Test pre-processing device, medical equipment and testing method

Abstract

The present invention discloses a pre-test processing device, medical equipment and a detection method, wherein the pre-test processing device includes a tray having at least one limiting groove; a tray fixing fixture having a structure for installing and fixing the tray; a material supply mechanism having a structure for storing materials in batches and transferring the materials one by one to the tray; a test liquid storage mechanism having a group of containers; and an injection mechanism having a structure that can extend into any of the containers to absorb liquid and inject it into the groove of the material on the tray. This solution installs reagent strips by setting a tray, and stores batches of materials through a material supply mechanism and transfers the stored materials to the tray to meet the test needs. Combined with the injection mechanism, the test liquid in the container is automatically injected into the groove of the reagent strip on the tray, which can meet the needs of large-scale and multi-item testing, create equipment conditions for the automation of various tests, and help improve detection efficiency.

Description

Technical Field

[0001] The present invention relates to the field of medical equipment, in particular to a pre-test processing device, medical equipment and a detection method. Background Art

[0002] Cyclic enhanced fluorescence immunoreaction is a highly sensitive fluorescence immunoreaction that enhances the intensity of the fluorescence signal through a certain method, thereby making it possible to detect low-concentration targets.

[0003] It is a general trend to realize this reaction and corresponding detection through automated equipment. In automated detection, the reagent strip is the material required for the test, which is provided with

[0004] (1) Reading wells, where the fluorescence signal on the probe is read;

[0005] (2) Cleaning the wells to remove interfering substances, excess signal antibodies, and excess fluorescent signals in the sample on the probe;

[0006] (3) Dry reagent wells, which contain dry reagents for sample processing, signal antibodies, and fluorescent signals, which react with the probe after dissolution;

[0007] (4) A probe storage hole in which the probe is stored and locked with a protective cover.

[0008] During the test, the reagent strip needs to be pre-treated to facilitate the subsequent addition of the test solution for the supplied reaction and test.

[0009] In order to meet the requirements of large-scale multi-item testing, the first problem to be solved is that the automated equipment needs to be able to store multiple reagent strips and enable the reagent strips to be automatically transferred and supplied;

[0010] The second is to be able to automatically inject the test solution into the different holes of the reagent strip. Summary of the invention

[0011] The purpose of the present invention is to solve the above problems existing in the prior art and to provide a test pre-processing device, medical equipment and detection method.

[0012] The purpose of the present invention is achieved through the following technical solutions:

[0013] Test pre-processing device, including

[0014] The tray has at least one limiting groove;

[0015] A pallet fixing jig has a structure for installing and fixing the pallet;

[0016] A material supply mechanism, which has a structure for storing materials in batches and transferring the materials one by one onto a pallet;

[0017] a test fluid storage mechanism having a set of containers;

[0018] The injection mechanism has a structure that can extend into any of the containers to absorb liquid and inject it into the groove of the material on the tray.

[0019] Preferably, the tray has at least 5 side-by-side limiting grooves.

[0020] Preferably, the material supply mechanism includes

[0021] Material storage device with multiple layers of openable and closable drawers;

[0022] A multifunctional manipulator having an adsorption device for adsorbing the drawer and a first clamping mechanism for clamping materials in the drawer;

[0023] The moving mechanism drives the multifunctional manipulator to move.

[0024] Preferably, the multifunctional manipulator further comprises a code reader, and the code reader is tiltedly arranged with its lens facing downward and toward the material storage device.

[0025] Preferably, the injection mechanism at least includes a vertical nozzle connecting tube, a suction injection mechanism connected to the upper end of the nozzle connecting tube, the nozzle connecting tube is connected to a mechanism that drives it to move horizontally along a first horizontal direction Y and / or a second horizontal direction X and along a vertical direction Z, and the suction injection mechanism moves horizontally synchronously with the nozzle connecting tube.

[0026] Preferably, the suction injection mechanism includes a syringe connected to the suction nozzle connecting tube and a mechanism for driving a piston rod of the syringe, and the suction nozzle is perpendicular to the syringe.

[0027] Preferably, the injection mechanism also includes a feeder and an automatic nozzle supply mechanism located next to it, the feeder includes a limit plate located within the moving range of the nozzle connecting tube and perpendicular to the nozzle connecting tube, at least one perforation is formed on the limit plate, and when the nozzle connecting tube is coaxial with the perforation, its outer wall maintains a distance from the hole wall of the perforation.

[0028] Preferably, the automatic nozzle supply mechanism includes

[0029] The storage bin has a storage space for storing multiple layers of stacked objects, and its bottom is a discharge port;

[0030] A conveying jig, which is located a certain distance below the storage bin and can move between a first horizontal position and a second horizontal position. At the first horizontal position, it corresponds to the unloading port of the storage bin; at the second horizontal position, it is located outside the storage bin;

[0031] The automatic unloading mechanism can move the multi-layer stacked objects one by one to the conveying fixture at the first horizontal position.

[0032] Preferably, the pre-test processing device also includes a film opening mechanism, including a row of film opening cones arranged along the extension direction of the limiting groove, the film opening cones are vertically arranged, and the row of film opening cones are connected to a mechanism that drives them to move vertically and horizontally synchronously.

[0033] Preferably, the pre-test processing device also includes

[0034] The cover opening mechanism at least comprises a first cover opening plate, the first cover opening plate is vertical and perpendicular to the limit groove, and the first cover opening plate is connected to a mechanism for driving the lifting and translation of the first cover opening plate;

[0035] The probe transfer mechanism comprises a probe clamp and a mechanism for driving the probe clamp to rise, fall and translate. The probe transfer mechanism translates synchronously with the cover opening mechanism.

[0036] Preferably, the pre-test processing device comprises a horizontal pressure rod, the extension direction of which is perpendicular to the limiting slot and connected to a mechanism for driving its translation and lifting, and the pressure rod can be translated to just above the limiting slot.

[0037] Preferably, the pre-test processing device comprises

[0038] A pallet positioning fixture having a limiting structure for positioning the pallet;

[0039] The pallet transfer mechanism has a structure for moving the pallet between the pallet fixing fixture and the pallet positioning fixture.

[0040] Preferably, the pre-test processing device comprises

[0041] A blanking plate, which is vertically arranged and perpendicular or parallel to the limiting groove of the pallet on the pallet fixing jig;

[0042] The tray transfer mechanism comprises

[0043] The pallet clamp includes two clamping rods of equal height and extending horizontally and an opening and closing driving device for driving them to open and close, wherein the clamping rods are perpendicular or parallel to the blanking plate;

[0044] A clamping jaw flipping mechanism, connected to the pallet clamping jaw and driving it to rotate around an axis parallel to the clamping rod;

[0045] The moving mechanism drives the clamping and flipping mechanism to move in translation and lifting, and the clamping rod moves between the upper and lower positions of the blanking plate and moves from the outer side of the blanking plate to a position corresponding to the blanking plate in the vertical direction.

[0046] Preferably, the lower end surface of the blanking plate of the pre-test processing device is a set of planes with height differences.

[0047] Medical equipment, including any of the above-mentioned pre-test processing devices.

[0048] The detection method comprises at least the following steps:

[0049] S1, the pallet is fixed on the pallet fixing fixture;

[0050] S3, the material supply mechanism moves at least one material to a limiting groove of the tray for limiting;

[0051] S5, the injection mechanism sucks liquid from the designated container and injects it into the groove of the material on the tray according to the metered amount.

[0052] Preferably, S3 includes

[0053] S31, the suction device on the multifunctional manipulator suctions the drawer and opens the drawer;

[0054] S32, a barcode reader on the multifunctional robot reads the barcode on the material in the drawer to determine the type, quantity and location of the material;

[0055] S33, the first clamping mechanism on the multifunctional manipulator clamps at least one material in the drawer and moves it out of the drawer and places it in the limiting groove of the tray.

[0056] Preferably, the method further comprises S41 located between S3 and S5, wherein the protective film on the surface of the material on the pallet is punctured by a film opening mechanism.

[0057] Preferably, it further includes S42 located between S3 and S5, opening the protective cover on the material through the cover opening mechanism and taking the probe out of the material and placing it on the tray through the probe transfer mechanism.

[0058] Preferably, the method further comprises S43 located between S3 and S5, wherein the pallet is moved from the pallet fixing jig to the pallet positioning jig by a pallet transfer mechanism.

[0059] Preferably, S3 includes, before sucking different test liquids, unloading the suction nozzle on the suction tube connecting nozzle through a feeder and moving the suction nozzle connecting tube to a conveying fixture at a second horizontal position to replace the suction nozzle.

[0060] Preferably, it includes S07, after the test is completed, the pallet is flipped 180 degrees by the pallet transfer mechanism and moved under the unloading plate, and the pallet is lifted so that the unloading plate applies downward pressure to the material in the pallet until the material falls from the limiting groove. After unloading is completed, the pallet transfer mechanism flips the pallet 180 degrees again and places it on the pallet fixing fixture.

[0061] The advantages of the technical solution of the present invention are mainly reflected in:

[0062] This solution sets up a tray to install reagent strips, and stores batches of materials through a material supply mechanism and transfers the stored materials to the tray to meet testing needs. Combined with an injection mechanism, the test liquid in the container is automatically injected into the slot of the reagent strip on the tray, which can meet the testing needs of large quantities of multiple projects, creates equipment conditions for the automated implementation of various tests, and is conducive to improving detection efficiency.

[0063] The material storage device of this scheme is provided with a drawer with a blister box limit groove, so that the reagent strip can be placed in the blister box and then inserted into the blister box limit groove for storage. When the reagent strip is needed, the drawer can be opened, so that it is convenient to cooperate with the automatic material taking structure to realize the reagent strip from the drawer for use, and when inserting the blister box, the drawer is restricted by the first limit mechanism so that it will not open, thereby effectively reducing the difficulty of inserting the blister box and improving operability. The storage device is effective enough to cooperate with the multifunctional manipulator to realize the storage and reprinting needs of the reagent strip. At the same time, by integrating an electromagnetic adsorption device on the manipulator, the drawer can be opened by electromagnetic adsorption when taking the material, so that it is convenient to take the material through the first clamping mechanism thereon later. By setting a barcode scanner, the type, quantity and position of the reagent strip in the drawer can be effectively determined, providing data support for the control of the first clamping mechanism, greatly improving the integration of the equipment, and allowing multiple components to share a mobile mechanism, which can effectively simplify the structure.

[0064] The first limiting mechanism of the present invention can limit the opening of a plurality of drawers at the same time, thereby helping to simplify the limiting structure, reduce the number of power sources, and reduce equipment costs.

[0065] This solution sets a second limiting mechanism, which can limit the opening of each drawer, and can cooperate with the first limiting mechanism to achieve double assurance. At the same time, the second limiting mechanism can also cooperate with the second protrusion on the drawer to limit the drawer closing, thereby avoiding the problem of unstable unloading caused by the movement of the drawer during subsequent unloading of the reagent strip. The second limiting mechanism can share a linear drive mechanism, which can effectively simplify the drive structure and reduce equipment costs.

[0066] The first clamping mechanism of the present invention is driven by a motor, and can flexibly adjust the opening and closing size of the clamping jaws according to needs, thereby adapting to the clamping requirements of objects of different sizes, and has good application flexibility.

[0067] The multifunctional manipulator of the present invention is further integrated with an opening mechanism, which can effectively realize the automatic opening of the probe protection cover, and the opening mechanism of the present invention can open all the probe protection covers of all the reagent strips on the tray in one operation, with high opening efficiency and good stability, which is conducive to simplifying the structure and enriching the functions of the equipment. The reagent strip can be fixed by the pressure rod when opening the cover, thereby avoiding the loosening and displacement of the reagent strip caused by the opening action, which is conducive to ensuring the stability of subsequent operations. The probe clamp with flexible opening and closing size is further integrated, which can easily move the probe to the probe storage hole on the tray after opening the cover, so as to provide convenience for subsequent tests.

[0068] This solution can accurately puncture the membrane on each hole of the reagent strip at one time through a membrane opening device with multiple membrane opening cones to open the membrane, creating basic conditions for subsequent addition of test liquid, providing technical support for the realization of automation, and enriching product functions.

[0069] The solution drives the nozzle connecting tube to move through the moving mechanism, and by making the nozzle connecting tube coaxial with the axis of the syringe, the length of the entire automatic injection structure can be effectively shortened, thereby helping to reduce the overall height of the device. The design of the suction injection mechanism of the solution, especially the push-pull mechanism, is driven by a motor and combined with a solenoid valve, which can conveniently control the single injection volume and flexibly meet different test needs.

[0070] This solution is achieved by setting a perforation on the limit plate of the feeder to facilitate the nozzle connecting tube with the nozzle inserted to pass through the lower part of the perforation, and then the nozzle connecting tube is moved so that the top of the nozzle is located at the bottom of the limit plate around the perforation, and then the nozzle connecting tube is raised to separate the nozzle and the nozzle connecting tube, thereby providing basic conditions for replacing the nozzle to realize testing of different projects.

[0071] The storage bin of the present solution can store multiple storage boxes. Combined with the automatic unloading mechanism, the stacked storage boxes in the storage bin can be effectively separated one by one onto the conveying jig for conveying. Combined with the conveying jig, a storage box in the storage bin can be conveyed to the outside of the storage bin for use, thereby greatly increasing the supply of suction tips and reducing the frequency of adding storage boxes, which is conducive to meeting the requirements of large-scale testing.

[0072] The conveying fixture of this solution adopts a slide-type conveying mechanism, and the translation drive structure is located on the outside, which can facilitate assembly operations and reduce the difficulty of processing and maintenance. In addition, the conveying fixture can effectively cooperate with the nozzle connection pipe to realize automatic unloading of the material box, which is conducive to improving the efficiency of replacing the material box.

[0073] The automatic unloading mechanism of this solution adopts the combination of grooves and rollers to realize the opening and closing of the clamping arm, which can effectively ensure the opening and closing accuracy and stability.

[0074] This solution is achieved by setting up a vertical unloading plate and a reversible tray clamp. The tray clamp is used to clamp the tray and flip the tray 180° so that the reagent strip is oriented. The reagent strip can then be moved to the unloading plate by raising and lowering the tray. As the tray continues to rise, the unloading plate provides downward pressure on the reagent strip to make it withdraw from the tray, and unloading is completed under its own weight.

[0075] The unloading plate of the present invention is in a state perpendicular to the clamping rod, which can effectively unload multiple reagent strips in one unloading action, and can greatly improve the unloading efficiency.

[0076] The bottom of the blanking plate of this solution adopts a planar structure with different height differences, which can make the bottom surface of the blanking plate contact with reagent strips at different positions in batches, thereby reducing the downward pressure required for blanking, which is conducive to improving the smoothness and stability of blanking. BRIEF DESCRIPTION OF THE DRAWINGS

[0077] Figure 1 is a perspective view of a tray of the present invention;

[0078] Figure 2 is a top view of a pallet of the present invention fixed on a pallet fixing jig;

[0079] Figure 3 is a three-dimensional diagram of the present invention (the external enclosure of the whole machine is hidden in the figure);

[0080] Figure 4 is a three-dimensional diagram of the material supply mechanism of the present invention;

[0081] Figure 5 is a first perspective stereoscopic view of the material storage device of the present invention;

[0082] Figure 6 is a second perspective stereoscopic view of the material storage device of the present invention;

[0083] Figure 7 is an inner end view of the material storage device of the present invention;

[0084] Figure 8 yes Figure 6 A magnified image of area A;

[0085] Fig. 9 yes Figure 7 Enlarged view of area B;

[0086] Fig.10 is a side view of the material storage device of the present invention;

[0087] Fig.11 is a three-dimensional diagram of the multifunctional manipulator of the present invention;

[0088] Fig.12 is a front view of the multifunctional manipulator of the present invention;

[0089] Fig.13 is a bottom view of the multifunctional manipulator of the present invention;

[0090] Fig.14 yes Fig.12 Enlarged view of the middle C area;

[0091] Fig.15 It is a three-dimensional diagram of the multifunctional manipulator of the present invention being arranged on a structure driving the lifting thereof;

[0092] Fig.16 It is a first-perspective stereoscopic diagram of the multifunctional manipulator of the present invention arranged on a structure driving the lifting and translation thereof;

[0093] Fig.17 It is a second perspective stereogram of the multifunctional manipulator of the present invention arranged on a structure driving the lifting and translation thereof;

[0094] Fig.18 It is a three-dimensional diagram of the cover opening mechanism and the probe transfer mechanism of the present invention;

[0095] Fig.19 yes Fig.18 A front view of

[0096] Fig. 20 yes Fig.18 A cross-sectional view of the middle probe jaw;

[0097] Fig.21 It is a schematic diagram of the positional relationship between the film opening cone and the tray of the present invention;

[0098] Fig. 22 It is a top view of the tray, tray fixing fixture, film opening mechanism and pressure rod of the present invention;

[0099] Fig.23 is a stereoscopic view of the injection mechanism of the present invention;

[0100] Fig.24 yes Fig.23 Enlarged view of area D in the middle;

[0101] Fig.25 It is a three-dimensional diagram of the injection mechanism with a feeder of the present invention;

[0102] Fig.26 yes Fig.25 A top view of

[0103] Fig. 27 yes Fig.26 Enlarged view of the middle E area;

[0104] Fig.28It is a three-dimensional diagram of the injection mechanism with a feeder and a suction nozzle automatic supply mechanism of the present invention;

[0105] Fig.29 yes Fig.28 A three-dimensional diagram without the structure of the automatic nozzle supply mechanism and the drive conveying fixture;

[0106] Fig.30 is a first-view stereoscopic diagram of the automatic nozzle supply mechanism of the present invention;

[0107] Fig.31 It is a partial side view of the feeding side of the automatic nozzle supply mechanism of the present invention;

[0108] Fig.32 is a three-dimensional view of a storage bin with a door of the automatic nozzle supply mechanism of the present invention;

[0109] Fig.33 yes Fig.31 Enlarged view of the middle F area;

[0110] Fig.34 is a second perspective stereogram of the automatic nozzle supply mechanism of the present invention;

[0111] Fig.35 It is a side view of the automatic nozzle supply mechanism of the present invention, in which a part of the automatic material discharge mechanism is hidden;

[0112] Fig.36 It is a three-dimensional diagram of the pallet positioning fixture, the pallet transfer mechanism and the blanking plate area of ​​the present invention;

[0113] Fig.37 yes Fig.36 Enlarged view of the middle G region;

[0114] Fig.38 It is a front view of the blanking plate of the present invention;

[0115] Fig.39 is a three-dimensional diagram of the pallet positioning jig and the automatic turntable area of ​​the present invention;

[0116] Fig.40 yes Fig.39 Top view of the . DETAILED DESCRIPTION

[0117] The purpose, advantages and features of the present invention will be illustrated and explained by the non-limiting description of the following preferred embodiments. These embodiments are only typical examples of the application of the technical solution of the present invention, and any technical solution formed by equivalent replacement or equivalent transformation falls within the scope of protection claimed by the present invention.

[0118] In the description of the scheme, it should be noted that the terms "center", "up", "down", "left", "right", "front", "back", "vertical", "horizontal", "inside", "outside" and the like indicate positions or positional relationships based on the positions or positional relationships shown in the drawings, and are only for the convenience of description and simplified description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation of the present invention. In addition, the terms "first", "second", and "third" are used for descriptive purposes only, and cannot be understood as indicating or implying relative importance. Moreover, in the description of the scheme, with the operator as a reference, the direction close to the operator is the proximal end, and the direction away from the operator is the distal end.

[0119] The following is an explanation of the pre-test processing device disclosed by the present invention in conjunction with the accompanying drawings. It can be used to perform various processing required for the test on the reagent strip before the cyclic enhancement of the fluorescent immunoreaction. Of course, it can also be used for other tests. Figure 1 As shown, it includes a tray 200, and the tray 200 is used to limit the position of a reagent strip (not shown in the figure) to facilitate various operations on the reagent strip.

[0120] Specifically, as attached Figure 1 As shown, the tray 200 includes a main body 220, and at least one limiting groove 210 is formed on the main body 220. Preferably, the limiting grooves 210 are 10 and are arranged in parallel, and each of the limiting grooves 210 includes two parallel and spaced apart, vertically arranged limiting surfaces 211, a bottom surface 212 located at their lower ends is arranged between the two limiting surfaces 211, and a distal limiting rod 213 is arranged in the outer gap at one end of the two limiting surfaces 211, and a proximal limiting rod 214 perpendicular to them is connected to their other ends, the top surface of the distal limiting rod 213 is higher than the bottom surface 212, and the gap 215 between the distal limiting rod 213 and the limiting surface 212 is used for subsequently removing the reagent strip from the limiting groove 210.

[0121] As attached Figure 1 As shown, the end surface of the distal limiting rod 213 facing the proximal limiting rod 214 is an inclined surface and a retaining groove 216 is formed thereon. The retaining groove 216 is used to limit the reagent strip in the limiting groove 210. The retaining groove 216 is an arc-shaped through groove recessed in the side wall, and both ends of the arc-shaped through groove extend to the top surface and the bottom surface of the proximal limiting rod 213.

[0122] As attached Figure 1As shown, the top edge width of the arc surface of the arc-shaped through groove is smaller than the bottom edge width, and the distance from the midpoint of the top edge of the arc surface to the proximal limiting rod is smaller than the distance from the midpoint of the bottom edge to the proximal limiting rod, thereby being able to adapt to changes in the total length of the reagent strip and facilitating the control of the force required to press the reagent strip into the carrier.

[0123] As attached Figure 1 As shown, a probe receiving hole 230 matching each of the limiting grooves is formed on the main body 220. The probe receiving hole 230 is specifically arranged on the distal limiting rod 214, so that it can be used for temporary storage of the probe on the reagent strip.

[0124] As attached Figure 1 , Attachment Figure 2 As shown, the pallet 200 is fixed on the pallet fixing fixture 300 and the limiting groove 210 thereon extends along the second horizontal direction X. The pallet fixing fixture 300 is fixed on a plate 4000. Fig. 22 As shown, the pallet fixing fixture 300 includes a pallet positioning plate 310, and the positioning plate 310 is provided with through holes 311 located on both sides of the pallet 200, and each of the through holes 311 is movably provided with an L-shaped fixing plate 320, and the L-shaped fixing plate 320 can drive its fixing release driving mechanism 330 to reciprocate along the direction perpendicular to the side of the pallet 200. After the two L-shaped fixing plates 320 move toward each other, they can press on both sides of the pallet to fix the pallet 200 on the positioning plate 310, and when the L-shaped fixing plates 320 move in opposite directions, the fixation of the pallet 200 can be released. Further, the fixing release mechanism 330 can also be connected to a lifting driving device (not shown in the figure) that drives it to rise and fall.

[0125] After the tray 200 is fixed on the tray fixing fixture 300, during testing, the reagent strip needs to be placed in the limiting groove of the tray 200 for testing. Figure 3 , Attachment Figure 4 As shown, a material supply mechanism 1000 is provided on the side of the pallet fixing fixture 300 , and the material supply mechanism 1000 has a structure for storing materials in batches and transferring the materials one by one onto the pallet.

[0126] Specifically, as shown in the attached Figure 4 As shown, the material supply mechanism 1000 includes a material storage device having multiple layers of openable and closable drawers;

[0127] A multifunctional manipulator having an adsorption device for adsorbing the drawer and a first clamping mechanism for clamping materials in the drawer;

[0128] The moving mechanism drives the multifunctional manipulator to move.

[0129] Among them, as attached Figure 3 As shown, the material storage device is also arranged on the platform 4000, which is located on the left side of the pallet fixing fixture 300. Figure 5 As shown, it includes an outer frame 1, which is a rectangular frame composed of four side panels. At least one drawer 2 is arranged in the outer frame 1, and the drawer 2 can be translated to the outside of the outer frame 1. The drawer 2 is preferably a slide-type drawer, and its specific structure is a known technology and is not described here. At least one blister box limiting groove 21 is formed on the drawer 2, and the blister box limiting groove 21 is used to limit the blister box, and the blister box is used to store reagent strips. The blister box limiting groove 21 includes a bottom plate, side plates located on both sides of the bottom plate, and an inner end plate located at the inner end of the bottom plate. One end of the blister box limiting groove 21 (the end away from the tray fixing fixture) is open and faces outward, and is used to insert a blister box (not shown in the figure) into the blister box limiting groove 21 for storage.

[0130] In actual testing, there are often requirements for large-scale, multi-category testing. Figure 5 -Attached Figure 7 As shown, the number of the drawers 2 is multiple, preferably at least three layers, more specifically 10 layers, and each of the drawers 2 is formed with three side-by-side blister box limiting grooves 21, so that the storage device can store 30 blister boxes at the same time, and each blister box can hold multiple reagent strips, greatly improving the storage capacity.

[0131] Usually, the width of each of the blister box limiting grooves 21 is equal to the width of the blister box to ensure the stability of the limiting position, but this is inconvenient for placing the blister box into the blister box limiting groove 21. Figure 8 As shown, the outer frame 1 is provided with a guide groove 3 connected with the inlet end of each blister box limiting groove, and the guide groove 3 includes two guide blocks located on both sides of the inlet end of the dosage tray limiting groove 21, and a wedge-shaped groove space with a large opening end and a small inner end is formed between the two guide blocks. An indicator light 4 is provided at the inlet of each guide groove 3, and the indicator light 4 is used to indicate whether there is a blister box in the corresponding blister box limiting groove 21.

[0132] Although adding the guide groove 3 can reduce the difficulty of inserting the blister box, when the blister box is inserted into each of the blister box limit grooves 21, the drawer 2 will be opened under the action of the thrust, which is obviously disadvantageous for the operation of inserting the blister box. Figure 5 , Attachment Figure 7As shown, a first limiting mechanism 5 having a power source and at least limiting the opening of the drawer 2 is also provided on the outer frame 1, so that when the blister box is inserted into the blister box limiting groove 21, the drawer can be effectively prevented from opening. When the blister box is placed and needs to be opened subsequently, the first limiting mechanism 5 automatically releases the restriction on the opening action of the drawer 2, so that the drawer containing the blister box can be opened for corresponding operations.

[0133] Since there are multiple drawers 2, it is necessary to limit the opening of each drawer 2 when the blister box is inserted. In this embodiment, the first limiting mechanism 5 is used to limit the opening of all the drawers 2. The specific structure of the first limiting mechanism 5 will be described in detail below. Figure 5 , Attachment Figure 7 , Attachment Fig. 9 As shown, it includes a power source 51 that can generate linear movement in the vertical direction Z. The power source 51 can be a cylinder or a hydraulic cylinder or a linear moving device driven by a motor. The power source 51 is connected to a vertical rod 52 driven by it to move at a first height and a second height. The side of the vertical rod 52 is formed with a blocking block 54 that corresponds to the protrusion 53 on the side of each drawer 2. At the first height, the blocking block 54 is located in front of the protrusion 53 of the drawer 2 in the closed state (it is defined that during the opening process of the drawer 2, the position that the drawer passes first is the rear, and the position that the drawer passes later is the front), that is, the blocking block 54 is located on the moving path of the protrusion 53 when it is opened, so that the protrusion 53 is blocked by the blocking block 54 when it is opened and cannot continue to open; at the second height, the blocking block 54 is misaligned with the protrusion 53 in the vertical direction, so that the blocking block 54 does not block the movement of the protrusion 53.

[0134] In order to ensure the movement stability of the vertical rod 52, as shown in the attached Figure 5 As shown, a guide post (not shown in the figure) is arranged on the bracket, and the guide post is inserted into a waist-shaped hole extending in the vertical direction on the vertical rod 52; Figure 1 As shown, the vertical rod 52 is connected to a horizontal rod 55 perpendicular thereto, the horizontal rod 55 is connected to the power source 51, and two guide sleeves 56 are arranged on the horizontal rod 55, and a guide shaft 57 extending in the vertical direction is respectively inserted into the two guide sleeves 56, and the guide shaft 57 is fixed on the outer frame 1.

[0135] Furthermore, the outer frame 1 is provided with second limiting mechanisms corresponding to the number of the drawers 2, and each of the second limiting mechanisms can at least limit the opening of the corresponding drawer 2. Specifically, as shown in the attached Fig.10As shown, the second limiting mechanism includes a limiting pin 6 located on the side of each drawer 2, and the limiting pin 6 can move along its axial direction and is vertically arranged on a side plate 11 of the outer frame. The side plate 11 is provided with a through hole 12 for the limiting pin 6 to pass through, and a sleeve (not shown in the figure) can also be provided on the outer side of the side plate 11. The limiting pin 6 penetrates the sleeve and the side plate 11 in turn, and the limiting pin 6 is connected to a linear drive device (not shown in the figure) that drives it to move, such as a cylinder. In the first state, the linear drive device drives the limiting pin 6 to extend into the outer frame 1 and in front of the protrusion 53 on the drawer 2 in the closed state, which can effectively realize the limitation of the drawer 2. In the second state, the linear drive device drives the front end of the limiting pin 6 to be located on the outer side of the protrusion 53, thereby releasing the limitation on the movement of the protrusion 53.

[0136] Each of the second limiting mechanisms may have an independent linear drive device, but this requires multiple linear drive devices, which is disadvantageous for structural simplification and cost reduction. Therefore, in a more preferred embodiment, as shown in the attached Fig.10 As shown, a group of limiting pins 6 are driven by a linear drive device to move along their axial direction. At this time, the linear drive device needs to move to each limiting pin 6 in the vertical direction and connect with the limiting pin 6, and then drive the limiting pin 6 to move along its axial direction. At this time, the linear drive device can realize automatic and rapid connection and separation with the limiting pin 6 through a quick-connect structure such as a clamp or an electromagnet.

[0137] The lifting drive mechanism for driving the linear drive device to lift can be designed as needed. For example, it can use a non-sensing cylinder or hydraulic cylinder or electric push rod extending in the vertical direction Z to drive the linear drive device to lift. Fig.10 As shown, the lifting drive mechanism 7 includes a motor 71 fixed to the side of the frame, the output shaft of the motor 71 is coaxially connected to a driving wheel 72, the driving wheel 72 is lower than the bottom drawer, the driving wheel 72 is connected to a driven wheel 74 through a transmission belt 73, the driven wheel 74 is higher than the top drawer, the transmission belt 73 is connected to a connecting plate (not shown in the figure), the connecting plate is slidably arranged on a guide rail (not shown in the figure) extending along the vertical direction Z through a slider 75, the linear drive device is connected to the connecting plate, so that the forward and reverse rotation of the motor drives the belt to reverse forward and reverse, realizes the lifting and lowering of the connecting plate, and then drives the linear drive device to lift and lower to the limiting pins 6 at different positions for connection.

[0138] At the same time, each limiting pin 6 also cooperates with a second protrusion (not shown) on the side of the drawer 2 to limit the drawer 2 from closing, that is, when the drawer 2 is opened, the second protrusion is located in front of the limiting pin 6 in the second state, so that the limiting pin 6 limits the second protrusion and the drawer 2 cannot be closed. Of course, in other embodiments, the blocking block 54 of the first limiting mechanism can also cooperate with the second protrusion to prevent the drawer from closing.

[0139] Furthermore, a door (not shown in the figure) that can be opened and closed and covers at least all the drawers is also provided on the outer frame 1. The door and the drawers in the open state are located on the opposite side of the outer frame. The door can be opened when adding a reagent strip. After the reagent strip is placed in the limiting groove 21 of the blister box, the door is closed. The door can be an automatic door or a manual door. Its specific structure is a known technology and will not be described here.

[0140] When conducting subsequent tests, the drawer 2 needs to be opened to take out the reagent strips therein. In order to facilitate the automatic opening of the drawer 2, a magnetically attracted portion is provided at one end of each drawer 2 facing its opening direction. Subsequently, the opening mechanism can be connected to the drawer 2 by magnetic adsorption, and then the drawer 2 can be opened by applying a pulling force to the drawer 2.

[0141] Specifically, the opening and taking out of any of the drawers 2 is achieved by the multifunctional manipulator, as shown in the attached Figure 4 , Attachment Fig.11 As shown, the multifunctional manipulator moves on the inner side of the material storage device (towards the side of the pallet fixing fixture), and includes a mounting frame 8. The specific structure of the mounting frame 8 can be determined according to needs. In this embodiment, the mounting frame 8 at least includes a flat plate 81, and a first mounting member 82 is arranged on a first side of the flat plate 81, and a second mounting member 83 is arranged on a second side opposite to the first side.

[0142] As attached Fig.11 As shown, the first mounting member 82 is provided with an electromagnetic adsorption device 9, which is a device capable of generating magnetic force when powered, such as an electromagnet, an electromagnetic suction cup, etc., and its specific structure is a known technology and is not described here. The adsorption end of the electromagnetic adsorption device 9 faces outward, and when working, the electromagnetic adsorption device 9 can generate magnetic force to adsorb objects and drive the objects to move.

[0143] As attached Fig.11 As shown, the flat plate 81 is provided with a first clamping mechanism 20, and the first clamping mechanism 20 is located inside the electromagnetic adsorption device. Fig.12 , Attachment Fig.13As shown, the first clamping mechanism 20 includes two opposing claw bodies 201 and the clamping parts 2011 of the two claw bodies 201 are located below the first mounting member 82, so as to avoid interference during clamping. The two claw bodies 201 are connected to a driving mechanism that drives them to move, and the driving mechanism can be, for example, a clamping claw cylinder. In a more preferred embodiment, the driving mechanism includes a first motor 202 located on the plate 81, the motor shaft of the first motor 202 vertically passes through the plate 81 and is coaxially connected to a driving gear 203 located below the plate 81, the driving gear 203 is meshed with teeth on two moving blocks 204, the two moving blocks 204 are located on opposite sides of the driving gear 203, and they are movably arranged on a guide rail 206 extending along the first horizontal direction Y through a slider 205, and each slider 205 is fixed with a claw body 201, so that when the first motor 202 is started, the two moving blocks 204 are driven to move in opposite directions through the driving gear 203, so that the two claw bodies 201 are opened and closed.

[0144] When the first clamping mechanism 20 is used for clamping, it is necessary to first determine the position, type and other information of the object to be clamped. Fig.11 As shown, a code reader 10 is also provided on the mounting frame 8. The code reader 10 is specifically provided on the second mounting member 83 via a connecting member, and is tiltedly provided above the electromagnetic adsorption device 9, with its lens facing downward and toward the material storage device.

[0145] As attached Fig.11 As shown, a second clamping mechanism 30 is also provided on the mounting frame 8, the opening and closing direction of the second clamping mechanism 30 is perpendicular to the opening and closing direction of the first clamping mechanism 20, and the lower end of the claw body 301 of the second clamping mechanism 30 is higher than the lower end of the claw body 201 of the first clamping mechanism 20.

[0146] As attached Fig.14 As shown, the two claws 301 and 302 of the second clamping mechanism 30 can also be driven to open and close by a cylinder. In a more preferred embodiment, the claw 301 is fixed in horizontal position and close to the first clamping mechanism 20, and the other claw 302 can translate relative to the claw 301. The claw 302 reciprocates along the second horizontal direction X (perpendicular to the first horizontal direction Y) to adjust the distance between the claw 301 and the claw 302. The claw 302 is driven to move by a cylinder 303, the cylinder axis of the cylinder 303 extends along the second horizontal direction Y and is connected to the claw 302 through a transmission member 305, and the transmission member 305 is slidably arranged on a guide rail 306 extending along the second horizontal direction X.

[0147] The specific structure of the two claws 301, 302 can be designed according to the contour of the part in contact with the object. Fig.14 As shown, a square notch 3011 is formed on the claw body 301 at its lower right corner, and the claw body 302 includes a clamping portion 3021 corresponding to the notch 3011, and the end of the clamping portion 3021 is slightly higher than the end of the notch 3011. At the same time, the end surface of the clamping portion 3021 facing the claw body 301 is formed with a snap-fit ​​notch 3022, and a limiting rod 3033 is vertically arranged at its upper end, and the length of the limiting rod 3033 defines the minimum spacing between the two claw bodies 301 and 302.

[0148] In addition, in order to prevent the second clamping mechanism 30 from interfering with the object during use, as shown in the attached Fig.11 As shown, the second clamping mechanism 30 is connected to the first driving mechanism 304 that drives it to reciprocate along the vertical direction Z. The first driving mechanism 304 includes a second cylinder 3041. The cylinder axis of the second cylinder 3041 extends along the vertical direction Z. The cylinder axis of the second cylinder 3041 is connected to a lifting plate 3042. The lifting plate 3042 is slidably set on a longitudinal guide rail (not shown in the figure) on the vertical plate of the second mounting member 83. The cylinder 303 and the guide rail 305 are fixed on the lifting plate 3042.

[0149] The multifunctional manipulator is driven by a moving mechanism to move so as to adjust the position of the multifunctional manipulator to open and close drawers at different positions and to grab and move test strips at different positions of the drawers to the top of the tray, as shown in the attached Fig.15 As shown, the moving mechanism includes a stand 40, and the mounting frame 8 is arranged on the side (left side) of the stand 40 so as to be reciprocatingly movable along the vertical direction Z. Specifically, the mounting frame 8 is slidably arranged on a longitudinal track 401 extending along the vertical direction Z on the stand 40 through a slider, and a second driving mechanism 50 is arranged on the stand 40 to drive the mounting frame 8 to move along the vertical direction. The second driving mechanism 50 includes a lifting drive motor 501, the lifting drive motor 501 is fixed to the top of the stand 40 and its motor shaft extends along the first horizontal direction Y, the motor shaft is coaxially connected to a first transmission wheel 502, the first transmission wheel 502 is connected to a second transmission wheel 504 through a synchronous belt 503, and the second transmission wheel 504 is rotatably arranged at the bottom of the stand 40, and a clamping member 505 is arranged on the synchronous belt 503, and the clamping member 505 is arranged on the second mounting member 83 of the mounting frame 8.

[0150] As attached Fig.16 , Attachment Fig.17As shown, the vertical frame 40 is connected to a horizontal moving mechanism 100 that drives it to move along the first horizontal direction Y and the second horizontal direction X. The horizontal moving mechanism 100 can be various known structures. In a preferred embodiment, it includes a first translation drive mechanism 110 and a second translation drive mechanism 120. The first translation drive mechanism 110 includes a moving frame 116. A first translation motor 111 is provided at one end of the moving frame 116. The motor shaft of the first translation motor 111 is coaxially connected to a synchronous pulley 112. The synchronous pulley 112 is connected to a driven synchronous pulley 114 through a synchronous belt 113. The driven synchronous pulley 114 is rotatably arranged at the other end of the moving frame 116. A clamping block 115 is fixed on the synchronous belt 113. The clamping block 115 is fixed on the vertical frame 40, and the vertical frame 40 is slidably arranged on a horizontal track extending along the first horizontal direction Y through a sliding block 117. The second translation drive mechanism 120 has a similar structure to the first translation drive mechanism 110 , and also uses a motor, a synchronous wheel, a synchronous belt, a clamping block, a guide rail and other mechanisms to achieve the translation of the first translation drive mechanism 110 , which will not be described in detail here.

[0151] After the reagent strip in the material storage device is transferred to the tray 200 by the multifunctional manipulator, the protective cover on the reagent strip for protecting the probe needs to be opened for subsequent operations.

[0152] As attached Fig.18 As shown, the stand 40 is also provided with a cover opening mechanism 80, which is used to open the cover on the reagent strip. The cover opening mechanism 80 includes a first cover opening plate 801, and the first cover opening plate 801 is connected to a fourth driving mechanism 90 for driving the lifting thereof.

[0153] The lower part of the first cover opening plate 801 includes a group of equidistant cover opening push rods 802, and the number of the cover opening push rods 802 is preferably 10, so that the covers on multiple reagent strips can be opened at the same time.

[0154] At the same time, a second opening cover plate 803 is provided in a gap on the inner side of the first opening cover plate 801, and the lower end of the second opening cover plate 803 extends to the bottom of the first opening cover plate 801, and the gap between the second opening cover plate 803 and the first opening cover plate 801 is designed according to needs. When the protective cover for the reagent strip is opened, the gap between the second opening cover plate 803 and the first opening cover plate 801 is sufficient, and when the opening cover push rod 802 is embedded in the slot at the end of the protective cover, the second opening cover plate 803 contacts the end of the protective cover.

[0155] As attached Fig.18 , Attachment Fig.19As shown, the first cover opening plate 801 and the second cover opening plate 803 are both connected to the fourth driving mechanism 90, and the fourth driving mechanism 90 includes a vertical connecting plate 901, and the first cover opening plate 801 and the second cover opening plate 803 are arranged on both sides of the lower end of the vertical connecting plate 901, and the upper end of the vertical connecting plate 901 is connected to a connecting block 902, and the connecting block 902 is connected to a movable nut of a second lead screw 903 and is slidably arranged on a second guide rail (not shown in the figure) extending along the vertical direction Z, and the screw of the second lead screw 903 is rotatably arranged on the stand 40 and located on the side (right side) of the lead screw 703, and the screw of the second lead screw is connected to a motor 904 that drives it to rotate.

[0156] After opening the protective cover on the reagent strip, the probe needs to be removed from the probe hole and placed in the probe receiving hole on the tray for subsequent operation. Fig.18 As shown, a probe clamp 60 is also provided on the stand 40, and the probe clamp 60 and the mounting frame 8 are located on opposite sides of the stand 40. The probe clamp 60 is connected to a third driving mechanism 70 that drives it to reciprocate along the vertical direction Z, so that the mechanism that drives the translation of the probe clamp 60 and the structure that drives the translation of the multifunctional manipulator form a set of structures. Of course, in other embodiments, the probe clamp 60 can also adopt a set of independent translation structures, but this is obviously not economical.

[0157] Specifically, as shown in the attached Fig. 20 As shown, the probe clamp 60 includes a second motor 601, the motor shaft of the second motor 601 extends longitudinally and is eccentrically connected to a transmission member 602, a rotating member 603 that can rotate relative to the transmission member 602 is coaxially connected, the rotating member 603 can be, for example, a bearing, the rotating member 603 is embedded in a mounting groove (not shown in the figure) of the first clamping block 604, the aperture of the mounting groove is equivalent to the outer diameter of the rotating member 603, the first clamping block 604 is movably arranged on a guide rail 605 extending along a second horizontal direction X, the guide rail 605 is fixed on a fixed block 606, and the fixed block 606 is also provided with a second clamping block 607 that cooperates with the first clamping block 604 for clamping.

[0158] When working, the second motor 601 drives the transmission member 602 to rotate and drives the rotating member 603 to rotate. Since the transmission member 602 and the rotating member 603 are eccentrically arranged, the rotating member 603 revolves around the axis of the rotating member 602, thereby driving the first clamping block 604 to move back and forth along the guide rail 605, thereby changing the distance between the first clamping block 607 and the second clamping block 607 to realize the opening and closing of the probe clamp.

[0159] As attached Fig.18As shown, the fixed block 606 is connected to a third driving mechanism 70 that drives it to reciprocate along the vertical direction Z. Specifically, the third driving mechanism 70 includes a carrier plate 701 for fixing the fixed block 606, and the carrier plate 701 is connected to a movable nut of a lead screw 703 through an adapter block 702. The screw of the lead screw 703 extends along the vertical direction Z and its two ends are rotatably arranged on the stand 40. One end of the screw is connected to a motor 704 that drives it to rotate and is fixed on the stand 40, and is slidably arranged on the vertical rail 702. The adapter block 702 is also connected to a sliding block 705, and the sliding block 705 is slidably arranged on a slide rail 706 extending along the vertical direction Z, and the slide rail 706 is arranged on the stand 40.

[0160] Of course, in other embodiments, the third driving mechanism 70 may also be implemented by a rodless cylinder, a hydraulic cylinder, an electric push rod or the like.

[0161] In addition, after the reagent strip is transferred to the tray 200 by the multifunctional robot, the protective film on the reagent strip needs to be opened so that the notches of each slot on the reagent strip can be exposed for subsequent operations.

[0162] Therefore, if the attached Fig.21 , Attachment Fig. 22 As shown, it also includes a film opening device 400 for puncturing the protective film of the reagent strip on the tray, and the film opening device 400 includes a row of film opening cones 410 arranged along the extension direction of the limiting groove 210, and the film opening cones 410 are vertically arranged, and they are normally located above the tray 200. The number of the film opening cones 410 is consistent with the number of material slots on the reagent strip and corresponds one to one, so that the film opening cones 410 can complete the film opening of all material slots on a reagent strip at one time, and a row of the film opening cones 410 is located below a vertical plate 440 and the vertical plate 440 is connected to a film opening drive device 420 for driving its vertical movement and a horizontal drive device 430 for driving the film opening drive device 420 for horizontal movement.

[0163] Among them, as attached Fig. 22 As shown, the film opening drive device 420 includes a cylinder 421, the cylinder axis of the cylinder 421 is vertically arranged and fixed on a sliding table 422 located on the outside of the pallet fixing fixture 200, and the body of the cylinder 421 is slidably arranged on a first longitudinal guide rail 424 extending in a vertical direction (a direction perpendicular to both the first horizontal direction Y and the second horizontal direction X) through a first slider 423, and the first longitudinal guide rail 424 is fixed to the side of the sliding table, and a Z-shaped mounting rod 425 for mounting the film opening cone 410 is fixed on the first slider 423, and the mounting rod 425 extends out of the side of the sliding table close to the pallet fixing fixture 200.

[0164] As attached Fig. 22 As shown, the horizontal driving device 430 includes a motor 431, and the motor 431 is connected to a horizontal lead screw 432 perpendicular to the limit groove and drives the screw of the horizontal lead screw 432 to rotate. The interactive nut of the horizontal lead screw 432 is connected to the sliding table 422, and the sliding table 422 is slidably set on two horizontal rails 423 parallel to the horizontal lead screw 432.

[0165] Furthermore, in order to prevent the reagent strip from being displaced or moved out of the limiting groove of the tray under the action of the lifting force when the cover is opened, it is necessary to apply downward pressure to the reagent strip on the tray to prevent the reagent strip from being pulled up, as shown in the attached Fig. 22 As shown, a pressure rod 500 is also provided on the sliding table 422, and the extension direction of the pressure rod 500 is perpendicular to the extension direction of the limiting groove, and the length of the pressure rod 500 is not less than the sum of the widths of all the limiting grooves 210, and the pressure rod 500 is connected to a downward pressure driving mechanism 600 that drives it to move vertically. The downward pressure driving mechanism 600 has the same structure as the above-mentioned film opening driving device 420, and includes a lifting cylinder 610, and the cylinder shaft of the lifting cylinder 610 is fixed on the sliding table 422. The cylinder body of the cylinder 610 is slidably disposed on a second longitudinal guide rail 630 extending in the vertical direction through a second slider 620. The second longitudinal guide rail 630 is fixed to the side of the sliding table 422. A Z-shaped mounting rod 640 for mounting the pressure rod 500 is fixed on the second slider 620. Therefore, the pressure rod 500 moves synchronously with the film opening cone, and they share a set of structures that drive them to move in translation. Of course, in other embodiments, the pressure rod 500 can also adopt an independent translation drive mechanism.

[0166] After opening the protective film on the reagent strip, opening the protective cover, and transferring the probe, the test liquid needs to be added to the corresponding slot on the reagent strip to achieve the corresponding reaction. Figure 3 As shown, the pre-treatment device also includes a test liquid storage mechanism 2000, which is located on the side of the material storage device 100 and has a group of containers. The containers can be selected according to needs, for example, they can be test tubes, liquid storage bottles, etc., which are arranged on a container rack. At the same time, the container rack can reciprocate along the second horizontal direction X, and the container rack is connected to a cylinder that drives it to move.

[0167] As attached Figure 3 As shown, the pre-treatment device also includes an injection mechanism 3000, which has a structure that can extend into any of the containers to absorb liquid and inject it into the groove of the material on the tray.

[0168] Specifically, as attached Fig.23As shown, the injection mechanism 3000 at least includes a vertical nozzle connecting tube 02, a suction injection mechanism connected to the upper end of the nozzle connecting tube 02, the nozzle connecting tube is connected to a mechanism driving it to move horizontally along a first horizontal direction Y and / or a second horizontal direction X and along a vertical direction Z, and the suction injection mechanism moves horizontally synchronously with the nozzle connecting tube.

[0169] As attached Fig.24 As shown, the nozzle connecting tube 02 is used to connect with the nozzle when in use, and is a cylindrical tube as a whole. In order to facilitate the connection with the nozzle, the lower part of the nozzle connecting tube 02 includes a spherical head 021, a thin straight tube section 022, a conical tube section 023 and a thick straight tube section 024 arranged in sequence from bottom to top.

[0170] As attached Fig.23 As shown, the nozzle connecting tube 02 is connected to a moving mechanism 04 which drives the moving mechanism 04 to move in at least one of a first horizontal direction Y and a second horizontal direction X perpendicular to the first horizontal direction, and a vertical direction Z. The moving mechanism 04 can be various feasible structures, such as a six-axis robot or a four-axis robot.

[0171] In a more preferred embodiment, as shown in the attached Fig.24 As shown, the moving mechanism 04 includes a mounting block 041, the nozzle connecting tube 02 is arranged on the mounting block 041, the mounting block 041 is slidably set on a guide track 043 extending along the vertical direction Z through a sliding block 042, the guide track is fixed on a mounting stand 044, the mounting block 041 is connected to a belt 045, the belt 045 is sleeved on two synchronous wheels 046, the installation height of the two synchronous wheels is designed according to the required lifting height of the nozzle connecting tube 02, the synchronous wheel located in the lower position is fixed to the lower end of the mounting stand 044, and the synchronous wheel 045 located in the upper position is coaxially connected to the motor shaft of a lifting motor 047, and the lifting motor 047 is fixed in position, so that the moving mechanism drives the nozzle connecting tube to be infinitely raised along the vertical direction.

[0172] As attached Fig.23 , Attachment Fig.24 As shown, the mounting frame 044 is directly or through other supporting members connected to two sliding members 048 located on opposite sides thereof, and the two sliding members 048 are slidably mounted on two guide strips 049 extending along the first horizontal direction Y, and one of the sliding members 048 is connected to a transmission belt 0410 through a connecting member, and the transmission belt 0410 is mounted on two driving rollers 0420, one of which is rotatably arranged on the translation frame 0430, and the other driving roller is coaxially connected to the first translation motor 0440 fixed on the translation frame 0430.

[0173] As attached Fig.23 As shown, the translation frame 0430 is slidably arranged on the hanging frame 0450, and the hanging frame 0450 is provided with a driving mechanism for driving the translation frame 0430 to reciprocate along the second horizontal direction X. The driving mechanism also adopts a structure composed of a motor 0460, a synchronous wheel 0470, and a synchronous belt 0480, which will not be described in detail here. Of course, the driving mechanism can also adopt devices such as a rodless cylinder and a linear motor.

[0174] Further, in order to prevent the nozzle connecting tube 02 from excessively moving downward when the nozzle connecting tube 02 is plugged into the nozzle, causing damage to the nozzle, in a more preferred embodiment, as shown in the attached Fig.24 As shown, the nozzle connecting tube 02 can be movably inserted into the mounting block 041 along the vertical direction Z and a limiting block 025 located on the mounting block 041 is provided on the nozzle connecting tube 02, so that the nozzle connecting tube will not fall from the mounting block 041. Furthermore, a boss 026 located below the mounting block 041 is formed on the outer wall of the nozzle connecting tube 02, and a spring 08 is provided between the boss 026 and the mounting block 041 and is sleeved on the outer periphery of the nozzle connecting tube.

[0175] After the nozzle connecting tube 02 is connected to the nozzle, it is necessary to perform aspiration and injection operations. Fig.23 , Attachment Fig.24 As shown, the upper end of the suction nozzle connecting tube 02 is connected to the suction injection mechanism 07, and the suction injection mechanism 07 moves along with the suction nozzle connecting tube 02. Fig.24As shown, the suction injection mechanism 07 includes a transfer tube (not shown in the figure) having one end connected to the upper end of the suction nozzle connecting tube, the transfer tube can be a hose or a telescopic tube, etc., the other end of the hose is connected to the inlet and outlet of a syringe 071, the syringe 071 is horizontal, and its axis is perpendicular to the axis of the suction nozzle connecting tube 02, the piston rod 072 of the syringe 071 is connected to a push-pull mechanism 073 that drives it to reciprocate along its axis, the push-pull mechanism 073 can be various known feasible structures, for example, it can be a hydraulic cylinder or an electric push rod and other devices, which can drive the piston rod 072 to move steplessly to flexibly control the amount of each injection. Preferably, the push-pull mechanism 073 includes a push-pull drive motor 0731, the length of the motor shaft 0732 of the push-pull drive motor 0731 extending outside its housing is not less than the moving stroke of the piston rod 072, and the motor shaft 0732 is provided with a movable nut 0733, and the movable nut 0733 switches the rotational motion of the motor shaft to its own linear motion. Specifically, the movable nut 0733 and the motor shaft 0732 form a screw structure, and the movable nut 0733 is connected to the piston rod 072. Further, the movable nut 0733 is movably arranged on a guide track 0735 parallel to the motor shaft through a sliding seat 0734.

[0176] Preferably, in order to effectively control the precision of aspiration and injection, Fig.24 As shown, a valve body 074 is connected between the hose and the syringe. The valve body 074 is an adjustable solenoid valve, and the valve body is fixed on a valve seat 075. The valve seat 075 is fixed on the mounting stand 044. The valve seat 075 has a channel connected to the inlet and outlet of the syringe and the valve body, so that the injection volume can be adjusted by controlling the flow of the valve body 074.

[0177] As attached Fig.23 , Attachment Fig.24 As shown, the nozzle connecting tubes 02 are preferably two and can be raised and lowered separately and are respectively connected to one of the suction and injection mechanisms 07. The structure for driving the two nozzle connecting tubes 02 to rise and fall and the two suction and injection mechanisms 07 are symmetrically arranged on the mounting stand.

[0178] During the test, if only one or two test liquids need to be sucked, the nozzle can be manually plugged into the nozzle connecting tube without replacement. However, in actual work, a variety of different test liquids are often sucked. The test liquids may be body fluids of the human body or other liquid medicines required for the test according to different test needs. Obviously, the nozzle that has sucked one test liquid cannot be used for the injection of another test liquid. Therefore, the nozzle on the nozzle connecting tube needs to be replaced. Fig.25 -Attached Fig.28As shown, in order to facilitate automatic replacement, the automatic injection device also includes a feeder 06, which includes a limit plate 061 located within the moving range of the nozzle connecting tube 02 and perpendicular to the nozzle connecting tube. The limit plate 061 is fixed on the feeder trough 062. The limit plate 061 is formed with at least one perforation 063 and a feeder hole 064 connected to the perforation. Preferably, there are two perforations 063, each of which is connected to a feeder hole, and the four holes are connected. When the nozzle connecting tube 02 is coaxial with the perforation 063, its outer wall is spaced from the hole wall of the perforation 063. The distance between the two ends 065 and 066 of the feeder hole 064 connected to the perforation 063 is less than or equal to the aperture of the perforation 063. The limit plate 061 is fixed on the feeder trough 062, and the bottom feeder port of the feeder trough 062 is connected to the notch at the top of a waste collection trough 09.

[0179] As attached Fig. 27 As shown, when the through hole 063 is a circular hole for the suction nozzle to pass through, the discharge hole 064 is a rectangular hole, and the spacing between the two ends 065 and 066 is the width of the rectangular hole and is smaller than the diameter of the through hole 063, or, the discharge hole 064 may also be a triangular hole or a trapezoidal hole, etc., so that when the suction nozzle connecting tube 02 moves to the discharge hole 064, the top of the suction nozzle is located outside the two sides of the discharge hole 064, and then when the suction nozzle connecting tube 02 moves upward, the suction nozzle is blocked by the limiting plate 061 and separated from the suction nozzle connecting tube 02.

[0180] After the suction nozzle on the suction nozzle connecting pipe is unloaded, a new suction nozzle needs to be replaced. Therefore, an automatic suction nozzle supply mechanism is also provided next to the material storage device (on the left side).

[0181] As attached Fig.28 -Attached Fig.32 As shown, the automatic nozzle supply mechanism includes

[0182] The storage bin 01 has a storage space 011 for storing multi-layer stacked material boxes 001. The bottom of the storage bin is a discharge port 012. The material boxes can be moved out of the storage bin 01 from the discharge port 012 under the action of gravity.

[0183] The material box 001, when the material box is in the storage space 011, its side wall is close to the inner wall of the storage bin 01, and the side wall of the material box 001 includes a first side wall 0011 located at the top and a second side wall 0012 located below the first side wall and having a height less than the first side wall 0011, the distance between the first side wall 0011 and the inner side surface of the storage bin 01 is greater than the distance between the second side wall 0012 and the inner side surface of the storage bin, the second side wall 0012 is close to or fits the inner side surface of the storage bin 01, and its height is about half of the first side wall 0011. When stacked, the second side wall area of ​​the upper material box is set in the first side wall area of ​​the lower material box.

[0184] The conveying jig 03 can move between a first horizontal position and a second horizontal position. In the first horizontal position, it is located a certain distance below the storage bin 01 and corresponds to the unloading port of the storage bin; in the second horizontal position, it is located on the outside of the storage bin and directly below it is the slot of the waste collection trough 09, and the material box 001 separated from the conveying jig can directly fall into the waste collection trough 09.

[0185] The automatic unloading mechanism 05 can move the multi-layer stacked material boxes 001 one by one to the conveying fixture at the first horizontal position. It includes two symmetrically arranged clamping arms that can be raised and lowered between the unloading port of the storage bin and the conveying fixture. In the first state, as shown in the attached Fig.31 , Attachment Fig.33 As shown, the opposing surfaces 0511, 0512 of the two clamping arms 051 are located on the outside of the two opposite sides 0121, 0122 of the discharge port 012. At this time, the clamping arms do not provide support for the material box 001 located in the storage bin; in the second state, the opposing surfaces 0511, 0512 of the two clamping arms are located on the inside of the two opposite sides 0121, 0122 of the discharge port. At this time, the clamping arms provide support for the material box 001 located in the storage bin.

[0186] In a preferred embodiment, as shown in the attached Fig.31 As shown, the storage bin 01 is a rectangular parallelepiped assembled from three side panels 013 and a top panel 014 with an open bottom and one side. The area enclosed by them is the storage space 011. The opening on the side of the storage bin 01 is arranged to face outward to facilitate adding material boxes 001 into the storage space 011.

[0187] As attached Fig.32As shown, the storage bin 01 is provided with a door 015 which can cover at least part of the side opening, and the specific structure of the door 015 can be designed as needed. In addition, the storage bin 01 is provided with a locking device for keeping the door in a closed state. Specifically, a connecting plate 016 is vertically provided on the side of the main baffle of the door 015, and a lock hole 017 is opened on the connecting plate 016. The locking device includes a locking pin (not shown in the figure) that is vertically penetrated through the side plate 0131 and corresponds to the lock hole 017 on the door in a closed state. The locking pin has a pointed end facing the connecting plate 016, and the locking pin is connected to a driving cylinder 018 that drives it to reciprocate and extend along its axial direction. When the driving cylinder 018 is fixed on the side plate 0131 and drives the locking pin to be inserted into the lock hole 017, the door 015 is locked; when the driving cylinder 018 drives the locking pin to withdraw from the lock hole 017, the door 015 can be opened.

[0188] In a more preferred embodiment, the door 015 is connected to an elastic device that drives it to automatically open from a closed state. The elastic device can be a torsion spring (not shown in the figure). The specific installation method is a known technology and is not described here. The torsion spring deforms and accumulates force when the door 015 is closed. When the locking pin releases the lock on the door 015, the accumulated energy is released and reset, so that the door 015 automatically opens.

[0189] The conveying jig 03 is used to convey the material box 001 dropped from the storage bin 01 to the outside of the storage bin 01 for use. Fig.30 As shown, it specifically includes a bottom plate 031, on which a limiting structure for limiting the material box 001 is provided, such as a plurality of limiting blocks, a plate, a limiting pin, etc., which are specifically designed according to the structure of the material box 001 to be transported, and are not limited here. The distance from the bottom plate 031 to the bottom of the side plate of the storage bin 01 is designed according to the height of the material box 001, so that when the material box 001 falls on the bottom plate 031, it can be moved out from the bottom of the storage bin 01.

[0190] As attached Fig.30 As shown, the bottom plate 031 can be slidably disposed in a guide groove 033 provided on two parallel vertical plates 032 and is connected to a translation driving mechanism 034 which drives it to translate along the guide groove 033. Each of the vertical plates 032 is integrally formed with a side plate 013 of the storage bin 01. Of course, they can also be connected through a connecting plate, or they can be not connected.

[0191] As attached Fig.30As shown, one of the two guide grooves 033 is a through groove, and the base plate 031 has a connecting portion 035 passing through the through groove. The portion of the connecting portion 035 extending to the outside of the vertical plate is connected to a movable nut of a lead screw 036, and the movable nut is also slidably connected to a slide rail 038 located on the outer side of the vertical plate through a guide block 037. The screw of the lead screw 036 is connected to a motor 039 that drives it to rotate, and the motor 039 is fixed to the outer side of the vertical plate.

[0192] The motor, lead screw, guide block 037 and slide rail 038 constitute the translation drive mechanism 034. When working, the motor 039 drives the movable nut of the lead screw 036 to translate, thereby driving the bottom plate 031 to move, thereby achieving the overall translation of the conveying fixture. Of course, in other embodiments, the translation drive mechanism 034 can also use a rodless cylinder or hydraulic cylinder or other device that can generate linear movement to replace the structure of the motor and the lead screw.

[0193] And when the conveying jig 03 moves to the second horizontal position, the two vertical plates are provided with a limiting surface extending between them, and the limiting surface is slightly higher than the top surface height of the side wall of the material box 001 on the conveying jig 03, and the limiting surface is the bottom surface of the two height limiting blocks 0310.

[0194] The automatic unloading mechanism 05 is used to transfer the material boxes 001 in the storage bin 01 to the conveying jig 03, and when the conveying jig 03 moves to the outside of the storage bin 01, it provides support for other material boxes 001 to prevent them from falling.

[0195] Specifically, as attached Fig.34 As shown, the two clamping arms 051 of the automatic unloading mechanism 05 are horizontal, and the side panels and the vertical panels are provided with avoidance gaps for the movement of the clamping arms 051. Each clamping arm 051 is connected to a vertical rod 052 that is L-shaped therewith, and the vertical rod 052 is located on the outer side of the open side panel 0133 on the opposite side of the storage bin 01. The upper end of the vertical rod 052 is connected to a mounting block 053, and the mounting block 053 is slidably arranged on a guide rail 055 extending along a direction perpendicular to the moving direction of the conveying jig 03 through a slider 054, and the guide rail 055 is fixed on the side panel 0133, and a spring 056 is arranged between the two mounting blocks 053, and the two ends of the spring 056 are respectively fixed on the two springs 056, and the spring 056 keeps the two clamping arms in the second state under normal conditions.

[0196] Of course, in other embodiments, the two clamping arms 051 can also be connected to two sliding blocks of a clamping cylinder by a bracket.

[0197] In a more preferred embodiment, as shown in the attached Fig.34 As shown, the guide rail 055 is fixed on an adapter block 057, and the adapter block 057 is connected to a lifting drive device 058 that drives it to rise and fall. The lifting drive device 058 can be a cylinder, or other devices that can produce linear movement, such as a hydraulic cylinder, etc. The adapter block 057 is guided by a guide shaft and a bushing.

[0198] In a more preferred embodiment, in order to realize the automatic opening and closing of the two clamping arms 051, as shown in the attached Fig.34 , Attachment Fig.35 As shown, each of the mounting blocks 053 is rotatably provided with a roller 059 at the side facing the storage bin 01, the axis of the roller 059 extends along the moving direction of the conveying jig, and the two rollers 059 are respectively embedded in a groove 0510, and the groove 0510 includes a vertical section 0520 and an inclined section 0530. When the roller 059 is in the vertical section 0520, the two clamping arms maintain a first state, that is, the two clamping arms maintain a closed state, and can provide support for the material box 001 thereon. When the roller is at the end of the inclined section 0530, the two clamping arms maintain a second state, that is, the two clamping arms are in an open state, and do not support the material box 001 thereon. At this time, the clamping arms maintain a certain distance from the top of the conveying jig 03 so that the material box falls onto the conveying jig 03, so that other material boxes can be clamped and lifted when the clamping arms are closed subsequently.

[0199] At the same time, when the roller moves to the end of the inclined section 0530, the clamping arm 051 is as close to the top surface of the conveying jig as possible so as to minimize the drop of the material box from the clamping arm to the conveying jig.

[0200] As attached Fig.35 As shown, a high-positioned arc-shaped notch 0540 is formed on the side of the vertical section, and the distance between the two arc-shaped notches 0540 is smaller than the distance between the two vertical sections 0520 , so that the two clamping arms can better provide support for the material box 001 thereon.

[0201] Preferably, in order to reduce the translation stroke of the nozzle connecting tube of the injection mechanism, the tray needs to be moved to a position close to the nozzle connecting tube, so the pre-processing device also includes the following Figure 3 As shown,

[0202] A pallet positioning fixture h, having a limiting structure for positioning the pallet;

[0203] The pallet transfer mechanism has a structure for moving the pallet between the pallet fixing jig 300 and the pallet positioning jig h.

[0204] Specifically, as attached Figure 3 As shown, the pallet positioning fixture h is located inside the nozzle automatic supply mechanism and adjacent thereto, and the pallet positioning fixture h is opposite to the pallet fixing fixture 300 in the second horizontal direction X, thereby simplifying the structure of the moving part of the pallet transfer mechanism.

[0205] As attached Fig.36 As shown, the tray transfer mechanism includes

[0206] The pallet clamp c comprises two clamping rods c1 of equal height and extending horizontally and an opening and closing driving device for driving them to open and close, wherein the clamping rods c1 are perpendicular or parallel to the blanking plate b;

[0207] A jaw flipping mechanism d, connected to the pallet jaw c and driving it to rotate around an axis perpendicular or parallel to the blanking plate;

[0208] The moving mechanism e drives the clamping and flipping mechanism to move horizontally and up and down within a predetermined range.

[0209] The pallet clamp c is used to clamp the pallet 200 to facilitate the subsequent movement of the pallet 200. Fig.36 , Attachment Fig.37 As shown, the extension direction of the two clamping rods c1 is preferably perpendicular to the blanking plate b, and the clamping rods c1 are formed with positioning pins c11 corresponding to the notches on the tray, and the two clamping rods c1 are driven to open and close by a double-headed motor c2. The specific structure of the opening and closing drive device is as follows:

[0210] As attached Fig.37 As shown, a translation block c3 is respectively provided on the motor shaft extending outside the two ends of the double-headed motor c2, and the translation block c3 can switch the rotational motion of the motor shaft into its own linear motion. For example, the translation block c3 and the motor shaft form a screw structure, and the translation block c3 is connected to the clamping rod c1 through a transfer block c4, and the clamping rod c1 is connected to the transfer block c4 through an L-shaped connecting block at its tail end, and the connecting block is fixed to a slider c5, and the slider c5 is slidably arranged on a horizontal guide rail c6 that is perpendicular to the supporting rod c1.

[0211] Further, as attached Fig.37 As shown, in order to effectively support the motor shaft, the motor shaft of the double-headed motor c2 extending outside the two ends is rotatably arranged on the support plates c71 on both sides of the motor base c7.

[0212] As attached Fig.37 As shown, the clamping jaw turning mechanism d is a rotating cylinder connected to the motor base c7 or a turntable driven by a motor, and the axis of the rotating cylinder or the motor is parallel to the extension direction of the clamping rod c1.

[0213] As attached Fig.36 As shown, the moving mechanism e is used to drive the pallet clamp to move within a predetermined range, which can enable the clamping rod of the pallet clamp to move between the upper and lower positions of the blanking plate b and drive the clamping rod to move outside the blanking plate b to correspond to the position of the blanking plate in the vertical direction, that is, the clamping rod can extend from one side of the blanking plate to the other side.

[0214] As attached Fig.36 As shown, the moving mechanism e includes a lifting drive mechanism that drives the clamping claw flipping mechanism to reciprocate in the vertical direction and a horizontal drive mechanism that drives the lifting drive mechanism to move horizontally in a direction parallel to the blanking plate. The lifting drive mechanism and the horizontal drive mechanism respectively use motors as power sources.

[0215] Specifically, as attached Fig.36 As shown, the lifting drive mechanism includes a sliding seat e1, which is slidably arranged on a guide rail e2 extending along the vertical direction z, and the sliding seat e1 is connected to a belt e3, and the belt 13 is mounted on two rollers (not shown in the figure), and the axes of the rollers are perpendicular to the blanking plate b. One of the rollers is located above the pallet positioning fixture h and is fixed on the sliding frame e4, and the other roller is located below the blanking plate and is coaxially connected to the lifting drive motor e5, and the lifting drive motor e5 is fixed on the sliding frame e4.

[0216] The sliding frame e4 is connected to the horizontal driving mechanism, and the structure of the horizontal driving mechanism is the same as that of the lifting driving mechanism. The sliding frame e4 is also driven by a translation motor, a belt, and a pulley to move along a horizontal guide rail e6 parallel to the blanking plate. The horizontal guide rail e6 extends along the first horizontal direction Y and its two ends extend to the outside of the pallet positioning fixture and the pallet fixing fixture. The horizontal guide rail is fixed on a side plate (not shown in the figure). The moving mechanism e can drive the pallet clamp to place the pallet on the pallet positioning fixture h.

[0217] Furthermore, after the test is completed, the reagent strip on the tray 200 needs to be unloaded from the tray 200 to facilitate the reuse of the tray 200. Fig.36 As shown, the pre-processing device also includes a blanking plate b, which is vertically arranged and perpendicular or parallel to the limiting groove of the pallet on the pallet fixing fixture, as shown in the attached Fig.38 As shown, its lower end surface is a group of planes b1-b10 with height differences.

[0218] As attached Fig.36As shown, the blanking plate b is fixed to the bottom of a horizontal carrier plate f, an automatic turntable g is provided on the carrier plate f, a tray positioning fixture h is provided on the turntable g, and the automatic turntable g is used to drive the tray 200 to rotate 90° around the axis of the automatic turntable so as to quickly add the test liquid to the reagent strip on the tray through the test liquid adding mechanism.

[0219] As attached Fig.39 , Attachment Fig.40 As shown, the automatic turntable g includes a rotating seat g1 rotatably arranged on the carrier plate, a rotating shaft g11 of the rotating seat g1 is rotatably arranged on the carrier plate f through a bearing (not shown in the figure), a seat plate g12 is arranged on the top of the rotating shaft g11 and a transmission wheel g2 located between the carrier plate f and the seat plate is mounted thereon, the transmission wheel g2 is connected to a driving wheel g4 through a transmission belt g3, the diameter of the driving wheel g4 does not exceed 1 / 4 of the diameter of the transmission wheel g2, the driving wheel g4 is coaxially connected to the motor shaft of a motor g5, the motor g5 is fixed to the bottom of the carrier plate f, and the motor shaft vertically passes through the carrier plate f.

[0220] In addition, as attached Fig.40 As shown, an adjusting block g6 is further provided on the top surface of the carrier plate f, and the adjusting block g6 is adjustably arranged on the carrier plate f through the waist-shaped hole thereon. A tensioning wheel g7 is rotatably arranged on the adjusting block g6, and the axis of the tensioning wheel g7 is parallel to the axis of the motor, and the wheel surface of the tensioning wheel is in contact with the transmission belt g3. The transmission belt g3 can be tensioned by adjusting the position of the tensioning wheel g7.

[0221] In a more preferred embodiment, as shown in the attached Fig.39 As shown, a gantry guide frame g8 is also provided on the carrier plate f, and the rotating shaft g11 is rotatably connected to the gantry guide frame g8 via a bearing.

[0222] During operation, the tray clamp c clamps the tray 200 from both sides of the tray 200 through two clamping rods c1, and then the clamp flipping mechanism d drives the tray clamp c to drive the tray 200 to flip 180°, so that the bottom of the tray 200 faces upward, and then the moving mechanism e drives the tray clamp c to drive the tray 200 to move to the bottom of the unloading plate b, and makes the unloading plate b correspond to a reagent strip limiting groove 210 of the tray 200, and then continues to lift the tray 200, so that the lower end surface of the unloading plate b contacts the reagent strip in the reagent strip limiting groove, and as the tray 200 continues to rise, the reagent strip can be pressed out of the reagent strip limiting groove 210 where it is located to complete the unloading.

[0223] Alternatively, in another embodiment, the blanking plate b can be made to correspond to the gap 215 on the tray 200 that is perpendicular to the reagent strip limiting groove, and then the moving mechanism e drives the tray 200 to continue to rise, so that the blanking plate b can apply a thrust to one end of the multiple reagent strips, thereby squeezing the multiple reagent strips out of the corresponding reagent strip limiting grooves to complete the blanking. In addition, since the lower end surface of the blanking plate b is a plurality of planes with a height difference, its different positions can contact the corresponding reagent strips in a certain order, so that the blanking can be performed at different times. Compared with the planar blanking method, this structure is more labor-saving and conducive to ensuring the reliability of blanking.

[0224] In addition, when the device is actually used, there can be multiple trays 200, so that when the reagent strip enters the test loading for testing, the reagent strip can be transferred, the film can be opened, the cover can be opened, and the test liquid can be injected on the tray positioning fixture at the same time.

[0225] During the automatic operation of the entire equipment, the automatic operation of each mechanism can be controlled by control devices such as PLC in combination with various sensors. The corresponding structure and control technology are known technologies and are not the focus of this solution, so they will not be elaborated here.

[0226] The present solution also discloses a medical device, comprising the pre-test processing device of the above embodiment.

[0227] This solution further discloses a detection method, which comprises at least the following steps:

[0228] S1, the pallet is fixed on the pallet fixing fixture.

[0229] S3, the material supply mechanism moves at least one material to a limiting groove of the tray for limiting;

[0230] The S3 specifically includes

[0231] S30 , manually placing at least one tray carrying reagent strips into the reagent strip tray limiting groove 21 of the drawer. At this time, the sensor corresponding to the reagent strip tray limiting groove 21 determines that there is a tray in the reagent strip tray limiting groove 21 .

[0232] S31, the control device controls the horizontal moving mechanism 100 and the second driving mechanism 50 of the multifunctional manipulator to drive the electromagnetic adsorption device 9 to move to the drawer with the tray, and energizes the electromagnetic adsorption device to generate magnetic force to adsorb the drawer, and then the horizontal moving mechanism 100 drives the electromagnetic adsorption device 9 to translate to open the adsorbed drawer, and after opening, the electromagnetic adsorption device 9 is powered off. The drawer is limited to close from the open state by the first limiting mechanism or the second limiting mechanism on the reagent strip storage device.

[0233] S32, then, the control device controls the barcode reader on the multifunctional manipulator to start reading the barcode on the reagent strip in the tray to determine the type, quantity and position of the reagent strip.

[0234] S33, then, according to the determined number and position of the reagent strips, the horizontal moving mechanism and the second driving mechanism 50 are controlled to move the multifunctional manipulator, and the reagent strips in the tray are clamped one by one and moved out of the drawer through the first clamping mechanism 20 and the second clamping mechanism 30 thereon. At this time, the first clamping mechanism 20 clamps on both sides of the reagent strip, and the second clamping mechanism 30 clamps on both ends of the protective cover at the end of the reagent strip.

[0235] S34, after the reagent strip is moved out of the drawer, the first limiting mechanism or the second limiting mechanism releases the restriction on the drawer, and the control device controls the horizontal moving mechanism 100 and the second driving mechanism 50 of the multifunctional manipulator to drive the electromagnetic adsorption device 9 to move and close the drawer where the reagent strip is transferred.

[0236] If the material used is not a test strip and does not have a protective film or a protective cover, the test liquid can be directly added to the groove on the material.

[0237] S5, at this time, the liquid can be sucked from the designated container by the injection mechanism and injected into the groove of the material on the tray according to the metered amount.

[0238] Furthermore, when processing a reagent strip with a protective film, there is also S41 between S3 and S5, and the protective film on the surface of the material on the tray is punctured by the film opening mechanism. Specifically, the film opening cone 410 is driven to move to one of the reagent strips by the horizontal drive device 430, and then the film opening drive device 420 drives the film opening cone 410 to move downward to complete the film opening and then reset. During the film opening operation, the film opening action can be performed once after each reagent strip is moved to the tray, or the film opening action can be performed in batches after all the required reagent strips are transferred to the tray.

[0239] Furthermore, when processing a reagent strip with a protective cover, there is also an S42 between S3 and S5, in which the protective cover on the material is opened by the cover opening mechanism and the probe is removed from the material and placed on the tray by the probe transfer mechanism. Specifically, the horizontal drive device 430 drives the pressure rod 500 to move above all the reagent strips, and the downward pressure drive mechanism 600 drives the pressure rod 500 to move downward to press all the reagent strips on the tray 200, and then the horizontal moving mechanism 100 drives the first opening cover plate 801 and the second opening cover plate 803 to move to the ends of the protective covers of all the reagent strips on the tray, and then the fourth driving mechanism 90 drives the first opening cover plate 801 and the second opening cover plate 803 to move downward to abut against the ends of the protective cover, and then the fourth driving mechanism 90 and the horizontal moving mechanism 100 drive the first opening cover plate 801 and the second opening cover plate 803 to lift upward and translate toward the outside of the tray.

[0240] Next, the horizontal driving device 430 drives the probe clamp 60 to move above the probe above the reagent strip, and then, the third driving mechanism 70 drives the probe clamp 60 to move downward so that the first clamping block 604 and the second clamping block 607 are located on both sides of the probe, and then the second motor 601 drives the first clamping block 604 and the second clamping block 607 to close to clamp the probe, and the third driving mechanism 70 drives the probe clamp 60 to rise, and then the horizontal driving device 430 drives the probe clamp 60 to move the probe on it to the probe storage hole on the tray.

[0241] After the film opening and cover opening actions are completed, there is also S43 between S3 and S5, in which the pallet 200 is moved from the pallet fixing jig 300 to the pallet positioning jig h by the pallet transfer mechanism. Specifically, the pallet fixing jig releases the fixation of the pallet, the moving mechanism e drives the two clamping rods c1 of the pallet clamp c to move to both sides of the pallet, and then the pallet clamp c clamps the pallet, and then the moving mechanism e drives the pallet clamp c to move to the pallet positioning jig, and then the clamping rods c1 of the pallet clamp c release the pallet.

[0242] The automatic turntable g drives the tray fixing fixture 300 to rotate 90°, so that the reagent strip on the tray thereon switches from extending along the second horizontal direction X to extending along the first horizontal direction Y. At this time, it is convenient to synchronously add test liquid to the reagent strip through the two suction nozzle connecting tubes to improve efficiency.

[0243] The S3 includes, before sucking the test liquid, manually stacking a plurality of material boxes equipped with suction nozzles and placing them in the storage bin 01, closing the door 015, at this time, the conveying jig 03 is located in the first horizontal position, the two clamping arms 051 of the automatic unloading mechanism 05 are opened to allow the lowest material box on it to fall onto the conveying jig 03, and then the lifting drive device 058 drives the clamping arms to move upward and close at the same time, at this time, the two clamping arms 051 clamp a material box above the material box on the conveying jig 03 and lift all the material boxes on it to separate them from the material boxes on the conveying jig 03, at this time, the translation drive mechanism 034 drives the conveying jig 03 to be transported from the first horizontal position to the second horizontal position.

[0244] At this time, the moving mechanism 04 drives the suction nozzle connecting tube 02 to the second horizontal position of the material box on the conveying fixture 03 as needed to insert the suction nozzle thereon, and moves the suction nozzle outside the material box for suction and injection.

[0245] Before sucking different test liquids, unload the suction nozzle on the straw connecting nozzle through the discharger and move the suction nozzle connecting tube to the conveying fixture in the second horizontal position to replace the suction nozzle. Specifically, the moving mechanism 04 drives the suction nozzle connecting tube 02 to plug the suction nozzle 002 on it into the perforation 063 on the limiting plate 061 and make the top of the suction nozzle 002 located below the perforation, and then translates the suction nozzle connecting tube until the tube wall of the suction nozzle on it is located outside the perforation, preferably moved to the discharge hole 064. Subsequently, the moving mechanism 04 drives the suction nozzle connecting tube 02 to rise until its lower end moves above the limiting plate 061, completing the separation of the suction nozzle and the suction nozzle connecting tube. At this time, the moving mechanism 04 drives the suction nozzle connecting tube 02 to plug into the suction nozzle on the material box again and take it out to the outside for suction and injection.

[0246] When there are no more than 3 suction nozzles left in the material box 001 on the conveying jig 03 located at the second horizontal position; the moving mechanism 04 drives the suction nozzle connecting tube to be inserted into the suction nozzle or into a socket for inserting the suction nozzle; the translation drive mechanism drives the conveying jig to move from the second horizontal position to the first horizontal position, and the material box falls under the conveying jig under the action of gravity after the conveying jig moves to its outside. When the conveying jig returns to the first horizontal position, the automatic unloading mechanism automatically drops a material box onto the conveying jig. Then the translation drive mechanism drives the conveying jig 03 to move from the first horizontal position to the second horizontal position to supply suction nozzles again. After the suction nozzle is installed, the moving mechanism 04 drives the suction nozzle on the suction nozzle connecting tube 02 to move to the container filled with the corresponding test liquid, and then the suction injection mechanism 07 drives the syringe to absorb liquid, and the absorbed liquid does not enter the suction nozzle connecting tube 02. Then, the moving mechanism 04 drives the suction nozzle connecting tube to move until its end extends into the corresponding groove on the reagent strip and injects a certain amount of test liquid into the groove.

[0247] Further, after the addition of the test liquid is completed on the tray positioning fixture h, the automatic turntable g drives the tray fixing fixture 300 to rotate 90° in the opposite direction, so that the reagent strip on the tray thereon switches from extending along the first horizontal direction Y to extending along the second horizontal direction X, and then the moving mechanism e drives the tray clamp c to clamp the tray and move it into the testing device for testing. The specific test and the structure of the testing device are not limited here.

[0248] The method further includes S07, after the test is completed, the moving mechanism e drives the tray clamp c to move to the tray where the test is completed to clamp and move, the tray is flipped 180 degrees by the clamp flipping mechanism d, the moving mechanism e drives the tray to move below the blanking plate b, and the blanking plate b applies downward pressure to the top surface of the reagent strip in the tray 200 by lifting the tray 200 until the reagent strip falls from the limiting groove, after the blanking is completed, the tray transfer mechanism flips the tray 180 degrees again and places it on the tray fixing fixture 200. Repeat the above process.

[0249] There are many implementation methods of the present invention, and all technical solutions formed by equivalent transformation or equivalent transformation fall within the protection scope of the present invention.

Claims

1. A pre-test processing device, characterized in that: include The tray has at least one limiting groove; A pallet fixing jig has a structure for installing and fixing the pallet; A material supply mechanism, which has a structure for storing materials in batches and transferring the materials one by one onto a pallet; a test fluid storage mechanism having a set of containers; The injection mechanism has a structure that can extend into any of the containers to suck liquid and inject it into the groove of the material on the tray; the injection mechanism at least includes a vertical nozzle connecting tube, a suction injection mechanism connected to the upper end of the nozzle connecting tube, the nozzle connecting tube is connected to a mechanism that drives it to move horizontally along the first horizontal direction Y and / or the second horizontal direction X and along the vertical direction Z, and the suction injection mechanism moves horizontally synchronously with the nozzle connecting tube; The material supply mechanism includes Material storage device with multiple layers of openable and closable drawers; A multifunctional manipulator having an adsorption device for adsorbing the drawer and a first clamping mechanism for clamping materials in the drawer; A moving mechanism, driving the multifunctional manipulator to move; The multifunctional manipulator further comprises a code reader, which is tilted and has a lens facing downward and toward the material storage device; The pre-test processing device also includes The film opening mechanism comprises a row of film opening cones arranged along the extension direction of the limiting groove, the film opening cones are arranged vertically, and the row of film opening cones are connected to a mechanism for driving them to move vertically and horizontally synchronously; The cover opening mechanism at least comprises a first cover opening plate, the first cover opening plate is vertical and perpendicular to the limit groove, and the first cover opening plate is connected to a mechanism for driving the lifting and translation of the first cover opening plate; The probe transfer mechanism comprises a probe clamp and a mechanism for driving the probe clamp to rise, fall and translate. The probe transfer mechanism translates synchronously with the cover opening mechanism. A pallet positioning fixture having a limiting structure for positioning the pallet; The pallet transfer mechanism has a structure for moving the pallet between the pallet fixing jig and the pallet positioning jig; A blanking plate, which is vertically arranged and perpendicular or parallel to the limiting groove of the pallet on the pallet fixing jig; The tray transfer mechanism comprises The pallet clamp includes two clamping rods of equal height and extending horizontally and an opening and closing driving device for driving them to open and close, wherein the clamping rods are perpendicular or parallel to the blanking plate; A clamping jaw flipping mechanism, connected to the pallet clamping jaw and driving it to rotate around an axis parallel to the clamping rod; The moving mechanism drives the clamping jaw flipping mechanism to move in translation and lifting, and the clamping rod moves between the upper and lower positions of the blanking plate and moves from the outer side of the blanking plate to a position corresponding to the blanking plate in the vertical direction.

2. The pre-test processing device according to claim 1, characterized in that: The tray has at least 5 side-by-side limiting grooves.

3. The pre-test processing device according to claim 1, characterized in that: The suction injection mechanism comprises a syringe connected to the suction nozzle connecting tube and a mechanism for driving the piston rod of the syringe, and the suction nozzle is perpendicular to the syringe.

4. The pre-test processing device according to claim 1, characterized in that: The injection mechanism also includes a feeder and an automatic nozzle supply mechanism located next to it. The feeder includes a limit plate located within the moving range of the nozzle connecting tube and perpendicular to the nozzle connecting tube. At least one through hole is formed on the limit plate. When the nozzle connecting tube is coaxial with the through hole, its outer wall maintains a distance from the hole wall of the through hole.

5. The pre-test processing device according to claim 4, characterized in that: The automatic nozzle supply mechanism comprises The storage bin has a storage space for storing multiple layers of stacked objects, and its bottom is a discharge port; A conveying jig, which is located a certain distance below the storage bin and can move between a first horizontal position and a second horizontal position. At the first horizontal position, it corresponds to the unloading port of the storage bin; at the second horizontal position, it is located outside the storage bin; The automatic unloading mechanism can move the multi-layer stacked objects one by one to the conveying fixture at the first horizontal position.

6. The pre-test processing device according to claim 1, characterized in that: It comprises a horizontal pressure rod, the extension direction of which is perpendicular to the limiting groove and connected to a mechanism for driving the pressure rod to translate and lift, and the pressure rod can translate to just above the limiting groove.

7. The pre-test processing device according to claim 1, characterized in that: The lower end surface of the blanking plate is a group of planes with height differences.

8. Medical equipment, characterized in that: The invention comprises the pre-test processing device as described in any one of claims 1 to 7.

9. The detection method of the pre-test processing device according to any one of claims 1 to 7, characterized in that: At least the following steps are included: S1, the pallet is fixed on the pallet fixing fixture; S3, the material supply mechanism moves at least one material to a limiting groove of the tray for limiting; The S3 includes S31, the suction device on the multifunctional manipulator suctions the drawer and opens the drawer; S32, a barcode reader on the multifunctional robot reads the barcode on the material in the drawer to determine the type, quantity and location of the material; S33, the first clamping mechanism on the multifunctional manipulator clamps at least one material in the drawer and moves it out of the drawer and places it in the limiting groove of the tray; S5, the injection mechanism sucks liquid from the designated container and injects it into the groove of the material on the tray according to the metered amount; It also includes S41 located between S3 and S5, which punctures the protective film on the surface of the material on the pallet through a film opening mechanism; and / or The protective cover on the material is opened by the cover opening mechanism, and the probe is taken out from the material and placed on the tray by the probe transfer mechanism; and / or The pallet is moved from the pallet fixing fixture to the pallet positioning fixture through the pallet transfer mechanism.

10. The detection method according to claim 9, characterized in that: The S3 includes, before sucking different test liquids, unloading the suction nozzle on the suction tube connecting nozzle through the unloader and moving the suction nozzle connecting tube to the conveying fixture at the second horizontal position to replace the suction nozzle.

11. The detection method according to claim 9, characterized in that: Including S07, after the test is completed, the pallet is flipped 180 degrees by the pallet transfer mechanism and moved under the unloading plate. By lifting the pallet, the unloading plate applies downward pressure to the material in the pallet until the material falls from the limiting groove. After unloading is completed, the pallet transfer mechanism flips the pallet 180 degrees again and places it on the pallet fixing fixture.

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