present invention. The actual structure is not limited to these embodiments. If those skilled in the art are inspired by this description and, without departing from the spirit of the present invention, adopt other forms of structure, transmission, installation, and connection methods that are similar to the technical solution without creative design, all such structures and embodiments should fall within the protection scope of the present invention.

Claims

1. A multi-organ preservation device, characterized in that, include: The trolley and the multi-organ preservation device mounted on the trolley; The aforementioned multi-organ preservation device includes: A water bath tank equipped with a temperature sensor is provided. A multi-organ container is placed inside the water bath tank. The multi-organ container has at least four compartments, each for holding different organs. The bottoms of each compartment are interconnected by pipes. There is a compartment outlet at the bottom of any compartment. The compartment outlet is connected to an outlet pipe. The outlet pipe passes through the multi-organ container and the water bath tank and is connected to an outlet main pipe. The outlet main pipe is sequentially connected to an outlet flow control valve, a filter, and a peristaltic pump inlet. The filtrate outlet of the filter is lower than the liquid level in the multi-organ container. The multi-organ container is covered with a container cover, and there is a sterile cover outside the container cover. The front and back sides of the container cover are sealed and fastened to the multi-organ container by two symmetrically arranged container cover buckles. The sterile cover is also tightly fastened to the multi-organ container by the sterile cover buckle. The outlet of the oxygenation device is connected to the main delivery pipe. The outlets of multiple drug pushers are connected to the main delivery pipe through drug delivery pipes. The main delivery pipe has multiple branches. Each branch is equipped with an inlet flow control valve. The outlet of each branch passes through the water bath and the multi-organ container and is connected to the tissues, organs, arteries and blood vessels in each tank of the multi-organ container. The outlet of an oxygen cylinder is connected to the inlet of the oxygenation device through an oxygen pipeline. The multi-organ preservation device includes at least three graduated organ secretion containers for collecting secretions. Each organ secretion container is connected to the corresponding secretion pipe of the organ in each compartment of the multi-organ container through a secretion outlet pipe passing through the water bath. The multi-organ preservation device includes a touch screen connected to a controller. The touch screen outputs control signals to the controller and reads and displays the signals output by the controller. The controller is connected to a peristaltic pump, an inlet flow control valve, an outlet flow control valve, and a temperature sensor. The controller reads the signal from the temperature sensor and outputs a temperature control signal to the water bath to heat the water in the water bath. The controller reads the signals from the inlet and outlet flow control valves and then outputs a rotation control signal to the peristaltic pump. The trolley includes an upper platform mounted on a flatbed. Four wheels are attached to the base of the trolley. A handle is fixed to the left side of the upper platform. A middle partition and a right partition are installed in the middle and right sides of the upper platform, respectively. Multiple drug delivery devices and oxygen cylinders are installed on the upper platform to the right of the right partition. The oxygen cylinders are fixed to the right partition by oxygen cylinder fixing straps. A peristaltic pump, an oxygenation device, and a filter are arranged sequentially between the middle partition and the right partition. The peristaltic pump is fixed to the upper platform and its movement is restricted by clamping the middle partition and the right partition. The oxygenation device is suspended and fixedly connected to a U-shaped oxygenation device connecting plate. The two ends of the U-shape of the oxygenation device connecting plate are fixed to the middle partition and the right partition, respectively. The filter is fixedly connected to the middle partition by a filter bracket. An inlet flow control valve is fixedly installed on the top surface of the middle partition. A water bath is fixedly installed on the upper platform to the left of the middle partition. An organ secretion container is installed on the upper platform in front of the multi-organ container. A touch screen is fixed to the rear of the upper platform by a touch screen connecting bracket.

2. The multi-organ preservation device according to claim 1, characterized in that, The inlet flow control valve and outlet flow control valve are mechanical manual valves.

3. The multi-organ preservation device according to claim 1, characterized in that, The inlet flow control valve and outlet flow control valve are electrically controlled valves.

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