A chromatographic column pipeline processing device and method capable of standardized operation

Abstract

The invention provides a chromatographic column pipeline processing device and method capable of standardized operation, belonging to the technical field of chromatographic column pipeline processing equipment. The chromatographic column pipeline processing device capable of standardized operation comprises a workbench, a pushing device, a clamping device, a cutting device and a grinding device; the pushing device is arranged on the workbench, and the pushing device comprises a side plate, two first pushing shafts, a first transmission belt, two second pushing shafts and a first motor; wherein, the side plate is provided with two first pushing shafts and two second pushing shafts penetrating therethrough, and the two first pushing shafts and the two second pushing shafts are respectively fixedly connected with a first pushing wheel and a second pushing wheel at one end located on the front side of the side plate, and a brake member is arranged, and a second air cylinder is controlled by a controller to be energized and extended, so as to push a brake rod to make an arc motion, so as to brake the brake member.

Description

Technical Field

[0001] The invention belongs to the technical field of chromatographic column pipeline processing equipment, and in particular relates to a chromatographic column pipeline processing device and method capable of standardized operation. Background Art

[0002] At present, liquid chromatography technology is a form of rapid preparative column chromatography, which is based on the use of a pump to generate pressure to accelerate the elution rate of the mobile phase through a prefilled chromatographic separation column. Its core component is the liquid chromatography column, and its separation principle is: dissolve the mixture sample in a mobile phase and make it pass through the stationary phase adsorbent filled in the liquid chromatography column at a certain rate. Since the solubility of the components of the mixture in the stationary phase and the mobile phase is different, that is, the distribution coefficient between the two phases is different, the components of the mixture will flow through the stationary phase adsorbent at different rates, thereby achieving the purpose of separation.

[0003] Existing chromatographic column tubes are usually polished manually, but the manual smoothness is not high enough, and the labor cost is increased. In addition, the polishing effect of the polishing equipment on the column tube is not ideal. Many impurities will be generated on the inner wall of the column tube when it is filled, so manual repetitive polishing is required, which increases the labor intensity and makes it difficult to achieve standardized operations. Summary of the invention

[0004] The embodiment of the present invention provides a chromatographic column pipeline processing device and method that can perform standardized operations, which aims to solve the problem that the existing chromatographic column tube is manually polished, the polishing effect of the polishing equipment on the column tube is not ideal, and manual repeated polishing is required.

[0005] In view of the above problems, the technical solution proposed by the present invention is:

[0006] A chromatographic column pipeline processing device capable of standardized operation, comprising:

[0007] Workbench;

[0008] A pushing device, the pushing device is arranged on the workbench, and the pushing device comprises a side plate, two first pushing shafts, a first transmission belt, two second pushing shafts and a first motor;

[0009] wherein, the side plate is provided with two first pushing shafts and two second pushing shafts penetrating therethrough, and the ends of the two first pushing shafts and the two second pushing shafts located at the front side of the side plate are fixedly connected with the first pushing wheel and the second pushing wheel respectively, the ends of the two first pushing shafts located at the rear side of the side plate are respectively sleeved with the first gear and the first rotating wheel, and the two first rotating wheels are rotatably connected through the first transmission belt, the ends of the two second pushing shafts located at the rear side of the side plate are sleeved with the second gear, the two first gears are meshedly connected with the two second gears, and the output end of the first motor is fixedly connected with one end of the one of the second pushing shafts located at the rear side of the side plate;

[0010] A clamping device, the clamping device is located on the right side of the pushing device, and the clamping device includes a mounting plate, a first guide rail, a first slider, a first clamping seat, a second clamping seat and a first cylinder;

[0011] Wherein, the mounting plate is arranged in an L shape, the number of the first guide rails is two, and the mounting plate and the two first guide rails are fixedly connected to the workbench, two first sliders are slidably connected to the two first guide rails along the length direction of the workbench, and the first clamping seat is fixedly connected between the two first sliders close to the width direction of the workbench, and the two first clamping seats are provided with second clamping seats that move toward or away from each other, the number of the first cylinders is two, the two first cylinders are slidably connected to the mounting plate, and the output ends of the two first cylinders are fixedly connected to the second clamping seat;

[0012] A cutting device, the cutting device is located between the two first cylinders, the cutting device comprises a second guide rail, a first slide plate, a third guide rail, a lifting assembly and a cutting machine;

[0013] There are two second guide rails, the first slide plate is slidably connected to the two second guide rails, the first slide plate is further provided with the third guide rail, the third guide rail is provided with the lifting assembly, and the lifting assembly is provided with the cutting machine;

[0014] A grinding device, which is arranged on the right side of the clamping device, and comprises a housing, a rotating sleeve, a coarse grinding cylinder, a fine grinding cylinder, a reversing assembly, a transmission assembly and a brake;

[0015] Wherein, the shell is fixedly connected to the workbench, and the shell has a protrusion, and a through hole is opened in the protrusion, and the rotating sleeve is embedded in the through hole, and one end of the rotating sleeve passes through the through hole, and the rotating sleeve has the rough grinding cylinder and the fine grinding cylinder penetrating therein, and the surfaces of the rough grinding cylinder and the fine grinding cylinder are respectively provided with a fourth gear and a fifth gear, the reversing assembly is connected to the rotating sleeve, and the transmission assembly is used to drive the fourth gear or the fifth gear respectively, so that the rough grinding cylinder and the fine grinding cylinder perform rough grinding and fine grinding, and the brake is used to prevent the transmission assembly from transmitting, so that the rough grinding cylinder or the fine grinding cylinder can be reversed.

[0016] As a preferred technical solution of the present invention, the lifting assembly includes a second slide, a rack, a support plate, a second motor and a third gear. The second slide is slidably connected to the third guide rail, the rack is provided on one side of the second slide, the side of the second slide close to the rack is fixedly connected to the support plate, the second motor is fixedly mounted on the support plate, the output end of the second motor is fixedly connected to the third gear, and the third gear is meshed with the rack.

[0017] As a preferred technical solution of the present invention, the coarse grinding cylinder has a first grinding chamber, a first grinding rod is arranged in the first grinding chamber, and the fine grinding cylinder has a second grinding chamber, a second grinding rod is arranged in the second grinding chamber.

[0018] As a preferred technical solution of the present invention, the wall surface of the first grinding chamber opposite to the first grinding rod is provided with a coarse grinding sheet, and the wall surface of the second grinding chamber opposite to the second grinding rod is provided with a fine grinding sheet.

[0019] As a preferred technical solution of the present invention, the reversing assembly includes a second wheel, a second transmission belt, a third motor and a third wheel. The second wheel is sleeved on the surface of the rotating sleeve, the third motor is fixedly installed on the bottom of the workbench top plate, and the output end of the third motor is sleeved with the third wheel. The second wheel and the third wheel are rotatably connected by a second transmission belt.

[0020] As a preferred technical solution of the present invention, the transmission assembly includes a fourth motor, a transmission shaft, a fourth wheel, an input shaft, a fifth wheel, a third transmission belt, a brake, an output shaft and a sixth gear. The fourth motor is fixedly installed on the top of the shell, and the output end of the fourth motor is fixedly connected to the transmission shaft, and the surface of the transmission shaft is sleeved with the fourth wheel. The input shaft is located below the fourth wheel and is rotatably connected to the side wall of the shell through a bearing seat. The surface of the input shaft is sleeved with the fifth wheel, and the fourth wheel and the fifth wheel are rotatably connected through the third transmission belt. One end of the input shaft is connected to the brake, and the brake is also connected to the output shaft. One end of the output shaft is sleeved with the sixth gear.

[0021] As a preferred technical solution of the present invention, the brake component includes a flywheel, an elastic cover, a friction disc, a pad, a return spring, a push rod, a connecting pipe and a brake disc, one end of the input shaft is inserted in the axis of the flywheel and fixedly connected to the flywheel, the other side of the flywheel is fixedly connected to the elastic cover, one end of the output end passes through the elastic cover and is inserted in the axis of the flywheel and fixedly connected to the flywheel, the end of the output shaft located in the elastic cover is respectively sleeved with the friction disc and the pad, the friction disc is fixedly connected to the pad, between the pad and the elastic cover and with the output shaft as the center of symmetry, two return springs are symmetrically arranged, two push rods are also arranged between the two return springs, one side of the elastic cover is fixedly connected to the connecting pipe, the connecting pipe is sleeved on the surface of the output shaft, and the surface of the connecting pipe is sleeved with the brake disc.

[0022] As a preferred technical solution of the present invention, the brake member includes a second cylinder and a brake rod, the second cylinder is fixedly mounted on a side wall of the shell, the output end of the second cylinder is rotatably connected to the brake rod, and the brake rod is rotatably connected to the shell through a rotating shaft.

[0023] As a preferred technical solution of the present invention, the coarse grinding cylinder or the fine grinding cylinder and the axis between the two first clamping seats and the two second clamping seats, the midpoint between the two second pushing wheels and the midpoint between the two first pushing wheels are all kept on the same straight line.

[0024] On the other hand, the present invention provides a method for processing a chromatographic column pipeline processing device capable of standardized operation, comprising the following steps:

[0025] S1, the second clamping seat and the first clamping seat are opened: the two first cylinders are controlled by the controller to be energized and contracted, so that the two first cylinders drive the two second clamping seats to move away from the two first clamping seats, so that the two second clamping seats can be separated from the two first clamping seats and the column tube installation space is reserved;

[0026] S2, installing the column tube: sequentially passing the column tube through the two first pushing wheels and the two second pushing wheels and the two column tube installation spaces, and inserting the column tube into the first grinding cavity, and inserting the first grinding rod into the column hole of the column tube;

[0027] S3, column tube cutting: according to the marked length marking line, the controller controls the second motor to energize and drive the third gear to rotate. Under the action of the rack, the second slide moves downward along the third guide rail, and the controller controls the cutting machine to cut the column tube;

[0028] S4, initial grinding and polishing of the column tube: the controller controls the fourth motor to be powered on to drive the transmission shaft and the fourth rotating wheel to rotate, and under the kinetic energy transmission of the third transmission belt, the fifth rotating wheel drives the input shaft, the brake output shaft and the sixth gear to rotate, and under the transmission of the sixth gear, the fourth gear follows the rotation and drives the rough grinding cylinder to perform initial grinding and polishing on the inner and outer surfaces of the column tube;

[0029] S5, reversing of fine grinding cylinder: the controller controls the second cylinder to be energized and extended, pushing the brake rod to make an arc movement, and the brake rod pushes the brake disc and the connecting pipe to compress the elastic cover, causing the return spring inside to be compressed, and the push rod pushes the pad and the friction disc to apply friction to the flywheel, so that the flywheel stops outputting power to the output shaft, and at the same time the controller controls the third motor to be energized to drive the third rotating wheel to rotate, and under the transmission action of the second transmission belt, the second rotating wheel drives the rotating sleeve to rotate so that the rough grinding cylinder and the fine grinding cylinder can be replaced, so that the fifth gear and the sixth gear are meshed, and after completion, the second cylinder contracts, the elastic cover and the return spring are reset successively, then the connecting pipe, the brake disc, the pad and the friction disc are also reset, and the flywheel resumes transmission to the output shaft;

[0030] S6, secondary grinding and polishing of the column tube: when the fine grinding cylinder reaches the position of the coarse grinding cylinder; the column tube is polished again using the method of step S4;

[0031] S7, replacing the end of the column tube: after the column tube is polished, the controller controls the first cylinder close to the polishing device to make the second clamping seat move away from the first clamping seat again, and at the same time, the coarse polishing cylinder and the fine polishing cylinder are replaced again. The operator replaces the other end of the column tube and inserts it into the first polishing chamber, and polishes the other end of the column tube using the method of steps S4 to S6;

[0032] S8, column tube pushing: after the above-mentioned column tube grinding is completed, the two first cylinders are controlled by the controller to make the two second clamping seats move away from each other again relative to the two first clamping seats, and the operator takes out the polished column tube, and controls the first motor to be energized by the controller to drive its second gear and its second pushing shaft to rotate, and the second gear and its first gear are meshed with each other, and the first gear and the second pushing shaft and its second gear and its second pushing shaft rotate in different directions, and at the same time, the second pushing shaft also drives the first rotating wheel on its surface to follow the rotation, and the other first gear is driven by the first transmission belt to follow the rotation of the first gear, and the other first gear and the other second gear are meshed with each other, so that the other second gear and the other first gear rotate in different directions, and the other second gear and the second gear rotate in the same direction, so that the two first pushing wheels and the two second pushing wheels can push the unpolished column tube and insert it into the first grinding cavity, and repeat steps S2 to S7 to grind and polish the unfinished column tube.

[0033] Compared with the prior art, the beneficial effects of the present invention are:

[0034] (1) Through the setting of the pushing device, the controller controls the first motor to be energized to drive the second gear and the second pushing shaft to rotate, and the second gear and the first gear are meshed with each other, so that the first gear and the second pushing shaft and the second gear and the second pushing shaft rotate in different directions. At the same time, the second pushing shaft also drives the first rotating wheel on its surface to follow the rotation, and the first transmission belt drives the other first gear to follow the rotation of the first gear. Through the meshing of the other first gear and the other second gear, the other second gear and the second gear rotate in different directions, and the other second gear and the second gear rotate in the same direction. Therefore, the two first pushing wheels and the two second pushing wheels can rotate in the same direction, and the two first pushing wheels and the two second pushing wheels that are longitudinally opposite to each other rotate in different directions, thereby ensuring the transportation of the column tube.

[0035] (2) The column tube is gradually polished by using the coarse polishing cylinder and the fine polishing cylinder in two different polishing methods, thereby improving the smoothness of the inner and outer surfaces of the column tube.

[0036] (3) Through the provided reversing assembly, the controller controls the third motor to be powered on to drive the third rotating wheel to rotate. Through the transmission action of the second transmission belt, the second rotating wheel drives the rotating sleeve to rotate so that the coarse grinding cylinder and the fine grinding cylinder can be replaced.

[0037] (4) The brake member is provided to push the brake disc and the connecting pipe to compress the elastic cover, causing the return spring inside the elastic cover to be compressed, and the push rod pushes the pad and the friction disc to apply friction to the flywheel, so that the flywheel stops outputting power to the output shaft.

[0038] (5) By setting the brake member, the controller controls the second cylinder to be energized and extended, pushing the brake rod to make an arc movement, thereby braking the brake member.

[0039] The above description is only an overview of the technical solution of the present invention. In order to more clearly understand the technical means of the present invention, it can be implemented according to the contents of the specification. In order to make the above and other purposes, features and advantages of the present invention more obvious and easy to understand, the specific implementation methods of the present invention are listed below. BRIEF DESCRIPTION OF THE DRAWINGS

[0040] Figure 1 It is a structural schematic diagram of a chromatographic column pipeline processing device capable of standardized operation disclosed in the present invention;

[0041] Figure 2 It is a top view of a pushing device of a chromatographic column pipeline processing device capable of standardized operation disclosed in the present invention;

[0042] Figure 3 It is a side view of a pushing device of a chromatographic column pipeline processing device capable of standardized operation disclosed in the present invention;

[0043] Figure 4 It is a side view of a clamping device of a chromatographic column pipeline processing device capable of standardized operation disclosed in the present invention;

[0044] Figure 5 yes Figure 4 A partial enlarged view of the middle part;

[0045] Figure 6 It is a shell cross-sectional view of a chromatographic column pipeline processing device capable of standardized operation disclosed in the present invention;

[0046] Figure 7 It is a side view of a shell of a chromatographic column pipeline processing device capable of standardized operation disclosed in the present invention;

[0047] Figure 8 It is a schematic diagram of the brake structure of a chromatographic column pipeline processing device capable of standardized operation disclosed in the present invention;

[0048] Fig. 9 It is a communication connection diagram of a chromatographic column pipeline processing device capable of standardized operation disclosed in the present invention;

[0049] Fig.10 The invention discloses a workflow diagram of a processing method for a chromatographic column pipeline processing device capable of standardized operations.

[0050] Description of the accompanying drawings: 100, workbench; 200, pushing device; 210, side plate; 220, first pushing shaft; 221, first pushing wheel; 222, first gear; 233, first rotating wheel; 230, first transmission belt; 240, second pushing shaft; 241, second pushing wheel; 242, second gear; 250, first motor; 300, clamping device; 310, mounting plate; 320, first guide rail; 330, first slider; 340, first A clamping seat; 350, a second clamping seat; 360, a first cylinder; 400, a cutting device; 410, a second guide rail; 420, a first slide; 430, a third guide rail; 440, a lifting assembly; 441, a second slide; 442, a rack; 443, a support plate; 444, a second motor; 445, a third gear; 450, a cutting machine; 500, a grinding device; 510, a housing; 511, a protrusion; 512, a through hole; 520, a rotating sleeve Cylinder; 530, coarse grinding cylinder; 531, fourth gear; 532, first grinding chamber; 533, first grinding rod; 540, fine grinding cylinder; 541, fifth gear; 542, second grinding chamber; 543, second grinding rod; 550, reversing assembly; 551, second rotating wheel; 552, second transmission belt; 553, third motor; 554, third rotating wheel; 560, transmission assembly; 561, fourth motor; 562, transmission shaft; 563, fourth rotating wheel wheel; 564, input shaft; 565, fifth rotating wheel; 566, third transmission belt; 567, brake member; 5571, flywheel; 5572, elastic cover; 5573, friction disc; 5574, pad; 5575, return spring; 5576, push rod; 5577, connecting pipe; 5578, brake disc; 568, output shaft; 569, sixth gear; 570, brake member; 571, second cylinder; 572, brake rod; 600, controller. DETAILED DESCRIPTION

[0051] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0052] Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the invention claimed for protection, but merely represents selected embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0053] It should be noted that similar reference numerals and letters denote similar items in the following drawings, and therefore, once an item is defined in one drawing, further definition and explanation thereof is not required in subsequent drawings.

[0054] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present invention.

[0055] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include one or more of the features. In the description of the present invention, the meaning of "plurality" is two or more, unless otherwise clearly and specifically defined.

[0056] Embodiment 1

[0057] See attached Figures 1 to 9 As shown, the present invention provides a technical solution: a chromatographic column pipeline processing device capable of standardized operation, comprising a workbench 100, a pushing device 200, a clamping device 300, a cutting device 400 and a polishing device 500;

[0058] See attached Figures 1 to 3 As shown, the pushing device 200 is arranged on the workbench 100, and the pushing device 200 includes a side plate 210, two first pushing shafts 220, a first transmission belt 230, two second pushing shafts 240 and a first motor 250; wherein, the side plate 210 is provided with two first pushing shafts 220 and two second pushing shafts 240 penetrating therethrough, and one end of the two first pushing shafts 220 and the two second pushing shafts 240 located at the front side of the side plate 210 is fixedly connected with a first pushing wheel 221 and a second pushing wheel 242, respectively. 1. The first gear 222 and the first rotating wheel 233 are respectively sleeved on one end of the two first pushing shafts 220 located at the rear side of the side plate 210, and the two first rotating wheels 233 are rotatably connected through the first transmission belt 230. The second gear 242 is sleeved on one end of the two second pushing shafts 240 located at the rear side of the side plate 210, and the two first gears 222 are meshed with the two second gears 242. The output end of the first motor 250 is fixedly connected to one end of the second pushing shaft 240 located at the rear side of the side plate 210.

[0059] In the embodiment, the controller 600 controls the first motor 250 to be energized to drive the second gear 242 and the second push shaft 240 to rotate, and the second gear 242 is meshed with the first gear 222, and the first gear 222 and the second push shaft 240 and the second gear 242 and the second push shaft 240 rotate in different directions. At the same time, the second push shaft 240 also drives the first rotating wheel 233 on its surface to follow the rotation, and the other first gear 222 is rotated following the first gear 222 through the transmission of the first transmission belt 230. The other first gear 222 and the other second gear 242 are meshed with each other, so that the other second gear 242 and the other first gear 222 rotate in different directions, and the other second gear 242 and the second gear 242 rotate in the same direction.

[0060] That is to say, the first motor 250 drives the second pushing shaft 240, the second gear 242 and the second pushing wheel 241 to rotate clockwise. Then, under the tooth meshing cooperation between the second gear 242 and the first gear 222, the first gear 222, the first rotating wheel 233, the first pushing shaft 220 and the first pushing wheel 221 all rotate counterclockwise, and under the transmission of the first transmission belt 230, the first rotating wheel 233, the first gear 222, the first pushing shaft 220 and the first pushing wheel 221 away from the first motor 250 follow the counterclockwise rotation. Then, under the tooth meshing cooperation between the first gear 222 and the second gear 242 away from the first motor 250, the second gear 242, the second pushing shaft 240 and the second pushing wheel 241 all rotate clockwise, so that the two first pushing wheels 221 and the two second pushing wheels 241 can rotate in the same direction, and the two first pushing wheels and the two second pushing wheels 241 opposite to each other in the longitudinal direction rotate in different directions, thereby ensuring the transportation of the column tube.

[0061] See attached Figure 1 and 4 As shown, the clamping device 300 is located on the right side of the pushing device 200, and the clamping device 300 includes a mounting plate 310, a first guide rail 320, a first slider 330, a first clamping seat 340, a second clamping seat 350 and a first cylinder 360; wherein, the mounting plate 310 is arranged in an L shape, the number of the first guide rails 320 is two, and the mounting plate 310 and the two first guide rails 320 are fixedly connected to the workbench 100, and the two first sliders 330 are slidably connected to the two first guide rails 320 along the length direction of the workbench 100, and the first clamping seat 340 is fixedly connected between the two first sliders 330 close to the width direction of the workbench 100, and the two first clamping seats 340 are provided with second clamping seats 350 that can move toward or away from each other, and the number of the first cylinders 360 is two, and the two first cylinders 360 are slidably connected to the mounting plate 310, and the output ends of the two first cylinders 360 are fixedly connected to the second clamping seat 350.

[0062] In this embodiment, the clamping device 300 mainly plays a fixing role during the cutting and grinding and polishing process. When placing the column tube, the controller 600 controls the two first cylinders 360 to be energized and contracted, so that the two first cylinders 360 drive the two second clamping seats 350 to move away from the two first clamping seats 340, and the two second clamping seats 350 can be separated from the two first clamping seats 340 and reserve column tube installation space. After completion, the controller 600 controls the two first cylinders 360 to be energized and extended, so that the two first cylinders 360 drive the two second clamping seats 350 to move toward each other relative to the two first clamping seats 340, so that the two second clamping seats 350 and the first clamping seats 340 form a closed state.

[0063] Furthermore, during the grinding and polishing process, the first clamping seat 340 and the second clamping seat 350 close to the rough grinding cylinder 530 clamp one-third of the length of the column tube, leaving two-thirds of the length for grinding by the grinding device 500. After grinding two-thirds of the length of the column tube, the operator needs to switch to one-third of the length of the column tube for grinding.

[0064] In another embodiment, the mounting plate 310 is located at the sliding portion of the two first cylinders 360, and a slideway (not shown) is provided inside the mounting plate 310 for the two first cylinders 360 to slide, which is mainly used for adjusting the length of column tubes of different specifications.

[0065] In another embodiment, the two first clamping seats 340 can move along the first guide rail 320 according to the specifications of the column tube, and in order to ensure the two first clamping seats 340 are limited in position, the two first clamping seats 340 and the first guide rail 320 are fixed by positioning pins.

[0066] See attached Figure 1 and 5 As shown, the cutting device 400 is located between the two first cylinders 360, and the cutting device 400 includes a second guide rail 410, a first slide plate 420, a third guide rail 430, a lifting assembly 440 and a cutting machine 450; wherein, the number of the second guide rails 410 is two, the first slide plate 420 is slidably connected to the two second guide rails 410, the first slide plate 420 is also provided with a third guide rail 430, the third guide rail 430 is provided with a lifting assembly 440, and the lifting assembly 440 is provided with a cutting machine 450.

[0067] In this embodiment, when cutting, the lifting assembly 440 moves downward along the third guide rail 430, and the controller 600 controls the cutting machine 450 to be powered on to cut the column tube.

[0068] In another embodiment, the lifting assembly 440 includes a second slide 441, a rack 442, a support plate 443, a second motor 444 and a third gear 445. The second slide 441 is slidably connected to the third guide rail 430. A rack 442 is provided on one side of the second slide 441. The side of the second slide 441 close to the rack 442 is fixedly connected to the support plate 443. The second motor 444 is fixedly installed on the support plate 443. The output end of the second motor 444 is fixedly connected to the third gear 445, and the third gear 445 is meshed with the rack 442.

[0069] Specifically, the controller 600 controls the second motor 444 to be powered on to drive the third gear 445 to rotate, and under the action of the rack 442 , the second slide plate 441 can move downward along the third guide rail 430 .

[0070] See attached Figure 1 , 6 As shown in Figure 8, the grinding device 500 is arranged on the right side of the clamping device 300, and the grinding device 500 includes a housing 510, a rotating sleeve 520, a coarse grinding cylinder 530, a fine grinding cylinder 540, a reversing assembly 550, a transmission assembly 560 and a brake member 570; wherein the housing 510 is fixedly connected to the workbench 100, and a protrusion 511 is provided in the housing 510, and a through hole 512 is provided in the protrusion 511, and a rotating sleeve 520 is embedded in the through hole 512, and one end of the rotating sleeve 520 passes through the through hole 512, and the rotating sleeve The barrel 520 has a coarse grinding barrel 530 and a fine grinding barrel 540 penetrating therein, and the surfaces of the coarse grinding barrel 530 and the fine grinding barrel 540 are respectively sleeved with a fourth gear 531 and a fifth gear 541, the reversing assembly 550 is connected to the rotating sleeve 520, and the transmission assembly 560 is used to drive the fourth gear 531 or the fifth gear 541 respectively, so that the coarse grinding barrel 530 and the fine grinding barrel 540 perform coarse grinding and fine grinding, and the brake 570 is used to prevent the transmission assembly 560 from transmitting, so that the coarse grinding barrel 530 or the fine grinding barrel 540 can be reversed.

[0071] The coarse grinding cylinder 530 has a first grinding chamber 532, in which a first grinding rod 533 is disposed, and the fine grinding cylinder 540 has a second grinding chamber 542, in which a second grinding rod 543 is disposed. The wall surface of the first grinding chamber 532 opposite to the first grinding rod 533 is provided with a coarse grinding sheet, and the wall surface of the second grinding chamber 542 opposite to the second grinding rod 543 is provided with a fine grinding sheet.

[0072] The reversing assembly 550 includes a second rotating wheel 551, a second transmission belt 552, a third motor 553 and a third rotating wheel 554. The second rotating wheel 551 is sleeved on the surface of the rotating sleeve 520. The third motor 553 is fixedly installed on the bottom of the top plate of the workbench 100. The output end of the third motor 553 is sleeved with the third rotating wheel 554. The second rotating wheel 551 and the third rotating wheel 554 are rotatably connected through the second transmission belt 552.

[0073] Specifically, the controller 600 controls the third motor 553 to be powered on to drive the third rotating wheel 554 to rotate. Through the transmission action of the second transmission belt 552, the second rotating wheel 551 drives the rotating sleeve 520 to rotate so that the coarse grinding cylinder 530 and the fine grinding cylinder 540 can be replaced.

[0074] The transmission assembly 560 includes a fourth motor 561, a transmission shaft 562, a fourth rotating wheel 563, an input shaft 564, a fifth rotating wheel 565, a third transmission belt 566, a brake 570, an output shaft 568 and a sixth gear 569. The fourth motor 561 is fixedly installed on the top of the housing 510. The output end of the fourth motor 561 is fixedly connected with the transmission shaft 562. The surface of the transmission shaft 562 is sleeved with the fourth rotating wheel 563. The input shaft 564 is located below the fourth rotating wheel 563 and is rotatably connected to the side wall of the housing 510 through a bearing seat. The surface of the input shaft 564 is sleeved with the fifth rotating wheel 565. The fourth rotating wheel 563 and the fifth rotating wheel 565 are rotatably connected through the third transmission belt 566. One end of the input shaft 564 is connected with the brake 570. The brake 570 is also connected with the output shaft 568. One end of the output shaft 568 is sleeved with the sixth gear 569.

[0075] Specifically, the controller 600 controls the fourth motor 561 to be powered on to drive the transmission shaft 562 and the fourth wheel 563 to rotate. Under the kinetic energy transmission of the third transmission belt 566, the fifth wheel 565 drives the input shaft 564, the brake 570, the output shaft 568 and the sixth gear 569 to rotate. Under the transmission of the sixth gear 569, the fourth gear 531 follows the rotation and drives the rough grinding cylinder 530 to grind and polish the inner and outer surfaces of the column tube.

[0076] The brake member 570 includes a flywheel 5571, an elastic cover 5572, a friction disc 5573, a pad 5574, a return spring 5575, a push rod 5576, a connecting pipe 5577 and a brake disc 5578. One end of the input shaft 564 is inserted into the axis of the flywheel 5571 and is fixedly connected to the flywheel 5571. The other side of the flywheel 5571 is fixedly connected to the elastic cover 5572. One end of the output end passes through the elastic cover 5572 and is inserted into the axis of the flywheel 5571 and is fixedly connected to the flywheel 5571. The output shaft 568 is located at the elastic cover 5 One end of 572 is respectively sleeved with a friction disk 5573 and a pad 5574, the friction disk 5573 is fixedly connected to the pad 5574, two return springs 5575 are symmetrically arranged between the pad 5574 and the elastic cover 5572 and with the output shaft 568 as the symmetry center, and two push rods 5576 are also arranged between the two return springs 5575, and one side of the elastic cover 5572 is fixedly connected with a connecting pipe 5577, the connecting pipe 5577 is sleeved on the surface of the output shaft 568, and the surface of the connecting pipe 5577 is sleeved with a brake disk 5578.

[0077] Specifically, the brake member 570 pushes the brake disc 5578 and the connecting tube 5577 to compress the elastic cover 5572, causing the return spring 5575 inside it to be compressed, and the push rod 5576 pushes the pad 5574 and the friction disc 5573 to apply friction force to the flywheel 5571, so that the flywheel 5571 stops outputting power to the output shaft 568.

[0078] The brake member 570 includes a second cylinder 571 and a brake rod 572. The second cylinder 571 is fixedly mounted on a side wall of the housing 510. The output end of the second cylinder 571 is rotatably connected to the brake rod 572. The brake rod 572 is rotatably connected to the housing 510 via a rotating shaft.

[0079] Specifically, the controller 600 controls the second cylinder 571 to be energized and extended, thereby pushing the brake rod 572 to make an arc motion, thereby braking the brake member 570 .

[0080] In the embodiment of the present invention, the coarse grinding cylinder 530 or the fine grinding cylinder 540 and the axis between the two first clamping seats 340 and the two second clamping seats 350, the midpoint between the two second pushing wheels 241 and the midpoint between the two first pushing wheels 221 are all kept on the same straight line.

[0081] In an embodiment of the present invention, a controller 600 is also installed on one side of the workbench 100, and the first motor 250, the first cylinder 360, the second motor 444, the cutting machine 450, the third motor 553, the fourth motor 561 and the second cylinder 571 are all communicatively connected to the controller 600.

[0082] Embodiment 2

[0083] See attached Fig.10 As shown, an embodiment of the present invention further provides a processing method for a chromatographic column pipeline processing device capable of standardized operation, comprising the following steps:

[0084] S1, the second clamping seat and the first clamping seat are opened: the two first cylinders 360 are controlled by the controller 600 to be energized and contracted, so that the two first cylinders 360 drive the two second clamping seats 350 to move away from the two first clamping seats 340, so that the two second clamping seats 350 can be separated from the two first clamping seats 340 and a column tube installation space is reserved;

[0085] S2, installing the column tube: sequentially passing the column tube through the two first pushing wheels 221 and the two second pushing wheels 241 and the two column tube installation spaces, and inserting the column tube into the first polishing cavity 532, while the first polishing rod 533 is inserted into the column hole of the column tube;

[0086] S3, column tube cutting: according to the marked length marking line, the controller 600 controls the second motor 444 to energize and drive the third gear 445 to rotate. Under the action of the rack 442, the second slide 441 moves downward along the third guide rail 430. At the same time, the controller 600 controls the cutting machine 450 to cut the column tube;

[0087] S4, initial grinding and polishing of the column tube: the controller 600 controls the fourth motor 561 to be powered on to drive the transmission shaft 562 and the fourth rotating wheel 563 to rotate. Under the kinetic energy transmission of the third transmission belt 566, the fifth rotating wheel 565 drives the input shaft 564, the output shaft 568 of the brake member 570 and the sixth gear 569 to rotate. Under the transmission of the sixth gear 569, the fourth gear 531 rotates accordingly and drives the rough grinding cylinder 530 to perform initial grinding and polishing on the inner and outer surfaces of the column tube.

[0088] S5, fine grinding cylinder reversing: the controller 600 controls the second cylinder 571 to be energized and extended, pushing the brake rod 572 to make an arc movement, and the brake rod 572 pushes the brake disc 5578 and the connecting pipe 5577 to compress the elastic cover 5572, causing the return spring 5575 inside to be compressed, and the push rod 5576 pushes the pad 5574 and the friction disc 5573 to apply friction to the flywheel 5571, so that the flywheel 5571 stops outputting power to the output shaft 568, and at the same time the controller 600 controls the third motor 553 to be energized to drive the third motor 553 to be driven. The third rotating wheel 554 rotates, and under the transmission action of the second transmission belt 552, the second rotating wheel 551 drives the rotating sleeve 520 to rotate, so that the rough grinding cylinder 530 and the fine grinding cylinder 540 can be replaced, so that the fifth gear 541 and the sixth gear 569 are meshed. After completion, the second cylinder 571 contracts, the elastic cover 5572 and the return spring 5575 are successively returned, and the connecting pipe 5577, the brake disc 5578, the pad 5574 and the friction disc 5573 are also returned, and the flywheel 5571 resumes the transmission to the output shaft 568;

[0089] S6, secondary grinding and polishing of the column tube: when the fine grinding cylinder 540 reaches the position of the rough grinding cylinder 530, the column tube is polished again using the method of step S4;

[0090] S7, replace the end of the column tube: after the column tube is polished, the controller 600 controls the first cylinder 360 near the polishing device 500 to make the second clamping seat 350 move away from the first clamping seat 340 again, and at the same time, the coarse polishing cylinder 530 and the fine polishing cylinder 540 are replaced again. The operator replaces the other end of the column tube and inserts it into the first polishing cavity 532, and polishes the other end of the column tube using the method of steps S4 to S6;

[0091] S8, column tube pushing: After the column tube is polished, the controller 600 controls the two first cylinders 360 to make the two second clamping seats 350 move away from each other relative to the two first clamping seats 340 again. The operator takes out the polished column tube, and controls the first motor 250 to be powered on by the controller 600 to drive the second gear 242 and the second pushing shaft 240 to rotate, and the second gear 242 and the first gear 222 are meshed with each other, and the first gear 222 and the second pushing shaft 240 and the second gear 242 and the second pushing shaft 240 rotate in different directions, and the second pushing shaft 240 also drives the second pushing shaft 240 to rotate in different directions. The first rotating wheel 233 on the surface of the rotating wheel follows the rotation, and the first transmission belt 230 drives the other first gear 222 to follow the rotation of the other first gear 222. The other first gear 222 and the other second gear 242 are meshed with each other, so that the other second gear 242 and the other first gear 222 rotate in different directions, and the other second gear 242 and the other second gear 242 rotate in the same direction. Therefore, the two first pushing wheels 221 and the two second pushing wheels 241 can push the unpolished column tube and insert it into the first polishing chamber 532, and repeat steps S2 to S7 to polish the unfinished column tube.

[0092] It should be noted that the model specifications of the first motor 250, the first cylinder 360, the second motor 444, the cutting machine 450, the third motor 553, the fourth motor 561, the second cylinder 571 and the controller 600 need to be selected and determined according to the actual specifications of the device. The specific selection calculation method adopts the existing technology in the field, so it will not be described in detail.

[0093] The power supply and principles of the first motor 250, the first cylinder 360, the second motor 444, the cutting machine 450, the third motor 553, the fourth motor 561, the second cylinder 571 and the controller 600 are clear to those skilled in the art and will not be described in detail herein.

[0094] The above are only preferred embodiments of the present invention and are not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A chromatographic column pipeline processing device capable of standardized operation, characterized in that: include: Workbench; A pushing device, the pushing device is arranged on the workbench, and the pushing device comprises a side plate, two first pushing shafts, a first transmission belt, two second pushing shafts and a first motor; wherein, the side plate is provided with two first pushing shafts and two second pushing shafts penetrating therethrough, and the ends of the two first pushing shafts and the two second pushing shafts located at the front side of the side plate are fixedly connected with the first pushing wheel and the second pushing wheel respectively, the ends of the two first pushing shafts located at the rear side of the side plate are respectively sleeved with the first gear and the first rotating wheel, and the two first rotating wheels are rotatably connected through the first transmission belt, the ends of the two second pushing shafts located at the rear side of the side plate are sleeved with the second gear, the two first gears are meshedly connected with the two second gears, and the output end of the first motor is fixedly connected with one end of the one of the second pushing shafts located at the rear side of the side plate; A clamping device, the clamping device is located on the right side of the pushing device, and the clamping device includes a mounting plate, a first guide rail, a first slider, a first clamping seat, a second clamping seat and a first cylinder; Wherein, the mounting plate is arranged in an L shape, the number of the first guide rails is two, and the mounting plate and the two first guide rails are fixedly connected to the workbench, two first sliders are slidably connected to the two first guide rails along the length direction of the workbench, and the first clamping seat is fixedly connected between the two first sliders close to the width direction of the workbench, and the two first clamping seats are provided with second clamping seats that move toward or away from each other, the number of the first cylinders is two, the two first cylinders are slidably connected to the mounting plate, and the output ends of the two first cylinders are fixedly connected to the second clamping seat; A cutting device, the cutting device is located between the two first cylinders, the cutting device comprises a second guide rail, a first slide plate, a third guide rail, a lifting assembly and a cutting machine; There are two second guide rails, the first slide plate is slidably connected to the two second guide rails, the first slide plate is further provided with the third guide rail, the third guide rail is provided with the lifting assembly, and the lifting assembly is provided with the cutting machine; A grinding device, which is arranged on the right side of the clamping device, and comprises a housing, a rotating sleeve, a coarse grinding cylinder, a fine grinding cylinder, a reversing assembly, a transmission assembly and a brake; Wherein, the shell is fixedly connected to the workbench, and the shell has a protrusion, and a through hole is opened in the protrusion, and the rotating sleeve is embedded in the through hole, and one end of the rotating sleeve passes through the through hole, and the rotating sleeve has the rough grinding cylinder and the fine grinding cylinder penetrating therein, and the surfaces of the rough grinding cylinder and the fine grinding cylinder are respectively provided with a fourth gear and a fifth gear, the reversing assembly is connected to the rotating sleeve, and the transmission assembly is used to drive the fourth gear or the fifth gear respectively, so that the rough grinding cylinder and the fine grinding cylinder perform rough grinding and fine grinding, and the brake is used to prevent the transmission assembly from transmitting, so that the rough grinding cylinder or the fine grinding cylinder can be reversed.

2. A chromatographic column pipeline processing device capable of standardized operation according to claim 1, characterized in that: The lifting assembly includes a second slide, a rack, a support plate, a second motor and a third gear. The second slide is slidably connected to the third guide rail. The rack is provided on one side of the second slide. The support plate is fixedly connected to a side of the second slide close to the rack. The second motor is fixedly mounted on the support plate. The output end of the second motor is fixedly connected to the third gear, and the third gear is meshed with the rack.

3. A chromatographic column pipeline processing device capable of standardized operation according to claim 1, characterized in that: The coarse grinding cylinder has a first grinding chamber, in which a first grinding rod is arranged, and the fine grinding cylinder has a second grinding chamber, in which a second grinding rod is arranged.

4. A chromatographic column pipeline processing device capable of standardized operation according to claim 3, characterized in that: The wall surface of the first grinding chamber opposite to the first grinding rod is provided with a coarse grinding sheet, and the wall surface of the second grinding chamber opposite to the second grinding rod is provided with a fine grinding sheet.

5. A chromatographic column pipeline processing device capable of standardized operation according to claim 1, characterized in that: The reversing assembly includes a second rotating wheel, a second transmission belt, a third motor and a third rotating wheel. The second rotating wheel is sleeved on the surface of the rotating sleeve. The third motor is fixedly installed on the bottom of the workbench top plate. The output end of the third motor is sleeved with the third rotating wheel. The second rotating wheel and the third rotating wheel are rotatably connected by a second transmission belt.

6. A chromatographic column pipeline processing device capable of standardized operation according to claim 1, characterized in that: The transmission assembly includes a fourth motor, a transmission shaft, a fourth wheel, an input shaft, a fifth wheel, a third transmission belt, a brake, an output shaft and a sixth gear. The fourth motor is fixedly mounted on the top of the shell, the output end of the fourth motor is fixedly connected to the transmission shaft, the surface of the transmission shaft is sleeved with the fourth wheel, the input shaft is located below the fourth wheel and is rotatably connected to the side wall of the shell through a bearing seat, the surface of the input shaft is sleeved with the fifth wheel, the fourth wheel and the fifth wheel are rotatably connected through the third transmission belt, one end of the input shaft is connected to the brake, the brake is also connected to the output shaft, and one end of the output shaft is sleeved with the sixth gear.

7. A chromatographic column pipeline processing device capable of standardized operation according to claim 6, characterized in that: The brake component includes a flywheel, an elastic cover, a friction disc, a pad, a return spring, a push rod, a connecting pipe and a brake disc, one end of the input shaft is inserted in the axis of the flywheel and fixedly connected to the flywheel, the other side of the flywheel is fixedly connected to the elastic cover, one end of the output end passes through the elastic cover and is inserted in the axis of the flywheel and fixedly connected to the flywheel, one end of the output shaft located in the elastic cover is respectively sleeved with the friction disc and the pad, the friction disc is fixedly connected to the pad, two return springs are symmetrically arranged between the pad and the elastic cover and with the output shaft as the center of symmetry, two push rods are also arranged between the two return springs, one side of the elastic cover is fixedly connected to the connecting pipe, the connecting pipe is sleeved on the surface of the output shaft, and the surface of the connecting pipe is sleeved with the brake disc.

8. A chromatographic column pipeline processing device capable of standardized operation according to claim 7, characterized in that: The brake member comprises a second cylinder and a brake rod. The second cylinder is fixedly mounted on a side wall of the housing. The output end of the second cylinder is rotatably connected to the brake rod. The brake rod is rotatably connected to the housing via a rotating shaft.

9. The chromatographic column pipeline processing device capable of standardized operation according to claim 1, characterized in that: The coarse grinding cylinder or the fine grinding cylinder and the axis between the two first clamping seats and the two second clamping seats, the midpoint between the two second pushing wheels and the midpoint between the two first pushing wheels are all kept on the same straight line.

10. A method for processing a chromatographic column pipeline processing device capable of standardized operation, applied to a chromatographic column pipeline processing device capable of standardized operation as claimed in any one of claims 1 to 9, characterized in that: The following steps are involved: S1, the second clamping seat and the first clamping seat are opened: the two first cylinders are controlled by the controller to be energized and contracted, so that the two first cylinders drive the two second clamping seats to move away from the two first clamping seats, so that the two second clamping seats can be separated from the two first clamping seats and the column tube installation space is reserved; S2, installing the column tube: sequentially passing the column tube through the two first pushing wheels and the two second pushing wheels and the two column tube installation spaces, and inserting the column tube into the first grinding cavity, and inserting the first grinding rod into the column hole of the column tube; S3, column tube cutting: according to the marked length marking line, the controller controls the second motor to energize and drive the third gear to rotate. Under the action of the rack, the second slide moves downward along the third guide rail, and the controller controls the cutting machine to cut the column tube; S4, initial grinding and polishing of the column tube: the controller controls the fourth motor to be powered on to drive the transmission shaft and the fourth rotating wheel to rotate, and under the kinetic energy transmission of the third transmission belt, the fifth rotating wheel drives the input shaft, the brake output shaft and the sixth gear to rotate, and under the transmission of the sixth gear, the fourth gear follows the rotation and drives the rough grinding cylinder to perform initial grinding and polishing on the inner and outer surfaces of the column tube; S5, reversing of fine grinding cylinder: the controller controls the second cylinder to be energized and extended, pushing the brake rod to make an arc movement, and the brake rod pushes the brake disc and the connecting pipe to compress the elastic cover, causing the return spring inside to be compressed, and the push rod pushes the pad and the friction disc to apply friction to the flywheel, so that the flywheel stops outputting power to the output shaft, and at the same time the controller controls the third motor to be energized to drive the third rotating wheel to rotate, and under the transmission action of the second transmission belt, the second rotating wheel drives the rotating sleeve to rotate so that the rough grinding cylinder and the fine grinding cylinder can be replaced, so that the fifth gear and the sixth gear are meshed, and after completion, the second cylinder contracts, the elastic cover and the return spring are reset successively, then the connecting pipe, the brake disc, the pad and the friction disc are also reset, and the flywheel resumes transmission to the output shaft; S6, secondary grinding and polishing of the column tube: when the fine grinding cylinder reaches the position of the coarse grinding cylinder; the column tube is polished again using the method of step S4; S7, replacing the end of the column tube: after the column tube is polished, the controller controls the first cylinder close to the polishing device to make the second clamping seat move away from the first clamping seat again, and at the same time, the coarse polishing cylinder and the fine polishing cylinder are replaced again. The operator replaces the other end of the column tube and inserts it into the first polishing chamber, and polishes the other end of the column tube using the method of steps S4 to S6; S8, column tube pushing: after the above-mentioned column tube grinding is completed, the two first cylinders are controlled by the controller to make the two second clamping seats move away from each other again relative to the two first clamping seats, and the operator takes out the polished column tube, and controls the first motor to be energized by the controller to drive its second gear and its second pushing shaft to rotate, and the second gear and its first gear are meshed with each other, and the first gear and the second pushing shaft and its second gear and its second pushing shaft rotate in different directions, and at the same time, the second pushing shaft also drives the first rotating wheel on its surface to follow the rotation, and the other first gear is driven by the first transmission belt to follow the rotation of the first gear, and the other first gear and the other second gear are meshed with each other, so that the other second gear and the other first gear rotate in different directions, and the other second gear and the second gear rotate in the same direction, so that the two first pushing wheels and the two second pushing wheels can push the unpolished column tube and insert it into the first grinding cavity, and repeat steps S2 to S7 to grind and polish the unfinished column tube.

Images