Isotropic concentrate and cleaning composition

Abstract

The present invention relates to an isotropic concentrate composition that is easily hydrated and converted into an end-use cleaning composition. The end-use cleaning composition obtained from the concentrate composition is suitable for topical application and hand washing. The concentrate contains a fragrance oil and an emulsifier at levels that unexpectedly result in the concentrate composition and the end-use composition being free of precipitation of ingredients that interfere with the appearance and use of the composition.

Description

Technical Field

[0001] The present invention relates to an isotropic concentrate composition that is easily hydrated and converted into an end-use cleaning composition. The end-use cleaning composition obtained from the concentrate composition is suitable for topical application and for washing, especially hands. In particular, the present invention relates to a composition that is preferably sulfate-free in at least one embodiment and is gentle when used. In addition, the end-use composition made from the concentrate is unexpectedly capable of significant foaming, is stable and also has a micellar (isotropic) microstructure. The concentrate contains a fragrance oil and an emulsifier at levels that unexpectedly result in the concentrate composition and the end-use composition being free of any precipitation of ingredients that interfere with the appearance and use of the composition. This end-use composition also provides excellent sensory benefits. Background Art

[0002] Consumers seek personal cleansing compositions that are preferably sulfate-free (i.e., free of sulfate-based surfactants) and are mild and moisturizing while providing excellent sensory benefits, such as pleasant lather and soft, smooth skin, even after a single wash. This is especially true when washing hands, as consumers are encouraged to wash their hands frequently to avoid illness.

[0003] In addition to this, conscious consumers are looking for opportunities to reduce environmental waste, and particularly waste related to plastics, as people are often told that the world's oceans will soon have more plastic than fish. In view of environmental issues and the desire of consumers and conscious companies to do more for the earth, there is a strong desire to reduce the use of plastics when selling products, including consumer products. Therefore, efforts have been made to sell products in concentrated form and to ship products with less water included in them. The difficulty with concentrates is that consumers generally do not like to add additional water to the concentrate and further manipulation, such as stirring, to convert the concentrate into a final usable product. For hydrated products, common complaints include that the product is time-consuming to prepare, is uneven and granular, and can precipitate after adding water and during use.

[0004] There is increasing interest in developing an easy-to-use and easily hydrating concentrate with a refillable package. It is also desirable to provide consumers with a product that is ready to use within five (5) minutes and provides a pleasing organoleptic profile without a grainy feel. The concentrates and end-use compositions of the present invention comprise acyl isethionates. These surfactants are known to be mild surfactants. However, compositions containing high levels of acyl isethionates and other surfactants often exhibit precipitation of ingredients (e.g., crystallization), which often results in an end-use composition that is undesirable for consumer use. Accordingly, the present invention is directed to an isotropic concentrate composition suitable for dilution into an end-use cleaning composition that is also isotropic. The concentrate composition comprises a fragrance oil and an emulsifier at levels that unexpectedly result in an end-use composition that is free of precipitation of ingredients upon dilution, i.e., when formulated using acyl isethionates.

[0005] Additional Information

[0006] Efforts to prepare cleaning compositions have been disclosed. In Sun et al. (Journal of Cosmetic Science, 54, 559-568, 2003), cleaning compositions containing acyl isethionates and other surfactants such as methyl acyl taurates, acyl glutamates, acyl lactylates, alkyl ethers and dialkyl sulfosuccinates and acyl sarcosinates are described.

[0007] Even other efforts to prepare cleaning compositions have been disclosed. In US Pat. No. 5,415,810 to Lee et al., cleaning solutions containing acyl isethionates are disclosed which also contain other anionic surfactants such as methyl acyl taurates.

[0008] Other efforts to prepare cleaning compositions have also been disclosed. In US Pat. No. 5,925,603 to D'Angelo, the use of methyl acyl taurates and acyl isethionates is disclosed.

[0009] Further efforts to prepare washing compositions have been described. In WO1992020776A1 and EP0133345A1, liquid hand soap compositions are described. In US6,117,828, hand washing compositions containing wheat protein are described.

[0010] None of the additional information describes the concentrated compositions or end-use compositions claimed herein. Summary of the invention

[0011] In a first aspect, the present invention relates to an isotropic concentrate composition comprising:

[0012] 1) 0.1 to 10%, preferably 0.5 to 6%, more preferably 1 to 4.5% by weight of acyl isethionate;

[0013] 2) 0.1 to 10%, preferably 0.5 to 6%, more preferably 1 to 4.5% by weight of acyl taurate;

[0014] 3) 0.2 to 25%, preferably 3.0 to 20% and more preferably 5 to 17% by weight of amphoteric and / or zwitterionic surfactants;

[0015] 4) 5.0 to 50%, preferably 10.0 to 40%, more preferably 20 to 30% by weight of a humectant comprising glycerol;

[0016] 5) 0.7 to 8%, preferably 1.0 to 7%, more preferably 1.5 to 5% by weight of fragrance;

[0017] 6) 0.7 to 5%, preferably 1.0 to 4.5%, more preferably 1.2 to 4% by weight of an emulsifier having an HLB of 8 to 19, preferably 10 to 18, more preferably 12 to 17; and

[0018] 7) 25 to 80%, preferably 30 to 70%, more preferably 35 to 45% by weight of water,

[0019] wherein the total surfactant constitutes 12 to 35%, and preferably 15 to 30%, and most preferably 20 to 28% by weight of the isotropic concentrate composition, and further wherein the emulsifier and fragrance are in a weight ratio of emulsifier to fragrance of 1:0.8 to 1:4, preferably 1:1 to 1:3, and more preferably 1:1.1 to 1:2.

[0020] In a second aspect, the present invention relates to an end-use composition obtained by hydrating the isotropic concentrate composition of the first aspect of the present invention, wherein the weight ratio of the isotropic concentrate composition to added water is from 1:1 to 1:6, preferably from 1:1.5 to 1:5, most preferably from 1:2 to 1:4.

[0021] In a third aspect, the present invention relates to the use of the end-use composition as a hand washing composition, preferably a hand washing composition dispensed from a refillable package, and more preferably from a refillable package suitable for dispensing a hand washing composition in foam form.

[0022] As used herein, "composition" without qualifiers means the isotropic concentrate compositions and end-use compositions of the present invention. As used herein, hydratable means adding and / or adding and uniformly absorbing water to a composition having water (such as a composition that is initially 25 to 80% by weight of water) (i.e., diluting). No precipitation of ingredients means that there is no visible precipitation or crystal formation in the end-use composition of the present invention (and there is no graininess when the composition is applied to the skin) at least 1-3 days after mixing, preferably 2-3 days after mixing and forming the end-use composition. As used herein, skin means skin including arms (including underarms), face, feet, neck, chest, hands, legs, buttocks and scalp (including hair). An isotropic concentrate composition ("isotropic concentrate") refers to an isotropic composition to which the viscosity does not increase when water is added, so as to produce a lower viscosity end-use composition that is also isotropic and suitable for topical application. An isotropic concentrate is a composition that generally has a viscosity of 30 to 6,500 cps before hydration. The end-use composition is a composition suitable for wiping or washing off, and preferably a composition washed off with water. The end-use composition may be a home care cleaning composition, but is preferably a shampoo, a makeup remover, a facial cleanser, a hand soap, or a personal care liquid body wash. The end-use composition may optionally contain a medicinal or therapeutic agent, but is preferably a cosmetic and non-therapeutic detergent. In one embodiment of the present invention, the end-use composition is a home care composition, such as a desktop or toilet cleaning composition. In another embodiment, the end-use composition is a shampoo composition. In another embodiment, the end-use composition is preferably a personal washing composition, and especially a liquid hand soap that is self-foaming and dispensed from a refillable package. As described below, the end-use composition of the present invention may optionally contain skin benefit ingredients added thereto, such as emollients, vitamins and / or derivatives thereof, resorcinols, retinoic acid precursors, colorants, moisturizers, sunscreens, mixtures thereof, etc. The skin benefit ingredients (or agents) may be water-soluble or oil-soluble. If used, oil-soluble skin benefit agents typically comprise 1.5% by weight of the final use composition, while water-soluble skin benefit agents, when used, typically comprise 10% by weight of the final use composition of the present invention. Isotropic concentrates and final use compositions typically have a pH of 4.5 to 10. Unless otherwise stated, viscosities were measured using a Discovery HR-2 Rheometer using a sandblasted plate with a 100 micron gap and 4-15 s -1The viscosity is measured at a shear rate. The viscosity is measured at 25°C. The reduction in viscosity means that the initial viscosity of the isotropic concentrate of the present invention is higher than the final viscosity after adding water and preparing the resulting end-use composition. The end-use composition is prepared by combining water and the isotropic concentrate and mixing them (with moderate shear, such as stirring, preferably shaking) to produce an end-use composition having a viscosity lower than that of the isotropic concentrate used to prepare it. Typically, the end-use composition (such as a hand washing composition) will have a viscosity of 0.0 to 650 cps. In another embodiment, the isotropic concentrate can be applied directly to, for example, a consumer, and when water and shear are applied (such as, for example, sheared by hand and water from a sink or shower), the desired end-use composition (i.e., hand soap or body wash) can be prepared. As used herein, "substantially free of sulfates" means less than 6.0% by weight of the end-use composition, and "substantially free of oil" means less than 0.3% by weight of the end-use composition, wherein the oil does not refer to or include any perfume oil. The term "comprising" is intended to encompass the terms "consisting essentially of" and "consisting of". For the avoidance of doubt, and for the purpose of illustration, the end-use compositions of the present invention comprising surfactants, water and active substances are intended to include compositions consisting essentially of and consisting of. All ranges defined are intended to include all ranges contained therein. Except in the operating comparative examples, or where otherwise explicitly indicated, all numbers in this specification representing amounts or ratios of materials or conditions and / or physical properties of materials and / or uses should be understood to be modified by the word "about". DETAILED DESCRIPTION

[0023] The isotropic concentrate composition of the present invention will have a viscosity of 30 to 6,500 cps, and preferably 50 to 3,000 cps, and most preferably 100 to 1,500 cps, including all ranges contained therein. With respect to the final use composition, its viscosity is 0.0 to 650 cps, preferably 0 to 500 cps, and most preferably 0 to 250 cps, including all ranges contained therein. The viscosity of the final use composition ensures that the composition can be discharged from a pump dispenser, especially a dispenser that dispenses foam, without clogging problems. Surprisingly, at such a viscosity, the final use composition is easy to discharge from the dispenser while surprisingly delivering excellent sensory benefits to consumers.

[0024] With respect to anionic surfactants, the total amount thereof is typically from 0.15 to 30% by weight of the isotropic concentrate, including all ranges subsumed therein. In one embodiment of the invention, the total amount of anionic surfactants is from 0.5 to 16% by weight of the isotropic concentrate, preferably from 0.8 to 9% by weight, including all ranges subsumed therein. In another embodiment of the invention, the acyl isethionates and acyl taurates used constitute 75 to 100%, preferably 80 to 100%, and most preferably 85 to 100% by weight of the total amount of anionic surfactants used in the composition of the invention. In an optional embodiment of the invention, in addition to the acyl isethionates and acyl taurates (both of which may contain C on their head groups), 1-4 In addition to the alkyl substituents, especially methyl, the total amount of anionic surfactants in the compositions of the invention may comprise from 0.01 to 7% by weight of acyl glycinates.

[0025] With respect to the amphoteric and / or zwitterionic surfactants used in the isotropic concentrate, they typically comprise from 0.2 to 25%, and preferably from 3 to 20%, and most preferably from 5 to 17% by weight of the isotropic concentrate, including all ranges subsumed therein.

[0026] To aid in the structuring and hydration of the isotropic concentrate, for example, it may be preferred to use a structuring agent such as C6-C 18 Acid and / or alcohol (i.e., derivatives thereof), and typically comprises 0.1 to 3% by weight of the isotropic concentrate, and preferably 0.2 to 2%, and most preferably 0.4 to 1.5% by weight, including all ranges subsumed therein. Preferred structuring agents are myristic acid, lauric acid, stearic acid, or any alcohol derivative thereof, or mixtures thereof. In one embodiment of the invention, the structuring agent comprises lauric acid and stearic acid, and the weight ratio of lauric acid to stearic acid is 1:1 to 1:5, preferably 1:1 to 1:4, and most preferably 1:1 to 1:3, including all ratios subsumed therein.

[0027] Inorganic salts are optional ingredients useful in aiding in the delivery of the sensory characteristics of the composition. Typical salts that may be used include NaCl, KCl, MgCl2, CaCl2, mixtures thereof, and the like. Typically, the inorganic salt comprises 0 to 8%, and preferably 0 to 6%, and most preferably 0.001 to 2% by weight of the isotropic concentrate, including all ranges subsumed therein.

[0028] Polymeric viscosity aids are optional ingredients suitable for use in the isotropic concentrates of the present invention. If used, preferred polymers are those generally classified as high molecular weight ethoxylated fatty acid esters. Illustrative examples include PEG 120 methyl glucose dioleate, PEG 18 glyceryl oleate / cocoate, PEG 150 pentaerythritol tetrastearate, mixtures thereof, and the like. A generally preferred polymeric viscosity aid is PEG 150 pentaerythritol tetrastearate, which is sold by Croda under the name Versathix. If used, these aids comprise from 0.001 to 0.5%, preferably from 0.001 to 0.3%, and most preferably from 0.01 to 0.2% by weight of the isotropic concentrate, including all ranges subsumed therein.

[0029] In another embodiment of the invention, less than 3.0 wt. % sulfate is present in the end-use composition of the invention, preferably less than 1.0 wt. %, and most preferably no sulfate is present (0.0 wt. %). Thus, the isotropic concentrate should be formulated such that upon dilution, the ingredient (e.g., sulfate) is at the desired level in the end-use composition.

[0030] With respect to anionic surfactants suitable for use in the isotropic concentrates and end-use compositions of the present invention (i.e., when not only acyl isethionates and acyl taurates are used), the anionic surfactants used may include aliphatic sulfonates, such as primary alkanes (e.g., C8-C 22 ) sulfonates, primary alkanes (e.g., C8-C 22 ) disulfonate, C8-C 22 Olefin sulfonates, C8-C 22 Hydroxyalkane sulfonate or alkyl glyceryl ether sulfonate (AGS); or aromatic sulfonate, such as alkylbenzene sulfonate. The anionic surfactant can also be an alkyl sulfate (e.g. C 12 -C 18 Alkyl sulfates) or alkyl ether sulfates (including alkyl glyceryl ether sulfates). Alkyl ether sulfates include those having the formula:

[0031] RO(CH2CH2O) n SO3M

[0032] wherein R is an alkyl or alkenyl group having 8 to 18 carbons, preferably 12 to 18 carbons, n has an average value of at least 1.0, preferably less than 5, and most preferably 1 to 4, and M is a solubilizing cation such as sodium, potassium, ammonium or substituted ammonium.

[0033] The anionic surfactant may also include alkyl sulfosuccinates (including monoalkyl and dialkyl, such as C6-C 22sulfosuccinates); alkyl and acyl taurates (usually methyl taurates), alkyl and acyl sarcosinates, sulfoacetates, C8-C 22 Alkyl phosphates and phosphonates, alkyl phosphate esters and alkoxyalkyl phosphate esters, acyl lactylates, C8-C 22 Monoalkyl succinates and maleates, sulfoacetates, alkyl glucosides and acyl isethionates, etc.

[0034] The sulfosuccinate may be a monoalkyl sulfosuccinate having the formula:

[0035] R 1 O2CCH2CH(SO3M)CO2M

[0036] and the amide-MEA sulfosuccinate of the formula:

[0037] R 1 CONHCH2CH2O2CCH2CH(SO3M)CO2M, where R 1 Range: C8-C 22 alkyl.

[0038] Sarcosinate is generally represented by the following formula:

[0039] R 2 CON(CH3)CH2CO2M, where R 2 Range: C8-C 20 alkyl.

[0040] The taurates used are generally represented by the following formula:

[0041] R 3 CONR 4 CH2CH2SO3M,

[0042] Where R 3 It is C8-C 20 Alkyl, R 4 It is a C1-C4 alkyl group.

[0043] M is a solubilizing cation as previously described.

[0044] Isethionates that can be used include C8-C 18 Acyl isethionates (including those with substituted head groups). These esters are prepared by the reaction of an alkali metal isethionate with mixed aliphatic fatty acids having from 6 to 18 carbon atoms and an iodine value of less than 20. Typically at least 75% of the mixed fatty acids have from 12 to 18 carbon atoms and up to 25% have from 6 to 10 carbon atoms.

[0045] The acyl isethionate used may be an alkoxylated isethionate as described in U.S. Pat. No. 5,393,466, issued Feb. 28, 1995 to Ilardi et al., entitled "Fatty acid esters of polyalkoxylated isethionate," which is incorporated herein by reference. Such compounds have the general formula:

[0046] R 5 C--O(O)--C(X)H--C(Y)H--(OCH2--CH2) m --SO3M

[0047] Where R 5 is an alkyl group having 8 to 18 carbons, m is an integer from 1 to 4, X and Y are each independently hydrogen or an alkyl group having 1 to 4 carbons, and M is a solubilizing cation as described above.

[0048] In one embodiment of the present invention, the anionic surfactant used is sodium lauroyl glycinate, sodium cocoyl glycinate, sodium lauroyl glutamate, sodium cocoyl glutamate, sodium lauroyl isethionate, sodium cocoyl isethionate, sodium methyl lauroyl taurate, sodium methyl cocoyl taurate or a mixture thereof. Such anionic surfactants are commercially available from suppliers such as Galaxy Surfactants, Clariant, Sino Lion and Innospec. Sodium cocoyl isethionate, sodium methyl lauroyl taurate, sodium methyl lauroyl isethionate or a mixture thereof are preferred anionic surfactants suitable for use.

[0049] Suitable amphoteric surfactants for use in the present invention (which may be zwitterionic depending on the pH) include sodium acylamphoacetate, sodium acylamphopropionate, disodium acylamphodiacetate and disodium acylamphodipropionate, wherein the acyl group (i.e., alkanoyl) may contain C7-C 18 Alkyl moiety. Illustrative examples of suitable amphoteric surfactants include sodium lauroamphoacetate, sodium cocoamphoacetate, sodium lauroamphoacetate, sodium cocoamphoacetate, and mixtures thereof.

[0050] With regard to zwitterionic surfactants useful in the present invention, such surfactants include at least one acid group. Such acid groups may be carboxylic acid or sulfonic acid groups. They typically include quaternary nitrogen and thus may be quaternary amino acids. They typically should include alkyl or alkenyl groups of 7 to 18 carbon atoms and typically conform to the overall structural formula:

[0051] R 6 --[--C(O)--NH(CH2) q --] r --N + --(R 7--)(R 8 )A--B, where R 7 is an alkyl or alkenyl group of 7 to 18 carbon atoms; R 7 and R 8 Each is independently an alkyl group, a hydroxyalkyl group or a carboxyalkyl group having 1 to 3 carbon atoms; q is 2 to 4; r is 0 to 1; A is an alkylene group having 1 to 3 carbon atoms optionally substituted by a hydroxy group, and B is --CO2-- or --SO3--.

[0052] Suitable zwitterionic surfactants for use herein and within the above general formula include simple betaines of the formula:

[0053] R 6 --N + --(R 7 )(R 8 )CH2CO2 -

[0054] and amido betaine of the formula:

[0055] R 6 --CONH(CH2) t --N + --(R 7 )(R 8 )CH2CO2 - , where t is 2 or 3.

[0056] In both formulas, R 6 , R 7 and R 8 As defined above. In particular, R 6 Can be C from coconut oil 12 and C 14 mixture of alkyl groups such that at least half, preferably at least three quarters, of the groups R 6 Has 10 to 14 carbon atoms. 7 and R 8 Preferred is methyl.

[0057] Another possibility is that the zwitterionic surfactant is a sulfobetaine of the formula:

[0058] R 6 --N + --(R 7 )(R 8 )(CH2)3SO3 -

[0059] or

[0060] R 6 --CONH(CH2) u --N+ --(R 7 )(R 8 )(CH2)3SO3 -

[0061] Where u is 2 or 3, or a variation of these, where - (CH2)3SO3 - Replaced by --CH2C(OH)(H)CH2SO3 - .

[0062] In these formulas, R 6 , R 7 and R 8 As defined above.

[0063] Illustrative examples of suitable zwitterionic surfactants include betaines, such as cocodimethyl carboxymethyl betaine, cocamidopropyl betaine, and lauroamidopropyl betaine. Other suitable zwitterionic surfactants include cocamidopropyl sulfobetaine. Such surfactants are commercially available from suppliers such as Stepan Company, and it is within the scope of the present invention to use mixtures of the above surfactants. In a preferred embodiment, the zwitterionic surfactant used in the present invention is cocamidopropyl betaine.

[0064] In one embodiment of the present invention, cationic surfactants may optionally be used in the isotropic concentrates and end-use compositions of the present invention.

[0065] One class of optional cationic surfactants includes heterocyclic ammonium salts such as cetyl or stearyl pyridinium chloride, alkylamidoethylpyrrolyl methyl sulfate and lapyrium chloride.

[0066] Tetraalkylammonium salts are another class of useful cationic surfactants suitable for optional use. Examples include cetyl or stearyl trimethyl ammonium chloride or bromide; hydrogenated palm or tallow trimethyl ammonium halides; behenyl trimethyl ammonium halides or methyl ammonium sulfate; decyl isononyl dimethyl ammonium halides; ditallow (or distearyl) dimethyl ammonium halides and behenyl dimethyl ammonium chloride.

[0067] Other types of cationic surfactants that can be used are various ethoxylated quaternary amines and esterquats. Examples include PEG-5 stearyl ammonium lactylate (e.g., Genamin KSL manufactured by Clariant), PEG-2 cocoyl ammonium chloride, PEG-15 hydrogenated tallow ammonium chloride, PEG 15 stearyl ammonium chloride, dipalmitoyl ethyl methyl ammonium chloride, dipalmitoyl hydroxyethyl methyl sulfate, and stearamidopropyl dimethylamine lactylate.

[0068] Still other useful cationic surfactants suitable for optional use include quaternized hydrolysates of silk, wheat and keratin, and it is within the scope of the present invention to use mixtures of the foregoing cationic surfactants.

[0069] If used, cationic surfactants will comprise no more than 1.0% by weight of the end use composition. If present, they typically comprise from 0.001 to 0.7%, and more typically from 0.01% to 0.5% by weight of the end use composition, including all ranges subsumed therein.

[0070] In one embodiment of the invention, the compositions of the invention will be substantially free of polymeric quaternary ammonium compounds (including salts thereof). In another embodiment, the end-use composition will contain less than 0.1% by weight of polymeric quaternary ammonium compounds. In yet another embodiment, the end-use composition contains less than 0.01% by weight of polymeric quaternary ammonium compounds. In even another embodiment, the isotropic concentrate and the end-use composition contain no polymeric quaternary ammonium compounds (i.e., 0.0%).

[0071] Water preferably comprises from 25 to 80 weight percent of the foregoing isotropic concentrate, including all ranges subsumed therein.

[0072] The pH of the isotropic composition and the final use composition is generally 4.5 to 10, and preferably 5 to 9, and most preferably 5.2 to 7.5, including all ranges contained therein. Adjusters suitable for adjusting / buffering the pH may be used. Such pH adjusters include triethylamine, NaOH, KOH, H2SO4, HCl, C6H8O7 (i.e., citric acid), or mixtures thereof. The pH adjuster is added in an amount that produces the desired final pH. The pH value can be assessed using commercial instruments, such as those available from Thermo The pH meter was commercially available from the company.

[0073] Optional skin benefit agents are suitable for use herein only to the extent that they are capable of being topically applied and are suitably soluble in the hydratable composition and the end use composition at the desired pH.

[0074] Illustrative examples of beneficial agents suitable for inclusion in the water portion of the composition are acids, such as amino acids, such as arginine, valine or histidine. Other water-soluble beneficial agents suitable include vitamin B2, niacinamide (vitamin B3), vitamin B6, vitamin C, and mixtures thereof. Water-soluble derivatives of these vitamins can also be used. For example, vitamin C derivatives, such as ascorbyl tetraisopalmitate, magnesium ascorbyl phosphate and ascorbyl glycosides, can be used alone or in combination with each other. Other water-soluble beneficial agents suitable include 4-ethylresorcinol, extracts such as sage, aloe, green tea, grape seed, thyme, chamomile, yarrow, cucumber, licorice, rosemary extract, or mixtures thereof. Water-soluble sunscreens such as ensolizole can also be used. When present in the present invention, the total amount of optional water-soluble beneficial agents (including mixtures) can be in the range of 0.0 to 10%, preferably 0.001 to 8%, and most preferably 0.01 to 6% by weight, based on the total weight of the final use composition, and including all ranges contained therein.

[0075] It is also within the scope of the present invention to optionally include an oil (i.e., non-water) soluble benefit agent. The end-use composition is substantially free of oil, and preferably has less than 0.15% by weight of oil, and most preferably is free of oil (0.0%). Thus, the oil-soluble active or benefit agent is dissolved in the surfactant used. The only limitation on such oil-soluble benefit agents is that they are suitable for providing a benefit when applied topically.

[0076] Illustrative examples of the types of oil-soluble benefit agents that may be optionally used in the compositions of the present invention include components such as stearic acid, vitamins such as vitamins A, D, E and K (and their oil-soluble derivatives), sunscreens such as ethylhexyl methoxycinnamate, bis-ethylhexyloxyphenol methoxyphenol triazine, 2-ethylhexyl-2-cyano-3,3-diphenyl-2-propionic acid, drometrizole trisiloxane, 3,3,5-trimethylcyclohexyl 2-hydroxybenzoate, 2-ethylhexyl-2-hydroxybenzoate, or mixtures thereof.

[0077] Other optional oil-soluble benefit agents suitable for use include resorcinols, such as 4-hexylresorcinol, 4-phenylethylresorcinol, 4-cyclopentylresorcinol, 4-cyclohexylresorcinol, 4-isopropylresorcinol, or mixtures thereof. In addition, 5-substituted resorcinols, such as 4-cyclohexyl-5-methylbenzene-1,3-diol, 4-isopropyl-5-methylbenzene-1,3-diol, mixtures thereof, etc., can be used. 5-substituted resorcinols and their synthesis are described in commonly assigned U.S. Published Patent Application No. 2016 / 0000669A1.

[0078] More suitable oil-soluble active ingredients include omega-3 fatty acids, omega-6 fatty acids, climbazole, farnesol, ursolic acid, myristic acid, geranylgeraniol, oleyl betaine, cocoyl hydroxyethyl imidazoline, hexanoyl sphingosine, 12-hydroxystearic acid, petroselinic acid, conjugated linoleic acid, terpineol, thymol, mixtures thereof, and the like.

[0079] In one embodiment of the invention, the optional oil-soluble beneficial agent used is a retinoic acid precursor. In one embodiment of the invention, the retinoic acid precursor retinol is retinol, retinal, retinyl propionate, retinyl palmitate, retinyl acetate or a mixture thereof. Retinyl propionate, retinyl palmitate and mixtures thereof are generally preferred.

[0080] Another suitable retinoic acid precursor is provided by Molecular Design International under the name Commercially available hydroxyanasatil retinoic acid can be used in admixture with the oil-soluble active ingredients described herein.

[0081] When the optional (i.e., 0.0 to 1.5% by weight) oil-soluble active is used in the end-use composition of the present invention, it generally comprises 0.001 to 1.5% by weight, and in another embodiment, 0.05 to 1.2% by weight, and in yet another embodiment, 0.1 to 0.5% by weight, based on the total weight of the end-use composition, including all ranges subsumed therein.

[0082] Preservatives may be desirably incorporated into hydratable concentrates and end-use compositions to prevent the growth of potentially harmful microorganisms. Cosmetic chemists are familiar with suitable preservatives and typically select them to meet preservative challenge tests and provide product stability. Suitable conventional preservatives include hydantoin derivatives and propionates. Particularly preferred preservatives are iodopropynyl butylcarbamate, phenoxyethanol, 1,2-octanediol, hydroxyacetophenone, ethylhexylglycerin, hexylene glycol, methylparaben, propylparaben, imidazolidinyl urea, sodium dehydroacetate, dimethyl-dimethyl (DMDM) hydantoin and benzyl alcohol, and mixtures thereof. Other suitable preservatives include sodium dehydroacetate, chlorphenesin and decanediol. The selection of preservatives should take into account the use of the composition and possible incompatibility between the preservative and other ingredients in the emulsion. The preservative is preferably used in an amount ranging from 0.01% to 2.0% by weight of the total weight of the final use composition (up to 7% by weight of the total isotropic concentrate), including all ranges subsumed therein. Also preferred are preservative systems having hydroxyacetophenone alone or in mixture with other preservatives.

[0083] Thickeners are optionally suitable for use in the compositions of the present invention. Particularly useful are polysaccharides. Examples include fibers, starches, natural / synthetic gums, and cellulose products. Representative starches are chemically modified starches, such as hydroxypropyl starch sodium phosphate and starch octenyl succinate aluminum. Tapioca starch is generally preferred, as is maltodextrin. Suitable gums include xanthan gum, sclerotium, pectin, karaya gum, gum arabic, agar, guar gum (including Senegalese gum arabic), carrageenan, alginate, and combinations thereof. Suitable cellulose products include hydroxypropyl cellulose, hydroxypropyl methylcellulose, ethyl cellulose, sodium carboxymethyl cellulose (cellulose gum / carboxymethyl cellulose), and cellulose (e.g., cellulose microfibrils, cellulose nanocrystals, or microcrystalline cellulose). The sources of cellulose microfibrils include secondary cell wall materials (e.g., wood pulp, cotton), bacterial cellulose, and primary cell wall materials. Preferably, the source of primary cell wall material is selected from parenchyma tissue from fruits, roots, bulbs, tubers, seeds, leaves and combinations thereof; more preferably selected from citrus fruit, tomato fruit, peach fruit, pumpkin fruit, kiwi fruit, apple fruit, mango fruit, sugar beet, beetroot, turnip, parsnip, corn, oats, wheat, peas and combinations thereof; and even more preferably selected from citrus fruit, tomato fruit and combinations thereof. The most preferred source of primary cell wall material is parenchyma tissue from citrus fruit. Citrus fiber, such as can be obtained from Those obtained as AQ Plus can also be used as a source of cellulose microfibrils. The cellulose source can be surface modified by any known method, including those described in Colloidal Polymer Science, Kalia et al., "Nanofibrillated cellulose: surface modification and potential applications" (2014), Vol. 292, pp. 5-31.

[0084] In addition to polymeric viscosity building agents, synthetic polymers are another class of effective thickeners that may optionally be used. This class includes cross-linked polyacrylates, such as carbomers, polyacrylamides, such as 305 and taurine copolymer, such as EG and AVC, the copolymers are identified by their respective INCI nomenclature as sodium acrylate / sodium acryloyldimethyl taurate and acryloyldimethyl taurate / vinyl pyrrolidone copolymer. Another preferred synthetic polymer suitable for thickening is an acrylate-based polymer commercially available from Seppic and sold under the name Simulgel INS 100. Calcium carbonate, fumed silica and magnesium aluminum silicate may also be used.

[0085] When used, the optional thickener may be present in amounts of 0.001% to 6% by weight of the composition.Maltodextrin, xanthan gum and carboxymethylcellulose are generally preferred optional thickeners.

[0086] Fixatives, chelating agents (such as EDTA), and exfoliants may optionally be included in the compositions of the present invention. Each of these materials may be present in the range of about 0.03 to about 5%, preferably 0.1 to 3% by weight of the total weight of the final use composition, including all ranges subsumed therein. Where exfoliants are used, those selected should have a sufficiently small particle size so that they do not interfere with the performance of any packaging used to dispense the compositions of the present invention.

[0087] With regard to the emulsifiers used in the present invention, these emulsifiers have an HLB of 8 to 19. Illustrative examples include Tween 40, Tween 60, Tween 80, polysorbate 20 (HLB 16.7), PEG-100 stearate, cocamide MEA, PEG-8 oleate, laureth-23, or mixtures thereof. The emulsifier in the isotropic concentrate of the present invention will comprise 0.7 to 5% by weight of the isotropic concentrate, including all ranges subsumed therein. As used herein, polysorbate 20 is defined herein as an emulsifier and is often a preferred emulsifier in the compositions of the present invention.

[0088] Conventional humectants other than glycerol can be used as additives in the present invention to help moisturize the skin when the final use composition is topically applied. These are generally polyol-type materials. Typical polyols other than glycerol include propylene glycol, dipropylene glycol, polypropylene glycol (e.g., PPG-9), polyethylene glycol, sorbitol, hydroxypropyl sorbitol, hexylene glycol, 1,3-butylene glycol, isopentyl glycol, 1,2,6-hexanetriol, ethoxylated glycerol, propoxylated glycerol, and mixtures thereof. Most preferred are humectants of at least 75% by weight glycerol, based on the total weight of the humectant in the composition. A mixture of propylene glycol and glycerol is generally preferred, wherein the mixture is 5 to 15%, preferably 6 to 12% by weight of propylene glycol based on the total weight of the polypropylene glycol and glycerol in the humectant. In addition to glycerol, the amount of the humectant used can be in the range of 0.0% to 35% by weight of the total weight of the final use composition. Typically, the additional humectant comprises from 0.0 to 20% by weight, and preferably from 0.001 to 15% by weight (most preferably from 2 to 12% by weight), based on the total weight of the end-use composition.

[0089] With respect to the isotropic concentrates of the present invention, they typically have 5 to 50% by weight humectant, including all ranges subsumed therein. In one embodiment of the present invention, at least 85% by weight, and preferably 90 to 100% by weight of the total humectant used in the isotropic concentrates and end-use compositions is glycerol.

[0090] Fragrances used in the present invention include those recognized in the art as being suitable for topical compositions. Such fragrances may include components such as nerolidol, geraniol, terpinolene, linalool, terpinene, limonene, pinene, camphene, citronellol, citronellal, geraniol, vanillin, terpineol, thymol, eugenol, lavender oil, clary sage oil, orange blossom oil, rosemary oil, ginger oil, lemon oil, thyme oil, terpinyl acetate, mixtures thereof, and the like. Unexpectedly, it has been found that when conventional fragrances are used together with emulsifiers as described in the present invention, the isotropic concentrates and end-use compositions of the present invention do not contain precipitation of ingredients. Typically, the isotropic concentrate will contain 0.7 to 8% by weight of fragrance, including all ranges contained therein.

[0091] The present invention relates to isotropic concentrate compositions which decrease in viscosity upon mixing with water.

[0092] When preparing the isotropic concentrate composition of the present invention, the required ingredients can be mixed with conventional equipment under moderate shear and atmospheric conditions, using a temperature of 35°C to 80°C. Water is added to the isotropic concentrate composition to produce the final use composition. Moderate shearing, such as shaking (or stirring) in a container, will produce the final use composition in less than 5 minutes, preferably in less than 3 minutes, and most preferably in less than 2 minutes. In one embodiment of the present invention, the final use composition is prepared in less than 1 minute, even preferably in less than 30 seconds.

[0093] The packaging of the composition is generally not limited, as long as the isotropic concentrate composition can be hydrated and the end-use composition can be prepared when water is added. In one embodiment of the invention, the isotropic concentrate is sold in a pouch or cartridge associated with and inserted into a bottle or can. The bottle or can is a bottle or can filled with water, and allows the concentrate to be released into the bottle or can to mix with water. Typically, the bottle or can has a lid with a pump that opens the pouch or can to release the concentrate into the water to prepare the end-use composition. This concentrate unexpectedly produces an end-use composition, such as a hand sanitizer, that has the desired properties that consumers appreciate and has no precipitation or granularity. This packaging allows unlimited refilling to always reduce plastic waste in the environment. The packaging can also be equipped with a mesh accessory in its outlet hole to release the end-use composition in the form of a foam. Conventional pumps with a mesh having a hole of 35 to 140 microns before leaving the pump are commercially available from suppliers such as Albea and Rieke.

[0094] The examples are provided to facilitate the understanding of the present invention. They are not intended to limit the scope of the claims.

[0095] Embodiment 1

[0096] The compositions shown in this example listed in the table were prepared by conventional methods and thus by mixing the ingredients with moderate shear at atmospheric conditions at a temperature of about 35 to 75° C. The resulting isotropic concentrate had a pH of about 6.9 and a viscosity of about 100 cps.

[0097] surface

[0098]

[0099]

[0100] The isotropic concentrate composition was hydrated / diluted with 3 parts of water per 1 part of concentrate. The resulting end-use composition, prepared in 1 minute with stirring, was a foamable hand washing composition suitable for refillable packaging. The viscosity of the hand washing composition was about 50 cps. Surprisingly, after 48 to 72 hours at room temperature (25° C.), neither the concentrate nor the hand washing composition showed any visible or physical signs of precipitation or crystallization. In addition, the hand washing composition of the present invention was added to a conventional foam pump dispenser. The pump dispenser discharged about 100 microliters of the hand washing composition per pump through a screen of about 100 microns without signs of clogging with precipitation, thereby producing a foam hand washing composition.

[0101] Example II

[0102] In this example, an isotropic concentrate composition similar to the concentrate prepared in Example 1 was prepared, except that the fragrance and emulsifier were not included, and the balance was water. The end-use composition was also prepared by diluting the concentrate in the manner described in Example 1. The resulting concentrate and end-use composition prepared in this example showed precipitation / crystallization in less than 24 hours at room temperature (25° C.). Both are unacceptable for consumer use.

Claims

1. An end-use composition prepared by hydrating an isotropic concentrate composition, wherein the end-use composition is free of precipitate, the isotropic concentrate composition comprising: i) 0.5 to 6% by weight of acyl isethionate; ii) 0.5 to 6% by weight of acyl taurates; iii) 3.0 to 20% by weight of a zwitterionic surfactant, wherein the zwitterionic surfactant is selected from the group consisting of cocodimethylcarboxymethyl betaine, cocamidopropyl betaine, lauroamidopropyl betaine, cocamidopropyl sulfobetaine, and mixtures thereof; iv) 10.0 to 40% by weight of a humectant comprising glycerin; v) 1.0 to 7% by weight of a fragrance; vi) 1.0 to 4.5% by weight of an emulsifier having an HLB of 8 to 19, wherein the emulsifier comprises polysorbate 20; and vii) 25 to 80% by weight of water, wherein the total surfactant in the concentrate composition accounts for 12 to 35% by weight of the isotropic concentrate composition, and further wherein the weight ratio of the emulsifier to the fragrance in the concentrate composition is 1:1 to 1:3, wherein the weight ratio of the isotropic concentrate composition to the water for hydration is from 1:1 to 1:6, and The isotropic concentrate composition has a flow rate of 100 μm using a Discovery HR-2 rheometer with a sandblasting plate having a 100 μm gap and 4-15 s. -1 Shear rate and viscosity of 30 to 6,500 cps measured at 25°C, and a pH of 4.5 to 10.

2. An end-use composition prepared by hydrating an isotropic concentrate composition, wherein the end-use composition is free of precipitate, the isotropic concentrate composition comprising: i) 0.5 to 6% by weight of acyl isethionate; ii) 0.5 to 6% by weight of acyl taurates; iii) 3.0 to 20% by weight of an amphoteric surfactant, wherein the amphoteric surfactant is selected from the group consisting of sodium lauroamphoacetate, sodium cocoamphoacetate, and mixtures thereof; iv) 10.0 to 40% by weight of a humectant comprising glycerin; v) 1.0 to 7% by weight of a fragrance; vi) 1.0 to 4.5% by weight of an emulsifier having an HLB of 8 to 19, wherein the emulsifier comprises polysorbate 20; and vii) 25 to 80% by weight of water, wherein the total surfactant in the concentrate composition accounts for 12 to 35% by weight of the isotropic concentrate composition, and further wherein the weight ratio of the emulsifier to the fragrance in the concentrate composition is 1:1 to 1:3, wherein the weight ratio of the isotropic concentrate composition to the water for hydration is from 1:1 to 1:6, and The isotropic concentrate composition has a flow rate of 100 μm using a Discovery HR-2 rheometer with a sandblasting plate having a 100 μm gap and 4-15 s. -1 Shear rate and viscosity of 30 to 6,500 cps measured at 25°C, and a pH of 4.5 to 10.

3. An end-use composition according to claim 1 or 2, wherein the isotropic concentrate composition comprises from 1 to 4.5% by weight of acyl isethionate.

4. The end-use composition of claim 1 or 2, wherein the isotropic concentrate composition comprises 1 to 4.5% by weight of acyl taurate.

5. The end use composition of claim 1 wherein the isotropic concentrate composition comprises 5 to 17% by weight of a zwitterionic surfactant.

6. The end-use composition of claim 2, wherein the isotropic concentrate composition comprises 5 to 17% by weight of an amphoteric surfactant.

7. The end-use composition according to claim 1 or 2, wherein the isotropic concentrate composition comprises 20 to 30% by weight of a humectant comprising glycerol.

8. The end-use composition of claim 1 or 2, wherein the isotropic concentrate composition comprises 1.5 to 5% by weight of fragrance.

9. The end-use composition according to claim 1 or 2, wherein the isotropic concentrate composition comprises 1.2 to 4% by weight of emulsifier.

10. The end-use composition according to claim 1 or 2, wherein the HLB of the emulsifier is 10 to 18.

11. The end-use composition according to claim 1 or 2, wherein the HLB of the emulsifier is 12 to 17.

12. The end-use composition of claim 1 or 2, wherein the isotropic concentrate composition comprises 30 to 70% by weight of water.

13. The end-use composition of claim 1 or 2, wherein the isotropic concentrate composition comprises 35 to 45% by weight of water.

14. The end use composition of claim 1 or 2, wherein the total surfactant in the concentrate composition is from 15 to 30% by weight of the isotropic concentrate composition.

15. The end use composition of claim 1 or 2, wherein the total surfactant in the concentrate composition is from 20 to 28% by weight of the isotropic concentrate composition.

16. The end-use composition according to claim 1 or 2, wherein the weight ratio of the emulsifier to the fragrance in the concentrated composition is 1:1.1-1:

2.

17. The end-use composition of claim 1 or 2, wherein the weight ratio of the isotropic concentrate composition to water for hydration is from 1:1.5 to 1:

5.

18. The end-use composition of claim 1 or 2, wherein the weight ratio of the isotropic concentrate composition to water for hydration is from 1:2 to 1:

4.

19. The end-use composition of claim 1 or 2, wherein the end-use composition is a hand washing composition suitable for use in refillable packaging.

20. The end-use composition of claim 19, wherein the hand washing composition is a foamable hand washing composition.

21. The end use composition of claim 1 or 2, wherein the end use composition is a hand washing composition prepared by mixing water and the isotropic concentrate composition within one minute, whereby the end use composition is isotropic, and wherein the viscosity does not increase when water is added to the isotropic concentrate composition.

22. The end use composition of claim 1 or 2, wherein the end use composition comprises less than 6.0% by weight sulfate.

23. The end use composition of claim 1 or 2, wherein less than 3.0% by weight sulfate is present in the end use composition.

24. The end use composition of claim 1 or 2, wherein less than 1.0% by weight sulfate is present in the end use composition.

25. The end-use composition of claim 1 or 2, wherein sulfates are absent from the end-use composition.

26. The end use composition of claim 1 or 2 wherein the acyl isethionate is sodium cocoyl isethionate and the acyl taurate is sodium methyl lauroyl taurate in the isotropic concentrate composition having a flow rate of 100 % by weight using a Discovery HR-2 rheometer using a sandblasting plate with a 100 micron gap and 4-15 s -1 Shear rate and viscosity of 50 to 3,000 cps measured at 25°C.

27. The end-use composition of claim 1 or 2, wherein the end-use composition is a body wash or shampoo composition.

28. The end-use composition of claim 1 or 2, wherein the fragrance is selected from nerolidol, geraniol, terpinolene, linalool, terpinene, limonene, pinene, camphene, citronellol, citronellal, geraniol, vanillin, terpineol, thymol, eugenol, lavender oil, clary sage oil, neroli oil, rosemary oil, ginger oil, lemon oil, thyme oil, terpinyl acetate, or mixtures thereof.

29. The end-use composition of claim 1 or 2, wherein the emulsifier further comprises Tween 40, Tween 60, Tween 80, PEG-100 stearate, cocamide MEA, PEG-8 oleate, laureth-23, or a mixture thereof.

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