Concentration process and control system of gelatinous Chinese medicine extract

By dynamically adjusting the process parameters during the concentration of glue Chinese medicine extract, combining the initial and current temperature, viscosity and image analysis data, the product quality consistency problem caused by different characteristics of raw materials in different batches is solved, and a higher product is achieved Quality and consistency.

CN115046654BActive Publication Date: 2025-02-11HUNAN DONGJIAN PHARMA CO LTD
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Patent Information

Application Number
CN202210636161.4
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2022-06-07
Publication Date
2025-02-11
Estimated Expiration
2042-06-07

AI Technical Summary

Technical Problem

The existing PID control scheme is difficult to ensure the consistency of product quality due to different characteristics of raw materials in different batches during the concentration of glue traditional Chinese medicine extract.

Method used

By obtaining the temperature, viscosity and initial images of the drug solution to be concentrated before the concentration starts, the hue and brightness values ​​of the drug solution are obtained using image analysis technology, dynamically set the concentration process parameters based on these parameters, and the drug is obtained intermittently during the concentration process. The current temperature, viscosity and image of the liquid should be adjusted according to the color difference and viscosity difference value.

Benefits of technology

It has achieved better adaptation to changes in the characteristics of the drug liquid, avoided product quality fluctuations caused by manual subjective judgments and experience differences, and improved product quality and quality consistency.

✦ Generated by Eureka AI based on patent content.

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Abstract

The invention relates to the technical field of Chinese medicine production and processing. The invention obtains the temperature, viscosity and initial image of the liquid medicine to be concentrated before the concentration begins, obtains the hue and lightness value of the liquid medicine image by using image analysis technology, sets the concentration process parameters adapted to the liquid medicine characteristics in combination with the temperature, viscosity, hue and lightness value of the liquid medicine to be concentrated, periodically obtains the temperature, viscosity and process monitoring image of the liquid medicine during the concentration process, and adjusts the subsequent concentration process parameters according to the color difference between the process monitoring image and the initial image and the change of the liquid medicine viscosity difference. Since the invention dynamically sets the process parameters according to the liquid medicine characteristics and their changing states, the process parameter setting strategy is more reasonable and adaptive, and the concentration process parameters can be dynamically adjusted as the physical characteristics of the liquid medicine concentration process change, and can better adapt to the changes in the liquid medicine characteristics, thereby better ensuring product quality and quality consistency.
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Description

Technical Field

[0001] The invention relates to the technical field of production and processing of traditional Chinese medicines, and in particular to a gelatinous traditional Chinese medicine extract concentration process and a control system. Background Art

[0002] Donkey-hide gelatin and tortoise shell gelatin are common commercially available gelatin-type Chinese herbal products. Gelatin-type Chinese herbal products are usually prepared by boiling raw materials in water to obtain an extract, which is then concentrated and cooled to form a gelatin block. Among them, the concentration of the extract is one of the key processes that affects the quality of the gelatin block.

[0003] At present, most factories use atmospheric pressure stirring or vacuum double-effect concentration process. During the production process, production line workers need to pay close attention to the morphological changes of the extract, which requires high work experience of workers, and it is difficult to ensure product quality and consistency. In order to reduce dependence on people, some factories have automated the traditional extract concentration workshop. By introducing PID control system to strictly and accurately control the concentration process parameters, the errors caused by manual judgment and control are reduced, so as to better ensure product quality and consistency. However, due to the differences in the quality of raw materials used in gelatinous Chinese medicine products, for example, different batches of raw materials may be different in origin, storage time, etc. These differences are very likely to lead to different physical properties of the extract obtained under the same processing conditions, which in turn leads to different product quality of different batches produced by the same PID control scheme. In other words, the existing PID control scheme does not solve the problem of product consistency caused by different characteristics of raw materials in different batches. Summary of the invention

[0004] One of the purposes of the present invention is to provide a process for concentrating a gelatinous Chinese medicine extract to better ensure product quality and quality consistency.

[0005] In order to achieve the above object, the present invention adopts the following technical scheme: a process for concentrating a gelatinous Chinese medicine extract, comprising the following steps:

[0006] Before the concentration process begins:

[0007] 1. Obtain the initial temperature, initial monitoring image and initial viscosity of the liquid to be concentrated;

[0008] 2. Determine the hue and brightness value of the initial monitoring image;

[0009] 3. Setting concentration process parameters according to initial temperature, initial viscosity, hue and lightness value, wherein the concentration process parameters include concentration temperature, holding time and pressure;

[0010] During the concentration process:

[0011] 4. Intermittently obtain the current monitoring image, current temperature and viscosity of the liquid medicine;

[0012] 5. Determine the hue and brightness value of the current monitoring image, and determine the equivalent viscosity of the corresponding initial temperature according to the current temperature and viscosity of the liquid medicine;

[0013] 6. Calculate the difference between the equivalent viscosity and the initial viscosity and calculate the color difference between the current monitoring image and the initial monitoring image according to the following formula:

[0014] ΔE=[(ΔL*) 2 +(Δa*) 2 +(Δb*) 2 ] 1 / 2 ;

[0015] In the above formula, ΔE represents the color difference value, L* represents the lightness, a* and b* represent the hue, a* represents the red-green axis, positive values ​​represent red, and negative values ​​represent green; b* represents the yellow-blue axis, positive values ​​represent yellow, and negative values ​​represent blue;

[0016] 7. Reset the concentration process parameters according to the color difference and viscosity difference calculated in step 6.

[0017] In one embodiment of the present invention, when obtaining the temperature of the drug solution to be concentrated before the concentration process begins and obtaining the current temperature of the drug solution during the concentration process:

[0018] The temperatures of the surface liquid, the middle liquid and the bottom liquid are obtained respectively, and the temperature values ​​calculated according to the following formula are used as the temperature of the liquid to be concentrated and the current temperature of the liquid:

[0019] T=p1* (T a +T c )+p2*T b ;

[0020] In the above formula, T a is the surface liquid temperature, T b is the temperature of the intermediate layer liquid, T c is the bottom liquid temperature, p1 and p2 are the set weight values, p1 and p2 are both less than 1, and p1 <p2。

[0021] In one embodiment of the present invention, in step 5, the equivalent viscosity value is calculated according to the following formula:

[0022] η ’ =k*η ;

[0023] In the above formula, η ’ is the equivalent viscosity value, η is the current viscosity value, and k is the conversion coefficient corresponding to the initial temperature;

[0024] k=exp (m / T0-m / T1), T0 is the initial temperature value, T1 is the current temperature value, m is the set material property value, m>0.

[0025] Furthermore, when setting the concentration process parameters in step 3, the type of liquid medicine is first determined based on the initial temperature, initial viscosity value, hue and lightness value, and then the corresponding process parameters are selected based on the liquid medicine type.

[0026] In one embodiment of the present invention, the concentration process further includes:

[0027] The viscosity value of the surface liquid and the viscosity value of the bottom liquid are obtained intermittently, and the difference between the two is calculated. If the difference between the two is greater than the set upper limit threshold, the heating of the liquid is immediately stopped and the lower liquid is lifted to the surface and mixed with the surface liquid until the viscosity difference between the surface liquid and the bottom liquid is less than the set lower limit threshold.

[0028] Further, in step 3, the type of the liquid medicine is determined in the following manner:

[0029] First, determine the suspected type of the liquid according to the hue and lightness value of the liquid to be concentrated, and then combine the correction coefficient value n and the material characteristic value m corresponding to each suspected type into the following formula to calculate its theoretical viscosity at the initial temperature:

[0030] η ’’ =n*exp(m / T0);

[0031] In the above formula, η ’’ is the theoretical viscosity of the suspected type at the initial temperature, T0 is the initial temperature value;

[0032] The deviation between each theoretical viscosity and the actually detected initial viscosity is calculated, and the suspected type with the smallest deviation between the theoretical viscosity and the initial viscosity is regarded as the actual liquid type.

[0033] Furthermore, taking the hue difference and viscosity difference as reference indicators, the concentration process of the liquid medicine is divided into multiple stages and corresponding concentration process parameters are set for different stages of each type of liquid medicine;

[0034] In step 7, the stage of the liquid medicine concentration process is determined according to the color difference value and the viscosity difference value calculated in step 6, and the concentration process parameters corresponding to the stage are adopted.

[0035] Furthermore, the concentration process of the liquid medicine is divided into multiple stages according to the difference reference index d value, and different stages correspond to different d value ranges;

[0036] Among them, d = p3ΔE + p4Δη; ΔE is the color difference value, Δη is the viscosity difference value, p3 and p4 are the set weight values, p3 <p4;

[0037] In step 7, the color difference value and the viscosity difference value are combined into the above formula to calculate the difference reference index d value, and then the stage of the liquid medicine concentration process is determined according to the range of the calculated d value.

[0038] In addition, the present invention also relates to a control system for concentrating a gelatinous Chinese medicine extract, which includes a data processing and analysis unit, a camera unit for generating an initial monitoring image and a current monitoring image of the medicine liquid, a temperature monitoring unit for detecting the initial temperature and the current temperature of the medicine liquid, and a viscosity monitoring unit for detecting the initial viscosity and the current viscosity of the medicine liquid; the camera unit, the temperature monitoring unit and the viscosity monitoring unit are all connected to the data processing and analysis unit, and the data processing and analysis unit is used to execute steps 1-7 in the above-mentioned gelatinous Chinese medicine extract concentration process.

[0039] Furthermore, the above-mentioned gelatinous Chinese medicine extract concentration control system also includes a storage unit, which is connected to the data processing and analysis unit and stores a data set of medicinal liquid type, difference reference index value, concentration stage and concentration process parameters constructed according to a mapping relationship. The data processing and analysis unit determines the current concentration stage of the medicinal liquid according to the medicinal liquid type and the range of the calculated difference reference index d value to retrieve and adopt the concentration process parameters corresponding to the concentration stage from the storage unit.

[0040] The present invention obtains the temperature, viscosity and initial image of the drug solution to be concentrated before the concentration begins, uses image analysis technology to obtain the hue and lightness value of the drug solution image, sets the concentration process parameters that are adapted to the drug solution characteristics in combination with the temperature, viscosity, hue and lightness value of the drug solution to be concentrated, and intermittently / periodically obtains the temperature, viscosity and process monitoring image of the drug solution in a heated state during the concentration process, and adjusts the subsequent concentration process parameters according to the color difference between the process monitoring image and the initial image and the change in the viscosity difference of the drug solution. Unlike traditional PID control that focuses on executing process control (precisely controlling process reaction conditions), the present invention dynamically sets process parameters based on the characteristics of the drug solution and its changing state, and pays more attention to the rationality / adaptability of the process parameter setting strategy (the set process parameters are more adapted to the characteristics of the drug solution). Compared with traditional manual control, the process parameters used in the initial stage of concentration in the present invention are set according to the physical properties of the drug solution to be concentrated, and the concentration process parameters can be dynamically adjusted as the physical properties of the drug solution concentration process change, avoiding product quality fluctuations caused by subjective judgment and experience differences. Based on the above improvements, compared with traditional manual and PID control schemes, the concentration process provided by the present invention can better adapt to changes in the characteristics of the drug solution, thereby better ensuring product quality and quality consistency. BRIEF DESCRIPTION OF THE DRAWINGS

[0041] Figure 1 The figure is a flow chart of the concentration process of the gelatin-based Chinese medicine extract in the embodiment. DETAILED DESCRIPTION

[0042] To facilitate understanding by those skilled in the art, the present invention is further described below in conjunction with specific embodiments and drawings. It should be pointed out in advance that although the following embodiments mainly introduce the concentration operation of tortoise shell extract, those skilled in the art should understand that the concentration process and principle of other glue-based Chinese medicines (such as donkey-hide gelatin, etc.) are similar to tortoise shell glue. In actual application, only certain parameters in the process steps need to be adaptively adjusted, which can also be applied to the concentration process in this embodiment.

[0043] Figure 1 The process of concentrating the tortoise shell extract in this embodiment is shown. The concentration process is mainly divided into two parts: before the concentration starts and during the concentration process, and the main steps involved are as follows:

[0044] 1. Before the concentration process begins.

[0045] 1. Obtain the initial temperature, initial monitoring image and initial viscosity of the tortoise shell extract to be concentrated.

[0046] 2. Determine the hue and brightness values ​​of the initial monitoring image.

[0047] 3. Set the concentration process parameters according to the initial temperature, initial viscosity, hue and lightness value. In this embodiment, the aforementioned concentration process parameters include concentration temperature, insulation time and pressure.

[0048] 2. During the concentration process.

[0049] 4. Intermittently obtain the current monitoring image, current temperature and viscosity of the tortoise shell extract.

[0050] 5. Determine the hue and brightness of the current monitoring image, and determine the equivalent viscosity of the tortoise shell extract corresponding to the initial temperature (which can be understood as cooling the current tortoise shell extract to the initial temperature) according to the current temperature and viscosity.

[0051] 6. Calculate the difference between the equivalent viscosity and the initial viscosity and calculate the color difference between the current monitoring image and the initial monitoring image according to the following formula:

[0052] ΔE=[(ΔL*) 2 +(Δa*) 2 +(Δb*) 2 ] 1 / 2 ;

[0053] In the above formula, ΔE represents the color difference value, L* represents the lightness, a* and b* represent the hue, a* represents the red-green axis, a positive value represents red, and a negative value represents green; b* represents the yellow-blue axis, a positive value represents yellow, and a negative value represents blue.

[0054] 7. Reset the concentration process parameters according to the color difference and viscosity difference calculated in step 6.

[0055] During the concentration process of tortoise shell extract, changes in temperature, viscosity and color difference can reflect changes in the physical properties of the liquid medicine. Setting and dynamically adjusting the concentration process parameters according to the physical properties of the liquid medicine and changes in the physical properties of the liquid medicine is the key to the present invention. Therefore, it is necessary to further explain the acquisition / calculation process of temperature, viscosity and color difference.

[0056] It should be pointed out that in the above steps 1 and 4, one or more sensors can be used to detect / obtain the temperature data of the tortoise shell extract to be concentrated. For example, the temperature of the liquid medicine at the center of the concentration tank can be detected by a sensor, or the temperatures of the surface liquid medicine, the middle layer liquid medicine and the bottom layer liquid medicine can be respectively obtained by multiple sensors. The temperature data of the surface liquid medicine, the middle layer liquid medicine and the bottom layer liquid medicine obtained by multiple sensors can more comprehensively and accurately reflect the heating and heat distribution of the tortoise shell extract in the concentration tank. However, this will increase the complexity of the subsequent calculation model. In order to ensure the simplicity of the calculation model, the temperature values ​​of each layer of liquid medicine can be combined into the following formula and the calculated temperature value T can be used as the temperature of the liquid medicine to be concentrated and the current temperature of the liquid medicine:

[0057] T=p1* (T a +T c )+p2*T b ;

[0058] In the above formula, T a is the surface liquid temperature, T b is the temperature of the intermediate layer liquid, T cis the temperature of the bottom liquid medicine, p1 and p2 are set weight values, both p1 and p2 are less than 1, and p1 < p2. Those skilled in the art should understand that for different extraction liquids, different values of p1 and p2 can be set. For example, when concentrating the tortoise shell extraction liquid, p1 can be取值 in the range of 0.15 to 0.3, and p2 can be取值 in the range of 0.4 to 0.7. In addition, on the basis of the multi-sensor temperature measurement scheme, the viscosity value of the surface liquid medicine and the viscosity value of the bottom liquid medicine can also be intermittently obtained during the concentration process (the frequency of obtaining the viscosity values of the surface liquid medicine and the bottom liquid medicine can be higher), and the difference between the two is calculated. If the difference between the two is greater than the set upper threshold value (for the tortoise shell extraction liquid, the upper threshold value can be取值 in the range of 40 to 60 °C), since macromolecular substances in the extraction liquid of gluey traditional Chinese medicine may sink and stratify during the concentration process, resulting in a large difference in temperature between the surface liquid medicine and the bottom liquid medicine. When the difference between the two is greater than the upper threshold value, the "bottom sticking" phenomenon may occur. At this time, the heating of the liquid medicine should be immediately suspended, and the lower layer of the liquid medicine should be lifted to the surface and mixed with the surface liquid medicine until the viscosity difference between the surface liquid medicine and the bottom liquid medicine is less than the set lower threshold value (for the tortoise shell extraction liquid, the upper threshold value can be取值 in the range of 10 to 15 °C).

[0059] Since the temperature of the liquid medicine will increase significantly compared to the initial state during the concentration process, for the extraction liquid of gluey traditional Chinese medicine, its viscosity usually decreases with the increase in temperature. Therefore, the current viscosity of the liquid medicine obtained during the concentration process is not directly comparable to the initial viscosity. Therefore, in step 5, it is necessary to first calculate the equivalent viscosity value of the current liquid medicine, and then subtract the equivalent viscosity from the initial viscosity to obtain the viscosity difference. The formula for calculating the equivalent viscosity value is as follows:

[0060] η ’ =k*η ;

[0061] In the above formula, η ’ is the equivalent viscosity value, η is the current viscosity value, and k is the conversion coefficient corresponding to the initial temperature;

[0062] k = exp(m / T0 - m / T1), T0 is the initial temperature value, T1 is the current temperature value, m is the set material characteristic value, m > 0 (for the tortoise shell extraction liquid, m can be取值 between 7264 and 8350).

[0063] The method of obtaining the hue and lightness values ​​of the image in the above steps 2 and 5 belongs to the prior art and will not be described in detail here. As for calculating the color difference between the current monitoring image and the initial monitoring image in step 7, it is also relatively simple. It can be seen from the color difference calculation formula in step 7 that before calculating the color difference value, it is only necessary to first calculate the hue difference Δa*, Δb* and lightness difference ΔL* between the current monitoring image and the initial monitoring image, and then perform square root processing on the sum of the squares of the hue difference value and the lightness difference value to obtain the color difference value.

[0064] It should be noted that when setting the concentration process parameters in the aforementioned step 3, the technicians in this field can directly set the concentration process parameters according to the initial temperature, initial viscosity, hue and brightness of the liquid medicine. For example, a table can be constructed according to the mapping relationship between the initial temperature range, initial viscosity range, hue and brightness value range and the concentration process parameters, and then the initial temperature, initial viscosity, hue and brightness of the liquid medicine to be concentrated are matched with the initial temperature range, initial viscosity range, hue and brightness value range in the table ("lookup table" method), and finally the matching concentration process parameters are selected and applied. It is also possible to first determine the liquid medicine type according to the initial temperature, initial viscosity value, hue and brightness value, and then select the corresponding process parameters according to the liquid medicine type. For example, the type of liquid medicine can be determined in the following way: first determine the suspected type of the liquid medicine according to the hue and lightness value of the liquid medicine to be concentrated, and then combine the correction coefficient value n and the material characteristic value m corresponding to each suspected type (a table can be constructed in advance according to the mapping relationship between the liquid medicine type and the correction coefficient value n and the material characteristic value m, in which the corresponding correction coefficient value and material characteristic value are respectively configured for each liquid medicine type, and then the correction coefficient value and material characteristic value corresponding to the suspected type can be obtained by "looking up the table". It should be pointed out that the correction coefficient value and material characteristic value of different liquid medicine types can be different. Of course, the same correction coefficient value and material characteristic value can be configured for certain different liquid medicine types according to the situation) to the following formula to calculate its theoretical viscosity at the initial temperature:

[0065] η ’’ =n*exp(m / T0);

[0066] In the above formula, η ’’ is the theoretical viscosity of the suspected type at the initial temperature, and T0 is the initial temperature value.

[0067] Afterwards, the deviation values ​​between the theoretical viscosities and the actually detected initial viscosities are calculated, and the suspected type with the smallest deviation value between the theoretical viscosity and the initial viscosity is regarded as the actual type of drug solution, and then the concentration process parameters suitable for the drug solution type are set. Of course, a "drug solution type-concentration process parameter table" can be constructed in advance according to the mapping relationship between the drug solution type and the concentration process parameters, and the concentration process parameters corresponding to the drug solution type can be obtained and applied by "looking up the table".

[0068] On this basis, the chromatic aberration value and viscosity difference value can also be used as reference indicators to divide the concentration process of the liquid medicine into multiple stages and set corresponding concentration process parameters for different stages of each type of liquid medicine. For example, the concentration process of the liquid medicine can be divided into multiple stages according to the difference reference indicator d value, and different concentration stages correspond to different d value ranges; where d = p3ΔE + p4Δη; ΔE is the chromatic aberration value, Δη is the viscosity difference value, p3 and p4 are set weight values, and p3 < p4. Since the type of the liquid medicine has been determined based on the initial temperature, initial viscosity value, hue and lightness value before the concentration starts, in step 7, the chromatic aberration value and viscosity difference value calculated in step 6 can be combined with the above formula to calculate the difference reference indicator d value, and then the stage of the liquid medicine concentration process can be determined according to the range where the calculated d value is located, and then the concentration process parameters suitable / corresponding to the current concentration stage of the liquid medicine can be selected and applied.

[0069] Those skilled in the art should understand that in actual production applications, the above-mentioned concentration process (including the steps before the concentration starts) can be controlled and implemented by a concentrated control system for traditional Chinese medicine extract of glue type. The concentrated control system for traditional Chinese medicine extract of glue type should include a data processing and analysis unit, a camera unit for generating the initial monitoring image and the current monitoring image of the liquid medicine, a temperature monitoring unit for detecting the initial temperature and the current temperature of the liquid medicine, and a viscosity monitoring unit for detecting the initial viscosity and the current viscosity of the liquid medicine; the camera unit, the temperature monitoring unit and the viscosity monitoring unit are all connected to the data processing and analysis unit, and the data processing and analysis unit obtains corresponding data from the camera unit, the temperature monitoring unit and the viscosity monitoring unit and executes steps 1-7 in the above-mentioned concentrated process of traditional Chinese medicine extract of glue type. In addition, the concentrated control system for traditional Chinese medicine extract of glue type can also include a storage unit connected to the data processing and analysis unit. The storage unit should store a data set of liquid medicine types, difference reference indicator values, concentration stages and concentration process parameters constructed according to the mapping relationship (this data set can be a table containing the mapping relationship of liquid medicine types, difference reference indicator values, concentration stages and concentration process parameters). The aforementioned data processing and analysis unit determines the current concentration stage of the liquid medicine according to the liquid medicine type and the range where the calculated difference reference indicator d value is located, so as to retrieve and adopt the concentration process parameters corresponding to this concentration stage from the storage unit.

[0070] Unlike traditional PID control which focuses on process control (precisely controlling process reaction conditions), this embodiment obtains the temperature, viscosity and initial image of the drug solution to be concentrated before the concentration begins, uses image analysis technology to obtain the hue and brightness value of the drug solution image, and sets the concentration process parameters that are suitable for the drug solution characteristics in combination with the temperature, viscosity, hue and brightness value of the drug solution to be concentrated. In the concentration process, the temperature, viscosity and process monitoring image of the drug solution in the heated state are intermittently / periodically obtained, and the subsequent concentration process parameters are adjusted according to the color difference between the process monitoring image and the initial image and the change in the viscosity difference of the drug solution. Since this embodiment dynamically sets the process parameters according to the characteristics of the drug solution and its changing state, it pays more attention to the rationality / adaptability of the process parameter setting strategy (the set process parameters are more suitable for the characteristics of the drug solution). Compared with traditional manual control, the process parameters used in the initial stage of concentration in this embodiment are set according to the physical properties of the drug solution to be concentrated, and the concentration process parameters can be dynamically adjusted as the physical properties of the drug solution concentration process change, avoiding product quality fluctuations caused by subjective judgment and experience differences. Through the above improvements, compared with the traditional manual and PID control schemes, the concentration process adopted in this embodiment can better adapt to the changes in the characteristics of the drug solution, thereby better ensuring product quality and quality consistency.

[0071] The above embodiments are preferred implementation schemes of the present invention. In addition, the present invention may also be implemented in other ways. Any obvious replacement without departing from the concept of the present technical solution is within the protection scope of the present invention.

[0072] In order to make it easier for ordinary technicians in the field to understand the improvements of the present invention over the prior art, some drawings and descriptions of the present invention have been simplified, and for the sake of clarity, some other elements are omitted in this application document. Ordinary technicians in the field should realize that these omitted elements may also constitute the content of the present invention.

Claims

1. A process for concentrating a gelatinous Chinese medicine extract, characterized in that: Before the concentration process begins: Step 1. Obtaining the initial temperature, initial monitoring image and initial viscosity of the drug solution to be concentrated; Step 2. Determine the hue and brightness value of the initial monitoring image; Step 3. Setting concentration process parameters according to initial temperature, initial viscosity, hue and lightness value, wherein the concentration process parameters include concentration temperature, holding time and pressure; During the concentration process: Step 4. intermittently obtain the current monitoring image, current temperature and viscosity of the drug solution; Step 5. Determine the hue and brightness value of the current monitoring image, and determine the equivalent viscosity of the corresponding initial temperature according to the current temperature and viscosity of the liquid medicine; Calculate the equivalent viscosity value according to the following formula: or ’ =k*η; In the above formula, η ’ is the equivalent viscosity value, η is the current viscosity value, k is the conversion coefficient corresponding to the initial temperature, k=exp (m / T0-m / T1), T0 is the initial temperature value, T1 is the current temperature value, m is the set material characteristic value, m>0; Step 6. Calculate the difference between the equivalent viscosity and the initial viscosity and calculate the color difference between the current monitoring image and the initial monitoring image according to the following formula: ΔE=[(ΔL*) 2 +(Δa*) 2 +(Δb*) 2 ] 1 / 2 ; In the above formula, ΔE represents the color difference value, L* represents the lightness, a* and b* represent the hue, a* represents the red-green axis, positive values ​​represent red, and negative values ​​represent green; b* represents the yellow-blue axis, positive values ​​represent yellow, and negative values ​​represent blue; Step 7. Reset the concentration process parameters according to the color difference and viscosity difference calculated in step 6.

2. The process for concentrating the gelatinous Chinese medicine extract according to claim 1, characterized in that: When obtaining the temperature of the liquid to be concentrated before the concentration process begins and obtaining the current temperature of the liquid during the concentration process: The temperatures of the surface liquid, the middle liquid and the bottom liquid are obtained respectively, and the temperature values ​​calculated according to the following formula are used as the temperature of the liquid to be concentrated and the current temperature of the liquid: T=p1* (T a +T c )+p2*T b ; In the above formula, T a is the surface liquid temperature, T b is the temperature of the intermediate layer liquid, T c is the bottom liquid temperature, p1 and p2 are the set weight values, p1 and p2 are both less than 1, and p1 <p 2。 3. The process for concentrating the gelatinous Chinese medicine extract according to claim 2, characterized in that: When setting the concentration process parameters in step 3, first determine the type of liquid medicine according to the initial temperature, initial viscosity value, hue and lightness value, and then select the corresponding process parameters according to the liquid medicine type.

4. The process for concentrating the gelatinous Chinese medicine extract according to claim 2, characterized in that: The concentration process also includes: The viscosity value of the surface liquid and the viscosity value of the bottom liquid are obtained intermittently, and the difference between the two is calculated. If the difference between the two is greater than the set upper limit threshold, the heating of the liquid is immediately stopped and the lower liquid is lifted to the surface and mixed with the surface liquid until the viscosity difference between the surface liquid and the bottom liquid is less than the set lower limit threshold.

5. The process for concentrating the gelatinous Chinese medicine extract according to claim 3, characterized in that: In step 3, determine the type of liquid medicine as follows: First, determine the suspected type of the liquid according to the hue and lightness value of the liquid to be concentrated, and then combine the correction coefficient value n and the material characteristic value m corresponding to each suspected type into the following formula to calculate its theoretical viscosity at the initial temperature: η ’ ’ =n*exp(m / T0) ; In the above formula, η ’ ’ is the theoretical viscosity of the suspected type at the initial temperature, T0 is the initial temperature value; The deviation between each theoretical viscosity and the actually detected initial viscosity is calculated, and the suspected type with the smallest deviation between the theoretical viscosity and the initial viscosity is regarded as the actual liquid type.

6. The process for concentrating the gelatinous Chinese medicine extract according to claim 5, characterized in that: Taking the hue difference and viscosity difference as reference indicators, the concentration process of the liquid medicine is divided into multiple stages and corresponding concentration process parameters are set for different stages of each type of liquid medicine; In step 7, the stage of the liquid medicine concentration process is determined according to the color difference value and the viscosity difference value calculated in step 6, and the concentration process parameters corresponding to the stage are adopted.

7. The process for concentrating the gelatinous Chinese medicine extract according to claim 6, characterized in that: The concentration process of the drug solution is divided into multiple stages according to the difference reference index d value, and different stages correspond to different d value ranges; Among them, d = p3ΔE + p4Δη; ΔE is the color difference value, Δη is the viscosity difference value, p3 and p4 are the set weight values, p3 <p4; In step 7, the color difference value and the viscosity difference value are combined into the above formula to calculate the difference reference index d value, and then the stage of the liquid medicine concentration process is determined according to the range of the calculated d value.

8. The control system for the concentration of gelatinous Chinese medicine extracts is characterized by: It includes a data processing and analysis unit, a camera unit for generating an initial monitoring image and a current monitoring image of the medicinal liquid, a temperature monitoring unit for detecting the initial temperature and the current temperature of the medicinal liquid, and a viscosity monitoring unit for detecting the initial viscosity and the current viscosity of the medicinal liquid; the camera unit, the temperature monitoring unit and the viscosity monitoring unit are all connected to the data processing and analysis unit, and the data processing and analysis unit is used to execute steps 1-7 in the gelatinous Chinese medicine extract concentration process described in claim 7.

9. The control system for concentrating the gelatinous Chinese medicine extract according to claim 8, characterized in that: It also includes a storage unit, which is connected to the data processing and analysis unit and stores a data set of liquid medicine type, difference reference index value, concentration stage and concentration process parameters constructed according to a mapping relationship. The data processing and analysis unit determines the current concentration stage of the liquid medicine according to the liquid medicine type and the range of the calculated difference reference index d value to retrieve and adopt the concentration process parameters corresponding to the concentration stage from the storage unit.

Citation Information

Patent Citations

  • Intelligent automated control method for traditional Chinese medicine production

    CN102109846A

  • Production control method for Chinese medicine extraction tank

    CN102566524A