Intranasal wearable dynamic respiratory flow intelligent monitoring and drug delivery system

Abstract

The present application relates to a kind of intranasal wearable dynamic respiratory flow intelligent monitoring and dosing system, comprising: intranasal flexible support frame, it is configured to carry gas flow sensor, and can be fixed in nasal cavity inside;Gas flow sensor, it is configured to detect breathing signal and transmit to integrated circuit module;Integrated circuit module, it is configured to power supply the gas flow sensor, and receive the breathing signal of the gas flow sensor collection process and storage, and can drive micro pump dosing module operation;And micro pump dosing module, it is configured to deliver drug to nasal cavity inside.

Description

Technical Field

[0001] This invention relates to the field of respiratory monitoring technology, and in particular to an intranasal wearable intelligent monitoring and drug delivery system for dynamic respiratory flow. Background Technology

[0002] Currently, China has a large population and severe environmental pollution, leading to a year-on-year increase in the number of people suffering from chronic respiratory diseases. Regular pulmonary function tests play a positive role in the diagnosis and treatment of these diseases. Hospitals commonly use pulmonary function testing equipment to examine and assess patients' ventilation, gas exchange, and respiratory physiological status. This allows for early detection of small airway diseases and is of high value in diagnosing and guiding the treatment of lung diseases such as bronchitis, bronchial asthma, pneumonia, pulmonary fibrosis, and bronchiectasis. While pulmonary function testing equipment with calculation, storage, and interactive functions is available on the market, it is expensive, has low measurement accuracy, is cumbersome to operate, and is not portable, making it unsuitable for home monitoring and the need for precise monitoring and treatment anytime, anywhere. Summary of the Invention

[0003] The objective of this invention is to provide an intranasal wearable intelligent monitoring and drug delivery system for dynamic respiratory flow, which enables real-time respiratory monitoring and intranasal drug delivery. It can be worn for extended periods, is easy to operate, low in cost, has high measurement accuracy, and is not limited by monitoring location.

[0004] To address the problems existing in the prior art, the present invention provides an intranasal wearable intelligent monitoring and drug delivery system for dynamic respiratory flow, comprising:

[0005] A flexible nasal support frame, which is configured to carry a gas flow sensor and can be fixed inside the nasal cavity;

[0006] A gas flow sensor is configured to detect respiratory signals and transmit them to an integrated circuit module;

[0007] An integrated circuit module configured to power the gas flow sensor, receive, process, and store respiratory signals collected by the gas flow sensor, and drive the micropump drug delivery module; and

[0008] A micropump drug delivery module is configured to deliver drugs into the nasal cavity.

[0009] In one embodiment of the present invention, customized software is also included, which is configured to control the operation of the intranasal wearable dynamic respiratory flow intelligent monitoring and drug delivery system, receive the respiratory signal processed by the integrated circuit module, perform calculations, and display the results, wherein the customized software is loaded on the operating medium.

[0010] In one embodiment of the invention, the intranasal flexible support frame includes two supports and a connector connecting the two supports.

[0011] In one embodiment of the present invention, the connector includes a connecting platform and connecting sidewalls located on both sides of the connecting platform; and

[0012] The fixing bracket is located on the connecting side wall of the connector, and the ring of the fixing bracket is located in the middle of the end face of the support.

[0013] In one embodiment of the present invention, the gas flow sensor is fitted into the ring of the fixed bracket and fixed at the center position of the support.

[0014] In one embodiment of the present invention, the gas flow sensor includes a flexible ultrafine tube, a metal spiral coil located on the surface of the flexible ultrafine tube, and an insulating layer covering the metal spiral coil. Forming the metal spiral coil includes: distributing photoresist on the surface of the flexible ultrafine tube, then photolithographically etching a spiral circuit pattern, and electroplating or depositing metal in the circuit pattern to form the metal spiral coil; and...

[0015] The metal spiral coil is connected to the integrated circuit module via leads.

[0016] In one embodiment of the present invention, the micropump drug delivery module includes a microtube and a micropump, wherein the microtube is connected to the flexible ultrafine tube;

[0017] The micropump includes:

[0018] Medicine chamber, used to store medicines;

[0019] The drug delivery tubing is equipped with a valve between itself and the drug chamber, and is connected to the flexible ultrafine tube; and

[0020] The micropump is connected to the integrated circuit module via a signal or lead.

[0021] In one embodiment of the present invention, the integrated circuit module is mounted on the connector, and the integrated circuit module includes:

[0022] A respiratory signal acquisition module acquires the respiratory signals detected by the gas flow sensor;

[0023] Low-frequency filter, which filters the breathing signal and removes interference signals;

[0024] An operational amplifier amplifies the filtered respiratory signal;

[0025] The microcontroller powers the gas flow sensor and stores respiratory signals, and has a control unit that can determine whether there is abnormal breathing or a certain respiratory disease based on the calculation results of the customized software, and can drive the micropump of the micropump drug delivery module to operate.

[0026] In one embodiment of the present invention, the intranasal flexible support frame is selected according to the gender, height and weight of the test subject, and the size of the intranasal flexible support frame is selected in the operation interface of the customized software to determine the method for calculating respiratory flow.

[0027] The intranasal flexible support frame is placed inside the nasal cavity;

[0028] The integrated circuit module is activated through the user interface of the customized software to power the gas flow sensor. The gas flow sensor detects the breathing signal, and the integrated circuit module collects, filters, amplifies, and stores the breathing signal.

[0029] The respiratory signal processed by the integrated circuit module is transmitted to the customized software;

[0030] The customized intelligent software analyzes and calculates the respiratory signals, generates a respiratory gas flow signal curve, and displays it on the screen of the operating medium. Simultaneously, it transmits the calculation results to the control unit of the integrated circuit module.

[0031] The control unit determines whether there is abnormal breathing or a certain respiratory disease. If there is abnormal breathing or a certain respiratory disease, the control unit drives the micropump to operate, opens the valve, and delivers the drug in the drug chamber to the inside of the nasal cavity through the drug delivery tubing, the microtube, and the flexible ultrafine tube.

[0032] In one embodiment of the present invention, the support is elliptical, with a major axis of 8mm-11mm and a minor axis of 5mm-8mm at its end face; and / or

[0033] The wall thickness of the support and the connector is 1mm-2mm; and / or

[0034] The connector is 6mm-9mm long.

[0035] In one embodiment of the present invention, the flexible ultrafine tube has a length of 6mm-10mm and a diameter of 0.3mm-1mm; and / or

[0036] The flexible ultrafine tube is a hollow tube, wherein when the flexible ultrafine tube is a hollow tube, the tube wall thickness is 0.025mm-0.25mm; and / or

[0037] The metal spiral coils wound on the flexible ultrafine tube are spaced 100µm-300µm apart and have 5-20 turns; and / or

[0038] The linewidth of the metal spiral coil is 10um-200um.

[0039] The present invention has at least the following beneficial effects: The intranasal wearable dynamic respiratory flow intelligent monitoring and drug delivery system disclosed herein enables real-time respiratory monitoring and intranasal drug delivery treatment. It can be worn for extended periods, greatly expanding the amount of respiratory data collected, which is of great significance for the analysis and diagnosis of respiratory diseases. The intranasal wearable dynamic respiratory flow intelligent monitoring and drug delivery system is characterized by convenient operation, low cost, high measurement accuracy, no location restrictions, and real-time result viewing, making it suitable for home use and beneficial for the early screening and treatment of respiratory diseases, thus possessing significant potential for widespread application. This monitoring system can independently and in real-time measure the flow in both nasal cavities. The nasal flow rate data directly reflects changes in tidal volume or the nasal cycle, enabling personalized health assessments and customized treatment plans. The gas flow sensor, fabricated on a flexible ultra-fine tube, can be inserted into the nasal cavity for measurement and is less susceptible to environmental airflow factors, resulting in extremely high signal measurement accuracy. The intranasal wearing method avoids interference from external environmental factors during monitoring, making the results more accurate and reliable. Diverse flexible intranasal support designs can adapt to the needs of different individuals and simultaneously correct the nasal flow rate calculation method, leading to more precise measurement results. Attached Figure Description

[0040] To further illustrate the above and other advantages and features of the various embodiments of the present invention, a more specific description of the embodiments of the invention will be presented with reference to the accompanying drawings. It is to be understood that these drawings depict only typical embodiments of the invention and are therefore not intended to limit its scope. In the drawings, identical or corresponding parts will be indicated by identical or similar reference numerals for clarity.

[0041] Figure 1 A perspective view of an intranasal wearable dynamic respiratory flow intelligent monitoring and drug delivery system according to an embodiment of the present invention is shown.

[0042] Figure 2 A front view of an intranasal flexible support frame equipped with a gas flow sensor according to an embodiment of the present invention is shown.

[0043] Figure 3 A top view of an intranasal flexible support frame equipped with a gas flow sensor according to an embodiment of the present invention is shown.

[0044] Figure 4A schematic diagram of a gas flow sensor according to an embodiment of the present invention is shown;

[0045] Figure 5 A flowchart of a nasal wearable dynamic respiratory flow intelligent monitoring and drug delivery system according to an embodiment of the present invention is shown; and

[0046] Figure 6 A before-and-after comparison diagram of a wearable intelligent respiratory flow monitoring and drug delivery system according to an embodiment of the present invention is shown. Detailed Implementation

[0047] It should be noted that the components in the accompanying drawings may be shown exaggerated for illustrative purposes and may not be to scale.

[0048] In this invention, the various embodiments are merely intended to illustrate the solutions of the invention and should not be construed as limiting.

[0049] In this invention, unless otherwise specified, the quantifiers “a” and “one” do not exclude scenarios involving multiple elements.

[0050] It should also be noted that, in the embodiments of the present invention, only a portion of the parts or components may be shown for clarity and simplicity. However, those skilled in the art will understand that, under the teachings of the present invention, the required parts or components can be added as needed for specific scenarios.

[0051] It should also be noted that within the scope of this invention, the terms "same", "equal", and "equal to" do not mean that the two values ​​are absolutely equal, but allow for a certain reasonable error. In other words, the terms also cover "substantially the same", "substantially equal", and "substantially equal to".

[0052] It should also be noted that in the description of this invention, the terms "center," "longitudinal," "lateral," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are used only for the convenience of describing the invention and for simplifying the description, and do not explicitly or implicitly suggest that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on the invention. Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0053] Furthermore, the embodiments of the present invention describe the process steps in a specific order. However, this is only for the convenience of distinguishing each step, and is not a limitation on the order of each step. In different embodiments of the present invention, the order of each step can be adjusted according to the process.

[0054] Figure 1 A perspective view of an intranasal wearable dynamic respiratory flow intelligent monitoring and drug delivery system according to an embodiment of the present invention is shown. Figure 2 A front view of an intranasal flexible support frame equipped with a gas flow sensor according to an embodiment of the present invention is shown. Figure 3 A top view of an intranasal flexible support frame equipped with a gas flow sensor according to an embodiment of the present invention is shown. Figure 4 A schematic diagram of a gas flow sensor according to an embodiment of the present invention is shown.

[0055] like Figures 1 to 4 As shown, the intranasal wearable dynamic respiratory flow intelligent monitoring and drug delivery system includes an intranasal flexible support frame 1, a gas flow sensor 2, and a micropump drug delivery module. The main material of the intranasal flexible support frame 1 is colorless and transparent silicone. The intranasal flexible support frame 1 includes two supports 11 and one connector 12, with a wall thickness of 1mm-2mm for both supports 11 and connector 12. Preferably, the supports 11 are elliptical in shape, which allows them to be well fixed inside the nasal cavity. The major axis of the end face of the support 11 is 8mm-11mm, and the minor axis is 5mm-8mm.

[0056] Connector 12 is used to connect two supports 11. Connector 12 is 6mm-9mm long and its surface can be equipped with an integrated circuit module. Connector 12 has a connecting platform 121 and connecting sidewalls 122 located on both sides of the connecting platform 121. The two connecting sidewalls 122 are respectively connected to the supports 11. The connecting platform 121 of connector 12 is equipped with an integrated circuit module. The material of connector 12 can be the same as or different from the material of the intranasal flexible support frame 1.

[0057] Two fixed brackets 13 are respectively located on the two connecting side walls 122 of the connector 12, and the ring 131 of the fixed bracket 13 is located in the middle of the end face of the support 11.

[0058] Those skilled in the art should understand that the materials, shapes, and sizes of intranasal flexible support frames are not limited to the examples above, and they can choose the materials, shapes, and sizes of intranasal flexible support frames according to actual needs.

[0059] A gas flow sensor 2, used to detect respiratory signals and transmit them to an integrated circuit module, comprises a flexible ultrafine tube 21 and a metal spiral coil 22, with an outermost insulating layer. The flexible ultrafine tube 21 can be made of polyimide, PMPM material, or quartz. These materials offer advantages such as high flexibility, high elasticity, corrosion resistance, and good biocompatibility. The flexible ultrafine tube 21 is 6mm-10mm long and 0.3mm-1mm in diameter, and is a hollow tube. The wall thickness of the flexible ultrafine tube is 0.025mm-0.25mm. The metal spiral coil 22 is the sensor's sensitive element, primarily made of gold, but other sensitive materials can also be used. The linewidth of the metal spiral coil 22 is 10um-200um. The metal spiral coil 22 is located on the surface of the flexible ultrafine tube 21, with a spacing of 100um-300um and 5-20 turns. The outermost layer of the gas flow sensor 2 is an insulating layer made of insulating material, such as Parylene insulating material. The thickness of the insulating layer is 10um-50um, which ensures the surface electrical insulation of the gas flow sensor 2, isolates water vapor in the environment, and improves the durability of the gas flow sensor 2.

[0060] The gas flow sensor 2 can be fitted into the ring 131 of the fixed bracket 13, and the gas flow sensor 2 is fixed at the center position of the support 11 (e.g., Figure 2 (As shown). The metal spiral coil 22 of the gas flow sensor 2 can be connected to the integrated circuit module via leads. The integrated circuit module can be fixed to the connector 12. The integrated circuit module powers the gas flow sensor 2 and collects, processes, and stores respiratory signals, which are then transmitted wirelessly to a mobile phone or other operating medium with customized software via Bluetooth. Alternatively, the respiratory signals can be stored on a TF memory card, and after monitoring is complete, a reader can be used to import the collected signals into customized software for analysis.

[0061] The micropump drug delivery module includes a microtube 31 and a micropump 32. The micropump 32 can be a piezoelectric pump, electrostatic pump, magnetic pump, pneumatic pump, or other micropumps. The micropump 32 contains a drug chamber 321 and a drug delivery line 322. A valve 323 is installed between the drug chamber 321 and the drug delivery line 322. The drug chamber 321 is connected to one end of the drug delivery line 322, and the valve 323 is used to close and open the drug delivery line 322. The other end of the drug delivery line 322 is connected to one end of the microtube 31. The other end of the microtube 31 is connected to a flexible ultrafine tube 21. An integrated circuit module can control the micropump drug delivery module to deliver the drug through the flexible ultrafine tube 21 into the human nasal cavity. The integrated circuit module is connected to the micropump 32 via a signal or circuit connection. The control unit in the integrated circuit module can drive the micropump 32 to operate, open the valve 323, pump the drug in the drug chamber 321 into the drug delivery line 322, then deliver it to the microtube 31, and finally deliver it to the inside of the human nasal cavity through the flexible ultra-fine tube 21.

[0062] Those skilled in the art should understand that the material, size, and spacing of the metal spiral coil are not limited to the specific examples described above. They can select the material and size of the flexible ultrafine tube according to actual needs. Leads are connected to both ends of the metal spiral coil. The width of the leads can be the same as that of the metal spiral coil, or its width can be increased as needed, to achieve electrical conduction between the metal spiral coil and the integrated circuit module. Commercially available conductors, enameled wire, or copper wire can be used as leads.

[0063] Those skilled in the art should understand that the material and thickness of the insulating layer are not limited to the examples above, and they can choose the material and thickness of the insulating layer according to actual needs.

[0064] Different sizes of intranasal flexible support frames can be selected according to the wearer's gender and height. The design of the intranasal flexible support frame is ergonomic and has been adjusted according to the structure of the human nasal cavity. While ensuring flexibility, it has high support strength and can be directly inserted into the nasal cavity to support the nasal cartilage, keep the airflow unobstructed, and fix the cross-sectional area of ​​the airflow.

[0065] The integrated circuit module includes a respiratory signal acquisition module, a low-frequency filter, an operational amplifier, and a microcontroller (STM32 system version).

[0066] The respiratory signal acquisition module acquires the respiratory signal detected by the gas flow sensor 2, filters the signal using a low-frequency filter to remove interference signals, amplifies the filtered signal using an operational amplifier, and stores it in the microcontroller. The microcontroller can also power the gas flow sensor.

[0067] The intranasal wearable dynamic respiratory flow intelligent monitoring and drug delivery system also includes customized software. This customized software controls the operation of the intranasal wearable dynamic respiratory flow intelligent monitoring and drug delivery system, receives respiratory signals processed by the integrated circuit module, performs calculations, and displays the results. The customized software is installed on operating media such as mobile phones, tablets, and laptops.

[0068] The microcontroller of the integrated circuit module also includes a control unit. Customized software transmits the calculation results to the control unit. The control unit determines whether there is an abnormal breathing or a certain respiratory disease based on the calculation results of the customized software. If so, the control unit automatically drives the micropump of the micropump drug delivery module to run, and delivers the drug to the nasal cavity for treatment through the flexible ultra-fine tube of the gas flow sensor.

[0069] The manufacturing method of a gas flow sensor is as follows:

[0070] Photoresist is applied to the surface of a flexible ultrafine tube through coating, deposition, and lamination. A spiral circuit pattern is then photolithographically created using exposure and development processes. Metal is electroplated or deposited within the circuit pattern to form a metal spiral coil. Finally, the photoresist is removed. The metal spiral coil formed in this manner is a thin film, enabling more sensitive detection of respiratory signals.

[0071] The working principle of the gas flow sensor is introduced below.

[0072] The gas flow sensor's measurement principle is based on the thermal resistance effect. After assembling the metal spiral coil, leads, and integrated circuit module, a direct current (DC) of 3-5 mA is applied to the metal spiral coil through the leads. When energized, the metal spiral coil generates Joule heat, causing a localized increase in temperature on its surface and within the flexible ultrafine tube. This increases the coil's resistance and consequently, the voltage across its terminals. When respiratory airflow passes through the surface and interior of the flexible ultrafine tube, heat exchange occurs between the airflow and the metal spiral coil, lowering its surface temperature, reducing its resistance, and decreasing the voltage across its terminals. Since the velocity and temperature of exhaled and inhaled airflow differ, the actual breathing status can be reflected by measuring the voltage across the metal spiral coil, thus achieving the effect of monitoring human respiration.

[0073] Mobile phones or other portable operating media can be loaded with customized software compatible with the intranasal wearable dynamic respiratory flow intelligent monitoring and drug delivery system. Users can view the collected respiratory data in real time on the screen and transmit the data to an integrated circuit module. The control unit of the integrated circuit module determines whether intranasal drug delivery is needed and can then perform intranasal drug delivery. The customized software can calculate the actual cross-sectional area of ​​the gas passage based on the dimensions of the flexible support frame used, and, combined with the measured gas velocity, calculate the corresponding actual respiratory flow in each of the two nasal cavities. The customized software can continuously record respiratory flow data in both nasal cavities for 24-48 hours or more. This data can be used for early screening and diagnosis of various respiratory diseases, for analyzing changes in the human nasal cycle and respiratory signals, and can also be connected to a human health intelligent monitoring network to comprehensively assess human health status by combining various human physiological signals (such as blood pressure, blood sugar, heart rate, etc.).

[0074] Figure 5 A flowchart of a nasal wearable dynamic respiratory flow intelligent monitoring and drug delivery system according to an embodiment of the present invention is shown. Figure 6 A before-and-after comparison diagram of a wearable intelligent respiratory flow monitoring and drug delivery system according to an embodiment of the present invention is shown.

[0075] like Figure 5 and Figure 6As shown, before use, a suitable-sized intranasal flexible support frame is selected based on the test subject's gender, height, weight, and other factors. Simultaneously, the appropriate size of the intranasal flexible support frame is selected in the customized software, and the specific method for calculating respiratory flow in the customized software is determined. During use, the intranasal flexible support frame (equipped with a gas flow sensor) is placed inside the nasal cavity, ensuring the support frame is the right size to stably support the nasal cartilage and is fixed inside the nasal cavity. Then, the integrated circuit module is activated through the customized software's interface to power the gas flow sensor. The gas flow sensor detects the respiratory signal, while the integrated circuit module collects, filters, amplifies, and stores the respiratory signal. The processed respiratory signal is then wirelessly transmitted via Bluetooth to the customized software, which is installed on mobile phones, tablets, laptops, or other operating media. After calculation by the customized software, the respiratory signal generates a curve representing respiratory gas flow and other related signals, which can be directly displayed on the operating media screen for real-time monitoring results. The results calculated by the customized software are transmitted to the integrated circuit module. The control unit of the integrated circuit module determines whether the breathing is abnormal or whether it belongs to a certain respiratory disease. If so, the control unit automatically drives the micro-pump to run, opens the valve to deliver the drug. The drug in the drug chamber is delivered to the inside of the nasal cavity through the drug delivery tubing, microtube and flexible ultrafine tube for drug delivery and treatment.

[0076] In addition, a memory card can be used to collect and store the respiratory signals processed by the integrated circuit module, and then transfer them to customized software.

[0077] The communication methods of this intranasal wearable dynamic respiratory flow intelligent monitoring and drug delivery system include, but are not limited to, the methods described above. Data cable transmission, wireless Bluetooth transmission, and data card transmission are all within the scope of protection of this application. Customized software for this intranasal wearable dynamic respiratory flow intelligent monitoring and drug delivery system includes, but is not limited to, mobile phone software, tablet software, and laptop software.

[0078] The intranasal wearable dynamic respiratory flow intelligent monitoring and drug delivery system can be used for respiratory disease screening, human nasal cycle monitoring, big data health monitoring, and can also be used for intranasal drug delivery therapy.

[0079] The use of an intranasal wearable dynamic respiratory flow intelligent monitoring and drug delivery system enables real-time respiratory monitoring and intranasal drug administration. It can be worn for extended periods and monitors respiratory signals, significantly expanding the amount of respiratory data collected, which is of great significance for the analysis and diagnosis of respiratory diseases. Furthermore, the intranasal wearable dynamic respiratory flow intelligent monitoring and drug delivery system is characterized by its ease of operation, low cost, high measurement accuracy, no location restrictions, and real-time result viewing, making it suitable for home use and beneficial for the early screening and treatment of respiratory diseases, thus possessing significant potential for widespread adoption. In addition, the intranasal wearable dynamic respiratory flow intelligent monitoring and drug delivery system also has the following characteristics:

[0080] It can independently and in real time measure the respiratory flow in both nasal cavities, intuitively reflecting changes in human tidal volume or nasal cycle, and can be used to conduct specific health assessments and develop personalized treatment plans.

[0081] The gas flow sensor used is made on a flexible ultra-fine tube, which can be inserted into the nasal cavity for measurement and is not easily affected by environmental airflow and other factors, and has extremely high signal measurement accuracy.

[0082] The intranasal wearing method can avoid interference from external environmental factors during the monitoring process, making the monitoring results more accurate and reliable;

[0083] The diverse intranasal flexible support design can adapt to the needs of different groups of people, and at the same time, it can correct the respiratory flow calculation method, making the measurement results more accurate.

[0084] While some embodiments of the present invention have been described in this application, those skilled in the art will understand that these embodiments are merely illustrative. Numerous variations, alternatives, and improvements will arise in those skilled in the art under the teachings of this invention without departing from its scope. The appended claims are intended to define the scope of the invention and thereby cover methods and structures within the scope of the claims themselves and their equivalents.

Claims

1. A wearable intranasal dynamic respiratory flow intelligent monitoring and drug delivery system, comprising: A flexible nasal support frame, which is configured to carry a gas flow sensor and can be fixed inside the nasal cavity; The size of the intranasal flexible support frame can be customized, and different sizes of intranasal flexible support frames can be selected according to the wearer's gender and height; the intranasal flexible support frame includes two support members and a connector connecting the two support members; the support members are elliptical; the connector is equipped with an integrated circuit module; The connector includes a connecting platform and connecting sidewalls located on both sides of the connecting platform; and a fixing bracket located on the connecting sidewalls of the connector, with the ring of the fixing bracket located in the middle of the end face of the support. A gas flow sensor is configured to detect respiratory signals and transmit them to an integrated circuit module, and is capable of delivering medication into the nasal cavity. The gas flow sensor includes a flexible ultrafine tube, a metal spiral coil on the surface of the flexible ultrafine tube, and an insulating layer covering the metal spiral coil. The flexible ultrafine tube is hollow. The gas flow sensor is fitted into a ring of a fixed bracket and fixed at the center of the support. The flexible ultrafine tube has a length of 6mm-10mm and a diameter of 0.3mm-1mm; and / or, when the flexible ultrafine tube is hollow, the wall thickness is 0.025mm-0.25mm; and / or the metal spiral coil wound on the flexible ultrafine tube has a spacing of 100um-300um and 5-20 turns; and / or the linewidth of the metal spiral coil is 10um-200um. An integrated circuit module is configured to power the gas flow sensor, receive, process, and store the respiratory signals collected by the gas flow sensor, determine whether there is abnormal breathing or a certain respiratory disease based on the calculation results of customized software, and drive the micropump drug delivery module to operate. The integrated circuit module includes: a respiratory signal acquisition module that acquires the respiratory signals detected by the gas flow sensor; a low-frequency filter that filters the respiratory signals to remove interference signals; an operational amplifier that amplifies the filtered respiratory signals; and a microcontroller that powers the gas flow sensor, stores the respiratory signals, and has a control unit. The control unit can determine whether there is abnormal breathing or a certain respiratory disease based on the calculation results of the customized software and drive the micropump of the micropump drug delivery module to operate. A micropump drug delivery module is configured to deliver drugs into the nasal cavity through a flexible ultrafine tube; and customized software is configured to control the operation of the intranasal wearable dynamic respiratory flow intelligent monitoring and drug delivery system, and to receive respiratory signals processed by the integrated circuit module for calculation and display of results, wherein the customized software is loaded on the operating medium. Based on the test subject's gender, height, and weight, the intranasal flexible support frame is selected, and the appropriate size of the intranasal flexible support frame is selected in the operation interface of the customized software. The method for calculating respiratory flow is then determined.

2. The intranasal wearable dynamic respiratory flow intelligent monitoring and drug delivery system according to claim 1, characterized in that, The process of forming a metal spiral coil includes: arranging photoresist on the surface of the flexible ultrafine tube, then photolithographically etching a spiral circuit pattern, electroplating or depositing metal in the circuit pattern to form a metal spiral coil; and connecting the metal spiral coil to the integrated circuit module via leads.

3. The intranasal wearable dynamic respiratory flow intelligent monitoring and drug delivery system according to claim 1, characterized in that, The micropump drug delivery module includes a microtube and a micropump, wherein the microtube is connected to the flexible ultrafine tube; The micropump includes: Medicine chamber, used to store medicines; The drug delivery tubing is equipped with a valve between itself and the drug chamber, and is connected to the flexible ultrafine tube; and The micropump is connected to the integrated circuit module via a signal or lead.

4. The intranasal wearable dynamic respiratory flow intelligent monitoring and drug delivery system according to claim 3, characterized in that, The integrated circuit module is mounted on the connector.

5. The intranasal wearable dynamic respiratory flow intelligent monitoring and drug delivery system according to claim 4, characterized in that, The intranasal flexible support frame is placed inside the nasal cavity; The integrated circuit module is activated through the user interface of the customized software to power the gas flow sensor. The gas flow sensor detects the breathing signal, and the integrated circuit module collects, filters, amplifies, and stores the breathing signal. The respiratory signal processed by the integrated circuit module is transmitted to the customized software; The customized software analyzes and calculates the respiratory signal, generates a respiratory gas flow signal curve, and displays it on the screen of the operating medium. At the same time, it transmits the calculation results to the control unit of the integrated circuit module. The control unit determines whether there is abnormal breathing or a certain respiratory disease. If there is abnormal breathing or a certain respiratory disease, the control unit drives the micropump to operate, opens the valve, and delivers the drug in the drug chamber to the inside of the nasal cavity through the drug delivery tubing, the microtube, and the flexible ultrafine tube.

6. The intranasal wearable dynamic respiratory flow intelligent monitoring and drug delivery system according to claim 1, characterized in that, The support is elliptical, with a major axis of 8mm-11mm and a minor axis of 5mm-8mm at its end face; and / or the wall thickness of the support and the connector is 1mm-2mm; and / or the length of the connector is 6mm-9mm.

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