Mass spectrometer ion source injection device

Abstract

The present invention relates to the technical field of electrospray extraction, and in particular, to a mass spectrometer ion source injection device; the mass spectrometer ion source injection device comprises an adsorption component and an ionization component, the adsorption component is used to adsorb VOC gaseous molecules in a sample; the ionization component comprises an ionization shell, a capillary and an aerodynamic lens, the aerodynamic lens is arranged in the ionization shell, and an ionization chamber cavity is arranged in the ionization shell; the capillary is arranged in the ionization shell, and the capillary extends into the ionization chamber cavity, and is used to provide electrospray, so that a particle beam in the ionization chamber cavity contacts with the electrospray to ionize to form sample ions; the ionization shell is also provided with an injection port connected to the outlet of the adsorption component, and a sample outlet connected to the ionization chamber cavity, and the sample outlet is used to allow the sample ions formed in the ionization chamber cavity to enter a mass spectrometer. The mass spectrometer ion source injection device of the present invention can improve injection efficiency and ionization efficiency.

Description

Technical Field

[0001] The invention relates to the technical field of electrospray extraction, and in particular to a mass spectrometry ion source sampling device. Background Art

[0002] Extractive electrospray ionization (EESI) is a new type of mass spectrometry (MS) ionization technology derived from electrospray ionization (ESI). Its ionization process can be summarized as follows: a high-purity solution without a sample forms charged micro-droplets through ESI, which contact and collide with sample aerosol particles, and the components to be analyzed are extracted into the charged micro-droplets to complete ionization. Compared with traditional mass spectrometry ionization technology, the EESI ion source has the following advantages: 1) Primary ions are generated through ESI, which is simple, safe, and easy to operate; 2) Samples can be atomized by a nebulizer to form aerosols for extraction ionization, without the need for cumbersome sample reagent preparation; 3) Almost all types of chemical substances except alkanes can be ionized. EESI-MS can detect the chemical composition of aerosols in real time and is currently widely used to study the composition of exhaled metabolites, the real-time evolution of atmospheric aerosol components, the flavor changes during food processing, the analysis of explosive components, and the rapid detection of urine, serum, and polluted water (refs). EESI-MS devices have broad application prospects in the fields of health care, environmental monitoring, food safety, drug development, criminal investigation, and national security.

[0003] However, the EESI source injection structure still has the problems of low injection efficiency and low ionization efficiency. Summary of the invention

[0004] The object of the present invention is to provide a mass spectrometry ion source sampling device, which can improve the sampling efficiency and ionization efficiency.

[0005] The embodiment of the present invention is achieved as follows:

[0006] In a first aspect, the present invention provides a mass spectrometry ion source injection device, comprising:

[0007] An adsorption component, the adsorption component is used to adsorb VOC gaseous molecules in the sample, and the adsorption component is provided with an outlet;

[0008] The ionization assembly comprises an ionization shell, a capillary and an aerodynamic lens. The aerodynamic lens is arranged in the ionization shell. An ionization chamber cavity is arranged in the ionization shell. Along the direction of movement of the sample in the ionization shell, the ionization chamber cavity is located downstream of the aerodynamic lens. The capillary is arranged in the ionization shell and extends into the ionization chamber cavity, and is used to provide electrospray so that the particle beam in the ionization chamber cavity contacts with the electrospray to ionize and form sample ions. The ionization shell is also provided with an inlet connected to the outlet and a sample outlet connected to the ionization chamber cavity, and the sample outlet is used to allow the sample ions formed in the ionization chamber cavity to enter the mass spectrometer.

[0009] In an optional embodiment, the ionization assembly includes at least two aerodynamic lenses, and along the direction in which the sample moves in the ionization housing, the at least two aerodynamic lenses are arranged in sequence and spaced apart.

[0010] In an optional embodiment, at least two aerodynamic lenses are coaxially distributed.

[0011] In an optional embodiment, the adsorption component includes an adsorption shell and an adsorption material disposed in the adsorption shell, the adsorption shell is provided with an inlet and an outlet, and the adsorption material is used to adsorb VOC gaseous molecules in the sample entering the adsorption shell from the inlet.

[0012] In an alternative embodiment, the adsorbent material comprises activated carbon.

[0013] In an optional embodiment, the ionization assembly further includes a fixed support and a heat sink, wherein the fixed support is connected to the ionization shell and is disposed adjacent to the sample outlet, and the heat sink is connected to a side of the fixed support facing away from the sample inlet.

[0014] In an optional embodiment, the ionization assembly further includes a heat insulation plate, which is connected to a side of the heat dissipation plate facing away from the fixed support.

[0015] In an optional embodiment, the mass spectrometry ion source sample injection device further includes an electrode focusing module, and the electrode focusing module is disposed in the ionization chamber cavity and adjacent to the sample outlet.

[0016] In an optional embodiment, the length extension direction of the capillary tube is arranged at an angle to the moving direction of the sample in the ionization housing.

[0017] In an optional embodiment, the distance between the atomization port of the capillary tube and the extension line of the axis of the aerodynamic lens is 5-15 mm.

[0018] The beneficial effects of the mass spectrometry ion source injection device of the embodiment of the present invention include: the mass spectrometry ion source injection device provided by the embodiment of the present invention includes an adsorption component and an ionization component, the adsorption component is used to adsorb VOC gaseous molecules in the sample, and the adsorption component is provided with an outlet; the ionization component includes an ionization shell, a capillary and an aerodynamic lens, the aerodynamic lens is arranged in the ionization shell, and an ionization chamber cavity is arranged in the ionization shell, along the direction of movement of the sample in the ionization shell, the ionization chamber cavity is located downstream of the aerodynamic lens; the capillary is arranged in the ionization shell, and the capillary extends into the ionization chamber cavity, and is used to provide electrospray, so that the particle beam in the ionization chamber cavity contacts with the electrospray to ionize to form sample ions; the ionization shell is also provided with an inlet connected to the outlet, and a sample outlet connected to the ionization chamber cavity, and the sample outlet is used to allow the sample ions formed in the ionization chamber cavity to enter the mass spectrometer. In this way, when injecting samples, the adsorption component can be used to remove the VOC gaseous molecules in the sample first, thereby improving the problem of the sample entering the ionization component being disturbed by the VOC gaseous molecules. The aerodynamic lens set in the ionization component can use the inertia difference between the particles and gas molecules to focus and accelerate the particles into a beam, thereby reducing the transmission loss of particles in the cavity caused by diffusion deposition, gravity sedimentation, and inertial wall collision, thereby improving the injection efficiency; and after the transmission loss is reduced, a large number of particles enter the ionization chamber cavity and contact with the electrospray to form sample ions, which can also improve the ionization efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required for use in the embodiments are briefly introduced below. It should be understood that the following drawings only show certain embodiments of the present invention and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other related drawings can be obtained based on these drawings without creative work.

[0020] Figure 1 Schematic diagram of the structure of the mass spectrometry ion source injection device in an embodiment of the present invention;

[0021] Figure 2 It is a schematic diagram of the structure of a mass spectrometry ion source injection device in other embodiments of the present invention.

[0022] Icon: 010-mass spectrometer ion source injection device; 100-adsorption assembly; 110-adsorption shell; 111-inlet; 112-outlet; 120-adsorption material; 200-ionization assembly; 210-ionization shell; 211-inlet; 212-outlet; 213-fixed support; 214-heat sink; 215-insulation plate; 220-capillary; 221-nebulizer port; 230-aerodynamic lens; 240-ionization chamber cavity; 250-mass spectrometer injection port. DETAILED DESCRIPTION

[0023] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Generally, the components of the embodiments of the present invention described and shown in the drawings here can be arranged and designed in various different configurations.

[0024] Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the invention claimed for protection, but merely represents selected embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0025] It should be noted that similar reference numerals and letters denote similar items in the following drawings, and therefore, once an item is defined in one drawing, further definition and explanation thereof is not required in subsequent drawings.

[0026] In the description of the present invention, it should be noted that the terms "inside", "outside", etc. indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, or the orientation or positional relationship in which the product of the invention is usually placed when in use, which is only for the convenience of describing the present invention and simplifying the description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the present invention. In addition, the terms "first", "second", etc. are only used to distinguish the description, and cannot be understood as indicating or implying relative importance.

[0027] In the description of the present invention, it is also necessary to explain that, unless otherwise clearly specified and limited, the terms "disposed" and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be an indirect connection through an intermediate medium, or it can be the internal communication of two elements. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0028] The EESI source injection structure provided by the related technology usually has the phenomenon of low particle injection efficiency and low ionization efficiency. This is mainly because there is a large inertia difference between aerosol particles and gaseous molecules. Aerosol particles are often prone to wall collision losses during movement. When they come into contact with charged micro-droplets, only a small amount of particles remain, resulting in low ionization efficiency.

[0029] Please refer to Figure 1The present embodiment provides a mass spectrometry ion source sampling device 010, which includes an adsorption component 100 and an ionization component 200; the adsorption component 100 is used to adsorb VOC gaseous molecules in the sample, and the adsorption component 100 is provided with an outlet 112; the ionization component 200 includes an ionization shell 210, a capillary 220 and an aerodynamic lens 230, the aerodynamic lens 230 is arranged in the ionization shell 210, and an ionization chamber cavity 240 is arranged in the ionization shell 210, and the aerodynamic lens 230 is arranged in the ionization shell 210. The ionization chamber cavity 240 is located downstream of the aerodynamic lens 230; the capillary 220 is arranged in the ionization housing 210, and the capillary 220 extends into the ionization chamber cavity 240, and is used to provide electrospray, so that the particle beam in the ionization chamber cavity 240 contacts with the electrospray to form sample ions; the ionization housing 210 is also provided with an inlet 211 connected to the outlet 112, and a sample outlet 212 connected to the ionization chamber cavity 240, and the sample outlet 212 is used to allow the sample ions formed in the ionization chamber cavity 240 to enter the mass spectrometer.

[0030] The above-mentioned VOC gaseous molecules refer to volatile organic gaseous molecules.

[0031] When injecting samples, the mass spectrometry ion source injection device 010 of this embodiment first uses the adsorption component 100 to remove the VOC gaseous molecules in the sample, thereby improving the problem of the sample entering the ionization component 200 being disturbed by the VOC gaseous molecules. The aerodynamic lens 230 provided in the ionization component 200 can use the inertia difference between the particles and the gas molecules to focus and accelerate the particles into a beam, thereby reducing the transmission loss of the particles in the cavity caused by diffusion deposition, gravity sedimentation, and inertial wall collision, thereby improving the injection efficiency; and after the transmission loss is reduced, a large number of particles enter the ionization chamber cavity 240 and contact with the electrospray to form sample ions, which can also improve the ionization efficiency.

[0032] It should be noted that EESI can ionize organic components in aerosol particles. However, the EESI source injection system provided by the related art does not have the function of distinguishing between gas and aerosol particles. In actual injection, gas and aerosol particles will be introduced at the same time, and the organic components in the aerosol particles can be ionized by the EESI source and detected in the mass spectrum, which will make it impossible to confirm whether the detected components exist in the gas phase or the particle phase, and it is difficult to apply to fields such as atmospheric chemistry research. The mass spectrometry ion source injection device 010 of this embodiment can use the adsorption component 100 to separate the gas in the particles, and can then be used in atmospheric chemistry research to understand the formation mechanism of particles, and can also be used in breath test research to accurately reveal the source of drugs.

[0033] In this embodiment, please refer to Figure 1The sample outlet 212 of the ionization housing 210 is connected to the mass spectrometer inlet 250 of the mass spectrometer, so that the sample ions formed in the ionization chamber cavity 240 are drawn into the mass spectrometer through the mass spectrometer inlet 250 for detection and analysis.

[0034] Please refer to Figure 1 The adsorption assembly 100 of this embodiment includes an adsorption shell 110 and an adsorption material 120 disposed in the adsorption shell 110. The adsorption shell 110 is provided with an inlet 111 and an outlet 112. The adsorption material 120 is used to adsorb VOC gas molecules in the sample entering the adsorption shell 110 from the inlet 111. With such a configuration, when using the mass spectrometry ion source injection device 010, before ionization, the sample can be first introduced into the adsorption shell 110 from the inlet 111, and the VOC gas molecules in the sample can be removed by using the adsorption material 120 in the adsorption shell 110, and then the sample can be introduced into the ionization assembly 200 from the outlet 112, so as to effectively remove the interference of VOC gas molecules and improve the accuracy and reliability of detection.

[0035] Furthermore, the adsorption material 120 may be activated carbon.

[0036] The number of aerodynamic lenses 230 (also called focusing nozzles) provided in the ionization assembly 200 can be selected as needed, and the number of aerodynamic lenses 230 of the ionization assembly 200 can be one, two, three, four, etc., which is not specifically limited here. When the ionization assembly 200 includes at least two aerodynamic lenses 230, along the direction in which the sample moves in the ionization housing 210, the at least two aerodynamic lenses 230 are sequentially spaced and coaxially distributed.

[0037] Please refer to Figure 1 The mass spectrometry ion source sample injection device 010 of this embodiment includes three aerodynamic lenses 230. Along the direction in which the sample moves in the ionization housing 210, the three aerodynamic lenses 230 are sequentially arranged at intervals in the ionization housing 210 and are coaxially distributed. Further, along the direction in which the sample moves in the ionization housing 210, from upstream to downstream, the apertures of the three aerodynamic lenses 230 gradually decrease. In this arrangement, the inertia difference between the particles and the gas molecules can be effectively utilized to focus and accelerate the particles into a beam, thereby reducing the transmission loss caused by the diffusion deposition, gravity sedimentation, and inertial wall collision of the particles in the cavity, thereby effectively forming a particle beam.

[0038] Furthermore, along the direction in which the sample moves in the ionization housing 210, the ionization chamber cavity 240 is located downstream of the last aerodynamic lens 230 away from the injection port 211. This arrangement ensures that the sample passing through the three aerodynamic lenses 230 forms a narrow collimated particle beam and enters the ionization chamber cavity 240, so as to improve the injection efficiency.

[0039] It should be noted that the aperture size of the aerodynamic lens 230 can be selected as needed, and its shape and specifications can also be selected as needed. It can adopt an orifice plate, a conical or trumpet-shaped nozzle, etc., which are not specifically limited here.

[0040] It should be further explained that the aerodynamic lens 230 of this embodiment has no electrode; in other embodiments, an electric focusing lens can be selected as a replacement as needed.

[0041] Please refer to Figure 1 The capillary 220 of this embodiment is inserted into the side wall of the ionization housing 210, and the atomization port 221 of the capillary 220 extends into the ionization chamber cavity 240. The electrospray provided by the capillary 220 can effectively contact and ionize with the particle beam entering the ionization chamber cavity 240, thereby forming sample ions; since the transmission loss of the sample is reduced, a large number of particles enter the ionization chamber cavity 240 and contact with the electrospray to form sample ions, which can also improve the ionization efficiency.

[0042] Furthermore, the length extension direction of the capillary 220 is set at an angle a with the moving direction of the sample in the ionization housing 210. When in use, the spray direction and the position of the atomization port 221 can be adjusted to improve the ionization effect.

[0043] Optionally, the angle a between the length extension direction of the capillary 220 and the moving direction of the sample in the ionization housing 210 may be 20-70°, which is not specifically limited herein.

[0044] It should be noted that the distance between the atomization port 221 of the capillary 220 and the extension line of the axis of the aerodynamic lens 230 can also be adjusted according to the spray direction and the position of the atomization port 221, and then the distance b between the atomization port 221 of the capillary 220 and the particle beam formed in the ionization chamber cavity 240 can be adjusted to obtain a better ionization effect.

[0045] Optionally, the distance between the atomization port 221 of the capillary 220 and the extension line of the axis of the aerodynamic lens 230 is 5-15 mm, so that the distance b between the atomization port 221 of the capillary 220 and the particle beam in the ionization chamber cavity 240 is 5-15 mm, which is not specifically limited here.

[0046] It should be noted that the number of the capillaries 220 can be selected as needed. The ionization component 200 of this embodiment includes one capillary 220 .

[0047] Please refer to Figure 2In other embodiments, the number of the capillaries 220 may be two, and the two capillaries 220 are arranged at intervals along the direction in which the sample moves in the ionization housing 210. Of course, in other embodiments, the number of the capillaries 220 may be three, four, etc., and may be freely selected according to the ionization requirements of the particle sample. It should be noted that when the number of the capillaries 220 is greater than or equal to two, the angles at which the capillaries 220 are arranged and the positions of the atomization ports 221 may be consistent or inconsistent, and are not specifically limited here.

[0048] It should be noted that the capillary 220 of this embodiment is a fused silica capillary 220, which is used to provide nanoliter electrospray. Nanoliter electrospray generally refers to an electrospray with a flow rate of 1-1000nL per minute at the nanoliter level, with a typical value of 100nL / min. The nanoliter electrospray ionization effect is better than that of traditional electrospray. Of course, in other embodiments, it can also be replaced by traditional electrospray, which is usually greater than 1mL / min, and is not specifically limited here.

[0049] It should be further explained that the use of conventional electrospray ionization (ESI) to generate primary ions requires the use of auxiliary gas to improve the desolvation efficiency and ESI efficiency. However, the auxiliary gas will disturb the interaction between the primary spray and the sample aerosol, reduce the stability of the secondary ionization process, and thus affect the reproducibility of the analysis results. Nanoliter electrospray (nanoliter ESI electrospray) does not require auxiliary gas, and will not disturb the interaction between the primary spray and the sample airflow.

[0050] Alkanes are an important class of chemical substances. For example, in the study of breath metabolome, alkanes are the final products of lipid peroxidation and can be used to monitor the degree of peroxidative damage in the human body. Alkanes are also an important class of volatile organic compounds in the atmosphere. However, the EESI source provided by the related art has low ionization efficiency for low-polarity substances and cannot ionize alkanes. In order to enhance the ionization effect of the mass spectrometry ion source injection device 010 provided in the present application on low-polarity substances, a power supply discharge needle, an ultraviolet lamp or a laser, etc. can also be coupled in the ionization chamber cavity 240.

[0051] Please refer to Figure 1 The ionization assembly 200 of this embodiment further includes a fixed support 213 and a heat sink 214. The fixed support 213 is connected to the ionization housing 210 and is arranged adjacent to the sample outlet 212. The heat sink 214 is connected to the side of the fixed support 213 that is away from the sample inlet 211. With such an arrangement, when the mass spectrometer ion source injection device 010 is used, the heat sink 214 can be located between the ionization chamber cavity 240 and the mass spectrometer injection port 250. The heat sink 214 is used to dissipate heat to reduce the heat generated by the mass spectrometer injection port 250 connected to the sample outlet 212, and to make the temperature in the ionization chamber cavity 240 suitable to effectively ionize volatile components.

[0052] The heat sink 214 can be made of various types of materials with good heat dissipation performance as needed, and is not specifically limited here. The heat sink 214 in this embodiment is a heat dissipation aluminum plate.

[0053] Furthermore, the ionization assembly 200 of the present embodiment further includes a heat insulating plate 215, which is connected to the side of the heat sink 214 away from the fixed support 213. With such a configuration, when the mass spectrometer ion source injection device 010 is used, the heat insulating plate 215 can be located between the ionization chamber cavity 240 and the mass spectrometer injection port 250, and the heat insulating plate 215 can be used to effectively block the heat generated by the mass spectrometer injection port 250, and further make the temperature in the ionization chamber cavity 240 suitable, so as to effectively ionize the volatile components.

[0054] The heat insulation board 215 can be made of various types of materials with good heat insulation performance as needed, and no specific limitation is made here; the heat insulation board 215 of this embodiment is a polytetrafluoroethylene heat insulation board 215.

[0055] It should be noted that when using the mass spectrometer ion source injection device 010, the side of the heat shield 215 facing away from the heat sink 214 can be connected to the mass spectrometer. On the one hand, the heat shield 215 can be used to effectively isolate the heat generated by the mass spectrometer injection port 250, and on the other hand, it can ensure that the mass spectrometer injection port 211 is reliably connected to the sample outlet 212 of the ionization assembly 200. Furthermore, the connection method between the heat shield 215 and the mass spectrometer can be abutment, clamping, etc., which is not specifically limited here.

[0056] It should be noted that the use of capillary 220 for sampling is a commonly used sampling method for atmospheric pressure ionization mass spectrometry (API-MS). The pipeline needs to be heated to prevent water vapor condensation from clogging the capillary 220. The temperature is usually greater than 100°C. The provision of a heat insulation plate 215 and a heat sink 214 between the ionization chamber cavity 240 and the mass spectrometer injection port 250 can effectively prevent the chemical components of the sample particles from volatilizing before ionization, thereby ensuring effective ionization.

[0057] Optionally, the mass spectrometer ion source injection device 010 further includes an electrode focusing module (not shown), which is disposed in the ionization chamber cavity 240 and adjacent to the sample outlet 212. In this arrangement, the electrode focusing module can be located between the mass spectrometer injection port 250 and the ionization chamber cavity 240, so that the electrode focusing module can be used to further focus the sample ions, so as to ensure that the sample ions reliably enter the mass spectrometer from the mass spectrometer injection port 250, thereby reducing the loss of the sample ions at the mass spectrometer injection port 250, so as to further improve the injection efficiency of the sample ions.

[0058] The non-sealed design of the EESI source will allow indoor air to enter the ion source area, generate background interference, and reduce the sensitivity of the method. In order to improve the above problems, the mass spectrometry ion source injection device 010 can be sealed. In this embodiment, the adsorption shell 110 is connected to the ionization shell 210, and the outlet 112 of the adsorption shell 110 is connected to the injection port 211 of the ionization shell 210. The adsorption shell 110 and the ionization shell 210 are tightly connected to form a sealed state.

[0059] It should be noted that the connection method of the adsorption shell 110 and the ionization shell 210 can be selected as needed, such as welding or clamping, etc., which is not specifically limited here. When the adsorption shell 110 and the ionization shell 210 are connected by clamping or the like, a sealing member such as a sealing rubber ring can also be provided between the adsorption shell 110 and the ionization shell 210.

[0060] The working steps of the mass spectrometry ion source injection device 010 of the present embodiment include: allowing the sample to enter the interior of the adsorption shell 110 from the inlet 111 of the adsorption shell 110, and the adsorption material 120 in the adsorption shell 110 adsorbs and removes the VOC gaseous molecules in the sample to obtain an aerosol sample; the aerosol sample enters the injection port 211 of the ionization shell 210 from the outlet 112 of the adsorption shell 110, and then passes through three aerodynamic lenses 230 in sequence to be focused to form a narrow collimated particle beam, and the particle beam enters the ionization chamber cavity 240, and the particle beam is ionized by contact with the nanoliter electrospray provided by the capillary 220 to form sample ions, and the sample ions can be drawn into the mass spectrometer through the sample outlet 212 of the ionization shell 210 and the mass spectrometry injection port 250 for detection and analysis.

[0061] In summary, the mass spectrometry ion source injection device 010 provided by the present invention first uses the adsorption component 100 to remove the VOC gaseous molecules in the sample during injection, thereby improving the problem of the sample entering the ionization component 200 being interfered by the VOC gaseous molecules. The aerodynamic lens 230 provided in the ionization component 200 can utilize the inertia difference between the particles and the gas molecules to focus and accelerate the particles into a beam, thereby reducing the transmission loss of the particles in the cavity caused by diffusion deposition, gravity sedimentation, and inertial wall collision, thereby improving the injection efficiency; and after the transmission loss is reduced, a large number of particles enter the ionization chamber cavity 240 and contact with the electrospray to form sample ions, thereby improving the ionization efficiency.

[0062] The above are only preferred embodiments of the present invention and are not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A mass spectrometry ion source sampling device, characterized in that: include: An adsorption component, the adsorption component is used to adsorb VOC gaseous molecules in the sample, and the adsorption component is provided with an outlet; An ionization assembly, the ionization assembly comprising an ionization shell, a capillary and an aerodynamic lens, wherein the aerodynamic lens is arranged in the ionization shell, an ionization chamber cavity is arranged in the ionization shell, and along the direction of movement of the sample in the ionization shell, the ionization chamber cavity is located downstream of the aerodynamic lens; the capillary is arranged in the ionization shell, and the capillary extends into the ionization chamber cavity, and is used to provide electrospray, so that the particle beam in the ionization chamber cavity contacts with the electrospray to ionize to form sample ions; the ionization shell is also provided with an inlet communicated with the outlet, and a sample outlet communicated with the ionization chamber cavity, and the sample outlet is used to allow the sample ions formed in the ionization chamber cavity to enter a mass spectrometer; The ionization assembly further comprises a fixed support and a heat sink, wherein the fixed support is connected to the ionization shell and is arranged adjacent to the sample outlet, and the heat sink is connected to a side of the fixed support away from the sample inlet; The ionization assembly includes at least two aerodynamic lenses. Along the direction in which the sample moves in the ionization housing, the at least two aerodynamic lenses are arranged in sequence and spaced apart from each other.

2. The mass spectrometry ion source sampling device according to claim 1, characterized in that: At least two of the aerodynamic lenses are coaxially distributed.

3. The mass spectrometry ion source sampling device according to claim 1, characterized in that: The adsorption component comprises an adsorption shell and an adsorption material arranged in the adsorption shell. The adsorption shell is provided with an inlet and the outlet. The adsorption material is used for adsorbing VOC gaseous molecules in a sample entering the adsorption shell from the inlet.

4. The mass spectrometry ion source sampling device according to claim 3, characterized in that: The adsorbent material includes activated carbon.

5. The mass spectrometry ion source sampling device according to claim 1, characterized in that: The ionization assembly further comprises a heat insulation plate, and the heat insulation plate is connected to a side of the heat dissipation plate facing away from the fixed support.

6. The mass spectrometry ion source sampling device according to claim 1, characterized in that: The mass spectrometry ion source sampling device further comprises an electrode focusing module, and the electrode focusing module is arranged in the cavity of the ionization chamber and adjacent to the sample outlet.

7. The mass spectrometry ion source sampling device according to claim 1, characterized in that: The length extension direction of the capillary tube is arranged at an angle to the moving direction of the sample in the ionization shell.

8. The mass spectrometry ion source sampling device according to claim 1, characterized in that: The distance between the atomization port of the capillary tube and the extension line of the axis of the aerodynamic lens is 5-15 mm.

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