Preparation method of anti-hepatoma drug stasis removing tablet

Abstract

The invention discloses a preparation method of an anti-hepatoma drug stasis removing tablet. The anti-hepatoma drug stasis removing tablet comprises rhizoma typhonii, cortex juglandis mandshuricae, cortex dictamni and calculus bovis factitious. The preparation method comprises the following steps: step 1, removing toxins in the rhizoma typhonii component, the cortex juglandis mandshuricae component and the cortex dictamni component in the stasis removing tablet to obtain non-toxic rhizoma typhonii, non-toxic cortex juglandis mandshuricae and non-toxic cortex dictamni powder; and 2, uniformly mixing the non-toxic rhizoma typhonii, the non-toxic cortex juglandis mandshuricae, the non-toxic cortex dictamni powder and the calculus bovis factitius obtained in the step 1, volatilizing a medium, performing granulating and drying, pressing into tablets, and coating with a film, thereby obtaining the anti-hepatoma drug stasis removing tablet. The beneficial effects are as follows: components in the formula of the stasis removing tablet are decomposed and converted through probiotics; toxic components in traditional Chinese medicines are thoroughly removed; the drug effect and the absorption effect are greatly improved; and the medication safety of clinical patients is improved.

Description

technical field

[0001] The invention relates to the technical field of biomedicine, in particular to a method for preparing an anti-liver cancer drug Sanjie Tablet. The product name is Sanjie Tablet. Background technique

[0002] The Chinese invention patent with the application number CN200410050749.3 discloses a traditional Chinese medicine for treating liver cancer and its preparation process. For the second time, the amount of water added for the first time is 12 times the total weight of the raw materials of the medicinal materials, decocted for 2 hours, the amount of water added for the second time is 8 times the total weight of the raw materials of the medicinal materials, decocted for 1 hour, filtered, and the combined filtrate is concentrated to a relative density 1.35 ~ 1.38, the temperature is 70 ℃ clear paste, dried under reduced pressure, crushed, added artificial bezoar fine powder and auxiliary materials, mixed, granulated with 75% ethanol, dried, pressed into...

Examples

preparation example Construction

[0044] A preparation method of anti-liver cancer drug Sanjie Tablets, comprising the Sanjie Tablets containing Radix Aconiti, Qinglongyi, Baixianpi, and artificial bezoar. The preparation method comprises the following steps:

[0045] Step 1, removing the toxins in the components of Aconite Radix, Qinglongyi, and Fresh Cortex in the Sanjie Tablets to obtain non-toxic Radix Aconiti, Qinglongyi, and Fresh Cortex powder;

[0046] Step 2: Mix the non-toxic Radix Aconiti, non-toxic Qinglongyi, non-toxic white fresh bark powder and artificial bezoar obtained in Step 1, granulate with volatile medium, dry, compress into tablets, and coat with film to obtain the product.

[0047] Further, the toxin in the Qinglongyi composition in the described removal Sanjie tablet comprises the steps:

[0048] Step 1, directly preparing the fresh Qinglongyi as Qinglongyi homogenate or pulverizing the fresh Qinglongyi dry product into Qinglongyi coarse powder;

[0049] Step 2: Take probiotics and mi...

Embodiment 1

[0075] Non-toxic Qinglongyi powder is made by the following method: Homogenize fresh Qinglongyi directly; take bifidobacteria and 35 ºC distilled water according to the volume ratio of 1:40 and mix them evenly to make bifidobacteria liquid. Bifidobacteria liquid OD600=0.63, then according to the ratio of adding 2800mL Bifidobacterium liquid to 1 kg of Qinglongyi homogenate, take the Bifidobacterium liquid and add it to Qinglongyi homogenate, mix well, and ferment at 30°C After culturing for 4 days, the aeration ratio is 2 (v / v), the stirring rate is 150r / min, and then the fermented Qinglongyi fermentation mixture is dried at 45ºC and crushed into fine powder, which is the avirulent bifidobacterium fermented Qinglong Clothing powder.

Embodiment 2

[0077] The toxins in the components of Qinglongyi are removed by the following method: crush the dried medicinal materials of Qinglongyi into a coarse powder; take Saccharomyces cerevisiae and 30 ºC distilled water in a volume ratio of 1:20 and mix them evenly to make a Saccharomyces cerevisiae liquid. Liquid OD600=0.81, and according to the ratio of adding 3000mL Saccharomyces cerevisiae liquid to 1 kg Qinglongyi coarse powder, take Saccharomyces cerevisiae liquid and add Qinglongyi coarse powder, mix evenly, ferment and cultivate at 36°C for 3 days, the aeration ratio 5 (v / v), stirring rate 200r / min, then dry the fermented Qinglongyi fermentation mixture at 55ºC, and grind it into a fine powder, which is non-toxic Saccharomyces cerevisiae fermented Qinglongyi powder.

technical field

[0001] The invention relates to the technical field of biomedicine, in particular to a method for preparing an anti-liver cancer drug Sanjie Tablet. The product name is Sanjie Tablet. Background technique

[0002] The Chinese invention patent with the application number CN200410050749.3 discloses a traditional Chinese medicine for treating liver cancer and its preparation process. For the second time, the amount of water added for the first time is 12 times the total weight of the raw materials of the medicinal materials, decocted for 2 hours, the amount of water added for the second time is 8 times the total weight of the raw materials of the medicinal materials, decocted for 1 hour, filtered, and the combined filtrate is concentrated to a relative density 1.35 ~ 1.38, the temperature is 70 ℃ clear paste, dried under reduced pressure, crushed, added artificial bezoar fine powder and auxiliary materials, mixed, granulated with 75% ethanol, dried, pressed into...

Examples

preparation example Construction

[0044] A preparation method of anti-liver cancer drug Sanjie Tablets, comprising the Sanjie Tablets containing Radix Aconiti, Qinglongyi, Baixianpi, and artificial bezoar. The preparation method comprises the following steps:

[0045] Step 1, removing the toxins in the components of Aconite Radix, Qinglongyi, and Fresh Cortex in the Sanjie Tablets to obtain non-toxic Radix Aconiti, Qinglongyi, and Fresh Cortex powder;

[0046] Step 2: Mix the non-toxic Radix Aconiti, non-toxic Qinglongyi, non-toxic white fresh bark powder and artificial bezoar obtained in Step 1, granulate with volatile medium, dry, compress into tablets, and coat with film to obtain the product.

[0047] Further, the toxin in the Qinglongyi composition in the described removal Sanjie tablet comprises the steps:

[0048] Step 1, directly preparing the fresh Qinglongyi as Qinglongyi homogenate or pulverizing the fresh Qinglongyi dry product into Qinglongyi coarse powder;

[0049] Step 2: Take probiotics and mi...

Embodiment 1

[0075] Non-toxic Qinglongyi powder is made by the following method: Homogenize fresh Qinglongyi directly; take bifidobacteria and 35 ºC distilled water according to the volume ratio of 1:40 and mix them evenly to make bifidobacteria liquid. Bifidobacteria liquid OD600=0.63, then according to the ratio of adding 2800mL Bifidobacterium liquid to 1 kg of Qinglongyi homogenate, take the Bifidobacterium liquid and add it to Qinglongyi homogenate, mix well, and ferment at 30°C After culturing for 4 days, the aeration ratio is 2 (v / v), the stirring rate is 150r / min, and then the fermented Qinglongyi fermentation mixture is dried at 45ºC and crushed into fine powder, which is the avirulent bifidobacterium fermented Qinglong Clothing powder.

Embodiment 2

[0077] The toxins in the components of Qinglongyi are removed by the following method: crush the dried medicinal materials of Qinglongyi into a coarse powder; take Saccharomyces cerevisiae and 30 ºC distilled water in a volume ratio of 1:20 and mix them evenly to make a Saccharomyces cerevisiae liquid. Liquid OD600=0.81, and according to the ratio of adding 3000mL Saccharomyces cerevisiae liquid to 1 kg Qinglongyi coarse powder, take Saccharomyces cerevisiae liquid and add Qinglongyi coarse powder, mix evenly, ferment and cultivate at 36°C for 3 days, the aeration ratio 5 (v / v), stirring rate 200r / min, then dry the fermented Qinglongyi fermentation mixture at 55ºC, and grind it into a fine powder, which is non-toxic Saccharomyces cerevisiae fermented Qinglongyi powder.

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