A fully automatic plasma separation mechanism

Abstract

The present invention relates to a fully automatic plasma separation mechanism, comprising a centrifugal disc, a transfer tray and a centrifugal driving device arranged on one side of the transfer tray; the centrifugal driving device comprises a centrifugal driving motor and a centrifugal chuck arranged on the output shaft of the centrifugal driving motor, a through hole for the centrifugal chuck to pass through is arranged on the transfer tray, the centrifugal disc cooperates with the centrifugal chuck, and a lifting device for moving the centrifugal disc up and down is also arranged on the centrifugal driving device; the present invention utilizes the transfer tray to transfer the centrifugal disc to the centrifugal driving device, utilizes the centrifugal chuck on the centrifugal driving device to cooperate with the centrifugal disc, centrifuges the blood in the centrifugal disc, realizes the centrifugal function, and the whole process is completed automatically without human intervention.

Description

Technical Field

[0001] The invention belongs to the technical field of detection equipment, and in particular relates to a fully automatic plasma separation mechanism. Background Art

[0002] Currently, plasma separation is performed using a special centrifuge, which requires an operator to place the blood to be separated into the centrifuge. After centrifugation, the operator takes out the separated plasma and places it into the testing instrument. This requires a lot of manual operation as a whole, which is not conducive to instrument automation.

[0003] For example, the patent application with publication number CN109212240A discloses a high-throughput fully automatic immunoassay instrument, including a lower working unit, an upper working unit, a three-dimensional robotic arm and a pipette arranged on the three-dimensional robotic arm; the lower working unit includes a sample area, a tip storage area and a waste box arranged on the lower plate; the upper working unit includes a magazine storage area, a sample adding area, a ferrying area, an incubation area and a detection area arranged on the upper plate.

[0004] For another example, the patent application with publication number CN113049801A discloses an immunoassay analyzer, characterized in that the immunoassay analyzer includes: a frame; a reaction disk assembly, which is arranged on the frame, and the reaction disk assembly is used to load a reaction cup and circulate the reaction cup; a sample needle assembly, which is arranged on the frame and is used to reciprocate in a first direction for sampling and sample distribution, and the sample needle assembly is arranged above the reaction disk assembly to distribute samples to the reaction cup; a reagent storage disk, which is arranged on the frame and located on the side of the reaction disk assembly, and is used to refrigerate and store reagents; a reagent needle assembly, which is rotatably arranged on the frame and located between the reaction disk assembly and the reagent storage disk, and is used to take the reagent and add it to the reaction cup; an HCT calculation assembly, which is arranged below the movement trajectory of the sample needle assembly.

[0005] Through analysis, it can be seen that the current immunoassay analyzers can directly detect plasma when in use, and the immunoassay analyzers do not have a matching plasma separation structure, and the plasma separation operation needs to be performed on a centrifuge. Summary of the invention

[0006] The technical problem to be solved by the present invention is to provide a fully automatic plasma separation mechanism to realize automated separation operation.

[0007] The technical solution adopted by the present invention is: a fully automatic plasma separation mechanism, which includes a centrifugal disc, a transfer tray and a centrifugal drive device arranged on one side of the transfer tray;

[0008] The centrifugal drive device includes a centrifugal drive motor and a centrifugal chuck arranged on the output shaft of the centrifugal drive motor. A through hole for the centrifugal chuck to pass through is provided on the transfer tray. The centrifugal plate cooperates with the centrifugal chuck. A lifting device for moving the centrifugal drive device up and down is also provided on the centrifugal drive device.

[0009] Furthermore, a first gear is sleeved on the output shaft of the centrifugal drive motor, and a second gear is provided on one side of the centrifugal drive motor. The second gear is arranged on the output shaft of the stepper motor. The stepper motor is connected to the displacement drive device, and the displacement drive device drives the second gear to move so that it engages or disengages with the first gear.

[0010] Furthermore, the displacement drive device includes a first synchronous belt and a first displacement drive motor for driving the first synchronous belt to move. The stepper motor is fixedly mounted on the first slider and the first slider is slidably arranged on the first guide rod. The first slider is fixedly connected to the first synchronous belt.

[0011] Furthermore, the lifting device is a first screw motor.

[0012] Furthermore, a top plate is provided above the centrifugal drive device, and when the transfer tray moves to the position of the centrifugal drive device, the transfer tray is located below the top plate.

[0013] Furthermore, a spring glass bead structure is provided on the centrifugal chuck, and a special-shaped hole corresponding to the centrifugal chuck is provided on the centrifugal disk.

[0014] Furthermore, the transfer tray is arranged on the second guide rod through the second slider, the second guide rod is fixedly connected to the second synchronous belt, and the second displacement drive motor drives the second synchronous belt to operate.

[0015] Furthermore, a accommodating barrel for placing the centrifugal disc is provided on the other side of the transfer tray, a slot hole is opened at the bottom of the accommodating barrel and on the side corresponding to the transfer tray, and a push plate corresponding to the position of the slot hole is provided on the other side of the accommodating barrel; the push plate is slidably set on the third guide rod through a third slider, and the third slider is fixedly connected to the third synchronous belt driven by a third displacement drive motor; the height of the slot hole is higher than the thickness of one centrifugal disc and less than the thickness of two centrifugal discs.

[0016] Furthermore, an electromagnet is provided above the transfer tray, and a slideway is provided below the transfer tray and at a position corresponding to the electromagnet.

[0017] Furthermore, blood adding holes are correspondingly arranged on the top plate and the centrifugal disk.

[0018] The positive effects of the present invention are:

[0019] The present invention uses a transfer tray to transfer the centrifugal disk to a centrifugal drive device, and uses a centrifugal chuck on the centrifugal drive device to cooperate with the centrifugal disk to centrifuge the blood in the centrifugal disk to achieve the centrifugal function. The whole process is completed automatically without human intervention.

[0020] It is also equipped with a accommodating barrel in which several centrifugal discs can be stacked. The centrifugal disc at the bottom can be pushed onto the transfer tray using a push plate, thus realizing the automatic centrifugal disc loading operation. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 It is a schematic diagram of the structure of the present invention;

[0022] Figure 2 This is a schematic diagram of the structure of the container of the present invention;

[0023] Figure 3 This is a schematic diagram of the transfer tray structure of the present invention;

[0024] Figure 4 It is a schematic diagram of the position of the electromagnet of the present invention;

[0025] Figure 5 It is a schematic structural diagram of the centrifugal drive device of the present invention. DETAILED DESCRIPTION

[0026] Example 1

[0027] As attached Figure 1-5 As shown, the plasma separation mechanism of this embodiment includes a transfer tray 12 for transporting the centrifugal disk 6 and a centrifugal drive device arranged on one side of the transfer tray 12.

[0028] The centrifugal drive device includes a centrifugal drive motor 18 and a centrifugal chuck 20 mounted on its output shaft. The centrifugal drive motor 18 can move up and down under the drive of the lifting device. A through hole for the centrifugal chuck 20 to pass through is opened on the transfer tray 6, and a hole that can match the centrifugal chuck 20 is provided at the center of the centrifugal plate 6. In this embodiment, the lifting device is a first screw motor 17 arranged vertically.

[0029] At the same time, a first gear 19 is sleeved on the output shaft of the centrifugal drive motor 18 and located below the centrifugal chuck 20, a stepper motor 23 is provided on one side of the centrifugal drive motor 18, and a second gear 22 is provided on the output shaft of the stepper motor 23. At the same time, a first guide rod 27 is provided, on which a first slider 25 is slidably provided, the first slider 25 is connected to a first synchronous belt 26, the first displacement drive motor 24 drives the first synchronous belt 26 to move, and the first slider 25 is driven to move on the first guide rod 27 through the movement of the first synchronous belt 26, and the stepper motor 23 is fixedly installed on the first slider 25, thereby realizing the movement of the second gear 22, and realizing the meshing or disengagement of the second gear 22 with the first gear 19.

[0030] Preferably, a spring glass bead structure is provided on the centrifugal chuck 20, a special-shaped hole corresponding to the centrifugal chuck 20 is provided on the centrifugal disk 6, and a top plate 21 is provided above the centrifugal chuck 20. When the transfer tray 12 moves to the centrifugal drive device position, the transfer tray 12 is located below the top plate 21.

[0031] Blood adding holes 28 are correspondingly provided on the top plate 21 and the centrifugal disk 6 .

[0032] When the present embodiment is in use, the first screw motor 17 can lift up the centrifugal drive motor 18, the first gear 19, and the centrifugal chuck 20 when rotating, so that the centrifugal chuck 20 is inserted into the central positioning hole of the centrifugal disk 6, and the centrifugal chuck 20 continues to lift up the centrifugal disk 6 until the upper surface of the centrifugal disk 6 presses against the top plate 21, and then the centrifugal chuck 20 continues to lift up, and the centrifugal chuck 20 will be inserted into the central hole of the centrifugal disk 6. The centrifugal chuck 20 has a spring glass bead structure, and the centrifugal chuck 20 cooperates with the special-shaped hole in the center of the centrifugal disk, so that the centrifugal chuck and the centrifugal disk will be relatively fixed, and then the screw motor 17 rotates in the opposite direction, and the centrifugal disk 6 will fall. When the centrifugal disk 6 is not in contact with the top plate 21 and the transfer tray 12, the first displacement drive motor 24 drives the first synchronous belt 26 to rotate, and the first slider 25 fixedly connected to the first synchronous belt 26 will move along the first guide rod 27, that is, along Figure 5 The first slider 25 moves in the direction of the arrow shown in the figure, and the stepper motor 23 fixed to the first slider 25 and the second gear 22 fixed on its shaft move in the direction of the arrow until the second gear 22 is fully meshed with the first gear 19. The first displacement drive motor 24 stops rotating, and then the stepper motor 23 rotates, and the second gear 22 rotates accordingly, so that the first gear 19 meshing therewith rotates, and the first gear 19 is coaxial with the centrifugal chuck 20, so the centrifugal chuck 20 rotates together, and the centrifugal chuck 20 drives the centrifugal disk 6 to rotate. When the blood addition hole on the centrifugal disk 6 is aligned with the center of the blood addition hole 28 on the top plate 21, the stepper motor 23 stops rotating, the centrifugal disk 6 stops rotating, and the blood addition operation is performed.

[0033] After the blood addition action is completed, the first displacement drive motor 24 rotates in the opposite direction, causing the first synchronous belt 26 to rotate in the direction opposite to the arrow, and the second gear 22 moves away from the first gear 19. After the second gear 22 is completely separated from the first gear 19, the centrifugal drive motor 18 starts to rotate, and the centrifugal chuck 20 drives the centrifugal disk 6 to perform centrifugal action.

[0034] After centrifugation is completed, the first displacement drive motor 24 rotates to make the second gear 22 fully mesh with the first gear 19, and then the stepper motor 23 rotates to align the blood adding hole of the centrifugal disk 6 with the center of the blood adding hole 28 on the top plate 21 to perform the serum extraction operation. After the operation is completed, the first displacement drive motor 24 rotates in the opposite direction to make the second gear 22 completely disengaged from the first gear 19, and then the screw motor 17 rotates to make the centrifugal chuck 20 fall, and the centrifugal disk 6 falls. During the falling process, the centrifugal disk 6 will be supported by the transfer tray 12, and the centrifugal chuck 20 continues to fall and disengage from the centrifugal disk 6. When the centrifugal chuck 20 is completely disengaged from the positioning hole of the centrifugal disk 6 and the centrifugal chuck 20 is lower than the lower surface of the transfer tray 12, the transfer tray 12 can carry the centrifugal disk 6 for the disc withdrawal action.

[0035] Example 2

[0036] This embodiment is further limited on the basis of Embodiment 1. In this embodiment, the transfer tray 12 is set on the second guide rod 11 through the second slider 9. The second guide rod 11 is fixedly connected to the second synchronous belt 13. The second displacement drive motor 8 drives the second synchronous belt 13 to operate.

[0037] Example 3

[0038] This embodiment is further limited on the basis of the embodiment 2, and a receiving barrel 7 is provided on the other side of the transfer tray 12, and a plurality of centrifugal discs 6 are stacked in the receiving barrel 7. A rectangular groove is provided on the edge of the receiving barrel 7, which is in a "convex" shape, for facilitating the storage and access of the circular centrifugal discs. A slot hole is provided at the bottom of the receiving barrel 7 and on one side corresponding to the transfer tray 12, and the height of the slot hole is higher than the thickness of one centrifugal disc and less than the thickness of two centrifugal discs. A push plate 4 corresponding to the position of the slot hole is provided on the other side of the receiving barrel 7, and the push plate 4 can be used to push the centrifugal disc 6 at the bottom of the receiving barrel 7 out of the slot hole and push it onto the transfer tray 12.

[0039] The push plate 4 is slidably disposed on the third guide rod 5 via the third slider 3 , and the third slider 3 is fixedly connected to the third synchronous belt 2 driven by the third displacement driving motor 1 .

[0040] Meanwhile, an electromagnet 14 is provided between the storage barrel 7 and the centrifugal drive device and above the transfer tray 12 , a slide 15 is provided below the transfer tray 12 and at a position corresponding to the electromagnet 14 , and a base plate 16 with an opening is provided at the bottom end of the slide 15 .

[0041] The transfer tray 12 carries the centrifugal disk 6 after centrifugation. Figure 3 When the transfer tray 12 moves to below the electromagnet 14 in the direction of the arrow shown, the protruding end of the electromagnet 14 is inserted into the center hole of the centrifugal disk 6, and the insertion depth is less than the thickness of the centrifugal disk 6. When the transfer tray 12 continues to move in the direction shown in the figure, the centrifugal disk 6 is blocked by the protruding end of the electromagnet, and the centrifugal disk 6 can no longer continue to move forward with the transfer tray 12. When the centrifugal disk 6 escapes from the transfer tray 12, it falls into the slide 15 below. At the same time, the electromagnet 14 is turned off, and the centrifugal disk 6 continues to fall along the slide 15 to the opening of the base plate 16, completing the disk withdrawal action.

[0042] The workflow of the present invention is:

[0043] The third displacement drive motor 1 drives the push plate 4 to push the bottom centrifugal disc 6 in the centrifugal disc accommodating barrel 7 into the transfer tray 12 through the belt drive, and then the second displacement drive motor 8 drives the transfer tray 12 to transport the centrifugal disc 6 to the centrifugal chuck 20 through the belt drive, and then the centrifugal disc 6 is lifted from the transfer tray 12 through the coordinated movement of the centrifugal drive motor 18, the stepper motor 23, the second gear 22, the first gear 19, and the screw motor 17, and then the centrifugal disc 6 is centrifuged. After the centrifugation is completed, the transfer tray 12 carries the centrifugal disc 6 back. During the return process, when the centrifugal disc 6 reaches the position of the electromagnet 14, the protruding end of the electromagnet 14 is inserted into the centrifugal disc hole, blocking the centrifugal disc 6 but not blocking the transfer tray 12, so that the centrifugal disc 6 is disengaged from the transfer tray 12, and then the centrifugal disc 6 falls into the slideway 15 and slides into the hole 16, completing the automatic disc withdrawal operation.

[0044] The whole process of the present invention does not require human intervention, and only requires placing a plurality of centrifugal discs into the containing barrel 7, which greatly improves the automation of the instrument.

[0045] At present, the technical solution of the present invention has been put into pilot production, that is, a small-scale test of the product before large-scale mass production; after the pilot production was completed, a user usage survey was carried out in a small range, and the survey results showed that user satisfaction was high; now preparations have begun for the formal production of the product for industrialization (including intellectual property risk warning survey).

[0046] The above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit the same. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that the technical solutions described in the aforementioned embodiments may still be modified, or some of the technical features thereof may be replaced by equivalents. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A fully automatic plasma separation mechanism, characterized in that It comprises a centrifugal disc (6), a transfer tray (12) and a centrifugal drive device arranged on one side of the transfer tray (12); the centrifugal drive device comprises a centrifugal drive motor (18) and a centrifugal chuck (20) arranged on the output shaft of the centrifugal drive motor (18); a through hole for the centrifugal chuck (20) to pass through is provided on the transfer tray (12); the centrifugal disc (6) and the centrifugal chuck (20) cooperate with each other; and a lifting device for moving the centrifugal drive device up and down is also provided on the centrifugal drive device; A first gear (19) is sleeved on the output shaft of the centrifugal drive motor (18), a second gear (22) is provided on one side of the centrifugal drive motor (18), the second gear (22) is arranged on the output shaft of a stepping motor (23), the stepping motor (23) is connected to a displacement drive device, and the displacement drive device drives the second gear (22) to move so as to mesh with or disengage from the first gear (19); The displacement drive device comprises a first synchronous belt (26), a first displacement drive motor (24) for driving the first synchronous belt (26) to move, the stepping motor (23) is fixedly mounted on a first slider (25) and the first slider (25) is slidably arranged on a first guide rod (27), and the first slider (25) is fixedly connected to the first synchronous belt (26); The lifting device is a first screw motor (17); A top plate (21) is provided above the centrifugal drive device, and when the transfer tray (12) moves to the position of the centrifugal drive device, the transfer tray (12) is located below the top plate (21); A spring glass bead structure is provided on the centrifugal chuck (20), and a special-shaped hole corresponding to the centrifugal chuck (20) is provided on the centrifugal disk (6); The transfer tray (12) is arranged on the second guide rod (11) through the second slider (9), the second guide rod (11) is fixedly connected to the second synchronous belt (13), and the second displacement drive motor (8) drives the second synchronous belt (13) to operate; A receiving barrel (7) for accommodating a centrifugal disc is provided on the other side of the transfer tray (12); a slot hole is provided at the bottom of the receiving barrel (7) and on a side corresponding to the transfer tray (12); a push plate (4) corresponding to the position of the slot hole is provided on the other side of the receiving barrel (7); the push plate (4) is slidably arranged on a third guide rod (5) via a third slider (3); the third slider (3) is fixedly connected to a third synchronous belt (2) driven by a third displacement drive motor (1); the height of the slot hole is higher than the thickness of one centrifugal disc and lower than the thickness of two centrifugal discs; An electromagnet (14) is provided above the transfer tray (12), and a slideway (15) is provided below the transfer tray (12) and at a position corresponding to the electromagnet (14); Blood injection holes (28) are correspondingly provided on the top plate (21) and the centrifugal disk (6); When the transfer tray (12) moves with the centrifugal disk (6) after centrifugation to the bottom of the electromagnet (14), the extended end of the electromagnet (14) is inserted into the central hole of the centrifugal disk (6), and the insertion depth is less than the thickness of the centrifugal disk (6). When the transfer tray (12) continues to move, the centrifugal disk (6) is blocked by the extended end of the electromagnet (14), and the centrifugal disk (6) can no longer follow the transfer tray (12) to continue to move forward. When the centrifugal disk (6) escapes from the transfer tray (12), it falls into the slideway (15) below. At the same time, the electromagnet (14) is turned off, and the centrifugal disk (6) continues to fall along the slideway (15) to the opening of the base plate (16), completing the disk withdrawal action.

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