Electronic equipment, patch and detection system

Abstract

The present invention relates to the field of electronic technology and provides an electronic device, a patch, and a detection system. The system is capable of simplifying the patch's structure and reducing its cost. The detection system, used to detect physiological parameters, comprises a patch and an electronic device. The patch comprises a substrate, a first electrode interface, an adhesive layer, and a first microneedle. The first microneedle is provided with a first electrode, which is coupled to the first electrode interface. The electronic device comprises an electrochemical sensing circuit and a first external interface, which is coupled to the electrochemical sensing circuit. When the electronic device is worn with its back facing the human body, the first external interface is electrically connected to the first electrode interface, transmitting electrical signals between the patch and the electronic device.

Description

Technical Field

[0001] The present application relates to the field of electronic technology, and in particular to an electronic device, a patch, and a detection system. Background Art

[0002] Today, the number of diabetes patients worldwide has increased dramatically, and diabetes and its complications have brought a heavy burden to human health and social development.

[0003] To provide diabetics with a more convenient way to test their blood sugar, portable or wearable blood sugar testing products have emerged. Typically, these products consist of a lancet, a blood glucose meter, and test strips. To use a test strip, the user first pricks the fingertip with the lancet to obtain blood. Then, they dip a small amount of blood into the test strip. Finally, they insert the test strip into the meter. After about ten seconds, the blood sugar concentration is displayed on the meter's screen. These blood sugar testing products typically cannot continuously monitor blood sugar levels, and each measurement requires pricking the finger, which is painful for the patient.

[0004] At present, a blood glucose detection product includes a patch and a reader. The patch contains a needle-shaped glucose sensor electrode, a constant potential meter circuit module, a data processing module, and a transmission module. The patch can be worn on the human body to perform blood glucose detection. This blood glucose detection product can achieve continuous blood glucose detection, and it is not necessary to prick the finger every time a measurement is taken. However, the glucose sensor electrode of this patch needs to be inserted into the human skin. In order to avoid infection caused by long-term insertion of the glucose sensor electrode into the skin (or failure of the glucose sensor electrode due to normal use), the patch usually has a certain service life after being applied to the patient's abdomen. For example, it needs to be replaced every 3 to 5 days. Therefore, as a consumable, the patch integrates the glucose sensor electrode, the constant potential meter circuit module, the data processing module, and the transmission module at the same time; this makes the structure of the patch more complicated, and increases the cost of use. Summary of the Invention

[0005] The embodiments of the present application provide an electronic device, a patch, and a detection system, which can simplify the structure of the patch and reduce the cost of use.

[0006] To achieve the above objectives, this application adopts the following technical solutions:

[0007] In a first aspect, a detection system is provided. The detection system is used to detect physiological parameters, such as blood sugar, blood lipids, blood oxygen, and other physiological parameters. The detection system includes a patch and an electronic device; wherein the patch includes: a substrate, a first electrode interface, an adhesive layer, and a first microneedle; the first electrode interface is arranged on the first surface of the substrate; the adhesive layer is arranged on the second surface of the substrate, and the second surface is opposite to the first surface; the first microneedle is arranged on the second surface of the substrate; wherein the first microneedle is provided with a first electrode, and the first electrode is coupled to the first electrode interface; the electronic device includes: an electrochemical sensing circuit and a first external interface; the first external interface is arranged on the back of the electronic device, wherein the first external interface is coupled to the electrochemical sensing circuit; wherein, when the back of the electronic device is worn toward the human body, the first external interface is electrically connected to the first electrode interface, and transmits electrical signals between the patch and the electronic device. In this way, when the patch is applied to the human body, the first microneedle penetrates the dermis of the human body, so that the first electrode can contact the blood in the dermis; when the electronic device is worn on the human body (for example, on the wrist), the first external interface on the electronic device forms an electrical connection with the first electrode interface of the patch; electrical signals can be transmitted between the patch and the electronic device; in this way, when the components in the blood (for example, glucose, oxygen, blood lipids, etc.) produce an electrochemical reaction on the first electrode and form an electrical signal, the electrochemical sensing circuit connected to the first external interface on the electronic device can detect the electrical signal formed by the electrochemical reaction, and then convert the electrical signal into a detection signal to realize the detection of physiological parameters. In this way, since circuit modules such as electrochemical sensing circuit, data processing module, transmission module, etc. are not set on the patch, the structure of the patch is simplified, thereby reducing the cost of use.

[0008] In one possible implementation, a second electrode is further provided on the first microneedle, and the patch further includes: a second electrode interface, the second electrode interface is provided on the first surface of the substrate; wherein the second electrode is coupled to the second electrode interface; the electronic device further includes a second external interface, the second external interface is provided on the back of the electronic device, wherein the second external interface is coupled to the electrochemical sensing circuit; wherein, when the back of the electronic device is worn toward the human body, the second external interface is electrically connected to the second electrode interface, and transmits electrical signals between the patch and the electronic device. Wherein, for the detection of different physiological parameters, it may be necessary to implement it through one or more electrodes, in which case one or more electrodes can be provided on the first microneedle. For example, for blood sugar detection, two different electrodes can be provided on the first microneedle, for example, a first electrode and a second electrode, and the first electrode and the second electrode can be a working electrode and a reference electrode, respectively. Of course, for blood sugar detection, three electrodes can also be provided on the first microneedle, for example, a counter electrode can also be provided.

[0009] In one possible implementation, the patch further comprises: a second microneedle and a second electrode interface; the second microneedle is disposed on the second surface of the substrate; the second electrode interface is disposed on the first surface of the substrate; wherein the second microneedle is provided with a second electrode, and the second electrode is coupled to the second electrode interface; the electronic device further comprises a second external interface, the second external interface is disposed on the back of the electronic device, wherein the second external interface is coupled to the electrochemical sensing circuit; wherein, when the back of the electronic device is worn facing the human body, the second external interface is electrically connected to the second electrode interface and transmits electrical signals between the patch and the electronic device. The detection of different physiological parameters may require one or more electrodes, in which case multiple microneedles may be provided, such as a second microneedle disposed on the second surface of the substrate, and a second electrode disposed on the second microneedle; for example, for blood glucose detection, a first electrode may be provided on the first microneedle, and a second electrode may be provided on the second microneedle, and the first electrode and the second electrode may be different, such as the first electrode and the second electrode may be a working electrode and a reference electrode, respectively. Of course, for blood glucose detection, the patch may also include a counter electrode, which may be disposed on the first electrode or the second electrode, or the counter electrode may be disposed separately on a third microneedle on the second surface of the substrate.

[0010] In one possible implementation, the first electrode interface and the second electrode interface are magnetic, or the first electrode interface and the second electrode interface are made of magnetic material; the first external interface and the second external interface are magnetic, or the first external interface and the second external interface are made of magnetic material. For example, the first external interface and the first electrode interface (the second external interface and the second electrode interface) can be made of magnetic materials such as neodymium iron boron, samarium cobalt, aluminum nickel cobalt, and iron chromium cobalt, and a magnetic field can be used to magnetize the magnetic material so that the magnetic material has magnetism. In order to ensure the reliability of the electrical connection between the first external interface of the electronic device and the first electrode interface of the patch (between the second external interface and the second electrode interface of the patch), the first external interface and the first electrode interface can be attracted together (the second external interface can be attracted together with the second electrode interface of the patch). Specifically, the first external interface and the first electrode interface (the second external interface and the second electrode interface) can both be magnetic (for example, opposite magnetism), or one can be magnetic and the other can be made of magnetic material. In addition, when the first external interface and the first electrode interface (the second external interface and the second electrode interface) are both made of magnetic materials, one or more layers of high-conductivity materials such as nickel and copper can be made on the surfaces where the first external interface and the first electrode interface (the second external interface and the second electrode interface) are in contact using processes such as electroplating or metal deposition to increase the conductivity of the first external interface and the first electrode interface (the second external interface and the second electrode interface). In this way, since the first external interface and the first electrode interface (the second external interface and the second electrode interface) are attracted by weak magnetism to ensure the reliability of the electrical connection between the two, when an external force disturbs the electronic device, the first external interface and the first electrode interface (the second external interface and the second electrode interface) can be separated, thereby preventing the disturbance of the electronic device from causing the patch to scratch the human skin.

[0011] In one possible implementation, the patch further includes a water barrier disposed on the first surface of the substrate, wherein the water barrier surrounds the first electrode interface. Thus, when the water barrier is attached to the electronic device, a sealed space is formed between the back of the electronic device and the substrate, preventing conductive liquids such as water or sweat from affecting the first electrode interface. For example, when a second electrode interface is provided on the patch, the conductive liquid may short-circuit the first and second electrode interfaces, thereby affecting the reliability of physiological parameter detection.

[0012] In one possible implementation, the patch further includes an application mark disposed on the first surface of the substrate, the application mark being used to indicate the application direction of the patch. For example, when the patch is applied to the skin, the application mark indicates that the patch should be applied in the direction between the ring finger and the middle finger. This ensures that the first external interface on the electronic device and the first electrode interface of the patch (or the second external interface and the second electrode interface of the patch) are correctly connected.

[0013] In one possible implementation, the first electrode interface and the second electrode interface are concentrically arranged circular electrode interfaces; and the first external interface and the second external interface are concentrically arranged circular external interfaces. It is understandable that when the first electrode interface and the second electrode interface of the patch are concentrically arranged circular electrode interfaces, and the first external interface and the second external interface of the corresponding electronic device are concentrically arranged circular external interfaces, no matter how the electronic device is rotated about an axis perpendicular to the center of the ring, the normal connection between the first external interface and the first electrode interface (or the second external interface and the second electrode interface) will not be affected.

[0014] In one possible implementation, the shape of the first electrode includes: columnar, planar, or winding. Of course, when there are other electrodes on the patch, the above shapes can also be used.

[0015] In one possible implementation, the first electrode includes one or more of the following materials: lamp black carbon, glassy carbon, graphite, silver, silver chloride, platinum, palladium, platinum-iridium alloy, titanium, gold, and iridium. Of course, when other electrodes are present on the patch, the above materials may also be used. In particular, the reference electrode RE may be made of silver or silver chloride. Since silver or silver chloride electrodes have very low solubility, extremely high stability and reversibility in aqueous solution systems, and the electrode surface is well protected even in the presence of hydrogen, when used as a reference electrode, the electrode self-noise can be minimized.

[0016] In one possible implementation, to ensure rapid implantation, minimal pain, and minimal wound, and to ensure that the microneedles are long enough to be inserted subcutaneously, the length of the first microneedle is 1-5 mm, and the diameter of the first microneedle is 7-400 μm. Of course, when the patch has other microneedles (such as a second microneedle), the above-mentioned first microneedle dimensions can also be used.

[0017] In one possible implementation, the material of the first microneedle includes stainless steel, platinum or a polymer material. Of course, when there are other microneedles (such as second microneedles) on the patch, the material of the first microneedle can also be used.

[0018] In one possible implementation, the patch further includes: a first magnetic interface, the first magnetic interface being provided on the first surface of the base; the first magnetic interface being magnetic, or the first magnetic interface being a magnetic material; the electronic device further includes: a second magnetic interface being provided on the back of the electronic device, the second magnetic interface being magnetic, or the second magnetic interface being a magnetic material; when the back of the electronic device is worn facing the human body, the first magnetic interface and the second magnetic interface are attracted to each other. For example: a first magnetic interface can be provided on the first surface of the base of the patch, the first magnetic interface being magnetic, or the first magnetic interface being a magnetic material. A second magnetic interface can be provided on the electronic device, the second magnetic interface being magnetic, or the second magnetic interface being a magnetic material. One side of the second magnetic interface is exposed outside the electronic device. Specifically, the first magnetic interface and the second magnetic interface can both be magnetic (e.g., opposite magnetic), or one can be magnetic and the other can be a magnetic material. The positions of the first magnetic interface and the second magnetic interface correspond one to one, and after the electronic device and the patch are attracted together through the first magnetic interface and the second magnetic interface, the first external interface and the first electrode interface (the second external interface and the second electrode interface) are electrically connected.

[0019] In a second aspect, a patch is provided for detecting physiological parameters, comprising: a substrate; a first electrode interface, the first electrode interface being arranged on the first surface of the substrate, the first electrode interface being used to transmit electrical signals between the patch and the electronic device after being electrically connected to the electronic device; an adhesive layer, the adhesive layer being arranged on the second surface of the substrate, the second surface facing away from the first surface; a first microneedle, the first microneedle being arranged on the second surface of the substrate; wherein a first electrode is arranged on the first microneedle, and the first electrode is coupled to the first electrode interface.

[0020] In one possible implementation, a second electrode is further provided on the first microneedle, and the patch further includes: a second electrode interface, which is provided on the first surface of the substrate; wherein the second electrode is coupled to the second electrode interface.

[0021] In one possible implementation, the patch also includes: a second microneedle, which is arranged on the second surface of the substrate; and a second electrode interface, which is arranged on the first surface of the substrate; wherein a second electrode is arranged on the second microneedle, and the second electrode is coupled to the second electrode interface.

[0022] In one possible implementation, the first electrode includes any one of a working electrode and a reference electrode.

[0023] In one possible implementation, the second electrode includes any one of a working electrode and a reference electrode, wherein the second electrode is different from the second electrode.

[0024] In a possible implementation, the first electrode interface and the second electrode interface are magnetic, or the first electrode interface and the second electrode interface are made of magnetic material.

[0025] In one possible implementation, the patch further includes: a water barrier bar, which is disposed on the first surface of the substrate, wherein the water barrier bar surrounds the first electrode interface.

[0026] In one possible implementation, the patch further includes: an application mark, which is disposed on the first surface of the substrate and is used to indicate an application direction of the patch.

[0027] In one possible implementation, the first electrode interface and the second electrode interface are concentrically arranged annular electrode interfaces.

[0028] In one possible implementation, the shape of the first electrode includes: columnar, planar, or winding.

[0029] In one possible implementation, the first electrode includes one or more of the following materials: lamp black carbon, glassy carbon, graphite, silver, silver chloride, platinum, palladium, platinum-iridium alloy, titanium, gold, and iridium.

[0030] In a possible implementation, the length of the first microneedle is 1-5 mm, and the diameter of the first microneedle is 7-400 μm.

[0031] In one possible implementation, the material of the first microneedle includes stainless steel, platinum, or a polymer material.

[0032] In a possible implementation, it further includes: a first magnetic interface, which is arranged on the first surface of the substrate; the first magnetic interface is magnetic, or the first magnetic interface is made of magnetic material.

[0033] In a third aspect, an electronic device is provided for detecting physiological parameters, comprising: an electrochemical sensing circuit; a first external interface, the first external interface being arranged on the back of the electronic device, wherein the first external interface is coupled to the electrochemical sensing circuit; wherein, when the electronic device is worn with the back facing the human body, the first external interface is electrically connected to the first electrode interface on the patch, and transmits electrical signals between the patch and the electronic device.

[0034] In a possible implementation, the first external connection interface is magnetic, or the first external connection interface is made of magnetic material.

[0035] In one possible implementation, the electronic device also includes a second external interface, which is arranged on the back of the electronic device, wherein the second external interface is coupled to the electrochemical sensing circuit; wherein, when the back of the electronic device is worn facing the human body, the second external interface is electrically connected to the second electrode interface of the patch, and transmits electrical signals between the patch and the electronic device.

[0036] In one possible implementation, the device further includes: a second magnetic interface disposed on the back of the electronic device, the second magnetic interface being magnetic, or being made of magnetic material.

[0037] In a possible implementation, the first external connection interface and the second external connection interface are concentrically arranged annular external connection interfaces.

[0038] In a fourth aspect, a method for detecting an in-situ patch is provided, which is applied to the detection system of the first aspect, and includes: determining the connection status of the patch based on the detection signal output by the electrochemical sensor; when it is determined that the intensity of the detection signal is less than or equal to the signal threshold, generating a first prompt message, wherein the first prompt message is used to prompt the user to adjust the wearing position of the electronic device. Since the detection signal output by the electrochemical sensor circuit can reflect the connection status between the first external interface on the electronic device and the first electrode interface of the patch, for example, if the intensity of the detection signal is zero, it indicates that the first external interface on the electronic device is completely disconnected from the first electrode interface of the patch, or if the detection signal output is greater than 0 but less than the signal threshold, it indicates that the first external interface on the electronic device is in poor contact with the first electrode interface of the patch, and there is a high impedance contact problem. At this time, it is necessary to adjust the wearing posture of the electronic device to re-electrically connect the first external interface on the electronic device to the first electrode interface of the patch.

[0039] In a possible implementation, the method further includes: when it is determined that the intensity of the detection signal is greater than the signal threshold, generating second prompt information, wherein the second prompt information is used to prompt the user to start physiological parameter detection.

[0040] In one possible implementation, the first prompt information includes: vibration, sound, or display information.

[0041] In a fifth aspect, an electronic device comprises a memory and one or more processors; the memory and the processor are coupled; the memory is used to store computer program code, and the computer program code comprises computer instructions; when the processor executes the computer instructions, the electronic device executes a method as described in any one of the fourth aspects.

[0042] In a sixth aspect, a computer-readable storage medium is provided, comprising computer instructions, which, when executed on an electronic device, enable the electronic device to execute any one of the methods in the third aspect.

[0043] Among them, the technical effects that can be achieved in the second to sixth aspects are similar to those in the first aspect and will not be repeated here. BRIEF DESCRIPTION OF THE DRAWINGS

[0044] Figure 1 A schematic diagram of the structure of a blood glucose detection product provided by the prior art;

[0045] Figure 2 A schematic diagram of a detection system according to an embodiment of the present application;

[0046] Figure 3 A schematic diagram of a detection system according to another embodiment of the present application;

[0047] Figure 4 A schematic structural diagram of an electronic device provided in an embodiment of the present application;

[0048] Figure 5 A schematic structural diagram of a patch provided in an embodiment of the present application;

[0049] Figure 6 A schematic structural diagram of an electronic device provided in another embodiment of the present application;

[0050] Figure 7 A schematic structural diagram of an electrochemical sensing circuit provided in an embodiment of the present application;

[0051] Figure 8 A schematic structural diagram of a patch provided in another embodiment of the present application;

[0052] Figure 9 A schematic structural diagram of a patch provided in yet another embodiment of the present application;

[0053] Figure 10 A schematic structural diagram of a patch provided in yet another embodiment of the present application;

[0054] Figure 11 A schematic structural diagram of a patch provided in another embodiment of the present application;

[0055] Figure 12 A schematic diagram of the structure of a microneedle provided in an embodiment of the present application;

[0056] Figure 13 A schematic structural diagram of a microneedle provided in another embodiment of the present application;

[0057] Figure 14 A schematic structural diagram of a microneedle provided in yet another embodiment of the present application;

[0058] Figure 15A schematic structural diagram of a microneedle provided in yet another embodiment of the present application;

[0059] Figure 16 A schematic structural diagram of a microneedle provided in another embodiment of the present application;

[0060] Figure 17 A schematic structural diagram of a microneedle provided in yet another embodiment of the present application;

[0061] Figure 18 A schematic structural diagram of a patch provided in yet another embodiment of the present application;

[0062] Figure 19 A schematic structural diagram of a patch provided in yet another embodiment of the present application;

[0063] Figure 20 A schematic structural diagram of a patch provided in another embodiment of the present application;

[0064] Figure 21 A schematic structural diagram of a patch provided in yet another embodiment of the present application;

[0065] Figure 22 A schematic structural diagram of a patch provided in yet another embodiment of the present application;

[0066] Figure 23 A schematic structural diagram of a patch provided in another embodiment of the present application;

[0067] Figure 24 A schematic structural diagram of a patch provided in yet another embodiment of the present application;

[0068] Figure 25 A schematic structural diagram of a microneedle provided in yet another embodiment of the present application;

[0069] Figure 26 A schematic structural diagram of an electronic device provided in yet another embodiment of the present application;

[0070] Figure 27 A schematic structural diagram of an electronic device provided in yet another embodiment of the present application;

[0071] Figure 28 A schematic structural diagram of a patch provided in yet another embodiment of the present application;

[0072] Figure 29 A schematic structural diagram of a patch provided in another embodiment of the present application;

[0073] Figure 30 A schematic structural diagram of a patch provided in yet another embodiment of the present application;

[0074] Figure 31 A schematic structural diagram of a patch provided in yet another embodiment of the present application;

[0075] Figure 32 A schematic structural diagram of an electronic device provided in another embodiment of the present application;

[0076] Figure 33 A schematic structural diagram of a patch provided in another embodiment of the present application;

[0077] Figure 34 A schematic structural diagram of a patch provided in yet another embodiment of the present application;

[0078] Figure 35 A schematic structural diagram of a coating layer of a working electrode provided in an embodiment of the present application;

[0079] Figure 36 A schematic diagram of the working principle of a coating of a working electrode provided in an embodiment of the present application;

[0080] Figure 37 A schematic structural diagram of a coating layer of a working electrode provided in another embodiment of the present application;

[0081] Figure 38 A schematic diagram of the working principle of a coating of a working electrode provided in another embodiment of the present application;

[0082] Figure 39 A schematic flow chart of a method for detecting an in-situ patch according to an embodiment of the present application;

[0083] Figure 40 A display interface diagram of a smart watch provided in an embodiment of the present application Figure 1 ;

[0084] Figure 41 A display interface diagram of a smart watch provided in an embodiment of the present application Figure 2 ;

[0085] Figure 42 A display interface diagram of a smart watch provided in an embodiment of the present application Figure 3 ;

[0086] Figure 43 A display interface diagram of a smart watch provided in an embodiment of the present application Figure 4 ;

[0087] Figure 44 A display interface diagram of a smart watch provided in an embodiment of the present application Figure 5 ;

[0088] Figure 45A display interface diagram of a smart watch provided in an embodiment of the present application Figure 6 ;

[0089] Figure 46 A schematic structural diagram of an electronic device provided in yet another embodiment of the present application;

[0090] Figure 47 A schematic structural diagram of a chip system provided in an embodiment of the present application. DETAILED DESCRIPTION

[0091] The technical solutions in the embodiments of the present application will be described below in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments.

[0092] Unless otherwise defined, all scientific and technological terms used herein have the same meaning as those known to those of ordinary skill in the art. In this application, "at least one" refers to one or more, and "a plurality" refers to two or more. "And / or" describes the association relationship of associated objects, indicating that three relationships may exist. For example, A and / or B can represent: the existence of A alone, the existence of A and B at the same time, and the existence of B alone, wherein A and B can be singular or plural. The character " / " generally indicates that the associated objects before and after are in an "or" relationship. "At least one of the following items" or its similar expressions refers to any combination of these items, including any combination of single items or plural items. For example, at least one of a, b or c can represent: a, b, c, a and b, a and c, b and c or a, b and c, wherein a, b and c can be single or multiple. In addition, in the embodiments of the present application, words such as "first" and "second" do not limit quantity and order.

[0093] In addition, in this application, directional terms such as "upper" and "lower" are defined relative to the orientation of the components in the drawings. It should be understood that these directional terms are relative concepts. They are used for relative description and clarification, and they can change accordingly according to changes in the orientation of the components in the drawings.

[0094] It should be noted that, in this application, words such as "exemplary" or "for example" are used to indicate examples, illustrations, or descriptions. Any embodiment or design described in this application as "exemplary" or "for example" should not be construed as being preferred or advantageous over other embodiments or designs. Rather, the use of words such as "exemplary" or "for example" is intended to present the relevant concepts in a concrete manner.

[0095] A blood glucose detection product includes a patch and a reader. The patch contains a needle-shaped glucose sensor electrode, a constant potential meter circuit module, a data processing module, and a transmission module. The patch can be worn on the human body, such as Figure 1 As shown, the patch 10 is directly applied to the patient's abdomen (of course, it can also be applied to other parts of the human body, such as the upper arm). In this way, the glucose sensing electrode can penetrate the patient's skin (for example, the glucose sensing electrode penetrates the epidermis of the skin and enters the dermis, coming into contact with the blood, so that the glucose in the blood produces an electrochemical reaction on the glucose sensing electrode). The constant potential meter circuit module can detect the electrical signal generated by the electrochemical reaction on the glucose sensing electrode, and convert the electrical signal into a digital signal through the data processing module. Finally, the transmission module converts the digital signal into a radio frequency signal and sends it to the reader 20 (which can be a smart wearable device, such as a watch, or a dedicated blood glucose meter). In this way, the reader 20 can obtain the blood glucose data of the patch and display it. Among them, the glucose sensing electrode of this patch 10 needs to be inserted into the human skin. In order to avoid infection caused by long-term insertion of the glucose sensing electrode into the skin (or failure of the glucose sensing electrode during normal use), the patch 10 usually has a certain service life after being applied to the patient's abdomen, for example, it needs to be replaced every 3 to 5 days at most. Therefore, as a consumable material, the patch 10 integrates the glucose sensor electrode, the potentiostat circuit module, the data processing module, and the transmission module at the same time; this makes the structure of the patch more complicated, thereby increasing the cost of use.

[0096] To solve the above problems, combined Figure 2 、 Figure 3 、 Figure 4 as well as Figure 5 The application scenario shown in the figure is briefly described as follows: The embodiment of the present application provides an electronic device, a patch and a detection system, which are mainly used for detecting any physiological parameter including blood sugar, blood lipids, blood oxygen, etc. In the embodiment of the present application, it is not necessary to set circuit modules such as electrochemical sensor circuits, data processing modules, transmission modules, etc. on the patch 10. Only microneedles 13 for inserting into human skin and electrodes 11 on the microneedles 13 are set on the patch 10. Figure 5 The three electrodes 11-1, 11-2 and 11-3 are shown in FIG; and the electrochemical sensing circuit 22 (such as Figure 4 As shown in FIG), a circuit module such as a data processing module is provided on an electronic device 20 (for example, a wearable device such as a smart watch), wherein the back of the electronic device 20 (as shown in FIG) Figure 3 As shown, the side facing the human body when normally worn) is provided with at least two external connection interfaces 21 ( Figure 4 Three external interfaces 21-1, 21-2, and 21-3 are shown in FIG. 1 . In addition, an electrode interface 12 ( Figure 5 In the figure, three electrode interfaces 12-1, 12-2, and 12-3 are shown. Thus, when the patch 10 is applied to the human body (e.g. Figure 5 As shown), the microneedle 13 penetrates the dermis of the human body, so that the electrode 11 can contact the blood in the dermis. When the electronic device 20 is worn on the human body (for example, the wrist, refer to Figure 3 As shown), the external interface 21 on the electronic device 20 is electrically connected to the electrode interface 12 of the patch 10 (as shown Figure 2 The electrical connection relationship is shown by the dotted line in the figure). Electrical signals can be transmitted between the patch 10 and the electronic device 20; in this way, the components in the blood (such as glucose, oxygen, blood lipids, etc.) produce electrochemical reactions on the electrode 11 to form electrical signals. Specifically, for measuring blood sugar, the glucose in the blood can produce an electrochemical reaction in the coating applied on the working electrode in the electrode 11 to form an electrical signal. As a result, the electrochemical sensing circuit 22 can detect the electrical signal formed by the electrochemical reaction, and the electronic device 20 then converts the electrical signal into a detection signal to detect physiological parameters. In this way, since circuit modules such as electrochemical sensing circuits, data processing modules, and transmission modules are not provided on the patch 10, the structure of the patch 10 is simplified, thereby reducing the cost of use. In some embodiments, at least one of the external interface 21 and the electrode interface 12 can be set as a magnetic interface. For example, a magnetic material can be used to attract the external interface 21 and the electrode interface 12 to ensure the reliability of the electrical connection between the two. Furthermore, when an external force disturbs the electronic device 20, the external interface 21 and the electrode interface 12 can be disengaged, preventing the disturbance of the electronic device 20 from causing the patch 10 to scratch the human skin. Of course, separate magnetic interfaces can also be provided on the electronic device 20 and the patch 10 to achieve attraction between the two. The above briefly describes the principles and main technical solutions of the products provided in the embodiments of this application. The following will describe them in detail with reference to specific examples.

[0097] For example, the electronic device in the embodiment of the present application may be a wearable device such as a smart watch, a smart wristband, a smart belt, etc. The embodiment of the present application does not impose any special restrictions on the specific form of the electronic device.

[0098] The following is a detailed description of the implementation of the embodiment of the present application with reference to the accompanying drawings. Figure 6 As shown in FIG, it is a structural diagram of an electronic device 20 provided in an embodiment of the present application. Figure 2As shown, the electronic device 20 may include: a processor 210, an external memory interface 220, an internal memory 221, a universal serial bus (USB) interface 230, a charging management module 240, a power management module 241, a battery 242, an antenna 1, an antenna 2, a mobile communication module 250, a wireless communication module 260, an audio module 270, a speaker 270A, a receiver 270B, a microphone 270C, an earphone interface 270D, a sensor module 280, a button 290, a vibration motor 291, an external interface 21, a camera 292, a display screen 293, a subscriber identification module (SIM) card interface 294, an electrochemical sensing circuit 22 and an indicator 295, etc.

[0099] It will be understood that the structure illustrated in this embodiment does not constitute a specific limitation on the electronic device 20. In other embodiments, the electronic device 20 may include more or fewer components than shown in the figure, or combine certain components, or split certain components, or arrange the components differently. The illustrated components can be implemented in hardware, software, or a combination of software and hardware. It will be understood that the interface connection relationship between the modules illustrated in this embodiment is merely a schematic illustration and does not constitute a structural limitation on the electronic device 20. In other embodiments, the electronic device 20 may also adopt different interface connection methods from the above embodiments, or a combination of multiple interface connection methods.

[0100] The processor 210 may include one or more processing units, for example: the processor 210 may include an application processor (AP), a modem processor, a graphics processing unit (GPU), an image signal processor (ISP), a controller, a memory, a video codec, a digital signal processor (DSP), a baseband processor, and / or a neural-network processing unit (NPU), etc. Among them, different processing units can be independent devices or integrated into one or more processors. The processor can be the nerve center and command center of the electronic device 20. The processor can generate operation control signals based on the instruction opcode and timing signal to complete the control of instruction fetching and execution.

[0101] Processor 210 may also include a memory for storing instructions and data. In some embodiments, the memory in processor 210 is a cache memory. This memory can store instructions or data that have just been used or are being recycled by processor 210. If processor 210 needs to use the same instruction or data again, it can directly retrieve it from the memory. This avoids duplicate accesses, reduces processor 210 latency, and thus improves system efficiency.

[0102] In some embodiments, the processor 210 may include one or more interfaces. The interfaces may include an inter-integrated circuit (I2C) interface, an inter-integrated circuit sound (I2S) interface, a pulse code modulation (PCM) interface, a universal asynchronous receiver / transmitter (UART) interface, a mobile industry processor interface (MIPI), a general-purpose input / output (GPIO) interface, a subscriber identity module (SIM) interface, and / or a universal serial bus (USB) interface.

[0103] The external memory interface 220 can be used to connect an external memory card, such as a Micro SD card, to expand the storage capacity of the electronic device 20. The external memory card communicates with the processor 210 via the external memory interface to implement data storage functions. For example, files such as music and videos can be stored on the external memory card.

[0104] The internal memory 221 can be used to store computer executable program code, which includes instructions. The processor 210 executes various functional applications and data processing of the electronic device 20 by running the instructions stored in the internal memory 221. For example, in an embodiment of the present application, the processor 210 can execute instructions stored in the internal memory 221, and the internal memory 221 can include a program storage area and a data storage area.

[0105] The program storage area may store an operating system, at least one application required for a function (such as a sound playback function, an image playback function, etc.), etc. The data storage area may store data created during the use of the electronic device 20 (such as audio data, a phone book, etc.). In addition, the internal memory 221 may include a high-speed random access memory and may also include a non-volatile memory, such as at least one disk storage device, a flash memory device, a universal flash storage (UFS), etc.

[0106] The charging management module 240 is configured to receive charging input from a charger. The charger can be either a wireless charger or a wired charger. In some wired charging embodiments, the charging management module 240 can receive charging input from the wired charger via the USB interface 230. In some wireless charging embodiments, the charging management module 240 can receive wireless charging input via the wireless charging coil of the electronic device 20. While charging the battery 242, the charging management module 240 can also provide power to the electronic device 20 via the power management module 241.

[0107] The power management module 241 is used to connect the battery 242, the charging management module 240, and the processor 210. The power management module 241 receives input from the battery 242 and / or the charging management module 240 and provides power to the processor 210, the internal memory 221, the external memory, the display 293, the camera 292, and the wireless communication module 260. The power management module 241 can also be used to monitor parameters such as battery capacity, battery cycle count, and battery health status (leakage, impedance). In some other embodiments, the power management module 241 can also be set in the processor 210. In other embodiments, the power management module 241 and the charging management module 240 can also be set in the same device.

[0108] The wireless communication function of the electronic device 20 can be implemented through the antenna 1, the antenna 2, the mobile communication module 250, the wireless communication module 260, the modem processor and the baseband processor.

[0109] Antenna 1 and antenna 2 are used to transmit and receive electromagnetic wave signals. Each antenna in electronic device 20 can be used to cover a single or multiple communication frequency bands. Different antennas can also be reused to improve antenna utilization. For example, antenna 1 can be reused as a diversity antenna for a wireless local area network. In other embodiments, the antennas can be used in conjunction with a tuning switch.

[0110] The mobile communication module 250 can provide solutions for wireless communications including 2G / 3G / 4G / 5G, etc., applied to the electronic device 20. The mobile communication module 250 can include at least one filter, a switch, a power amplifier, a low noise amplifier (LNA), etc.

[0111] The wireless communication module 260 can provide wireless communication solutions such as wireless local area networks (WLAN), Bluetooth (BT), global navigation satellite system (GNSS), frequency modulation (FM), near field communication (NFC), and infrared (IR) for use in the electronic device 20. For example, the WLAN can be a wireless fidelity (Wi-Fi) network.

[0112] Wireless communication module 260 can be one or more devices that integrate at least one communication processing module. Wireless communication module 260 receives electromagnetic waves via antenna 2, frequency-modulates and filters the electromagnetic wave signals, and transmits the processed signals to processor 210. Wireless communication module 260 can also receive signals to be transmitted from processor 210, frequency-modulate and amplify them, and then convert them into electromagnetic waves for radiation via antenna 2.

[0113] In some embodiments, the antenna 2 of the electronic device 20 is coupled to the mobile communication module 250 , and the antenna 2 is coupled to the wireless communication module 260 , so that the electronic device 20 can communicate with the network and other devices through wireless communication technology.

[0114] Electronic device 20 implements display functions through a GPU, display screen 293, and an application processor. The GPU is a microprocessor for image processing that connects display screen 293 and the application processor. The GPU is used to perform mathematical and geometric calculations for graphics rendering. Processor 210 may include one or more GPUs that execute program instructions to generate or modify display information. Display screen 293 may be a touchscreen for displaying images, videos, and the like. Display screen 293 includes a display panel.

[0115] The electronic device 20 can implement a camera function using an ISP, a camera 292, a video codec, a GPU, a display 293, and an application processor. The ISP is used to process data fed back by the camera 292. In some embodiments, the ISP can be located within the camera 292. The camera 292 is used to capture still images or video. In some embodiments, the electronic device 20 can include one or M cameras 292, where M is a positive integer greater than one.

[0116] The electronic device 20 can implement audio functions such as music playback and recording through the audio module 270, the speaker 270A, the receiver 270B, the microphone 270C, the headphone jack 270D, and the application processor.

[0117] Audio module 270 is used to convert digital audio information into analog audio signals for output, and also to convert analog audio input into digital audio signals. Headphone jack 270D is used to connect wired headphones. Headphone jack 270D can be a USB port 230, or a 3.5mm Open Mobile Terminal Platform (OMTP) standard interface or a Cellular Telecommunications Industry Association of the USA (CTIA) standard interface.

[0118] Among them, the above-mentioned sensor module 280 may include sensors such as a gyroscope sensor, an air pressure sensor, a magnetic sensor, an acceleration sensor, a distance sensor, a proximity light sensor, a fingerprint sensor, a temperature sensor, a touch sensor, an ambient light sensor and a bone conduction sensor.

[0119] The buttons 290 include a power button, a volume button, and the like. The buttons 290 may be mechanical buttons or touch buttons. The electronic device 20 may receive key inputs and generate key signal inputs related to user settings and function control of the electronic device 20.

[0120] The vibration motor 291, which can also be called a motor, can be used for vibration prompts. The vibration motor 291 can be used for incoming call vibration prompts. For example, touch operations acting on different applications (such as taking pictures, audio playback, etc.) can correspond to different vibration feedback effects. The vibration motor 291 can also correspond to different vibration feedback effects for touch operations acting on different areas of the display screen 293. Different application scenarios (for example: time reminders, receiving information, alarm clocks, games, etc.) can also correspond to different vibration feedback effects. The touch vibration feedback effect can also support customization.

[0121] The vibration motor 291, display screen 293, and speaker 270A in the embodiment of the present application can be used to display a first prompt message to the user prompting the user to adjust the wearing position of the electronic device 20, or a second prompt message to the user prompting to start physiological parameter detection.

[0122] The external interface 21 is used to connect to an external device. For example, in the patch provided in the embodiment of the present application, the external interface can be in the form of an electrode disk, an electrode block, or a conductive block protrusion, etc. The electronic device 20 can support 2 or N external interfaces, where N is a positive integer greater than 2.

[0123] The SIM card interface 294 is used to connect a SIM card. The SIM card can be connected to or disconnected from the electronic device 20 by inserting it into or removing it from the SIM card interface 294. The electronic device 20 can support 1 or N SIM card interfaces, where N is a positive integer greater than 1. The SIM card interface 294 can support Nano SIM cards, Micro SIM cards, SIM cards, and the like. It is understood that when the electronic device 20 is a wearable device that does not have mobile communication functions such as 2G / 3G / 4G / 5G, the SIM card interface 294 and the mobile communication module 250 may not be provided on the wearable device, that is, the SIM card interface 294 and the mobile communication module 250 may be optional components.

[0124] The electrochemical sensing circuit 22 may include an electrical signal detection circuit based on various electrochemical methods including amperometry, chronoamperometry, cyclic voltammetry, differential pulse voltammetry, and AC impedance spectroscopy. Figure 7As shown, a schematic diagram of the structure of an electrochemical sensing circuit 22 is provided, including an operational amplifier OP1 and an operational amplifier OP2, wherein the reverse terminal (-) of the operational amplifier OP1 is connected to the reference electrode (RE) of the patch 10, the output terminal of the operational amplifier OP1 is connected to the counter electrode (CE) of the patch 10, the reverse terminal (-) of the operational amplifier OP2 is connected to the output terminal of the operational amplifier OP2 through a resistor R, the reverse terminal (-) of the operational amplifier OP2 is also connected to the working electrode (WE) of the patch 10, and the positive terminal (+) of the operational amplifier OP2 is connected to the ground terminal GND. The function of the operational amplifier OP1 is feedback. Through the "virtual short" of the operational amplifier OP1, the voltage of RE is equal to the voltage ei input to the positive terminal (+) of the operational amplifier OP1. Moreover, the reverse terminal (-) of OP1 connected to RE is "virtual open" and no current flows, so that the current flows only between the two electrodes WE and CE; the function of OP2 is to realize mutual impedance amplification, converting the current flowing through WE and CE into a voltage eo through R. Of course, the patch 10 is described using a three-electrode configuration. When the patch 10 includes two electrodes, WE and CE, RE can be directly short-circuited with CE. Of course, the electrochemical sensor circuit 22 described above is an example of an electrochemical sensor circuit 22 for measuring blood sugar. When used for detecting other physiological parameters, the electrochemical sensor circuit 22 may also have other structures.

[0125] The indicator 295 may be an indicator light, which may be used to indicate the charging status, power level change, messages, missed calls, notifications, etc.

[0126] The electronic device with the above hardware structure in the following embodiments can be a wearable device. Take a smart watch as an example. Figure 4 As shown, the smart watch 20 includes an electrochemical sensing circuit 22 and a sensor circuit 23 provided on the back of the smart watch 20 (eg, Figure 2 The external interface 21 is coupled to the electrochemical sensing circuit 22. Figure 4 The electrochemical sensing circuit 22 in the embodiment can be Figure 6 The electrochemical sensing circuit 22, Figure 4 The external interface 21 can be Figure 6 The external interface 21 in.

[0127] When the back of the smart watch 20 is worn toward the human body, the external interface 21 (such as Figure 4 The three external interfaces 21-1, 21-2, and 21-3 are shown and the electrode interface 12 on the patch 10 (such as Figure 8The three electrode interfaces 12-1, 12-2, and 12-3 are shown as connected to transmit the electrical signal generated by the patch 10 to the electrochemical sensing circuit 22, which is used to convert the electrical signal into a detection signal. For example, the electrochemical sensing circuit 22 can specifically transmit the detection signal to the digital signal processor of the smart watch, which converts the detection signal into a display signal and outputs it to the display screen, thereby displaying the detected blood glucose value to the user. Specifically, in combination with the above Figure 7 The provided electrochemical sensing circuit 22, taking blood glucose detection as an example, the electrical signal generated by the patch 10 can specifically be the current flowing between the two electrodes WE and CE; the detection signal can specifically be the current flowing through WE and CE converted into a voltage eo; the digital signal processor can perform analog-to-digital conversion on the voltage eo and convert it into a display signal indicating the blood glucose (glucose) content in the blood (for example: 6.0 mg / dL (milligrams / deciliter)), and the blood glucose value is displayed on the display screen 293 through the display signal.

[0128] The embodiment of the present application also provides a patch for use with the above-mentioned smart watch 20, referring to Figure 8 As shown, the patch 10 includes a substrate 14, an electrode interface 12 arranged on the first surface of the substrate 14 (taking the patch 10 capable of realizing blood sugar detection as an example, including three electrodes, it is necessary to set three electrode interfaces 12-1, 12-2, and 12-3), an adhesive layer 15 arranged on the second surface of the substrate 14, and the second surface is opposite to the first surface; the patch 10 also includes a microneedle 13 arranged on the second surface of the substrate 14; wherein the microneedle 13 is provided with an electrode 11 (wherein Figure 8 Taking a microneedle 13 as an example, there are three electrodes 11-1, 11-2, and 11-3 on it. The electrodes provided on the microneedle 13 include at least a working electrode WE and a reference electrode RE, wherein the working electrode WE is coated with multiple coatings for physiological parameter detection. The electrodes 11 (11-1, 11-2, and 11-3) are coupled one-to-one with the electrode interface 12 (12-1, 12-2, and 12-3). Figure 8In the example of three electrodes, in addition to the working electrode WE and the reference electrode RE, the counter electrode CE is also included, wherein the working electrode WE, the reference electrode RE and the electrode CE can be any one of the electrodes 11 (11-1, 11-2, 11-3). For example, electrode 11-1 is the reference electrode RE, electrode 11-2 is the counter electrode, and electrode 11-3 is the working electrode WE. The material of the substrate 14 includes but is not limited to polyimide (PI), polyethylene terephthalate (PET), polydimethylsiloxane (PDMS), polyurethane (PU), etc.; the adhesive layer 15 is mainly used to stick the patch 10 to the skin to prevent it from falling off. The adhesive layer 15 can be made of skin-friendly materials, including but not limited to silicone gel.

[0129] Take two electrodes as an example to illustrate, refer to Figure 9 As shown, the working electrode WE and the reference electrode RE can be any one of the electrodes 11 (11-1, 11-2). For example, the electrode 11-1 is the reference electrode RE and the electrode 11-2 is the working electrode WE. Figure 10 and Figure 11 As shown, the electrode 11-1 is electrically connected to the electrode interface 12-1 through the wire L1, and the electrode 11-2 is electrically connected to the electrode interface 12-2 through the wire L2, wherein the wire L1 (L2) can be connected to the conductive structures at both ends by bonding.

[0130] Like this, when patch 10 is applied to human body (as Figure 5 As shown), the microneedle 13 penetrates the dermis of the human body, so that the electrode 11 can contact the blood in the dermis; when the smart watch 20 is worn on the human body (for example, the wrist), the external interface 21 on the smart watch 20 forms an electrical connection with the electrode interface 12 of the patch (as shown). Figure 2 The electrical connection relationship is shown by the dotted line, where a three-electrode patch is used as an example. Figure 4As shown, for example, the external interface 21-1 is electrically connected to the electrode interface 12-1, the external interface 21-2 is electrically connected to the electrode interface 12-2, and the external interface 21-3 is electrically connected to the electrode interface 12-3); electrical signals can be transmitted between the patch 10 and the electronic device 20; in this way, the components in the blood (such as glucose, oxygen, blood lipids, etc.) produce electrochemical reactions on the electrodes to form electrical signals. For example, for blood sugar detection, the glucose in the blood produces an electrochemical reaction on the coating coated on the working electrode WE in the electrode interface 12, forming an electrical signal. As a result, the electrochemical sensing circuit 22 can detect the electrical signal formed by the electrochemical reaction, and then convert the electrical signal into a detection signal to realize the detection of physiological parameters. In this way, since circuit modules such as electrochemical sensing circuits, data processing modules, and transmission modules are not provided on the patch 10, the structure of the patch 10 is simplified, thereby reducing the cost of use.

[0131] The shapes of the electrodes 11 include: columnar, planar or winding. Figure 12 As shown, the electrode 11-1, the electrode 11-2 and the electrode 11-3 can be three planar conductive structures arranged in sequence on the microneedle 13. Taking the patch 10 with two electrodes as an example, refer to Figure 13 As shown, the electrodes 11-1 and 11-2 can be two planar conductive structures arranged sequentially on the microneedles 13. In order to increase the contact area between the electrodes 11 and the dermis of the skin, as shown in FIG. Figure 14 、 Figure 15 As shown, each planar electrode can be arranged in two opposite directions along the axis of the microneedle. Figure 14 As shown, electrodes 11-1 and 11-2 are arranged on the same side along the axis of the microneedle, and electrode 11-3 is arranged on the other side along the axis of the microneedle. Figure 15 As shown, electrodes 11-1 and 11-2 are respectively arranged on both sides along the axis of the microneedle. In order to increase the contact area between the electrode and the dermis of the skin, the electrode can also be set in a columnar or winding shape, such as Figure 8 As shown, taking the three-electrode patch 10 as an example, the electrode 11-1, the electrode 11-2 and the electrode 11-3 can form three columnar conductive structures arranged in sequence on the microneedle 13, wherein Figure 8 As shown, the diameters of the electrodes are different. For example, the diameter of electrode 11-1 is larger than that of electrode 11-2, and the diameter of electrode 11-2 is larger than that of electrode 11-3. Figure 9 As shown, taking the patch 10 with two electrodes as an example, the electrodes 11-1 and 11-2 can form two columnar conductive structures arranged in sequence on the microneedle 13, wherein Figure 9As shown, the diameters of the electrodes are different, for example, the diameter of the electrode 11-1 is larger than the diameter of the electrode 11-2. Figure 16 As shown, taking the three-electrode patch 10 as an example, the electrode 11-1 can be wound around the microneedle 13 using a winding conductive structure, and the shapes of the other two electrodes are not limited. However, it should be noted that the winding electrode 11-1 needs to be insulated from the electrode 11-2 and the electrode 11-3. Figure 17 As shown, taking the two-electrode patch 10 as an example, the electrode 11-1 can be wound around the microneedle 13 using a winding conductive structure, and the shape of the other electrode is not limited. However, it should be noted that the winding electrode 11-1 needs to be insulated from the electrode 11-2.

[0132] Furthermore, the electrode materials include, but are not limited to, one or more of the following: lamp black carbon, glassy carbon, graphite, silver, silver chloride, platinum, palladium, platinum-iridium alloy, titanium, gold, and iridium. In particular, the reference electrode RE may be silver or silver chloride. Since silver or silver chloride electrodes have very low solubility in aqueous solutions, are extremely stable and reversible, and their surfaces are well protected even in the presence of hydrogen, their use as reference electrodes can minimize electrode self-noise.

[0133] The above description mainly takes the patch 10 having one microneedle as an example. In addition, the patch 10 may also have two or more microneedles, such as Figure 18 As shown, the patch 10 has two microneedles 13-1 and 13-2. Figures 19-22 As shown, the arrangement of electrodes of the patch 10 in the form of two electrodes and three electrodes on two microneedles is also provided. Figure 19 As shown, taking the patch 10 with two electrodes as an example, the electrode 11-1 can be set on the microneedle 13-1, and the electrode 11-2 can be set on the microneedle 13-2, wherein Figure 19 The electrode shape in the example is columnar, as mentioned above, the electrode shape can also be other shapes. Figure 20-22 As shown, taking the three-electrode patch 10 as an example, electrodes 11-1 and 11-2 can be set on microneedles 13-1, and electrode 11-3 can be set on microneedles 13-2. Alternatively, electrodes 11-1 and 11-3 can be set on microneedles 13-2, and electrode 11-2 can be set on microneedles 13-1. And so on. It is understood that there are other forms of setting three electrodes on two microneedles, which are not listed here. In addition, Figure 20 and Figure 21 Mainly taking the surface electrode as an example, Figure 22 The description is mainly made by taking a columnar electrode as an example. As mentioned above, the electrode shape may also be other shapes.

[0134] like Figure 23 As shown, the patch 10 has three microneedles (13-1, 13-2 and 13-3). Figure 34 As shown, taking the three-electrode patch 10 as an example, the electrode 11-1 can be set on the microneedle 13-1, the electrode 11-2 can be set on the microneedle 13-2, and the electrode 11-3 can be set on the microneedle 13-2. Figure 24 The electrode shape in the figure is columnar as an example. As mentioned above, the electrode shape can also be other shapes.

[0135] When patch 10 is applied to the skin, the microneedles must penetrate the epidermis and implant into the dermis above the subcutaneous tissue to ensure effective contact between the electrodes and the blood. Implantation can be done through active pressure, such as manually applying patch 10 to the back of the wrist to allow the microneedles to penetrate the subcutaneous tissue, or with the assistance of a needle inserter.

[0136] Among them, in order to ensure fast implantation, low pain, small wound surface, and ensure that the length of the microneedle is sufficient to be placed subcutaneously. Figure 25 As shown, the length L of the microneedle is 1-5 mm, and the diameter R of the microneedle is 7-400 μm. In addition, in the above example, the material of the microneedle 13 includes but is not limited to stainless steel, platinum or polymer materials. Combining the two methods of implanting microneedles, when the active pressing method is adopted, due to the different speeds of the user's movements, the microneedles are usually made of rigid materials, such as stainless steel. In addition, in order to ensure the requirements of fast implantation, low pain and small wound surface, the shape of the microneedle tip can be designed to be pine leaf-shaped. When the needle aid is used to assist the implantation, since the needle aid can have a higher insertion speed, the needle body can be made of flexible materials, such as polymer materials, platinum, etc. Since the needle aid can have a higher insertion speed, no special design is required for the tip of the microneedle.

[0137] In addition, the external interface 21 can be set to an interface with magnetic properties or a magnetic material, and the electrode interface 12 can be set to an interface with magnetic properties or a magnetic material. For example, the external interface 21 and the electrode interface 12 can be made of magnetic materials such as neodymium iron boron, samarium cobalt, aluminum nickel cobalt, and iron chromium cobalt, and a magnetic field can be used to magnetize the magnetic material so that the magnetic material has magnetic properties. In order to ensure the reliability of the electrical connection between the external interface 21 and the electrode interface 12, the external interface 21 and the electrode interface 12 can be attracted by magnetism. Specifically, the external interface 21 and the electrode interface 12 can both be magnetic (for example, opposite magnetism), or one can be magnetic and the other can be a magnetic material. In addition, when both the external interface 21 and the electrode interface 12 are made of magnetic materials, one or more layers of high conductivity materials such as nickel and copper can be made on the surface where the external interface 21 contacts the electrode interface 12 by electroplating or metal deposition to increase the conductivity of the external interface 21 and the electrode interface 12. In this way, since the external interface 21 and the electrode interface 12 are attracted by weak magnetism, the reliability of the electrical connection between the two can be ensured. When an external force disturbs the electronic device 20, the external interface 21 and the electrode interface 12 can be separated, avoiding the disturbance of the electronic device 20 causing the patch 10 to scratch the human skin.

[0138] Of course, you can also set up magnetic interfaces on the smart watch 20 and the patch 10 to achieve the attraction of the two. Figure 26 As shown, a second magnetic interface 23 corresponding to the external interface 21 can be set inside the smart watch 20 on the inner side of the external interface 21 (for example, taking the three-electrode patch 10 scenario as an example, a second magnetic interface 23-1 is set on the inner side of the external interface 21-1, a second magnetic interface 23-2 is set on the inner side of the external interface 21-2, and a second magnetic interface 23-3 is set on the inner side of the external interface 21-3), wherein the second magnetic interface 23 is magnetic, or the second magnetic interface 23 is made of magnetic material. In this way, when the electrode interface 12 is set as an interface with magnetic properties or adopts magnetic materials, the electronic device 20 and the patch 10 can be attracted together through the second magnetic interface 23 to ensure the reliability of the electrical connection between the external interface 21 and the electrode interface 12.

[0139] In addition, refer to Figure 27 、 Figure 28As shown, a first magnetic interface 16 can also be provided on the first surface of the base of the patch 10, and the first magnetic interface 16 has magnetism, or the first magnetic interface 16 is made of magnetic material. A second magnetic interface 23 is provided on the smart watch 20, and the second magnetic interface 23 has magnetism, or the second magnetic interface 23 is made of magnetic material. One side of the second magnetic interface 23 leaks out of the electronic device 20. Specifically, the first magnetic interface 16 and the second magnetic interface 23 can both have magnetism (for example, opposite magnetism), or one has magnetism and the other is made of magnetic material. The positions of the first magnetic interface 16 and the second magnetic interface 23 correspond one to one, and after the smart watch 20 and the patch 10 are attracted together through the first magnetic interface 16 and the second magnetic interface 23, the external interface 21 is electrically connected to the electrode interface 12. Specifically, taking the three-electrode patch 10 scenario as an example, the first magnetic interface 16-1 corresponds to and engages with the second magnetic interface 23-1, the first magnetic interface 16-2 corresponds to and engages with the second magnetic interface 23-2, and the first magnetic interface 16-3 corresponds to and engages with the second magnetic interface 23-3. Of course, the above is an example of a smart watch 20 including three second magnetic interfaces 23 and a patch 10 including three first magnetic interfaces 16. Since fixing two points on a surface can ensure that the plane cannot rotate along an axis perpendicular to the surface, in order to ensure the reliability of the electrical connection between the external interface 21 and the electrode interface 12, that is, to prevent the smart watch from rotating along an axis perpendicular to the display plane of the smart watch, causing the external interface 21 to be separated from the electrode interface 12, at least two second magnetic interfaces 23 with different positions need to be set on the smart watch 20, and at least two first magnetic interfaces 16 with different positions need to be set on the patch 10.

[0140] In addition, in order to ensure that the external interface 21 on the smart watch 20 forms a correct connection with the electrode interface 12 of the patch 10, for example, taking a three-electrode patch as an example, it is necessary to ensure that after the patch is applied to the skin, the external interface 21-1 of the smart watch is electrically connected to the electrode interface 12-1 of the patch, the external interface 21-2 is electrically connected to the electrode interface 12-2, and the external interface 21-3 is electrically connected to the electrode interface 12-3. An application mark 17 is provided on the first surface of the substrate 14, and the application mark 17 is used to indicate the application direction of the patch. Figure 29 As shown, when applying the patch to the skin, the application mark 17 indicates that the patch should be applied in the direction between the ring finger and the middle finger.

[0141] In another example, the electrode interface of the patch is a concentrically arranged circular electrode interface, and the corresponding external interface of the smart watch is a concentrically arranged circular external interface. Figure 30 、 Figure 31The electrode interface 12-1 and the electrode interface 12-2 can be concentrically arranged circular electrode interfaces; the electrode interface 12-1 is coupled to the electrode 11-1 through the wire L1, and the electrode interface 12-2 is coupled to the electrode 11-2 through the wire L2. Figure 32 As shown, the external interface 21-1 and the external interface 21-1 can be concentrically arranged circular external interfaces; after the smart watch 20 is attached to the patch 10, the electrode interface 12-1 is electrically connected to the external interface 21-1, and the electrode interface 12-2 is electrically connected to the external interface 21-2.

[0142] In another example, the patch further includes a water barrier disposed on the first surface of the substrate, wherein the water barrier surrounds the electrode interface. Figure 33 and Figure 34 As shown, the water barrier 18 is provided on the first surface of the base 14, and the water barrier 18 surrounds at least two electrode interfaces 12 for a circle. In this way, when the water barrier 18 is fitted with the smart watch 20, a closed space can be formed between the back of the smart watch 20 and the base 14 to prevent conductive liquids such as water or sweat from entering and affecting the electrode interfaces. For example, when a plurality of electrode interfaces are provided on the patch, the conductive liquid may short-circuit the plurality of electrode interfaces, thereby affecting the reliability of physiological parameter detection. Of course, the water barrier 18 in the figure is shown as a circular ring. It can be understood that this application does not require the shape of the water barrier 18, such as other closed ring-shaped figures. Of course, in some examples, the water barrier can also be directly provided on the back of the smart watch 20, so there is no need to provide a water barrier on each patch, which can further reduce costs.

[0143] In addition, in some examples, various different film layers need to be modified on the working electrode surface of the microneedle to achieve effective physiological parameter detection. For example, in glucose detection (i.e., blood sugar detection), in order to successfully convert the chemical signal of glucose into an electrical signal, the following lists the film layers that may appear on the working electrode surface and their corresponding functions.

[0144] Reference Figure 35As shown, the working electrode is sequentially stacked with a base layer, an anti-interference layer, a glucose oxidase layer, an analyte modulating layer, and a biocompatibility layer. The biocompatibility layer improves affinity with tissues in the body, reduces contamination from immune and protein adhesion, and increases the effective lifespan of the patch. Common materials for the biocompatibility layer include, but are not limited to, hydrogels and polylactic acid-hydroxyethyl copolymers. The analyte modulating layer, also known as the glucose limiting layer, is a crucial component of the patch. While glucose concentrations in the body are generally high, the amount of glucose oxidase and oxygen present on the working electrode is minimal. To ensure an excess of glucose oxidase but not an excess of glucose, glucose permeation must be limited. The analyte modulating layer serves to limit the ratio of glucose inside and outside the membrane. This ratio typically ranges from 1:1 to tens of thousands to one. Common materials for the analyte modulating layer include monovinylpyridine-polyethylene glycol copolymer, polyurethane (PU), and poly-2-hydroxyethyl methacrylate. The glucose oxidase layer contains glucose oxidase (systematic name: β-D-glucose oxidoreductase, full English name: glucoseoxidase, abbreviated as GOx or GOD), which is modified by covalent cross-linking or dehydration condensation and is used to catalyze the oxidation of glucose; the anti-interference layer, in this example, glucose and oxygen react in the glucose oxidase layer to produce hydrogen peroxide; however, there are various interfering substances in human tissue fluid, which will interfere with the blood glucose detection of the patch. The anti-interference layer filters out these interfering substances and only allows hydrogen peroxide (H2O2) to pass, thereby avoiding or reducing this interference. Commonly used materials include but are not limited to perfluorosulfonic acid membrane (nafion); the function of the base layer is to modify the surface of the working electrode to facilitate the various coatings on the base layer to better adhere to the surface of the working electrode and connect more firmly. Commonly used materials for the base layer include but are not limited to polyvinyl pyridine derivatives, chitosan, glutaraldehyde, etc.

[0145] Reference Figure 36 And the following chemical formula 1, formula 2, formula 3 and formula 4 have Figure 35The working principle of the working electrode of the provided coating structure is described as follows: Oxygen O2 dissolved in the subcutaneous tissue fluid participates in the glucose oxidation process, passes through the biocompatible layer and the analyte regulating layer together with glucose, and reaches the glucose oxidase layer to react. First, glucose oxidase (GOx) catalyzes the oxidation of glucose to gluconolactone, and glucose oxidase changes from an oxidized state to a reduced state (as shown in Formula 1). In Formula 1, oxidized flavin adenine dinucleotide (FAD) is used as an oxidant to provide oxygen O2 and then reduced to reduced flavin adenine dinucleotide (FADH2). Subsequently, oxygen O2 oxidizes the reduced glucose oxidase to form hydrogen peroxide (H2O2) (as shown in Formula 2). In Formula 2, reduced flavin adenine dinucleotide (FADH2) is oxidized by oxygen O2 to oxidized flavin adenine dinucleotide (FAD). Formulas 1 and 2 are equivalent to Formula 3, that is, glucose and oxygen O2 generate gluconolactone and hydrogen peroxide (H2O2) under the catalysis of glucose oxidase GOx. Finally, hydrogen peroxide (H2O2) passes through the anti-interference layer and reaches the base layer, where it undergoes oxidation or reduction reaction under the voltage of the working electrode (0.6-0.7V), generating a current e - .

[0146] Among them, the coating of the working electrode includes but is not limited to the above-mentioned base layer, anti-interference layer, enzyme sensing layer, analyte regulating layer (semi-permeable membrane), biocompatible layer, etc. The order of each coating may be fine-tuned (for example, the anti-interference layer can be set between the analyte regulating layer and the biocompatible layer), or some coatings may be mixed into one layer for use.

[0147] GOx(FAD)+glucose→GOx(FADH2)+gluconolactone; Formula 1.

[0148] GOx(FADH2)+oxidant (O2)→GOx(FAD)+product (H2O2); Formula 2.

[0149]

[0150] In another embodiment, referring to Figure 37 As shown, the working electrode WE is sequentially stacked with a base layer, a redox medium layer, a glucose oxidase layer, an anti-interference layer, an analyte regulating layer, and a biocompatible layer. Except for the redox medium layer, the functions and materials of the other layers can be referred to. Figure 35The redox medium layer is a polymer chain material based on osmium complex (Os), which is used to transfer electrons at low potential and reduce the influence of interfering substances (such as ascorbic acid and uric acid). Figure 38 And the following chemical formulas 5, 6, 7 and 8 have Figure 37 The working principle of the working electrode of the provided coating structure is described as follows: Figure 35 The difference between the provided solutions is that oxygen O2 does not participate in the redox reaction, and the redox medium layer replaces oxygen. First, glucose passes through the biocompatible layer, the analyte regulating layer, and the anti-interference layer to reach the glucose oxidase layer. The oxidized glucose (GOx) oxidase catalyzes the oxidation of glucose into gluconolactone and is itself reduced to reduced glucose oxidase ((GOx) (as shown in Formula 5), ​​wherein the oxidized flavin adenine dinucleotide (FAD) is used as the oxidant to provide oxygen O2 and then reduced to reduced flavin adenine dinucleotide (FADH2); then, the oxidized electron intermediate (such as the complex Os) oxidizes the reduced glucose oxidase and becomes a reduced product (as shown in Formula 6), wherein the reduced flavin adenine dinucleotide (FAD) is used as the oxidant. FADH2 is oxidized by an oxidized electron intermediate to oxidized flavin adenine dinucleotide (FAD). Equations 5 and 6 are equivalent to Equation 7, which shows that glucose (glucose) and an oxidized electron intermediate (such as the complex Os) react under the catalysis of glucose oxidase (GOx) to produce gluconolactone and a reduced electron intermediate. Finally, a voltage is applied to the working electrode (WE). Due to the use of a redox mediator, oxygen does not participate in the reaction and no hydrogen peroxide is generated. Therefore, a very low voltage (0.2V) applied to the working electrode is sufficient to complete electron transfer. The reduced product is oxidized again, generating a current corresponding to the glucose concentration.

[0151] In this solution, the coatings on the working electrode include, but are not limited to, a base layer, a redox mediator layer, an enzyme sensing layer, an anti-interference layer, an analyte-modulating layer (semi-permeable membrane), and a biocompatible layer. The order of the coatings may be fine-tuned (for example, the anti-interference layer may be positioned between the biocompatible layer and the analyte-modulating layer), and some coatings may be combined into a single layer. In this embodiment, since oxygen does not participate in the reaction, interfering substances minimally interfere with the blood glucose detection of the patch, and therefore the anti-interference layer can be omitted.

[0152] GOx(FAD)+glucose→GOx(FADH2)+gluconolactone; Formula 5.

[0153] GOx(FADH2)+Os(oxidized state)→GOx(FAD)+Os(reduced state); Formula 6.

[0154]

[0155] Based on the above-mentioned smart watch and patch, since the smart watch is worn on the human body, the human body's movement smart watch itself will have a small disturbance. When the disturbance of the smart watch causes the connection between the external interface of the smart watch and the electrode interface of the patch to be disconnected, it may affect the normal detection of physiological parameters. Therefore, in order to ensure that the smart watch is worn on the human body, the external interface 21 on the smart watch 20 is electrically connected with the electrode interface 12 of the patch 10 to ensure normal detection of physiological parameters. In the embodiment of the present application, a patch in-situ detection method is provided, referring to Figure 39 As shown, the specific steps include:

[0156] 101. The smart watch obtains the detection signal output by the electrochemical sensor circuit.

[0157] The detection signal may be a signal with a certain signal strength, such as voltage or current.

[0158] 102. When it is determined that the strength of the detection signal is less than or equal to the signal threshold, the smart watch generates a first prompt message, where the first prompt message is used to prompt the user to adjust the wearing position of the smart watch.

[0159] 103. When it is determined that the strength of the detection signal is greater than the signal threshold, the smart watch generates a second prompt message, where the second prompt message is used to prompt the user to start physiological parameter detection.

[0160] The first prompt information and the second prompt information include: vibration, sound, or display information.

[0161] Since the detection signal output by the electrochemical sensor circuit can reflect the connection status between the external interface 21 on the smart watch 20 and the electrode interface 12 of the patch 10, for example, if the detection signal strength is zero, it indicates that the external interface 21 on the smart watch 20 and the electrode interface 12 of the patch 10 are completely disconnected. Alternatively, if the detection signal output is greater than 0 but less than the signal threshold, it indicates that the external interface 21 on the smart watch 20 and the electrode interface 12 of the patch 10 are in poor contact and have a high-impedance contact problem. In this case, it is necessary to adjust the wearing posture of the smart watch 20 to reconnect the external interface 21 on the smart watch 20 to the electrode interface 12 of the patch 10.

[0162] Specifically, using the complete blood glucose testing process as an example, the usage of the smartwatch 20 and patch 10 provided in the embodiments of this application is described as follows: First, the user applies the patch 10 to the back of the wrist by actively pressing or inserting it with an inserter; then, the smartwatch 20 is put on. Once properly worn, the external interface 21 on the smartwatch 20 establishes an electrical connection with the electrode interface 12 on the patch 10. The blood glucose testing function is then activated manually or automatically.

[0163] Exemplarily, the smart watch 20 may display a first interface and receive a first operation of the user on the first interface. The first operation is used to trigger the smart watch 20 to perform a blood glucose test. Specifically, the smart watch 20 may display a first interface of a first APP. The first interface may be used to trigger the smart watch 20 to perform a blood glucose test. For example, the first interface may display a trigger mark of "blood glucose test", indicating that the user can trigger a blood glucose test by clicking the "blood glucose test" mark. In addition, the blood glucose test mode may be further triggered, such as a single test mode or a continuous test mode. In the continuous test mode, parameters such as the test time interval may be further configured.

[0164] For example, the first APP in the embodiment of the present application can be as follows Figure 40 The icon "Health" corresponds to the application shown in the figure. Figure 40 As shown in , the smart watch 20 can receive a user's click operation on the icon "Health"; in response to the click operation, the smart watch 20 can start the first APP and display Figure 41 The first interface 411 may include a health management option, such as a "blood sugar test" option (control 4111 in the first interface 411), and the control 4111 is used to trigger the smart watch to test blood sugar. The above-mentioned first operation may be a user clicking operation (such as a single-click operation) on the control 4111 shown in the first interface 411, such as a click operation on the control 4111. Alternatively, the above-mentioned first operation may also be a user clicking on the first interface 411 (such as Figure 41 The smartwatch 20 may prompt the user of the preset gesture and the function triggered by the preset gesture (i.e., blood sugar measurement) on the first interface.

[0165] Specifically, when the user clicks the control 4111, in response to the user's click operation on the control 4111, the smart watch 20 displays the second interface 421 (such as Figure 42As shown, the second interface 421 displays "Measuring blood sugar" to prompt the user that the smart watch 20 is performing blood sugar testing), wherein, when the smart watch 20 displays the second interface 421, the smart watch 20 applies a constant voltage between the working electrode and the reference electrode of the patch 10 to start the formal blood sugar test. At this time, the coating of the working electrode will catalyze the oxidation of glucose and generate an electrical signal. The electrochemical sensing circuit in the watch can capture the electrical signal and convert it into a detection signal. Finally, the processor of the smart watch 20 processes and analyzes the detection signal through an algorithm and converts it into a glucose concentration (blood sugar value). In addition, after the smart watch 20 displays the second interface 421, the patch 10 can also be initialized first (wherein, the surface film layer will be filled with water for a period of time after the microneedle is inserted into the body (ranging from 1 hour to several hours), which is also called a hydration process. Only then can it return to stability. This process is the initialization of the patch 10), and execute the calibration algorithm or remind the user to calibrate through fingertip blood sugar. After generating the measurement results, the smart watch 20 displays the third interface 431 (as shown in FIG. Figure 43 As shown, the third interface 431 displays "Current blood glucose: 6.0 mg / dL". Of course, the third interface 431 can also provide an option for prompting the user to click to trigger a query of "previous measurement value" (control 4311). In addition, the first interface 411 can also include options such as "Mode Settings" (control 4112). Figure 41 The control 4112 in the first interface 411 shown in FIG. 4 is a control that, when the user clicks on the control 4112, the smart watch 20 displays the fourth interface 441 (eg, Figure 44As shown in FIG4 , the fourth interface 441 may provide an option for prompting the user to trigger a "continuous detection mode" (control 4411) or a "single detection mode" (control 4412). In response to a click on control 4411 or control 4412, the smart watch 20 may enter the corresponding detection mode. For example, in response to a click on control 4412, the smart watch 20 enters a single detection mode and completes a single blood glucose measurement; in response to a click on control 4411, the smart watch 20 enters a continuous detection mode and can continuously perform blood glucose measurements at user-configured time intervals. The above provides a complete blood glucose detection process with a specific example. In actual use, since the smart watch is worn on a part of the human body, the movement of the human body causes a small amplitude disturbance in the smart watch itself. When the disturbance of the smart watch causes the connection between the external interface of the smart watch and the electrode interface of the patch to be disconnected, it may affect the normal performance of the blood glucose detection. Therefore, after the user clicks control 4111 on the first interface 411, the smart watch obtains the detection signal output by the electrochemical sensor circuit. For example, it can be a current signal. When it is determined that the current intensity of the detection signal is less than or equal to the signal threshold (for example, the current intensity is zero or less than the signal threshold), a first prompt message is generated, for example, the fifth interface 451 (such as Figure 45 As shown, the specific fifth interface 451 display content may be "The electrodes are not in contact, please adjust the device position"). Of course, the first prompt information may also be the vibration emitted by driving the vibration motor 291, or the voice prompt emitted by the speaker 270A, or any two or a combination of the three. In this way, after the user adjusts the position according to the prompt, the smart watch continues to obtain the detection signal output by the electrochemical sensor circuit until it determines that the intensity of the detection signal is greater than the signal threshold, and generates a second prompt information, wherein the second prompt information is used to prompt the user to start blood glucose testing. The exemplary second prompt information can directly reuse the above-mentioned second interface 421 (such as Figure 42 Of course, voice or vibration prompts can also be provided at the same time.

[0166] For example, Figure 46 This is a schematic diagram of the structure of an electronic device provided in an embodiment of the present application, which can specifically implement the above Figure 39 The method shown in .

[0167] like Figure 46 As shown, the electronic device 20 includes: a signal detection module 201, a signal processing module 202. The above modules or components can communicate through one or more communication buses (I2C) or signal lines. It can be understood by those skilled in the art that Figure 46The modules or components shown in the figure do not constitute a limitation to the electronic device. The electronic device 20 may include more or fewer components than shown in the figure, or combine certain components, or arrange the components differently.

[0168] Signal detection module 201 is configured to determine the connection status of the patch based on the detection signal output by the electrochemical sensing circuit. Signal processing module 202 is configured to generate a first prompt message when it is determined that the strength of the detection signal obtained by signal detection module 201 is less than or equal to a signal threshold, wherein the first prompt message is configured to prompt the user to adjust the wearing position of the electronic device.

[0169] Optionally, the signal processing module 202 is further configured to generate a second prompt message when determining that the strength of the detection signal is greater than a signal threshold, wherein the second prompt message is used to prompt the user to start physiological parameter detection. The first prompt message and the second prompt message include: vibration, sound, or display information.

[0170] Some other embodiments of the present application provide an electronic device, which may include: the above-mentioned display screen (such as a touch screen), a memory and one or more processors. The display screen, the memory and the processor are coupled. The memory is used to store computer program code, and the computer program code includes computer instructions. When the processor executes the computer instructions, the electronic device can perform the various functions or steps performed by the electronic device in the above-mentioned method embodiment. The structure of the electronic device can refer to Figure 2 The structure of the electronic device 20 is shown.

[0171] The present application also provides a chip system. Figure 47 As shown, the chip system 30 includes at least one processor 301 and at least one interface circuit 302. The processor 301 and the interface circuit 302 can be interconnected via lines. For example, the interface circuit 302 can be used to receive signals from other devices (such as the memory of an electronic device). For another example, the interface circuit 302 can be used to send signals to other devices (such as the processor 301). Exemplarily, the interface circuit 302 can read instructions stored in the memory and send the instructions to the processor 301. When the instruction is executed by the processor 301, the electronic device can execute the various steps in the above embodiments. Of course, the chip system can also include other discrete devices, which is not specifically limited in the embodiments of the present application.

[0172] An embodiment of the present application also provides a computer-readable storage medium, which includes computer instructions. When the above-mentioned computer instructions are executed on the above-mentioned electronic device, the electronic device executes each function or step executed by the electronic device in the above-mentioned method embodiment.

[0173] An embodiment of the present application further provides a computer program product. When the computer program product is run on a computer, the computer is enabled to execute the functions or steps executed by the electronic device in the above method embodiment.

[0174] Through the description of the above implementation methods, technical personnel in the relevant field can clearly understand that for the convenience and simplicity of description, only the division of the above-mentioned functional modules is used as an example. In actual applications, the above-mentioned functions can be assigned to different functional modules as needed, that is, the internal structure of the device can be divided into different functional modules to complete all or part of the functions described above.

[0175] In the several embodiments provided in this application, it should be understood that the disclosed devices and methods can be implemented in other ways. For example, the device embodiments described above are merely schematic. For example, the division of the above modules or units is only a logical function division. In actual implementation, there may be other division methods, such as multiple units or components can be combined or integrated into another device, or some features can be ignored or not executed. Another point is that the mutual coupling or direct coupling or communication connection shown or discussed can be through some interfaces, indirect coupling or communication connection of devices or units, which can be electrical, mechanical or other forms.

[0176] Units described as separate components may or may not be physically separate, and components shown as units may be one physical unit or multiple physical units, that is, they may be located in one place or distributed in multiple places. Some or all of the units may be selected according to actual needs to achieve the purpose of the present embodiment.

[0177] In addition, the functional units in the various embodiments of the present application may be integrated into a single processing unit, or each unit may exist physically separately, or two or more units may be integrated into a single unit. The aforementioned integrated units may be implemented in the form of hardware or software functional units.

[0178] If the integrated unit is implemented in the form of a software functional unit and sold or used as an independent product, it can be stored in a readable storage medium. Based on this understanding, the technical solution of the embodiment of the present application is essentially or the part that contributes to the prior art or all or part of the technical solution can be embodied in the form of a software product, which is stored in a storage medium and includes several instructions for enabling a device (which can be a single-chip microcomputer, chip, etc.) or a processor to execute all or part of the steps of the method in each embodiment of the present application. The aforementioned storage medium includes: various media that can store program codes, such as a USB flash drive, a mobile hard disk, a read-only memory (ROM), a random access memory (RAM), a magnetic disk or an optical disk.

[0179] The above content is only a specific embodiment of this application, but the scope of protection of this application is not limited to this. Any changes or replacements within the technical scope disclosed in this application should be included in the scope of protection of this application. Therefore, the scope of protection of this application should be based on the scope of protection of the claims.

Claims

1. A detection system for detecting physiological parameters, characterized in that: Includes patches and electronics; The patch includes: a substrate, a first electrode interface, an adhesive layer and a first microneedle; The first electrode interface is disposed on the first surface of the substrate; The adhesive layer is provided on the second surface of the substrate, the second surface facing away from the first surface, and the adhesive layer is used to adhere the patch to the skin; The first microneedle is disposed on the second surface of the substrate; wherein a first electrode is disposed on the first microneedle, and the first electrode is coupled to the first electrode interface; The electronic device comprises: an electrochemical sensing circuit and a first external interface; The first external interface is provided on the back of the electronic device, wherein the first external interface is coupled to the electrochemical sensing circuit; wherein, when the back of the electronic device is worn toward the human body, the first external interface is electrically connected to the first electrode interface and transmits electrical signals between the patch and the electronic device; The first electrode interface is magnetic or made of a magnetic material; and the first external interface is magnetic or made of a magnetic material.

2. The detection system according to claim 1, characterized in that The first microneedle is further provided with a second electrode, and the patch further comprises: a second electrode interface, the second electrode interface being provided on the first surface of the substrate; wherein the second electrode is coupled to the second electrode interface; The electronic device also includes a second external interface, which is arranged on the back of the electronic device and is coupled to the electrochemical sensing circuit; wherein, when the back of the electronic device is worn facing the human body, the second external interface is electrically connected to the second electrode interface and transmits electrical signals between the patch and the electronic device.

3. The detection system according to claim 1, characterized in that The patch further comprises: a second microneedle and a second electrode interface; The second microneedle is disposed on the second surface of the substrate; The second electrode interface is provided on the first surface of the substrate; wherein the second microneedle is provided with a second electrode, and the second electrode is coupled to the second electrode interface; The electronic device also includes a second external interface, which is arranged on the back of the electronic device and is coupled to the electrochemical sensing circuit; wherein, when the back of the electronic device is worn facing the human body, the second external interface is electrically connected to the second electrode interface and transmits electrical signals between the patch and the electronic device.

4. The detection system according to claim 2 or 3, characterized in that: The first electrode includes any one of a working electrode and a reference electrode.

5. The detection system according to claim 4, characterized in that: The second electrode includes any one of a working electrode and a reference electrode, wherein the second electrode is different from the first electrode.

6. The detection system according to claim 2 or 3, characterized in that: The second electrode interface is magnetic, or the second electrode interface is made of magnetic material; The second external connection interface is magnetic, or the second external connection interface is made of magnetic material.

7. The detection system according to any one of claims 1 to 3, characterized in that: The patch also includes: A water retaining bar is provided on the first surface of the substrate, wherein the water retaining bar surrounds the first electrode interface.

8. The detection system according to any one of claims 1 to 3, characterized in that: The patch also includes: An application mark is provided on the first surface of the substrate, and is used to indicate an application direction of the patch.

9. The detection system according to claim 2 or 3, characterized in that: The first electrode interface and the second electrode interface are concentrically arranged circular electrode interfaces; The first external connection interface and the second external connection interface are concentrically arranged annular external connection interfaces.

10. The detection system according to any one of claims 1 to 3, characterized in that: The shape of the first electrode includes: columnar, planar or winding.

11. The detection system according to any one of claims 1 to 3, characterized in that: The first electrode includes one or more of the following materials: lamp black carbon, glassy carbon, graphite, silver, silver chloride, platinum, palladium, platinum-iridium alloy, titanium, gold, and iridium.

12. The detection system according to any one of claims 1 to 3, characterized in that: The length of the first microneedle is 1-5 mm, and the diameter of the first microneedle is 7-400 μm.

13. The detection system according to any one of claims 1 to 3, characterized in that: The material of the first microneedle includes stainless steel, platinum or polymer material.

14. The detection system according to any one of claims 1 to 3, characterized in that: The patch further includes: a first magnetic interface, which is provided on the first surface of the substrate; the first magnetic interface is magnetic, or the first magnetic interface is made of magnetic material; The electronic device further comprises: a second magnetic interface provided on the back of the electronic device, the second magnetic interface being magnetic, or being made of magnetic material; When the back of the electronic device is worn toward the human body, the first magnetic interface and the second magnetic interface are attracted to each other.

15. A patch for detecting physiological parameters, characterized in that: include: substrate; a first electrode interface, the first electrode interface being disposed on the first surface of the substrate and configured to transmit electrical signals between the patch and the electronic device after being electrically connected to a first external interface of the electronic device; an adhesive layer, the adhesive layer being disposed on the second surface of the substrate, the second surface facing away from the first surface, and the adhesive layer being used to adhere the patch to the skin; a first microneedle disposed on the second surface of the substrate; Wherein, a first electrode is provided on the first microneedle, and the first electrode is coupled to the first electrode interface; The first electrode interface is magnetic or made of a magnetic material; and the first external interface is magnetic or made of a magnetic material.

16. The patch according to claim 15, characterized in that The first microneedle is further provided with a second electrode, and the patch further comprises: a second electrode interface, the second electrode interface being disposed on the first surface of the substrate; Wherein, the second electrode is coupled to the second electrode interface.

17. The patch according to claim 15, characterized in that The patch also includes: a second microneedle disposed on the second surface of the substrate; a second electrode interface, the second electrode interface being disposed on the first surface of the substrate; Wherein, a second electrode is provided on the second microneedle, and the second electrode is coupled to the second electrode interface.

18. The patch according to claim 16 or 17, characterized in that: The first electrode includes any one of a working electrode and a reference electrode.

19. The patch according to claim 18, characterized in that The second electrode includes any one of a working electrode and a reference electrode, wherein the second electrode is different from the first electrode.

20. The patch according to claim 16 or 17, characterized in that: The second electrode interface is magnetic, or the second electrode interface is made of magnetic material.

21. The patch according to any one of claims 15 to 17, characterized in that: The patch also includes: A water retaining bar is provided on the first surface of the substrate, wherein the water retaining bar surrounds the first electrode interface.

22. The patch according to any one of claims 15 to 17, characterized in that: The patch also includes: An application mark is provided on the first surface of the substrate, and is used to indicate an application direction of the patch.

23. The patch according to claim 16 or 17, characterized in that: The first electrode interface and the second electrode interface are concentrically arranged annular electrode interfaces.

24. The patch according to any one of claims 15 to 17, characterized in that: The shape of the first electrode includes: columnar, planar or winding.

25. The patch according to any one of claims 15 to 17, characterized in that: The first electrode includes one or more of the following materials: lamp black carbon, glassy carbon, graphite, silver, silver chloride, platinum, palladium, platinum-iridium alloy, titanium, gold, and iridium.

26. The patch according to any one of claims 15 to 17, characterized in that: The length of the first microneedle is 1-5 mm, and the diameter of the first microneedle is 7-400 μm.

27. The patch according to any one of claims 15 to 17, characterized in that: The material of the first microneedle includes stainless steel, platinum or polymer material.

28. The patch according to any one of claims 15 to 17, characterized in that: Also includes: The first magnetic interface is provided on the first surface of the base; the first magnetic interface is magnetic, or the first magnetic interface is made of magnetic material.

29. An electronic device for detecting physiological parameters, characterized in that: include: electrochemical sensing circuit; a first external interface, the first external interface being disposed on the back of the electronic device, wherein the first external interface is coupled to the electrochemical sensing circuit; wherein, when the back of the electronic device is worn toward the human body, the first external interface is electrically connected to the first electrode interface on the patch and transmits electrical signals between the patch and the electronic device; and the patch is adhered to the skin; The first electrode interface is magnetic or made of a magnetic material; and the first external interface is magnetic or made of a magnetic material.

30. The electronic device according to claim 29, wherein The electronic device also includes a second external interface, which is arranged on the back of the electronic device, wherein the second external interface is coupled to the electrochemical sensing circuit; wherein, when the back of the electronic device is worn facing the human body, the second external interface is electrically connected to the second electrode interface of the patch and transmits electrical signals between the patch and the electronic device.

31. The electronic device according to claim 29 or 30, characterized in that: It also includes: a second magnetic interface arranged on the back of the electronic device, the second magnetic interface is magnetic, or the second magnetic interface is made of magnetic material.

32. The electronic device according to claim 30, wherein: The first external connection interface and the second external connection interface are concentrically arranged annular external connection interfaces.

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