Conveyor and blood flow guiding stent system

Abstract

A transporter includes an inner core assembly and a restraint member. The restraint member is rotatably disposed on the inner core assembly. The restraint member sequentially includes a fixed ring, a connecting rib, and a clamping section from the proximal end to the distal end. Two ends of the connecting rib are respectively connected to the fixed ring and the clamping section. The fixed ring is rotatably disposed on the inner core assembly. The clamping section has a contracted configuration and an expanded configuration. In the contracted configuration, the clamping section is configured to clamp the proximal end of the blood flow guiding stent between the inner core assembly and the clamping section, and the friction coefficient of the surface of the clamping section close to the inner core assembly is greater than the friction coefficient of the surface of the clamping section on the side away from the inner core assembly. In the expanded configuration, the clamping section is separated from the blood flow guiding stent. The above transporter can prevent the blood flow guiding stent from twisting and slipping during transportation, has a relatively small pushing resistance, and is easy to load. The present application also provides a blood path guiding stent system.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a conveyor and a blood flow guiding stent system. Background Art

[0002] This section merely provides background information related to the present disclosure and is not necessarily prior art.

[0003] Intracranial aneurysms are mostly abnormal bulges on the walls of intracranial arteries, and are the leading cause of subarachnoid hemorrhage. Subarachnoid hemorrhage is one of the main types of hemorrhagic stroke in clinical practice. There are two main methods of treating aneurysms: surgical clipping and interventional treatment. Clinical trials have found that the mortality rate of interventional treatment for aneurysm patients is lower than that of surgical treatment.

[0004] Blood flow diverting stent is an emerging treatment method for intracranial aneurysms in recent years. Its principle is to reconstruct the correct path of blood vessels at the aneurysm site and restore the direction of blood flow. It can reshape the blood flow direction of intracranial blood vessels and gradually shrink the aneurysm until it disappears. Compared with coil embolization therapy, blood flow diverting stent is safer, more effective and has a wider adaptability.

[0005] The blood flow guiding stent needs to be used in conjunction with a conveyor. The friction component with an elastic silicone pad on the conveyor guide wire pushes the blood flow guiding stent to the aneurysm position through the microcatheter and releases it. The specific principle is: the elastic silicone pad fits the blood flow guiding stent to the inner wall of the microcatheter by squeezing the inner wall of the blood flow guiding stent. When the pushing component of the conveyor is pushed, the friction between the elastic silicone pad and the blood flow guiding stent is greater than the friction between the blood flow guiding stent and the microcatheter. The elastic silicone pad and the blood flow guiding stent are in a relatively static state, while the blood flow guiding stent and the conveyor are in a sliding state relative to the microcatheter, thereby realizing the delivery of the blood flow guiding stent in the microcatheter. However, this method has the following problems:

[0006] 1) During the pushing process, friction will be generated between the blood flow guide device and the inner wall of the microcatheter, resulting in a certain pushing resistance. When passing through curved blood vessels, the pushing resistance is particularly obvious, and even the pushing may not be smooth;

[0007] 2) During the pushing process, the blood flow guiding stent and the delivery guide wire may slide relative to each other, causing the blood flow guiding stent as a whole to move backward relative to the delivery device, resulting in wire deformation at the tail of the blood flow guiding stent. When the stent is released, the tail of the blood flow guiding stent may not be able to restore the predetermined shape, resulting in stent orifice stenosis after implantation, affecting the patient's postoperative effect;

[0008] 3) When passing through a curved blood vessel, the delivery guide wire will twist uncontrollably. The delivery guide wire and the pushing component of the delivery device will restrict the blood flow guiding stent, causing it to rotate along with the delivery guide wire, thus causing the blood flow guiding stent to twist. When the blood flow guiding stent is released, the blood flow guiding stent may not expand and open normally, affecting the use effect;

[0009] 4) Since the head and tail ends of the blood flow guiding stent are generally open braided wire ends, when the blood flow guiding stent is pre-installed into the loading catheter, the ends of the braided wires are easily stuck in the catheter opening and cannot smoothly enter the loading catheter. Summary of the invention

[0010] The purpose of the present invention is to solve at least one of the problems existing in the existing conveyor. This purpose is achieved through the following technical solutions:

[0011] An embodiment of the present application provides a conveyor, which comprises:

[0012] Core components; and

[0013] A restraint, which is rotatably disposed on the inner core component, and the restraint comprises a fixing ring, a connecting rib and a clamping section in sequence from the proximal end to the distal end, the two ends of the connecting rib are respectively connected to the fixing ring and the clamping section, the fixing ring is rotatably disposed on the inner core component, and the clamping section has a contraction configuration and an expansion configuration, in which the clamping section is used to clamp the proximal end of the blood flow guiding stent between the inner core component and the clamping section, and the friction coefficient of the surface of the clamping section close to the inner core component is greater than the friction coefficient of the surface of the clamping section away from the inner core component, and in the expansion configuration, the clamping section is separated from the blood flow guiding stent.

[0014] In one embodiment, the clamping section includes a clamping plate and a woven mesh connected to the clamping plate, the woven mesh and the clamping plate are connected end to end to form a tubular structure, and a coating layer is provided on the woven mesh.

[0015] In one embodiment, there are a plurality of the clamping sheets and a plurality of the woven meshes, and the plurality of the clamping sheets and the plurality of the woven meshes are alternately distributed.

[0016] In one embodiment, the clamping sheet and the woven mesh are an integral structure.

[0017] In one embodiment, a silicone gasket is provided on the surface of the clamping plate close to the inner core component, and a gasket is provided at a position of the inner core component corresponding to the clamping plate, and the gasket is sleeved on the inner core component.

[0018] In one embodiment, a first developing member and a second developing member are disposed on the inner core assembly, wherein the first developing member is located at a distal end of the gasket, and the second developing member is located at a proximal end of the gasket.

[0019] In one embodiment, a smooth layer is provided on the surface of the clamping sheet away from the inner core component.

[0020] In one embodiment, the fixing ring is a developing structure.

[0021] In one embodiment, the inner core assembly includes a delivery guide wire and a pushing rod connected to the delivery guide wire, and the restraining member can be rotatably disposed on the delivery guide wire.

[0022] In one embodiment, a hollow structure is provided on the connecting rib.

[0023] A blood flow guiding stent system comprises a blood flow guiding stent and any one of the above-mentioned conveyors, wherein the blood flow guiding stent is sleeved on the inner core component, and the proximal end of the blood flow guiding stent is restrained between the restraining member and the inner core component.

[0024] In one embodiment, the blood flow guiding stent is woven from metal wires, the metal wires include an inner layer and an outer layer disposed on the inner layer, the inner layer is made of a developing material, and the outer layer is made of an elastic material.

[0025] The above-mentioned conveyor and blood flow guiding stent system have at least the following beneficial effects:

[0026] 1) The restraint on the conveyor can wrap the proximal end of the blood flow guiding stent, which can facilitate the pre-installation of the blood flow guiding stent into the loading catheter, prevent the open metal wire at the proximal end of the blood flow guiding stent from being stuck in the catheter port, and reduce the difficulty of loading the blood flow guiding stent.

[0027] 2) The friction coefficient of the clamping section of the restraint away from the surface of the inner core component is small (the surface is nickel-titanium alloy and is provided with a smooth layer), which can reduce the friction between the restraint and the microcatheter, thereby reducing the resistance during pushing.

[0028] 3) The blood flow guiding stent is constrained between the silicone gasket of the restraining part and the gasket of the conveyor. The inner and outer layers of the blood flow guiding stent are squeezed and constrained, which can increase friction, prevent the blood flow guiding stent from slipping on the conveyor, and improve the connection reliability between the blood flow guiding stent and the conveyor.

[0029] 4) The restraint is rotatably arranged on the inner core assembly. When the inner core assembly is twisted during the delivery process, the restraint and the blood flow guiding stent may not rotate along with the delivery guide wire, so the blood flow guiding stent will not be twisted, thereby preventing the blood flow guiding stent from failing to expand and open normally during the release process, affecting the use effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] Various other advantages and benefits will become apparent to those of ordinary skill in the art by reading the detailed description of the preferred embodiments below. The accompanying drawings are only for the purpose of illustrating the preferred embodiments and are not to be considered as limiting the present invention. Moreover, the same reference symbols are used throughout the accompanying drawings to represent the same components. In the accompanying drawings:

[0031] Figure 1 is a schematic structural diagram of a blood flow guiding stent system in one embodiment of the present invention;

[0032] Figure 2 for Figure 1 A schematic diagram of the structure of a blood flow guiding stent of a blood flow guiding stent system shown;

[0033] Figure 3 for Figure 1 A schematic diagram of the structure of a conveyor of a blood flow guiding stent system is shown;

[0034] Figure 4 for Figure 3 A schematic diagram of the structure of the restraining member of the conveyor shown in the expanded state;

[0035] Figure 5 for Figure 3 A schematic diagram of the structure of the conveyor restraining member in a compressed state;

[0036] Figure 6 for Figure 3 The schematic diagram of the structure of the push rod of the conveyor in one embodiment is shown;

[0037] Figure 7 Figure 3 A schematic structural diagram of a push rod of a conveyor in another embodiment shown;

[0038] Figure 8-Figure 15 They are schematic diagrams of the structure of the blood flow guiding stent system of the present application during operation;

[0039] Fig.16 A schematic diagram of a blood flow guiding stent in the prior art being developed under DSA;

[0040] Fig.17 for Figure 2 Schematic diagram of blood flow diverting stent under DSA

[0041] Fig.18 This is a schematic structural diagram of a restraining member according to a second embodiment of the present application. DETAILED DESCRIPTION

[0042] The exemplary embodiments of the present disclosure will be described in more detail below with reference to the accompanying drawings. Although the exemplary embodiments of the present disclosure are shown in the accompanying drawings, it should be understood that the present disclosure can be implemented in various forms and should not be limited by the embodiments described herein. On the contrary, these embodiments are provided in order to enable a more thorough understanding of the present disclosure and to fully convey the scope of the present disclosure to those skilled in the art.

[0043] It should be understood that the terms used herein are for the purpose of describing specific example embodiments only and are not intended to be limiting. Unless the context clearly indicates otherwise, the singular forms "a", "an", and "said" as used herein may also be meant to include plural forms. The terms "comprise", "include", "contain", and "have" are inclusive and therefore specify the presence of stated features, steps, operations, elements, and / or parts, but do not exclude the presence or addition of one or more other features, steps, operations, elements, parts, and / or combinations thereof.

[0044] Although the terms first, second, third, etc. can be used in the text to describe multiple elements, components, regions, layers and / or sections, these elements, components, regions, layers and / or sections should not be limited by these terms. These terms can only be used to distinguish an element, component, region, layer or section from another region, layer or section. Unless the context clearly indicates, terms such as "first", "second" and other numerical terms do not imply order or sequence when used in the text. Therefore, the first element, component, region, layer or section discussed below can be referred to as the second element, component, region, layer or section without departing from the teaching of the example embodiments.

[0045] For ease of description, spatial relative terms may be used herein to describe the relationship of one element or feature relative to another element or feature as shown in the figure, such as "inside", "outside", "inner side", "outer side", "below", "below", "above", "above", etc. Such spatial relative terms are intended to include different orientations of the device in use or operation in addition to the orientation depicted in the figure. For example, if the device in the figure is turned over, then the elements described as "below other elements or features" or "below other elements or features" will subsequently be oriented as "above other elements or features" or "above other elements or features". Therefore, the example term "below..." can include both upper and lower orientations. The device can be oriented otherwise (rotated 90 degrees or in other directions) and the spatial relative descriptors used in the text are interpreted accordingly.

[0046] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art of the present invention. The terms used herein in the specification of the present invention are only for the purpose of describing specific embodiments and are not intended to limit the present invention. The term "and / or" used herein includes any and all combinations of one or more related listed items.

[0047] It should be noted that in this application, the end closer to the operator during use is called the "proximal end", and the end farther from the operator is called the "distal end", and the "proximal end" and "distal end" of any component of the blood flow guiding stent system are defined based on this principle.

[0048] See also Figure 1 The blood flow guiding stent system 10 of the first embodiment of the present application includes a blood flow guiding stent 100 and a conveyor 200. The conveyor 200 is used to convey the blood flow guiding stent 100 to the lesion site (such as an aneurysm).

[0049] See also Figure 2 , which is a schematic diagram of the structure of the blood flow guiding stent 100 of the present application. The blood flow guiding stent 100 is woven and shaped by 24-96 metal wires. For example, the blood flow guiding stent 100 is woven and shaped by 36, 48 or 64 metal wires. In one embodiment, the wire diameter of the metal wire is 0.01mm-0.05mm, and preferably, the wire diameter of the metal wire is 0.02mm-0.03mm. In one embodiment, the PPI of the blood flow guiding stent 100 is 230-300. In the present application, PPI is the weft density of weaving, that is, the mesh number of the blood flow guiding stent on the axial length of 1 inch. In one embodiment, the PPI of the blood flow guiding stent 200 is 250-280. In one embodiment, the diameter of the blood flow guiding stent 200 is 1.5mm-1.8mm.

[0050] Existing blood flow guiding stents are generally made of nickel-titanium alloy wires or cobalt-chromium alloy wires and 2-8 platinum developing wires. This type of stent structure cannot effectively observe the effect of all metal wires fitting the blood vessels under DSA (digital subtraction angiography). Fig.16 The effect diagram of the blood flow guiding stent under DSA in the prior art. In one embodiment, the metal wire includes an inner layer and an outer layer disposed on the inner layer, the inner layer is made of a developing material, such as platinum and its alloys, or tantalum and other metal materials with good developing properties, and the outer layer is made of an elastic material, such as cobalt-nickel alloy, nickel-titanium alloy, etc. Since the inner layer is made of a developable material, the blood flow guiding stent 200 can be effectively developed under DSA, and the fit between the blood flow guiding stent 200 and the blood vessel can be effectively observed. Fig.17 The effect diagram of the blood flow guiding stent 200 of the present application under DSA is shown. In one embodiment, the cross-sectional area of ​​the inner layer accounts for 20%-50% of the cross-sectional area of ​​the metal wire, and preferably, the cross-sectional area of ​​the inner layer accounts for 30%-45% of the cross-sectional area of ​​the metal wire.

[0051] In one embodiment, the metal wire surface of the blood flow guiding stent 200 is provided with an anti-thrombotic layer. Specifically, the material of the anti-thrombotic coating is phosphorylcholine, which is the main component of the phosphatidylcholine that constitutes the outer structure of the cell membrane. The surface of the phosphatidylcholine group with equal positive and negative charges is recognized to have good blood compatibility. The benefit of this coating is that it can reduce the occurrence of thrombus on the surface of the blood flow guiding stent and prevent the patient from having complications of thromboembolism after the blood flow guiding stent is implanted. In one embodiment, the anti-thrombotic coating can be a heparin-like material. Heparin is a commonly used coagulation substance in clinical practice and can effectively prevent thrombosis.

[0052] Please also read Figure 3 The conveyor 100 includes an inner core assembly 110 and a restraint 120, and the restraint 120 is rotatably disposed on the inner core assembly 110. The inner core assembly 110 includes a delivery guide wire 111 and a push rod 112 connected to the delivery guide wire, and the restraint 120 is rotatably disposed on the delivery guide wire 111. Since the restraint 120 can rotate relative to the delivery guide wire 111, when the delivery guide wire 111 is twisted during the delivery process, the restraint 120 and the blood flow guiding stent 200 may not rotate with the delivery guide wire 111, so the blood flow guiding stent 200 will not be twisted, thereby avoiding the blood flow guiding stent 200 from not being able to expand and open normally during the release process, affecting the use effect.

[0053] In one embodiment, the diameter of the delivery guide wire 111 gradually increases from the distal end to the proximal end, the diameter of the distal end of the delivery guide wire 111 is 0.03mm-0.1mm, and the diameter of the proximal end is 0.1mm-0.2mm. The delivery guide wire 111 is made of stainless steel or nickel-titanium alloy.

[0054] In one embodiment, the inner core component 110 further includes a developing spring coil 113 disposed at the distal end of the conveying guide wire 111, that is, the developing spring coil 112 is located at the farthest end of the inner core component 110 to ensure that the distal end of the inner core component 110 is visible under DSA, thereby helping to determine the position and movement direction of the conveyor 10 relative to the surrounding blood vessels. In one embodiment, the developing spring coil 113 is wound by a metal wire, and the material of the metal wire can be platinum, tungsten, gold, silver, tantalum, nickel-titanium alloy, cobalt-chromium alloy, platinum-tungsten alloy, platinum-iridium alloy, etc. The metal wire used has a certain developing property under DSA (digital subtraction angiography), and the wire diameter of the metal wire is between 0.01 and 0.1 mm. In one embodiment, the diameter of the developing spring coil 113 is between 0.2-0.5 mm.

[0055] In one embodiment, the distal end of the delivery guide wire 111 is further provided with a distal developing member 114, which is provided at the position where the delivery guide wire 111 is connected to the developing spring coil 112, and is used to develop and locate the distal end of the blood flow guiding stent 200. The distal developing member 114 is made of a metal material that can be developed, and its material can be platinum, tungsten, gold, silver, tantalum, nickel-titanium alloy, cobalt-chromium alloy, platinum-tungsten alloy, platinum-iridium alloy, etc. The distal developing member 114 is a hollow structure with a circular hole, and the distal developing member 114 passes through the delivery guide wire 111 and is fixed to the proximal end of the developing spring coil 113. In one embodiment, the distal end of the distal developing member 114 is cone-shaped, and the proximal end is cylindrical, and the proximal end of the distal developing member 114 can be used to abut against the distal end of the blood flow guiding stent 200, that is, after assembly, the distal end of the blood flow guiding stent 200 covers the proximal end of the distal developing member 114. In one embodiment, the diameter of the cylinder at the proximal end of the distal developing member 114 is 0.3 mm-0.6 mm.

[0056] In one embodiment, the restraining member 120 is rotatably disposed at the proximal end of the delivery guide wire 111. Figure 4 The restraining member 120 includes a fixing ring 121, a connecting rib 122 and a clamping section 123 from the proximal end to the distal end, and the two ends of the connecting rib 122 are connected to the fixing ring 121 and the clamping section 123 respectively. Figure 3The fixing ring 122 is rotatably disposed on the inner core assembly 110, and the clamping section 123 has a contracted configuration and an expanded configuration. In the contracted configuration, the clamping section 123 is used to clamp the proximal end of the blood flow guiding stent 200 between the inner core assembly 110 and the clamping section 123, and the friction coefficient of the surface of the clamping section 123 close to the inner core assembly 110 is greater than the friction coefficient of the surface of the clamping section 123 away from the inner core assembly 110. In the expanded configuration, the clamping section 123 is separated from the blood flow guiding stent 200. When the conveyor is pushed in the microcatheter, the friction between the blood flow guiding stent 200 and the surface of the clamping section 123 close to the inner core assembly 110 is greater than the friction between the surface of the clamping section 123 away from the inner core assembly 110 and the inner wall of the microcatheter, which can prevent the blood flow guiding stent 200 from slipping on the restraining member 120.

[0057] In one embodiment, the clamping section 123 includes a clamping sheet 1231 and a braided mesh 1232 connected to the clamping sheet 1231, the braided mesh 1232 and the clamping sheet 1231 are connected end to end to form a tubular structure, and the braided mesh 1232 is provided with a coating layer 1234. In one embodiment, the clamping sheet 1231 and the braided mesh 1232 are both multiple, and the multiple clamping sheets 1231 and the multiple braided meshes 1232 are alternately distributed. In the illustrated embodiment, the clamping sheet 1231 and the braided mesh 1232 are both three, and the three clamping sheets 1231 and the three braided meshes 1232 together form a mesh structure. In one embodiment, the coating layer 1234 covers the inner layer of the braided mesh 1232 (i.e., the surface close to the inner core component 110), and the coating layer 1234 can be a PTFE film.

[0058] Figure 4 1 is a schematic diagram of the structure of the restraining member 120 in an expanded state. In a natural state, the restraining member 120 is in an expanded state. The braided mesh 1232 is naturally unfolded and forms a tubular structure with an outer diameter of 1 mm to 4 mm with the clamping sheet 1231. Figure 5 Schematic diagram of the structure of the restraint 120 in a compressed state. In the compressed state, the braided mesh 1231 is compressed and forms a tubular structure with an outer diameter of 0.5mm-0.6mm with the clamping sheet 1231. It should be noted that the outer diameters of the braided mesh 1232 and the clamping sheet 1231 in the expanded state and the compressed state can be designed according to actual needs, so that the blood flow guiding stent 200 can be restrained between the inner core component 110 and the restraint 120 in the compressed state, and the blood flow guiding stent 200 can be released from the restraint 120 in the expanded state.

[0059] Because when the restraint 120 is in a compressed state, the clamping sheet 1231 and the woven mesh 1232 can form a closed tubular structure without gaps (the gaps in the woven mesh 1232 after compression can be covered by the coating layer 1234). When the blood flow guiding stent 200 is loaded, the clamping sheet 1231 and the woven mesh 1232 can completely wrap the blood flow guiding stent 200. Compared with the mesh restraint structure, the structure of the clamping sheet 1231 and the woven mesh 1232 of the present application can prevent the woven wire at the end of the blood flow guiding stent 200 from leaking out of the restraint 120, and can effectively prevent the blood flow guiding stent 200 from being stuck in the catheter. Moreover, when in the expanded state, the woven mesh 1232 and the clamping plate 1231 can also form a closed and seamless tubular structure (the mesh holes of the woven mesh 1232 are covered by the coating layer 1234), which can also prevent the woven wires at the end of the blood flow guiding stent 200 from being pierced into the mesh holes when released, thereby reducing the probability of the blood flow guiding stent 200 being unable to be separated from the restraint.

[0060] In addition, the braided mesh 1232 can have a certain restraining effect on the clamping piece 1231, allowing the clamping piece 1231 to form a tubular structure under compression, avoiding misalignment between the clamping pieces 1231 and causing the braided wire at the end of the blood flow guiding stent 200 to leak out of the restraint 120, thereby reducing the difficulty of assembly.

[0061] In one embodiment, the clamping piece 1231 and the braided mesh 1232 are an integrated structure. Specifically, the clamping piece 1231 and the braided mesh 1232 are carved from a superelastic nickel-titanium tube. In this embodiment, the clamping piece 1231, the braided mesh 1232 and the connecting ribs 122 are all carved from the same nickel-titanium tube.

[0062] In one embodiment, the fixing ring 121 is a developing structure, and the relative position of the constraint 120 and the microcatheter tube mouth can be observed through the fixing ring 121. Generally, a developing ring is provided at the distal tube mouth of the microcatheter. When the fixing ring 121 exceeds the position of the developing ring at the distal end of the microcatheter, the constraint 120 has completely left the microcatheter, the constraint 120 is in an expanded state, and the blood flow guiding stent 200 has completely withdrawn from the microcatheter. At this time, the conveyor 100 can be withdrawn to allow the conveyor 100 to enter the microcatheter.

[0063] In one embodiment, the fixing ring is a double-layer structure, including an inner layer and an outer layer, the inner layer is made of a developing material, and the outer layer is made of the same material as the connecting rib 122, and the inner layer and the outer layer can be connected together by welding or bonding. In one embodiment, the outer layer, the connecting rib 122, and the clamping section 123 are carved from the same nickel-titanium tube to make the structure of the restraint 120 more firm and stable. In one embodiment, the inner diameter of the outer layer is the same as the outer diameter of the inner layer, and the axial lengths of the inner layer and the outer layer are equal. In one embodiment, the inner diameter of the inner layer of the fixing ring 121 is 0.16mm-0.30mm. Of course, the inner diameter of the inner layer of the fixing ring 121 can also be designed according to actual needs, such as according to the outer diameter of the delivery guide wire 111, so that the fixing ring 121 can rotate on the delivery guide wire 111.

[0064] See also Figure 4 One end of the connecting rib 122 is connected to the clamping piece 1231, and the other end is connected to the fixing ring 121. In the illustrated embodiment, the connecting rib 122 is a strip structure, each clamping piece 1231 is connected to a connecting rib 122, and a plurality of connecting ribs 122 are evenly distributed along the circumference of the fixing ring 121.

[0065] In one embodiment, a silicone gasket 1233 is provided on the surface of the clamping sheet 1231 close to the inner core component 110, and a gasket 115 is provided at the position of the inner core component 110 corresponding to the clamping sheet 1231, and the gasket 115 is sleeved on the inner core component 110. In the illustrated embodiment, the silicone gasket 1233 is the same size as the clamping sheet 1231, and each clamping sheet 1231 is provided with a silicone gasket 1233. By adding the silicone gasket 1233, the friction coefficient of the silicone gasket 1233 is larger, so that the friction coefficient of the clamping sheet 1231 close to the surface of the inner core component 110 is larger. The gasket 115 is sleeved on the conveying guide wire 111. When the restraint 120 is in a compressed state, the silicone gasket 1233 can fit on the gasket 115. In the compressed state, the blood flow guiding stent 200 is restrained between the gasket 115 and the silicone gasket 1233. In this way, the inner and outer layers of the blood flow guiding stent 200 are respectively restrained by the gasket 115 and the silicone gasket 1233, which can make it have a larger static friction force and prevent the blood flow guiding stent 200 from slipping on the conveyor 100.

[0066] In one embodiment, the gasket 115 is a double-layer structure, the inner layer is a polymer material round tube, the material of the round tube can be polypropylene, polyimide, etc., and the outer layer is silicone. In one embodiment, the inner diameter of the inner layer is 0.16mm-0.25mm, the outer diameter is 0.3mm-0.4mm, the outer diameter of the outer layer is 0.55mm-0.60mm, the inner diameter of the outer layer is determined according to the outer diameter of the inner layer, and the length of the gasket 115 is 2mm-4mm. It should be noted that in other embodiments, the size of the gasket 115 can be designed according to actual needs to match the specific delivery guide wire 111.

[0067] In one embodiment, a smooth layer is provided on the surface of the clamping sheet 1231 away from the inner core component 110, for example, a super-slip PTFE hydrophilic coating is provided on the surface of the clamping sheet 1231 away from the inner core component 110. In other embodiments, the smooth layer can also be made of other materials, and the smooth layer mainly reduces the friction coefficient of the surface of the clamping sheet 1231 away from the inner core component 110, so as to reduce the friction between the clamping sheet 1231 and the microcatheter during the pushing process, thereby reducing the pushing resistance.

[0068] In one embodiment, the delivery guide wire 111 is further provided with a first developing member 116 and a second developing member 117. The first developing member 116 is located at the distal end of the gasket 115, and the second developing member 117 is located at the proximal end of the gasket 115. Specifically, the proximal end of the first developing member 116 abuts against the distal end of the gasket 115, and the distal end of the second developing member 117 abuts against the proximal end of the gasket. In one embodiment, the material of the first developing member 116 is the same as that of the distal developing member 113, and the structure of the first developing member 116 is similar to that of the distal developing member 113. The distal end of the first developing member 116 is also conical, and the proximal end is cylindrical. In one embodiment, the outer diameter of the cylinder of the first developing member 116 is the same as that of the gasket 115, that is, the outer surface of the first developing member 116 is flush with the gasket 115. In one embodiment, the outer diameter of the cylinder of the first developing member 115 is 0.3 mm-0.5 mm. The material of the second developing member 117 is the same as that of the first developing member 116. Figure 3, the second developing member 117 includes two coaxial and integrally arranged cylinders, wherein the diameter of the cylinder arranged near the gasket 115 is smaller than the diameter of the cylinder arranged far from the gasket 115. In one embodiment, the outer diameter of the cylinder with a smaller diameter is 0.3 mm-0.5 mm, and the outer diameter of the cylinder with a larger diameter is 0.5 mm-0.6 mm. The sum of the length of the second cylinder with a smaller diameter and the axial length of the gasket 115 is approximately equal to the axial length of the clamping piece 1231. After the blood flow guiding stent 200 and the conveyor 100 are loaded, the proximal end of the blood flow guiding stent 200 is clamped between the clamping piece 1231 and the gasket 115, and covers the cylindrical part of the first developing member 116 and the cylinder with a smaller diameter in the second developing member 117. The first developing member 116 and the second developing member 117 can be used to determine whether the blood flow guiding stent 200 is displaced relative to the conveyor 100.

[0069] Please also read Figure 6 , the distal end of the push rod 112 is connected to the proximal end of the delivery guide wire 111, and the outer diameter of the push rod 112 is larger than the outer diameter of the delivery guide wire 111. The fixing ring 122 is rotatably disposed on the delivery guide wire 111 and is limited between the second developing member and the distal end of the push rod 112. In one embodiment, the outer diameter of the push rod 112 is 0.4mm-0.6mm. The push rod 112 includes a distal portion 1121 and a proximal portion 1122 connected to the distal portion 1121, and the hardness of the distal portion 1121 is less than the hardness of the proximal portion 1122. The distal portion 1121 is a hypotube. Specifically, the distal portion 1121 of the push rod 112 can be formed by laser engraving a spiral hollow groove through a nickel-titanium alloy or stainless steel metal tube. Please refer to Figure 6 The distal end portion 1121 of the push rod 112 includes at least segment A, segment B, segment C, segment D and segment E from the distal end to the proximal end. The pitch of segment A is smaller than the pitch of segment B, the pitch of segment B is smaller than the pitch of segment C, the pitch of segment C is smaller than the pitch of segment D, and the pitch of segment D is smaller than the pitch of segment E, so that the distal end portion 1121 has a gradual hardness, which is convenient for passing through curved blood vessels. In one embodiment, the distal end portion 1121 of the push rod 112 is also provided with a polymer sleeve (such as a PTFE sleeve) to prevent the distal end portion 1121 from untwisting. The proximal end portion 1122 of the push rod 112 is a solid structure. In the illustrated embodiment, the proximal end portion 1122 of the push rod 112 includes a metal tube extending from the distal end portion 1121 of the push rod and a solid steel wire inserted in the metal tube, and the metal tube of the proximal end portion 1122 has no hollow structure. In other embodiments, the proximal portion 1122 of the push rod 112 may also be other structures. Figure 7The proximal portion 1122 of the push rod 112 may also be other structures. The proximal portion 1122 includes a solid steel wire, and the solid steel wire is connected to the distal portion 1121 by welding. The distal portion 1121 of the push rod 112 is relatively soft and can pass through curved blood vessels, while the proximal portion 1122 is relatively hard and has a relatively strong support strength, and can have a better pushing performance. In one embodiment, the length of the distal portion 1121 is 70mm-120mm, and the total length of the push rod 112 is 150mm-200mm.

[0070] See also Figures 8 to 15 One embodiment of the present application further provides an operation method of a blood flow diverting stent system 10 . The blood flow diverting stent system 10 further includes a loading catheter 20 .

[0071] Step S1: The delivery device 10 is inserted into the loading catheter 20 and the loading catheter 20 is located at the position of the pushing rod 112. Then the blood flow guiding stent 200 passes through the delivery guide wire 111 and the proximal end thereof is inserted into the restraining member 120 in the expanded state. Figure 8 It is a structural schematic diagram of the assembly process of the blood flow guiding stent system 10 and the loading catheter 20.

[0072] Step S2: withdraw the push rod 112. At this time, the restraint 120 enters the loading catheter 20 and is in a compressed state. At the same time, the blood flow guiding stent 200 is fixed between the clamping section 123 and the gasket 115. Continue to withdraw the push rod 112 until the blood flow guiding stent 200 is completely pulled into the loading catheter 20. Fig. 9 It is a schematic diagram of the structure of the blood flow guiding stent system 10 in the loading catheter 20.

[0073] Step S3: inserting the loading catheter 20 into the microcatheter 30 (at this time the microcatheter 30 has reached the lesion location), pushing the conveyor 100, and pushing the blood flow guiding stent 200 into the microcatheter 30. Fig.10 It is a structural schematic diagram of a loading catheter 20 loaded with a blood flow guiding stent system 10 being inserted into a microcatheter 30. Fig.11 Schematic diagram of the structure of the blood flow guiding stent system 10 located in the microcatheter 30 , where the restraining member 120 is in a compressed state in the microcatheter 30 .

[0074] Step S4: Push the push rod 112 of the conveyor 100 until the distal end of the blood flow guiding stent 200 reaches the distal end of the microcatheter 30 (which can be determined by observing the relative position of the distal developing member 114 and the developing ring 31 at the distal end of the microcatheter 30), withdraw the microcatheter 30, and release the distal end of the blood flow guiding stent 200 from the distal end of the microcatheter 30 and self-expand and unfold in the blood vessel. Fig.12It is a schematic diagram of the structure after the blood flow guiding stent 200 is partially released. At this time, the distal end of the blood flow guiding stent 200 has been released from the distal end of the microcatheter 30 and self-expanded, and the proximal end of the blood flow guiding stent 200 is still restrained in the microcatheter 30 by the restraint 120. If the position of the blood flow guiding stent 200 is not suitable at this time, the push rod 112 can be withdrawn to pull the blood flow guiding stent 200 back into the microcatheter 30.

[0075] Step S5: When the release position of the blood flow guiding stent 200 is appropriate, the microcatheter 30 is continued to be withdrawn, and the restraint 120 is gradually exposed from the microcatheter 30 until the fixing ring 121 of the restraint 120 is exposed from the microcatheter 30, and the conveyor 100 is withdrawn to allow the blood flow guiding stent 200 to be fully expanded and deployed. Fig.13 When the fixing ring 121 of the restraint 120 just reaches the distal end of the microcatheter 30 and the proximal end of the blood flow guiding stent 200 is still in the restraint 120, the release position of the blood flow guiding stent 200 can be adjusted by fixing the conveyor 100 and pushing the microcatheter 30 to retract the restraint 120 holding the proximal end of the blood flow guiding stent 200 into the microcatheter 30. Fig.14 It is a schematic diagram of the structure of the blood flow guiding stent 200 after being completely released in the blood vessel.

[0076] Step S6: withdraw the delivery device 100 into the micro-catheter 30, and withdraw the micro-catheter 30 and the delivery device 100 from the body. Fig.15 It is a schematic diagram of the structure in which the restraining member 120 is withdrawn into the micro-catheter 30 .

[0077] The above-mentioned blood flow guiding stent system 10 has at least the following beneficial effects:

[0078] 1) The restraint 120 on the conveyor 10 can wrap the proximal end of the blood flow guiding stent 200, so that the blood flow guiding stent 200 can be easily pre-installed into the loading catheter, preventing the open metal wire at the proximal end of the blood flow guiding stent from getting stuck in the catheter port, thereby reducing the difficulty of loading the blood flow guiding stent 200.

[0079] 2) The clamping section 123 of the restraint 120 has a smaller friction coefficient away from the surface of the inner core component 110 (the surface is nickel-titanium alloy and is provided with a smooth layer), which can reduce the friction between the restraint and the microcatheter, thereby reducing the resistance during pushing.

[0080] 3) The blood flow guiding stent 200 is constrained between the silicone gasket 1233 of the restraint 120 and the gasket 115 of the conveyor 100. The inner and outer layers of the blood flow guiding stent 200 are squeezed and constrained, which can increase the friction, prevent the blood flow guiding stent 200 from slipping on the conveyor 100, and improve the connection reliability between the blood flow guiding stent 200 and the conveyor 100.

[0081] 4) The restraint 120 is rotatably disposed on the inner core assembly 110. When the delivery guide wire 111 is twisted during the delivery process, the restraint 120 and the blood flow guiding stent 200 may not rotate along with the delivery guide wire 111. Therefore, the blood flow guiding stent 200 will not be twisted, thereby preventing the blood flow guiding stent 200 from failing to expand and open normally during the release process, thereby affecting the use effect.

[0082] See also Fig.18 The blood flow guiding stent system (not shown) of the second embodiment of the present application is substantially the same in structure as the blood flow guiding stent system 10 of the first embodiment, and the main difference is that the connecting ribs 122a of the restraining member 120a of the conveyor (not shown) are provided with hollow structures 1221. By providing the hollow structures 1221, the flexibility of the connecting ribs 122a can be increased, and the connecting ribs 122a can be made easier to bend without generating a large elastic force, so that the restraining member 120a can be better pulled into the loading catheter or microcatheter.

[0083] In one embodiment, there are multiple hollow structures, and the multiple hollow structures 1221 are arranged along the axial direction of the connecting rib 122a. The hollow structure can be rectangular or diamond-shaped, and the size of its longest side is not greater than the width of the connecting rib 122a.

[0084] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0085] The above-mentioned embodiments only express several implementation methods of the present invention, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the scope of the invention patent. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the present invention, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention shall be subject to the attached claims.

Claims

1. A conveyor, It is characterized in that include: Inner core components; and A restraint, the restraint being rotatably disposed on the inner core component, the restraint comprising a clamping section, the clamping section having a contracted configuration and an expanded configuration, in the contracted configuration, the clamping section is used to clamp the proximal end of the blood flow guiding stent between the inner core component and the clamping section, and the friction coefficient of the surface of the clamping section close to the inner core component is greater than the friction coefficient of the surface of the clamping section away from the inner core component, in the expanded configuration, the clamping section is separated from the blood flow guiding stent; The clamping section includes a clamping plate and a woven mesh connected to the clamping plate. The woven mesh and the clamping plate are connected end to end to form a tubular structure. In the contracted configuration, the clamping plate and the woven mesh form a closed and seamless tubular structure. The clamping plate and the woven mesh are an integral structure, and the clamping plate and the woven mesh are carved from the same nickel-titanium tube.

2. The conveyor according to claim 1, It is characterized in that There are multiple clamping sheets and multiple braided nets, and the multiple clamping sheets and the multiple braided nets are alternately distributed.

3. The conveyor according to claim 1, It is characterized in that A silicone gasket is arranged on the surface of the clamping piece close to the inner core component, and a gasket is arranged at a position of the inner core component corresponding to the clamping piece, and the gasket is sleeved on the inner core component.

4. The conveyor according to claim 1, It is characterized in that The woven mesh is provided with a coating layer.

5. The conveyor according to claim 1, It is characterized in that A smooth layer is provided on the surface of the clamping sheet away from the inner core component.

6. The conveyor according to claim 1, It is characterized in that The restraining member further comprises a fixing ring and a connecting rib. The fixing ring is rotatably arranged on the inner core component. Two ends of the connecting rib are respectively connected to the fixing ring and the clamping piece.

7. The conveyor according to claim 6, It is characterized in that The fixing ring is a developing structure.

8. The conveyor according to claim 1, It is characterized in that The inner core component comprises a delivery guide wire and a pushing rod connected to the delivery guide wire, and the restraining member can be rotatably arranged on the delivery guide wire.

9. A blood flow guiding stent system, comprising a blood flow guiding stent, It is characterized in that It comprises the conveyor according to any one of claims 1 to 8, wherein the blood flow guiding stent is sleeved on the inner core component, and the proximal end of the blood flow guiding stent is restrained between the restraining member and the inner core component.

10. The blood flow guiding stent system according to claim 9, It is characterized in that The blood flow guiding stent is woven from metal wires, the metal wires include an inner layer and an outer layer arranged on the inner layer, the inner layer is made of developing material, and the outer layer is made of elastic material.

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