A method for constructing a personalized multi-porous intervertebral fusion cage

Abstract

The present invention relates to the field of medical devices, and in particular to a method for constructing a personalized porous intervertebral fusion device. The present invention provides a method for constructing a personalized porous intervertebral fusion device model, comprising: constructing the upper end surface control points and the lower end surface control points of the fusion device based on the vertebral body three-dimensional model and multiple mid-plane control points on the mid-plane of the fusion device; constructing a fusion device body; constructing a bone grafting accommodating cavity; constructing an end surface mesh; constructing a bone grafting hole; constructing a clamping groove; and constructing a force belt. The method for constructing a personalized porous intervertebral fusion device model provided by the present invention is personalized through the mid-plane, and the intervertebral fusion device obtained by the construction can match the anatomical characteristics and physiological curvature requirements of different patients, and can promote the fusion of the upper and lower vertebrae. The elliptical pore structure on the upper and lower end surfaces of the fusion device can increase the contact area between the transplanted bone and the upper and lower end plates, and promote the growth of bone tissue.

Description

Technical Field

[0001] The present invention relates to the field of medical devices, and in particular to a method for constructing a personalized porous intervertebral fusion cage. Background Art

[0002] Intervertebral fusion is currently one of the main methods for treating lumbar degenerative diseases, and is commonly used to treat lumbar instability, lumbar spinal stenosis, degenerative spondylolisthesis, degenerative scoliosis, degenerative disc disease, etc. An ideal intervertebral fusion device should be able to correct spinal deformity, restore normal physiological curvature, maintain the stability of the intervertebral space, and most importantly, promote bone fusion.

[0003] In clinical surgery, the morphological design, material properties and implantation method of the intervertebral fusion device directly determine the effect of the fusion surgery. The intervertebral fusion devices currently produced in a standardized, batched and serialized manner on the market are difficult to match the personalized anatomical characteristics of different patients and the special needs of patients with different bone qualities, resulting in settlement, fatigue failure and non-fusion after the fusion device is implanted in the body. Summary of the invention

[0004] In view of the above-mentioned shortcomings of the prior art, an object of the present invention is to provide a method for constructing a personalized porous intervertebral fusion cage to solve the problems in the prior art.

[0005] To achieve the above objectives and other related objectives, the present invention provides, on one hand, a method for constructing a personalized porous intervertebral fusion cage model, comprising:

[0006] Based on the vertebral body three-dimensional model and multiple mid-plane control points on the mid-plane of the fusion device, the upper end surface control points and the lower end surface control points of the fusion device are constructed, wherein the mid-plane of the fusion device is located between the vertebrae, the upper end surface control points of the fusion device are the projections of the mid-plane control points on the lower end plate of the upper vertebrae, and the lower end surface control points of the fusion device are the projections of the mid-plane control points on the upper end plate of the lower vertebrae;

[0007] The fusion device body is constructed according to the control points of the upper end surface of the fusion device and the control points of the lower end surface of the fusion device;

[0008] Constructing a bone graft accommodating cavity, wherein the bone graft accommodating cavity is located in the middle of the fusion device body;

[0009] Constructing an end surface mesh, wherein the end surface mesh communicates the end surface of the fusion device body and the bone graft accommodating cavity;

[0010] Constructing a bone graft hole, wherein the bone graft hole communicates with the head surface of the fusion device body and the bone graft accommodating cavity;

[0011] Constructing a clamping groove, wherein the clamping groove is located at the tail of the fusion device body;

[0012] A stress-bearing belt is constructed and is located on the side wall surface of the rear end of the fusion device body.

[0013] In some embodiments of the present invention, the angle between the median plane and the upper endplate of the vertebral body is 0 to 15°, and the angle between the median plane and the lower endplate of the vertebral body is 0 to 15°;

[0014] And / or, the median surface of the fusion device includes a surface corresponding to the bone graft accommodating cavity, the bone graft accommodating cavity corresponding to the surface extending toward one side of the vertebral body to form a head entity portion, and the bone graft accommodating cavity corresponding to the surface extending toward the other side of the vertebral body to form a tail entity portion;

[0015] and / or, the edge of the median surface of the fusion device is 4.5 to 18.5 mm away from the center thereof;

[0016] And / or, the dimension of the median plane of the fusion device in the length direction is 22 to 36 mm, and the dimension in the width direction is 9 to 12 mm;

[0017] and / or, at least part of the mid-plane control points are located at the edge of the mid-plane of the fusion device, and the mid-plane control points are evenly distributed on the mid-plane of the fusion device;

[0018] And / or, the projection is a projection along the axial direction of the vertebral body.

[0019] In some embodiments of the present invention, the corresponding surface of the bone graft receiving cavity is a parallelogram with an inner acute angle of 70 to 80 degrees;

[0020] And / or, the corresponding surface of the head entity part is a fan-shaped surface, the distal end point of the corresponding surface of the head entity part is 11.2 to 18.5 mm away from the center of the middle surface of the fusion device, and the distal end of the head entity part is biased toward the rear side of the middle surface of the fusion device;

[0021] And / or, the corresponding surface of the tail entity part is a fan-shaped surface, the distal end point of the corresponding surface of the tail entity part is 11.2 to 18.5 mm away from the center of the middle surface of the fusion device, and the distal end of the tail entity part is biased toward the front side of the middle surface of the fusion device.

[0022] In some embodiments of the present invention, the method for constructing a fusion device body according to the control points of the upper end surface of the fusion device and the control points of the lower end surface of the fusion device specifically includes:

[0023] The upper end surface of the fusion device is obtained according to the control points of the upper end surface of the fusion device;

[0024] The lower end surface of the fusion device is obtained according to the control points of the lower end surface of the fusion device;

[0025] The side wall of the fusion device is constructed according to the control points of the upper end surface of the fusion device and the control points of the lower end surface of the fusion device;

[0026] Construct and obtain the fuser body.

[0027] In some embodiments of the present invention, the cavity of the bone graft accommodation cavity occupies 75-90% of the bone graft accommodation portion, and the wall thickness of the bone graft accommodation cavity is 1-2 mm;

[0028] And / or, the end surface mesh extends along the height direction of the fusion device;

[0029] And / or, the total hole area of ​​the upper end surface of the bone graft receiving portion is 3.125π~7.5πmm 2 The total hole area of ​​the lower end surface of the bone graft receiving portion is 3.125π~7.5πmm 2 ;

[0030] And / or, the single hole area of ​​the end surface mesh is 0.125π~1.125πmm 2 , pore diameter is 0.5~1.5mm;

[0031] And / or, further comprising: constructing a side wall mesh, wherein the side wall mesh connects the side wall surface of the fusion device body and the bone graft receiving cavity, wherein the side wall mesh extends along the width direction of the fusion device, and the total hole area of ​​the side wall mesh on one side of the bone graft receiving portion is 1.25π to 2.5π mm 2 , the single hole area of ​​the side wall mesh is 0.125π~1.125πmm 2 The aperture of the side wall mesh is 0.5~1.5mm.

[0032] In some embodiments of the present invention, the bone graft hole communicates with the side wall surface of the head of the fusion device body and the bone graft accommodating cavity;

[0033] And / or, the diameter of the bone graft hole is 2 to 3 mm;

[0034] And / or, the clamping groove is located on the side wall of the rear portion of the fusion device body.

[0035] Another aspect of the present invention provides a method for preparing a personalized porous intervertebral fusion device, the method comprising: preparing a personalized porous intervertebral fusion device by constructing a personalized porous intervertebral fusion device model obtained according to the method for constructing a personalized porous intervertebral fusion device model.

[0036] Another aspect of the present invention provides a personalized porous intervertebral fusion device, which is constructed by the construction method of the personalized porous intervertebral fusion device or prepared by the preparation method of the personalized porous intervertebral fusion device.

[0037] Another aspect of the present invention provides a computer-readable storage medium having a computer program stored thereon, which, when executed by a processor, implements the steps of the method for constructing a personalized porous intervertebral fusion cage model or the steps of the method for preparing a personalized porous intervertebral fusion cage.

[0038] On the other hand, the present invention provides a device, comprising: a processor and a memory, wherein the memory is used to store a computer program, and the processor is used to execute the computer program stored in the memory, so that the device performs the steps of the method for constructing a personalized porous intervertebral fusion cage model, or the steps of the method for preparing a personalized porous intervertebral fusion cage. BRIEF DESCRIPTION OF THE DRAWINGS

[0039] Figure 1 Shown is a three-dimensional schematic diagram of the overall structure of the present invention from a front view.

[0040] Figure 2 Shown is a three-dimensional schematic diagram from the bottom view of the overall structure of the present invention.

[0041] Figure 3 Shown is a schematic diagram of the relative position relationship of the control points of the mid-plane in Example 1 of the present invention.

[0042] Figure 4 It shows a schematic diagram of the morphology curves of the upper and lower end surfaces in Example 1 of the present invention.

[0043] Figure 5 Shown is the outline and solid schematic diagram of the initial hexahedron of the fusion device in Example 1 of the present invention.

[0044] Figure 6 Shown is a schematic diagram of the internal bone graft cavity in Example 1 of the present invention.

[0045] Figure 7 Shown is a wireframe schematic diagram of the elliptical porous structure in Example 1 of the present invention.

[0046] Figure 8 It is a schematic diagram showing the geometric relationship of the bottom surface of the rectangular parallelepiped of the tail clamping groove in Example 1 of the present invention.

[0047] Fig. 9 Shown is a schematic diagram of a physical model of a personalized porous intervertebral fusion cage in Example 1 of the present invention.

[0048] Fig.10 Shown is a schematic diagram of the relative position relationship between the personalized porous intervertebral fusion device of the present invention and the upper and lower vertebral bodies.

[0049] Fig.11 Shown is a schematic diagram of the distribution of the upper and lower end plates in Example 1 of the present invention.

[0050] Component number description

[0051] 1 Bone graft receiving area

[0052] 11 Bone graft receiving cavity

[0053] 12 End mesh

[0054] 13 side wall mesh

[0055] 2 Head body

[0056] 21 Bone graft hole

[0057] 3 Tail body

[0058] 31 Clamping slot

[0059] 32 Force belt

[0060] 4 Cavity

[0061] 5 Physical part DETAILED DESCRIPTION

[0062] After extensive practical research, the inventors of the present invention have provided a new method for constructing a personalized porous intervertebral fusion cage model. The constructed personalized porous intervertebral fusion cage model can effectively promote bone tissue growth, and the present invention was completed on this basis.

[0063] A first aspect of the present invention provides a method for constructing a personalized porous intervertebral fusion cage model, comprising:

[0064] S1) constructing an upper end surface control point and a lower end surface control point of a fusion device based on a vertebral body three-dimensional model and a plurality of mid-plane control points on a mid-plane of a fusion device, wherein the mid-plane of the fusion device is located between vertebrae, the upper end surface control point of the fusion device is a projection of the mid-plane control point on a lower end plate of an upper vertebra, and the lower end surface control point of the fusion device is a projection of the mid-plane control point on an upper end plate of a lower vertebra;

[0065] S2) constructing a fusion device body according to the control points of the upper end surface of the fusion device and the control points of the lower end surface of the fusion device;

[0066] S3) constructing a bone graft accommodating cavity, wherein the bone graft accommodating cavity is located in the middle of the fusion device body;

[0067] S4) constructing an end surface mesh, wherein the end surface mesh communicates with the end surface of the fusion device body and the bone graft accommodating cavity;

[0068] S5) constructing a bone graft hole, wherein the bone graft hole communicates with the head surface of the fusion device body and the bone graft accommodating cavity;

[0069] S6) constructing a clamping groove, wherein the clamping groove is located at the tail of the fusion device body;

[0070] S7) constructing a stress-bearing belt, wherein the stress-bearing belt is located on the side wall surface of the rear end of the fusion device body.

[0071] The method for constructing a personalized porous intervertebral fusion cage model provided by the present invention may include: constructing the upper end face control point and the lower end face control point of the fusion cage based on the vertebral body three-dimensional model and multiple mid-plane control points on the mid-plane of the fusion cage, wherein the mid-plane of the fusion cage is located between the vertebrae, the upper end face control point of the fusion cage is the projection of the mid-plane control point on the lower end plate of the upper vertebrae, and the lower end face control point of the fusion cage is the projection of the mid-plane control point on the upper end plate of the lower vertebrae. The projection may be a projection along the axis direction of the vertebrae. The vertebral body three-dimensional model can usually be obtained by importing CT data into software, such as Medraw, mimics, etc. The vertebral body three-dimensional model usually includes at least the upper vertebrae and the lower vertebrae involved in the fusion cage, and may also include one or more other vertebrae above the upper vertebrae of the fusion cage and / or one or more other vertebrae below the lower vertebrae. There is usually a certain gap between the vertebrae, and the mid-plane of the fusion cage is located between the upper vertebrae and the lower vertebrae, extending along the gap between the vertebrae. The lower endplate of the upper vertebral body usually matches the lower surface of the upper vertebral body, that is, it basically matches, and its shape is elliptical; for another example, the upper endplate of the lower vertebral body usually matches the upper surface of the lower vertebral body, that is, it basically matches, and its shape is elliptical; for another example, the angle between the median plane and the upper endplate of the vertebral body can be 0°~15°, and the angle between the median plane and the lower endplate of the vertebral body can be 0°~15°. When the angle is 0°, the two surfaces are parallel to each other. Since the upper endplate and the lower endplate are irregular curved surfaces, the distance between the projections of the control points on the fusion device on the upper and lower endplates also varies. Generally speaking, the difference between the maximum and minimum values ​​of the distance between the projections of each control point on the upper and lower endplates is no more than 4mm. The center plane of the fusion device can usually be determined based on the upper end plate and the lower end plate, and can usually be located between the two, with the ratio of the distance between the two being not less than 45-50% (i.e. the ratio between the closer distance and the farther distance), preferably not less than 60%, 70%, 80%, 90%, or 95%. The distance between the edge of the median surface of the fusion device and its center can be 4.5 to 18.5 mm, the size of the median surface of the fusion device in the length direction (i.e. corresponding to the left-right direction of the human body or the vertebral body) is 22 to 36 mm, and the size in the width direction (i.e. corresponding to the front-back direction of the human body or the vertebral body) is 9 to 12 mm. When determining the sizes in the length direction and the width direction, an axis can usually be determined in this direction, and the distance between the endpoints of the projections of the corresponding parts of the fusion device on the axis is used as the size distance. The center of the median surface of the fusion device is usually located in the middle of the vertebral cross section corresponding to the position of the median surface of the fusion device. For example, the center of the median surface of the fusion device can be close to or basically coincide with the center point of the vertebral cross section corresponding to the position of the median surface of the fusion device. For another example, it can be determined based on the center of the upper end plate and the center of the lower end plate, and specifically can be the midpoint of the two.The median surface of the fusion device may include a corresponding surface of the bone graft accommodating cavity, and may also include a corresponding surface of the head entity part and a corresponding surface of the tail entity part located on both sides of the corresponding surface of the bone graft accommodating cavity. The corresponding surface of the bone graft accommodating cavity extends to one side of the vertebral body to form the head entity part, and the corresponding surface of the bone graft accommodating cavity extends to the other side of the vertebral body to form the tail entity part. The corresponding surface of the head entity part, the corresponding surface of the bone graft accommodating cavity, and the corresponding surface of the tail entity part are usually arranged in sequence according to the length direction of the fusion device. For example, the corresponding surface of the bone graft accommodating cavity extends to the left side of the vertebral body to form the head entity part, and the corresponding surface of the bone graft accommodating cavity extends to the right side of the vertebral body to form the tail entity part. In a specific embodiment of the present invention, the corresponding surface of the bone graft accommodating cavity is a parallelogram with an inner acute angle of 70 to 80°. Two sides of the parallelogram are consistent with the length direction of the median surface of the fusion device. Its length direction size is 12 to 24.75 mm, and its width direction size is 9 to 12 mm. In another specific embodiment of the present invention, the distal end of the head entity part is biased toward the rear side of the middle plane of the fusion device (i.e., the side close to the back of the human body), the corresponding surface of the head entity part is a fan surface, and the distal end point of the corresponding surface of the head entity part (i.e., the point at which the edge of the corresponding surface of the head entity part is farthest from the middle plane of the fusion device) is 11.2 to 18.5 mm away from the center of the middle plane of the fusion device. In another specific embodiment of the present invention, the distal end of the tail entity part is biased toward the front side of the middle plane of the fusion device (i.e., the side close to the chest and abdomen of the human body), the corresponding surface of the tail entity part is a fan surface, and the distal end point of the corresponding surface of the tail entity part (i.e., the point at which the edge of the corresponding surface of the tail entity part is farthest from the middle plane of the fusion device) is 11.2 to 18.5 mm away from the center of the middle plane of the fusion device. The middle plane control points can usually be evenly distributed on the middle plane of the fusion device, so that the shape of the upper and lower end surfaces can be better reflected. At least part of the middle plane control points are located at the edge of the middle plane of the fusion device, so that the side walls and end surfaces of the fusion device can be effectively constructed. In a specific embodiment of the present invention, at least one control point is provided at the center of the median surface of the fusion device, and more than eight control points are evenly distributed at the edge of the median surface of the fusion device.

[0072] The method for constructing a personalized porous intervertebral fusion cage model provided by the present invention may include: constructing a fusion cage body according to the control points of the upper end surface of the fusion cage and the control points of the lower end surface of the fusion cage. After obtaining the control points of the upper end surface of the fusion cage and the control points of the lower end surface of the fusion cage, the fusion cage body can be constructed according to each control point. For example, the method for constructing a fusion cage body according to the control points of the upper end surface of the fusion cage and the control points of the lower end surface of the fusion cage specifically includes: constructing an upper end surface of the fusion cage according to the control points of the upper end surface of the fusion cage; constructing an lower end surface of the fusion cage according to the control points of the lower end surface of the fusion cage; constructing a side wall of the fusion cage according to the control points of the upper end surface of the fusion cage and the control points of the lower end surface of the fusion cage; constructing a fusion cage body. In a specific embodiment of the present invention, a Bezier curve can be constructed according to the control points of the upper end surface of the fusion cage and the tangent vector, and the upper end surface of the fusion cage can be constructed by curve lofting. In another specific embodiment of the present invention, a Bezier curve can be constructed according to the control points of the lower end surface of the fusion cage and the tangent vector, and the lower end surface of the fusion cage can be constructed by curve lofting. In another specific embodiment of the present invention, the side wall of the fusion device can be constructed by segmenting the curves according to the corresponding upper end surface control points and lower end surface control points of the fusion device. The fusion device body can be cylindrical, and the height of the fusion device body (corresponding to the dimension in the axial direction of the vertebral body) can be 6 to 18 mm.

[0073] The method for constructing a personalized porous intervertebral fusion cage model provided by the present invention may include: constructing a bone graft accommodating cavity, wherein the bone graft accommodating cavity is located in the middle of the cage body. The bone graft accommodating cavity is usually used to store bone graft materials (for example, can be cancellous bone mud, bone fragments, etc.), so as to promote postoperative bone ingrowth and vertebral fusion. The bone graft accommodating cavity is usually located in the middle of the cage body, and more specifically can be located in the bone graft accommodating portion of the cage body (i.e., the portion of the cage body corresponding to the corresponding surface of the bone graft accommodating cavity). The bone graft accommodating cavity is usually evenly distributed in the bone graft accommodating portion of the cage body, and its cavity size can account for 75-90% of the bone graft accommodating portion. The wall thickness of the bone graft accommodating cavity (usually refers to the wall thickness of the bone graft accommodating cavity in the width direction) can be 1-2 mm.

[0074] The method for constructing a personalized porous intervertebral fusion cage model provided by the present invention may include: constructing an end face mesh, wherein the end face mesh connects the end face of the fusion cage body and the bone graft accommodating cavity, and more specifically, the end face of the bone graft accommodating portion of the fusion cage body and the bone graft accommodating cavity, thereby ensuring that bone tissue can grow through the end face mesh. The end face mesh usually extends along the height direction of the fusion cage (i.e., the axial direction of the corresponding vertebral body), and the total hole area of ​​the upper end face of the bone graft accommodating portion can be 3.125π~7.5πmm 2 The total hole area of ​​the lower end surface of the bone graft receiving portion can be 3.125π~7.5πmm 2, thereby promoting bone tissue growth. In a specific embodiment of the present invention, the single hole area of ​​the end surface mesh can be 0.125π~1.125πmm 2 The pore size can be 0.5 to 1.5 mm, thereby ensuring bone tissue growth while avoiding leakage of implanted materials during or after surgery.

[0075] The method for constructing a personalized porous intervertebral fusion cage model provided by the present invention may also include: constructing a side wall mesh, wherein the side wall mesh connects the side wall surface of the fusion cage body and the bone graft receiving cavity, thereby promoting bone ingrowth in the later stage of fusion cage implantation. The side wall mesh extends along the width direction of the fusion cage, and the total hole area of ​​the side wall mesh on one side of the bone graft receiving portion can be 1.25π to 2.5πmm 2 The single hole area of ​​the side wall mesh can be 0.125π~1.125πmm 2 The pore size of the side wall mesh can be 0.5 to 1.5 mm, which can promote bone tissue growth.

[0076] The method for constructing a personalized porous intervertebral fusion device model provided by the present invention may include: constructing a bone graft hole, wherein the bone graft hole connects the surface of the head of the device body and the bone graft accommodating cavity. More specifically, the bone graft hole can connect the side wall surface of the head of the device body and the bone graft accommodating cavity, so that the bone graft material can be filled into the bone graft accommodating cavity. The personalized porous intervertebral fusion device extends in the length direction, that is, corresponds to the left-right direction of the human body or vertebral body, so that it can facilitate filling while avoiding leakage of implanted materials during or after surgery. In a specific embodiment of the present invention, the aperture of the bone graft hole can be 2 to 3 mm.

[0077] The method for constructing a personalized porous intervertebral fusion cage model provided by the present invention may include: constructing a clamping groove, wherein the clamping groove is located at the tail of the cage body, so as to facilitate clamping and placement of the cage during surgery. In a specific embodiment of the present invention, the clamping groove is located on the side wall of the tail of the cage body.

[0078] The method for constructing a personalized porous intervertebral fusion cage model provided by the present invention may include: constructing a force belt, wherein the force belt is located on the side wall surface of the tail of the fusion cage body, so as to increase the force area and facilitate the application of a certain external force to the fusion cage during surgery to adjust the position of the fusion cage, for example, the fusion cage can be tapped. In a specific embodiment of the present invention, the force belt is located on the side wall of the tail of the fusion cage body. In another specific embodiment of the present invention, the force belt is a rough surface, more specifically, it can be a stripe pattern, etc.

[0079] The second aspect of the present invention provides a method for preparing a personalized porous intervertebral fusion device, the method comprising: preparing a personalized porous intervertebral fusion device using a personalized porous intervertebral fusion device model constructed according to the method for constructing a personalized porous intervertebral fusion device model provided by the first aspect of the present invention. The method for preparing a personalized porous intervertebral fusion device using a personalized porous intervertebral fusion device model constructed according to the method for constructing a personalized porous intervertebral fusion device model should be known to those skilled in the art. For example, 3D printing and other methods may be used, and the materials used may be polymer materials (for example, PEEK polyetheretherketone materials, etc.) or metal materials (for example, titanium alloy (Ti-6Al-4v)), etc.

[0080] The third aspect of the present invention provides a personalized porous intervertebral fusion device, which is constructed by the construction method of the personalized porous intervertebral fusion device provided by the first aspect of the present invention, or prepared by the preparation method of the personalized porous intervertebral fusion device provided by the second aspect of the present invention.

[0081] like Figure 1 , Figure 2 As shown, the present invention provides a personalized porous intervertebral fusion device, including a fusion device body, the fusion device body includes a bone graft accommodating portion 1, the bone graft accommodating portion 1 usually corresponds to the central part of the vertebral body, the bone graft accommodating portion 1 is provided with a head entity portion 2 and a tail entity portion 3 on both sides, respectively corresponding to the two sides of the center of the vertebral body, the bone graft accommodating portion 1 is provided with a bone graft accommodating cavity 11, the cavity of the bone graft accommodating cavity 11 can account for 75-90% of the bone graft accommodating portion 1, the wall thickness of the bone graft accommodating cavity 11 (usually refers to the width of the bone graft accommodating cavity 11) The upward wall thickness) can be 1-2 mm, which is used to accommodate bone grafting materials. The upper end face and the lower end face of the bone grafting accommodating part 1 are provided with end face meshes 12, and the end face meshes 12 connect the end face of the bone grafting accommodating part 1 and the bone grafting accommodating cavity 11, so as to facilitate the growth of bone grafting materials with surrounding bone tissue. It also includes a bone grafting hole 21, and the bone grafting hole 21 connects the head surface of the fusion device body and the bone grafting accommodating cavity 11 to facilitate filling of bone grafting materials. The tail entity part 3 is provided with a clamping groove 31 and a force belt 32, so as to facilitate the position adjustment of the fusion device during surgery.

[0082] In the personalized porous intervertebral fusion device provided by the present invention, the end surface mesh 12 can extend along the height direction of the fusion device, and more specifically can be connected to the end surface of the bone graft receiving part 1 of the fusion device body and the bone graft receiving cavity 11, so as to ensure that bone tissue can grow through the end surface mesh 12. The single hole area of ​​the end surface mesh 12 can be 0.125π~1.125πmm 2 The hole diameter can be 0.5-1.5 mm, and the total hole area of ​​the upper end surface of the bone graft receiving portion 1 can be 3.125π-7.5πmm 2The total hole area of ​​the lower end surface of the bone graft receiving portion 1 can be 3.125π~7.5πmm 2 , thereby ensuring the growth of bone tissue while avoiding the leakage of implanted materials during or after surgery, and ensuring the promotion of bone tissue growth.

[0083] The personalized porous intervertebral fusion device provided by the present invention may further include a side wall mesh 13, wherein the side wall mesh 13 may connect the side wall surface of the bone graft receiving portion 1 and the bone graft receiving cavity 11, and the side wall mesh 13 may extend along the width direction of the fusion device, and the total hole area of ​​the unilateral side wall mesh 13 of the bone graft receiving portion 1 may be 1.25π~2.5πmm 2 The single hole area of ​​the side wall mesh 13 can be 0.125π~1.125πmm 2 The pore size of the side wall mesh 13 can be 0.5-1.5 mm, thereby promoting the growth of bone tissue.

[0084] In the personalized porous intervertebral fusion device provided by the present invention, the bone grafting hole 21 can connect the side wall surface of the head of the fusion device body and the bone grafting accommodating cavity 11. The bone grafting hole 21 can extend along the length direction of the personalized porous intervertebral fusion device, that is, corresponding to the left and right direction of the human body or the vertebral body. The aperture of the bone grafting hole 21 can be 2 to 3 mm, so as to facilitate filling while avoiding leakage of the implanted material during or after the operation.

[0085] In the personalized porous intervertebral fusion device provided by the present invention, the clamping groove 31 can be located on the side wall of the tail entity part 3, so that the device can be clamped and placed conveniently during surgery. The force belt 32 can be located on the side wall of the tail entity part 3, and the force belt 32 can be a rough surface. The force belt 32 can be located on the side wall surface of the tail of the device body, so that the force area can be increased, which is convenient for applying a certain external force to the device during surgery, so as to adjust the position of the device, for example, the device can be knocked. In another specific embodiment of the present invention, the force belt 32 is a rough surface, and more specifically can be a stripe pattern or the like.

[0086] In the personalized porous intervertebral fusion device provided by the present invention, the personalized porous intervertebral fusion device can be cylindrical, and its height can be 6 to 18 mm. The cross section of the personalized porous intervertebral fusion device (i.e., the cross section perpendicular to the vertebral body axis) can include a corresponding surface of the bone graft accommodating cavity 11, and can also include a corresponding surface of the head entity part 2 and a corresponding surface of the tail entity part 3 located on both sides of the corresponding surface of the bone graft accommodating cavity 11. In a specific embodiment of the present invention, the corresponding surface of the bone graft accommodating cavity 11 is a parallelogram with an inner acute angle of 70 to 80°, and its length direction (consistent with the length direction of the personalized porous intervertebral fusion device) is 12 to 24.75 mm, and its width direction (consistent with the width direction of the personalized porous intervertebral fusion device) is 9 to 12 mm. In another specific embodiment of the present invention, the corresponding surface of the head entity part 2 is a fan surface, and the distal end point of the corresponding surface of the head entity part 2 is 11.2 to 18.5 mm away from the center of the median surface of the fusion device, and the distal end of the corresponding surface of the head entity part 2 is biased toward the rear side of the median surface of the fusion device. In another specific embodiment of the present invention, the corresponding surface of the tail entity part 3 is a fan surface, the distal end point of the corresponding surface of the tail entity part 3 is 11.2 to 18.5 mm away from the center of the middle surface of the fusion device, and the distal end of the corresponding surface of the tail entity part 3 is biased toward the front side of the middle surface of the fusion device.

[0087] A fourth aspect of the present invention provides a computer-readable storage medium having a computer program stored thereon, which, when executed by a processor, implements the steps of the method for constructing a personalized porous intervertebral fusion cage model provided in the first aspect of the present invention, or the steps of the method for preparing a personalized porous intervertebral fusion cage provided in the second aspect of the present invention.

[0088] The fifth aspect of the present invention provides a device, comprising: a processor and a memory, wherein the memory is used to store a computer program, and the processor is used to execute the computer program stored in the memory, so that the device performs the steps of the method for constructing a personalized porous intervertebral fusion cage model provided in the first aspect of the present invention, or the steps of the method for preparing a personalized porous intervertebral fusion cage provided in the second aspect of the present invention.

[0089] The construction method of the personalized porous intervertebral fusion cage model provided by the present invention is personalized through the median plane. The intervertebral fusion cage obtained by the construction can match the anatomical characteristics and physiological curvature requirements of different patients, so that each patient can receive more personalized medical services, and can promote the fusion of the upper and lower vertebrae. The elliptical pore structure on the upper and lower end surfaces of the fusion cage can increase the contact area between the transplanted bone and the upper and lower end plates, and promote the growth of bone tissue. In addition, the construction method provided by the present invention can greatly shorten the construction cycle, and can shorten the 8-14-day cycle to a standard individualized 3-6 days. Specifically, the construction method avoids standardizing the design process of traditional individualized customized instruments, shortens the 1-2 days of traditional CAD design (including the confirmation time with the doctor) to less than 15 minutes, and because the individualized customized instrument is composed of patient data parameters, the matching of the instrument does not need to be verified by matching the patient resin model with the instrument, which greatly shortens the experimental cycle, and at the same time improves the traditional production process (printing adapter film, CNC processing, etc.) to 3D printing (additive manufacturing), greatly shortening the production time and reducing the waiting time of patients.

[0090] The following describes the embodiments of the present invention through specific examples, and those skilled in the art can easily understand other advantages and effects of the present invention from the contents disclosed in this specification. The present invention can also be implemented or applied through other different specific embodiments, and the details in this specification can also be modified or changed in various ways based on different viewpoints and applications without departing from the spirit of the present invention.

[0091] Example 1

[0092] 1. Construction of the outer frame of the intervertebral fusion cage:

[0093] 1. Determination of the intervertebral fusion cage coordinate system

[0094] First, an ellipse is fitted based on the upper and lower endplates (see Fig.11 The coordinate system of the intervertebral fusion device is established by using the coordinate system of the upper and lower end plates (the left side is the upper end plate and the right side is the lower end plate). The origin of the coordinate system is the midpoint of the line connecting the centers of the fitted ellipses of the upper and lower end plates. The left and right (x-axis direction), front and back (y-axis direction), and up and down (z-axis direction) directions of the coordinate system are the average directions of the upper end plate coordinate system and the lower end plate coordinate system. The implantation direction of the fusion device (head) is the positive direction of the x-axis, the posterior direction of the human body is the positive direction of the y-axis, and the upper direction of the human body is the positive direction of the z-axis.

[0095] 2. Determination of the length and width of the intervertebral fusion cage

[0096] According to the morphological measurement of the intervertebral anatomical structure, the length and width of the fusion cage are adjusted and determined. The length is defined as the maximum distance in the x-axis direction, which is 36mm (range 22-36mm), recorded as l, and the half length is recorded as hl; the width is defined as the maximum distance in the y-axis direction, which is 12mm (range 9-12mm), recorded as w, and the half width is recorded as hw. The corresponding surface of the head entity is the fan surface, and the shape of the distal fan surface is a combination of two parts, the upper part is a parabola x=y 2 The first quadrant part of the tail is a quarter ellipse (the major axis of the ellipse is half the width, and the minor axis of the ellipse is 0.5 half the width). The corresponding surface of the tail solid part is a fan surface. The shape of the distal fan surface is a combination of the two parts. The upper part is a quarter ellipse (the major axis of the ellipse is half the width, and the minor axis of the ellipse is 0.5 half the width), and the lower part is a parabola x=-y 2 The third quadrant part.

[0097] 3. Calculate the coordinates of the 3×3 lattice of the median plane

[0098] The coordinates of the 3×3 sampling control point array (P1 to P9) of the mid-plane are calculated by the coordinate origin, coordinate system, and set length and width of the fuser. The calculation formula is as follows: Tan (α) = 0.5hw / 2hw = 0.25

[0099] The relative position relationship of the control points of the mid-plane is as follows: Figure 3 As shown in Table 1:

[0100] Table 1

[0101]

[0102]

[0103] Specific values ​​and ranges of the embodiments:

[0104]

[0105] 4. Construct the coordinates of the curve control points, tangent vectors, and forward and backward curves of the upper and lower end faces

[0106] The 3×3 control point matrix of the mid-plane is projected onto the upper and lower end plates according to the z-axis direction of the fusion device, and 18 control points (N1-N9, M1-M9) of the upper and lower end surfaces of the fusion device are obtained. The distances between the nine pairs of corresponding points on the upper and lower end surfaces are calculated, and the maximum distance is recorded as the maximum height, recorded as hmax, and the minimum distance is recorded as the minimum height, recorded as hmin (hmax in this embodiment is 8.0 mm and hmin is 6.1 mm). Control hmax and hmin within the height range, and this height range is 6-18 mm.

[0107] The shape of the curve is controlled by defining the tangent vectors of the upper and lower end faces and the mid-plane control points.

[0108] Table 2

[0109]

[0110]

[0111] The Bezier curve is constructed by 3×3 sampling control points and tangent vectors on each surface of the upper and lower end surfaces and the middle surface to form the morphological curves of the upper and lower end surfaces and the middle surface, such as Figure 4 shown.

[0112] 5. Based on the above curves, construct the upper and lower surfaces, the median surface, the front and rear surfaces, and the left and right surfaces to build the entity

[0113] Based on the above-mentioned upper and lower end surface morphology curves, the upper and lower surfaces, front and back surfaces, and left and right surfaces are constructed by segmenting. At the same time, the median surface curve is lofted to obtain the median surface, and the area ratio of the median surface to the area of ​​the lower end plate fitting ellipse is calculated as a reference for the design of the fusion cage. Finally, the initial six surfaces of the intervertebral fusion cage are sutured to construct the initial six-sided entity, such as Figure 5 shown.

[0114] 2. Construction of internal bone graft cavity, bone graft hole and elliptical mesh

[0115] 1. Construction of the internal bone graft cavity

[0116] The fixed-point coordinates of the internal bone graft cavity are calculated by setting the thickness of the fusion device. The thickness is recorded as th (1.0mm) and the range is 1.0mm to 1.5mm. The thickness set in this way is used as offset, and the initial six-sided entity is retracted inward by one thickness to obtain an offset entity. At the same time, the coordinates of the inner cavity point Q1, Q2, Q3, and Q4 with a thickness difference are calculated on the median plane through the coordinates of P1, P3, P7, and P9. The Q1Q2 line is parallel to the P1P3 line and the distance is equal to the thickness, the Q3Q4 line is parallel to the P7P9 line and the distance is equal to the thickness, the Q1Q3 line is parallel to the P1P7 line and the distance is equal to the thickness, and the Q2Q4 line is parallel to the P3P9 line and the distance is equal to the thickness. The bottom point of the quadrangular prism is obtained by translating Q1 to Q4 in the negative direction of the z-axis by a distance of hmax, and connected into a parallelogram as the bottom of the quadrangular prism. The height of the quadrangular prism is 2hmax (16.0mm) and the range is 12 to 36mm. The quadrangular prism entity is Boolean intersected with the offset entity to obtain the entity structure of the internal bone graft cavity. Then, the initial hexahedron is Boolean subtracted from the bone graft cavity entity to obtain the internal bone graft cavity. Specifically, Figure 6 In this way, except for the bone graft cavity in the middle (which can control the length and width and keep the shape of the internal cavity similar to the outer shell), the head and tail are both solid structures, which can provide better support.

[0117] 2. Construction of bone graft holes in the head

[0118] From the origin of the fusion device coordinate system as the center, construct a circle with a radius of 1.1mm (range 1.0-1.5mm) on the ZOY plane, and stretch the circle into a cylinder in the positive direction of the coordinate system x-axis. The length of the cylinder is 0.5l+1mm (0.5 length + 1mm) (19mm, range 12-19mm). Use Boolean subtraction between the fusion device entity and the cylinder entity to obtain the fusion device entity for the head bone graft hole.

[0119] 3. Construction of an elliptical porous structure (increasing the contact surface between the bone in the internal cavity and the upper and lower end plates to promote bone ingrowth)

[0120] Set the major axis (aperture) of the elliptical mesh, denoted by rx (1.0mm), ranging from 0.5mm to 1.5mm; the minor axis of the ellipse is defined as half of the major axis, denoted by ry (0.5mm), ranging from 0.25mm to 0.75mm; the hole spacing is the minimum distance between two adjacent ellipses, denoted by s (1.0mm), ranging from 0.5mm to 1.0mm. The degree of arctan (0.25) controls the central axis of the elliptical array to be parallel to the left and right end surfaces of the cavity. With the origin of the fusion device coordinate system as the center, construct an elliptical array on the midplane, and calculate how many complete elliptical meshes can be accommodated on the upper and lower surfaces of the cavity, such as Figure 7 As shown in the figure, the elliptical surface is swept upward and downward by a maximum height to construct an elliptical cylinder entity, and a series of elliptical cylinder entities are combined to form an elliptical cylinder entity array. Then, it is Boolean subtracted from the fusion device entity to obtain a fusion device entity with a porous structure.

[0121] The elliptical mesh on the front and back surfaces takes the intersection of the green dotted line and the front and back surfaces as the center. Similarly, the cylindrical entity is constructed and Boolean subtraction is performed with the fuser.

[0122] 3. Construction of clamping grooves and percussion bands related to the surgical process

[0123] 1. Construction of the tail surgical clamping groove (for clamping and placing surgical instruments)

[0124] Two cuboids are constructed at the tail of the fusion device. The bottom of the cuboid is shown as the green dotted frame. The coordinates of the upper right corner vertices B1 and B2 of the bottom of the two cuboids in the fusion device coordinate system are B1[-(hl+1)(range: -19 to -12),-(1.25hw+1)(range: -8.5 to -7.75),-(1.1)(constant value)](B1[-19,-8.5,-1.1]), B2[-(hl+1)(range: -19 to -12),3-0.25hw(range: 1.5 to 1.875),-(1.1)(constant value)](B2[-19,1.5,-1.1]). Set the length of the cuboid to (hw-th+1)mm (th is thickness) (6mm, range 4-6mm), the width of the cuboid to (hw-2)mm (4mm, range 2.5-4mm), and the height of the cuboid to 2.2mm (in order to match a specific clamping device, the height of the rectangle is a fixed value). Based on this vertex, the set length, width, height and direction (x-axis positive, y-axis positive, z-axis positive), construct two rectangular entities, and perform Boolean subtraction with the fusion device entity to obtain a clamping groove structure that matches the clamping device during surgery, such as Figure 8 shown.

[0125] 2. Construction of the stepped percussion belt at the tail

[0126] The center of the cylinder is on the part of the tail curve without the clamping groove, and the two parts of the curve separated by the clamping groove are counted separately. The number of cylinders is qfloor(curvelength / 0.9) (10 in the embodiment, ranging from 8 to 14). Here, 0.9mm is a set unit length (approximately equal to the diameter of a cylinder + the interval on the left and right sides), and the curve length / 0.9 is rounded down to get the maximum number of cylinders that can be accommodated.

[0127] The radius of the cylinder is r = curvelength / number (0.95mm, range 0.8-1.0mm), and the height of the cylinder is 0.8 times the distance between the upper and lower end surface boundary lines (range 4.8-14.4mm). Construct a series of cylinder entities, and then add them to the fusion device entity to obtain the final fusion device entity, such as Fig. 9 As shown. The fusion device is finally saved in STL file or STEP file format and printed using SLM selective laser melting metal 3D printing technology, with the material being Ti-6Al-4v titanium alloy.

[0128] Example 2

[0129] like Fig.10As shown in the figure, the constructed fusion device is used for posterior lumbar intervertebral fusion surgery (TLIF), and is equipped with corresponding fusion device clamping and implantation instruments. First, after the pedicle screw is inserted, the intervertebral disc is removed; after the intervertebral space is reduced, the cancellous bone mud or bone fragments are implanted into the fusion device through the head bone graft hole, and finally the fusion device is placed in the intervertebral space from the posterior lumbar spine. A total of 50 cases underwent TLIF surgery, and the five main height measurements (center, front, back, left, and right) of the individualized and traditional fusion devices were performed after surgery to reflect the degree of intervertebral morphological matching. The specific data are shown in Table 1:

[0130] Table 1

[0131]

[0132]

[0133] As shown in Table 1, the measurement results show that the intervertebral height difference in the area where the fusion device is located is roughly in the range of 0.5 to 4.5 mm, while the height of the traditional intervertebral fusion device is uniform, which makes it difficult to match the different intervertebral morphologies of patients and cannot achieve individualized treatment. However, the height of the individualized intervertebral fusion device can match the different intervertebral morphologies of any patient as much as possible. The height difference range of our individualized intervertebral fusion device is 0 to 4 mm, which can meet 94% (47 / 50×100%=94%) of the intervertebral height difference and better maintain the physiological curvature of the lumbar spine after surgery.

[0134] It can be seen that the fusion device is easy to implant during surgery, and its Z-shaped front end arc design makes it easy to adjust the forward direction of the fusion device during implantation, which is convenient for operation; the bone grafting part inside the fusion device uses a porous mesh structure to ensure that the bone will not fall off during the implantation of the fusion device, while at the same time ensuring effective contact between the upper and lower end plates and the bone grafting components, promoting bony fusion within 3 months after surgery and ensuring reliable fusion effect; the personalized anatomical matching of the fusion device has incorporated the overall force line factor in the design, and after implantation, it can achieve the restoration of the physiological lordosis (force line) of the lumbar spine; and the reliable fusion effect can prevent the long-term settlement of the fusion device; the anatomical matching greatly improves the contact part between the fusion device and the upper and lower end plates, meeting the ability to have immediate stability after surgery.

[0135] In summary, the present invention effectively overcomes various shortcomings of the prior art and has high industrial utilization value.

[0136] The above embodiments are merely illustrative of the principles and effects of the present invention, and are not intended to limit the present invention. Anyone familiar with the art may modify or alter the above embodiments without departing from the spirit and scope of the present invention. Therefore, all equivalent modifications or alterations made by a person of ordinary skill in the art without departing from the spirit and technical concept disclosed by the present invention shall still be covered by the claims of the present invention.

Claims

1. A method for constructing a personalized porous intervertebral fusion cage model, comprising: 1) Based on the vertebral body three-dimensional model and multiple mid-plane control points on the mid-plane of the fusion device, construct the upper end surface control points and the lower end surface control points of the fusion device, the mid-plane of the fusion device is located between the vertebrae, the upper end surface control points of the fusion device are the projections of the mid-plane control points on the lower end plate of the upper vertebrae, and the lower end surface control points of the fusion device are the projections of the mid-plane control points on the upper end plate of the lower vertebrae, and the fusion device entity is constructed according to the upper end surface control points and the lower end surface control points of the fusion device; 1-1) Determine the coordinate system of the fusion device; the origin of the coordinate system is the midpoint of the line connecting the centers of the upper and lower endplate fitting ellipses, and the left-right, front-back, and up-down directions of the coordinate system are the average directions of the upper endplate coordinate system and the lower endplate coordinate system; 1-2) Determine the length and width of the fusion device: the length of the fusion device is in the range of 22 to 36 mm, and the width of the fusion device is in the range of 9 to 12 mm; 1-3) Calculating the coordinates of the 3×3 lattice of the median plane: Calculating the coordinates of the 3×3 sampling control lattice of the median plane according to the coordinate origin, coordinate system, length and width of the fuser; 1-4) Constructing the coordinates of the curve control points, tangent vectors, and anterior-posterior curves of the upper and lower end surfaces: projecting the 3×3 control point matrix of the midplane onto the upper and lower end plates in the upper and lower directions of the fusion device, respectively, to obtain 18 control points of the upper and lower end surfaces of the fusion device; calculating the distances between the nine pairs of corresponding points on the upper and lower end surfaces, the distance range being 6 to 18 mm; 1-5) constructing the upper and lower surfaces, the median surface, the front and rear surfaces, and the left and right surfaces based on the above curves to construct the entity: constructing the upper and lower surfaces, the front and rear surfaces, and the left and right surfaces based on the above upper and lower end surface morphology curves in sections, and at the same time obtaining the median surface by lofting the median surface curve, and calculating the ratio of the area of ​​the median surface to the area of ​​the lower end plate fitting ellipse; finally, suturing the initial six surfaces of the fusion device together to construct an initial hexahedron; 2) Construction of internal bone graft cavity, bone graft hole and elliptical mesh; 2-1) Constructing an internal bone grafting cavity: setting the thickness of the fusion device, the thickness range is 1.0mm to 1.5mm; using this thickness as an offset, shrinking the initial hexahedron inward by a thickness to obtain an offset entity; at the same time, calculating an inner cavity point with a thickness difference on the median plane through the median plane 3×3 lattice coordinates; constructing a quadrangular prism from the above inner cavity point, the height range of the quadrangular prism is 12 to 36mm; performing Boolean intersection of the quadrangular prism entity and the offset entity to obtain the entity structure of the internal bone grafting cavity, and then performing Boolean subtraction of the initial hexahedron and the entity structure of the internal bone grafting cavity to obtain the internal bone grafting cavity; the internal bone grafting cavity is located in the middle of the fusion device body; 2-2) Constructing a bone graft hole: construct a circle with a radius range of 1.0 to 1.5 mm, and stretch the circle into a cylinder, wherein the height of the cylinder ranges from 12 to 19 mm; use Boolean subtraction between the fusion device entity and the cylinder entity to obtain the fusion device entity of the head bone graft hole, wherein the bone graft hole connects the head surface of the fusion device body and the bone graft accommodating cavity; 2-3) Constructing the end surface mesh: setting the major axis and minor axis of the end surface mesh, the major axis range is 0.5-1.5 mm, the minor axis range is 0.25-0.75 mm, and the hole spacing range is 0.5-1.0 mm; arraying multiple end surface meshes, and stretching all the end surface meshes into entities, and then performing Boolean subtraction of all the above entities from the fusion device entity to obtain a fusion device entity with a porous structure; the end surface mesh connects the end surface of the fusion device entity and the internal bone graft receiving cavity; 3) Construction of clamping grooves and percussion bands related to the surgical procedure; 3-1) Constructing a clamping groove: construct two cuboids at the tail of the fusion device entity, and perform Boolean subtraction with the fusion device entity to obtain a clamping groove structure that matches the holding instrument during surgery; the length of the cuboid is 4 to 6 mm, the width of the cuboid is 2.5 to 4 mm, and the height of the cuboid is 2.2 mm; 3-2) Constructing a stress belt: constructing a series of cylinders on the side wall of the tail of the fusion device body, and adding them to the fusion device entity to obtain a final fusion device entity; the center of each cylindrical entity is on the portion of the curve at the tail of the fusion device entity without a clamping groove; the number of the cylindrical entities is 8 to 14, the radius of the cylindrical entity is 0.8 to 1.0 mm, and the height of the cylindrical entity is 4.8 to 14.4 mm.

2. The construction method according to claim 1, characterized in that: The angle between the median plane and the upper endplate of the vertebral body is 0 to 15°, and the angle between the median plane and the lower endplate of the vertebral body is 0 to 15°; And / or, the median surface of the fusion device includes a surface corresponding to the bone graft accommodating cavity, the bone graft accommodating cavity corresponding to the surface extending toward one side of the vertebral body to form a head entity portion, and the bone graft accommodating cavity corresponding to the surface extending toward the other side of the vertebral body to form a tail entity portion; and / or, the edge of the median surface of the fusion device is 4.5 to 18.5 mm away from the center thereof; and / or, at least part of the mid-plane control points are located at the edge of the mid-plane of the fusion device, and the mid-plane control points are evenly distributed on the mid-plane of the fusion device; And / or, the projection is a projection along the axial direction of the vertebral body.

3. The construction method according to claim 2, characterized in that: The corresponding surface of the internal bone graft accommodating cavity is a parallelogram with an inner acute angle of 70 to 80 degrees; And / or, the corresponding surface of the head entity part is a fan-shaped surface, the distal end point of the corresponding surface of the head entity part is 11.2 to 18.5 mm away from the center of the middle surface of the fusion device, and the distal end of the head entity part is biased toward the rear side of the middle surface of the fusion device; And / or, the corresponding surface of the tail entity part is a fan-shaped surface, the distal end point of the corresponding surface of the tail entity part is 11.2 to 18.5 mm away from the center of the middle surface of the fusion device, and the distal end of the tail entity part is biased toward the front side of the middle surface of the fusion device.

4. The construction method according to claim 1, characterized in that: The method for constructing a fusion device body according to the control points of the upper end surface of the fusion device and the control points of the lower end surface of the fusion device specifically includes: The upper end surface of the fusion device is obtained according to the control points of the upper end surface of the fusion device; The lower end surface of the fusion device is obtained according to the control points of the lower end surface of the fusion device; The side wall of the fusion device is constructed according to the control points of the upper end surface of the fusion device and the control points of the lower end surface of the fusion device; Construct and obtain the fuser body.

5. The construction method according to claim 1, characterized in that: The cavity of the bone graft accommodating cavity occupies 75-90% of the bone graft accommodating portion, and the wall thickness of the bone graft accommodating cavity is 1-2 mm; And / or, the end surface mesh extends along the height direction of the fusion device; And / or, the total hole area of ​​the upper end surface of the bone graft receiving portion is 3.125π~7.5πmm 2 The total hole area of ​​the lower end surface of the bone graft receiving portion is 3.125π~7.5πmm 2 ; And / or, the single hole area of ​​the end surface mesh is 0.125π~1.125πmm 2 , pore diameter is 0.5~1.5mm; And / or, further comprising: constructing a side wall mesh, wherein the side wall mesh connects the side wall surface of the fusion device body and the bone graft receiving cavity, wherein the side wall mesh extends along the width direction of the fusion device, and the total hole area of ​​the side wall mesh on one side of the bone graft receiving portion is 1.25π to 2.5π mm 2 , the single hole area of ​​the side wall mesh is 0.125π~1.125πmm 2 The aperture of the side wall mesh is 0.5~1.5mm.

6. The construction method according to claim 1, characterized in that: The bone graft hole communicates with the side wall surface of the head of the fusion device body and the bone graft accommodating cavity; And / or, the diameter of the bone graft hole is 2 to 3 mm; And / or, the clamping groove is located on the side wall of the rear portion of the fusion device body.

7. A method for preparing a personalized porous intervertebral fusion cage, the method comprising: A personalized porous intervertebral fusion cage is prepared by constructing a personalized porous intervertebral fusion cage model according to the method for constructing a personalized porous intervertebral fusion cage model as described in any one of claims 1 to 6.

8. A personalized porous intervertebral fusion device, constructed by the method for constructing a personalized porous intervertebral fusion device according to any one of claims 1 to 6, or prepared by the method for preparing a personalized porous intervertebral fusion device according to claim 7.

9. A computer-readable storage medium having a computer program stored thereon, characterized in that: When the program is executed by a processor, the steps of the method for constructing a personalized porous intervertebral fusion cage model according to any one of claims 1 to 6 or the steps of the method for preparing a personalized porous intervertebral fusion cage according to claim 7 are implemented.

10. A device comprising: A processor and a memory, wherein the memory is used to store a computer program, and the processor is used to execute the computer program stored in the memory so that the device performs the steps of the method for constructing a personalized porous intervertebral fusion cage model as described in any one of claims 1 to 6, or the steps of the method for preparing a personalized porous intervertebral fusion cage as described in claim 7.

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