Microfluidic chip, urine analysis method and device, toilet

Abstract

This invention provides a microfluidic chip, a urine analysis method and device, and a toilet, relating to the field of detection technology. The microfluidic chip includes: a chip body and an optical detection module fixed to the chip body; a reaction chamber is formed in the chip body, and multiple reagent channels are connected to the reaction chamber. The multiple reagent channels form corresponding reagent holes on the chip body. The reaction chamber is also connected to a urine channel, which forms a urine hole on the chip body. Each reagent hole is used to hold a reagent capsule. The reaction chamber is used for the urine flowing into the microfluidic chip to react with the detection reagent in the reagent capsule. The optical detection module is used to perform optical detection on the mixture of urine and detection reagent in the reaction chamber after receiving a detection command, thereby obtaining detection data. This invention provides a microfluidic chip with optical detection function, which can perform at least one optical detection on a user's urine.

Description

Technical Field

[0001] The present invention relates to the field of detection technology, and in particular to a microfluidic chip, a urine analysis method and device, and a toilet. Background Art

[0002] Urine testing is a routine examination item for medical institutions to examine patients. By analyzing the patient's urine, the concentration of chemical components in the urine can be obtained, such as glucose, urine protein, pH value, occult blood, nitrite, bilirubin, urobilinogen, red blood cells, white blood cells, etc. The concentration of chemical components in human urine has a normal range. When the patient has a lesion or changes in eating habits, the chemical composition of the urine will also change accordingly, so the patient's health status can be judged by the concentration of chemical components in the patient's urine.

[0003] At present, the changes in the concentration of chemical components in urine can reflect the patient's health status to a certain extent. It is of great significance if the patient's health status can be judged in advance by monitoring the patient's urine before the patient feels abnormal in the body. Summary of the invention

[0004] The purpose of the present invention is to provide a microfluidic chip, a urine analysis method and device, and a toilet. A microfluidic chip with an optical detection function is provided. The microfluidic chip can perform at least one optical detection on the user's urine, so that the user's urine can be analyzed on a daily basis, so that the user can view the urine analysis data and understand his or her own physical health status.

[0005] To achieve the above-mentioned purpose, the present invention provides a microfluidic chip, comprising: a chip body, an optical detection module fixed on the chip body; a reaction cavity and a plurality of reagent channels connected to the reaction cavity are formed in the chip body, the plurality of reagent channels form a corresponding plurality of reagent holes on the chip body, the reaction cavity is further connected to a urine channel, the urine channel forms a urine hole on the chip body, each of the reagent holes is used to install a reagent capsule; the reaction cavity is used for allowing urine flowing into the microfluidic chip through the urine channel to react with a detection reagent in the reagent capsule; the optical detection module is used to perform optical detection on a mixed liquid after the urine and the detection reagent react in the reaction cavity when receiving a detection instruction, so as to obtain detection data.

[0006] The present invention also provides a urine detection method, which is applied to the above-mentioned microfluidic chip, and the method comprises: when a detection instruction is received, the detection reagent in the reagent capsule installed on the reagent hole of the microfluidic chip flows into the reaction cavity through the corresponding reagent channel, and urine flows into the reaction cavity through the urine channel, and the detection reagent flowing into the reaction cavity reacts with the urine; the optical detection module performs optical detection on the mixed liquid after the reaction of urine and the detection reagent in the reaction cavity to obtain detection data.

[0007] The present invention also provides a urine analysis device, comprising the above-mentioned microfluidic chip, a plurality of reagent capsules and a processor, wherein the plurality of reagent capsules are respectively mounted on the reagent holes of the microfluidic chip, and the processor is connected to the optical detection module in the microfluidic chip; the processor is used to control the detection reagent in the reagent capsule to flow into the reaction chamber through the corresponding reagent channel when urine flows in, and to control urine to flow into the reaction chamber through the urine channel, and the detection reagent flowing into the reaction chamber reacts with urine; the processor is also used to use the optical detection module to perform optical detection on the mixed liquid after the reaction of urine and the detection reagent in the reaction chamber to obtain detection data; the processor is also used to receive multiple detection data returned by the microfluidic chip to obtain urine analysis data.

[0008] The present invention also provides a toilet, comprising the above-mentioned urine analysis device.

[0009] Compared with the prior art, the present invention provides a microfluidic chip with an optical detection function, the microfluidic chip comprising a chip body, an optical detection module fixed on the chip body, a reaction cavity and a plurality of reagent channels connected to the reaction cavity are formed in the chip body, the plurality of reagent channels form a corresponding plurality of reagent holes on the chip body, the reaction cavity is also connected to a urine channel, the urine channel forms a urine hole on the chip body, each reagent hole is used to install a reagent capsule, after urine and the detection reagent in the reagent capsule flow into the reaction cavity for chemical reaction, the optical detection module can perform optical detection on the mixed liquid after the reaction of urine and the detection reagent in the reaction cavity based on the received detection instruction, and obtain detection data, that is, the microfluidic chip can perform at least one optical detection on the user's urine, so that the user's urine can be analyzed on a daily basis, so that the user can view the analysis data of the urine and understand his own physical health status.

[0010] In one embodiment, the chip body includes an upper plate and a lower plate fixed to each other, the reaction chamber, the urine channel and the reagent channel are formed between the upper plate and the lower plate, and the reagent hole and the urine hole are both formed on the upper surface of the upper plate.

[0011] In one embodiment, the optical detection module includes: a light source and a chromatographic sensor; the light source is fixed on the upper plate at a position corresponding to the reaction cavity, and the chromatographic sensor is fixed on the lower plate at a position corresponding to the reaction cavity; when optically detecting the mixed liquid in the reaction cavity, the light source emits a test light toward the reaction cavity, and the test light passes through the mixed liquid in the reaction cavity and then irradiates the chromatographic sensor.

[0012] In one embodiment, the reaction chamber forms a plurality of light-transmitting upper detection points on the upper plate, and the reaction chamber forms a plurality of light-transmitting lower detection points on the lower plate, and the upper detection points correspond to the lower detection points one by one; the test light emitted by the light source toward the reaction chamber passes through the upper detection points, the mixed liquid in the reaction chamber, and the lower detection points to irradiate the chromatographic sensor.

[0013] In one embodiment, a cleaning inlet channel and a cleaning outlet channel connected to the reaction chamber are respectively formed in the chip body, the cleaning inlet channel forms a cleaning inlet on the chip body, and the cleaning outlet channel forms a cleaning outlet on the chip body; the cleaning inlet channel is used for cleaning the reaction chamber with the cleaning liquid flowing in from the cleaning inlet; the cleaning outlet channel is used for the cleaning liquid in the reaction chamber to flow out from the cleaning outlet.

[0014] In one embodiment, an air channel connected to the reaction chamber is also formed in the chip body, and the air channel forms an air inlet on the chip body; the air channel is used to supply air to enter the reaction chamber from the air inlet after the reaction chamber is cleaned, so as to discharge the liquid in the reaction chamber.

[0015] In one embodiment, multiple reagent wells share one reagent channel. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 is a schematic diagram of a urine analysis device and a toilet applied to the microfluidic chip in the first embodiment of the present invention;

[0017] Figure 2 is a schematic structural diagram of a microfluidic chip according to a first embodiment of the present invention;

[0018] Figure 3 is a schematic structural diagram of an upper plate of a chip body of a microfluidic chip according to a first embodiment of the present invention;

[0019] Figure 4 is a schematic structural diagram of a lower plate of a chip body of a microfluidic chip according to a first embodiment of the present invention;

[0020] Figure 5 is a schematic structural diagram of an upper plate of a chip body of a microfluidic chip according to a second embodiment of the present invention;

[0021] Figure 6 and Figure 7 is a schematic structural diagram of a urine analysis device applied to the microfluidic chip in the second embodiment of the present invention;

[0022] Figure 8 is a specific flow chart of the urine detection method according to the third embodiment of the present invention;

[0023] Fig. 9 is a schematic diagram of a toilet according to a fourth embodiment of the present invention;

[0024] Fig.10 Schematic diagram of a urine analysis device in a toilet according to a fourth embodiment of the present invention. Specific embodiments

[0025] The following will be described in detail with reference to the accompanying drawings to provide a clearer understanding of the purpose, features and advantages of the present invention. It should be understood that the embodiments shown in the accompanying drawings are not intended to limit the scope of the present invention, but are only intended to illustrate the essential spirit of the technical solution of the present invention.

[0026] In the following description, certain specific details are set forth for the purpose of illustrating various disclosed embodiments to provide a thorough understanding of the various disclosed embodiments. However, those skilled in the relevant art will recognize that the embodiments may be practiced without one or more of these specific details. In other cases, well-known devices, structures, and techniques associated with the present application may not be shown or described in detail to avoid unnecessarily obscuring the description of the embodiments.

[0027] Unless the context requires otherwise, throughout the specification and claims, the word "comprise" and variations such as "include" and "have" should be construed in an open, inclusive sense, ie, should be interpreted as "including, but not limited to."

[0028] References throughout the specification to "one embodiment" or "an embodiment" indicate that a particular feature, structure, or characteristic described in connection with the embodiment is included in at least one embodiment. Thus, the appearances of "in one embodiment" or "in an embodiment" in various places throughout the specification are not necessarily all referring to the same embodiment. Furthermore, the particular features, structures, or characteristics may be combined in any manner in one or more embodiments.

[0029] As used in this specification and the appended claims, the singular forms "a," "an," and "" include plural referents unless the context clearly dictates otherwise. It should be noted that the term "or" is generally employed in its sense including "and / or" unless the context clearly dictates otherwise.

[0030] In the following description, in order to clearly show the structure and working mode of the present invention, many directional words will be used for description, but the words "front", "back", "left", "right", "outside", "inside", "outward", "inward", "up", "down", etc. should be understood as convenient terms and should not be understood as restrictive terms.

[0031] The first embodiment of the present invention relates to a microfluidic chip for optical detection of urine, such as Figure 1 As shown, the microfluidic chip can be arranged in a urine analysis device 10, and the urine analysis device 10 is assembled in a toilet 20. For example, the urine analysis device 10 is fixed to the inner wall of the toilet 20 by bonding. An opening 11 is formed on the shell of the urine analysis device 10 so that each time the user uses the toilet, the urine analysis device 10 can collect the user's urine through the opening 11 and input it into the microfluidic chip, and the microfluidic chip then performs optical detection on the urine.

[0032] The microfluidic chip comprises a chip body and an optical detection module fixed on the chip body.

[0033] A reaction cavity and a plurality of detection reagent channels connected to the reaction cavity are formed in the chip body. The plurality of reagent channels form a corresponding plurality of reagent holes on the chip body. The reaction cavity is also connected to a urine channel, which forms a urine hole on the chip body. Each reagent hole is used to install a reagent capsule.

[0034] The reaction chamber is used for the urine flowing into the microfluidic chip through the urine channel to react with the detection reagent in the reagent capsule.

[0035] The optical detection module is used to perform optical detection on the mixed liquid after the urine in the reaction chamber reacts with the detection reagent to obtain detection data.

[0036] Combine the following Figures 2 to 4 The specific structure diagram of the microfluidic chip is described in detail.

[0037] The chip body includes an upper plate 101 and a lower plate 102 fixed to each other, a reaction chamber 103, a urine channel 104 and a reagent channel 105 are formed between the upper plate 101 and the lower plate 102, reagent holes 106 and urine holes 107 are formed on the upper surface of the upper plate 101, and a reagent capsule 3 is installed in each reagent hole 106. Among them, a channel fence 1012 is set between the upper plate 101 and the lower plate 102, and the channel fence 1012 forms a plurality of channels for liquid supply in the chip body; the urine channel 104 and the reagent channel 105 share a part of the channel in the chip body.

[0038] The optical detection module includes: a light source 21 and a chromatographic sensor 22. The light source 21 is fixed on the upper plate 101 at a position corresponding to the reaction chamber 103, and the chromatographic sensor 22 is fixed on the lower plate 102 at a position corresponding to the reaction chamber 103. The light source 21 can be a laser, a light emitting diode, a halogen tungsten lamp, etc. The chromatographic sensor 22 includes a light detector and a wavelength selector. The light detector can convert the optical signal into an electrical signal, such as a photomultiplier tube, a photodiode, a CMOS sensor, etc.; the wavelength selector is used to select the wavelength of the incident light, and the wavelength selector is, for example, a grating, a triangular prism or a filter.

[0039] When optical detection is performed on the mixed liquid in the reaction chamber 103 , the light source 21 emits a test light toward the reaction chamber 103 , and the test light passes through the mixed liquid in the reaction chamber 103 and then irradiates the chromatographic sensor 22 .

[0040] In one example, the reaction chamber 103 forms a plurality of light-transmitting upper detection points 1031 on the upper plate 101, and the reaction chamber 103 forms a plurality of light-transmitting lower detection points 1032 on the lower plate 102, and the upper detection points 1031 correspond to the lower detection points 1032 one by one. Figure 3 and Figure 4 As shown, the number of upper detection points 1031 and lower detection points 1032 is three for example. The test light emitted by the light source 21 toward the reaction chamber 103 passes through the upper detection point 1031 , the mixed liquid in the reaction chamber 103 and the lower detection point 1032 to irradiate the chromatographic sensor 22 .

[0041] When the user uses the toilet, urine flows in through the opening 11 of the urine analysis device. A processor is provided in the urine molecule device, and the processor is connected to the optical detection module of the microfluidic chip; the processor can control the urine to flow into the reaction cavity 103 of the microfluidic chip, and at the same time, the processor will control the detection reagent in the reagent capsule 3 to flow into the reaction cavity 103 of the microfluidic chip, and the urine flowing into the reaction cavity 103 of the microfluidic chip reacts chemically with the detection reagent, and the processor then sends a detection instruction to the optical detection module of the microfluidic chip. After receiving the detection instruction, the light source 21 in the optical detection module sends a test light (generally diffuse light) of a preset wavelength toward the reaction cavity 103, and the test light is shot into the reaction cavity 103 through each upper detection point 1031, and Reflection occurs in the mixed liquid in the reaction chamber 103, and the reflected light is irradiated onto the spectral sensor 22 through the lower detection point 1032. The wavelength selection in the spectral sensor 22 first selects light of a set wavelength from the incident light, and then converts the light of the set wavelength into an electrical signal, which is the detection data. After generating the detection data, the spectral sensor 22 sends the detection data to the processor. In a urine analysis, multiple tests need to be performed on the urine. At this time, multiple reagent capsules installed on the microfluidic chip contain multiple detection reagents, and the multiple detection reagents react with the urine in the reaction chamber respectively. The optical detection module also performs multiple optical detections on the urine to obtain multiple detection data, so that the processor can generate urine analysis results based on these multiple detection data for the user to view.

[0042] Compared with the prior art, the present embodiment provides a microfluidic chip with an optical detection function, the microfluidic chip comprising a chip body, an optical detection module fixed on the chip body, a reaction cavity and a plurality of reagent channels connected to the reaction cavity are formed in the chip body, the plurality of reagent channels form a corresponding plurality of reagent holes on the chip body, the reaction cavity is further connected to a urine channel, the urine channel forms a urine hole on the chip body, each reagent hole is used to install a reagent capsule, after urine and the detection reagent in the reagent capsule flow into the reaction cavity for chemical reaction, the optical detection module can perform optical detection on the mixed liquid after the reaction of urine and the detection reagent in the reaction cavity based on the received detection instruction to obtain detection data, that is, the microfluidic chip can perform at least one optical detection on the user's urine, so that the user's urine can be analyzed on a daily basis, so that the user can view the analysis data of the urine and understand his or her own physical health status.

[0043] The second embodiment of the present invention relates to a microfluidic chip. The main difference between this embodiment and the first embodiment is that: Figure 5A cleaning inlet channel and a cleaning outlet channel connected to the reaction chamber 103 are respectively formed in the chip body. The cleaning inlet channel forms a cleaning inlet 108 on the upper surface of the upper plate 101 of the chip body, and the cleaning outlet channel forms a cleaning outlet 109 on the upper surface of the upper plate 101 of the chip body.

[0044] The cleaning inlet channel is used for cleaning the reaction chamber 103 with the cleaning liquid flowing in from the cleaning inlet 108 .

[0045] The cleaning outlet channel 109 is used for allowing the cleaning liquid in the reaction chamber 103 to flow out from the cleaning outlet 109 .

[0046] In one example, an air channel connected to the reaction chamber is further formed in the chip body, and the air channel forms an air inlet 110 on the upper surface of the upper plate 101 of the chip body.

[0047] The air channel 112 is used to supply air from the air inlet 110 to enter the reaction chamber 103 after the reaction chamber 103 is cleaned, so as to discharge the liquid in the reaction chamber 103 .

[0048] In one example, a cleaning liquid connection channel and a waste liquid channel are also formed in the chip body of the microfluidic chip. The cleaning liquid connection channel forms a cleaning liquid interface 111 on the upper surface of the upper plate 101 of the chip body, and the waste liquid channel forms a waste liquid outlet 112 on the upper surface of the upper plate 101 of the chip body. In addition, a vent channel is also formed in the chip body of the microfluidic chip, and the vent channel 118 forms a vent port 113 on the upper surface of the upper plate 101 of the chip body.

[0049] Combine the following Figure 6 and Figure 7 The urine analysis device of the microfluidic chip application shown is described in detail.

[0050] In this embodiment, the cleaning inlet 108 and the cleaning outlet are connected to a cleaning pump (for example, a diaphragm pump) in the urine analysis device, the cleaning liquid interface 111 is connected to a cleaning liquid storage device for storing cleaning liquid in the urine analysis device, and the waste liquid outlet 112 is connected to one end of a peristaltic pump in the urine analysis device, and the other end of the peristaltic pump is connected to the waste liquid storage device in the urine analyzer.

[0051] The reagent hole 106, urine hole 107, waste liquid outlet 112, cleaning liquid connection port 111, cleaning inlet 108, cleaning outlet 109, air inlet 110 and air vent 113 on the microfluidic chip are all opened or closed by corresponding valves 4. Figure 6 and Figure 7As shown, the microfluidic chip also includes a plurality of valves 4, and mounting holes corresponding to the openings or openings are provided on the lower plate 102, and each valve 4 is respectively installed on each mounting hole on the lower plate 102, and the valve 4 is used to control the opening or closing of each opening or opening on the upper plate 101. In this embodiment, each valve 4 can be installed on a circuit board 5 having a control circuit, that is, the microfluidic chip also includes a circuit board 5, and the circuit board 5 is fixed to the lower plate 102, and the fixing method can be fixed by screws; the processor 6 in the urine analysis device is installed on the circuit board 7, and the circuit board 5 is fixed and electrically connected to the circuit board 7, so that the processor 6 can control the opening or closing of each valve 4. It should be noted that the circuit board 5 and the circuit board 7 in this embodiment also include peripheral circuits, interfaces and other components, which will not be repeated here. In addition, the urine analysis device also includes a shell, and the shell includes an upper shell 81 and a lower shell 82, and the opening 11 is formed on the upper shell 81.

[0052] When the user uses the toilet, the user's urine flows into the urine analysis device through the opening 11 on the upper shell 81 of the urine analysis device, and the processor 6 inputs the urine into the microfluidic chip multiple times based on the items to be detected. When each item of urine is detected, the corresponding detection reagent is allowed to flow into the reaction chamber 103 of the microfluidic chip by controlling the valve to open, so that the urine flowing into the reaction chamber 103 can react chemically with the detection reagent.

[0053] Specifically, when no urine enters the urine analysis device, except for the valve 4 corresponding to the air vent 113 on the microfluidic chip, which is in an open state, the other valves 4 are in a closed state. When urine enters the urine storage device in the urine analysis device through the opening 11 on the shell, the processor 6 controls the valve 4 corresponding to the air vent 113 to close, and controls the valve 4 corresponding to the urine hole 107 to open, controls the peristaltic pump to pump out a first preset proportion of urine from the urine storage device to the reaction chamber 103, and then closes the valve 4 corresponding to the urine hole 107, and then controls the valve 4 corresponding to the reagent capsule 3 of the current detection item to open, and controls the peristaltic pump to pump out a second preset proportion of detection reagent from the reagent capsule 3 to the reaction chamber 103, and then closes the valve 4 corresponding to the reagent capsule 3; at this time, the detection reagent reacts with the urine in the reaction chamber 103, and the processor 6 controls the optical detection module in the microfluidic chip to pump the urine into the reaction chamber. The mixed liquid after the urine in the body 103 reacts with the detection reagent is optically detected, and the optical detection module sends the detection data obtained by the optical detection to the processor 6. The processor 6 determines that the current detection project is completed, and first controls the peristaltic pump to pump out the mixed liquid after the reaction from the reaction chamber 103 to the waste liquid storage; then, controls to open the valve 4 of the cleaning liquid connection port 111 and the cleaning inlet 108, and controls the cleaning pump to pump out the cleaning liquid from the cleaning liquid storage to clean the reaction chamber 103 of the microfluidic chip, and then closes the cleaning liquid connection port 111 and the valve 4 of the cleaning inlet 108; then opens the valve 4 of the cleaning outlet 109, controls the cleaning pump to pump out the cleaning liquid in the reaction chamber 103, and then closes the valve 4 of the cleaning outlet 109, and then opens the valve 4 corresponding to the air inlet 27, and the cleaning pump pumps air to discharge and dry the liquid in the reaction chamber 103, and then closes the valve 4 corresponding to the air inlet 27. Then the processor 6 performs the detection of the next detection item, controls the valve 4 corresponding to the urine hole 107 to open, controls the peristaltic pump to pump out the first preset proportion of urine from the urine storage device to the reaction chamber 103, and then closes the valve 4 corresponding to the urine hole 107, and then controls the valve 4 corresponding to the reagent capsule 3 of the next detection item to open, and controls the peristaltic pump to pump out the second preset proportion of detection reagent from the reagent capsule 3 to the reaction chamber 103, and then closes the valve 4 corresponding to the reagent capsule 3, and repeats the above process to complete the optical detection. After each detection item is completed, the reaction chamber 103 is cleaned, and then the next detection item is detected after cleaning, until all detection items are completed, and the processor 6 summarizes the detection data of multiple detection items in this urine detection, and then obtains the urine analysis data of this urine detection based on these multiple detection data.

[0054] In this embodiment, the types of detection reagents in the multiple reagent capsules correspond one-to-one to the multiple second preset ratios, that is, based on different detection items, the amount of detection reagents required each time is different. Therefore, the processor 6 controls the peristaltic pump to pump different reagents from different reagent capsules 3 into the reaction chamber 103 in different ratios, so as to avoid the amount of detection reagents affecting the detection data of optical detection, thereby ensuring the accuracy of urine analysis to a certain extent.

[0055] The third embodiment of the present invention relates to a urine detection method, which is applied to the microfluidic chip in the first or second embodiment.

[0056] Please refer to Figure 8 , is a specific flow chart of the urine detection method of this embodiment.

[0057] Step 101, when a detection instruction is received, the detection reagent in the reagent capsule installed on the reagent hole of the microfluidic chip flows into the reaction chamber through the corresponding reagent channel, and urine flows into the reaction chamber through the urine channel, and the detection reagent flowing into the reaction chamber reacts with the urine.

[0058] Step 102: The optical detection module performs optical detection on the mixed liquid after the urine and the detection reagent in the reaction chamber to obtain detection data.

[0059] Specifically, when the user uses the toilet, urine flows in through the opening 11 of the urine analysis device. A processor is provided in the urine molecule device, and the processor is connected to the optical detection module of the microfluidic chip; the processor can control the urine to flow into the reaction cavity 103 of the microfluidic chip, and at the same time, the processor will also control the detection reagent in the reagent capsule 3 to flow into the reaction cavity 103 of the microfluidic chip. The urine flowing into the reaction cavity 103 of the microfluidic chip reacts chemically with the detection reagent, and the processor then sends a detection instruction to the optical detection module of the microfluidic chip. After receiving the detection instruction, the light source 21 in the optical detection module sends a test light of a preset wavelength (generally diffuse light) toward the reaction cavity 103, and the test light is shot into the reaction cavity 103 through each upper detection point 1031. , and is reflected in the mixed liquid in the reaction chamber 103. The reflected light is irradiated onto the spectral sensor 22 through the lower detection point 1032. The wavelength selection in the spectral sensor 22 first selects light of a set wavelength from the incident light, and then converts the light of the set wavelength into an electrical signal, which is the detection data. After generating the detection data, the spectral sensor 22 sends the detection data to the processor; in a urine analysis, multiple tests need to be performed on the urine. At this time, multiple reagent capsules installed on the microfluidic chip contain multiple detection reagents, and the multiple detection reagents react with the urine in the reaction chamber respectively. The optical detection module also performs multiple optical detections on the urine to obtain multiple detection data, so that the processor can generate urine analysis results based on these multiple detection data for the user to view.

[0060] Compared with the prior art, the present embodiment provides a microfluidic chip with an optical detection function, the microfluidic chip comprising a chip body, an optical detection module fixed on the chip body, a reaction cavity and a plurality of reagent channels connected to the reaction cavity are formed in the chip body, the plurality of reagent channels form a corresponding plurality of reagent holes on the chip body, the reaction cavity is further connected to a urine channel, the urine channel forms a urine hole on the chip body, each reagent hole is used to install a reagent capsule, after urine and the detection reagent in the reagent capsule flow into the reaction cavity for chemical reaction, the optical detection module can perform optical detection on the mixed liquid after the reaction of urine and the detection reagent in the reaction cavity based on the received detection instruction to obtain detection data, that is, the microfluidic chip can perform at least one optical detection on the user's urine, so that the user's urine can be analyzed on a daily basis, so that the user can view the analysis data of the urine and understand his or her own physical health status.

[0061] A fourth embodiment of the present invention relates to a urine analysis device for testing a user's urine, such as Figure 1As shown, the urine analysis device 10 is assembled in the toilet 20. For example, the urine analysis device 10 is fixed to the inner wall of the toilet 20 by bonding, so that the user's urine can be collected for testing every time the user uses the toilet.

[0062] Please refer to Figure 6 and Figure 7 The urine analysis device includes the microfluidic chip of the first embodiment or the second embodiment, a plurality of reagent capsules 3 and a processor 6. In addition, the urine analysis device also includes a housing, which includes an upper housing 81 and a lower housing 82, and an opening 11 is formed on the upper housing 81.

[0063] The processor 6 is used to control the detection reagent in the reagent capsule 3 to flow into the reaction chamber 103 through the corresponding reagent channel when urine flows in, and to control urine to flow into the reaction chamber 103 through the urine channel, so that the detection reagent flowing into the reaction chamber 103 reacts with the urine.

[0064] The processor 6 is further used to use the optical detection module to perform optical detection on the mixed liquid after the urine and the detection reagent in the reaction chamber 103 to obtain detection data.

[0065] The processor 6 is also used to receive a plurality of detection data returned by the microfluidic chip to obtain urine analysis data.

[0066] In one example, the urine analysis device is also provided with a wireless communication module (not shown in the figure, the wireless communication module can be installed on the circuit board 7), such as WIFI, 4G, 5G, etc., so that the processor 6 can be connected to the cloud server by wireless, and the urine analysis data obtained from each urine test is sent to the cloud server, and the cloud server monitors the urine analysis data of the user for a long period of time, such as 7 days, 15 days, 30 days, etc. In addition, the user can also connect electronic devices such as mobile phones and computers to the urine analysis device, so that the processor 6 can also send the urine analysis data to the user's electronic device, so that the user can view his own urine analysis data in real time and view his own physical condition through the urine analysis data.

[0067] In this embodiment, different types of detection reagents can be respectively contained in multiple reagent capsules, and the types of detection reagents can be set according to the detection items of urine. For example, the detection reagents used for urine creatinine detection are creatinine colorimetric solution and creatinine analysis buffer solution; the detection reagent used for urine protein detection is sulfosalicylic acid solution; the detection reagent used for urine pH detection is bromothymol blue solution; the detection reagent used for urine ketone body detection is 10% concentration of ferric chloride; the detection reagent used for vitamin C detection is acid buffer solution, phenanthroline colorimetric solution and VC analysis buffer solution; the detection reagent used for urine nitrite detection is Griess solution; It should be noted that the above only lists some of the detection items and the required detection reagents, and the detection items can be increased or decreased as needed, such as adding the detection of urine albumin and urine hemoglobin.

[0068] It should be noted that the urine analysis device in this embodiment may also include a battery holder (not shown in the figure), which is connected to the circuit board 202. When the battery is installed in the battery holder, the battery can power the processor 6 in the urine analysis device and the optical detection module 204, valve 201, etc. in the microfluidic chip. In addition, the urine analysis device in this embodiment may also include a residual sensor for detecting the residual amount of the detection reagent in each reagent capsule, and each residual sensor is connected to the processor 6, so that the processor 6 can issue a prompt in time when the residual amount of the detection reagent in any reagent capsule is insufficient. The reminder method is, for example, sending a prompt message through a cloud server or directly to the electronic device of the connected user.

[0069] For an example, see Fig. 9 The urine analysis device further includes: a power supply receiving module 901 and a power supply 902, and the power supply receiving module 901 is connected to the processor 6 and the microfluidic chip respectively.

[0070] The urine analysis device 10 is mounted on the inner wall of the toilet 20, and the power receiving module 901 is fixed in a preset area inside the shell, that is, the power receiving module 901 is mounted in a preset area on the lower shell 31 of the shell, and the preset area is located in the area of ​​the lower shell 82 of the shell close to the inner wall of the toilet 20; the power supply 902 is mounted on the outer wall of the toilet 20, and the power supply 902 corresponds to the position of the power receiving module 901. The power supply 902 can be fixed to the toilet 20 by adhesion.

[0071] The power supply 902 is used to provide power to the power receiving module 901 .

[0072] The power receiving module 901 is used to use the received electric energy to power the processor 6 and the microfluidic chip respectively.

[0073] Please refer to Fig.10In this example, electromagnetic induction can be used for wireless power supply. The power supply receiving module 901 includes a charging chip 9011 and a wireless receiving coil 9012. The charging chip 9011 is arranged on the circuit board 7. The wireless receiving coil 9012 is fixed on the shell 82 and is located inside the urine analysis device. The wireless receiving coil 9012 is connected to the circuit board 7 of the urine analysis device 10. The wireless receiving coil 9012 is connected to the charging chip 9011 through the wiring on the circuit board 7. The power supply 102 is provided with a wireless transmitting coil and a battery pack (not shown in the figure). The battery pack is connected to the wireless transmitting coil. The wireless transmitting coil converts the electric energy of the battery pack into a magnetic field. The wireless receiving coil 9012 induces an alternating current due to the existence of the alternating magnetic field. Then, the wireless charging chip 9011 on the circuit board 7 converts the alternating current into direct current to power the processor 6 and the microfluidic chip respectively.

[0074] It should be noted that Fig.10 The positions of the charging chip 9011 and the wireless receiving coil 9012 are only schematically described, but are not limited to this. A power supply circuit board for fixing the charging chip 9011 may also be provided. The wireless receiving coil 9012 is fixed on the shell 82 and located inside the urine analysis device. The wireless receiving coil 1012 is connected to the charging chip 9011 through the power supply circuit board.

[0075] In this embodiment, the power supply 902 uses the power receiving module 901 to wirelessly power the urine analysis device 10, so that the user can maintain the power supply of the urine analysis device 10 by charging the power supply 902, which is more convenient and quick, and easy for the user to operate. Among them, the battery pack in the power supply 902 can be a rechargeable battery pack. In this case, a charging interface is provided on the power supply 902, and the power supply 902 can be connected to an external power supply through a charging cable, and the external power supply charges the rechargeable battery pack.

[0076] In this embodiment, the types of detection reagents in multiple reagent capsules correspond one-to-one to multiple second preset ratios, that is, based on different detection items, the amount of detection reagents required each time is different. Therefore, the processor 6 controls the peristaltic pump to pump different ratios of reagents from different reagent capsules into the reaction chamber, so as to avoid the amount of detection reagents affecting the detection data of optical detection, thereby ensuring the accuracy of urine analysis to a certain extent.

[0077] In one example, a temperature sensor (not shown in the figure) is also provided in the urine analysis device. The temperature sensor is provided at the opening 11 or at a position near the opening 11 in the housing, and is connected to the circuit board 7, so that the processor 6 is electrically connected to the temperature sensor through the circuit board 7. When no user uses the toilet 20, the temperature detected by the temperature sensor is the indoor temperature, and the indoor temperature value is sent to the processor 6; when a user uses the toilet 20, urine flows into the urine analysis device from the opening 11, and the temperature sensor detects the user's urine temperature value, and sends the detected urine temperature value to the processor 6. The urine temperature value is greater than the indoor temperature. The processor 6 determines that the detected temperature value increases, and the difference between the urine temperature value and the indoor temperature value is greater than or equal to the preset first temperature threshold, and determines that urine is detected to flow into the urine analysis device. The processor 6 controls the urine analysis device to enter the detection state and wakes up the microfluidic chip to perform urine detection. Among them, the first temperature threshold is, for example, 2 degrees, 5 degrees, 10 degrees, etc.

[0078] In one example, the processor 6 is also used to control the urine analysis device to enter a standby state after receiving multiple detection data returned by the microfluidic chip and obtaining urine analysis data, if the temperature value sent by the temperature sensor is lowered and the temperature reduction value is greater than or equal to a preset second temperature threshold. Specifically, when the urine test is completed, if the user flushes at this time, the temperature sensor detects the water temperature value and sends it to the processor 6. The water temperature value sent by the temperature sensor received by the processor 6 is less than the urine temperature value. It is determined that the temperature has dropped and the temperature reduction value is greater than or equal to the preset second temperature threshold, indicating that the user has finished using the toilet. The urine analysis device is controlled to enter a standby state again, thereby reducing the power consumption of the urine analysis device. The second temperature threshold is, for example, 2 degrees, 5 degrees, 10 degrees, etc.

[0079] In one example, the processor 6 is also used to adjust the first temperature threshold and the second temperature threshold according to the currently detected temperature value when the temperature value sent by the temperature sensor remains unchanged within a preset time. Specifically, when the user has not used the toilet for a long time, the temperature detected by the temperature sensor at this time is the indoor temperature at this time. Since the indoor temperature changes with the seasons, and the human urine temperature is basically maintained constant, the first temperature threshold and the second temperature threshold can be adjusted in real time according to the indoor temperature value. For example, in summer, the indoor temperature is higher, and the temperature difference between the indoor temperature and the urine temperature is reduced, and the first temperature threshold and the second temperature threshold can be appropriately reduced; in winter, the indoor temperature is lower, and the temperature difference between the indoor temperature and the urine temperature is increased, and the first temperature threshold and the second temperature threshold can be appropriately increased.

[0080] The urine analysis device in this embodiment can analyze the correlation data between the user's metabolism and the user's daily behavior state based on the urine analysis data collected continuously and for a long time. For example, the user's eating habits (including meals, nutrition, vitamins, tobacco and alcohol, etc.), disease conditions, work and rest rules, exercise habits, sleep status or medication status and other behavioral states will all be presented in the user's urine. When certain behavioral states of the user change, it will have a corresponding impact on the user's urine. The urine analysis device can also detect the changes in urine, and then the urine analysis device can analyze the correlation between the user's metabolism and the user's behavior state based on long-term and continuous urine analysis data.

[0081] Since the first to third embodiments correspond to this embodiment, this embodiment can be implemented in conjunction with the first to third embodiments. The relevant technical details mentioned in the first to third embodiments are still valid in this embodiment, and the technical effects that can be achieved in the first to third embodiments can also be achieved in this embodiment. In order to reduce repetition, they are not repeated here. Accordingly, the relevant technical details mentioned in this embodiment can also be applied in the first to third embodiments.

[0082] The fifth embodiment of the present invention relates to a toilet, comprising the urine analysis device of the fourth embodiment of claim 1. Figure 1 The urine analysis device 10 is assembled in the toilet 20. For example, the urine analysis device 10 is fixed to the inner wall of the toilet 20 by bonding, so that the user's urine can be collected for detection every time the user uses the toilet.

[0083] Since the first to fourth embodiments correspond to this embodiment, this embodiment can be implemented in conjunction with the first to fourth embodiments. The relevant technical details mentioned in the first to fourth embodiments are still valid in this embodiment, and the technical effects that can be achieved in the first to fourth embodiments can also be achieved in this embodiment. In order to reduce repetition, they will not be repeated here.

[0084] Preferred embodiments of the present invention have been described above in detail, but it should be understood that aspects of the embodiments can be modified, if necessary, to employ aspects, features and concepts of the various patents, applications and publications to provide further embodiments.

[0085] These and other changes can be made to the embodiments in light of the above detailed description.In general, in the claims, the terms used should not be considered limited to the specific embodiments disclosed in the specification and the claims, but should be construed to include all possible embodiments along with the full scope of equivalents to which these claims are entitled.

Claims

1. A microfluidic chip, characterized in that: Applied to a urine analysis device, the urine analysis device comprises a housing, the housing comprises an upper housing and a lower housing, an opening is formed on the upper housing; the microfluidic chip comprises: a chip body, an optical detection module fixed on the chip body; The chip body is formed with a reaction cavity and a plurality of reagent channels connected to the reaction cavity, the plurality of reagent channels form a corresponding plurality of reagent holes on the chip body, the reaction cavity is further connected with a urine channel, the urine channel forms a urine hole on the chip body, and each of the reagent holes is used to install a reagent capsule; The reaction chamber is used for the urine flowing into the microfluidic chip through the urine channel to react with the detection reagent in the reagent capsule; The optical detection module is used to perform optical detection on the mixed liquid after the urine and the detection reagent react in the reaction chamber to obtain detection data when receiving the detection instruction; The chip body comprises an upper plate and a lower plate fixed to each other, the reaction chamber, the urine channel and the reagent channel are formed between the upper plate and the lower plate, and the reagent hole and the urine hole are both formed on the upper surface of the upper plate; The optical detection module comprises: a light source and a chromatographic sensor; the light source is fixed on a position on the upper plate corresponding to the reaction chamber, and the chromatographic sensor is fixed on a position on the lower plate corresponding to the reaction chamber; When optical detection is performed on the mixed liquid in the reaction chamber, the light source emits a test light toward the reaction chamber, and the test light passes through the mixed liquid in the reaction chamber and then irradiates the chromatographic sensor; The reaction chamber forms a plurality of light-transmitting upper detection points on the upper plate, and the reaction chamber forms a plurality of light-transmitting lower detection points on the lower plate, and the upper detection points correspond to the lower detection points one by one; The test light emitted by the light source toward the reaction chamber passes through the upper detection point, the mixed liquid in the reaction chamber, and the lower detection point to irradiate the chromatographic sensor.

2. The microfluidic chip according to claim 1, characterized in that: The chip body is also formed with a cleaning inlet channel and a cleaning outlet channel connected to the reaction chamber, the cleaning inlet channel forms a cleaning inlet on the chip body, and the cleaning outlet channel forms a cleaning outlet on the chip body; The cleaning inlet channel is used for cleaning the reaction chamber with the cleaning liquid flowing in from the cleaning inlet; The cleaning outlet channel is used for allowing the cleaning liquid in the reaction chamber to flow out from the cleaning outlet.

3. The microfluidic chip according to claim 2, characterized in that: An air channel connected to the reaction chamber is also formed in the chip body, and the air channel forms an air inlet on the chip body; The air channel is used to supply air to enter the reaction chamber from the air inlet after the reaction chamber is cleaned, so as to discharge the liquid in the reaction chamber.

4. A urine detection method, characterized in that: The microfluidic chip applied to any one of claims 1 to 3, the method comprising: When a detection instruction is received, the detection reagent in the reagent capsule installed on the reagent hole of the microfluidic chip flows into the reaction chamber through the corresponding reagent channel, and the urine flows into the reaction chamber through the urine channel, and the detection reagent flowing into the reaction chamber reacts with the urine; The optical detection module performs optical detection on the mixed liquid after the urine and the detection reagent react in the reaction chamber to obtain detection data.

5. The urine detection method according to claim 4, characterized in that: The microfluidic chip is the microfluidic chip in claim 3; controlling the optical detection module to perform optical detection on the mixed liquid after the urine and the detection reagent react in the reaction chamber to obtain detection data, including: The light source in the optical detection module emits a test light toward the reaction chamber, and the test light passes through the mixed liquid in the reaction chamber and then irradiates the chromatographic sensor to obtain detection data.

6. A urine analysis device, characterized in that: A microfluidic chip comprising any one of claims 1 to 3, a plurality of reagent capsules and a processor, wherein the plurality of reagent capsules are respectively mounted on the reagent holes of the microfluidic chip, and the processor is connected to an optical detection module in the microfluidic chip; The processor is used to control the detection reagent in the reagent capsule to flow into the reaction chamber through the corresponding reagent channel when urine flows in, and to control urine to flow into the reaction chamber through the urine channel, so that the detection reagent flowing into the reaction chamber reacts with the urine; The processor is also used to use the optical detection module to perform optical detection on the mixed liquid after the urine and the detection reagent react in the reaction chamber to obtain detection data; The processor is also used to receive multiple detection data returned by the microfluidic chip to obtain urine analysis data.

7. A toilet, characterized in that: The urine analysis device according to claim 6 is installed on the inner wall of the toilet.

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