blood analyzer
By setting up an isolation gas column between the sampling needle and the diluent solution, and setting the detection pipeline of the vascular subsidence detection module with respect to the sampling needle, the problem of blood sample dilution and loss in the blood analyzer is solved, and the measurement accuracy and accuracy are improved.
Patent Information
- Application Number
- CN202110878480.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Priority Date
- 2020-07-31
- Filing Date
- 2021-07-30
- Publication Date
- 2025-08-15
- Estimated Expiration
- 2041-07-30
AI Technical Summary
In existing blood analyzers, the structural design of the ESR detection module and sampling module is unreasonable, resulting in the blood sample being easily diluted by the diluent or being lost in the connecting pipeline, affecting the measurement accuracy.
Set an isolating air column between the sampling needle and the diluent solution, and set the detection pipeline of the vascular subsidence detection module with respect to the sampling needle to reduce the length of the connecting pipeline to prevent blood sample dilution and loss.
It improves the measurement accuracy of the blood analyzer, ensures that the blood sample is not diluted during the detection process, reduces sample loss, and improves the accuracy of the detection.
Smart Images

Figure CN114062209B_ABST
Abstract
Description
Technical Field
[0001] The present invention relates to the technical field of medical equipment, and more particularly to a blood analyzer. Background Art
[0002] In the bloodstream, red blood cells (RBCs) are dispersed and suspended due to the flow of blood and the mutual repulsion of negative charges on their surface. However, when blood is left alone, RBCs sink due to gravity. In pathological conditions, the types and levels of plasma proteins change, altering the charge balance in the blood and reducing the negative charge on the RBC surface. This in turn causes the RBCs to form a rouleaux-shaped structure and accelerate sedimentation. Therefore, measuring the RBC sedimentation rate (ESR)—the rate at which RBCs settle within one hour—can be used to assist in disease assessment.
[0003] In the application scenario of blood in clinical testing, routine blood test is also an indispensable test indicator. Therefore, there is a need for an all-in-one machine that can detect both ESR and routine blood test to meet the clinical needs of blood testing projects. The all-in-one machine has a sampling module that separates blood for the routine blood test module and the erythrocyte sedimentation rate test module (ESR test module). The structural design of the ESR test module and the sampling module in the current all-in-one machine is not reasonable, so that the blood sample allocated to the ESR module is easily diluted by the diluent or lost in the connecting pipeline, resulting in insufficient measurement accuracy. Summary of the Invention
[0004] In view of this, the present invention provides a blood analyzer to solve the problem of insufficient measurement accuracy of erythrocyte sedimentation rate detection. The technical solution is as follows:
[0005] A blood analyzer comprises: a sampling and distribution module, comprising a sampling device and a sample separation device for collecting blood samples, the sampling device comprising a sampling needle and a first power device, the first power device being used to drive the sampling needle to collect blood samples, and the sample separation device being used to distribute the collected blood samples to different detection modules; an erythrocyte sedimentation rate detection module, comprising a detection pipeline and an optical detection device, the detection pipeline providing a detection location for the blood sample, and the optical detection device being used to irradiate the blood sample in the detection pipeline with light and detect the degree of absorption or scattering of light by the blood sample in the detection pipeline to obtain the erythrocyte sedimentation rate of the blood sample Reduction rate; a routine blood test module, comprising a routine blood test pool and a routine blood test device, the routine blood test pool provides a testing place for blood samples, and the routine blood test device is used to perform routine blood tests on the blood samples in the routine blood test pool; a liquid circuit support module is used to provide liquid circuit support for the sampling distribution module, the erythrocyte sedimentation rate detection module and the routine blood test module; the sampling device also includes a sample suction pipeline connecting the sampling needle and the first power device; the liquid circuit support module is connected to the sample suction pipeline, at least part of the sample suction pipeline is filled with a diluent, and after the sampling needle collects the blood sample, an isolation gas column is provided between the blood sample and the diluent.
[0006] Optionally, the volume of the isolation gas column is greater than or equal to 5 μL and less than or equal to 20 μL.
[0007] Optionally, the volume of the isolation gas column is greater than or equal to 10 μL and less than or equal to 15 μL.
[0008] Optionally, the detection pipeline is part of the sample suction pipeline, and the optical detection device is arranged on both sides of the sample suction pipeline; the sample separator is connected to the sample suction pipeline, and after the sampling needle completes sampling, the sample separator draws at least part of the blood sample close to the isolation gas column into the detection pipeline.
[0009] Optionally, the volume distance between the detection pipeline and the sampling needle tip is greater than a preset volume distance and less than or equal to 200 μL, and the preset volume distance is the sum of a preset maximum sample aspiration volume and the volume of the isolation gas column.
[0010] Optionally, the erythrocyte sedimentation rate detection module also includes a heater, which is used to heat the blood sample in the detection pipeline. The distance from the heater to the tip of the sampling needle is greater than the preset volume distance and less than or equal to 200 μL. The preset volume distance is the sum of the preset maximum sample aspiration volume and the volume of the isolation gas column.
[0011] Optionally, the blood analyzer further includes a controller, which controls the sample splitting device to first distribute the first portion of the blood sample near the sampling needle tip to the routine blood test pool, and then distribute the second portion of the blood sample near the isolation gas column to the erythrocyte sedimentation measurement module.
[0012] Optionally, the detection pipeline is connected to the sample suction pipeline; the sample separation device is connected to the detection pipeline, and after the sampling needle completes sampling, the sample separation device draws at least part of the blood sample close to the isolation gas column into the detection pipeline.
[0013] Optionally, the volume distance between the detection pipeline and the sampling needle tip is greater than a preset volume distance and less than or equal to 200 μL, and the preset volume distance is the sum of a preset maximum sample aspiration volume and the volume of the isolation gas column.
[0014] Optionally, the routine blood test pool is connected to the sample suction pipeline, and the sample separator is connected to the routine blood test pool. After the sampling needle completes sampling, the sample separator draws at least part of the blood sample close to the isolation gas column into the routine blood test pool; the volume distance between the routine blood test pool and the needle tip of the sampling needle is greater than the preset volume distance and less than or equal to 200 μL, and the preset volume distance is the sum of the preset maximum sample suction volume and the volume of the isolation gas column.
[0015] A blood analyzer, characterized in that it includes: a sampling and distribution module, including a sampling device for collecting blood samples, the sampling device including a sampling needle and a first power device, the first power device is used to drive the sampling needle to collect blood samples, and the sampling device is used to distribute the collected blood samples to different detection modules; an erythrocyte sedimentation rate detection module, including a detection pipeline and an optical detection device, the detection pipeline provides a detection location for the blood sample, the optical detection device is used to irradiate the blood sample in the detection pipeline with light and detect the degree of absorption or scattering of light by the blood sample in the detection pipeline to obtain the erythrocyte sedimentation rate of the blood sample; a routine blood test module, including a routine blood test pool and a routine blood test device, the routine blood test pool provides a detection location for the blood sample, and the routine blood test device is used to perform routine blood test on the blood sample in the routine blood test pool; the detection pipeline is connected to the sampling needle, and the detection pipeline is stationary relative to the sampling needle in at least one movement direction.
[0016] Optionally, the detection pipeline is arranged on the sampling distribution module.
[0017] Optionally, the sampling distribution module includes a motion component and a driving device, the sampling needle is installed on the motion component, and the driving device is used to drive the motion component and the sampling needle to move along a predetermined direction; the detection pipeline is arranged on the motion component.
[0018] Optionally, the motion component includes a lateral motion component and a vertical motion component which respectively perform lateral motion and vertical motion under the drive of the driving device, and the detection pipeline is arranged on the lateral motion component or the vertical motion component.
[0019] Optionally, the erythrocyte sedimentation rate detection module is arranged on the sampling distribution module.
[0020] Compared with the prior art, the present invention has the following beneficial effects:
[0021] The blood analyzer provided by the present invention provides an isolation gas column between the sampling needle and the diluent to minimize dilution of the blood sample, or allows the detection pipeline of the erythrocyte sedimentation rate detection module to be statically arranged relative to the sampling needle so that the connecting pipeline between the two is shorter to reduce blood sample loss, thereby improving measurement accuracy. BRIEF DESCRIPTION OF THE DRAWINGS
[0022] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are merely embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on the provided drawings without paying any creative work.
[0023] Figure 1 A schematic diagram illustrating a blood analyzer according to an embodiment;
[0024] Figure 2 A schematic diagram showing a partial structure of a blood analyzer according to an embodiment;
[0025] Figure 3 A schematic diagram of a blood analyzer according to an embodiment is shown, wherein the instrument is in a sample aspiration process;
[0026] Figure 4 A schematic diagram of a blood analyzer according to an embodiment is shown, wherein the instrument is in a routine blood separation process;
[0027] Figure 5 A schematic diagram of a blood analyzer according to an embodiment is shown, wherein the instrument is in the erythrocyte sedimentation rate test process;
[0028] Figure 6 A schematic diagram showing a partial structure of a blood analyzer according to an embodiment;
[0029] Figure 7 A schematic diagram showing a partial structure of a blood analyzer according to one embodiment. DETAILED DESCRIPTION
[0030] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.
[0031] The present invention will be further described in detail below by means of specific embodiments in conjunction with the accompanying drawings. Similar elements in different embodiments are numbered with associated similar elements. In the following embodiments, many detailed descriptions are provided to enable the present application to be better understood. However, those skilled in the art will readily appreciate that some of the features may be omitted in different circumstances, or may be replaced by other elements, materials, or methods. In some cases, some operations related to the present application are not shown or described in the specification. This is to avoid the core portion of the present application being overwhelmed by excessive descriptions, and for those skilled in the art, it is not necessary to describe these related operations in detail. They will fully understand the related operations based on the description in the specification and the general technical knowledge in the art.
[0032] In addition, the features, operations, or characteristics described in the specification may be combined in any appropriate manner to form various embodiments. Furthermore, the steps or actions in the method description may be reordered or adjusted in a manner readily apparent to those skilled in the art. Therefore, the various sequences in the specification and drawings are provided solely for the purpose of clearly describing a particular embodiment and are not intended to be mandatory, unless otherwise specified.
[0033] The serial numbers assigned to components herein, such as "first," "second," etc., are used solely to distinguish the objects being described and do not convey any sequential or technical meaning. References to "connection" and "coupling" herein, unless otherwise specified, include both direct and indirect connections (couplings).
[0034] like Figures 1 to 3 As shown, one embodiment of the present application provides a blood analyzer 100, comprising a sampling distribution module 10, an erythrocyte sedimentation rate detection module 20, a blood routine detection module 30, a fluid circuit support module 40, and a controller 50. The blood analyzer 100 may also include a protein detection module for detecting specific proteins or other detection modules.
[0035] The sampling and distribution module 10 is used to collect blood samples from the sample container 200 and distribute the blood samples to multiple detection modules. Specifically, the sampling and distribution module 10 includes a sampling device and a sampling device for collecting blood samples. The sampling device includes a sampling needle 11 and a first power device 12. The first power device 12 is used to drive the sampling needle 11 to collect blood samples; the sampling device is used to distribute the collected blood samples to different detection modules. The sampling device can distribute the collected blood samples to different detection modules in a variety of ways according to the structural settings of the detection modules, such as injecting the blood samples into different detection modules through a power source, or by drawing the blood samples from the sampling needle 11 into the detection pool or detection pipeline 21 of the detection module. Specifically, the first power device 12 is used to provide negative pressure to extract the blood sample from the sample container 200 into the sampling needle 11. The first power device 12 can be a pump, a syringe or other pressure source that can provide power, such as a positive and negative air pressure source.
[0036] It should be noted that the sampling device and the sample separation device in the sampling and distribution module 10 may include the same structure or different structures. For example, the sampling device includes a sampling needle 11 and a first power device 12. When collecting a blood sample, the first power device 12 provides negative pressure to extract the blood sample in the sample container 200 into the sampling needle 11; the sample separation device also includes a sampling needle 11 and a first power device 12. When distributing a blood sample, the first power device 12 provides negative pressure to draw the blood sample into the erythrocyte sedimentation rate detection module 20; the sample separation device may also include a power transposition that provides positive pressure or negative pressure to distribute the blood sample to the routine blood detection module 30.
[0037] The erythrocyte sedimentation rate detection module 20 includes a detection pipeline 21 and an optical detection device 22. The detection pipeline 21 is used to provide a detection location for the blood sample. The optical detection device 22 is arranged corresponding to the detection pipeline 21, and is used to irradiate the blood sample in the detection pipeline 21 with light and detect the degree of light absorption or scattering of the blood sample in the detection pipeline 21 to obtain the erythrocyte sedimentation rate of the blood sample. The optical detection device 22 includes a light source 221 and a photoelectric converter 222, and the light source 221 and the photoelectric converter 222 are used to measure the light absorption or light scattering of the blood sample in the detection pipeline 21. The erythrocyte sedimentation rate detection module 20 also includes a heater 23 and a temperature sensor 24, and the heater 23 and the temperature sensor 24 are used to control the temperature of the detection pipeline 21. The erythrocyte sedimentation rate detection module 20 may also include a pipeline fixing block for fixing the detection pipeline 21. In addition, the detection pipeline 21 and the optical detection device 22 can also be provided separately, that is, the detection pipeline 21 may not be fixed to the optical detection device 22, and the detection pipeline 21 moves with the sampling needle in at least one direction of movement. In other words, the detection pipeline 21 and the sampling needle 11 are stationary in at least one direction of movement. In one embodiment, when the sampling needle 11 moves to the sample container 200 to collect a blood sample, the detection pipeline 21 is connected to the sampling needle 11 and moves with the sampling needle 11; thereafter, the sampling needle dispenses the blood sample, and the first power device 12 provides negative pressure to draw the blood sample into the detection pipeline 21 located at the optical detection device (because the sampling needle 11 is connected to the pipeline, in fact, when the sampling needle moves, the pipeline also moves in the optical detection device 22. Therefore, after the sampling needle collects the sample, the section of the pipeline that transports the blood sample to the optical detection device 22 is the detection pipeline) for detection. In another embodiment, a certain section of the pipeline connected to the sampling needle 11 can be set as a detection pipeline. For example, a section of the pipeline close to the sampling needle can be set as a detection pipeline. After the sampling needle 11 completes blood sample collection, the first power device 12 provides negative pressure to draw the blood sample into the detection pipeline, and then the sampling needle 11 moves to bring the detection pipeline to the optical detection device 22 for detection.
[0038] The blood routine test module 30 includes a blood routine test pool 31 and a blood routine test device (not shown). The blood routine test pool 31 is used to provide a testing location for blood samples, and the blood routine test device performs blood routine tests on the blood samples in the blood routine test pool 31.
[0039] The liquid circuit support module 40 is used to provide liquid circuit support for the sampling and distribution module 10, the erythrocyte sedimentation rate detection module 20, and the routine blood test module 30; the liquid circuit support may include functional support such as fluid drive, reagent injection, liquid circuit cleaning, and waste liquid discharge. For example, the liquid circuit support module 40 can provide cleaning fluid to the sampling and distribution module 10, the erythrocyte sedimentation rate detection module 20, and the routine blood test module 30, respectively, to clean the sampling needle 11, the detection pipeline 21, and the routine blood test pool 31, respectively, to avoid contamination of the blood sample to be tested and causing inaccurate test results. In addition, the liquid circuit support module 40 can be connected to the sampling needle 11 through a pipeline, and the liquid circuit support module 40 keeps the pipeline filled with diluent, making the sampling, sample separation, and other processes faster and more reliable.
[0040] The controller 50 is communicatively connected to the sampling distribution module 10 , the erythrocyte sedimentation rate detection module 20 , the blood routine detection module 30 , and the fluid circuit support module 40 to process information and control the operation of each module.
[0041] The sampling device also includes a sample aspiration line 13 connecting the sampling needle 11 and the first power device 12; a fluid support module 40 is connected to the sample aspiration line 13, at least a portion of which is filled with a diluent. After the sampling needle 11 collects a blood sample, an isolation gas column 60 is provided between the blood sample and the diluent. Specifically, after the sampling needle 11 collects a blood sample, the blood sample is filled in the sampling needle 11, or in the sampling needle 11 and the sample aspiration line 13. A section of the isolation gas column 60 is provided between the blood sample and the diluent to isolate the blood sample from the diluent, thereby preventing the blood sample from being diluted. As an optional embodiment, before aspirating the sample, the liquid circuit support module 40 allows a portion of the sample aspiration line 13 to be filled with a diluent, while the portion of the sample aspiration line 13 and the sampling needle 11 near the sampling needle 11 are filled with gas. After aspirating the sample, an isolation gas column 60 is formed between the blood sample and the diluent. As another optional embodiment, before aspirating the sample, the liquid circuit support module 40 allows the sample aspiration line 13 to be filled with a diluent, while the sampling needle 11 is filled with gas. After aspirating the sample, an isolation gas column 60 is formed between the blood sample and the diluent. As another optional embodiment, before aspirating the sample, the liquid circuit support module 40 allows both the sample aspiration line 13 and the sampling needle 11 to be filled with a diluent. The sampling needle 11 first aspirates a preset volume or a certain amount of gas before aspirating the blood sample. After aspirating the sample, an isolation gas column 60 is formed between the blood sample and the diluent. The gas can be air or other gases that are insoluble in the diluent and the blood sample.
[0042] Preferably, the volume of the isolation gas column 60 is greater than or equal to 5 μL and less than or equal to 20 μL. Within this range, the isolation gas column 60 can effectively isolate the blood sample and diluent while maintaining the appropriate length of the sample aspiration line 13, ensuring rapid sample aspiration and sample separation. Furthermore, the volume of the isolation gas column 60 is greater than or equal to 10 μL and less than or equal to 15 μL. Within this range, the isolation gas column 60 is more effective in isolating the diluent and blood sample.
[0043] In this embodiment, Figure 2 As shown, the detection line 21 is part of the sample suction line 13, and the optical detection device 22 is disposed on both sides of the sample suction line 13. A sample separator is connected to the sample suction line 13. After the sampling needle 11 completes sampling, the sample separator draws at least a portion of the blood sample near the isolation gas column 60 into the detection line 21. In other words, the ESR detection module 20 is disposed on the sample suction line 13 near the sampling needle 11, using a portion of the sample suction line 13 as the detection line 21, eliminating the need for a separate detection line 21 and simplifying the structure. Based on this structural design, since the blood sample distributed to the ESR detection module 20 needs to flow through a section of the sample suction line 13 before reaching the detection line 21, and the sample suction line 13 is filled with diluent, it is even more necessary to provide an isolation gas column 60 between the blood sample and the diluent to reduce the degree of dilution of the blood sample flowing through the sample suction line 13. Specifically, during the process of the sampling needle 11 sucking the sample, the sample dividing device distributing the blood sample to the blood routine detection pool 31, and then sucking it into the detection pipeline 21, the diluent and the isolation gas column 60 move accordingly. Figures 3 to 5 It can be observed that the position of the isolation gas column 60 changes in the sample aspiration pipeline 13. The volume of the detection pipeline 21 is greater than or equal to 10 μL and less than or equal to 50 μL. Preferably, the volume of the detection pipeline 21 is 40 μL, so that the sample aspiration pipeline 13 has a suitable length.
[0044] The volume distance between the detection line 21 and the tip of the sampling needle 11 is greater than the preset volume distance and is less than or equal to 200 μL. Furthermore, the volume distance between the erythrocyte sedimentation rate detection module 20 and the tip of the sampling needle 11 is greater than the preset volume distance and is less than or equal to 200 μL. The preset volume distance is the sum of the preset maximum sample aspiration volume and the volume of the isolation gas column 60. The maximum sample aspiration volume is the maximum volume of blood sample that the sampling needle 11 of the blood analyzer 100 can absorb at one time, and the volume of the blood sample actually collected each time is less than or equal to the maximum sample aspiration volume. Such a design can not only ensure that the distance between the detection line 21 and the sampling needle 11 is close enough to reduce the dilution of the blood sample by the diluent remaining in the line and the blood remaining on the tube wall, but also ensure that the detection module and the isolation gas column 60 do not overlap, thereby avoiding the isolation gas column 60 being affected by the heating process of the erythrocyte sedimentation rate detection module 20 during the sample aspiration and sample separation process. It should be noted that the volume distance between the detection pipeline 21 and the needle tip of the sampling needle 11 is the volume distance between the end of the detection pipeline 21 close to the sampling needle 11 and the needle tip of the sampling needle 11; the volume distance between the erythrocyte sedimentation rate detection module 20 and the needle tip of the sampling needle 11 is the volume distance between the end of the erythrocyte sedimentation rate detection module 20 close to the sampling needle 11 and the needle tip of the sampling needle 11.
[0045] Specifically, the ESR testing module 20 also includes a heater 23, which is used to heat the blood sample in the testing tube 21. The distance between the heater 23 and the tip of the sampling needle 11 is greater than the preset volume distance and less than or equal to 200 μL. This design ensures that the heater 23 is close enough to the sampling needle 11 to reduce sample dilution by residual diluent in the tube and blood residue on the tube wall. It also prevents the heat from the heater 23 from causing thermal expansion of the isolation gas column 60, which could affect the accuracy of sample aspiration or subsequent sample separation.
[0046] Regarding the order of blood sample distribution, for samples that only undergo a routine blood test or an erythrocyte sedimentation rate test, the controller 50 controls the sample splitting device to distribute at least part of the blood sample to the corresponding test pool or test pipeline 21. For samples that require both a routine blood test and an erythrocyte sedimentation rate test, the controller 50 controls the sample splitting device to first distribute the first part of the blood sample near the needle tip of the sampling needle 11 to the routine blood test pool 31, and then distribute the second part of the blood sample near the isolation gas column 60 to the erythrocyte sedimentation rate measurement module, so that only the part of the blood sample undergoing the erythrocyte sedimentation rate test flows through the sample aspiration pipeline 13, and the part of the blood sample undergoing the routine blood test does not flow through the sample aspiration pipeline 13, thereby improving measurement efficiency. The controller 50 also controls the routine blood test module 30 to start measurement after the first part of the blood sample is distributed, and controls the erythrocyte sedimentation rate detection module 20 to start measurement after the second part of the blood sample is distributed, thereby improving measurement efficiency.
[0047] like Figure 6As shown, in another embodiment of the present invention, the detection line 21 is connected to the sample suction line 13. That is to say, the detection line 21 is no longer a part of the sample suction line 13, but is connected to the sample suction line 13, and the blood sample flows through the sample suction line 13 to the detection line 21. After the sampling needle 11 completes the sampling, the second power device 25 in the sample separation device draws at least part of the blood sample close to the isolation gas column 60 into the detection line 21. At this time, preferably, the volume distance between the erythrocyte sedimentation rate detection module 20 and the needle tip of the sampling needle 11 is greater than the preset volume distance and less than or equal to 200μL, and the preset volume distance is the sum of the preset maximum sample suction volume and the volume of the isolation gas column 60.
[0048] like Figure 7 As shown, in another embodiment of the present invention, the ESR detection module 20 is connected to the sampling needle 11. Specifically, the detection line 21 is connected to the sampling needle 11. That is, one outlet of the sampling needle 11 is connected to the sample aspiration line 13, and the other outlet is connected to the ESR detection module 20. In this case, the volume distance between the ESR detection module 20 and the tip of the sampling needle 11 is greater than the volume distance H between the outlet connected to the ESR detection module 20 and the tip of the sampling needle 11 and is less than or equal to 200 μL. Because the detection line 21 is closer to the sampling needle 11, the detection line 21 can be filled with no diluent or filled with diluent but without an isolation gas column. Of course, the detection line 21 can also be filled with diluent and provided with an isolation gas column 70. In this case, the volume distance between the ESR detection module 20 and the tip of the sampling needle 11 is greater than a preset volume distance and less than or equal to 200 μL. In this case, the preset volume distance is the sum of the volume distance H between the outlet connected to the ESR detection module 20 and the tip of the sampling needle 11 and the volume of the isolation gas column 70. Specifically, before the sampling needle 11 absorbs the blood sample, the second power device 25 in the sample separation device first absorbs a certain amount of gas so that an isolation gas column 70 is formed between the blood sample and the diluent after the sampling needle 11 absorbs the blood sample.
[0049] In another embodiment of the present invention, a routine blood test pool is connected to a sample aspiration line, and a sample splitting device is connected to the routine blood test pool. After the sampling needle completes sampling, the sample splitting device draws at least a portion of the blood sample proximal to the isolation gas column into the routine blood test pool. Preferably, the volume distance between the routine blood test pool and the sampling needle tip is greater than a preset volume distance and less than or equal to 200 μL; further, the volume distance between the routine blood test module and the sampling needle tip is greater than a preset volume distance and less than or equal to 200 μL, where the preset volume distance is the sum of a preset maximum sample aspiration volume and the volume of the isolation gas column.
[0050] like Figure 3As shown, in another embodiment of the present invention, the detection line 21 is connected to the sampling needle 11, and the detection line 21 is stationary relative to the sampling needle 11 in at least one direction of movement. The detection line 21 being connected to the sampling needle 11 here includes both direct connection of the detection line 21 to the sampling needle 11 and indirect connection of the detection line 21 to the sampling needle 11 via other structures such as the sample aspiration line 13. In short, the detection line 21 is stationary relative to the sampling needle 11 in at least one direction of movement, where the direction of movement here refers to the direction of movement of the sampling needle 11. In this case, when the sampling needle 11 moves, the distance between the sampling needle 11 and the detection line 21 in at least one direction remains unchanged. This allows for a shorter connecting line between the sampling needle 11 and the detection line 21, without having to consider the need to lengthen the connecting line accordingly when the sampling needle 11 moves relative to the detection line 21 during sample aspiration, sample splitting, etc., thereby reducing blood loss in the connecting line and the difficulty of cleaning. When the connecting line is filled with diluent, the dilution degree of the blood sample when it flows from the sampling needle 11 to the detection line 21 can also be reduced because the connecting line is shorter.
[0051] As an optional embodiment, the detection pipeline 21 is provided on the sampling distribution module 10. Figure 3-Figure 5 As shown, the ESR detection module 20 is disposed on the sampling and distribution module 10. The sampling and distribution module 10 includes a motion assembly and a drive device. The sampling needle 11 is mounted on the motion assembly. The drive device is used to drive the motion assembly and the sampling needle 11 to move in a predetermined direction. Specifically, the ESR detection module 20 is disposed on the motion assembly. In this embodiment, the drive device can be a motor. The motion assembly includes a transverse motion assembly 141 and a vertical motion assembly 142, which are driven by the drive device to perform transverse and longitudinal motions, respectively. The sampling and distribution module 10 also includes a transverse guide rail 143 and a vertical guide rail 144. The transverse motion assembly 141 is mounted on the transverse guide rail 143. The drive device drives the transverse motion assembly 141 to move along the transverse guide rail 143. The vertical guide rail 144 is mounted on the transverse motion assembly 141. The vertical motion assembly 142 is mounted on the vertical guide rail 144. The drive device drives the vertical motion assembly 142 to move along the vertical guide rail 144. The sampling needle 11 is mounted on the vertical motion assembly 142. The detection pipeline 21 can be set in either the lateral motion component 141 or the vertical motion component 142 . Figure 3-Figure 5 In the embodiment, the detection pipeline 21 is arranged in the lateral motion component 141. When the detection pipeline 21 is arranged in the lateral motion component 141, the lateral distance of the detection pipeline 21 relative to the sampling needle 11 remains unchanged; when the detection pipeline 21 is arranged in the vertical motion component 142, the distance of the detection pipeline 21 relative to the sampling needle 11 remains unchanged.
[0052] It is understood that regarding the structural arrangement of the motion assembly and the guide rail, the transverse guide rail 143 can also be mounted to the vertical motion assembly 142, in which case the sampling needle 11 is mounted to the transverse motion assembly 141. The detection line 21 can be mounted in either the transverse motion assembly 141 or the vertical motion assembly 142. When the detection line 21 is mounted in the transverse motion assembly 141, the distance between the detection line 21 and the sampling needle 11 remains unchanged. When the detection line 21 is mounted in the vertical motion assembly 142, the vertical distance between the detection line 21 and the sampling needle 11 remains unchanged.
[0053] It can be understood that the structure and movement form of the moving component carrying the sampling needle 11 are not limited to the forms included in the above-mentioned embodiments. For example, the driving device can drive the moving component to rotate. Similarly, since the detection pipeline 21 is arranged on the moving component, the detection pipeline 21 is stationary relative to the sampling needle 11.
[0054] Furthermore, the erythrocyte sedimentation rate detection module 20 is stationary relative to the sampling needle 11 in at least one direction of movement. Specifically, the erythrocyte sedimentation rate detection module 20 is disposed on the sampling distribution module 10, or on the motion component, or on the above-mentioned lateral motion component 141 or vertical motion component 142. The erythrocyte sedimentation rate detection module 20 includes at least a detection pipeline 21 and an optical detection device 22. The weight of the erythrocyte sedimentation rate detection module 20 is greater than or equal to 20g and less than or equal to 50g; the volume of the detection pipeline 21 is greater than or equal to 10μL and less than or equal to 50μL. Preferably, the volume of the detection pipeline 21 is 40μL.
[0055] Those skilled in the art will appreciate that all or part of the functions of the various methods in the above embodiments can be implemented by hardware or by computer program. When all or part of the functions in the above embodiments are implemented by computer program, the program can be stored in a computer-readable storage medium, and the storage medium can include: read-only memory, random access memory, disk, optical disk, hard disk, etc., and the program is executed by a computer to implement the above functions. For example, the program is stored in the memory of the device, and when the program in the memory is executed by the processor, all or part of the above functions can be implemented. In addition, when all or part of the functions in the above embodiments are implemented by computer program, the program can also be stored in a storage medium such as a server, another computer, disk, optical disk, flash disk or mobile hard disk, and saved in the memory of the local device by downloading or copying, or the system of the local device is updated. When the program in the memory is executed by the processor, all or part of the functions in the above embodiments can be implemented.
[0056] The above specific examples are used to illustrate the present invention, which are only used to help understand the present invention and are not intended to limit the present invention. For those skilled in the art, according to the concept of the present invention, the above specific embodiments can be modified.
Claims
1. A blood analyzer, characterized in that: include: A sampling and distribution module, comprising a sampling device for collecting blood samples and a sample distribution device for distributing the collected blood samples, wherein the sampling device comprises a sampling needle and a first power device, wherein the first power device is used to drive the sampling needle to collect blood samples, and the sample distribution device is used to distribute the collected blood samples to different detection modules; An erythrocyte sedimentation rate (ESR) detection module includes a detection pipeline and an optical detection device. The detection pipeline provides a detection location for a blood sample. The optical detection device is used to irradiate the blood sample in the detection pipeline with light and detect the degree of light absorption or scattering by the blood sample in the detection pipeline to obtain the erythrocyte sedimentation rate (ESR) of the blood sample. A routine blood test module includes a routine blood test pool and a routine blood test device. The routine blood test pool provides a testing location for blood samples, and the routine blood test device is used to perform routine blood tests on the blood samples in the routine blood test pool. The detection pipeline is connected to the sampling needle, and the detection pipeline is stationary relative to the sampling needle in at least one movement direction; the movement direction is the movement direction of the sampling needle.
2. The blood analyzer according to claim 1, characterized in that The detection pipeline is arranged on the sampling distribution module.
3. The blood analyzer according to claim 2, characterized in that The sampling distribution module includes a motion component and a driving device. The sampling needle is installed on the motion component. The driving device is used to drive the motion component and the sampling needle to move along a predetermined direction. The detection pipeline is arranged on the motion component.
4. The blood analyzer according to claim 3, characterized in that The motion component includes a lateral motion component and a vertical motion component which respectively perform lateral motion and vertical motion under the drive of the driving device, and the detection pipeline is arranged on the lateral motion component or the vertical motion component.
5. The blood analyzer according to claim 2, characterized in that The erythrocyte sedimentation rate detection module is arranged on the sampling distribution module.
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