Liquid medicine filling system for reducing liquid medicine loss and its filling method

Abstract

The present invention discloses a liquid medicine filling system for reducing liquid medicine loss, which includes a pre-weighing and heavy work station, a filling work station, a post-weighing and heavy work station, and a liquid separation container. The bottom of the liquid separation container is inclined and provided with a plurality of liquid outlets along the length direction. Above the filling work station, a plurality of filling needles are arranged side by side. Each liquid outlet and each filling needle are respectively connected through a pipeline, and a filling pump is arranged on each pipeline. A weighing device is arranged below the filling needle at the lower position in the filling work station, and the filling needle at the lower position is the filling needle connected to the liquid outlet at the lower position. The present invention also discloses a filling method for the liquid medicine filling system for reducing liquid medicine loss, which includes the steps of: the pre-weighing and heavy work station performs pre-weighing on empty bottles; in the filling work station, the filling needles without a weighing device below fill the medicine bottles quantitatively, and the filling needles with a weighing device below supplement the liquid while weighing the medicine bottles to make the amount of medicine in each medicine bottle meet the standard. The liquid medicine filling system for reducing liquid medicine loss and its filling method can reduce manufacturing costs, improve production efficiency, and reduce the waste amount of liquid medicine.

Description

Technical Field

[0001] The present invention relates to the technical field of food and drug packaging machinery and equipment, and particularly relates to a liquid medicine filling system for reducing liquid medicine loss and a filling method thereof. Background Art

[0002] Existing liquid medicine filling systems include filling needles, filling stations, a front weighing station located in front of the filling station for weighing empty bottles, and a rear weighing station located behind the filling station for weighing the total bottles filled with liquid medicine. The filling needles are fixedly arranged above the filling station, so that a liquid supplement mechanism must be arranged at the subsequent stations of the filling station to supplement the bottles that do not reach the standard of liquid injection. As a result, the manufacturing cost of the liquid medicine filling system is increased, and the production efficiency is low. Moreover, the existing liquid supplement mechanisms have low liquid supplement efficiency and are difficult to meet the high-efficiency liquid supplement requirements. In addition, when filling liquid medicine with the existing liquid medicine filling system, a large amount of liquid medicine is wasted. At the same time, the filling volume of the liquid medicine needs to be strictly controlled. Especially in the initial stage of drug filling, there is air in the pipeline of the filling device, and it is difficult to accurately quantitatively fill during filling. After filling, if the medicine bottles do not meet the filling volume standard, they must be rejected, resulting in drug waste. Moreover, at the end stage of a batch of liquid medicine filling process, due to the insufficient total amount of liquid medicine, it is difficult to ensure that the filling volume in the medicine bottles is qualified when filling multiple medicine bottles. The medicine bottles with unqualified liquid medicine filling volume must also be rejected, resulting in drug waste again.

[0003] In the evacuation and tail liquid filling stages of the filling system during the production preparation stage, manual intervention is generally used for processing, with low efficiency, high risk of pollution, and a large amount of liquid medicine residue. According to different filling volume specifications and the number of filling heads, the general residue amount ranges from 500 ml to 2000 ml. If the residual liquid medicine can be well utilized, according to the filling volume of 2 ml medicine bottles, about 500 - 1000 qualified products can be produced more in one batch. Calculated at a market value of 100 yuan per piece, about 500,000 - 1,000,000 yuan worth of products can be produced more in one batch. Calculated by 100 batches per year, about 50,000,000 - 100,000,000 yuan worth of products can be produced more. For high-value-added biological drugs and innovative drugs, the economic benefits generated are huge. Summary of the Invention

[0004] The technical problem to be solved by the present invention is to overcome the deficiencies of the prior art and provide a liquid medicine filling system for reducing liquid medicine loss and a filling method thereof, which can reduce manufacturing costs, improve production efficiency, and reduce the amount of wasted liquid medicine.

[0005] To solve the above technical problems, the present invention adopts the following technical solutions:

[0006] A liquid medicine filling system for reducing liquid medicine loss, comprising a pre-weighing work station, a filling work station, a post-weighing work station and a liquid separation container. The bottom of the liquid separation container is inclined and provided with a plurality of liquid outlets along the length direction. Above the filling work station, a plurality of filling needles arranged side by side are provided. Each of the liquid outlets and each of the filling needles are respectively connected through pipelines, and a filling pump is provided on each of the pipelines. A weighing device is provided below the filling needle at the lower position in the filling work station, and the filling needle at the lower position is the filling needle connected to the liquid outlet at the lower position.

[0007] As a further improvement of the above technical solution:

[0008] Each of the filling needles is arranged along the conveying direction of the medicine bottles.

[0009] Among adjacent filling needles, the height of the liquid outlet connected to the front filling needle is lower than that of the liquid outlet connected to the rear filling needle.

[0010] The liquid medicine filling system for reducing liquid medicine loss further comprises a medicine supply device, a liquid inlet valve and a buffer tank. The medicine supply device and the buffer tank are connected through a liquid inlet pipeline, a liquid inlet valve is provided on the liquid inlet pipeline, and the buffer tank and the liquid separation container are connected through a connecting pipeline.

[0011] The top of the liquid separation container is provided with a liquid inlet, and the buffer tank and the liquid inlet of the liquid separation container are connected through a connecting pipeline.

[0012] The inclination angle of the liquid separation container is a, and 0° < a ≤ 10°.

[0013] A filling method for the liquid medicine filling system for reducing liquid medicine loss as described above, comprising the following steps:

[0014] The pre-weighing work station performs pre-weighing on empty bottles.

[0015] At the filling work station, the filling needles without a weighing device below perform quantitative filling on the medicine bottles, and the filling needles with a weighing device below perform liquid supplement while weighing on the medicine bottles to make the amount of liquid medicine in each medicine bottle meet the standard.

[0016] As a further improvement of the above technical solution:

[0017] The filling method for the liquid medicine filling system for reducing liquid medicine loss further comprises: at the filling work station, each filling needle performs quantitative filling on the medicine bottles.

[0018] Compared with the prior art, the advantages of the present invention are as follows:

[0019] The present invention provides a liquid medicine filling system for reducing liquid medicine loss, comprising a front weighing station, a filling station, a rear weighing station and a liquid separation container. The bottom of the liquid separation container is tilted and provided with a plurality of liquid outlets along the length direction. A plurality of filling needles arranged side by side are provided above the filling station. Each liquid outlet is connected to each filling needle through a pipeline. Each pipeline is provided with a filling pump. A weighing device is provided below the filling needle located at a lower position of the filling station. The filling needle at a lower position is a filling needle connected to a lower liquid outlet. Since a weighing device is provided below the filling needle located at a lower position of the filling station, Figure 1 and Figure 3 As shown, during the emptying of filling before normal filling production and the tail liquid filling after normal filling production, the filling needles without weighing devices above and below the filling station can be used for quantitative filling, and the filling needles above the weighing device can be used for liquid replenishment, so there is no need to add a liquid replenishment mechanism to the post-weighing station, which reduces the manufacturing cost. At the same time, the needle above the weighing device is connected to the low-position liquid outlet, which can reduce the residual amount of liquid medicine in the liquid separation container and reduce the waste of liquid medicine. And, as Figure 2 As shown, during normal quantitative filling production, this can be achieved through the filling needles above the filling station, avoiding the long-distance movement of the medicine bottle back and forth between the filling station and the post-weighing station, thereby improving production efficiency.

[0020] The filling method of the liquid medicine filling system for reducing liquid medicine loss of the present invention comprises the following steps: the front weighing station performs front weighing on the empty bottles; at the filling station, the filling needle without a weighing device below performs quantitative filling on the medicine bottles, and the filling needle with a weighing device below weighs and replenishes the medicine bottles, so that the amount of medicine in each medicine bottle meets the standard. In this filling method, the filling needle without a weighing device below performs quantitative filling on the medicine bottles, and the filling needle with a weighing device below weighs and replenishes the medicine bottles, so that the amount of medicine in each medicine bottle meets the standard, thereby improving production efficiency and reducing the amount of liquid medicine waste. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 It is a schematic structural diagram of the liquid medicine filling system of the present invention in the preparation stage.

[0022] Figure 2 It is a schematic structural diagram of the liquid medicine filling system of the present invention during normal filling production.

[0023] Figure 3 It is a comparison diagram of the liquid medicine filling system of the present invention during tail liquid filling.

[0024] Figure 4 It is a schematic structural diagram of a liquid separation container of a liquid medicine filling system of the present invention.

[0025] The symbols in the figure represent:

[0026] 1. Front rework station; 2. Filling station; 21. Weighing device; 3. Rear rework station; 4. Liquid separation container; 41. Low-level liquid outlet; 42. Liquid inlet; 5. Filling needle; 6. Pipeline; 61. Filling pump; 7. Medicine supply device; 8. Liquid inlet valve; 9. Buffer tank. Detailed implementation mode

[0027] The present invention will be further described in detail below in conjunction with the specification drawings and specific embodiments.

[0028] Figures 1 to 4 An embodiment of the liquid medicine filling system for reducing the loss of liquid medicine according to the present invention is shown. The liquid medicine filling system for reducing the loss of liquid medicine includes a front rework station 1, a filling station 2, a rear rework station 3, and a liquid separation container 4. The bottom of the liquid separation container 4 is inclined and provided with a plurality of liquid outlets along the length direction. Above the filling station 2, a plurality of filling needles 5 are arranged side by side. Each liquid outlet is connected to each filling needle 5 through a pipeline 6, and a filling pump 61 is provided on each pipeline 6. A weighing device 21 is provided below the filling needle 5 at the low level in the filling station 2. The filling needle 5 at the low level is the filling needle 5 connected to the low-level liquid outlet 41. Since the weighing device 21 is provided below the filling needle 5 at the low level in the filling station 2, therefore, as Figure 1 and Figure 3 shown, during the filling emptying before normal filling production and the tail liquid filling after normal filling production, the filling needles 5 without the weighing device 21 above and below the filling station 2 can be used for quantitative filling, and the filling needles 5 above the weighing device 21 can be used for liquid supplement. Thus, it is not necessary to add a liquid supplement mechanism at the rear rework station 3, reducing the manufacturing cost. At the same time, the needle 5 above the weighing device 21 is connected to the low-level liquid outlet 41, which can reduce the residual amount of liquid medicine in the liquid separation container 4 and reduce the waste amount of liquid medicine. And, as Figure 2 shown, during normal quantitative filling production, it can be achieved through each filling needle 5 above the filling station 2, avoiding the long-distance movement of the medicine bottle back and forth between the filling station 2 and the rear rework station 3, and improving the production efficiency.

[0029] In this embodiment, each filling needle 5 is arranged along the conveying direction F of the medicine bottle. Among the adjacent filling needles 5, the height of the liquid outlet connected to the front filling needle 5 is lower than that of the liquid outlet connected to the rear filling needle 5. That is, during the tail liquid filling, the liquid medicine in the liquid separation container 4 can be filled from high to low, and finally filled or supplemented by the filling needle 5 at the lowest level. In this way, at most only the last bottle of medicine bottle is unqualified, thereby minimizing the waste amount of liquid medicine to the greatest extent.

[0030] In this embodiment, the liquid medicine filling system for reducing liquid medicine loss further includes a medicine supply device 7, a liquid inlet valve 8, and a buffer tank 9. The medicine supply device 7 and the buffer tank 9 are connected through a liquid inlet pipeline, and the liquid inlet valve 8 is provided on the liquid inlet pipeline. The buffer tank 9 is connected to the liquid separation container 4 through a connecting pipeline. The top of the liquid separation container 4 is provided with a liquid inlet 42, and the buffer tank 9 is connected to the liquid inlet 42 of the liquid separation container 4 through a connecting pipeline. The inclination angle of the liquid separation container 4 is a. When 0° < a ≤ 10°, the amount of residual liquid medicine in the liquid separation container 4 is less.

[0031] A filling method for a liquid medicine filling system for reducing liquid medicine loss includes the following steps:

[0032] The pre-weighing work station 1 pre-weighs the empty bottles.

[0033] At the filling work station 2, the filling needle 5 without the weighing device 21 below quantitatively fills the medicine bottles, and the filling needle 5 with the weighing device 21 below replenishes the liquid while weighing the medicine bottles to make the amount of medicine in each medicine bottle reach the standard.

[0034] In this filling method, the filling needle 5 without the weighing device 21 below quantitatively fills the medicine bottles, and the filling needle 5 with the weighing device 21 below replenishes the liquid while weighing the medicine bottles to make the amount of medicine in each medicine bottle reach the standard, thereby improving the production efficiency and reducing the waste amount of liquid medicine.

[0035] In this embodiment, the filling method of the liquid medicine filling system for reducing liquid medicine loss further includes: at the filling work station 2, each filling needle 5 quantitatively fills the medicine bottles.

[0036] The specific steps are as follows:

[0037] S1: As Figure 1 shown, in the preparation stage: after the pre-weighing work station 1 pre-weighs the medicine bottles, the medicine bottles are then transported to the filling work station 2; align each medicine bottle at the filling work station 2 with each filling needle 5 respectively, open each filling pump 61, and perform quantitative filling and emptying; move the medicine bottles at the filling work station 2 forward one position at a time, perform single-bottle quantitative filling on the weighing device 21, and replenish the liquid while weighing until the amount of medicine in the medicine bottle reaches the standard;

[0038] S2: As Figure 2 shown, in the normal quantitative filling production: at the filling work station 2, perform normal quantitative filling production, filling multiple bottles at a time. During normal quantitative filling production, the filling needle 5 above the weighing device 21 is the same as other filling needles 5 above the filling work station 2 and is used for quantitative filling;

[0039] S3: As Figure 3 shown, in the tail liquid filling: the filling needle 5 above the weighing device 21 serves as the liquid replenishing filling needle 5, and other filling needles 5 quantitatively fill the medicine bottles below. The non-compliant medicine bottles are replenished through the liquid replenishing filling needle 5 until the liquid medicine in the liquid separation container 4 is emptied.

[0040] In the early filling preparation stage, the air in the pipeline is drained. At this time, due to the influence of the air in the pipeline, the filling volume of the medicine bottles does not meet the standard. By weighing while replenishing the liquid, the filling volume in the medicine bottles is made qualified, and no medicine waste will be caused. When the amount of medicine in the liquid separation container 4 is insufficient, the high-position filling needle 5 first fills quantitatively, and then the low-position filling needle 5 fills one by one to effectively utilize the tail liquid (remaining liquid medicine), ensuring that at most one bottle of liquid medicine has an unqualified filling volume.

[0041] The filling method of this liquid medicine filling system is as follows:

[0042] First step, filling and emptying (taking the filling needles 5 on the filling station 2 as an example, there are a total of 8 filling needles 5, and the frontmost one is located above the weighing device 21. The filling needles 5 are numbered A1 - A8 from front to back, the scales on the weighing station 2 are numbered B1 - B8 from front to back, and 8 medicine bottles are in a group, numbered C1 - C8 from front to back)

[0043] a) The buffer tank 9 feeds liquid intermittently to achieve bubble-free filling in the liquid separation container 4;

[0044] b) The number of bottles moved each time is 1, and the bottles are fed continuously;

[0045] c) When the medicine bottles C2 - C8 are respectively aligned with the filling needles A2 - A8, the bottle feeding is paused;

[0046] d) According to the parameters of the pipeline length and pipe diameter from the liquid separation container 4 to each filling needle 5, the filling pump 61 continuously pumps and drains the medicine to fill the corresponding pipelines, and the number of drainage times is controlled to ensure that the filling volume is within the target filling volume. For those with insufficient filling volume, the filling and weighing are supplemented by the filling needle A1 later;

[0047] e) After obtaining the tare weight of the medicine bottles C2 - C8, fill them once, and continue to move the bottles one by one;

[0048] f) The deviation values of the medicine bottles C2 - C8 are obtained one by one on the weighing device 21, and the liquid is replenished one by one;

[0049] g) After completing a group of medicine bottles, continue to weigh the tare weight of the next medicine bottles C2 - C8, fill them, and move the bottles one by one;

[0050] h) Cache the net weight value of each single filling of each medicine bottle for judging whether to perform filling calibration;

[0051] i) Judge whether the filling volume of each bottle is qualified. If it is qualified, continue to fill the next group of bottles; if it is unqualified, jump to step e, and the target filling volume at this time is the deviation value obtained in the previous round of this bottle;

[0052] j) Continuously judge the net weight values of two groups of single filling, measure the comparison deviation value, and if it meets within a certain range (for example: within 1% of the internal deviation), calculate the average value for calibration;

[0053] k) Continue filling until 5 single fills of each filling needle are qualified.

[0054] Second step, enter normal filling

[0055] Third step, tail liquid filling

[0056] a) When detecting the low liquid level of the liquid medicine in buffer tank 9 through the weighing sensor of buffer tank 9, enter the tail liquid filling mode;

[0057] b) By detecting the remaining weight of the liquid medicine in buffer tank 9 and the volumes of the liquid separation container 4 and pipeline 6 input, combined with the current filling volume, through calculation, maintain normal filling for a certain number of groups, and roughly fill 50% of the entire remaining liquid medicine (can be set according to the filling volume);

[0058] c) The number of single bottle runs is 1, and the bottles are continuously fed;

[0059] d) When the medicine bottles numbered C2 - C8 are aligned with the filling needles numbered A2 - A8 respectively, pause feeding the bottles;

[0060] e) According to the parameters of the pipeline length and pipe diameter from the liquid separation container 4 to each filling needle 5, continuously pump and empty the medicine to fill the corresponding pipeline through filling pump 61, control the number of emptying times to ensure that the filling volume is within the target filling volume. For those with insufficient filling volume, supplement while weighing through filling needle A1 later;

[0061] f) After obtaining the tare weight of the medicine bottles numbered C2 - C8, fill once, and continue to run the bottles one by one;

[0062] g) After completing a group of bottles, continue to weigh the tare weight of the next medicine bottles numbered C2 - C8, fill, and run the bottles one by one;

[0063] h) If the filling volume in a certain filling pump 61 connected to filling needles A2 - A8 is less than 20%, stop the filling corresponding to that filling pump 61 and directly reject it;

[0064] i) Finally, only feed medicine bottle C2. When the filling volume still fails to reach the target filling volume after the corresponding filling pump 61 has run for more than 30s, the entire process ends and production stops.

[0065] Although the present invention has been disclosed above in preferred embodiments, it is not intended to limit the present invention. Any person skilled in the art can make many possible changes and modifications to the technical solution of the present invention by using the technical content disclosed above without departing from the scope of the technical solution of the present invention, or modify it into an equivalent embodiment with equivalent changes. Therefore, any simple modification, equivalent change and modification made to the above embodiments based on the technical essence of the present invention without departing from the content of the technical solution of the present invention shall fall within the scope of protection of the technical solution of the present invention.

Claims

1. A liquid medicine filling system for reducing liquid medicine loss, characterized in that: It includes a pre-weighing and rework station (1), a filling station (2), a post-weighing and rework station (3), and a liquid separation container (4). The bottom of the liquid separation container (4) is inclined and provided with a plurality of liquid outlets along the length direction. Above the filling station (2), a plurality of filling needles (5) are arranged side by side. Each of the liquid outlets is connected to each filling needle (5) through a pipeline (6), and a filling pump (61) is provided on each pipeline (6). Below the filling needle (5) at the lower position in the filling station (2), there is a weighing device (21) for weighing during liquid replenishment. The filling needle (5) at the lower position is the filling needle (5) connected to the lower liquid outlet (41); Preparation stage: After the pre-weighing and rework station (1) pre-weighs the medicine bottles, the medicine bottles are then transported to the filling station (2); Align each medicine bottle on the filling station (2) with each filling needle (5) respectively, open each filling pump (61), and perform quantitative filling and emptying; Move the medicine bottles on the filling station (2) forward one position at a time, perform single-bottle quantitative filling on the weighing device (21), and replenish liquid while weighing until the amount of medicine in the medicine bottles meets the standard.

2. The liquid medicine filling system for reducing liquid medicine loss according to claim 1, wherein: Each of the filling needles (5) is arranged along the conveying direction of the medicine bottles.

3. The liquid medicine filling system for reducing liquid medicine loss according to claim 2, characterized in that: Among adjacent filling needles (5), the height of the liquid outlet connected to the front filling needle (5) is lower than that of the liquid outlet connected to the rear filling needle (5).

4. The liquid medicine filling system for reducing liquid medicine loss according to any one of claims 1 to 3, characterized in that: The liquid filling system for reducing liquid medicine loss further includes a medicine supply device (7), a liquid inlet valve (8), and a buffer tank (9). The medicine supply device (7) and the buffer tank (9) are connected through a liquid inlet pipeline, and a liquid inlet valve (8) is provided on the liquid inlet pipeline. The buffer tank (9) and the liquid separation container (4) are connected through a connecting pipeline.

5. The liquid medicine filling system for reducing liquid medicine loss according to claim 4, characterized in that: The top of the liquid separation container (4) is provided with a liquid inlet (42), and the buffer tank (9) and the liquid inlet (42) of the liquid separation container (4) are connected through a connecting pipeline.

6. The liquid medicine filling system for reducing liquid medicine loss according to any one of claims 1 to 3, characterized in that: The inclination angle of the liquid separation container (4) is a, where 0° < a ≤ 10°.

7. A filling method for a liquid medicine filling system for reducing liquid medicine loss according to any one of claims 1 to 6, characterized in that: It includes the following steps: The pre-weighing and rework station (1) pre-weighs the empty bottles. At the filling station (2), the filling needles (5) without the weighing device (21) below perform quantitative filling on the medicine bottles, and the filling needles (5) with the weighing device (21) below replenish liquid while weighing the medicine bottles to make the amount of medicine in each medicine bottle meet the standard.

8. The filling method of the liquid medicine filling system for reducing liquid medicine loss according to claim 7, characterized in that: The filling method of the liquid filling system for reducing liquid medicine loss further includes: At the filling station (2), each filling needle (5) performs quantitative filling on the medicine bottles.

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