Microfluidic chip, urine analysis method and device, toilet

Abstract

The embodiments of the present invention provide a microfluidic chip, a urine analysis method and device, and a toilet, which relate to the field of detection technology. The microfluidic chip includes: a chip body, an optical detection module fixed on the chip body, and a plurality of solenoid valves; the solenoid valve is used to control the reagent hole corresponding to the valve hole to open when a detection instruction is received, so that the detection reagent in the reagent capsule installed on the opened reagent hole flows into the reaction chamber through the corresponding reagent channel; the reaction chamber is used for the urine flowing into the microfluidic chip through the urine channel to react with the detection reagent in the reagent capsule; the optical detection module is used to perform optical detection on the mixed liquid after the reaction of urine and the detection reagent in the reaction chamber to obtain detection data. In the present invention, the microfluidic chip can perform at least one optical detection on the user's urine, so that the user's urine can be analyzed on a daily basis, so that the user can view the analysis data of the urine and understand his own physical health.

Description

Technical Field

[0001] The present invention relates to the field of detection technology, and in particular to a microfluidic chip, a urine analysis method and device, and a toilet. Background Art

[0002] Urine testing is a routine examination item for medical institutions to examine patients. By analyzing the patient's urine, the concentration of chemical components in the urine can be obtained, such as glucose, urine protein, pH value, occult blood, nitrite, bilirubin, urobilinogen, red blood cells, white blood cells, etc. The concentration of chemical components in human urine has a normal range. When the patient has a lesion or changes in eating habits, the chemical composition of the urine will also change accordingly, so the patient's health status can be judged by the concentration of chemical components in the patient's urine.

[0003] At present, the changes in the concentration of chemical components in urine can reflect the patient's health status to a certain extent. It is of great significance if the patient's health status can be judged in advance by monitoring the patient's urine before the patient feels abnormal in the body. Summary of the invention

[0004] The purpose of the present invention is to provide a microfluidic chip, a urine analysis method and device, and a toilet. The microfluidic chip can perform at least one optical detection on the user's urine, so that the user's urine can be analyzed on a daily basis, so that the user can view the urine analysis data and understand his or her own physical health status.

[0005] To achieve the above-mentioned object, the present invention provides a microfluidic chip, comprising: a chip body, an optical detection module fixed on the chip body, and a plurality of solenoid valves; a reaction cavity and a plurality of reagent channels connected to the reaction cavity are formed in the chip body, the plurality of reagent channels form a plurality of reagent holes on the chip body, the reaction cavity is also connected to a urine channel, the urine channel forms a urine hole on the chip body, each of the reagent holes is used to install a reagent capsule, the chip body is also formed with valve holes corresponding to the reagent holes, and each of the solenoid valves is respectively installed at each of the valve holes on the chip body; the solenoid valve is used to control the reagent hole corresponding to the valve hole to open when a detection instruction is received, so that the detection reagent in the reagent capsule installed on the opened reagent hole flows into the reaction cavity through the corresponding reagent channel; the reaction cavity is used for the urine flowing into the microfluidic chip through the urine channel to react with the detection reagent in the reagent capsule; the optical detection module is used to perform optical detection on the mixed liquid after the urine and the detection reagent react in the reaction cavity to obtain detection data.

[0006] The present invention also provides a urine detection method, comprising: applying the above-mentioned microfluidic chip, the method comprising: when receiving a detection instruction, controlling the corresponding reagent hole to open through the solenoid valve in the microfluidic chip, the detection reagent in the reagent capsule installed on the opened reagent hole flows into the reaction chamber through the corresponding reagent channel, urine flows into the reaction chamber through the urine channel, and the reagent flowing into the reaction chamber reacts with the urine; the optical detection module performs optical detection on the mixed liquid after the reaction of urine and the detection reagent in the reaction chamber to obtain detection data.

[0007] The present invention also provides a urine analysis device, comprising the above-mentioned microfluidic chip, a plurality of reagent capsules and a processor, wherein the plurality of reagent capsules are respectively installed on the reagent holes of the microfluidic chip, and the processor is connected to the optical detection module and the solenoid valve in the microfluidic chip; the processor is used to control the corresponding reagent hole to open through the solenoid valve in the microfluidic chip when urine flows in, so that the detection reagent in the reagent capsule installed on the reagent hole flows into the reaction chamber through the corresponding reagent channel, and controls urine to flow into the reaction chamber through the urine channel, and the detection reagent flowing into the reaction chamber reacts with urine; the processor is also used to use the optical detection module to optically detect the mixed liquid after the reaction of urine and the detection reagent in the reaction chamber to obtain detection data.

[0008] The present invention also provides a toilet, comprising the above-mentioned urine analysis device.

[0009] Compared with the prior art, the present invention provides a microfluidic chip with an optical detection function. The microfluidic chip includes a chip body, an optical detection module fixed on the chip body, and a plurality of solenoid valves. A reaction cavity and a plurality of reagent channels connected to the reaction cavity are formed in the chip body. The plurality of reagent channels form a plurality of corresponding reagent holes on the chip body. The reaction cavity is also connected to a urine channel. The urine channel forms a urine hole on the chip body. Each reagent hole is used to install a reagent capsule. When the solenoid valve receives a detection instruction, it controls the reagent hole corresponding to the valve hole to open, so that the detection reagent in the reagent capsule installed on the opened reagent hole flows into the reaction cavity through the corresponding reagent channel. After urine flows into the reaction cavity through the urine channel and the detection reagent in the reagent capsule to perform a chemical reaction, the optical detection module can perform optical detection on the mixed liquid after the reaction of urine and the detection reagent in the reaction cavity to obtain detection data, that is, the microfluidic chip can perform at least one optical detection on the user's urine, so that the user's urine can be analyzed on a daily basis, so that the user can view the analysis data of the urine and understand his own physical health status.

[0010] In one embodiment, the chip body includes an upper plate and a lower plate fixed to each other, the reaction chamber, the urine channel and the reagent channel are formed between the upper plate and the lower plate, the reagent hole and the urine hole are both formed on the upper surface of the upper plate, and the valve hole is formed on the lower surface of the lower plate.

[0011] In one embodiment, the microfluidic chip further includes: a control circuit board; the control circuit board is fixed to the lower plate; each of the solenoid valves includes: an armature, an elastic device, a shell, an electromagnetic coil and a magnetic core; a closed shell is provided at each valve hole of the lower plate, the elastic device and the armature are both provided in the shell, the armature is provided on the elastic device, the shell is fixed on the control circuit board, the shell is a hollow cylinder, the electromagnetic coil is fixed on the inner surface of the hollow cylinder, the magnetic core is located inside the hollow cylinder and fixed on the control circuit board; when the control circuit board is fixed to the lower plate, the shell is located in the electromagnetic coil and contacts the magnetic core; when the solenoid valve is in an open state, the armature moves toward the magnetic core, the elastic device is compressed by the armature, the reagent hole corresponding to the solenoid valve is opened, and the detection reagent in the reagent capsule installed on the reagent hole flows into the reaction chamber through the corresponding reagent channel; when the solenoid valve is in a closed state, the elastic device is in an initial state, and the armature closes the reagent hole corresponding to the solenoid valve.

[0012] In one embodiment, the optical detection module includes: a light source and a chromatographic sensor; the light source is fixed on the upper plate at a position corresponding to the reaction cavity, and the chromatographic sensor is fixed on the lower plate at a position corresponding to the reaction cavity; when optically detecting the mixed liquid in the reaction cavity, the light source emits a test light toward the reaction cavity, and the test light passes through the mixed liquid in the reaction cavity and then irradiates the chromatographic sensor.

[0013] In one embodiment, the reaction chamber forms a plurality of light-transmitting upper detection points on the upper plate, and the reaction chamber forms a plurality of light-transmitting lower detection points on the lower plate, and the upper detection points correspond to the lower detection points one by one; the test light emitted by the light source toward the reaction chamber passes through the upper detection points, the mixed liquid in the reaction chamber, and the lower detection points to irradiate the chromatographic sensor.

[0014] In one embodiment, a cleaning inlet channel and a cleaning outlet channel connected to the reaction chamber are respectively formed in the chip body, the cleaning inlet channel forms a cleaning inlet on the chip body, and the cleaning outlet channel forms a cleaning outlet on the chip body; the cleaning inlet channel is used for cleaning the reaction chamber with the cleaning liquid flowing in from the cleaning inlet; the cleaning outlet channel is used for the cleaning liquid in the reaction chamber to flow out from the cleaning outlet.

[0015] In one embodiment, an air duct connected to the reaction chamber is also formed in the chip body; the air channel is used to supply air to enter the reaction chamber from the air inlet after the reaction chamber is cleaned, so as to discharge the liquid in the reaction chamber.

[0016] In one embodiment, multiple reagent wells share one reagent channel. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 is a schematic diagram of a urine analysis device and a toilet applied to the microfluidic chip in the first embodiment of the present invention;

[0018] Figure 2 is a schematic structural diagram of a microfluidic chip according to a first embodiment of the present invention;

[0019] Figure 3 is a schematic structural diagram of an upper plate of a chip body of a microfluidic chip according to a first embodiment of the present invention;

[0020] Figure 4 is a schematic structural diagram of a lower plate of a chip body of a microfluidic chip according to a first embodiment of the present invention;

[0021] Figure 5 and Figure 6 is a schematic structural diagram of a urine analysis device applied to the microfluidic chip in the first embodiment of the present invention;

[0022] Figure 7 is a schematic structural diagram of a microfluidic chip according to a second embodiment of the present invention;

[0023] Figure 8 is a schematic structural diagram of an upper plate of a chip body of a microfluidic chip according to a third embodiment of the present invention;

[0024] Fig. 9 is a specific flow chart of the urine detection method according to the fourth embodiment of the present invention;

[0025] Fig.10 is a schematic diagram of a toilet according to a fifth embodiment of the present invention;

[0026] Fig.11 Schematic diagram of a urine analysis device in a toilet according to a fifth embodiment of the present invention. DETAILED DESCRIPTION

[0027] The following will be described in detail with reference to the accompanying drawings to provide a clearer understanding of the purpose, features and advantages of the present invention. It should be understood that the embodiments shown in the accompanying drawings are not intended to limit the scope of the present invention, but are only intended to illustrate the essential spirit of the technical solution of the present invention.

[0028] In the following description, certain specific details are set forth for the purpose of illustrating various disclosed embodiments to provide a thorough understanding of the various disclosed embodiments. However, those skilled in the relevant art will recognize that the embodiments may be practiced without one or more of these specific details. In other cases, well-known devices, structures, and techniques associated with the present application may not be shown or described in detail to avoid unnecessarily obscuring the description of the embodiments.

[0029] Unless the context requires otherwise, throughout the specification and claims, the word "comprise" and variations such as "include" and "have" should be construed in an open, inclusive sense, ie, should be interpreted as "including, but not limited to."

[0030] References throughout the specification to "one embodiment" or "an embodiment" indicate that a particular feature, structure, or characteristic described in connection with the embodiment is included in at least one embodiment. Thus, the appearances of "in one embodiment" or "in an embodiment" in various places throughout the specification are not necessarily all referring to the same embodiment. Furthermore, the particular features, structures, or characteristics may be combined in any manner in one or more embodiments.

[0031] As used in this specification and the appended claims, the singular forms "a," "an," and "" include plural referents unless the context clearly dictates otherwise. It should be noted that the term "or" is generally employed in its sense including "and / or" unless the context clearly dictates otherwise.

[0032] In the following description, in order to clearly show the structure and working mode of the present invention, many directional words will be used for description, but the words "front", "back", "left", "right", "outside", "inside", "outward", "inward", "up", "down", etc. should be understood as convenient terms and should not be understood as restrictive terms.

[0033] The first embodiment of the present invention relates to a microfluidic chip for optical detection of urine, such as Figure 1As shown, the microfluidic chip can be arranged in a urine analysis device 10, and the urine analysis device 10 is assembled in a toilet 20. For example, the urine analysis device 10 is fixed to the inner wall of the toilet 20 by bonding. An opening 11 is formed on the shell of the urine analysis device 10 so that each time the user uses the toilet, the urine analysis device 10 can collect the user's urine through the opening 11 and input it into the microfluidic chip, and the microfluidic chip then performs optical detection on the urine.

[0034] The microfluidic chip comprises a chip body, an optical detection module fixed on the chip body, and a plurality of solenoid valves.

[0035] A reaction cavity and a plurality of reagent channels connected to the reaction cavity are formed in the chip body, the plurality of reagent channels form a plurality of reagent holes on the chip body, the reaction cavity is also connected to a urine channel, the urine channel forms a urine hole on the chip body, each of the reagent holes is used to install a reagent capsule, and valve holes corresponding to the reagent holes are also formed on the chip body, and the solenoid valves are respectively installed at the valve holes on the chip body.

[0036] The solenoid valve is used to control the reagent hole corresponding to the valve hole to open when a detection instruction is received, so that the detection reagent in the reagent capsule installed on the opened reagent hole flows into the reaction chamber through the corresponding reagent channel.

[0037] The reaction chamber is used for the urine flowing into the microfluidic chip through the urine channel to react with the detection reagent in the reagent capsule; the optical detection module is used for optically detecting the mixed liquid after the urine and the detection reagent react in the reaction chamber to obtain detection data.

[0038] Combine the following Figures 2 to 4 Microfluidic chips and Figure 5 , Figure 6 The specific structure diagram of the urine analysis device is described in detail.

[0039] The chip body includes an upper plate 101 and a lower plate 102 fixed to each other, a reaction chamber 103, a urine channel 104 and a reagent channel 105 are formed between the upper plate 101 and the lower plate 102, the reagent hole 106 and the urine hole 107 are both formed on the upper surface of the upper plate 101, and a reagent capsule 3 is installed in each reagent hole 106. The valve hole 121 forms the lower surface of the lower plate 102, and each solenoid valve 4 of the microfluidic chip is respectively installed on each valve hole 121, and each solenoid valve 4 is used to control the opening or closing of the corresponding reagent hole 106; in addition, the lower surface of the lower plate 102 also has a valve hole 121 corresponding to the urine hole 107, and the valve hole 121 is also installed with a solenoid valve 4, which is used to control the opening or closing of the urine hole 107. A channel fence 1012 is provided between the upper plate 101 and the lower plate 102, and the channel fence 1012 forms a plurality of channels for liquid in the chip body; the urine channel 104 and the reagent channel 105 share a portion of the channels in the chip body.

[0040] The optical detection module includes: a light source 21 and a chromatographic sensor 22. The light source 21 is fixed on the upper plate 101 at a position corresponding to the reaction chamber 103, and the chromatographic sensor 22 is fixed on the lower plate 102 at a position corresponding to the reaction chamber 103. The light source 21 can be a laser, a light emitting diode, a halogen tungsten lamp, etc. The chromatographic sensor 22 includes a light detector and a wavelength selector. The light detector can convert the optical signal into an electrical signal, such as a photomultiplier tube, a photodiode, a CMOS sensor, etc.; the wavelength selector is used to select the wavelength of the incident light, and the wavelength selector is, for example, a grating, a triangular prism or a filter.

[0041] When optical detection is performed on the mixed liquid in the reaction chamber 103 , the light source 21 emits a test light toward the reaction chamber 103 , and the test light passes through the mixed liquid in the reaction chamber 103 and then irradiates the chromatographic sensor 22 .

[0042] In one example, the reaction chamber 103 forms a plurality of light-transmitting upper detection points 1031 on the upper plate 101, and the reaction chamber 103 forms a plurality of light-transmitting lower detection points 1032 on the lower plate 102, and the upper detection points 1031 correspond to the lower detection points 1032 one by one. Figure 3 and Figure 4 As shown, the number of upper detection points 1031 and lower detection points 1032 is three for example. The test light emitted by the light source 21 toward the reaction chamber 103 passes through the upper detection point 1031 , the mixed liquid in the reaction chamber 103 and the lower detection point 1032 to irradiate the chromatographic sensor 22 .

[0043] In this embodiment, the microfluidic chip also includes a control circuit board 5, and the control circuit board 5 is fixed to the lower plate 102, and the fixing method can be fixed by screws. Each solenoid valve 4 of the microfluidic chip is installed on the control circuit board 5, and the processor 6 in the urine analysis device is installed on the main circuit board 6. The control circuit board 5 is fixed and electrically connected to the main circuit board 7, so that the processor 6 can control the opening or closing of each solenoid valve 4. It should be noted that the control circuit board 5 and the main circuit board 7 in this embodiment also include peripheral circuits, interfaces and other components, which are not described one by one here. In addition, the urine analysis device also includes a shell, and the shell includes an upper shell 81 and a lower shell 82, and an opening 11 is formed on the upper shell 81.

[0044] When the user uses the toilet, the user's urine flows into the urine analysis device through the opening 11 on the upper shell 81 of the urine analysis device, and the processor 6 inputs the urine into the microfluidic chip multiple times based on the items to be detected. When each item of urine is detected, the corresponding reagent hole 106 is opened by controlling the solenoid valve 4 to open, so that the detection reagent in the reagent capsule 3 installed on the opened reagent hole 106 flows into the reaction chamber 103 of the microfluidic chip, so that the urine flowing into the reaction chamber 103 can react chemically with the detection reagent.

[0045] Specifically, when the user uses the toilet, urine flows in through the opening 11 of the urine analysis device, and the processor 6 in the urine molecule device is connected to the optical detection module of the microfluidic chip; the processor 6 can control the urine to flow into the reaction chamber 103 of the microfluidic chip, and at the same time, the processor 6 will open the reagent hole 106 by controlling the solenoid valve 4 to control the detection reagent in the reagent capsule 3 to flow into the reaction chamber 103 of the microfluidic chip, and the urine flowing into the reaction chamber 103 of the microfluidic chip reacts chemically with the detection reagent, and the processor 6 then sends a detection instruction to the optical detection module of the microfluidic chip. After receiving the detection instruction, the light source 21 in the optical detection module emits a test light of a preset wavelength (generally diffuse light) toward the reaction chamber 103, and the test light is shot into the reaction chamber through each upper detection point 1031. The light is reflected in the cavity 103 and in the mixed liquid in the reaction cavity 103. The reflected light is irradiated onto the spectral sensor 22 through the lower detection point 1032. The wavelength selection in the spectral sensor 22 first selects the light of the set wavelength from the incident light, and then converts the light of the set wavelength into an electrical signal, which is the detection data. After generating the detection data, the spectral sensor 22 sends the detection data to the processor 6. In a urine analysis, multiple tests need to be performed on the urine. At this time, multiple reagent capsules 3 installed on the microfluidic chip are filled with multiple detection reagents. The multiple detection reagents react with the urine in the reaction cavity 103 respectively. The optical detection module also performs multiple optical detections on the urine to obtain multiple detection data, so that the processor 6 can generate urine analysis results based on the multiple detection data for the user to view.

[0046] Compared with the prior art, this embodiment provides a microfluidic chip with an optical detection function. The microfluidic chip includes a chip body, an optical detection module fixed on the chip body, and a plurality of solenoid valves. A reaction cavity and a plurality of reagent channels connected to the reaction cavity are formed in the chip body. The plurality of reagent channels form a plurality of corresponding reagent holes on the chip body. The reaction cavity is also connected to a urine channel. The urine channel forms a urine hole on the chip body. Each reagent hole is used to install a reagent capsule. When the solenoid valve receives a detection instruction, it controls the reagent hole corresponding to the valve hole to open, so that the detection reagent in the reagent capsule installed on the opened reagent hole flows into the reaction cavity through the corresponding reagent channel. After urine flows into the reaction cavity through the urine channel and the detection reagent in the reagent capsule to perform a chemical reaction, the optical detection module can perform optical detection on the mixed liquid after the reaction of urine and the detection reagent in the reaction cavity to obtain detection data, that is, the microfluidic chip can perform at least one optical detection on the user's urine, so that the user's urine can be analyzed on a daily basis, so that the user can view the analysis data of the urine and understand his own physical health status.

[0047] The second embodiment of the present invention relates to a microfluidic chip. The main difference between this embodiment and the first embodiment is that: Figure 7 Each of the electromagnetic valves 4 comprises an armature 41, an elastic device 42, a housing 43, an electromagnetic coil 44 and a magnetic core 45. The elastic device 42 can be a device with elastic force such as a spring.

[0048] A closed shell 122 is provided at each valve hole 121 of the lower plate 102, the elastic device 42 and the armature 41 are both provided in the shell 122, the armature 41 is provided on the elastic device 42, the shell 43 is fixed on the control circuit board 5, the shell 43 is a hollow cylinder, the electromagnetic coil 44 is fixed on the inner surface of the hollow cylinder, the magnetic core 45 is located inside the hollow cylinder and fixed on the control circuit board 5; when the control circuit board 5 is fixed to the lower plate 102, the shell 122 is located in the electromagnetic coil 44 and contacts the magnetic core 45.

[0049] When the solenoid valve 4 is in an open state, the armature 41 moves toward the magnetic core 45, the elastic device 42 is compressed by the armature 41, the reagent hole 106 corresponding to the solenoid valve 4 is opened, and the detection reagent in the reagent capsule 3 installed on the reagent hole 106 flows into the reaction chamber 103 through the corresponding reagent channel.

[0050] When the solenoid valve 4 is in a closed state, the elastic device 42 is in an initial state, and the armature 41 closes the reagent hole 106 corresponding to the solenoid valve 4 .

[0051] When the processor 6 needs to control the detection reagent in a certain reagent capsule 3 to flow into the reaction chamber 103, the corresponding solenoid valve 4 can be energized, the coil in the solenoid valve 4 generates a magnetic field, the magnetic core 45 attracts the armature 41 to move toward it, and the elastic device 42 is compressed by the armature 41 from the initial state, so that the reagent hole 106 closed by the armature 41 is opened, and the detection reagent in the reagent capsule 3 installed in the reagent hole 106 flows into the reaction chamber 103. Subsequently, when the processor 6 controls the solenoid valve 4 to be powered off, the magnetic core 45 no longer generates attraction to the armature 41, and the elastic device 42 returns to the initial state. At this time, the armature 41 closes the corresponding reagent hole 106 under the elastic force of the elastic device 42. It should be noted that the opening and closing of the urine hole 107 is similar to the above, and will not be repeated here.

[0052] The third embodiment of the present invention relates to a microfluidic chip. The main difference between this embodiment and the first embodiment is that: Figure 8A cleaning inlet channel and a cleaning outlet channel connected to the reaction chamber 103 are respectively formed in the chip body. The cleaning inlet channel forms a cleaning inlet 108 on the upper surface of the upper plate 101 of the chip body, and the cleaning outlet channel forms a cleaning outlet 109 on the upper surface of the upper plate 101 of the chip body.

[0053] The cleaning inlet channel is used for cleaning the reaction chamber 103 with the cleaning liquid flowing in from the cleaning inlet 108 .

[0054] The cleaning outlet channel 109 is used for allowing the cleaning liquid in the reaction chamber 103 to flow out from the cleaning outlet 109 .

[0055] In one example, an air channel connected to the reaction chamber is further formed in the chip body, and the air channel forms an air inlet 110 on the upper surface of the upper plate 101 of the chip body.

[0056] The air channel 112 is used to supply air from the air inlet 110 to enter the reaction chamber 103 after the reaction chamber 103 is cleaned, so as to discharge the liquid in the reaction chamber 103 .

[0057] In one example, a cleaning liquid connection channel and a waste liquid channel are also formed in the chip body of the microfluidic chip. The cleaning liquid connection channel forms a cleaning liquid interface 111 on the upper surface of the upper plate 101 of the chip body, and the waste liquid channel forms a waste liquid outlet 112 on the upper surface of the upper plate 101 of the chip body. In addition, a vent channel is also formed in the chip body of the microfluidic chip, and the vent channel 118 forms a vent port 113 on the upper surface of the upper plate 101 of the chip body.

[0058] Combine the following Figure 5 and Figure 6 The urine analysis device of the microfluidic chip application shown is described in detail.

[0059] In this embodiment, the cleaning inlet 108 and the cleaning outlet are connected to a cleaning pump (for example, a diaphragm pump) in the urine analysis device, the cleaning liquid interface 111 is connected to a cleaning liquid storage device for storing cleaning liquid in the urine analysis device, and the waste liquid outlet 112 is connected to one end of a peristaltic pump in the urine analysis device, and the other end of the peristaltic pump is connected to the waste liquid storage device in the urine analyzer.

[0060] The reagent hole 106, urine hole 107, waste liquid outlet 112, cleaning liquid connection port 111, cleaning inlet 108, cleaning outlet 109, air inlet 110 and vent 113 on the microfluidic chip are all controlled to open or close by the corresponding solenoid valve 4. Each solenoid valve 4 is respectively installed on each valve hole 121 on the lower plate 102. The solenoid valve 4 is used to control the opening or closing of each opening or hole on the upper plate 101.

[0061] When no urine enters the urine analysis device, except for the solenoid valve 4 corresponding to the air vent 113 on the microfluidic chip, which is in an open state, the other solenoid valves 4 are in a closed state. When urine enters the urine storage device in the urine analysis device through the opening 11 on the shell, the processor 6 controls the solenoid valve 4 corresponding to the air vent 113 to close, and controls the solenoid valve 4 corresponding to the urine hole 107 to open, controls the peristaltic pump to pump out a first preset proportion of urine from the urine storage device to the reaction chamber 103, and then closes the solenoid valve 4 corresponding to the urine hole 107, and then controls the solenoid valve 4 corresponding to the reagent capsule 3 of the current detection item to open, and controls the peristaltic pump to pump out a second preset proportion of detection reagent from the reagent capsule 3 to the reaction chamber 103, and then closes the solenoid valve 4 corresponding to the reagent capsule 3; at this time, the detection reagent reacts with the urine in the reaction chamber 103, and the processor 6 controls the optical detection module in the microfluidic chip to the reaction chamber 103. The mixed liquid after the reaction of urine and the detection reagent in 103 is optically detected, and the optical detection module sends the detection data obtained by the optical detection to the processor 6. The processor 6 determines that the current detection project is completed, and first controls the peristaltic pump to pump out the mixed liquid after the reaction from the reaction chamber 103 to the waste liquid storage; then, controls to open the solenoid valve 4 of the cleaning liquid connection port 111 and the cleaning inlet 108, and controls the cleaning pump to pump out the cleaning liquid from the cleaning liquid storage to clean the reaction chamber 103 of the microfluidic chip, and then closes the cleaning liquid connection port 111 and the solenoid valve 4 of the cleaning inlet 108; then opens the solenoid valve 4 of the cleaning outlet 109, controls the cleaning pump to pump out the cleaning liquid in the reaction chamber 103, and then closes the solenoid valve 4 of the cleaning outlet 109, and then opens the solenoid valve 4 corresponding to the air inlet 27, and the cleaning pump pumps air to discharge and dry the liquid in the reaction chamber 103, and then closes the solenoid valve 4 corresponding to the air inlet 27. Then the processor 6 performs the detection of the next detection item, controls the solenoid valve 4 corresponding to the urine hole 107 to open, controls the peristaltic pump to pump out the first preset proportion of urine from the urine storage device to the reaction chamber 103, and then closes the solenoid valve 4 corresponding to the urine hole 107, and then controls the solenoid valve 4 corresponding to the reagent capsule 3 of the next detection item to open, and controls the peristaltic pump to pump out the second preset proportion of detection reagent from the reagent capsule 3 to the reaction chamber 103, and then closes the solenoid valve 4 corresponding to the reagent capsule 3, and repeats the above process to complete the optical detection. After each detection item is completed, the reaction chamber 103 is cleaned, and then the next detection item is detected after cleaning, until all detection items are completed, and the processor 6 summarizes the detection data of multiple detection items in this urine detection, and then obtains the urine analysis data of this urine detection based on these multiple detection data.

[0062] In this embodiment, the types of detection reagents in the multiple reagent capsules correspond one-to-one to the multiple second preset ratios, that is, based on different detection items, the amount of detection reagents required each time is different. Therefore, the processor 6 controls the peristaltic pump to pump different reagents from different reagent capsules 3 into the reaction chamber 103 in different ratios, so as to avoid the amount of detection reagents affecting the detection data of optical detection, thereby ensuring the accuracy of urine analysis to a certain extent.

[0063] The fourth embodiment of the present invention relates to a urine detection method, which is applied to the microfluidic chip described in any one of the first to third embodiments.

[0064] Please refer to Fig. 9 , is a specific flow chart of the urine detection method of this embodiment.

[0065] Step 101, when a detection instruction is received, the corresponding reagent hole is controlled to open by the solenoid valve in the microfluidic chip, the detection reagent in the reagent capsule installed on the opened reagent hole flows into the reaction chamber through the corresponding reagent channel, and urine flows into the reaction chamber through the urine channel, and the reagent flowing into the reaction chamber reacts with the urine.

[0066] Step 102: The optical detection module performs optical detection on the mixed liquid after the urine and the detection reagent react in the reaction chamber to obtain detection data.

[0067] Specifically, the light source in the optical detection module is used to emit a test light toward the reaction chamber, and the test light passes through the mixed liquid in the reaction chamber and then irradiates the chromatographic sensor to obtain detection data.

[0068] Please refer to Figures 1 to 6When the user uses the toilet, urine flows in through the opening 11 of the urine analysis device, and the processor 6 in the urine molecule device is connected to the optical detection module of the microfluidic chip; the processor 6 can control the urine to flow into the reaction chamber 103 of the microfluidic chip, and at the same time, the processor 6 will open the reagent hole 106 by controlling the solenoid valve 4 to control the detection reagent in the reagent capsule 3 to flow into the reaction chamber 103 of the microfluidic chip, and the urine flowing into the reaction chamber 103 of the microfluidic chip reacts chemically with the detection reagent. The processor 6 then sends a detection instruction to the optical detection module of the microfluidic chip. After receiving the detection instruction, the light source 21 in the optical detection module sends a test light (generally diffuse light) of a preset wavelength toward the reaction chamber 103, and the test light is shot into the reaction chamber through each upper detection point 1031. 103, and is reflected in the mixed liquid in the reaction chamber 103. The reflected light is irradiated onto the spectral sensor 22 through the lower detection point 1032. The wavelength selection in the spectral sensor 22 first selects the light of the set wavelength from the incident light, and then converts the light of the set wavelength into an electrical signal, which is the detection data. After generating the detection data, the spectral sensor 22 sends the detection data to the processor 6. In a urine analysis, multiple tests need to be performed on the urine. At this time, multiple reagent capsules 3 installed on the microfluidic chip are filled with multiple detection reagents. The multiple detection reagents react with the urine in the reaction chamber 103 respectively. The optical detection module also performs multiple optical detections on the urine to obtain multiple detection data, so that the processor 6 can generate urine analysis results based on the multiple detection data for the user to view.

[0069] Compared with the prior art, the present embodiment provides a urine detection method based on a microfluidic chip with an optical detection function. When the solenoid valve receives a detection instruction, it controls the reagent hole corresponding to the valve hole to open, so that the detection reagent in the reagent capsule installed on the opened reagent hole flows into the reaction chamber through the corresponding reagent channel. After urine flows into the reaction chamber through the urine channel and the detection reagent in the reagent capsule for chemical reaction, the optical detection module can perform optical detection on the mixed liquid after the reaction of urine and the detection reagent in the reaction chamber to obtain detection data, that is, the microfluidic chip can perform at least one optical detection on the user's urine, so that the user's urine can be analyzed on a daily basis, so that the user can view the urine analysis data and understand his or her own physical health status.

[0070] A fifth embodiment of the present invention relates to a urine analysis device for testing a user's urine, such as Figure 1 As shown, the urine analysis device 10 is assembled in the toilet 20. For example, the urine analysis device 10 is fixed to the inner wall of the toilet 20 by bonding, so that the user's urine can be collected for testing every time the user uses the toilet.

[0071] Please refer to Figure 5 and Figure 6 The urine analysis device includes the microfluidic chip of the first embodiment or the second embodiment, a plurality of reagent capsules 3 and a processor 6. In addition, the urine analysis device also includes a housing, which includes an upper housing 81 and a lower housing 82, and an opening 11 is formed on the upper housing 81.

[0072] The processor 6 is used to control the detection reagent in the reagent capsule 3 to flow into the reaction chamber 103 through the corresponding reagent channel when urine flows in, and to control urine to flow into the reaction chamber 103 through the urine channel, so that the detection reagent flowing into the reaction chamber 103 reacts with the urine.

[0073] The processor 6 is further used to use the optical detection module to perform optical detection on the mixed liquid after the urine and the detection reagent in the reaction chamber 103 to obtain detection data.

[0074] The processor 6 is also used to receive a plurality of detection data returned by the microfluidic chip to obtain urine analysis data.

[0075] In one example, the urine analysis device is also provided with a wireless communication module (not shown in the figure, the wireless communication module can be installed on the circuit board 7), such as WIFI, 4G, 5G, etc., so that the processor 6 can be connected to the cloud server by wireless, and the urine analysis data obtained from each urine test is sent to the cloud server, and the cloud server monitors the urine analysis data of the user for a long period of time, such as 7 days, 15 days, 30 days, etc. In addition, the user can also connect electronic devices such as mobile phones and computers to the urine analysis device, so that the processor 6 can also send the urine analysis data to the user's electronic device, so that the user can view his own urine analysis data in real time and view his own physical condition through the urine analysis data.

[0076] In this embodiment, different types of detection reagents can be respectively contained in multiple reagent capsules 4, and the types of detection reagents can be set according to the detection items of urine. For example, the detection reagents used for urine creatinine detection are creatinine colorimetric solution and creatinine analysis buffer solution; the detection reagent used for urine protein detection is sulfosalicylic acid solution; the detection reagent used for urine pH detection is bromothymol blue solution; the detection reagent used for urine ketone body detection is 10% concentration of ferric chloride; the detection reagent used for vitamin C detection is acid buffer solution, phenanthroline colorimetric solution and VC analysis buffer solution; the detection reagent used for urine nitrite detection is Griess solution; it should be noted that the above only lists some detection items and the required detection reagents, and the detection items can be increased or decreased as needed, such as adding the detection of urine albumin and urine hemoglobin.

[0077] It should be noted that the urine analysis device in this embodiment may also include a battery holder (not shown in the figure), which is connected to the circuit board 202. When the battery is installed in the battery holder, the battery can power the processor 6 in the urine analysis device and the optical detection module 204, valve 201, etc. in the microfluidic chip. In addition, the urine analysis device in this embodiment may also include a residual sensor for detecting the residual amount of the detection reagent in each reagent capsule 4, and each residual sensor is connected to the processor 6, so that the processor 6 can issue a prompt in time when the residual amount of the detection reagent in any reagent capsule 4 is insufficient. The reminder method is, for example, sending a prompt message through a cloud server or directly to the electronic device of the connected user.

[0078] For an example, see Fig.10 The urine analysis device further includes: a power supply receiving module 901 and a power supply 902, and the power supply receiving module 901 is connected to the processor 6 and the microfluidic chip respectively.

[0079] The urine analysis device 10 is mounted on the inner wall of the toilet 20, and the power receiving module 901 is fixed in a preset area inside the shell, that is, the power receiving module 901 is mounted in a preset area on the lower shell 31 of the shell, and the preset area is located in the area of ​​the lower shell 82 of the shell close to the inner wall of the toilet 20; the power receiving module 901 is mounted on the outer wall of the toilet 20, and the power supply 902 corresponds to the position of the power receiving module 901. The power supply 902 can be fixed to the toilet 20 by adhesion.

[0080] The power supply 902 is used to provide power to the power receiving module 901 .

[0081] The power receiving module 901 is used to use the received electric energy to power the processor 6 and the microfluidic chip respectively.

[0082] Please refer to Fig.11 In this example, electromagnetic induction can be used for wireless power supply. The power supply receiving module 901 includes a charging chip 9011 and a wireless receiving coil 9012. The charging chip 9011 is arranged on the circuit board 7. The wireless receiving coil 9012 is fixed on the shell 82 and is located inside the urine analysis device. The wireless receiving coil 9012 is connected to the circuit board 7 of the urine analysis device 10. The wireless receiving coil 9012 is connected to the charging chip 9011 through the wiring on the circuit board 7. The power supply 102 is provided with a wireless transmitting coil and a battery pack (not shown in the figure). The battery pack is connected to the wireless transmitting coil. The wireless transmitting coil converts the electric energy of the battery pack into a magnetic field. The wireless receiving coil 9012 induces an alternating current due to the existence of the alternating magnetic field. Then, the wireless charging chip 9011 on the circuit board 7 converts the alternating current into direct current to power the processor 6 and the microfluidic chip respectively.

[0083] It should be noted that Fig.11 The positions of the charging chip 9011 and the wireless receiving coil 9012 are only schematically described, but are not limited to this. A power supply circuit board for fixing the charging chip 9011 may also be provided. The wireless receiving coil 9012 is fixed on the shell 82 and located inside the urine analysis device. The wireless receiving coil 1012 is connected to the charging chip 9011 through the power supply circuit board.

[0084] In this embodiment, the power supply 902 uses the power receiving module 901 to wirelessly power the urine analysis device 10, so that the user can maintain the power supply of the urine analysis device 10 by charging the power supply 902, which is more convenient and quick, and easy for the user to operate. Among them, the battery pack in the power supply 902 can be a rechargeable battery pack. In this case, a charging interface is provided on the power supply 902, and the power supply 902 can be connected to an external power supply through a charging cable, and the external power supply charges the rechargeable battery pack.

[0085] In this embodiment, the types of detection reagents in multiple reagent capsules correspond one-to-one to multiple second preset ratios, that is, based on different detection items, the amount of detection reagents required each time is different. Therefore, the processor 6 controls the peristaltic pump to pump different ratios of reagents from different reagent capsules into the reaction chamber, so as to avoid the amount of detection reagents affecting the detection data of optical detection, thereby ensuring the accuracy of urine analysis to a certain extent.

[0086] In one example, a temperature sensor (not shown in the figure) is also provided in the urine analysis device. The temperature sensor is provided at the opening 11 or at a position near the opening 11 in the housing, and is connected to the circuit board 7, so that the processor 6 is electrically connected to the temperature sensor through the circuit board 7. When no user uses the toilet 20, the temperature detected by the temperature sensor is the indoor temperature, and the indoor temperature value is sent to the processor 6; when a user uses the toilet 20, urine flows into the urine analysis device from the opening 11, and the temperature sensor detects the user's urine temperature value, and sends the detected urine temperature value to the processor 6. The urine temperature value is greater than the indoor temperature. The processor 6 determines that the detected temperature value increases, and the difference between the urine temperature value and the indoor temperature value is greater than or equal to the preset first temperature threshold, and determines that urine is detected to flow into the urine analysis device. The processor 6 controls the urine analysis device to enter the detection state and wakes up the microfluidic chip to perform urine detection. Among them, the first temperature threshold is, for example, 2 degrees, 5 degrees, 10 degrees, etc.

[0087] In one example, the processor 6 is also used to control the urine analysis device to enter a standby state after receiving multiple detection data returned by the microfluidic chip and obtaining urine analysis data, if the temperature value sent by the temperature sensor is lowered and the temperature reduction value is greater than or equal to a preset second temperature threshold. Specifically, when the urine test is completed, if the user flushes at this time, the temperature sensor detects the water temperature value and sends it to the processor 6. The water temperature value sent by the temperature sensor received by the processor 6 is less than the urine temperature value. It is determined that the temperature has dropped and the temperature reduction value is greater than or equal to the preset second temperature threshold, indicating that the user has finished using the toilet. The urine analysis device is controlled to enter a standby state again, thereby reducing the power consumption of the urine analysis device. The second temperature threshold is, for example, 2 degrees, 5 degrees, 10 degrees, etc.

[0088] In one example, the processor 6 is also used to adjust the first temperature threshold and the second temperature threshold according to the currently detected temperature value when the temperature value sent by the temperature sensor remains unchanged within a preset time. Specifically, when the user has not used the toilet for a long time, the temperature detected by the temperature sensor at this time is the indoor temperature at this time. Since the indoor temperature changes with the seasons, and the human urine temperature is basically maintained constant, the first temperature threshold and the second temperature threshold can be adjusted in real time according to the indoor temperature value. For example, in summer, the indoor temperature is higher, and the temperature difference between the indoor temperature and the urine temperature is reduced, and the first temperature threshold and the second temperature threshold can be appropriately reduced; in winter, the indoor temperature is lower, and the temperature difference between the indoor temperature and the urine temperature is increased, and the first temperature threshold and the second temperature threshold can be appropriately increased.

[0089] The urine analysis device in this embodiment can analyze the correlation data between the user's metabolism and the user's daily behavior state based on the urine analysis data collected continuously and for a long time. For example, the user's eating habits (including meals, nutrition, vitamins, tobacco and alcohol, etc.), disease conditions, work and rest rules, exercise habits, sleep status or medication status and other behavioral states will all be presented in the user's urine. When certain behavioral states of the user change, it will have a corresponding impact on the user's urine. The urine analysis device can also detect the changes in urine, and then the urine analysis device can analyze the correlation between the user's metabolism and the user's behavior state based on long-term and continuous urine analysis data.

[0090] Since the first to fourth embodiments correspond to this embodiment, this embodiment can be implemented in conjunction with the first to fourth embodiments. The relevant technical details mentioned in the first to fourth embodiments are still valid in this embodiment, and the technical effects that can be achieved in the first to fourth embodiments can also be achieved in this embodiment. In order to reduce repetition, they are not repeated here. Accordingly, the relevant technical details mentioned in this embodiment can also be applied in the first to fourth embodiments.

[0091] The fifth embodiment of the present invention relates to a toilet, comprising the urine analysis device of the fourth embodiment of claim 1. Figure 1 The urine analysis device 10 is assembled in the toilet 20. For example, the urine analysis device 10 is fixed to the inner wall of the toilet 20 by bonding, so that the user's urine can be collected for detection every time the user uses the toilet.

[0092] Since the first to fifth embodiments correspond to this embodiment, this embodiment can be implemented in conjunction with the first to fifth embodiments. The relevant technical details mentioned in the first to fifth embodiments are still valid in this embodiment, and the technical effects that can be achieved in the first to fifth embodiments can also be achieved in this embodiment. In order to reduce repetition, they will not be repeated here.

[0093] Preferred embodiments of the present invention have been described above in detail, but it should be understood that aspects of the embodiments can be modified, if necessary, to employ aspects, features and concepts of the various patents, applications and publications to provide further embodiments.

[0094] These and other changes can be made to the embodiments in light of the above detailed description.In general, in the claims, the terms used should not be considered limited to the specific embodiments disclosed in the specification and the claims, but should be construed to include all possible embodiments along with the full scope of equivalents to which these claims are entitled.

Claims

1. A microfluidic chip, characterized in that: include: A chip body, an optical detection module fixed on the chip body, and a plurality of solenoid valves; A reaction cavity and a plurality of reagent channels connected to the reaction cavity are formed in the chip body, the plurality of reagent channels form a plurality of reagent holes on the chip body, the reaction cavity is also connected to a urine channel, the urine channel forms a urine hole on the chip body, each reagent hole is used to install a reagent capsule, the chip body is also formed with valve holes corresponding to the reagent holes, and each solenoid valve is respectively installed at each valve hole on the chip body; The solenoid valve is used to control the reagent hole corresponding to the valve hole to open when receiving a detection instruction, so that the detection reagent in the reagent capsule installed on the opened reagent hole flows into the reaction chamber through the corresponding reagent channel; The reaction chamber is used for the urine flowing into the microfluidic chip through the urine channel to react with the detection reagent in the reagent capsule; The optical detection module is used to perform optical detection on the mixed liquid after the urine and the detection reagent react in the reaction chamber to obtain detection data.

2. The microfluidic chip according to claim 1, characterized in that: The chip body includes an upper plate and a lower plate fixed to each other, the reaction chamber, the urine channel and the reagent channel are formed between the upper plate and the lower plate, the reagent hole and the urine hole are both formed on the upper surface of the upper plate, and the valve hole is formed on the lower surface of the lower plate.

3. The microfluidic chip according to claim 2, characterized in that: The microfluidic chip further comprises: a control circuit board; the control circuit board is fixed to the lower plate; Each of the solenoid valves comprises: an armature, an elastic device, a housing, an electromagnetic coil and a magnetic core; A closed shell is provided at each valve hole of the lower plate, the elastic device and the armature are both provided in the shell, the armature is provided on the elastic device, the shell is fixed on the control circuit board, the shell is a hollow cylinder, the electromagnetic coil is fixed on the inner surface of the hollow cylinder, the magnetic core is located inside the hollow cylinder and is fixed on the control circuit board; when the control circuit board is fixed to the lower plate, the shell is located in the electromagnetic coil and is in contact with the magnetic core; When the solenoid valve is in an open state, the armature moves toward the magnetic core, the elastic device is compressed by the armature, the reagent hole corresponding to the solenoid valve is opened, and the detection reagent in the reagent capsule installed on the reagent hole flows into the reaction chamber through the corresponding reagent channel; When the solenoid valve is in a closed state, the elastic device is in an initial state, and the armature closes the reagent hole corresponding to the solenoid valve.

4. The microfluidic chip according to claim 2, characterized in that: The optical detection module comprises: a light source and a chromatographic sensor; the light source is fixed on a position on the upper plate corresponding to the reaction chamber, and the chromatographic sensor is fixed on a position on the lower plate corresponding to the reaction chamber; When optical detection is performed on the mixed liquid in the reaction chamber, the light source emits a test light toward the reaction chamber, and the test light passes through the mixed liquid in the reaction chamber and then irradiates the chromatographic sensor.

5. The microfluidic chip according to claim 4, characterized in that: The reaction chamber forms a plurality of light-transmitting upper detection points on the upper plate, and the reaction chamber forms a plurality of light-transmitting lower detection points on the lower plate, and the upper detection points correspond to the lower detection points one by one; The test light emitted by the light source toward the reaction chamber passes through the upper detection point, the mixed liquid in the reaction chamber, and the lower detection point to irradiate the chromatographic sensor.

6. The microfluidic chip according to claim 1, characterized in that: The chip body is also formed with a cleaning inlet channel and a cleaning outlet channel connected to the reaction chamber, the cleaning inlet channel forms a cleaning inlet on the chip body, and the cleaning outlet channel forms a cleaning outlet on the chip body; The cleaning inlet channel is used for cleaning the reaction chamber with the cleaning liquid flowing in from the cleaning inlet; The cleaning outlet channel is used for allowing the cleaning liquid in the reaction chamber to flow out from the cleaning outlet.

7. The microfluidic chip according to claim 6, characterized in that: An air channel connected to the reaction chamber is also formed in the chip body; The air channel is used to supply air to enter the reaction chamber from the air inlet after the reaction chamber is cleaned, so as to discharge the liquid in the reaction chamber.

8. A urine detection method, characterized in that: The microfluidic chip applied to any one of claims 1 to 7, the method comprising: When a detection instruction is received, the corresponding reagent hole is controlled to open by the solenoid valve in the microfluidic chip, and the detection reagent in the reagent capsule installed on the opened reagent hole flows into the reaction chamber through the corresponding reagent channel, and urine flows into the reaction chamber through the urine channel, and the reagent flowing into the reaction chamber reacts with the urine; The optical detection module performs optical detection on the mixed liquid after the urine and the detection reagent react in the reaction chamber to obtain detection data.

9. A urine analysis device, characterized in that: A microfluidic chip comprising any one of claims 1 to 7, a plurality of reagent capsules and a processor, wherein the plurality of reagent capsules are respectively mounted on reagent holes of the microfluidic chip, and the processor is connected to an optical detection module and a solenoid valve in the microfluidic chip; The processor is used to control the corresponding reagent hole to open through the solenoid valve in the microfluidic chip when urine flows in, so that the detection reagent in the reagent capsule installed on the reagent hole flows into the reaction chamber through the corresponding reagent channel, and controls urine to flow into the reaction chamber through the urine channel, so that the detection reagent flowing into the reaction chamber reacts with the urine; The processor is also used to use the optical detection module to perform optical detection on the mixed liquid after the urine and the detection reagent react in the reaction chamber to obtain detection data.

10. A toilet, characterized in that: The urine analysis device according to claim 9 is installed on the inner wall of the toilet.

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