Neurostimulation electrode, neurostimulation device and neurostimulation system

Abstract

The present application provides a neural stimulation electrode, a neural stimulation device and a neural stimulation system, the neural stimulation electrode comprising: an electrode shell, the electrode shell comprising a hollow tube, and a stimulation head end, the stimulation head end being arranged inside the electrode shell, and the stimulation head end being used to conduct electrical stimulation energy to the tissue surface to electrically stimulate the tissue, and to collect electrical signals from the tissue, wherein the stimulation head end is capable of moving along the axial direction of the electrode shell within the electrode shell, and / or the stimulation head end is capable of rotating along the circumferential direction of the electrode shell within the electrode shell. According to the neural stimulation electrode of the present application, it is possible to electrically stimulate different parts of biological tissue using fewer stimulation contacts, and to achieve precise stimulation by collecting and analyzing electrical signals from different parts.

Description

Technical Field

[0001] The present application relates to the field of implantable medical devices, and in particular to a neural stimulation electrode, a neural stimulation device and a neural stimulation system. Background Art

[0002] The neurostimulation electrodes of the interventional neurostimulation devices of the prior art usually have multiple fixed stimulation contacts. During the operation, the medical staff implants the electrodes into specific areas of tissues such as the brain based on the existing knowledge and experience of specific diseases, so as to electrically stimulate the tissues, thereby achieving the purpose of treating certain diseases. Usually, in order to obtain a better combination of stimulation directions and points, the stimulation contacts will be preset as many as possible, for example, 8 contacts, 12 contacts, 24 contacts, etc., and corresponding connection lines will be set for each stimulation contact to transmit electrical stimulation energy. However, due to the small space in the neurostimulation electrode, it is difficult to set too many stimulation contacts and corresponding lines, and therefore limits the doctor's identification of the site of the disease and the flexibility of theoretical research and treatment of more stimulation contact sites. Summary of the invention

[0003] The purpose of the present application is to provide a neural stimulation device that can electrically stimulate different parts of biological tissue using fewer stimulation contacts, and achieve precise stimulation by collecting and analyzing electrical signals from different parts.

[0004] The present application also aims to provide a neural stimulation device and a neural stimulation system.

[0005] The purpose of this application is achieved by the following technical solutions:

[0006] In a first aspect, the present application provides a neural stimulation electrode, the neural stimulation electrode comprising:

[0007] an electrode housing, the electrode housing being a hollow tube, and

[0008] A stimulation head end is arranged inside the electrode housing and is used to conduct electrical stimulation energy to the tissue surface to electrically stimulate the tissue and collect electrical signals from the tissue.

[0009] Wherein, the stimulation head end can move in the electrode shell along the axial direction of the electrode shell, and / or the stimulation head end can rotate in the electrode shell along the circumferential direction of the electrode shell.

[0010] According to the nerve stimulation electrode of the present application, electrical stimulation of different parts of biological tissue can be achieved with fewer stimulation heads.

[0011] In some optional embodiments, the nerve stimulation electrode further includes an axis component, which is disposed inside the electrode housing and extends along the axial direction of the electrode housing.

[0012] Wherein, the stimulation head end is connected to the shaft component and can rotate around the axial direction of the electrode shell, so that the stimulation head end can rotate along the circumferential direction of the electrode shell.

[0013] According to the nerve stimulation electrode of the present application, the stimulation head end can rotate relative to the axial direction of the electrode shell, thereby rotating along the circumferential direction of the electrode shell, thereby achieving electrical stimulation of different parts of biological tissue.

[0014] In some optional embodiments, the stimulation head includes:

[0015] a stimulation contact for conducting electrical stimulation energy to a tissue surface to electrically stimulate the tissue, and

[0016] A signal collection contact is used to collect the electrical signal.

[0017] According to the neural stimulation electrode of the present application, it is possible to electrically stimulate different parts of biological tissue with fewer stimulation heads, and to achieve precise stimulation by collecting and analyzing electrical signals from different parts.

[0018] In some optional embodiments, the shape of the stimulation contact is at least one of an ellipse, a circle, a rounded rectangle, a rectangle, a triangle and a ring.

[0019] According to the nerve stimulation electrode of the present application, a suitable stimulation contact shape can be selected according to the characteristics of different tissues of a living body in actual surgery.

[0020] In some optional embodiments, the number of the stimulation heads is greater than one.

[0021] The nerve stimulation electrode according to the present application can better realize electrical stimulation of different parts of biological tissues.

[0022] In some optional embodiments, the electrode shell includes a honeycomb-shaped insulating part and a plurality of conductive parts separated by the insulating part, any two conductive parts are insulated from each other, and at least two stimulation heads are in contact with different conductive parts respectively.

[0023] According to the neural stimulation electrode of the present application, a honeycomb-shaped insulating part is provided to provide mutual insulation conditions for multiple conductive parts, and the wire function (conducting electrical stimulation, transmitting collected electrical signals) of the traditional neural stimulation electrode is realized by at least two stimulation heads respectively contacting different conductive parts. Compared with the traditional neural stimulation electrode which needs to use multiple wires to realize the interactive function between multiple electrodes and the pulse generator, only the movable stimulation head end is required to cooperate with the fixed electrode housing to play the interactive role, avoiding the sharp increase in process cost and maintenance cost due to too many wires. Each stimulation head end is connected to the pulse generator respectively, and when used, the stimulation head end can reach any position (the conduction between the stimulation head ends is realized through the corresponding conductive parts), so as to realize the doctor's needs of stimulating and collecting various parts of the patient's body tissue.

[0024] In some optional embodiments, the electrode shell includes a honeycomb-shaped insulating part and a plurality of semiconductor parts separated by the insulating part, any two semiconductor parts are insulated, each semiconductor part has a control end, a first connection end and a second connection end, the first connection end of each semiconductor part is connected to the signal transmission end to conduct the electrical stimulation energy or collect the electrical signal, and the second connection end of each semiconductor part extends to the tissue;

[0025] At least two stimulation heads are respectively in contact with control terminals of different semiconductor parts, and are used to turn on and off the first connection terminal and the second connection terminal of the contacted semiconductor parts.

[0026] According to the neural stimulation electrode of the present application, a honeycomb-shaped insulating part is provided to provide mutual insulation conditions for multiple semiconductor parts, and at least two stimulation heads are contacted with different semiconductor parts respectively to realize the wire function of the traditional neural stimulation electrode (conducting electrical stimulation, transmitting collected electrical signals). Compared with the traditional neural stimulation electrode that needs to use multiple wires to realize the interactive function between multiple electrodes and the pulse generator, only the movable stimulation head is required to cooperate with the fixed electrode shell to play an interactive role, avoiding the sharp increase in process cost and maintenance cost due to too many wires. Each stimulation head is connected to the pulse generator respectively, and when used, the stimulation head can reach any position (conduction between the stimulation heads is realized through the corresponding semiconductor parts), so as to realize the doctor's needs of stimulating and collecting various parts of the patient's body tissue.

[0027] In some optional embodiments, the types of diseases treated by the neural stimulation electrodes include one or more of epilepsy, tremor, Parkinson's disease, depression, obsessive-compulsive disorder, Alzheimer's disease, autism and drug addiction.

[0028] According to the neural stimulation electrode of the present application, the neural stimulation electrode can be applied to the above-mentioned various diseases to relieve the patient's pain.

[0029] In a second aspect, the present application provides a neural stimulation device, which comprises at least one neural stimulation electrode as described in any one of the foregoing.

[0030] According to the neural stimulation device of the present application, it is possible to electrically stimulate different parts of biological tissue using fewer stimulation contacts, and to achieve precise stimulation by collecting and analyzing electrical signals from different parts.

[0031] In some optional embodiments, the nerve stimulation device further comprises a driving unit, wherein the driving unit is configured to drive the stimulation head end to move along the axial direction of the electrode shell and to rotate along the circumferential direction of the electrode shell.

[0032] According to the nerve stimulation device of the present application, the movement and rotation of the nerve stimulation electrode can be controlled more accurately.

[0033] In some optional embodiments, the neural stimulation device further includes a control unit, which is configured to analyze the electrical signal and move the stimulation head end according to the analysis result of the electrical signal to achieve precise stimulation.

[0034] According to the neural stimulation device of the present application, it is possible to effectively analyze electrical signals at different parts to achieve precise stimulation.

[0035] In a third aspect, the present application provides a neural stimulation system, which comprises any one of the above-mentioned neural stimulation devices.

[0036] According to the neural stimulation system of the present application, it is possible to electrically stimulate different parts of biological tissue using fewer stimulation contacts, and to achieve precise stimulation by collecting and analyzing electrical signals from different parts. BRIEF DESCRIPTION OF THE DRAWINGS

[0037] The present application is further described below in conjunction with the accompanying drawings and embodiments.

[0038] Figure 1 is a schematic diagram of the structure of a neural stimulation electrode provided in an embodiment of the present application;

[0039] Figure 2 is a stereoscopic diagram of a stimulation head end and a shaft component provided in an embodiment of the present application;

[0040] Figure 3 It is a structural schematic diagram of a stimulation head end provided in an embodiment of the present application;

[0041] Figure 4 is a stereoscopic diagram of another stimulation head end and shaft component provided in an embodiment of the present application;

[0042] Figure 5 is a stereoscopic diagram of another stimulation head end and shaft component provided in an embodiment of the present application;

[0043] Figure 6 is a stereoscopic diagram of another stimulation head end and shaft component provided in an embodiment of the present application;

[0044] Figure 7 is a stereoscopic diagram of another stimulation head end and shaft component provided in an embodiment of the present application;

[0045] Figure 8 It is a schematic diagram of the structure of an electrode shell provided in an embodiment of the present application;

[0046] Fig. 9 is a schematic diagram of the structure of another electrode shell provided in an embodiment of the present application;

[0047] Fig.10 is a schematic structural diagram of a nerve stimulation device provided in an embodiment of the present application;

[0048] Fig.11 It is a structural schematic diagram of a segmented electrode provided by the prior art.

[0049] In the figure: 1. neural stimulation device; 10. neural stimulation electrode; 101. electrode housing; 1011. insulating part; 1012. conductive part; 1013. semiconductor part; 102. stimulation head end; 1021. stimulation contact; 1022. signal collection contact; 103. shaft component; 11. driving unit; 12. energy supply unit; 13. control unit. DETAILED DESCRIPTION

[0050] Below, the present application is further described in conjunction with the accompanying drawings and specific implementation methods. It should be noted that, under the premise of no conflict, the various embodiments or technical features described below can be arbitrarily combined to form a new embodiment.

[0051] See also Figure 1 and Figure 2 , Figure 1 FIG. 1 shows a schematic structural diagram of a neural stimulation electrode 10 provided in an embodiment of the present application. Figure 2 The present invention provides a three-dimensional diagram of a stimulation head end 102 and a shaft component 103 provided in an embodiment of the present invention. The present invention provides a neural stimulation electrode 10, and the neural stimulation electrode 10 includes:

[0052] The electrode shell 101 is a hollow tube, and

[0053] A stimulation head end 102, which is disposed inside the electrode housing 101 and is used to conduct electrical stimulation energy to the tissue surface to electrically stimulate the tissue and collect electrical signals from the tissue.

[0054] The stimulation head end 102 can move in the electrode shell 101 along the axial direction of the electrode shell 101 , and / or the stimulation head end 102 can rotate in the electrode shell 101 along the circumferential direction of the electrode shell 101 .

[0055] like Figure 1 In one embodiment of the present application, the nerve stimulation electrode 10 includes an electrode housing 101 and a stimulation head end 102. The electrode housing 101 is a hollow tube, and the stimulation head end 102 is accommodated inside the electrode housing 101. There is no specific limitation on the material of the electrode housing 101, and materials commonly used in the art can be used. In a specific application, the electrode housing 101 can be a flexible, elongated hollow tube.

[0056] In one embodiment of the present application, the stimulation head end 102 is connected to the energy supply unit 12 (described in detail below) via a wire, and is used to apply the electrical stimulation energy from the energy supply unit 12 to a specific part of the tissue of the organism, so as to achieve electrical stimulation of the specific part of the tissue (sometimes also referred to as "neural stimulation" in this article). At the same time, the stimulation head end 102 can also collect electrical signals from tissues in the organism. When the stimulated tissue is brain tissue, such electrical signal is, for example, an electroencephalogram signal. The embodiments of the present application do not limit the electrical signal generated, which can be a single-cell electrical signal generated by a single cell (electrical changes at the neuron level), or it can be a local field potential (central local electrical changes such as the nucleus level).

[0057] The present application does not limit the type of organism, which may be a human, or an animal such as a monkey, rabbit, cat, dog, etc.

[0058] In one embodiment of the present application, the stimulation head end 102 is able to move inside the electrode housing 101. There is no particular limitation on the specific manner in which the stimulation head end 102 moves inside the electrode housing 101. For example, the stimulation head end 102 can move (translate) along the axial direction of the electrode housing 101, or the stimulation head end 102 can rotate (rotate) along the circumference of the electrode housing 101. Preferably, the stimulation head end 102 can rotate 360 ​​degrees along the circumference of the electrode housing 101, and the control accuracy of the rotation angle can be at the millimeter level, micrometer level or nanometer level, realizing a smooth and continuous adjustment function similar to a stepless speed switch. Through the translation and rotation movement of the stimulation head end 102, different parts of the biological tissue can be stimulated by a small number of stimulation head ends 102, and the electrical signals of these parts can be collected.

[0059] In one embodiment of the present application, the stimulated biological tissue can be the patient's brain tissue, and the stimulated part can be a specific part of the brain tissue. When the patient's disease type is different, the stimulated part is generally different. The present application does not limit the applicable disease type, which can be deep brain stimulation (DBS), spinal cord stimulation (SCS), pelvic stimulation, gastric stimulation, peripheral nerve stimulation, and functional electrical stimulation. The disease types that DBS can be used to treat or manage include but are not limited to: spastic diseases (e.g., epilepsy), pain, migraine, mental illness (e.g., major depressive disorder (MDD)), bipolar disorder, anxiety, post-traumatic stress disorder, mild depression, obsessive-compulsive disorder (OCD), behavioral disorders, emotional disorders, memory disorders, mental state disorders, movement disorders (e.g., essential tremor or Parkinson's disease), Huntington's disease, Alzheimer's disease, drug addiction, autism or other neurological or psychiatric diseases and damage. When DBS is used to treat drug addiction patients, it can help drug addicts quit drugs and improve their sense of well-being and quality of life.

[0060] In one embodiment of the present application, Figure 1 and Figure 2 As shown, the neural stimulation electrode 10 further includes an axis component 103. The axis component 103 is disposed inside the electrode housing 101 and extends along the axial direction of the electrode housing 101. Preferably, in one embodiment of the present application, the axis component 103 is configured to coincide with the central axis of the electrode housing 101. In one embodiment of the present application, the stimulation head end 102 is connected to the axis component 103 to rotate around the axial direction of the electrode housing 101 (for example, the central axis of the axis component 103 itself), thereby achieving circumferential rotation along the electrode housing 101. There is no particular restriction on the material of the axis component 103.

[0061] The present application does not limit the manner in which the stimulation head end 102 conducts electrical stimulation energy and collects electrical signals, which can be exemplarily achieved through the same set of electrodes, or through two sets of electrodes that are separately arranged. The single electrode used in the present application can conduct electrical stimulation energy and / or collect electrical signals. The collected electrical signals can be single-cell electroencephalogram signals, local field potential (LFP) electroencephalogram signals, or both of the above signals.

[0062] See also Figure 3 , Figure 3A schematic diagram of the structure of a stimulation head end 102 provided in an embodiment of the present application is shown. In one embodiment of the present application, the stimulation head end 102 may include a stimulation contact 1021 and a signal collection contact 1022. There is no particular restriction on the specific materials of the stimulation contact 1021 and the signal collection contact 1022. Specifically, in one embodiment of the present application, the stimulation contact 1021 is used to conduct electrical stimulation energy to the tissue surface to electrically stimulate the tissue, and the signal collection contact 1022 is used to collect electrical signals of the tissue in the body.

[0063] See also Figure 4 and Figure 5 , Figure 4 1 shows a stereoscopic view of another stimulation head end 102 and shaft component 103 provided in an embodiment of the present application. Figure 5 FIG. 1 shows a stereoscopic view of another stimulation head end 102 and shaft component 103 provided in an embodiment of the present application. As can be seen, Figure 4 Two stimulation heads 102 are disposed on the central axis component 103, and the angle between the two stimulation heads 102 is 60 degrees. In other embodiments, when two stimulation heads 102 are disposed on the axis component 103, the angle between the two can be 15 degrees, 30 degrees, 45 degrees, 90 degrees, 120 degrees, 180 degrees, etc., which is not limited in the embodiments of the present application. Figure 5 There are 15 stimulation heads 102, and the 15 stimulation heads 102 are arranged in a circular array of 5 rows and 3 columns. The embodiment of the present application does not limit the arrangement of the plurality of stimulation heads 102, which can be evenly distributed on the shaft component 103 or unevenly distributed.

[0064] As described above, in some embodiments of the present application, the number of stimulation head ends 102 may be 1, and in other embodiments, the number of stimulation head ends 102 may be greater than 1. Each stimulation head end 102 may be provided with a stimulation contact 1021, or each stimulation head end 102 may be provided with more than 1 mutually insulated stimulation contacts 1021. There is no particular restriction on the specific number of the total stimulation contacts 1021, and the number is, for example, 1, 2, 3, 4, 6, 8, 12, 16, 24, 36, etc. There is no particular restriction on the specific shape of the stimulation contact 1021, for example, it may be at least one of an ellipse, a circle, a rounded rectangle, a rectangle, a triangle, and a ring. In addition, there is no particular restriction on the specific shape of the signal acquisition contact 1022.

[0065] In an actual application, the number of the signal collection contacts 1022 is the same as the number of the stimulation contacts 1021 , and each signal collection contact 1022 is disposed at the center position of the stimulation contact 1021 in a one-to-one correspondence.

[0066] It should be noted that the signal collection contacts 1022 and the stimulation contacts 1021 are insulated from each other, that is, in the embodiment of the present application, any two signal collection contacts 1022 are insulated from each other, any two stimulation contacts 1021 are insulated from each other, and any signal collection contact 1022 and any stimulation contact 1021 are insulated from each other.

[0067] See also Figure 6 , Figure 6 A stereoscopic diagram of another stimulation head end 102 and an axis component 103 provided in an embodiment of the present application is shown. Among them, the number of stimulation head ends 102 is 8, and each stimulation head end 102 is provided with 1 stimulation contact 1021 and 1 signal acquisition contact 1022, so that the number of signal acquisition contacts 1022 and the number of stimulation contacts 1021 are both 8. The stimulation contacts 1021 are composed of 4 annular structures of the same diameter arranged in sequence along the axial direction, the first and the last annular structures are composed of 1 annular electrode, and the middle two annular structures are respectively composed of 3 segmented electrodes (respectively located on 3 stimulation head ends 102) arranged at intervals along the circumference of the electrode shell 101. At this time, the stimulation head end 102 can be a shape corresponding to the stimulation contact 1021, for example, a ring.

[0068] See also Figure 6 and Figure 7 , Figure 7 FIG. 1 shows a stereoscopic view of another stimulation head end 102 and shaft component 103 provided in an embodiment of the present application. When the stimulation head end 102 is annular in shape, the connection portion between the stimulation head end 102 and the shaft component 103 may be provided with one (e.g. Figure 6 As shown), multiple (such as Figure 7 As shown, multiple connecting parts are arranged to be evenly distributed along the circumference of the electrode shell 101). When multiple connecting parts are evenly distributed along the circumference of the electrode shell 101 are arranged, deformation of the shaft component 103 caused by uneven force can be avoided, thereby improving the service life of the entire neural stimulation electrode 10.

[0069] See also Figure 8 , Figure 8 The schematic diagram of the structure of an electrode shell 101 provided in an embodiment of the present application is shown. In some optional embodiments, the electrode shell 101 includes a honeycomb-shaped insulating portion 1011 and a plurality of conductive portions 1012 separated by the insulating portion 1011, any two conductive portions 1012 are insulated from each other, and at least two stimulation heads 102 are in contact with different conductive portions 1012, respectively.

[0070] It should be noted that the honeycomb shape in the embodiments of the present application refers to a porous shape. The present application does not limit the number, shape, and size of the holes. The number of holes can be 3, 5, 8, 16, 24, 32, 100, 1000, 10000, etc. The shape of each hole can be circular, such as Figure 8 As shown, it may also be an ellipse, a rounded rectangle, a rectangle, a triangle, a ring, a regular pentagon, a regular hexagon, a regular octagon, etc. The shapes of the multiple holes may be the same or different.

[0071] The plurality of conductive parts 1012 are disposed in the plurality of holes of the honeycomb-shaped insulating part 1011. The number of the conductive parts 1012 can be the same as the number of the holes. The electrode housing 101 can form a relatively closed environment to separate the contact between the internal tissue of the organism and the stimulation head 102.

[0072] The present application does not limit the materials of the insulating part 1011 and the conductive part 1012. The material of the insulating part 1011 is, for example, parylene or other silicon-based materials, and the material of the conductive part 1012 is, for example, one or more of copper, tin, silver, gold and platinum.

[0073] Therefore, the honeycomb-shaped insulating part 1011 is provided to provide mutual insulation conditions for the multiple conductive parts 1012, and the wire function of the traditional nerve stimulation electrode (conducting electrical stimulation, transmitting the collected electrical signals) is realized by at least two stimulation heads 102 contacting different conductive parts 1012 respectively. Compared with the traditional nerve stimulation electrode that needs to use multiple wires to realize the interactive function between multiple electrodes and the pulse generator, only the movable stimulation head end 102 is required to cooperate with the fixed electrode shell 101 to play an interactive role, avoiding the sharp increase in process cost and maintenance cost due to too many wires. Each stimulation head end 102 is connected to the pulse generator respectively, and when used, the stimulation head end 102 can reach any position (through the corresponding conductive part 1012 to realize the conduction between the stimulation head ends 102), so as to realize the doctor's needs of stimulating and collecting various parts of the patient's body tissue.

[0074] See also Fig. 9 , Fig. 9A schematic diagram of the structure of another electrode shell 101 provided in an embodiment of the present application is shown. In some optional embodiments, the electrode shell 101 includes a honeycomb-shaped insulating portion 1011 and a plurality of semiconductor portions 1013 separated by the insulating portion 1011, any two semiconductor portions 1013 are insulated from each other, each semiconductor portion 1013 has a control end, a first connection end, and a second connection end, the first connection end of each semiconductor portion 1013 is connected to the signal transmission end to conduct the electrical stimulation energy or collect the electrical signal, and the second connection end of each semiconductor portion 1013 extends to the tissue;

[0075] At least two stimulation heads 102 are respectively in contact with control ends of different semiconductor parts 1013 to switch on and off the first connection end and the second connection end of the semiconductor part 1013 in contact.

[0076] Semiconductors are materials with electrical conductivity between conductors and insulators at room temperature. Common semiconductor materials include silicon (Si), germanium (Ge), compound semiconductors such as gallium arsenide (Gas), etc., doped or made into other compound semiconductor materials such as boron (B), phosphorus (P), indium (In) and antimony (Sb). Among them, silicon is the most commonly used semiconductor material. Semiconductors usually have the following characteristics:

[0077] 1. The conductivity of semiconductors is between conductors and insulators;

[0078] 2. When semiconductors are stimulated by external light and heat, their conductivity will change significantly;

[0079] 3. If a trace amount of impurities is added to a pure semiconductor, its conductivity will increase dramatically.

[0080] The present application does not limit the components selected for the semiconductor part 1013, which can be a single triode, MOS tube, JFET, etc., or a circuit including a triode, MOS tube or JFET. MOS tube, that is, metal-oxide semiconductor field effect transistor, referred to as metal-oxide-semiconductor field-effect transistor (MOSFET). JFET refers to junction field effect transistor (JFET). For a triode, the control end can be its base, and the first connection end and the second connection end can be its emitter and collector; for a MOS tube and a JFET, the control end can be its gate, and the first connection end and the second connection end can be its source and drain. For the above-mentioned various semiconductor parts 1013, the first connection end and the second connection end can be turned on and off by inputting different electrical signals to its control end.

[0081] Therefore, the honeycomb-shaped insulating part 1011 is provided to provide mutual insulation conditions for the multiple semiconductor parts 1013, and the wire function of the traditional nerve stimulation electrode (conducting electrical stimulation, transmitting the collected electrical signals) is realized by at least two stimulation heads 102 contacting different semiconductor parts 1013 respectively. Compared with the traditional nerve stimulation electrode that needs to use multiple wires to realize the interactive function between multiple electrodes and the pulse generator, only the movable stimulation head end 102 is required to cooperate with the fixed electrode shell 101 to play an interactive role, avoiding too many wires causing a sharp increase in process costs and maintenance costs. Each stimulation head end 102 is connected to the pulse generator respectively, and when used, the stimulation head end 102 can reach any position (through the corresponding semiconductor part 1013 to realize the conduction between the stimulation head ends 102), so as to realize the doctor's needs of stimulating and collecting various parts of the patient's body tissue.

[0082] See also Fig.10 , Fig.10 A schematic structural diagram of a neurostimulation device 1 provided in an embodiment of the present application is shown. The present application also provides a neurostimulation device 1. In one embodiment of the present application, the neurostimulation device 1 includes at least one neurostimulation electrode 10 of the present application. During surgery, electrical stimulation of the tissue of the organism is achieved by implanting the neurostimulation electrode 10 of the neurostimulation device 1 into the tissue of the organism and providing electrical stimulation energy to the neurostimulation electrode 10. In one embodiment of the present application, the neurostimulation device 1 also includes a drive unit 11, which is used to drive the movement of the stimulation head 102 in the electrode housing 101 (including forward and backward movement and rotational movement). There is no particular limitation on the specific form of the drive unit 11, for example, it can be a super micro motor. In one embodiment of the present application, the neurostimulation device 1 also includes a power supply unit 12, which is used to power the drive unit 11.

[0083] In some embodiments, the drive unit 11 can be a very small micro motor, such as the millimeter-level electromagnetic micro motor disclosed in patent CN1048365C, or a micro piezoelectric single crystal linear motor disclosed in patent CN101860257B, or a stepping micro piezoelectric motor disclosed in patent CN207603477U.

[0084] It should be noted that the shaft component 103 can be driven to rotate by the driving unit 11 . In some embodiments, the shaft component 103 can be integrated or formed integrally with the base or output shaft of the driving unit 11 .

[0085] In some embodiments, the nerve stimulation device 1 may further include a gear box (not shown) disposed between the driving unit 11 and the shaft component 103. The gear box may be provided with one or more gears to provide transmission and speed regulation functions.

[0086] Continue to see Fig.10 In one embodiment of the present application, the neurostimulation device 1 may further include a control unit 13. The control unit 13 controls the drive unit 11 to move the stimulation head end 102. The control unit 13 can also control the stimulation head end 102 to supply electrical stimulation energy. In addition, in one embodiment of the present application, the control unit 13 can also analyze the electrical signal collected by the signal acquisition contact 1022, and then further adjust the position of the stimulation head end 102 according to the analysis results, so as to achieve precise stimulation. Specifically, when the control unit 13 finds that the electrical signals in some parts are stronger and the electrical signals in other parts are relatively mild according to the analysis results, the control unit 13 can control the drive unit 11 to move the stimulation head end 102 to the part where the electrical signal is stronger, so as to achieve precise stimulation. Among them, the strong electrical signal means that the collected electrical signal meets one or more of the following conditions: the electrical signal strength is greater than the preset strength; the electrical signal waveform conforms to the preset waveform; the electrical signal pulse width is within the preset pulse width range.

[0087] Since the neural stimulation electrode 10 of the present application can achieve 360-degree circumferential electrical stimulation energy conduction, it is possible to accurately locate the part where the electrical signal is strong, which is impossible to achieve with the technical route of circumferentially setting a limited number of segmented electrodes.

[0088] For example, Fig.11 As shown, Fig.11The schematic diagram of the structure of a slice electrode provided by the prior art is shown. The prior art provides a technical route for stimulation and collection using slice electrodes. If three slice electrodes are set in the circumferential direction, the stimulation range corresponding to a single electrode is approximately a 120-degree fan-shaped area, and if four electrodes are set, the stimulation range corresponding to a single electrode is 90 degrees, and if six electrodes are set, the stimulation range corresponding to a single electrode is 60 degrees. The more slice electrodes are set in the circumferential direction, the more complex the process and the processing and manufacturing cost will rise sharply, and the product yield will also decrease accordingly, which is not conducive to the large-scale promotion and application of the product. However, using the neural stimulation electrode 10 of the present application, it is not necessary to achieve precise stimulation by setting multiple slice electrodes in the circumferential direction. When programmed, the stimulation head end 102 can be controlled to move in the axial and circumferential directions after being implanted in the patient's body, stimulate the tissue in real time, collect electrical signals, and artificially explore the parts with strong electrical signals (or the posture of the stimulation head end 102) or intelligently analyze the parts with strong electrical signals (or the posture of the stimulation head end 102) through software algorithms, so as to help doctors locate the best parts suitable for treatment. Among them, posture refers to position information and posture information.

[0089] An embodiment of the present application also provides a neural stimulation system, which includes any one of the above-mentioned neural stimulation devices.

[0090] According to the neural stimulation system of the present application, it is possible to electrically stimulate different parts of biological tissue using fewer stimulation contacts, and to achieve precise stimulation by collecting and analyzing electrical signals from different parts.

[0091] This application is explained from the perspectives of purpose of use, effectiveness, progress and novelty, and has met the functional enhancement and usage requirements emphasized by the Patent Law. The above description and drawings of this application are only the preferred embodiments of this application, and are not intended to limit this application. Therefore, all structures, devices, features, etc. that are similar or identical to this application, that is, all equivalent replacements or modifications made in accordance with the scope of the patent application of this application, should fall within the scope of protection of the patent application of this application.

Claims

1. A neural stimulation electrode, characterized in that: The neural stimulation electrode comprises: an electrode housing, the electrode housing being a hollow tube, and A stimulation head end is arranged inside the electrode housing and is used to conduct electrical stimulation energy to the tissue surface to electrically stimulate the tissue and collect electrical signals from the tissue. Wherein, the stimulation head end can move in the electrode shell along the axial direction of the electrode shell, and / or the stimulation head end can rotate in the electrode shell along the circumferential direction of the electrode shell; The electrode shell includes a honeycomb-shaped insulating part and a plurality of conductive parts separated by the insulating part. The plurality of conductive parts are arranged in a plurality of holes of the honeycomb-shaped insulating part. Insulation is maintained between any two conductive parts. The stimulation head end realizes stimulation and collection through any conductive part.

2. The neural stimulation electrode according to claim 1, characterized in that: The nerve stimulation electrode further comprises an axis component, which is arranged inside the electrode shell and extends along the axial direction of the electrode shell. Wherein, the stimulation head end is connected to the shaft component and can rotate around the axial direction of the electrode shell, so that the stimulation head end can rotate along the circumferential direction of the electrode shell.

3. The neural stimulation electrode according to claim 1, characterized in that The stimulation head end comprises: a stimulation contact for transmitting electrical stimulation energy to the surface of the tissue to electrically stimulate the tissue, and A signal collection contact is used to collect the electrical signal.

4. The neural stimulation electrode according to claim 3, characterized in that: The shape of the stimulation contact is at least one of an ellipse, a circle, a rounded rectangle, a rectangle, a triangle and a ring.

5. The neural stimulation electrode according to claim 3, characterized in that: The number of the stimulation heads is greater than one.

6. The neural stimulation electrode according to claim 5, characterized in that: At least two stimulation heads are respectively in contact with different conductive parts.

7. The neural stimulation electrode according to claim 5, characterized in that: The conductive part is a semiconductor part, each semiconductor part has a control end, a first connection end and a second connection end, the first connection end of each semiconductor part is connected to the signal transmission end to conduct the electrical stimulation energy or collect the electrical signal, and the second connection end of each semiconductor part extends to the tissue; At least two stimulation heads are respectively in contact with control terminals of different semiconductor parts, and are used to turn on and off the first connection terminal and the second connection terminal of the contacted semiconductor parts.

8. The neural stimulation electrode according to claim 1, characterized in that: The types of diseases that the neural stimulation electrodes are used to treat include one or more of epilepsy, tremor, Parkinson's disease, depression, obsessive-compulsive disorder, Alzheimer's disease, autism and drug addiction.

9. A nerve stimulation device, characterized in that: The neural stimulation device comprises at least one neural stimulation electrode according to any one of claims 1-8.

10. The nerve stimulation device according to claim 9, characterized in that The nerve stimulation device further comprises a driving unit, and the driving unit is used to drive the stimulation head end to move along the axial direction of the electrode shell and to rotate along the circumferential direction of the electrode shell.

11. The nerve stimulation device according to claim 9, characterized in that The neural stimulation device also includes a control unit, which is used to analyze the electrical signal and move the stimulation head according to the analysis result of the electrical signal to achieve precise stimulation.

12. A neural stimulation system, characterized in that: The neural stimulation system comprises the neural stimulation device according to any one of claims 9 to 11.

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