Cleansing composition comprising gel

Abstract

The invention belongs to the field of daily cleaning products, and specifically relates to a cleaning composition comprising gel, wherein the cleaning solution comprises a surfactant, a moisturizer, a plant extract, an antibacterial agent, and an auxiliary material; the gel is a cross-linked hydrogel, and the maximum swelling rate in water at 25°C is ≤500%, and the dry weight loss of the gel within 24 hours of the maximum swelling is ≤5% (mass); the gel accounts for 50% to 90% of the total mass of the cleaning composition comprising the gel; the gel and the cleaning solution are prepared separately, the gel swells in the cleaning solution, and the gel contacts the skin when used, which is more gentle. In addition, the gel enhances the retention time of the cleaning solution on the skin surface, and the synergistic effect of the two realizes the advantages of mildness, good biodegradability, broad-spectrum antibacterial property, and good biocompatibility, and is suitable for people with sensitive skin.

Description

Technical Field

[0001] The invention belongs to the field of daily cleaning products, and in particular relates to a cleaning composition containing a gel. Background Art

[0002] As people age, the function of their sebaceous glands gradually declines, and the chance of skin problems increases. Various skin diseases such as eczema, psoriasis, dermatitis, xerosis, etc. greatly increase skin sensitivity.

[0003] At present, commonly used skin external products include hand sanitizer, soap, moisturizer, skin care water, etc. These skin external products have various functions. By improving various components, they have the functions of antibacterial, cleansing, relieving skin allergies, etc.

[0004] However, existing external skin cleansers are not friendly to people with overly sensitive skin due to skin diseases, allergies or other reasons. For example, hand sanitizer needs to be applied to both hands after use, which can easily cause secondary skin injury. Solid cleansers such as soap need to be rubbed to make foam, which is more irritating than the former. In addition, the ingredients of various antibacterial hand sanitizers or soaps are highly irritating and are not suitable for people with sensitive skin.

[0005] Therefore, it is an urgent problem to seek a mild, highly effective antibacterial and easy-to-use cleaning composition. Summary of the invention

[0006] In order to solve the above technical problems, the present invention provides a mild and highly antibacterial cleaning composition containing gel, which adopts surfactants to increase the cleaning ability, and can effectively inhibit common bacteria by adding antibacterial agents. The key point of the present invention is that the cleaning composition containing gel is divided into gel and cleaning liquid. When used, the gel contacts the skin and is more gentle. In addition, the gel enhances the retention time of the cleaning liquid on the skin surface.

[0007] Specifically, the technical solution of the present invention is as follows:

[0008] Cleaning compositions comprising gels, including gels and cleaning solutions;

[0009] The cleaning solution includes a surfactant, a moisturizer, a plant extract, an antibacterial agent, and auxiliary materials;

[0010] The gel is a cross-linked hydrogel, the maximum swelling rate in water at 25°C is ≤500%, and the gel dry weight loss within 24 hours of the maximum swelling is ≤5% (mass);

[0011] The gel accounts for 50% to 90% of the total mass of the cleaning composition comprising the gel;

[0012] The gel and the cleaning liquid are prepared separately, and the gel swells in the cleaning liquid.

[0013] Preferably, the surfactant is any type of surfactant commonly used in detergents or medicines, which is used to reduce the surface tension of the interface to achieve the purpose of cleaning, emulsification, and stabilization of the system. Examples of the surfactant include, but are not limited to, fatty acid soaps (e.g., sodium laurate, sodium palmitate, etc.), higher alkyl sulfates (e.g., sodium lauryl sulfate, etc.), N-acyl sarcosine (e.g., sodium lauryl sarcosinate, etc.), higher fatty acid amide sulfonates (e.g., sodium lauryl methyl taurate, etc.), alkylbenzene sulfonates, higher fatty acid ester sulfates (e.g., sodium hardened coconut oil fatty acid glycerol sulfate, etc.), N-acyl glutamates, glucosamine lauramide, lauryl dimethylaminoacetic acid Betaine, alkyl betaine, amido betaine, sorbitan fatty acid esters (e.g., sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate), glycerol polyglycerol fatty acid esters (e.g., monoerucyl glyceryl, sesquioleyl glyceryl, monostearate glyceryl, monostearate glyceryl malate, etc.), PEG-fatty acid esters (e.g., PEG-distearate, distearate glycol ester, etc.), PEG-alkyl ethers, sucrose fatty acid esters, polyquaternium-7, polyvinyl alcohol, etc. One or more of these. Those skilled in the art can select the type and dosage as needed.

[0014] More preferably, the surfactant of the present invention includes at least one of glucosamine lauramide, sulfoimidazoline betaine, sodium N-lauroyl sarcosinate, and polyquaternium-7.

[0015] Typically, in the cleaning composition comprising a gel of the present invention, the surfactant accounts for 0.01-50% of the total weight of the cleaning solution.

[0016] Examples of the moisturizing agent include, but are not limited to, one or more of glycerol, trehalose, sucrose, panthenol, propylene glycol, 1,2-pentanediol, mannitol, glycereth-26, rhamnose, raffinose, erythritol, polyethylene glycol-8, polyethylene glycol-32, methyl gluceth-10, methyl gluceth-20, PEG / PPG-17 / 6 copolymer, sodium polyglutamate, xylitol, urea, hydrolyzed sclerotium gum, sodium polyglutamate, glycerol glucoside, PPG-10 methyl glucoside, budding pullulan polysaccharide, tremella polysaccharide, PPG-20 methyl glucoside, and the like.

[0017] Typically, in the cleaning composition comprising a gel of the present invention, the humectant accounts for 1% to 20% by weight of the cleaning solution.

[0018] The ingredients of the plant extracts are ingredients known in the art for nourishing the skin, including but not limited to Sophora flavescens extract, paeonol, linalool, eucalyptol, borneol, sulfur, cicada shells, Cnidium monnieri extract, Kochia scoparia extract, Polygonum multiflorum extract, Perilla frutescens extract, calamine, soapberry saponin, Portulaca oleracea extract, ammonium glycyrrhizate, terpinene-4-ol, aloe-emodin, etc.

[0019] Typically, in the cleaning composition comprising a gel of the present invention, the plant extract comprises 0.01-10% by weight of the cleaning solution.

[0020] The auxiliary materials include but are not limited to emulsifiers, thickeners, preservatives, flavors, and pH adjusters.

[0021] The emulsifier includes, but is not limited to, one or more of sorbitan olivate, stearyl polyol-21, PEG-60 hydrogenated castor oil, glyceryl stearate / PEG-100 stearate, PPG-13-decyltetradecyl alcohol polyether-24, cetearyl glucoside, polyglyceryl-10 myristate, cetearyl glucoside, polyglyceryl-10 stearate, polyglyceryl-10 dioleate, etc. Typically, in the skin external composition of the present invention, the emulsifier accounts for 0.01-5% (by weight) of the cleaning solution.

[0022] Examples of the thickener include, but are not limited to, one or more of hydroxyethyl cellulose, hydroxypropyl cellulose, carbomer, xanthan gum, gum arabic, polyethylene glycol-14M, polyethylene glycol-90M, succinoglycan, and acrylic acid (ester) / C10-30 alkyl acrylate cross-linked polymers. Those skilled in the art can select the type and amount thereof according to needs.

[0023] Examples of the preservative include, but are not limited to, one or more of methylparaben, propylparaben, phenoxyethanol, benzyl alcohol, phenylethyl alcohol, potassium sorbate, sodium benzoate, chlorphenesin, etc. and other preservative enhancers such as pentylene glycol, hexylene glycol, caprylyl glycol, p-hydroxyacetophenone, etc.

[0024] Typically, in the skin external composition of the present invention, the preservative accounts for 0.01-5% by weight of the cleansing solution.

[0025] Examples of the pH adjuster include, but are not limited to, one or more of citric acid, sodium citrate, arginine, and triethanolamine. Those skilled in the art can select the type and amount of the pH adjuster according to specific needs.

[0026] Preferably, the components of the gel are optional cross-linkable natural polysaccharides with good biocompatibility, which can be used to prepare monomers of non-toxic polymerized hydrogels (chemical cross-linking consists of covalent bonds between polymer chains), including but not limited to sodium alginate, guar gum, xanthan gum, various types of dextran, pectin, hyaluronic acid. The gel includes polyacrylamide, polyvinyl alcohol, polyacrylic acid and its derivatives (including polyacrylic acid salts, etc.), polyvinyl pyrrolidone, polyphosphazene, polyethylene oxide and its derivatives.

[0027] More preferably, the cleaning solution of the present invention comprises the following components:

[0028]

[0029]

[0030] Preferably, the components of the gel include polyacrylic acid.

[0031] Preferably, the antibacterial agent includes at least one of terpinen-4-ol, aloe-emodin and benzisothiazolinone.

[0032] In the present invention, terpinene-4-ol and aloe-emodin are plant extracts and have antibacterial effects. Therefore, when they are added as plant extracts, those skilled in the art can selectively add or not add antibacterial agents.

[0033] Preferably, the water content of the gel is 50% to 90% (by mass);

[0034] Preferably, the water content of the gel is 50% to 70% (by mass);

[0035] Preferably, the water content of the gel is 51% to 69% (mass);

[0036] Preferably, the water content of the gel is 52% to 68% (mass);

[0037] Preferably, the water content of the gel is 53% to 67% (mass);

[0038] Preferably, the water content of the gel is 54% to 66% (mass);

[0039] Preferably, the water content of the gel is 55% to 65% (mass);

[0040] Furthermore, the present invention also provides the steps for preparing the cleaning composition comprising gel, as follows:

[0041] Heat deionized water to 65-75°C in S1 mixer, add polyvinyl alcohol continuously and evenly, and stir until completely dissolved;

[0042] S2 adds at least one of glucosamine lauramide, sulfoimidazoline betaine and sodium N-lauroyl sarcosinate, and stirs at the same temperature until the system is uniform;

[0043] S3 adds polyquaternium-7 and glycerol and continues to stir until uniform;

[0044] After the S4 system is uniform, the temperature is lowered to 35-40°C, plant extracts and antibacterial agents are added, and stirred evenly to obtain a cleaning solution.

[0045] S5 cross-linking the gel matrix or polymerizing monomers in water, adjusting the gel cross-linking agent or controlling the polymer molecular weight so that the maximum swelling of the hydrogel is ≤500%, thereby obtaining a cross-linked hydrogel;

[0046] S6 drying the cross-linked hydrogel to a water content of ≤30%;

[0047] S7: The dried cross-linked hydrogel is immersed in a cleaning solution until the swelling rate reaches 110% to 200%, thereby obtaining a cleaning composition containing the gel.

[0048] In addition, a crosslinking agent may be added to control the swelling rate, and optionally a chemical crosslinking agent with good biocompatibility is also included in the components of the cleaning composition containing the gel of the present invention.

[0049] Furthermore, the present invention realizes the use of the cleansing composition comprising the gel in a skin external composition.

[0050] The beneficial effects of the present invention are:

[0051] 1. By optimizing the content of each component and scientifically proportioning, a stable, mild and effective cleaning solution is prepared, and the cleaning solution is combined with hydrogel. When used, the gel rubs against the skin surface to produce bubbles, which increases the retention time of the cleaning solution on the skin surface, making it easier for the applicable groups to accept and more suitable for people with sensitive skin;

[0052] 2. The present invention controls the molecular weight range of the hydrogel by adjusting the molecular weight of the hydrogel during crosslinking or polymerization, so that the maximum swelling of the hydrogel in water is ≤500%, preventing the hydrogel from being transformed into a sol due to excessive swelling and thus becoming unusable. In addition, the hydrogel is well crosslinked so that the weight loss of the gel body is ≤5% (within 24 hours) when the gel is soaked in the cleaning solution. In daily use, the soaking time can be adjusted according to the frequency of use, or the hydrogel can be used cyclically with a soap box that can quantitatively replenish the cleaning solution.

[0053] 3. The present invention adopts a variety of surfactants to cooperate with the porous structure of the gel, which has fast and abundant foaming, mild nature, good biodegradability and low toxicity; it has the advantages of broad-spectrum antibacterial properties, biocompatibility and good chelating ability, and adds plant extracts and antibacterial agents, which have good inhibitory effects on Escherichia coli, Staphylococcus aureus, black mold, etc. DETAILED DESCRIPTION

[0054] The present invention is described below by specific embodiments. Unless otherwise specified, the technical means used in the present invention are methods known to those skilled in the art. In addition, the embodiments should be understood as illustrative rather than limiting the scope of the present invention, and the essence and scope of the present invention are limited only by the claims. For those skilled in the art, various changes or modifications to the material composition and dosage in these embodiments, without departing from the essence and scope of the present invention, also belong to the protection scope of the present invention.

[0055] Example 1

[0056] The cleaning liquid components of the cleaning composition comprising gel are as follows:

[0057]

[0058] In addition, it also contains 0.1% (by weight) arginine, 0.1% (by weight) methylparaben, and citric acid.

[0059] The preparation method of the cleaning composition comprising gel is as follows:

[0060] Using magnetic stirring in S1 mixer, heat 750 ml of deionized water to 70°C according to the above concentration ratio, add 5 g of polyvinyl alcohol continuously and evenly, and stir until completely dissolved;

[0061] S2 adds 20g of glucosamine lauramide, 15g of sulfoimidazoline betaine, 5g of sodium N-lauroyl sarcosinate, 2g of diethanolamine, 1g of arginine, and 1g of methylparaben in proportion, and stir at room temperature until the system is uniform;

[0062] S3 added 5 g (3.9 mL) of glycerol as a moisturizer and 0.1 g of benzisothiazolinone as an antibacterial agent, and continued stirring until uniform;

[0063] After the S4 system is uniform, the temperature is lowered to 40°C, 6 g of plant extract terpinene-4-ol and 0.5 g of aloe-emodin are added, citric acid is added to adjust the pH to 6.5, and stirred for 60 minutes until it is uniform, presenting a light yellow, transparent, slightly viscous liquid with a fragrant smell, to obtain a cleaning solution.

[0064] S5 Take 10g of sodium alginate and dissolve it in 50mL of water by magnetic stirring, then add 4wt% of Ca 2+ The solution was cross-linked, and 0.1 g of sodium carboxymethyl cellulose was added to enhance the cross-linking, so that the maximum swelling rate of the hydrogel was 328% (in 25°C water), and a cross-linked hydrogel was obtained;

[0065] S6 drying the cross-linked hydrogel to a water content of 55% (by weighing method);

[0066] S7: 20 g of the dried cross-linked hydrogel was soaked in a cleaning solution for 2 hours until the swelling rate reached 200%, and the swollen gel was taken out to obtain 40.8 g of a cleaning composition containing the gel.

[0067] The calculation formula of swelling rate is:

[0068] SR=[(W t -W s ) / W s ]×100%

[0069] Where: Wt represents the total mass of the gel at time t; Ws represents the mass of the dry gel.

[0070] Example 2

[0071] The cleaning liquid components of the cleaning composition comprising gel are as follows:

[0072]

[0073]

[0074] In addition, it also contains 0.1% (by weight) arginine, 0.1% (by weight) methylparaben, and citric acid.

[0075] The preparation method of the cleaning composition comprising gel is as follows:

[0076] Using magnetic stirring in S1 mixer, heat 800 ml of deionized water to 65°C according to the above concentration ratio, continuously and evenly add 10 g of polyvinyl alcohol, and stir until completely dissolved;

[0077] S2 adds 40g of glucosamine lauramide, 32g of sulfoimidazoline betaine, 7.5g of sodium N-lauroyl sarcosinate, 6g of diethanolamine, 1g of arginine, and 1g of methylparaben in proportion, and stir to keep warm until the system is uniform;

[0078] S3 added 15 g (3.9 mL) of glycerol as a moisturizer and 0.3 g of benzisothiazolinone as an antibacterial agent, and continued stirring until uniform;

[0079] After the S4 system is uniform, the temperature is lowered to 35°C, 8g of plant extract terpinene-4-ol and 1g of aloe-rhodiola rosea are added, citric acid is added to adjust the pH to 6.5, and stirred for 60 minutes until it is uniform, presenting a white, transparent, slightly viscous liquid with a fragrant smell, to obtain a cleaning solution.

[0080] S5: 5 ml of acrylic acid was dissolved in 30 ml of water by magnetic stirring, 0.02 g of KPS initiator (0.4% of the monomer mass) was added, and polymerization was initiated by magnetic stirring at 60°C (polymerization was completed in 32 min). The maximum swelling rate of polyacrylic acid hydrogel was 438% (in 25°C water), and a cross-linked hydrogel was obtained;

[0081] S6 drying the cross-linked hydrogel to a water content of 55% (by weighing method);

[0082] S7: 20 g of the dried cross-linked hydrogel was soaked in a cleaning solution for 2 hours until the swelling rate reached 200%, and the swollen gel was taken out to obtain 40.8 g of a cleaning composition containing the gel.

[0083] In this embodiment, the swelling rate is controlled by adjusting the monomer concentration of acrylic acid. Experiments show that as the monomer concentration increases, the swelling rate generally shows an upward trend. When the monomer concentration is 100%, the swelling rate is the largest. This is because as the molecular weight of polyacrylic acid gradually increases, the molecular chain of polyacrylic acid becomes longer, the network structure increases, and the swelling rate is large.

[0084] Example 3

[0085] The preparation method and other parts of this embodiment are the same as those of embodiment 1, except for the cleaning liquid components, which are as follows:

[0086]

[0087] After the gel is prepared, it is dried to a water content of 60%, and swelled to 216% in a cleaning solution to obtain 45 g of a cleaning composition containing a gel.

[0088] Example 4

[0089] The same as Example 1, except that the cleaning liquid surfactants are 5% sodium dodecyl sulfate and 5% ammonium dodecyl sulfate.

[0090] Example 5

[0091] The same as Example 1, except that the surfactant of the cleaning solution is 5% sodium polyoxyethylene fatty acid ether sulfate and 10% sodium α-olefin sulfonate.

[0092] Comparative Example 1

[0093] This comparative example adopts antibacterial hand sanitizer commonly found in the market, and the raw materials of the antibacterial hand sanitizer are: didecyl dimethyl ammonium acetate, cocamidopropyl betaine, polyglucoside, soybean oil ethoxylate, propylene glycol, sodium carboxymethyl cellulose, citric acid, green tea essence, tender green pigment, and water.

[0094] Antibacterial and antimicrobial effect experiment

[0095] The antibacterial and antibacterial effects of Examples 1 to 5 and Comparative Example 1 were verified, and the test was conducted in accordance with QB / T2738-2012 "Evaluation Method for Antibacterial and Antibacterial Effects of Daily Chemical Products" (experimental conditions: action time 2 minutes, action concentration 1:1). The results are shown in Table 1:

[0096] Table 1 Comparison of antibacterial and antimicrobial effects

[0097] Antibacterial project Example 1 Example 2 Example 3 Example 4 Example 5 Comparative Example 1 Escherichia coli ＞99.9％ ＞99.9％ ＞99.9％ ＞99.9％ ＞99.9％ ＞85.1％ Staphylococcus aureus ＞99.9％ ＞99.9％ ＞99.9％ ＞99.9％ ＞99.9％ ＞86.3％ Black mold ＞99.9％ ＞99.9％ ＞99.9％ ＞99.9％ ＞99.9％ ＞83.3％

[0098] It can be seen from the data in Table 1 that the cleaning composition containing the gel of the present invention has good antibacterial and antimicrobial effects, and has a good inhibitory effect on Escherichia coli, Staphylococcus aureus, black mold, etc.

[0099] In summary, the cleaning composition containing gel of the present invention adopts mild and easily degradable new surfactants such as glucosamine lauramide, sulfoimidazoline betaine, sodium N-lauroyl sarcosinate, and by adding antibacterial agents terpinen-4-ol and aloe-emodin, the scientific proportion can effectively inhibit common bacteria. It has the advantages of being mild and not hurting hands, having good antibacterial effect, etc., and is a mild and efficient antibacterial cleaning composition.

[0100] Water retention rate experiment

[0101] Since the present invention is used similarly to soap in daily use, compared with simple hand sanitizer and soap, the gel is more likely to lose water and dry out, resulting in reduced use effect. Therefore, the present invention tests the water retention rate of the cleaning composition containing the gel in each embodiment.

[0102] Table 2 Comparison of water retention effects of cleaning compositions containing gel in various embodiments (25°C, air humidity 35%)

[0103]

[0104] The above data show that the present invention has good water retention. In daily use, the viscosity of the cleaning liquid will not increase and the gel will not dry up. This is mainly because the addition of the moisturizing agent of the present invention allows water loss and compensation balance.

[0105] Sensory evaluation

[0106] 20 testers were divided into 4 groups on average, and the test group samples were randomly given according to the "double-blind" test. The testers were required to wash their hands according to their daily hand washing habits (i.e., the amount of hand sanitizer, hand washing method, and flushing time were not limited), and the foaming property, decontamination ability, irritation, flushing difficulty, and refreshing feeling of hand washing were evaluated in turn. The testers scored according to their own feelings, and the scoring standard adopted a 5-point system, among which the foaming property, decontamination ability, and refreshing feeling after washing were calculated with 1 point as the worst and 5 points as the best; irritation and flushing difficulty were calculated with 1 point as the best and 5 points as the worst. Finally, the sensory effect score of each embodiment was recorded as an average value, as shown in Table 3 below.

[0107] Table 3 Sensory evaluation of hand washing / cleaning effects of cleaning compositions containing gel

[0108] Foaming Decontamination ability Irritant Flushing difficulty Cooling sensation Example 1 4.3 4.5 1.0 1.2 4.6 Example 2 4.1 4.2 1.1 1.4 4.8 Example 3 4.2 4.3 1.1 1.3 4.6 Example 4 4.0 4.0 1.0 1.2 4.7 Example 5 4.0 4.5 1.2 1.1 4.5

[0109] From the contents of Table 3 above, it can be seen that the scores of the five examples in the evaluation of the detergency are not much different. The formula composition of the examples, except for the antibacterial agent, has little effect on the antibacterial effect. The foaming ability of Examples 1, 2 and 3 is stronger than that of Examples 4 and 5, which is mainly due to the synergistic gel porous structure of the multiple surfactants in the preferred embodiment of the present invention.

Claims

1. A cleaning composition comprising a gel, characterized in that Includes gel and cleaning solution; The cleaning solution comprises: 40 g / L glucosamine lauramide, 32 g / L sulfoimidazoline betaine, 30 g / L polyquaternium-7, 7.5 g / L sodium N-lauroyl sarcosinate, 10 g / L polyvinyl alcohol, 6 g / L diethanolamine, 15 g / L glycerol, 8 g / L terpinen-4-ol, 1 g / L aloe-emodin, 800 mL / L deionized water and 0.3 g / L benzisothiazolinone; The cleaning solution components also include 0.1% (by weight) arginine and 0.1% (by weight) methylparaben; The cleaning solution component uses citric acid to adjust the pH to 6.5; The gel is a cross-linked hydrogel with a maximum swelling rate of 438% in water at 25°C; The preparation method of the cleaning composition comprising gel is as follows: S1: Heat deionized water to 65°C, add polyvinyl alcohol continuously and evenly, and stir until it is completely dissolved; S2 adds glucosamine lauramide, sulfoimidazoline betaine and sodium N-lauroyl sarcosinate, diethanolamine, arginine and methylparaben in proportion, and stirs at the same temperature until the system is uniform; S3 adds moisturizer glycerin and benzisothiazolinone, and continues to stir until uniform; S4: lower the temperature to 35°C, add plant extracts of terpinen-4-ol and aloe-emodin, add citric acid to adjust the pH to 6.5, stir evenly, and prepare a cleaning solution; S5: dissolving acrylic acid in water, adding KPS initiator and stirring to obtain a cross-linked hydrogel; S6 drying the cross-linked hydrogel to a water content of 55%; S7: soaking the dried cross-linked hydrogel in a cleaning solution until the swelling rate reaches 200%, thereby obtaining a cleaning composition containing the gel.

2. Use of the gel-containing cleansing composition according to claim 1 in preparing a skin external application product.

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